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Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography.

Publication ,  Journal Article
Allingham, MJ; Cabrera, MT; O'Connell, RV; Maldonado, RS; Tran-Viet, D; Toth, CA; Freedman, SF; El-Dairi, MA
Published in: J AAPOS
October 2013

PURPOSE: To characterize optic nerve head (ONH) morphology and parameters, including vertical disk diameter, vertical cup diameter, and vertical cup/disk ratio in healthy, full-term newborns using a handheld spectral domain optical coherence tomography (SD-OCT) device. METHODS: In this prospective observational case series, healthy white, black, and Hispanic full-term newborns delivered at the Duke Birthing Center between August 2010 and May 2011 underwent dilated fundus examination and SD-OCT imaging of the optic nerve in each eye. OCT parameters were calculated and compared for each group of infants. RESULTS: A total of 58 consecutive newborns of white (n = 22), black (n = 15) and Hispanic (n = 21) ethnicity were included. Mean vertical disk diameter in white, black, and Hispanic newborns was 1.29 ± 0.15 mm (standard deviation), 1.38 ± 0.14 mm, and 1.38 ± 0.14 mm, respectively (white versus Hispanic, P = 0.02; white versus black, P = 0.07). Mean vertical cup diameter in white, black, and Hispanic newborns was 0.44 ± 0.15 mm, 0.56 ± 0.23 mm, and 0.46 ± 0.30 mm, respectively (white versus black, P = 0.03). Mean vertical cup/disk ratio was 0.34 ± 0.10 for white, 0.40 ± 0.17 for black, and 0.33 ± 0.20 for Hispanic newborns (P = 0.07 for white versus black). CONCLUSIONS: Handheld SD-OCT is an effective means of imaging the ONH in newborns. Racial differences in cup/disk ratio are present at birth. These data may serve as the beginning of a normative dataset for characterizing development of the ONH as well as for comparison to the neonatal ONH in disease states.

Duke Scholars

Published In

J AAPOS

DOI

EISSN

1528-3933

Publication Date

October 2013

Volume

17

Issue

5

Start / End Page

501 / 506

Location

United States

Related Subject Headings

  • White People
  • Tomography, Optical Coherence
  • Prospective Studies
  • Point-of-Care Systems
  • Optic Disk
  • Ophthalmoscopy
  • Ophthalmology & Optometry
  • Male
  • Infant, Newborn
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Allingham, M. J., Cabrera, M. T., O’Connell, R. V., Maldonado, R. S., Tran-Viet, D., Toth, C. A., … El-Dairi, M. A. (2013). Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography. J AAPOS, 17(5), 501–506. https://doi.org/10.1016/j.jaapos.2013.06.014
Allingham, Michael J., Michelle T. Cabrera, Rachelle V. O’Connell, Ramiro S. Maldonado, Du Tran-Viet, Cynthia A. Toth, Sharon F. Freedman, and Mays A. El-Dairi. “Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography.J AAPOS 17, no. 5 (October 2013): 501–6. https://doi.org/10.1016/j.jaapos.2013.06.014.
Allingham MJ, Cabrera MT, O’Connell RV, Maldonado RS, Tran-Viet D, Toth CA, et al. Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography. J AAPOS. 2013 Oct;17(5):501–6.
Allingham, Michael J., et al. “Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography.J AAPOS, vol. 17, no. 5, Oct. 2013, pp. 501–06. Pubmed, doi:10.1016/j.jaapos.2013.06.014.
Allingham MJ, Cabrera MT, O’Connell RV, Maldonado RS, Tran-Viet D, Toth CA, Freedman SF, El-Dairi MA. Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography. J AAPOS. 2013 Oct;17(5):501–506.
Journal cover image

Published In

J AAPOS

DOI

EISSN

1528-3933

Publication Date

October 2013

Volume

17

Issue

5

Start / End Page

501 / 506

Location

United States

Related Subject Headings

  • White People
  • Tomography, Optical Coherence
  • Prospective Studies
  • Point-of-Care Systems
  • Optic Disk
  • Ophthalmoscopy
  • Ophthalmology & Optometry
  • Male
  • Infant, Newborn
  • Humans