Scholars@Duke
Clerio Francisco De Azevedo Filho

Clerio Francisco De Azevedo Filho

Instructor in the Department of Medicine
Medicine, Cardiology
clerio.azevedo@duke.edu
DUMC 3934, Durham, NC 27710
10 Medicine Circle, Duke Medical Pavilion - Room 1E63, Durham, NC 27710

Selected Publications

Native T1 Mapping for the Diagnosis of Myocardial Fibrosis in Patients With Chronic Myocardial Infarction.

Journal Article JACC Cardiovasc Imaging · December 2022 BACKGROUND: Myocardial fibrosis is a fundamental process in cardiac injury. Cardiac magnetic resonance native T1 mapping has been proposed for diagnosing myocardial fibrosis without the need for gadolinium contrast. However, recent studies suggest that T1 ... Full text Link to item Cite

Assessment of Papillary Muscle Infarction with Dark-Blood Delayed Enhancement Cardiac MRI in Canines and Humans.

Journal Article Radiology · November 2022 Background The relationship between papillary muscle infarction (papMI) and the culprit coronary lesion has not been fully investigated. Delayed enhancement cardiac MRI may detect papMI, yet its accuracy is unknown. Flow-independent dark-blood delayed enha ... Full text Link to item Cite

Assessment of myocardial lipomatous metaplasia using an optimized out-of-phase cine steady-state free-precession sequence: Validation and clinical implementation.

Journal Article NMR Biomed · October 2022 Myocardial lipomatous metaplasia, which can serve as substrate for ventricular arrhythmias, is usually composed of regions in which there is an admixture of fat and nonfat tissue. Although dedicated sequences for the detection of fat are available, it woul ... Full text Link to item Cite

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination.

Journal Article JAMA Cardiol · October 1, 2021 IMPORTANCE: Vaccine-associated myocarditis is an unusual entity that has been described for the smallpox vaccine, but only anecdotal case reports have been described for other vaccines. Whether COVID-19 vaccination may be linked to the occurrence of myocar ... Full text Link to item Cite

ECG-gated MR angiography provides better reproducibility for standard aortic measurements.

Journal Article Eur Radiol · July 2021 OBJECTIVE: Cardiac motion and aortic pulsatility can affect the image quality of 3D contrast-enhanced MR angiography (CE-MRA). The addition of ECG gating improves image quality; however, no studies have directly linked image quality improvements to clinica ... Full text Link to item Cite

Lower Prevalence and Severity of Coronary Atherosclerosis in Chronic Chagas' Disease by Coronary Computed Tomography Angiography.

Journal Article Arq Bras Cardiol · December 2020 BACKGROUND: In Chagas' disease endemic regions, there has been for many years a recurrent empirical observation that coronary artery disease (CAD) is uncommon in patients with Chagas' disease. Previous pathological and invasive coronary angiography studies ... Full text Link to item Cite

Comparison of magnetization transfer-preparation and T2-preparation for dark-blood delayed-enhancement imaging.

Journal Article NMR Biomed · November 2020 Recently developed dark-blood techniques such as Flow-Independent Dark-blood DeLayed Enhancement (FIDDLE) allow simultaneous visualization of tissue contrast-enhancement and blood-pool suppression. Critical to FIDDLE is the magnetization preparation, which ... Full text Link to item Cite

Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease.

Journal Article Am J Trop Med Hyg · August 2020 Chronic Chagas disease can progress to myocardial involvement with intense fibrosis, which may predispose patients to sudden cardiac death through ventricular arrhythmia. The associations of myocardial fibrosis detected by cardiac magnetic resonance (CMR) ... Full text Link to item Cite

Therapy with Cardiomyocytes Derived from Pluripotent Cells in Chronic Chagasic Cardiomyopathy.

Journal Article Cells · July 7, 2020 Chagas disease discovered more than a century ago remains an incurable disease. The objective of this work was to investigate the therapeutic potential of cardiomyocytes derived from mouse embryonic stem cells (CM-mESC) in a model of chronic Chagasic cardi ... Full text Link to item Cite

Longitudinal Shortening of the Left Ventricle by Cine-CMR for Assessment of Diastolic Function in Patients with Aortic Valve Disease.

Journal Article Arq Bras Cardiol · February 2020 BACKGROUND: Diastolic dysfunction, commonly evaluated by echocardiography, is an important early finding in many cardiomyopathies. Cardiac magnetic resonance (CMR) often requires specialized sequences that extends the test time. Recently, feature-tracking ... Full text Link to item Cite

Comprehensive Assessment of Endomyocardial Fibrosis with Cardiac MRI: Morphology, Function, and Tissue Characterization.

Journal Article Radiographics · 2020 Endomyocardial fibrosis (EMF) affects approximately 12 million persons worldwide and is an important cause of restrictive cardiomyopathy in the developing world, with the highest prevalence reported in sub-Saharan Africa, South Asia, and South America. EMF ... Full text Link to item Cite

The Role of Cardiac MR Imaging in the Assessment of Patients with Cardiac Amyloidosis.

