Skip to main content

GATA2 is associated with familial early-onset coronary artery disease.

Publication ,  Journal Article
Connelly, JJ; Wang, T; Cox, JE; Haynes, C; Wang, L; Shah, SH; Crosslin, DR; Hale, AB; Nelson, S; Crossman, DC; Granger, CB; Haines, JL ...
Published in: PLoS genetics
August 25, 2006

The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the aortic vasculature, namely aortic endothelial cells and smooth muscle cells. We have shown that GATA2 expression is predictive of location within the thoracic aorta; location is suggested to be a surrogate for disease susceptibility. The GATA2 gene maps beneath the Chromosome 3q linkage peak from our family-based sample set (GENECARD) study of early-onset coronary artery disease. Given these observations, we investigated the relationship of several known and novel polymorphisms within GATA2 to coronary artery disease. We identified five single nucleotide polymorphisms that were significantly associated with early-onset coronary artery disease in GENECARD. These results were validated by identifying significant association of two of these single nucleotide polymorphisms in an independent case-control sample set that was phenotypically similar to the GENECARD families. These observations identify GATA2 as a novel susceptibility gene for coronary artery disease and suggest that the study of this transcription factor and its downstream targets may uncover a regulatory network important for coronary artery disease inheritance.

Duke Scholars

Published In

PLoS genetics

DOI

EISSN

1553-7404

Publication Date

August 25, 2006

Volume

2

Issue

8

Related Subject Headings

  • Developmental Biology
  • 3105 Genetics
  • 0604 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Connelly, J. J., Wang, T., Cox, J. E., Haynes, C., Wang, L., Shah, S. H., … Gregory, S. G. (2006). GATA2 is associated with familial early-onset coronary artery disease. PLoS Genetics, 2(8). https://doi.org/10.1371/journal.pgen.0020139
Connelly, J. J., T. Wang, J. E. Cox, C. Haynes, L. Wang, S. H. Shah, D. R. Crosslin, et al. “GATA2 is associated with familial early-onset coronary artery disease.PLoS Genetics 2, no. 8 (August 25, 2006). https://doi.org/10.1371/journal.pgen.0020139.
Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, et al. GATA2 is associated with familial early-onset coronary artery disease. PLoS genetics. 2006 Aug 25;2(8).
Connelly, J. J., et al. “GATA2 is associated with familial early-onset coronary artery disease.PLoS Genetics, vol. 2, no. 8, Aug. 2006. Scopus, doi:10.1371/journal.pgen.0020139.
Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, Crosslin DR, Hale AB, Nelson S, Crossman DC, Granger CB, Haines JL, Jones CJH, Vance JM, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER, Gregory SG. GATA2 is associated with familial early-onset coronary artery disease. PLoS genetics. 2006 Aug 25;2(8).

Published In

PLoS genetics

DOI

EISSN

1553-7404

Publication Date

August 25, 2006

Volume

2

Issue

8

Related Subject Headings

  • Developmental Biology
  • 3105 Genetics
  • 0604 Genetics