Scholars@Duke
Andrew Muzyk

Andrew Muzyk

Associate Professor of the Practice of Medical Education
Medical Education
andrew.muzyk@duke.edu
Duke Box 3089, Durham, NC 27710
14221 Duke South, Red Zone, Box 3089, Durham, NC 27710

Selected Publications

Development of a curricular thread to foster medical students' critical reflection and promote action on climate change, health, and equity.

Journal Article PLoS One · 2024 INTRODUCTION: Due to the health consequences arising from climate change, medical students will inevitably interact with affected patients during their training and careers. Accordingly, medical schools must incorporate education on the impacts of climate ... Full text Open Access Link to item Cite

Real-world treatment patterns of patients with major depressive disorder treated with Auvelity in the United States.

Journal Article J Med Econ · 2024 AIMS: Major depressive disorder (MDD) is a prevalent, chronic disorder. Auvelity (dextromethorphan-bupropion) is a novel, oral N-methyl-D-aspartate (NMDA) receptor antagonist and sigma-1 receptor agonist approved (August 2022) by the FDA for treating MDD i ... Full text Link to item Cite

Dextromethorphan-bupropion (Auvelity) for the Treatment of Major Depressive Disorder.

Journal Article Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · November 2023 Depression is a significant cause of morbidity and mortality globally. Although various pharmacologic options exist for depression, treatments are limited by delayed or incomplete therapeutic response, low rates of remission, and adverse effects necessitat ... Full text Cite

Interprofessional Climate Change Curriculum in Health Professional Programs: A Scoping Review

Journal Article Education Sciences · September 1, 2023 Background: We conducted this scoping review to (1) comprehensively compile the published literature on interprofessional education focused on climate change and health, (2) assess the quality and outcomes of the existing curriculum interventions, and (3) ... Full text Cite

Sublingual Dexmedetomidine for the Treatment of Agitation in Patients with Schizophrenia and Bipolar Disorder.

Journal Article Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · May 2023 Acute agitation is common amongst individuals with bipolar disorder and schizophrenia and represents a medical emergency. Commonly used medications for agitation, such as benzodiazepines and antipsychotics, are often delivered intramuscularly and may cause ... Full text Cite

Transformative Learning and Critical Consciousness: A Model for Preclerkship Medical School Substance Use Disorder Education.

Journal Article Acad Psychiatry · April 2023 OBJECTIVE: Preparing medical students to provide compassionate person-centered care for people with substance use disorders (SUD) requires a re-envisioning of preclerkship SUD education to allow for discussions on stigma, social determinants of health, sys ... Full text Open Access Link to item Cite

Assessing changes in the quality of quantitative health educations research: a perspective from communities of practice.

Journal Article BMC medical education · April 2022 BackgroundAs a community of practice (CoP), medical education depends on its research literature to communicate new knowledge, examine alternative perspectives, and share methodological innovations. As a key route of communication, the medical edu ... Full text Cite

Substance use-related continuing education course objectives: Alignment with professional competencies.

Journal Article Substance abuse · January 2022 Background: Novel educational efforts are needed to prepare the current and future interprofessional health care workforce to address the range of substance use-related health problems. A 6-module massive open online course (MOOC) was developed to p ... Full text Cite

Increasing Naloxone Prescribing in the Emergency Department Through Education and Electronic Medical Record Work-Aids.

Journal Article Jt Comm J Qual Patient Saf · June 2021 BACKGROUND: Emergency department (ED) visits for opioid overdose continue to rise. Evidence-based harm reduction strategies for opioid use disorder (OUD), such as providing home naloxone, can save lives, but ED implementation remains challenging. METHODS: ... Full text Link to item Cite

Pharmacological agents to treat severe neuropsychiatric symptoms in major neurocognitive disorders.

Journal Article Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · May 2020 BackgroundBehavioral and psychological symptoms of dementia (BPSD) are challenging to recognize and treat effectively. Despite very effective nonpharmacologic strategies, there are cases where severe BPSD may require biological intervention. The p ... Cite

Behavior Change Counseling of Patients with Substance Use Disorders by Health Professions Students.

Journal Article Acad Psychiatry · April 2020 OBJECTIVE: The purpose of this project was to create an interprofessional substance use disorders (SUDs) course that provided health professions students an opportunity to acquire and apply behavior change counseling skills for patients with SUDs with dire ... Full text Link to item Cite

A Pilot Interprofessional Course on Substance Use Disorders to Improve Students' Empathy and Counseling Skills.

