Scholars@Duke
Steven Jeffrey Eliades

Steven Jeffrey Eliades

Associate Professor of Head and Neck Surgery & Communication Sciences
Otology, Neurotology & Skull Base Surgery
steven.eliades@duke.edu
DUMC Box 3805, Durham, NC 27710
Bryan 427F, Durham, NC 27710

Selected Publications

Toward a Diagnostic Imaging Algorithm for Undifferentiated Pulsatile Tinnitus.

Journal Article Otol Neurotol · September 1, 2024 OBJECTIVE: Decisions around the diagnostic evaluation for pulsatile tinnitus (PT) remain challenging. We describe the usage patterns and diagnostic accuracy of imaging modalities and propose an evidence-based diagnostic approach for undifferentiated PT. ST ... Full text Link to item Cite

Reassessing the Utility of Surgical Intervention for Skull Base Osteomyelitis: A 16-Year Experience.

Journal Article Otolaryngol Head Neck Surg · July 2024 OBJECTIVE: The role of surgery in lateral skull base osteomyelitis (SBO) is controversial. Surgical intervention is often requested by consulting services in the interest of additional culture data to inform medical management. However, whether surgery alt ... Full text Link to item Cite

Multiple processes of vocal sensory-motor interaction in primate auditory cortex.

Journal Article Nat Commun · April 10, 2024 Sensory-motor interactions in the auditory system play an important role in vocal self-monitoring and control. These result from top-down corollary discharges, relaying predictions about vocal timing and acoustics. Recent evidence suggests such signals may ... Full text Link to item Cite

Meningitis Risk and Role of Prophylactic Antibiotics in Spontaneous Lateral Skull Base CSF Leaks.

Journal Article Ann Otol Rhinol Laryngol · December 2023 OBJECTIVE: To review the literature and our institutional experience regarding the risk of meningitis in patients with spontaneous lateral skull base cerebrospinal fluid (sCSF) leaks awaiting surgical repair, and the roles of antibiotic prophylaxis and pne ... Full text Link to item Cite

Meniere's disease and vestibular migraine

Chapter · October 25, 2023 Meniere's Disease and Vestibular Migraine are both vestibular disorders that have the potential to cause episodic vertigo of variable duration. Both diagnoses are predominantly based on clinical assessment, with no known definitive tests to confirm or diff ... Cite

Impact of Anticholinergic Medications on Speech Perception Performance after Cochlear Implantation.

Journal Article Otol Neurotol · July 1, 2023 OBJECTIVE: To identify and characterize the impact of anticholinergic medications, which have known adverse effects on cognition in older adults, on speech perception after cochlear implantation. STUDY DESIGN: Retrospective cohort. SETTING: Tertiary referr ... Full text Link to item Cite

Effects of Cortical Stimulation on Feedback-Dependent Vocal Control in Non-Human Primates.

Journal Article Laryngoscope · April 2023 OBJECTIVES: Hearing plays an important role in our ability to control voice, and perturbations in auditory feedback result in compensatory changes in vocal production. The auditory cortex (AC) has been proposed as an important mediator of this behavior, bu ... Full text Link to item Cite

Signal processing and stimulation potential within the ascending auditory pathway: a review.

Other Front Neurosci · 2023 The human auditory system encodes sound with a high degree of temporal and spectral resolution. When hearing fails, existing neuroprosthetics such as cochlear implants may partially restore hearing through stimulation of auditory neurons at the level of th ... Full text Link to item Cite

Audiometric and Surgical Outcomes of a Novel Bone-Conduction Hearing Aid.

Journal Article Otol Neurotol · October 1, 2022 OBJECTIVE: To report the audiometric and surgical outcomes of a series of patients having undergone implantation of a novel transcutaneous bone conduction implant (t-BCI). STUDY DESIGN: Retrospective case series. SETTING: Single academic tertiary referral ... Full text Link to item Cite

Comparison of Outcomes of Surgical Repair of Spontaneous Temporal Bone CSF Leaks and Encephaloceles Using Bone Cement and Autologous Material.

Journal Article Otol Neurotol · April 1, 2022 OBJECTIVE: To compare outcomes transmastoid repair of spontaneous middle fossa cerebrospinal fluid (CSF) leak using only bone cement (BC) versus only autologous material (AM) or combined materials (CM) with both bone cement and autologous material. STUDY D ... Full text Link to item Cite

Pure tone audiometry as assessed by a commercially-available mobile phone application compared to formal audiometry.

Journal Article Am J Otolaryngol · 2022 PURPOSE: Comparison of audiometric measurements of commercially available smartphone audiogram application thresholds as compared to gold standard audiometric evaluation. MATERIALS AND METHODS: A single-institution, original contribution. Ninety consecutiv ... Full text Link to item Cite

Auditory Feedback Control of Vocal Pitch in Spasmodic Dysphonia.

