Scholars@Duke
Sanjay Girdhari Asrani

Sanjay Girdhari Asrani

Professor of Ophthalmology
Ophthalmology, Glaucoma
asran002@mc.duke.edu
Box 3802 Med Ctr, Durham, NC
Dept of Ophthalmology, Box 3802, Durham, NC 27710

Selected Publications

Posterior Vitreous Detachment and Risk of Neovascular Glaucoma in Eyes with Prior Retinal Vascular Occlusions

Journal Article Ophthalmology and Therapy · November 1, 2024 Introduction: To investigate the impact of posterior vitreous detachment (PVD) on the risk of developing neovascular glaucoma (NVG) in eyes with occlusions of the retinal artery (RAO) or retinal vein (RVO). Methods: Single-center retrospective case-control ... Full text Cite

The relationship between intraocular pressure and glaucoma: An evolving concept.

Journal Article Prog Retin Eye Res · September 19, 2024 Intraocular pressure (IOP) is the most important modifiable risk factor for glaucoma and fluctuates considerably within patients over short and long time periods. Our field's understanding of IOP has evolved considerably in recent years, driven by tonometr ... Full text Link to item Cite

Optical Coherence Tomography Findings in Glaucoma With Coexisting Vitamin A Deficiency.

Journal Article J Glaucoma · July 1, 2024 This case study reports on the presence of vitamin A deficiency in an adult with asymmetric normal tension glaucoma. The retinal OCT findings demonstrated not only expected loss of the outer retinal layers, typically seen in vitamin A deficiency, but also ... Full text Link to item Cite

Treatment of Primary Angle-Closure Suspect.

Journal Article JAMA Ophthalmol · May 1, 2024 Full text Link to item Cite

Agreement Between Trend-Based and Qualitative Analysis of the Retinal Nerve Fiber Layer Thickness for Glaucoma Progression on Spectral-Domain Optical Coherence Tomography

Journal Article Ophthalmology and Therapy · September 1, 2021 Introduction: To evaluate the agreement between trend-based analysis and qualitative assessment of the retinal nerve fiber layer (RNFL) thickness for glaucomatous progression on spectral-domain optical coherence tomography (SDOCT). Methods: Retrospective r ... Full text Cite

Rates of Glaucomatous Structural and Functional Change From a Large Clinical Population: The Duke Glaucoma Registry Study.

Journal Article Am J Ophthalmol · February 2021 PURPOSE: To investigate rates of structural and functional change in a large clinical population of glaucoma and glaucoma suspect patients. DESIGN: Retrospective cohort. METHODS: Twenty-nine thousand five hundred forty-eight spectral-domain optical coheren ... Full text Link to item Cite

Impact of Artifacts From Optical Coherence Tomography Retinal Nerve Fiber Layer and Macula Scans on Detection of Glaucoma Progression.

Journal Article Am J Ophthalmol · January 2021 PURPOSE: To determine the prevalence of artifacts on segmented spectral-domain optical coherence tomography (SDOCT) images and assess their impact on the interpretation of glaucomatous progression in the retinal nerve fiber layer (RNFL) profile and macular ... Full text Link to item Cite

Reticular Bullous Epithelial Edema in Corneas Treated with Netarsudil: A Case Series.

Journal Article Am J Ophthalmol · September 2020 PURPOSE: To describe the patient characteristics and the clinical course of an unusual reticular pattern of bullous epithelial corneal edema in a series of patients treated with netarsudil. DESIGN: Retrospective case series. METHODS: Case series at a singl ... Full text Link to item Cite

Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2.

Journal Article Adv Ther · April 2020 INTRODUCTION: New open-angle glaucoma (OAG) and ocular hypertension (OHT) therapies that reduce treatment burden and improve outcomes relative to currently available agents are needed. Netarsudil, a novel Rho kinase inhibitor approved by the US Food and Dr ... Full text Link to item Cite

Recurrent Tube Erosions with Anti-Vascular Endothelial Growth Factor Therapy in Patients with Age-Related Macular Degeneration.

