Scholars@Duke
Akiko Chiba

Akiko Chiba

Associate Professor of Surgery
Surgical Oncology
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Selected Publications

Omission of Axillary Lymph Node Dissection in Patients with Residual Nodal Disease After Neoadjuvant Chemotherapy.

Conference Ann Surg Oncol · September 4, 2024 BACKGROUND: Axillary management after neoadjuvant chemotherapy (NAC) is evolving but axillary lymph node dissection (ALND) remains the standard of care for patients with residual nodal disease. The results of the Alliance A011202 trial evaluating the oncol ... Full text Link to item Cite

Triple-Negative Breast Cancer in Older Patients: Does SLNB Guide Therapy?

Journal Article Ann Surg Oncol · August 28, 2024 BACKGROUND: Older breast cancer patients represent a heterogeneous population. Studies demonstrate that sentinel lymph node biopsy (SLNB) omission may be appropriate in some clinical scenarios, yet patients with triple-negative breast cancer (TNBC) are oft ... Full text Link to item Cite

Rates of Pathologic Complete Response and Overall Survival in Patients with Inflammatory Breast Cancer: A National Cancer Database Study.

Conference Ann Surg Oncol · August 19, 2024 BACKGROUND: Patients with inflammatory breast cancer (IBC) have worse survival compared with stage III non-IBC matched cohorts; however, the prognostic significance of achieving pathologic complete response (pCR) in the setting of IBC is not well described ... Full text Link to item Cite

Assessment of Treatment Sequence in Patients With Stage III Breast Cancer.

Journal Article J Surg Res · August 14, 2024 INTRODUCTION: Stage III breast cancer is defined as locally advanced breast cancer and is treated with curative intent. Historically, overall survival (OS) did not differ based on treatment sequence (neoadjuvant chemotherapy [NAC] followed by surgery versu ... Full text Link to item Cite

The Top Ten Annals of Surgical Oncology Original Articles on Twitter/X: 2020-2023.

Journal Article Ann Surg Oncol · August 13, 2024 Social media has become omnipresent in society, especially given that it enables the rapid and widespread communication of news, events, and information. Social media platforms have become increasingly used by numerous surgical societies to promote meeting ... Full text Link to item Cite

Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia.

Journal Article Ann Surg Oncol · July 21, 2024 BACKGROUND: Proliferative breast atypical lesions, including atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), represent benign entities that confer an elevated risk of ductal carcinoma in situ (DCIS) and invasive breast cancer ... Full text Link to item Cite

Demographics and Clinical Decision Making in Patients with Germline Moderate Penetrance Non-BRCA Mutations in Breast Cancer Related Genes.

Journal Article Ann Surg Oncol · July 8, 2024 BACKGROUND: Management of pathogenic variants in high penetrance genes related to breast cancer (BC), such as BRCA1 and BRCA2, are well established. However, moderate penetrance mutations are understudied. We aim to compare risk reduction decision-making p ... Full text Link to item Cite

Axillary nodal disease burden is not associated with an elevated 21-gene recurrence score in post-menopausal women presenting with a clinically negative axilla.

Journal Article Am J Surg · July 2024 BACKGROUND: The predictive and prognostic value of the recurrence score (RS) has emphasized the importance of tumor biology and has reduced the prognostic implications of limited nodal burden in post-menopausal women with HR+/HER2-invasive breast cancer (I ... Full text Link to item Cite

Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy.

Journal Article J Clin Oncol · May 10, 2024 PURPOSE: Black women have higher rates of death from triple-negative breast cancer (TNBC) than White women. We hypothesized that pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) may vary by race/ethnicity in pa ... Full text Link to item Cite

Anatomy Versus Biology: What Guides Chemotherapy Decisions in Older Patients With Breast Cancer?

Journal Article J Surg Res · April 2024 INTRODUCTION: With the increasing utilization of genomic assays, such as the Oncotype DX recurrence score (RS), the relevance of anatomic staging has been questioned for select older patients with breast cancer. We sought to evaluate differences in chemoth ... Full text Link to item Cite

Correction to: Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro (Cancers, (2018), 10, 5, (144), 10.3390/cancers10050144)

Journal Article Cancers · April 1, 2024 In the original publication [1], there was a mistake in the right side of Figure 1A. The image of a crystal violet plate of MDA-MB-231 cells was inadvertently duplicated from a previous manuscript (reference [27] in original publication [1]). The corrected ... Full text Cite

Rates of high-risk screening prior to a breast cancer diagnosis in patients under age 40.

