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A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy.

Publication ,  Journal Article
Eichenberger, EM; Saullo, J; Brander, D; Wang, S-H; Perfect, JR; Messina, JA
Published in: Med Mycol Case Rep
March 2020

Ibrutinib has revolutionized the treatment of chronic lymphoid malignancies. Despite its success, ibrutinib has been linked with several reports of invasive fungal infections. We present a case of CNS aspergillosis in a CLL patient on first line ibrutinib therapy. We summarize existing case reports and case series of invasive aspergillosis in patients on ibrutinib, the pathogenesis of invasive aspergillosis, and discuss the clinical controversies regarding anti-fungal prophylaxis in this population.

Duke Scholars

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Published In

Med Mycol Case Rep

DOI

ISSN

2211-7539

Publication Date

March 2020

Volume

27

Start / End Page

17 / 21

Location

Netherlands

Related Subject Headings

  • 3207 Medical microbiology
 

Citation

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Eichenberger, E. M., Saullo, J., Brander, D., Wang, S.-H., Perfect, J. R., & Messina, J. A. (2020). A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy. Med Mycol Case Rep, 27, 17–21. https://doi.org/10.1016/j.mmcr.2019.12.007
Eichenberger, Emily M., Jennifer Saullo, Danielle Brander, Shih-Hsiu Wang, John R. Perfect, and Julia A. Messina. “A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy.Med Mycol Case Rep 27 (March 2020): 17–21. https://doi.org/10.1016/j.mmcr.2019.12.007.
Eichenberger EM, Saullo J, Brander D, Wang S-H, Perfect JR, Messina JA. A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy. Med Mycol Case Rep. 2020 Mar;27:17–21.
Eichenberger, Emily M., et al. “A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy.Med Mycol Case Rep, vol. 27, Mar. 2020, pp. 17–21. Pubmed, doi:10.1016/j.mmcr.2019.12.007.
Eichenberger EM, Saullo J, Brander D, Wang S-H, Perfect JR, Messina JA. A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy. Med Mycol Case Rep. 2020 Mar;27:17–21.
Journal cover image

Published In

Med Mycol Case Rep

DOI

ISSN

2211-7539

Publication Date

March 2020

Volume

27

Start / End Page

17 / 21

Location

Netherlands

Related Subject Headings

  • 3207 Medical microbiology