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Shih-Hsiu Wang

Associate Professor of Pathology
Pathology
Box 3712, Durham, NC 27710
40 Duke Medicine Circle, Box 3712, Durham, NC 27710

Selected Publications


Very-late-onset multiple Acyl-coenzyme a dehydrogenase deficiency with elevated GDF-15 and Aldolase: a case report.

Journal Article Neuromuscul Disord · December 2024 A 72-year-old woman on sertraline and levothyroxine (Levoxyl) presented to clinic with progressive proximal > distal and left > right upper and lower extremity weakness. She had length-dependent paresthesias and sensory deficits. Aldolase was elevated but ... Full text Link to item Cite

Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.

Journal Article JAMA Ophthalmol · November 14, 2024 IMPORTANCE: Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations. OBJECTIVE: To evaluate how establi ... Full text Link to item Cite

Star-shaped TDP-43 inclusions in the oldest-old.

Journal Article J Neuropathol Exp Neurol · November 4, 2024 Full text Link to item Cite

MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study.

Journal Article Lancet Neurol · May 2024 BACKGROUND: Pick's disease is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary tauopathy. Pick's disease is pathologically defined by the presence in the frontal and temporal lobes of Pick bodies, composed o ... Full text Link to item Cite

Intermediate Antiparallel β Structure in Amyloid β Plaques Revealed by Infrared Spectroscopic Imaging.

Journal Article ACS Chem Neurosci · October 18, 2023 Aggregation of amyloid β (Aβ) peptides into extracellular plaques is a hallmark of the molecular pathology of Alzheimer's disease (AD). Amyloid aggregates have been extensively studied in vitro, and it is well-known that mature amyloid fibrils contain an o ... Full text Link to item Cite

LATE-NC staging in routine neuropathologic diagnosis: an update.

Journal Article Acta Neuropathol · February 2023 An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested neuropathologic staging system and nomenclature have proven useful for a ... Full text Link to item Cite

Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF.

Journal Article Front Mol Neurosci · 2023 Alzheimer's disease (AD) is characterized by a long preclinical phase. Although late-stage AD/dementia may be robustly differentiated from cognitively normal individuals by means of a clinical evaluation, PET imaging, and established biofluid biomarkers, d ... Full text Link to item Cite

GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans.

Journal Article Sci Adv · December 21, 2022 Aging causes functional decline and degeneration of neurons and is a major risk factor of neurodegenerative diseases. To investigate the molecular mechanisms underlying neuronal aging, we developed a new pipeline for neuronal proteomic profiling in young a ... Full text Link to item Cite

Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation.

Journal Article ACS Chem Neurosci · December 7, 2022 Tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Such misfolded tau aggregates are ... Full text Link to item Cite

Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease.

Journal Article Acta Neuropathol Commun · August 8, 2022 Corpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are age-related, carbohydrate-rich structures that serve as waste repositories for aggregated proteins, damaged cellular organelles, and other cellular debris. The structu ... Full text Link to item Cite

Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old.

Journal Article Acta Neuropathol · July 2022 Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is most often seen in the oldest-old (≥ 90 years of age) but can also be present in the younger-old (< 90 years of age). In this study, we compared the neuropathologica ... Full text Open Access Link to item Cite

Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.

Journal Article Acta Neuropathol · July 2022 Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with substantial cognitive impairment in aging populations. However, the prevalence of LATE-NC a ... Full text Link to item Cite

Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation.

Journal Article Acta Neuropathol Commun · March 3, 2022 Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 and TSC2 genes and autosomal dominantly inherited. These mutations cause hyperactivation of the mammalian Target of Rapamycin (mTOR) pathway, leading to the d ... Full text Link to item Cite

A Case of Fragile X-Associated Tremor/Ataxia Syndrome in Association With an Unclassified Tauopathy

Conference JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY · 2022 Cite