Journal Article Am J Surg · February 2024 BACKGROUND: NCCN Guidelines recommend screening young women with an increased breast cancer risk (>20 ​% lifetime risk). We sought to evaluate our institutional rates of high-risk screening in young breast cancer patients prior to their diagnoses." METHODS ... Full text Link to item Cite

BRCA1/2 mutation carriers & risk reducing mastectomy: Who undergoes surgery and potential benefits.

Journal Article Am J Surg · January 2024 BACKGROUND: Risk-reducing mastectomy (RRM) is the most effective breast cancer risk-reduction strategy in BRCA1/2 mutation carriers. We examined factors associated with RRM and its relationship with overall survival (OS). METHODS: Patients aged 18-80y at d ... Full text Link to item Cite

Germline Genetic Testing for Patients with Breast Atypia

Conference ANNALS OF SURGICAL ONCOLOGY · 2024 Cite

Pivotal Role of Genetic Counselors in the Uptake of Germline Genetic Testing in Non-Metastatic Breast Cancer and the Impact of Testing on Surgical Decision Making.

Journal Article Am Surg · December 2023 BACKGROUND: Genetic testing is increasingly utilized in breast cancer patients; however, testing rates remain low. We aimed to evaluate the rate of genetic testing at a tertiary academic medical center utilizing a multidisciplinary clinic model including g ... Full text Link to item Cite

Changes in Surgical Management of the Axilla Over 11 Years - Report on More Than 1500 Breast Cancer Patients Treated with Neoadjuvant Chemotherapy on the Prospective I-SPY2 Trial.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Axillary surgery after neoadjuvant chemotherapy (NAC) is becoming less extensive. We evaluated the evolution of axillary surgery after NAC on the multi-institutional I-SPY2 prospective trial. METHODS: We examined annual rates of sentinel lymph ... Full text Link to item Cite

How to Navigate the Treatment Spectrum from Multimodality Therapy to Observation Alone for ductal carcinoma in situ.

Journal Article Surg Oncol Clin N Am · October 2023 DCIS detection has increased dramatically since the introduction of screening mammography. Current guidance concordant care recommends surgical intervention for all patients with DCIS, followed by radiation and/or endocrine therapy for some. Adjuvant thera ... Full text Link to item Cite

Does Preoperative MRI Reduce Positive Margins after Breast-Conserving Surgery?

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Breast-conserving surgery (BCS) is a mainstay for breast cancer management, and obtaining negative margins is critical. Some have advocated for the use of preoperative magnetic resonance imaging (MRI) in reducing positive margins after BCS. We ... Full text Link to item Cite

Omission of Axillary Lymph Node Dissection in Patients with Residual Nodal Disease After Neoadjuvant Chemotherapy.

Conference Ann Surg Oncol · September 4, 2024 BACKGROUND: Axillary management after neoadjuvant chemotherapy (NAC) is evolving but axillary lymph node dissection (ALND) remains the standard of care for patients with residual nodal disease. The results of the Alliance A011202 trial evaluating the oncol ... Full text Link to item Cite

Triple-Negative Breast Cancer in Older Patients: Does SLNB Guide Therapy?

Journal Article Ann Surg Oncol · August 28, 2024 BACKGROUND: Older breast cancer patients represent a heterogeneous population. Studies demonstrate that sentinel lymph node biopsy (SLNB) omission may be appropriate in some clinical scenarios, yet patients with triple-negative breast cancer (TNBC) are oft ... Full text Link to item Cite

Rates of Pathologic Complete Response and Overall Survival in Patients with Inflammatory Breast Cancer: A National Cancer Database Study.

Conference Ann Surg Oncol · August 19, 2024 BACKGROUND: Patients with inflammatory breast cancer (IBC) have worse survival compared with stage III non-IBC matched cohorts; however, the prognostic significance of achieving pathologic complete response (pCR) in the setting of IBC is not well described ... Full text Link to item Cite

Assessment of Treatment Sequence in Patients With Stage III Breast Cancer.