Journal Article Laryngoscope · September 2021 OBJECTIVES/HYPOTHESIS: Hearing plays an important role in the maintenance of vocal control in normal individuals. In patients with spasmodic dysphonia (SD), however, the ability to maintain sustained control of phonation is impaired. The origins of SD are ... Full text Link to item Cite

Bitter Taste Receptors and Chronic Otitis Media.

Journal Article Otolaryngol Head Neck Surg · August 2021 OBJECTIVE: To evaluate the presence of bitter taste receptors (T2Rs) in the middle ear and to examine their relationship with chronic ear infections. STUDY DESIGN: Cross-sectional study. SETTING: Tertiary care hospital. METHODS: This study enrolled 84 pati ... Full text Link to item Cite

Predictors of Postoperative Electrode Deactivation Among Adult Cochlear Implantees.

Journal Article Otol Neurotol · July 1, 2021 OBJECTIVE: To characterize postoperative electrode functionality after adult cochlear implantation; to identify rationale and risk factors for electrode deactivation. STUDY DESIGN: Retrospective Chart Review. SETTING: Academic Cochlear Implant Center. SUBJ ... Full text Link to item Cite

Age-related Patterns of Vestibular Dysfunction in Dizziness and Imbalance: A Review of Vestibular Testing Results Among 1,116 Patients.

Journal Article Otol Neurotol · July 1, 2021 OBJECTIVE: To characterize differences in vestibular testing results among patients presenting with balance-related complaints; to stratify patterns of testing abnormalities by age. STUDY DESIGN: Retrospective chart review. SETTING: Academic Balance Center ... Full text Link to item Cite

Current practices in nutrition management and disease incidence of common marmosets (Callithrix jacchus).

Journal Article J Med Primatol · June 2021 BACKGROUND: A survey was developed to characterize disease incidence, common pathology lesions, environmental characteristics, and nutrition programs within captive research marmoset colonies. METHODS: Seventeen research facilities completed the electronic ... Full text Link to item Cite

Failure and Revision Surgery After Cochlear Implantation in the Adult Population: A 10-year Single-institution Retrospective and Systematic Review of the Literature.

Journal Article Otol Neurotol · March 1, 2021 OBJECTIVE: To characterize failure rate and etiology after cochlear implantation; to identify predictors and describe outcomes after implant failure. STUDY DESIGN: Retrospective chart review and systematic review of the literature using PubMed and Embase. ... Full text Link to item Cite

Streamlining the Cochlear Implant Evaluation: Utility of Community Audiometry in Cochlear Implant Candidacy Assessment.

Journal Article Otol Neurotol · March 1, 2021 OBJECTIVE: To identify redundancy in the cochlear implant candidacy evaluation and assess its financial impact. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary care academic cochlear implant center. PATIENTS: One hundred thirty-five patients re ... Full text Link to item Cite

A Rare Case of Temporal Bone Pneumocephalus Tracking through the Internal Auditory Canal.

Journal Article ORL J Otorhinolaryngol Relat Spec · 2021 A 39-year-old male with chronic hydrocephalus requiring biventricular shunts presented with progressive pneumocephalus over several years. He showed no improvement following ventriculoperitoneal (VP) shunt revision and anterior skull base repair for a sphe ... Full text Link to item Cite

Real-time feedback control of voice in cochlear implant recipients.

Journal Article Laryngoscope Investig Otolaryngol · December 2020 OBJECTIVES: To evaluate feedback-dependent vocal control in cochlear implant patients using pitch-shifted auditory feedback. METHODS: Twenty-three CI recipients with at least 6 months of implant experience were enrolled. Vocal recordings were performed whi ... Full text Link to item Cite

Lateral Wall Electrodes Increase the Rate of Postactivation Nonauditory Percepts.

Journal Article Otol Neurotol · June 2020 OBJECTIVE: To evaluate factors influencing the development of nonauditory percepts and facial nerve stimulation after cochlear implant (CI) activation. STUDY: Retrospective cohort study. SETTING: Tertiary referral center. PATIENTS: Over the course of 5 yea ... Full text Link to item Cite

Dissociation of Unit Activity and Gamma Oscillations during Vocalization in Primate Auditory Cortex.

Journal Article J Neurosci · May 20, 2020 Vocal production is a sensory-motor process in which auditory self-monitoring is used to ensure accurate communication. During vocal production, the auditory cortex of both humans and animals is suppressed, a phenomenon that plays an important role in self ... Full text Link to item Cite

Corollary Discharge Mechanisms During Vocal Production in Marmoset Monkeys.