Journal Article Am J Pharm Educ · April 2020 Objective. To implement and assess the effectiveness of an interprofessional course designed to provide pharmacy and nursing students with opportunities to improve their understanding of substance use disorders (SUDs), assess their attitudes toward patient ... Full text Link to item Cite

Pharmacists and the opioid crisis: A narrative review of pharmacists' practice roles

Journal Article JACCP Journal of the American College of Clinical Pharmacy · March 1, 2020 Introduction: Nearly 2.5 million Americans have an opioid use disorder (OUD) related to prescription and/or illicit opioids. Pharmacists, as one of the most accessible care providers, are essential in mitigating the mortality and morbidity of the opioid ov ... Full text Open Access Cite

Interprofessional Substance Use Disorder Education in Health Professions Education Programs: A Scoping Review.

Journal Article Acad Med · March 2020 PURPOSE: The authors conducted this scoping review to (1) provide a comprehensive evaluation and summation of published literature reporting on interprofessional substance use disorder (SUD) education for students in health professions education programs a ... Full text Link to item Cite

Experiences and opinions of health professional students participating in an opioid use disorder educational event.

Journal Article The mental health clinician · March 2020 IntroductionThe objectives of this study were to describe health professional students' experiences and opinions about patients with opioid-use disorder (OUD), to summarize evaluation results from an OUD educational event and to compare results by ... Full text Cite

An Interprofessional Substance Use Disorder Course to Improve Students' Educational Outcomes and Patients' Treatment Decisions.

Journal Article Acad Med · November 2019 PURPOSE: Substance use is a public health concern. Health professions organizations recommend improvements in substance use disorder (SUD) education. Mezirow's transformative learning theory was used as the educational framework to develop a course that wo ... Full text Link to item Cite

Substance Use Disorder Education in Medical Schools: A Scoping Review.

Journal Article Academic medicine : journal of the Association of American Medical Colleges · November 2019 PurposeAs medical schools adapt their curricula to prepare future physicians for the opioid crisis and for treating patients with substance use disorders (SUDs), educators should refer to courses described in the literature. This scoping review ai ... Full text Cite

Pharmacists' attitudes toward dispensing naloxone and medications for opioid use disorder: A scoping review of the literature.

Journal Article Subst Abus · 2019 Background: Pharmacists are on the frontline caring for patients at risk of an opioid overdose and for patients with an opioid use disorder (OUD). Dispensing naloxone and medications for OUD and counseling patients about these medications are ways pharmaci ... Full text Open Access Link to item Cite

The Emergency Department as an Opportunity for Naloxone Distribution.

Journal Article The western journal of emergency medicine · November 2018 IntroductionSubstance use disorders, including opioid use disorders, are a major public health concern in the United States. Between 2005 and 2014, the rate of opioid-related emergency department (ED) visits nearly doubled, from 89.1 per 100,000 p ... Full text Open Access Cite

Substance Use Education in Schools of Nursing: A Systematic Review of the Literature.

Journal Article Nurse educator · May 2018 The authors systematically reviewed the nursing literature for articles describing substance use disorders (SUDs) education in schools of nursing. Five literature databases were searched, producing 3107 retrieved articles, of which 12 were included in this ... Full text Cite

Utilizing Bloom's taxonomy to design a substance use disorders course for health professions students.

Journal Article Subst Abus · 2018 BACKGROUND: Substance use disorders (SUDs) are a public health problem affecting millions of Americans. Despite their prevalence, there are few health care resources allocated for SUDs treatment. Relatively few health care professionals are exposed to SUDs ... Full text Link to item Cite

Surveys of substance use disorders education in US pharmacy programs.

Journal Article The mental health clinician · January 2018 IntroductionSubstance use disorders (SUDs) are a significant US health problem affecting roughly 20 million Americans, but there continues to be limited access to SUD treatment and inadequate addiction medicine training. Therefore, it is important ... Full text Cite

An Interprofessional Course on Substance Use Disorders for Health Professions Students.

Journal Article Acad Med · December 2017 PROBLEM: Substance use disorders (SUDs) affect millions of Americans. Nevertheless, there is insufficient health care resource allocation for these patients. One reason may be the lack of education and training about SUDs in health professions programs. AP ... Full text Link to item Cite

Substance use education in US schools of pharmacy: A systematic review of the literature.