Journal Article J Surg Res · August 14, 2024 INTRODUCTION: Stage III breast cancer is defined as locally advanced breast cancer and is treated with curative intent. Historically, overall survival (OS) did not differ based on treatment sequence (neoadjuvant chemotherapy [NAC] followed by surgery versu ... Full text Link to item Cite

The Top Ten Annals of Surgical Oncology Original Articles on Twitter/X: 2020-2023.

Journal Article Ann Surg Oncol · August 13, 2024 Social media has become omnipresent in society, especially given that it enables the rapid and widespread communication of news, events, and information. Social media platforms have become increasingly used by numerous surgical societies to promote meeting ... Full text Link to item Cite

Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia.

Journal Article Ann Surg Oncol · July 21, 2024 BACKGROUND: Proliferative breast atypical lesions, including atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), represent benign entities that confer an elevated risk of ductal carcinoma in situ (DCIS) and invasive breast cancer ... Full text Link to item Cite

Demographics and Clinical Decision Making in Patients with Germline Moderate Penetrance Non-BRCA Mutations in Breast Cancer Related Genes.

Journal Article Ann Surg Oncol · July 8, 2024 BACKGROUND: Management of pathogenic variants in high penetrance genes related to breast cancer (BC), such as BRCA1 and BRCA2, are well established. However, moderate penetrance mutations are understudied. We aim to compare risk reduction decision-making p ... Full text Link to item Cite

Axillary nodal disease burden is not associated with an elevated 21-gene recurrence score in post-menopausal women presenting with a clinically negative axilla.

Journal Article Am J Surg · July 2024 BACKGROUND: The predictive and prognostic value of the recurrence score (RS) has emphasized the importance of tumor biology and has reduced the prognostic implications of limited nodal burden in post-menopausal women with HR+/HER2-invasive breast cancer (I ... Full text Link to item Cite

Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy.

Journal Article J Clin Oncol · May 10, 2024 PURPOSE: Black women have higher rates of death from triple-negative breast cancer (TNBC) than White women. We hypothesized that pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) may vary by race/ethnicity in pa ... Full text Link to item Cite

Anatomy Versus Biology: What Guides Chemotherapy Decisions in Older Patients With Breast Cancer?

Journal Article J Surg Res · April 2024 INTRODUCTION: With the increasing utilization of genomic assays, such as the Oncotype DX recurrence score (RS), the relevance of anatomic staging has been questioned for select older patients with breast cancer. We sought to evaluate differences in chemoth ... Full text Link to item Cite

Correction to: Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro (Cancers, (2018), 10, 5, (144), 10.3390/cancers10050144)

Journal Article Cancers · April 1, 2024 In the original publication [1], there was a mistake in the right side of Figure 1A. The image of a crystal violet plate of MDA-MB-231 cells was inadvertently duplicated from a previous manuscript (reference [27] in original publication [1]). The corrected ... Full text Cite

Rates of high-risk screening prior to a breast cancer diagnosis in patients under age 40.

Journal Article Am J Surg · February 2024 BACKGROUND: NCCN Guidelines recommend screening young women with an increased breast cancer risk (>20 ​% lifetime risk). We sought to evaluate our institutional rates of high-risk screening in young breast cancer patients prior to their diagnoses." METHODS ... Full text Link to item Cite

BRCA1/2 mutation carriers & risk reducing mastectomy: Who undergoes surgery and potential benefits.

Journal Article Am J Surg · January 2024 BACKGROUND: Risk-reducing mastectomy (RRM) is the most effective breast cancer risk-reduction strategy in BRCA1/2 mutation carriers. We examined factors associated with RRM and its relationship with overall survival (OS). METHODS: Patients aged 18-80y at d ... Full text Link to item Cite

Germline Genetic Testing for Patients with Breast Atypia

Conference ANNALS OF SURGICAL ONCOLOGY · 2024 Cite

Pivotal Role of Genetic Counselors in the Uptake of Germline Genetic Testing in Non-Metastatic Breast Cancer and the Impact of Testing on Surgical Decision Making.