Journal Article Biol Psychiatry Cogn Neurosci Neuroimaging · September 2019 Interactions between motor systems and sensory processing are ubiquitous throughout the animal kingdom and play an important role in many sensorimotor behaviors, including both human speech and animal vocalization. During vocal production, the auditory sys ... Full text Link to item Cite

Sudden sensorineural hearing loss as a presenting symptom in superior semicircular canal dehiscence

Journal Article Otolaryngology Case Reports · September 1, 2019 Purpose: To provide new insights into a potential mechanism of sudden sensorineural hearing loss (SSNHL) in superior semicircular canal dehiscence (SCD). Materials and methods: This study is a retrospective case series of three adult subjects who presented ... Full text Cite

Control of speech and voice in cochlear implant patients.

Journal Article Laryngoscope · September 2019 OBJECTIVE: Hearing plays an important role in the learning and production of speech, but the benefits of cochlear implantation for such vocal control are unclear. Here, we present a perspective and review of recent work on the control of speech and voice f ... Full text Link to item Cite

Recent Trends in Vestibular Schwannoma Management: An 11-Year Analysis of the National Cancer Database.

Journal Article Otolaryngol Head Neck Surg · July 2019 OBJECTIVE: A better understanding of the natural history of vestibular schwannoma (VS) has resulted in a change in treatment paradigms. It has also been proposed that increased use of high-resolution magnetic resonance imaging has allowed for an increased ... Full text Link to item Cite

Vestibulotoxicity in a patient without renal failure after inhaled tobramycin.

Journal Article Am J Otolaryngol · 2019 Aminoglycoside antibiotics have a long history of use in the control of gram-negative bacterial infections, but their systemic use has been complicated by known ototoxicity and nephrotoxicity. Because of the utility of these medications in patients with fr ... Full text Link to item Cite

Intratympanic Therapies in Ménière Disease: Evaluation of Outcomes and Early Vertigo Control.

Journal Article Laryngoscope · January 2019 OBJECTIVE: To evaluate outcomes of intratympanic (IT) dexamethasone and gentamicin in Ménière Disease (MD). METHODS: Charts of adult patients with unilateral definite MD receiving IT gentamicin or dexamethasone from 2005 to 2017 were retrospectively review ... Full text Link to item Cite

Auditory cortical activity drives feedback-dependent vocal control in marmosets.

Journal Article Nat Commun · June 29, 2018 Vocal communication is a sensory-motor process requiring auditory self-monitoring to correct errors and to ensure accurate vocal production. When presented with altered speech feedback, humans rapidly change their speech to compensate. Although previous ev ... Full text Link to item Cite

AzBio Speech Understanding Performance in Quiet and Noise in High Performing Cochlear Implant Users.

Journal Article Otol Neurotol · June 2018 OBJECTIVE: To evaluate high-performing cochlear implant patients' performance on AzBio sentence testing. METHODS: Retrospective review of prospectively collected database at a tertiary care hospital. Unilateral cochlear implant patients with AzBio testing ... Full text Link to item Cite

Marmosets in auditory research

Chapter · January 1, 2018 Marmosets have become an important model system in biomedical research. Because of their rich vocal behaviors, marmosets are also of particular interest to those studying behavioral and neural mechanisms related to hearing and vocal communication. Here we ... Full text Cite

Carcinoma of the Middle Ear: A Review of the National Cancer Database.

Journal Article Otol Neurotol · September 2017 INTRODUCTION: Malignancy of the middle ear is a rare condition with limited data available for clinical guidance. STUDY DESIGN: Retrospective evaluation of a large national database. SETTING: Deidentified national cancer database. PATIENTS: Subjects with d ... Full text Link to item Cite

Contributions of sensory tuning to auditory-vocal interactions in marmoset auditory cortex.

Journal Article Hear Res · May 2017 During speech, humans continuously listen to their own vocal output to ensure accurate communication. Such self-monitoring is thought to require the integration of information about the feedback of vocal acoustics with internal motor control signals. The n ... Full text Link to item Cite

Marmoset vocal communication: Behavior and neurobiology.

Journal Article Dev Neurobiol · March 2017 There has been recent increasing interest in the use of marmosets, a New World primate species, as a model in biomedical research. One of the principal advantages of marmosets as a research model is their rich vocal repertoire and communicative vocal behav ... Full text Link to item Cite

Systematic Review of Treatments for Autoimmune Inner Ear Disease.

Journal Article Otol Neurotol · December 2015 OBJECTIVE: To systematically evaluate the evidence for treatment of autoimmune inner ear disease (AIED). DATA SOURCES: Medline/EMBASE, Cochrane Review. STUDY SELECTION: Studies reviewed were English language original articles reporting outcome data for sub ... Full text Link to item Cite

Adaptation of high-gamma responses in human auditory association cortex.

Journal Article J Neurophysiol · November 1, 2014 This study investigates adaptation of high-frequency cortical responses [>60 Hz; high-gamma (HG)] to simple and complex sounds in human nonprimary auditory cortex. We used intracranial electrocorticographic recordings to measure event-related changes in HG ... Full text Link to item Cite

The neurobiology of primate vocal communication.