Journal Article Ophthalmol Glaucoma · 2020 PURPOSE: To determine the rates of primary and recurrent glaucoma tube shunt erosions in patients with age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor (VEGF) intravitreal injections. DESIGN: Retrospective case serie ... Full text Link to item Cite

Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Three-Month Data from a Randomized Phase 3 Trial.

Journal Article Am J Ophthalmol · November 2019 PURPOSE: To compare the ocular hypotensive efficacy and safety of a fixed-dose combination (FDC) of the Rho kinase inhibitor netarsudil and latanoprost vs monotherapy with netarsudil or latanoprost. DESIGN: Three-month primary endpoint analysis of a random ... Full text Link to item Cite

IDENTIFICATION OF POSTERIOR SEGMENT PATHOLOGY WITH EN FACE RETINAL IMAGING USING MULTICOLOR CONFOCAL SCANNING LASER OPHTHALMOSCOPY.

Journal Article Retina · May 2019 PURPOSE: To assess posterior segment findings on multicolor confocal scanning laser ophthalmoscopy by correlation with spectral domain optical coherence tomography (SD-OCT) and to quantify agreement between these imaging modalities. METHODS: Retrospective ... Full text Link to item Cite

Possible Undiagnosed Glaucoma Detected by MultiColor Imaging of Retinal Diseases.

Journal Article Ophthalmol Glaucoma · 2019 PURPOSE: To evaluate for the presence of visible retinal nerve fiber layer (RNFL) defects consistent with undiagnosed glaucoma in MultiColor images (Heidelberg Engineering, Heidelberg, Germany) obtained at clinicians' discretion for the diagnosis and manag ... Full text Link to item Cite

Factors Associated with Interventions after Laser Peripheral Iridotomy for Primary Angle-Closure Spectrum Diagnoses.

Journal Article Ophthalmol Glaucoma · 2019 PURPOSE: To assess factors associated with receipt of subsequent medical, laser, or surgical interventions after laser peripheral iridotomy (LPI). DESIGN: Retrospective review. PARTICIPANTS: A total of 1271 eyes in 692 subjects with narrow angles (NAs) tha ... Full text Link to item Cite

Risk Factors Associated with Missed Diagnoses of Narrow Angles by the Van Herick Technique.

Journal Article Ophthalmol Glaucoma · 2018 PURPOSE: To identify which factors are associated with a deep-appearing anterior chamber on slit-lamp examination by the Van Herick (VH) technique in eyes with a diagnosis of narrow angle (NA) on gonioscopy. DESIGN: Retrospective review. PARTICIPANTS: One ... Full text Link to item Cite

Characterization of Artifacts Associated With Multicolor Confocal Scanning Laser Ophthalmoscopy.

Journal Article Ophthalmic Surg Lasers Imaging Retina · October 1, 2017 BACKGROUND AND OBJECTIVE: To characterize the appearance of three types of artifacts observed on multicolor confocal scanning laser ophthalmoscopy (cSLO). PATIENTS AND METHODS: Retrospective review of 159 eyes of 96 consecutive patients from the Duke Eye C ... Full text Link to item Cite

Feasibility of laser trabeculoplasty in angle closure glaucoma: a review of favourable histopathological findings in narrow angles.

Journal Article Clin Exp Ophthalmol · August 2017 Selective laser trabeculoplasty (SLT) has been indicated as a safe and efficient treatment for primary open-angle glaucoma; however, recent studies have also shown positive results with the use of SLT in some clinical conditions related to primary angle-cl ... Full text Link to item Cite

Comparison of Anterior Segment Optical Coherence Tomography Bleb Grading, Moorfields Bleb Grading System, and Intraocular Pressure After Trabeculectomy.

Journal Article J Glaucoma · May 2017 PURPOSE: To compare a novel anterior segment optical coherence tomography (AS-OCT) bleb grading system with a clinical bleb grading system and both with intraocular pressure (IOP) following trabeculectomy surgery. MATERIALS AND METHODS: A novel AS-OCT grad ... Full text Link to item Cite

Normal-Tension Glaucoma Masqueraders: Detection Using Optical Coherence Tomography.