Journal Article Magn Reson Imaging Clin N Am · August 2019 Despite recent advancements in newer biomarkers development and improved imaging techniques, the diagnosis of cardiac amyloidosis (CA) remains a frequent clinical challenge. In this setting, cardiac MR (CMR) imaging has emerged as a powerful tool to assess ... Full text Link to item Cite

Cardiovascular MR Imaging: Current Status and Future Directions

Journal Article Magnetic Resonance Imaging Clinics of North America · August 1, 2019 Full text Cite

Machine learning derived segmentation of phase velocity encoded cardiovascular magnetic resonance for fully automated aortic flow quantification.

Journal Article J Cardiovasc Magn Reson · January 7, 2019 BACKGROUND: Phase contrast (PC) cardiovascular magnetic resonance (CMR) is widely employed for flow quantification, but analysis typically requires time consuming manual segmentation which can require human correction. Advances in machine learning have mar ... Full text Link to item Cite

Myocardial Fibrosis Progression in Duchenne and Becker Muscular Dystrophy: A Randomized Clinical Trial.

Journal Article JAMA Cardiol · February 1, 2017 Featured Publication IMPORTANCE: In Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), interventions reducing the progression of myocardial disease could affect survival. OBJECTIVE: To assess the effect of early angiotensin-converting enzyme (ACE) inhibitor ... Full text Open Access Link to item Cite

Analysis of Regional Left Ventricular Strain in Patients with Chagas Disease and Normal Left Ventricular Systolic Function.

Journal Article J Am Soc Echocardiogr · July 2016 Featured Publication BACKGROUND: Chagas heart disease has a high socioeconomic burden, and any strategy to detect early myocardial damage is welcome. Speckle-tracking echocardiography assesses global and segmental left ventricular (LV) systolic function, yielding values of two ... Full text Link to item Cite

Free-breathing myocardial T2* mapping using GRE-EPI and MOCO for myocardial and hepatic iron overload assessment: a multi-centre study.

Journal Article Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · January 27, 2016 Full text Cite

Changes in Medical Management after Coronary CT Angiography.

Journal Article Arq Bras Cardiol · October 2015 INTRODUCTION: Coronary computed tomography angiography (CCTA) allows for non-invasive coronary artery disease (CAD) phenotyping. There are still some uncertainties regarding the impact this knowledge has on the clinical care of patients. OBJECTIVE: To dete ... Full text Open Access Link to item Cite

Assessment of myocardial infarction by cardiac magnetic resonance imaging and long-term mortality.

Journal Article Arq Bras Cardiol · February 2015 BACKGROUND: Cardiac magnetic resonance imaging provides detailed anatomical information on infarction. However, few studies have investigated the association of these data with mortality after acute myocardial infarction. OBJECTIVE: To study the associatio ... Full text Open Access Link to item Cite

Accuracy of multidetector computed tomography for detection of coronary artery stenosis in acute coronary syndrome compared with stable coronary disease: a CORE64 multicenter trial substudy.

Journal Article Int J Cardiol · December 15, 2014 Featured Publication BACKGROUND: Multi-detector computed tomography angiography (MDCTA) is a promising method for risk assessment of patients with acute chest pain. However, its diagnostic performance in higher-risk patients has not been investigated in a large international m ... Full text Link to item Cite

Ex-vivo Assessment of Coronary Artery Atherosclerosis by Magnetic Resonance Imaging: Correlation with Histopathology.

Journal Article Open Cardiovasc Med J · 2014 INTRODUCTION: In recent years, high-resolution magnetic resonance imaging (MRI) has emerged as a very promising technique for studying atherosclerotic disease in humans. AIM: In the present study we sought to determine whether MRI allowed for the morpholog ... Full text Open Access Link to item Cite

Reply: To PMID 22892694.

Journal Article Arq Bras Cardiol · May 2013 Link to item Cite

Reply.

Journal Article Arquivos brasileiros de cardiologia · May 1, 2013 Cite

Transthoracic impedance compared to magnetic resonance imaging in the assessment of cardiac output.

Journal Article Arq Bras Cardiol · December 2012 BACKGROUND: Cardiac magnetic resonance imaging is considered the gold-standard method for the calculation of cardiac volumes. Transthoracic impedance cardiography assesses the cardiac output. No studies validating this measurement, in comparison to that ob ... Full text Open Access Link to item Cite

Free and open-source software application for the evaluation of coronary computed tomography angiography images.

Journal Article Arq Bras Cardiol · October 2012 BACKGROUND: The standardization of images used in Medicine in 1993 was performed using the DICOM (Digital Imaging and Communications in Medicine) standard. Several tests use this standard and it is increasingly necessary to design software applications cap ... Full text Open Access Link to item Cite

Diltiazem as an alternative to beta-blocker in coronary artery computed tomography angiography.

Journal Article Arq Bras Cardiol · August 2012 BACKGROUND: Reducing heart rate (HR) in CT angiography of the coronary arteries (CTACor) is critical to image quality. The effectiveness of calcium channel blockers as alternatives for patients with contraindications to beta-blockers has not been establish ... Full text Open Access Link to item Cite

Coronary artery calcium score and coronary computed tomographic angiography for cardiovascular risk stratification.