Journal Article Am Surg · December 2023 BACKGROUND: Genetic testing is increasingly utilized in breast cancer patients; however, testing rates remain low. We aimed to evaluate the rate of genetic testing at a tertiary academic medical center utilizing a multidisciplinary clinic model including g ... Full text Link to item Cite

Changes in Surgical Management of the Axilla Over 11 Years - Report on More Than 1500 Breast Cancer Patients Treated with Neoadjuvant Chemotherapy on the Prospective I-SPY2 Trial.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Axillary surgery after neoadjuvant chemotherapy (NAC) is becoming less extensive. We evaluated the evolution of axillary surgery after NAC on the multi-institutional I-SPY2 prospective trial. METHODS: We examined annual rates of sentinel lymph ... Full text Link to item Cite

How to Navigate the Treatment Spectrum from Multimodality Therapy to Observation Alone for ductal carcinoma in situ.

Journal Article Surg Oncol Clin N Am · October 2023 DCIS detection has increased dramatically since the introduction of screening mammography. Current guidance concordant care recommends surgical intervention for all patients with DCIS, followed by radiation and/or endocrine therapy for some. Adjuvant thera ... Full text Link to item Cite

Does Preoperative MRI Reduce Positive Margins after Breast-Conserving Surgery?

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Breast-conserving surgery (BCS) is a mainstay for breast cancer management, and obtaining negative margins is critical. Some have advocated for the use of preoperative magnetic resonance imaging (MRI) in reducing positive margins after BCS. We ... Full text Link to item Cite

Examining the Impact of Cholecystectomy on Tumor Recurrence in Breast Cancer Patients.

Journal Article Am Surg · September 2023 Previous studies have found that bile acids influence the growth of breast cancer cells in vitro, suggesting that naturally occurring bile acids may also influence the growth of human breast cancer cells. Cholecystectomy alters modulation of bile acid meta ... Full text Link to item Cite

Are Breast Cancer Patients Presenting With Higher Stage Since the COVID-19 Pandemic?

Journal Article Am Surg · September 2023 The impact of the COVID-19 pandemic on health care is vast and continuing to unfold. As much progress related to breast cancer has resulted from screening and public health measures, we analyzed the stage at which patients with breast cancer presented for ... Full text Link to item Cite

Breast Conservation Surgery and Mastectomy Have Similar Locoregional Recurrence After Neoadjuvant Chemotherapy: Results From 1462 Patients on the Prospective, Randomized I-SPY2 Trial.

Journal Article Ann Surg · September 1, 2023 Neoadjuvant chemotherapy (NAC) increases rates of successful breast-conserving surgery (BCS) in patients with breast cancer. However, some studies suggest that BCS after NAC may confer an increased risk of locoregional recurrence (LRR). We assessed LRR rat ... Full text Link to item Cite

Simultaneous Detection of Multiple Tumor-targeted Gold Nanoparticles in HER2-Positive Breast Tumors Using Optoacoustic Imaging.

Journal Article Radiol Imaging Cancer · May 2023 Purpose To develop optoacoustic, spectrally distinct, actively targeted gold nanoparticle-based near-infrared probes (trastuzumab [TRA], TRA-Aurelia-1, and TRA-Aurelia-2) that can be individually identifiable at multispectral optoacoustic tomography (MSOT) ... Full text Link to item Cite

Abstract P3-05-20: Low 21-Gene Recurrence Score Is Not Associated with a High Axillary Nodal Burden in Post-Menopausal Women Presenting with a Clinically Negative Axilla

Conference Cancer Research · March 1, 2023 AbstractBackground: The predictive and prognostic value of the 21-gene recurrence score (RS) has emphasized the importance of tumor biology and minimized the credence of a limited (1-3 positive) nodal burden ... Full text Cite

Abstract P1-06-02: The effect of race on pathologic complete response rates and overall survival in patients with triple negative breast cancer

Conference Cancer Research · March 1, 2023 AbstractIntroduction: Despite the recent overall improvement in survival for patients with breast cancer, racial disparities in outcomes persist. While studies have demonstrated that socioeconomic factors an ... Full text Cite

ShouldStage IA Breast Cancerbe Expanded?

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

High Risk Screening in Women with BRCA1/2 Mutations Age 70 and Above

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

Does Localization Technique Matter for Non-palpable Breast Cancers?

Journal Article Am Surg · December 2022 BACKGROUND: There are several techniques for localization of non-palpable breast tumors, but comparisons of these techniques in terms of margin positivity and volume of tissue resected are lacking. METHODS: Between 2011-2013 and 2016-2018, 2 randomized con ... Full text Link to item Cite

Infertility: A Hidden Cost of Medical Training.