Journal Article J Glaucoma · April 2017 PURPOSE: Optical coherence tomography (OCT) has become an important tool in the diagnosis and management of glaucoma; however, there can be overlap in the OCT findings between glaucoma and other diseases. We describe the clinical examination finings and in ... Full text Link to item Cite

Microcystic Macular Changes in Primary Open-angle Glaucoma.

Journal Article J Glaucoma · March 2016 PURPOSE: To describe microcystic macular changes in patients with moderate to advanced primary open-angle glaucoma. PATIENTS AND METHODS: Eleven eyes of 6 unrelated patients were retrospectively identified based on a disproportionately preserved macular th ... Full text Link to item Cite

Ocular Biometrics of Myopic Eyes With Narrow Angles.

Journal Article J Glaucoma · February 2016 PURPOSE: The purpose of this study was to compare the ocular biometrics between myopic patients with and without narrow angles. METHODS: Patients with a stable myopic refraction (myopia worse than -1.00 D spherical equivalent) were prospectively recruited. ... Full text Link to item Cite

A Comparative Study of Rebound Tonometry With Tonopen and Goldmann Applanation Tonometry Following Vitreoretinal Surgery.

Journal Article Am J Ophthalmol · January 2016 PURPOSE: To investigate agreement in intraocular pressure (IOP) measurements among Icare rebound tonometry, Tonopen tonometry, and Goldmann applanation tonometry following vitreoretinal surgery. DESIGN: Reliability analysis of tonometers. METHODS: Fifty-ey ... Full text Link to item Cite

Macular thickness analysis for glaucoma diagnosis and management.

Journal Article Taiwan J Ophthalmol · 2016 There is increasing literature regarding the role of macular imaging by optical coherence tomography (OCT) in glaucoma care. Spectral domain OCT (SD-OCT) has allowed for high resolution imaging of the total macula and macular segments. With the use of asym ... Full text Link to item Cite

Improved Surgical Success of Combined Glaucoma Tube Shunt and Retisert(®) Implantation in Uveitic Eyes: A Retrospective Study.

Journal Article Ophthalmol Ther · December 2015 INTRODUCTION: The purpose of this study was to determine whether the outcomes following placement of a fluocinolone acetonide implant (Retisert(®); Bausch & Lomb, Inc.) combined with an Ahmed™ glaucoma valve (New World Medical, Inc.) in eyes with uveitic g ... Full text Link to item Cite

En face imaging of retinal pathology using multicolor confocal scanning laser ophthalmoscopy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Retinal nerve fiber layer thickness measurements: uveitis, a major confounding factor.

Journal Article Ophthalmology · March 2015 OBJECTIVE: To evaluate optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) measurements in patients with active and quiescent uveitis with and without glaucoma and compare results to the published age-adjusted normative data. DESIGN: Compar ... Full text Link to item Cite

Paradoxical changes of retinal nerve fiber layer thickness in uveitic glaucoma.

Journal Article JAMA Ophthalmol · July 2014 IMPORTANCE: Measurement of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography can aid in the diagnosis and management of glaucoma. We observed a previously unreported phenomenon in eyes with uveitis-associated glaucoma in which p ... Full text Link to item Cite

Artifacts in spectral-domain optical coherence tomography measurements in glaucoma.

Journal Article JAMA Ophthalmol · April 1, 2014 IMPORTANCE Spectral-domain optical coherence tomography (SD-OCT) has an integral role in the diagnosis and treatment of glaucoma. Understanding the types of artifacts commonly seen in the imaging of patients being evaluated for glaucoma will help physician ... Full text Link to item Cite

Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain.

Journal Article Br J Ophthalmol · July 2013 BACKGROUND/AIMS: Spectral-domain (SD)- Optical Coherence Tomography (OCT) can track eye movements, has faster acquisition time and higher resolution than time-domain(TD)-OCT. The aim of the study was to assess the utility of SD-OCT in paediatric glaucoma a ... Full text Link to item Cite

Imaging of Ocular Angle Structures with Fourier Domain Optical Coherence Tomography.

Journal Article J Curr Glaucoma Pract · 2013 BACKGROUND: Imaging of the Schlemm's Canal is complicated by the small physiological size and the location several hundred microns beneath the sclera. Noninvasive imaging of Schlemm's canal and Trabecular Meshwork (TM) in vivo with Fourier Domain Optical C ... Full text Link to item Cite

Glaucoma masqueraders: Diagnosis by spectral domain optical coherence tomography.