Journal Article Substance abuse · October 2017 BackgroundThe authors sought to systematically review the quantity and quality of literature describing substance use disorders (SUDs) education in US schools of pharmacy and determine the effectiveness of the educational interventions employed. Full text Cite

Discharge Plans for Geriatric Inpatients with Delirium: A Plan to Stop Antipsychotics?

Journal Article J Am Geriatr Soc · October 2017 BACKGROUND: Studies show inpatient geriatric patients with reversible conditions like delirium may continue on antipsychotic medications without clear indications after hospital discharge. We conducted this study to determine how often geriatric patients w ... Full text Link to item Cite

Impact of an Alcohol Withdrawal Treatment Pathway on Hospital Length of Stay: A Retrospective Observational Study Comparing Pre and Post Pathway Implementation.

Journal Article J Psychiatr Pract · May 2017 OBJECTIVE: To determine if the implementation of a hospital-specific alcohol withdrawal treatment pathway used in a medical-surgical patient population decreased hospital length of stay (LOS) compared with the standard of care. METHODS: This retrospective ... Full text Link to item Cite

Development of a Diverse Learning Experience for Diverse Psychiatry Resident Needs: A Four-Year Biological Psychiatry Curriculum Incorporating Principles of Neurobiology, Psychopharmacology, and Evidence-Based Practice.

Journal Article Psychiatry Investig · May 2017 OBJECTIVE: A clinically relevant approach to patient care grounded in neurobiological constructs and evidence based practice which emphasizes a relevant psychopharmacology is needed to optimally train psychiatry residents. METHODS: We implemented a biologi ... Full text Link to item Cite

The Role of Pharmacists in the Opioid Epidemic: An Examination of Pharmacist-Focused Initiatives Across the United States and North Carolina.

Journal Article North Carolina medical journal · May 2017 A pharmacy presence on national, state, and local levels is helping to address the opioid epidemic. This article will comment on and examine how pharmacists are working together with the health care team and community to address the opioid crisis. ... Full text Cite

Emphasizing Bloom's Affective Domain to Reduce Pharmacy Students' Stigmatizing Attitudes.

Journal Article Am J Pharm Educ · March 25, 2017 Objective. To create a learning environment using Bloom's affective domain as a framework that would reduce third-year pharmacy students' stigmatizing attitudes toward patients with mental illness. Design. Prior to the start of the module, students were as ... Full text Link to item Cite

Tardive dyskinesia: 21st century may bring new treatments to a forgotten disorder.

Journal Article Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · February 2017 Cite

Examination of QTc Values in Critically Ill Patients Diagnosed with Delirium and Prescribed Atypical Antipsychotics.

Journal Article Current drug safety · January 2017 ObjectiveTo determine the extent of QTc prolongation following administration of an atypical antipsychotic in critically ill patients diagnosed with delirium and to conduct an assessment of risk factors to identify the presence of specific risk fa ... Full text Cite

Bipolar Depression: Pregnancy, Postpartum, and Lactation.

Journal Article Psychiatr Clin North Am · March 2016 Medication management of bipolar depression in pregnancy and lactation is best done by assessing each patient's and family's needs in detail. Keeping pregnant patients as psychiatrically stable as possible is the most important principle for clinicians. Un ... Full text Open Access Link to item Cite

Prolonged Delirium With Catatonia Following Orthotopic Liver Transplant Responsive to Memantine.

Journal Article J Psychiatr Pract · March 2016 A 59-year-old man with nonalcoholic steatohepatitis cirrhosis underwent an orthotopic liver transplant and experienced a complicated postoperative course, including a prolonged delirium. After discharge to rehabilitation, he had 2 subsequent admissions for ... Full text Link to item Cite

Evaluation of Changes in Citalopram Prescribing Patterns Following a US Food and Drug Administration Alert: A Retrospective Cohort Study.