Journal Article J Grad Med Educ · December 2022 Full text Link to item Cite

Omission of Radiation in Conservative Treatment for Breast Cancer: Opportunity for De-escalation of Care.

Journal Article J Surg Res · November 2022 INTRODUCTION: De-escalation of breast cancer treatment aims to reduce patient and financial toxicity without compromising outcomes. Level I evidence and National Comprehensive Cancer Network guidelines support omission of adjuvant radiation in patients age ... Full text Link to item Cite

Intestinal Microbiota Influence Doxorubicin Responsiveness in Triple-Negative Breast Cancer.

Journal Article Cancers (Basel) · October 4, 2022 Triple-negative breast cancer (TNBC) is highly aggressive with a poor 5-year survival rate. Targeted therapy options are limited and most TNBC patients are treated with chemotherapy. This study aimed to determine whether doxorubicin (Dox) shifts the gut mi ... Full text Link to item Cite

Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia Necessitating Mastectomy.

Journal Article Am Surg · August 2022 Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon, benign breast lesion often diagnosed incidentally and frequently mistaken for fibroadenoma given similar radiographic appearance. Histopathology classically reveals diffuse, dense fibrous stromal ... Full text Link to item Cite

Primary Breast Neuroendocrine Tumor.

Journal Article Am Surg · August 2022 Breast primary neuroendocrine tumors (BNETs) are rare, making up less than 1% of all breast carcinoma diagnosis. Their detection relies on physical exams and mammography. Diagnosis of primary BNET requires findings of no other source of neuroendocrine tumo ... Full text Link to item Cite

Intraductal Papilloma on Breast Biopsy: Upstaging Rate and Implications for Practice Guidelines.

Journal Article Am Surg · July 2022 BACKGROUND: The recommendation for management of intraductal papilloma has not been clearly established and its surgical excision criteria remain controversial. This study determines the institutional malignancy upstage rate of benign intraductal papilloma ... Full text Link to item Cite

Does Breast Cancer Subtype Impact Margin Status in Patients Undergoing Partial Mastectomy?

Journal Article Am Surg · July 2022 BACKGROUND: Molecular subtype in invasive breast cancer guides systemic therapy. It is unknown whether molecular subtype should also be considered to tailor surgical therapy. The present investigation was designed to evaluate whether breast cancer subtype ... Full text Link to item Cite

Are we choosing wisely? Drivers of preoperative MRI use in breast cancer patients.

Journal Article Am J Surg · July 2022 INTRODUCTION: Factors contributing to the use of preoperative MRI remain poorly understood. METHODS: Data from a randomized controlled trial of stage 0-3 breast cancer patients undergoing breast conserving surgery between 2016 and 2018 were analyzed. RESUL ... Full text Link to item Cite

Impact of the COVID-19 Pandemic on Breast Cancer Screening and Operative Treatment.

Journal Article Am Surg · June 2022 INTRODUCTION: The COVID-19 pandemic has impacted many areas of health care and had a significant impact on care delivery, including breast cancer. METHODS: To better understand the changes to detection and treatment of breast cancer at our institution, we ... Full text Link to item Cite

Upstage Rate of Complex Sclerosing Lesions/Radial Scars.

Journal Article Am Surg · May 2022 BACKGROUND: Radial scars (RS) and complex sclerosing lesions (CSL) are breast radiologic findings described as small, stellate lesions causing architectural distortion. This can mimic malignancy. Core needle biopsy (CNB) is often performed. Advances in bre ... Full text Link to item Cite

Factors Affecting Time to Surgery in Breast Cancer Patients.

Journal Article Am Surg · April 2022 BACKGROUND: We sought to determine factors affecting time to surgery (TTS) to identify potential modifiable factors to improve timeliness of care. METHODS: Patients with clinical stage 0-3 breast cancer undergoing partial mastectomy in 2 clinical trials, c ... Full text Link to item Cite

Evaluation of the Axillary Surgery Performed in Clinically Node-Positive Breast Cancer Patients Following Neoadjuvant Chemotherapy.

Journal Article Am Surg · April 2022 BACKGROUND: The American College of Surgeons Oncology Group Z1071 trial in 2013 demonstrated the fesability of sentinel lymph node biopsy in clinically node-positive patients following neoadjuvant chemotherapy. The goal of this study was to determine the c ... Full text Link to item Cite

Ductal Carcinoma In Situ in Pregnant Women.