Journal Article Saudi J Ophthalmol · October 2012 BACKGROUND: Advances in optic nerve and retinal imaging have dramatically changed the care of glaucoma patients, complementing the importance of the clinical exam of the optic nerve and automated perimetry in making the diagnosis of glaucoma. Computerized ... Full text Link to item Cite

Home assessment of diurnal intraocular pressure in healthy children using the Icare rebound tonometer.

Journal Article J AAPOS · February 2012 BACKGROUND: Although intraocular pressure (IOP) is known to vary with the circadian cycle in nonglaucomatous and glaucomatous eyes of adults, the clinical assessment of IOP often relies on periodic measurements obtained at office visits during daytime hour ... Full text Link to item Cite

Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios.

Journal Article Exp Eye Res · September 2011 Children with large optic nerve head cups often pose diagnostic difficulty due to concern over possible glaucoma. This study's purpose was to evaluate optical coherence tomography (OCT) measurement of the peripapillary retinal nerve fiber layer (RNFL) and ... Full text Link to item Cite

Home tonometry for management of pediatric glaucoma.

Journal Article Am J Ophthalmol · September 2011 PURPOSE: To use iCare rebound tonometry in the home setting for documentation of diurnal intraocular pressure (IOP) fluctuations in children. DESIGN: Nonrandomized, prospective clinical study. METHODS: Pediatric ophthalmology clinic patients were recruited ... Full text Link to item Cite

Novel software strategy for glaucoma diagnosis: asymmetry analysis of retinal thickness.

Journal Article Arch Ophthalmol · September 2011 Featured Publication The benefits of high-speed, detailed retinal thickness measurement by spectral-domain optical coherence tomography in glaucoma diagnosis have not been fully realized. We have modified the software protocols for such measurement and applied it for diagnosis ... Full text Link to item Cite

Clinical profiles of primary open angle glaucoma versus normal tension glaucoma patients: a pilot study.

Journal Article Curr Eye Res · May 2011 Featured Publication PURPOSE: To study the health profiles and behavioral differences between primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients. METHODS: Confidential mail survey of ICD-9 defined POAG (n = 277) and NTG (n = 116) patients was carried ... Full text Link to item Cite

Icare rebound tonometry in children with known and suspected glaucoma.

Journal Article J AAPOS · April 2011 BACKGROUND: Accurate intraocular pressure (IOP) measurement, important in managing pediatric glaucoma, often presents challenges. The Icare rebound tonometer shows promise for screening healthy children and has been reported comparable with Goldmann applan ... Full text Link to item Cite

In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene.

Journal Article Curr Eye Res · February 2011 PURPOSE: Long-term intraocular pressure reduction by glaucoma drainage devices (GDDs) is often limited by the fibrotic capsule that forms around them. Prior work demonstrates that modifying a GDD with a porous membrane promotes a vascularized and more perm ... Full text Open Access Link to item Cite

Evaluation of the ICare rebound tonometer as a home intraocular pressure monitoring device.

Journal Article J Glaucoma · February 2011 Featured Publication PURPOSE: (a) To investigate whether the ICare rebound tonometer can provide accurate measurements of intraocular pressure (IOP) in the hands of an inexperienced user compared with ICare measurements and Goldmann tonometry by a trained technician and (b) to ... Full text Link to item Cite

Differentiating glaucomatous from non-glaucomatous optic nerve cupping by optical coherence tomography.

Journal Article Open Neurol J · January 26, 2011 BACKGROUND: In clinical practice, the differentiation of glaucomatous from non-glaucomatous cupping can be difficult, even for experienced observers. The purpose of this study was to evaluate the role of optical coherence tomography (OCT) in differentiatin ... Full text Link to item Cite

Three-dimensional nature of retinal nerve fiber layer defects.

Journal Article J Glaucoma · December 2010 OBJECTIVE: To demonstrate the 3-dimensional nature of wedge-shaped retinal nerve fiber layer (RNFL) losses. To study the impact of training glaucoma fellows in this identification technique by evaluating their rate of RNFL loss detection on stereo disc pho ... Full text Link to item Cite

Integrating direct electronic collection of data from patients into the process of care for eye care professionals.