Journal Article Prim Care Companion CNS Disord · 2015 OBJECTIVE: The US Food and Drug Administration (FDA) issued a warning stating that patients older than 60 years are not recommended to receive doses of citalopram exceeding 20 mg daily due to concerns of corrected QT (QTc) prolongation. The purpose of this ... Full text Link to item Cite

Implementation of a flipped classroom model to teach psychopharmacotherapy to third-year doctor of pharmacy (PharmD) students

Journal Article Pharmacy Education · January 1, 2015 Objective: To implement a flipped classroom model centred on student-led active learning to teach psychopharmacotherapy in a third-year pharmacotherapeutics course. Design: The psychopharmacotherapeutic module was conducted over a two week period during th ... Cite

Defining the Role of Dexmedetomidine in the Prevention of Delirium in the Intensive Care Unit.

Journal Article Biomed Res Int · 2015 Dexmedetomidine is a highly selective α 2 agonist used as a sedative agent. It also provides anxiolysis and sympatholysis without significant respiratory compromise or delirium. We conducted a systematic review to examine whether sedation of patients in th ... Full text Link to item Cite

Dexmedetomidine for the treatment of alcohol withdrawal syndrome: rationale and current status of research.

Journal Article CNS Drugs · November 2013 Dexmedetomidine is currently used in the US in the treatment of alcohol withdrawal syndrome (AWS) in the intensive care unit (ICU) setting, although data to support this practice are limited. Dexmedetomidine targets the noradrenergic system, an important b ... Full text Link to item Cite

A psychopharmacology course for psychiatry residents utilizing active-learning and residents-as-teachers to develop life-long learning skills.

Journal Article Acad Psychiatry · September 2013 OBJECTIVE: The authors describe the implementation and evaluation of a 1-year psychopharmacology course using residents-as-teachers and active-learning exercises intended to improve understanding of current psychopharmacology and its evidence base, and ski ... Full text Link to item Cite

Quetiapine for the treatment of delirium.

Journal Article Journal of hospital medicine · April 2013 BackgroundDelirium is associated with high rates of morbidity and mortality in hospitalized medically ill patients. Haloperidol has historically been the agent of choice for the treatment of delirium, but recent studies have explored the efficacy ... Full text Cite

The role of diazepam loading for the treatment of alcohol withdrawal syndrome in hospitalized patients.

Journal Article The American journal on addictions · March 2013 BackgroundAlcohol withdrawal accounts for a significant amount of hospital admissions and can quickly progress to the development of delirium tremens (DTs), seizures, and death. Rapid identification and management of alcohol withdrawal syndrome (A ... Full text Cite

Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review.

Journal Article Clin Pharmacol · 2013 Baclofen, an agonist at the B subunit of gaba-aminobutyric acid receptor, possesses pharmacologic properties that may confer utility for the treatment of alcohol dependence. Research suggests that not only can it be useful in promoting maintenance of alcoh ... Full text Link to item Cite

A computerized physician order entry set designed to improve safety of intravenous haloperidol utilization: a retrospective study in agitated hospitalized patients.

Journal Article Drug Saf · September 1, 2012 BACKGROUND: Intravenous haloperidol can increase the risk for corrected QT (QTc) interval prolongation, torsades de pointes (TdP) and sudden death. OBJECTIVE: The purpose of this study was to examine the effects of implementation of a computerized physicia ... Full text Link to item Cite

Examination of baseline risk factors for QTc interval prolongation in patients prescribed intravenous haloperidol.

Journal Article Drug Saf · July 1, 2012 BACKGROUND: Intravenous haloperidol can increase the risk for corrected QT interval (QTc) prolongation, torsades de pointes (TdP) and sudden death. There are a number of risk factors reported in the literature for QTc prolongation and TdP with intravenous ... Full text Link to item Cite

Prevalence of baseline lipid monitoring in patients prescribed second-generation antipsychotics during their index hospitalization: a retrospective cohort study.

Journal Article Gen Hosp Psychiatry · 2012 BACKGROUND: Second-generation antipsychotics have been found to increase a patient's risk of dyslipidemia. Despite consensus statement recommendations for lipid monitoring, studies indicate that up to 90% of patients still do not have a baseline lipid pane ... Full text Link to item Cite

Defining the role of baclofen for the treatment of alcohol dependence: a systematic review of the evidence.

Journal Article CNS Drugs · January 1, 2012 The pharmacological properties of baclofen, a GABA(B) receptor agonist, have led to investigation of its use for the off-label treatment of alcohol dependence. Literature examining the role of baclofen in alcohol dependence suggests that it may be a useful ... Full text Link to item Cite

The use of dexmedetomidine in alcohol withdrawal.