Journal Article Curr Opin Neurobiol · October 2014 Recent investigations of non-human primate communication revealed vocal behaviors far more complex than previously appreciated. Understanding the neural basis of these communicative behaviors is important as it has the potential to reveal the basic underpi ... Full text Link to item Cite

The role of mastoidectomy in outcomes following tympanic membrane repair: a review.

Journal Article Laryngoscope · July 2013 OBJECTIVES/HYPOTHESIS: The role of mastoidectomy performed with tympanoplasty for tympanic membrane perforations in the absence of cholesteatoma remains controversial. Some authorities suggest that outcomes are improved by the pressure buffering contribute ... Full text Link to item Cite

Comparison of auditory-vocal interactions across multiple types of vocalizations in marmoset auditory cortex.

Journal Article J Neurophysiol · March 2013 Auditory-vocal interaction, the modulation of auditory sensory responses during vocal production, is an important but poorly understood neurophysiological phenomenon in nonhuman primates. This sensory-motor processing has important behavioral implications ... Full text Link to item Cite

Neck dissection through a facelift incision.

Journal Article Laryngoscope · December 2012 OBJECTIVES/HYPOTHESIS: To determine the feasibility and safety of neck dissection through a facelift incision. STUDY DESIGN: Prospective case series. METHODS: Cadavers and live subjects underwent neck dissection using a facelift incision with and without e ... Full text Link to item Cite

Neural correlates of the lombard effect in primate auditory cortex.

Journal Article J Neurosci · August 1, 2012 Speaking is a sensory-motor process that involves constant self-monitoring to ensure accurate vocal production. Self-monitoring of vocal feedback allows rapid adjustment to correct perceived differences between intended and produced vocalizations. One impo ... Full text Link to item Cite

Transoral robotic resection of a lingual thyroglossal duct cyst

Journal Article Journal of Robotic Surgery · January 1, 2012 Thyroglossal duct cysts (TGDCs) are epithelial rests of the thyroid gland left during embryologic descent from the tongue base. Thyroglossal duct cysts confined to the tongue base alone are even more unusual. We present a case of a 45-year-old woman who pr ... Full text Cite

Motor planning for vocal production in common marmosets.

Journal Article Anim Behav · November 2009 The vocal motor plan is one of the most fundamental and poorly understood elements of primate vocal production. Here we tested whether a single vocal motor plan comprises the full length of a vocalization. We hypothesized that if a single motor plan was de ... Full text Link to item Cite

Chronic multi-electrode neural recording in free-roaming monkeys.

Journal Article J Neurosci Methods · July 30, 2008 Many behaviors of interest to neurophysiologists are difficult to study under laboratory conditions because such behaviors are often inhibited when an animal is restrained and socially isolated. Even under the best conditions, such behaviors may be sparse ... Full text Link to item Cite

Neural substrates of vocalization feedback monitoring in primate auditory cortex.

Journal Article Nature · June 19, 2008 Vocal communication involves both speaking and hearing, often taking place concurrently. Vocal production, including human speech and animal vocalization, poses a number of unique challenges for the auditory system. It is important for the auditory system ... Full text Link to item Cite

Calcinosis circumscripta in a common marmoset (Callithrix jacchus jacchus).

Journal Article J Am Assoc Lab Anim Sci · May 2006 A 2.5-y-old, male common marmoset (Callithrix jacchus jacchus) developed a 2-cm, interscapular, subcutaneous mass with variably firm and cystic areas. Radiographs demonstrated a radiodense mass in close proximity to a previously implanted microchip. Fine-n ... Link to item Cite

Dynamics of auditory-vocal interaction in monkey auditory cortex.

Journal Article Cereb Cortex · October 2005 Single neurons in the primate auditory cortex exhibit vocalization-related modulations (excitatory or inhibitory) during self-initiated vocal production. Previous studies have shown that these modulations of cortical activity are variable in individual neu ... Full text Link to item Cite

Wireless multichannel biopotential recording using an integrated FM telemetry circuit.

Journal Article IEEE Trans Neural Syst Rehabil Eng · September 2005 This paper presents a four-channel telemetric microsystem featuring on-chip alternating current amplification, direct current baseline stabilization, clock generation, time-division multiplexing, and wireless frequency-modulation transmission of microvolt- ... Full text Link to item Cite

Sensory-motor interaction in the primate auditory cortex during self-initiated vocalizations.

Journal Article J Neurophysiol · April 2003 Little is known about sensory-motor interaction in the auditory cortex of primates at the level of single neurons and its role in supporting vocal communication. The present study investigated single-unit activities in the auditory cortex of a vocal primat ... Full text Link to item Cite