Journal Article AMIA Annu Symp Proc · November 13, 2010 Enabling collection of clinical data directly from patients has the potential to increase data accuracy and augment patient engagement in the care process. Most patient data entry systems have been created independent of electronic health records, and few ... Link to item Cite

A surface micromachined capacitive pressure sensor for intraocular pressure measurement

Conference Proceedings of 2010 IEEE/ASME International Conference on Mechatronic and Embedded Systems and Applications, MESA 2010 · October 8, 2010 In glaucoma patients, intraocular pressure (IOP) is a parameter that plays significant role in disease diagnosis and treatment. Continuous IOP measurements could help capture fluctuations in IOP that are found to be relevant to disease progression. In this ... Full text Cite

Selective laser trabeculoplasty reduces mean IOP and IOP variation in normal tension glaucoma patients.

Journal Article Clin Ophthalmol · August 9, 2010 Featured Publication PURPOSE: To evaluate the effect of selective laser trabeculoplasty (SLT) in normal tension glaucoma (NTG) patients. PATIENTS AND METHODS: A retrospective review was performed of NTG patients who had undergone SLT at the Duke University Eye Center between 1 ... Full text Link to item Cite

Methicillin-resistant Staphylococcus epidermidis isolation from the vitrectomy specimen four hours after initial treatment with vancomycin and ceftazidime

Journal Article Clinical Ophthalmology · April 30, 2010 A patient presented with acute-onset, postoperative endophthalmitis and visual acuity of light perception. Because of a time delay in arranging a pars plana vitrectomy (PPV), the patient was treated with a prompt vitreous tap for culture an injection of va ... Cite

Simultaneous bilateral angle closure glaucoma in a patient with giant cell arteritis.

Journal Article J Glaucoma · February 2010 PURPOSE: To report a case of bilateral angle closure in a patient with giant cell arteritis. DESIGN: Observational case report. METHODS: Review of clinical, photographic, and biopsy data of a 53-year-old patient who presented with bilateral angle closure g ... Full text Link to item Cite

Optical coherence tomography errors in glaucoma.

Journal Article J Glaucoma · 2010 PURPOSE: To demonstrate the types and prevalence of errors associated with the use of optical coherence tomography in a cross section of glaucoma patients. The association of different types of artifacts and certain coexisting ocular diagnoses was also eva ... Full text Link to item Cite

Correlation between optical coherence tomography and glaucomatous optic nerve head damage in children.

Journal Article Br J Ophthalmol · October 2009 AIM: To compare analysis of macular and nerve fibre layer thickness by optical coherence tomography (OCT) with optic nerve head (ONH) morphology based on stereophotography. DESIGN: Prospective observational case-control series. METHODS: Normal and glaucoma ... Full text Link to item Cite

Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve.

Journal Article Curr Eye Res · July 2009 PURPOSE: Long-term intraocular pressure control by glaucoma drainage implants is compromised by the formation of an avascular fibrous capsule that surrounds the glaucoma implant and increases aqueous outflow resistance. It is possible to alter this fibroti ... Full text Link to item Cite

Optical coherence tomography in the eyes of normal children.

Journal Article Arch Ophthalmol · January 2009 Featured Publication OBJECTIVE: To collect a normative database of macular thickness, retinal nerve fiber layer (RNFL) thicknesses, and optic nerve topography in the healthy eyes of children aged 3 to 17 years using optical coherence tomography (OCT) measurements. METHODS: Sca ... Full text Link to item Cite

Surgical management of hypotony owing to overfiltration in eyes receiving glaucoma drainage devices.

Journal Article J Glaucoma · 2009 PURPOSE: To assess rates of surgical revision of glaucoma drainage devices (GDDs) from hypotony owing to overfiltration and its management. DESIGN: Retrospective case series. METHODS: Demographic characteristics, type of GDD implanted, type of surgical rev ... Full text Link to item Cite

Effects of medications and surgery on intraocular pressure fluctuation.