Journal Article The Journal of neuropsychiatry and clinical neurosciences · January 2012 Full text Cite

Metoclopramide-induced tardive respiratory dyskinesia.

Journal Article The Journal of neuropsychiatry and clinical neurosciences · January 2012 Full text Cite

Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity.

Journal Article The Journal of neuropsychiatry and clinical neurosciences · January 2012 Full text Cite

Testosterone supplementation for hypoactive sexual desire disorder in women.

Journal Article Pharmacotherapy · January 2012 Over 50% of women are believed to be affected by female sexual dysfunction (FSD). When particularly distressful, FSD is known as hypoactive sexual desire disorder (HSDD). In contrast to male sexual dysfunction that has been extensively researched, there is ... Full text Cite

Lithium-induced renal ectasia.

Journal Article J Neuropsychiatry Clin Neurosci · 2012 Full text Link to item Cite

Role of α2-agonists in the treatment of acute alcohol withdrawal.

Journal Article The Annals of pharmacotherapy · May 2011 ObjectiveTo evaluate literature reporting on the role of norepinephrine in alcohol withdrawal and to determine the safety and efficacy of α(2)-agonists in reducing symptoms of this severe condition.Data sourcesArticles evaluating the effi ... Full text Cite

Interferences with urine drug screens.

Journal Article Journal of pharmacy practice · February 2011 Qualitative urine drug assays are frequently used in conjunction with opioid contracts as a means of monitoring use of prescribed controlled substances as well as concurrent use of illicit substances in patients receiving opioids for chronic nonmalignant p ... Full text Cite

A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.

Journal Article Gen Hosp Psychiatry · 2011 We report a case of delirium accompanied by extrapyramidal symptoms and autonomic dysfunction in a 59-year-old man following abrupt cessation of baclofen and tizanidine. An extensive search for the etiology was undertaken, but it was only after a careful h ... Full text Link to item Cite

Use of aripiprazole in a patient with multiple sclerosis presenting with paranoid psychosis.

Journal Article J Psychiatr Pract · November 2010 Multiple sclerosis (MS) is an autoimmune neurodegenerative disorder of the central nervous system (CNS). A significant percentage of MS patients will develop neuropsychiatric symptoms during their lifetime; affective symptoms are most common, but psychosis ... Full text Link to item Cite

Drug interaction between carbapenems and extended-release divalproex sodium in a patient with schizoaffective disorder.

Journal Article General hospital psychiatry · September 2010 BackgroundClinicians prescribing divalproex sodium (DVX) are well aware of its potential to cause a drug-drug interaction. One specific interaction occurs between the carbapenem antibiotics and DVX resulting in decreased valproic acid (VPA) levels ... Full text Cite

Use of lamotrigine in a patient with a clozapine-related seizure.

Journal Article Journal of psychiatric practice · March 2010 Seizures can be a serious adverse effect of clozapine, often a last-resort antipsychotic with unique efficacy for some patients. Several anticonvulsants have been reported to be useful in preventing further clozapine-induced seizures and permitting continu ... Full text Cite

Serotonin syndrome after a massive overdose of controlled-release paroxetine.

Journal Article Psychosomatics · 2010 BACKGROUND: Serotonin syndrome is a condition resulting from an overabundance of serotonin at postsynaptic receptors. The syndrome usually responds to cyproheptadine and benzodiazepines. However, some patients do not respond to conventional treatment. OBJE ... Full text Link to item Cite

Topiramate-induced confusion following a single ingestion of 400 mg.

Journal Article Gen Hosp Psychiatry · 2010 BACKGROUND: Topiramate is an anticonvulsant medication commonly used for a variety of neurological disorders including migraine prophylaxis. Broadened use of topiramate has brought an increased awareness of toxicity from this medication, particularly centr ... Full text Link to item Cite

Antidepressants and osteoporosis

Journal Article Psychopharm Review · August 1, 2009 Full text Cite

Counseling Spanish-speaking patients: Atlanta pharmacists' cultural sensitivity, use of language-assistance services, and attitudes.

Journal Article Journal of the American Pharmacists Association : JAPhA · May 2004 ObjectiveTo document the types of language-assistance services available in pharmacies and the perceptions of pharmacists regarding the effectiveness of these services, and to measure the attitudes toward counseling Spanish-speaking patients and c ... Full text Cite