Journal Article Chirurgia (Bucur) · December 2021 Breast cancer is the second most common malignancy affecting pregnant women. Ductal carcinoma in situ (DCIS) during pregnancy has not been well described with limited literature addressing the optimal treatment options. This is important topic as the incid ... Full text Link to item Cite

Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis.

Journal Article Cancer Res · July 15, 2021 Obesity and poor diet often go hand-in-hand, altering metabolic signaling and thereby impacting breast cancer risk and outcomes. We have recently demonstrated that dietary patterns modulate mammary microbiota populations. An important and largely open ques ... Full text Link to item Cite

Treatment and Outcomes of Women With Large Locally Advanced Breast Cancer.

Journal Article Am Surg · May 2021 Advances in breast cancer research have made breast cancer a treatable disease. However, there is a population of women who present with large, advanced, or sometimes neglected breast cancers who can prove difficult to treat. These women often require mult ... Full text Link to item Cite

Resection of Cavity Shave Margins in Stage 0-III Breast Cancer Patients Undergoing Breast Conserving Surgery: A Prospective Multicenter Randomized Controlled Trial.

Journal Article Ann Surg · May 1, 2021 OBJECTIVE: Single-center studies have demonstrated that resection of cavity shave margins (CSM) halves the rate of positive margins and re-excision in breast cancer patients undergoing partial mastectomy (PM). We sought to determine if these findings were ... Full text Link to item Cite

Impact of Cavity Shave Margins on Margin Status in Patients with Pure Ductal Carcinoma In Situ.

Journal Article J Am Coll Surg · April 2021 BACKGROUND: We examined the impact of cavity shave margins (CSMs) on margin status in patients with pure ductal carcinoma in situ (DCIS) undergoing partial mastectomy (PM). METHODS: One hundred and nine patients from 2 multicenter, randomized controlled tr ... Full text Link to item Cite

Is Excisional Biopsy Needed for Pure FEA Diagnosed on a Core Biopsy?

Journal Article Am Surg · September 2020 BACKGROUND: The management of flat epithelial atypia (FEA) on core needle biopsy remains controversial. The upstaging rates after surgical excision are variable. In this study, we seek to determine the upstaging rate of FEA at our institution. METHODS: Pat ... Full text Link to item Cite

Is Sentinel Lymph Node Biopsy Necessary for Ductal Carcinoma In Situ Patients Undergoing Mastectomy?

Journal Article Am Surg · August 2020 BACKGROUND: Current treatment guidelines for ductal carcinoma in situ (DCIS) treated with mastectomy recommend sentinel lymph node biopsy (SLNB). In the modern era, there is a trend toward minimizing invasive staging and treatment of the axilla. In this st ... Full text Link to item Cite

Neoadjuvant Chemotherapy Shifts Breast Tumor Microbiota Populations to Regulate Drug Responsiveness and the Development of Metastasis.

Journal Article Mol Cancer Res · January 2020 Breast tumors have their own specific microbiota, distinct from normal mammary gland tissue. Patients with breast cancer that present with locally advanced disease often undergo neoadjuvant chemotherapy to reduce tumor size prior to surgery to allow breast ... Full text Link to item Cite

Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle.

Journal Article Biomaterials · November 2018 At the intersection of the newly emerging fields of optoacoustic imaging and theranostic nanomedicine, promising clinical progress can be made in dismal prognosis of ovarian cancer. An acidic pH targeted wormhole mesoporous silica nanoparticle (V7-RUBY) wa ... Full text Link to item Cite

Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations.

Journal Article Cell Rep · October 2, 2018 Recent identification of a mammary gland-specific microbiome led to studies investigating bacteria populations in breast cancer. Malignant breast tumors have lower Lactobacillus abundance compared with benign lesions, implicating Lactobacillus as a negativ ... Full text Link to item Cite

Applying dynamic contrast enhanced MSOT imaging to intratumoral pharmacokinetic modeling

Journal Article Photoacoustics · September 1, 2018 Examining the dynamics of an agent in the tumor microenvironment can offer critical insights to the influx rate and accumulation of the agent. Intratumoral kinetic characterization in the in vivo setting can further elicudate distribution patterns and tumo ... Full text Cite

Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study.