Journal Article Surv Ophthalmol · November 2008 Intraocular pressure (IOP) varies dynamically throughout the circadian cycle. IOP elevations during the nocturnal period may be particularly important in the pathogenesis of glaucoma, although sleeping IOP cannot be measured at this time. Additionally, IOP ... Full text Link to item Cite

Detailed visualization of the anterior segment using fourier-domain optical coherence tomography.

Journal Article Arch Ophthalmol · June 2008 Featured Publication OBJECTIVE: To study details of the anterior chamber drainage angle using Fourier-domain optical coherence tomography in healthy subjects and patients with angle abnormalities. METHODS: A high-speed anterior segment optical coherence tomography prototype wa ... Full text Link to item Cite

Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography.

Journal Article Arch Ophthalmol · April 2008 We have demonstrated a novel Fourier-domain optical coherence tomography system and signal-processing algorithm for full-range, real-time, artifact-free quantitative imaging of the anterior chamber. Cross-sectional full-range images comprising 1024 x 800 p ... Full text Link to item Cite

New ways to measure intraocular pressure.

Journal Article Curr Opin Ophthalmol · March 2008 Featured Publication PURPOSE OF REVIEW: In the last 10 years, several new means to measure intraocular pressure have emerged. This review covers recent findings concerning four new technologies: the ocular response analyzer, dynamic contour tonometry, rebound tonometry and the ... Full text Link to item Cite

Intraocular pressure monitoring sensors

Journal Article IEEE Sensors Journal · January 1, 2008 Continuous measurement of intraocular pressure is important in the detection and treatment of glaucoma. While a point check of intraocular pressure in a doctor's office using indirect measurements such as the tonometer is helpful, it is inadequate to track ... Full text Cite

Computational mechanics of the sclera and optic nerve head (ONH): Effects of ONH size and pressure range

Conference 2008 Proceedings of the 3rd Frontiers in Biomedical Devices Conference and Exhibition · January 1, 2008 Computational modeling was performed to study how loss of compliance of the eye and abnormally high pressures result in changes in stresses and strains that may impact the optic nerve in diseases such as glaucoma. Hemispherical finite element models of the ... Full text Cite

Optical coherence tomography as a tool for monitoring pediatric pseudotumor cerebri.

Journal Article J AAPOS · December 2007 PURPOSE: To evaluate optical coherence tomography (OCT) measurement of peripapillary retinal nerve fiber layer (RNFL) and macular thickness in children with pseudotumor cerebri. METHODS: Prospective observational series of children with pseudotumor cerebri ... Full text Link to item Cite

The clinical utility of dynamic contour tonometry and ocular pulse amplitude.

Journal Article J Glaucoma · December 2007 PURPOSE: To determine if ocular pulse amplitude (OPA) as measured by dynamic contour tonometry (DCT) is related to severity of glaucoma, and if intraocular pressure (IOP) as measured by DCT is related to central corneal thickness (CCT). METHODS: Patients w ... Full text Link to item Cite

In response [3]

Other Journal of Glaucoma · March 1, 2007 Full text Cite

Thermal-sensitive liposomes

Chapter · January 1, 2006 Liposomes are microscopic lipid bubbles designed to entrap drugs. They have been used locally as well as systemically for targeting of drugs to specific organs or for prolonging drug effect. The encapsulation of drugs in liposomes has been shown to reduce ... Cite

High failure rate associated with 180 degrees selective laser trabeculoplasty.

Journal Article J Glaucoma · October 2005 PURPOSE: To determine the efficacy of selective laser trabeculoplasty (SLT) in a tertiary care referral center. PATIENTS AND METHODS: In this retrospective study of selective laser trabeculoplasty performed by five physicians, 94 eyes from 94 patients were ... Full text Link to item Cite

Diurnal intraocular pressure fluctuations

Conference Asian Journal of Ophthalmology · July 21, 2005 Cite

Macular and retinal nerve fiber layer analysis of normal and glaucomatous eyes in children using optical coherence tomography.

