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Sepsis in young infants with congenital heart disease.

Publication ,  Journal Article
Ascher, SB; Smith, PB; Clark, RH; Cohen-Wolkowiez, M; Li, JS; Watt, K; Jacqz-Aigrain, E; Kaguelidou, F; Manzoni, P; Benjamin, DK
Published in: Early Hum Dev
May 2012

BACKGROUND: We sought to describe the incidence, pathogen distribution, and mortality associated with blood culture-proven sepsis in young infants with congenital heart disease (CHD) admitted to a neonatal intensive care unit (NICU). METHODS: Cohort study of all blood cultures obtained from infants with CHD between 4 and 120 days of age cared for in 250 NICUs managed by the Pediatrix Medical Group in the United States between 1996 and 2007. RESULTS: Of 11,638 infants with CHD, 656 (6%) had 821 episodes of sepsis: a cumulative incidence of 71/1000 admissions. Gram-positive organisms were the most common cause (64%), and coagulase-negative Staphylococcus and Staphylococcus aureus were the most frequently isolated species. On multivariable regression, infants with sepsis were more likely to die compared to infants with sterile blood cultures (odds ratio [OR] = 1.53 [95% confidence interval: 1.09, 2.13]). Infants with Gram-negative bacteraemia and candidaemia were more likely to die than infants with sterile blood cultures (OR = 2.01 [1.20, 3.37], and OR = 3.18 [1.60, 6.34], respectively). CONCLUSION: Infants with CHD have a high incidence of culture-proven sepsis, especially with staphylococcal organisms. Gram-negative bacteraemia and candidaemia are strongly associated with increased mortality in this group of young infants.

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Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

May 2012

Volume

88 Suppl 2

Issue

Suppl 2

Start / End Page

S92 / S97

Location

Ireland

Related Subject Headings

  • Staphylococcus
  • Staphylococcal Infections
  • Sepsis
  • Pediatrics
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Newborn
  • Infant
  • Humans
  • Heart Defects, Congenital
 

Citation

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Ascher, S. B., Smith, P. B., Clark, R. H., Cohen-Wolkowiez, M., Li, J. S., Watt, K., … Benjamin, D. K. (2012). Sepsis in young infants with congenital heart disease. Early Hum Dev, 88 Suppl 2(Suppl 2), S92–S97. https://doi.org/10.1016/S0378-3782(12)70025-7
Ascher, S. B., P. B. Smith, R. H. Clark, M. Cohen-Wolkowiez, J. S. Li, K. Watt, E. Jacqz-Aigrain, F. Kaguelidou, P. Manzoni, and D. K. Benjamin. “Sepsis in young infants with congenital heart disease.Early Hum Dev 88 Suppl 2, no. Suppl 2 (May 2012): S92–97. https://doi.org/10.1016/S0378-3782(12)70025-7.
Ascher SB, Smith PB, Clark RH, Cohen-Wolkowiez M, Li JS, Watt K, et al. Sepsis in young infants with congenital heart disease. Early Hum Dev. 2012 May;88 Suppl 2(Suppl 2):S92–7.
Ascher, S. B., et al. “Sepsis in young infants with congenital heart disease.Early Hum Dev, vol. 88 Suppl 2, no. Suppl 2, May 2012, pp. S92–97. Pubmed, doi:10.1016/S0378-3782(12)70025-7.
Ascher SB, Smith PB, Clark RH, Cohen-Wolkowiez M, Li JS, Watt K, Jacqz-Aigrain E, Kaguelidou F, Manzoni P, Benjamin DK. Sepsis in young infants with congenital heart disease. Early Hum Dev. 2012 May;88 Suppl 2(Suppl 2):S92–S97.
Journal cover image

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

May 2012

Volume

88 Suppl 2

Issue

Suppl 2

Start / End Page

S92 / S97

Location

Ireland

Related Subject Headings

  • Staphylococcus
  • Staphylococcal Infections
  • Sepsis
  • Pediatrics
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Newborn
  • Infant
  • Humans
  • Heart Defects, Congenital