Journal Article Arq Bras Cardiol · June 2012 Cardiovascular disease is the leading mortality cause worldwide. The capacity to identify among the asymptomatic individuals the subgroup at greater risk for developing cardiovascular events is fundamental in any strategy aimed at reducing the rate of card ... Full text Open Access Link to item Cite

The myocardial area at risk.

Journal Article Heart · March 2012 Featured Publication Full text Link to item Cite

Prognostic value of CT angiography in patients with inconclusive functional stress tests.

Journal Article JACC Cardiovasc Imaging · July 2011 Featured Publication OBJECTIVES: We attempted to determine the prognostic value of coronary computed tomographic angiography (CTA) in patients with inconclusive functional stress tests. BACKGROUND: Patients with suspected coronary artery disease (CAD) and inconclusive noninvas ... Full text Link to item Cite

Single-Breathhold Four-Dimensional Assessment of Left Ventricular Morphological and Functional Parameters by Magnetic Resonance Imaging Using the VAST Technique.

Journal Article Open Cardiovasc Med J · 2011 INTRODUCTION: The accurate and reproducible assessment of cardiac volumes, function, and mass is of paramount importance in cardiology. In the present study we sought to determine whether the 3D cine-magnetic resonance (MR) technique, using the variable as ... Full text Open Access Link to item Cite

Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease.

Journal Article J Am Coll Cardiol · July 20, 2010 Featured Publication OBJECTIVES: We sought to determine whether the quantitative assessment of myocardial fibrosis (MF), either by histopathology or by contrast-enhanced magnetic resonance imaging (ce-MRI), could help predict long-term survival after aortic valve replacement. ... Full text Link to item Cite

Contrast-enhanced magnetic resonance imaging identifies focal regions of intramyocardial fibrosis in patients with severe aortic valve disease: Correlation with quantitative histopathology.

Journal Article Am Heart J · February 2009 BACKGROUND: Chronic aortic valve disease (AVD) is characterized by progressive accumulation of interstitial myocardial fibrosis (MF). However, assessment of MF accumulation has only been possible through histologic analyses of endomyocardial biopsies. We s ... Full text Link to item Cite

The 3rd Brazilian Guidelines for Chronic Heart Failure

Journal Article Arquivos Brasileiros De Cardiologia · January 1, 2009 Full text Cite

High temporal resolution breathheld 3D FIESTA CINE imaging: validation of ventricular function in patients with chronic myocardial infarction.

Journal Article J Magn Reson Imaging · June 2007 PURPOSE: To develop a gated single-breathhold, high temporal resolution three-dimensional (3D) CINE imaging technique and to evaluate its accuracy in volumetric and functional quantification in patients with chronic myocardial infarction. MATERIALS AND MET ... Full text Link to item Cite

Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction.

Journal Article Circulation · April 17, 2007 Featured Publication BACKGROUND: The extent of the peri-infarct zone by magnetic resonance imaging (MRI) has been related to all-cause mortality in patients with coronary artery disease. This relationship may result from arrhythmogenesis in the infarct border. However, the rel ... Full text Link to item Cite

Cardiac imaging to identify patients at risk for developing heart failure after myocardial infarction.

Journal Article Curr Heart Fail Rep · December 2005 The development of heart failure (HF) after acute myocardial infarction (MI) is recognized as a major complication that leads to a significant increase in morbidity and mortality. Given the availability of effective treatments for improving both quality of ... Full text Link to item Cite

The effect of intra-aortic balloon counterpulsation on left ventricular functional recovery early after acute myocardial infarction: a randomized experimental magnetic resonance imaging study.

Journal Article Eur Heart J · June 2005 Featured Publication AIMS: We sought to determine whether intra-aortic balloon pump (IABP) counterpulsation improves the recovery of left ventricular (LV) systolic function after reperfused acute myocardial infarction (AMI). METHODS AND RESULTS: Fourteen dogs underwent 90-min ... Full text Link to item Cite

Persistent diastolic dysfunction despite complete systolic functional recovery after reperfused acute myocardial infarction demonstrated by tagged magnetic resonance imaging.

Journal Article Eur Heart J · August 2004 Featured Publication AIMS: This study was designed to characterise both the systolic and diastolic mechanical properties of regions with different degrees of myocardial ischaemic injury after reperfused acute myocardial infarction (AMI). METHODS AND RESULTS: Fourteen dogs unde ... Full text Link to item Cite

Quantification of left ventricular infarcted mass on cardiac magnetic resonance imaging: comparison between planimetry and the semiquantitative visual scoring method.

Journal Article Arq Bras Cardiol · August 2004 OBJECTIVE: To compare a new semiquantitative visual scoring method with quantitative digital planimetry for determining left ventricular infarcted mass by use of cardiac delayed contrast-enhanced magnetic resonance imaging. METHOD: Seventy-seven patients w ... Full text Link to item Cite