Journal Article BMC Cancer · July 30, 2018 BACKGROUND: There has been interest in the potential benefit of vitamin D (VD) to improve breast cancer outcomes. Pre-clinical studies suggest VD enhances chemotherapy-induced cell death. Vitamin D deficiency was associated with not attaining a pathologic ... Full text Link to item Cite

Temozolomide enhances triple-negative breast cancer virotherapy in vitro

Journal Article Cancers · May 1, 2018 Triple-negative breast cancer (TNBC) is one of the most aggressive types of cancer, and treatment is limited to chemotherapy and radiation. Oncolytic virotherapy may be a promising approach to treat TNBC. However, oncolytic adenovirus (OAd)-based mono-ther ... Full text Cite

The impact of obesity on outcomes for patients undergoing mastectomy using the ACS-NSQIP data set.

Journal Article Breast Cancer Res Treat · April 2018 PURPOSE: According to the World Health Organization (WHO), 34.7% of females in the United States are obese (BMI ≥ 30) in 2014, compared to 32.5% in 2010. The previous research has demonstrated high BMI as an independent risk factor for surgical complicatio ... Full text Link to item Cite

Serum Vitamin D Levels Affect Pathologic Complete Response in Patients Undergoing Neoadjuvant Systemic Therapy for Operable Breast Cancer.

Journal Article Clin Breast Cancer · April 2018 INTRODUCTION: There has been increasing interest in the potential benefit of vitamin D in improving breast cancer outcome. Preclinical studies suggest that vitamin D enhances chemotherapy-induced cell death. We investigated the impact of serum vitamin D le ... Full text Link to item Cite

Osteopontin-targeted probe detects orthotopic breast cancers using optoacoustic imaging.

Journal Article Biotech Histochem · 2018 Improved detection of breast cancer using highly sensitive, tumor-specific imaging would facilitate diagnosis, surveillance and assessment of response to treatment. We conjugated osteopontin peptide to an infrared fluorescent dye to serve as a contrast age ... Full text Link to item Cite

Trends in Neoadjuvant Endocrine Therapy Use and Impact on Rates of Breast Conservation in Hormone Receptor-Positive Breast Cancer: A National Cancer Data Base Study.

Journal Article Ann Surg Oncol · February 2017 BACKGROUND: The American College of Surgeons Oncology Group Z1031 trial demonstrated that neoadjuvant endocrine therapy (NET) increased breast-conserving surgery (BCS) rates for postmenopausal patients with clinical tumor stage 2-4c estrogen receptor-posit ... Full text Link to item Cite

Impact that Timing of Genetic Mutation Diagnosis has on Surgical Decision Making and Outcome for BRCA1/BRCA2 Mutation Carriers with Breast Cancer.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: Deleterious BRCA mutation carriers with breast cancer are at increased risk for additional breast cancer events. This study evaluated the impact that timing of identification of BRCA+ status has on surgical decision and outcome. METHODS: The au ... Full text Link to item Cite

Nipple-sparing mastectomy: To spare or not to spare?

Journal Article Current Surgery Reports · May 1, 2016 The use of nipple-sparing mastectomy for prophylactic and therapeutic purposes has increased in recent years primarily driven by patient desire for improved esthetics. This article aims to critically review indications, oncologic safety, and recent advance ... Full text Cite

Sunao Tawara, a cardiac pathophysiologist.

Journal Article Clin Anat · January 2008 Full text Link to item Cite

A Phase I study of concurrent RMP-7 and carboplatin with radiation therapy for children with newly diagnosed brainstem gliomas.

Journal Article Cancer · November 1, 2005 BACKGROUND: Ninety percent of children with diffuse, intrinsic brainstem tumors will die within 18 months of diagnosis. Radiotherapy is of transient benefit to these children, and a potential way to improve its efficacy is to add radiosensitizers. Carbopla ... Full text Link to item Cite

Phase 1 study of concurrent RMP-7 and carboplatin with radiotherapy for children with newly diagnosed brainstem gliomas.

Journal Article Cancer · September 15, 2005 BACKGROUND: Ninety percent of children with diffuse intrinsic brainstem tumors will die within 18 months of diagnosis. Radiotherapy is of transient benefit, and one way to potentially improve its efficacy is to add radiosensitizers. Carboplatin is antineop ... Full text Link to item Cite