Journal Article Am J Ophthalmol · March 2005 PURPOSE: To evaluate macular and nerve fiber layer (NFL) thickness in normal and glaucomatous eyes of children 3 to 17 years old using optical coherence tomography (OCT-3). DESIGN: Observational cross-sectional study. METHODS: One hundred fifty-six eyes of ... Full text Link to item Cite

Retinal Thickness Analyzer

Chapter · January 1, 2005 Full text Cite

Outflow facility of a Glaucoma Valve enclosed in expanded polytetrafluoroethylene (ePTFE)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · January 1, 2005 Link to item Cite

Clinical comparison of the Proview eye pressure monitor with the Goldmann applanation tonometer and the Tonopen.

Journal Article Arch Ophthalmol · August 2004 OBJECTIVE: To compare intraocular pressure (IOP) values obtained by patients using the new Proview eye pressure monitor (Bausch & Lomb, Rochester, NY) with those measured with the Goldmann tonometer and the TonoPen (Mentor, Norwell, Mass). METHODS: Eighty- ... Full text Link to item Cite

A newer technique for glaucoma tube trimming.

Journal Article Arch Ophthalmol · September 2003 Long silicone glaucoma tubes within the anterior chamber are frequently detrimental to the corneal endothelium and other anterior chamber structures. Tube shortening often involves extensive and potentially complicated surgery that requires tube removal an ... Full text Link to item Cite

Increased periocular pigmentation with ocular hypotensive lipid use in African Americans.

Journal Article Am J Ophthalmol · May 2003 PURPOSE: To report increased eyelid pigmentation as an adverse side effect associated with topical ocular hypotensive lipids in African Americans. DESIGN: Interventional case series. METHODS: Two African-American patients with open-angle glaucoma are descr ... Full text Link to item Cite

Correlation among retinal thickness, optic disc, and visual field in glaucoma patients and suspects: a pilot study.

Journal Article J Glaucoma · April 2003 OBJECTIVE: To correlate losses of retinal thickness in the perifoveal area in glaucoma as measured by the Retinal Thickness Analyzer (Talia Technology Ltd, Israel) with optic nerve and visual field changes in glaucoma patients and suspects. METHODS: Observ ... Full text Link to item Cite

Early clinical experience with the ahmed glaucoma bi-plate

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2002 Link to item Cite

Relation between retinal thickening and clinically visible fundus pathologies in mild nonproliferative diabetic retinopathy.

Journal Article Ophthalmic Surg Lasers · 2002 BACKGROUND AND OBJECTIVE: To determine the association of retinal thickening (RT) with clinically observable retinal pathologies in eyes with mild nonproliferative diabetic retinopathy. PATIENTS AND METHODS: Using an objective quantitative imaging method ( ... Link to item Cite

Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma.

Journal Article J Glaucoma · April 2000 Featured Publication PURPOSE: To study the risk associated with diurnal intraocular pressure (IOP) variations in patients with open-angle glaucoma. PATIENTS AND METHODS: Sixty-four patients (105 eyes) from the practices of two glaucoma specialists successfully performed home t ... Full text Link to item Cite

Does primary intraocular lens implantation prevent "aphakic" glaucoma in children?

Journal Article J AAPOS · February 2000 Featured Publication PURPOSE: Open-angle glaucoma may develop after surgery for congenital or developmental cataract with an incidence ranging from 3% to 41%. The pathogenesis of "aphakic" (open-angle) glaucoma remains unknown. Despite numerous reported clinical series (>1000 ... Full text Link to item Cite

Letters to the Editor

Journal Article Journal of Glaucoma · January 1, 2000 Cite

Noninvasive mapping of the normal retinal thickness at the posterior pole.

Journal Article Ophthalmology · February 1999 OBJECTIVE: Objective and sensitive measurements of the retinal thickness at the posterior pole are useful to detect and delineate macular edema or retinal atrophy. The authors therefore developed an instrument, the Retinal Thickness Analyzer (RTA), to map ... Full text Link to item Cite

Optical cross-sectional imaging of the macula with the retinal thickness analyzer in X-linked retinoschisis.

Journal Article Arch Ophthalmol · August 1998 OBJECTIVE: To assess the morphologic characteristics of the foveal abnormality in juvenile X-linked retinoschisis using the scanning retinal thickness analyzer (RTA). This characteristic foveal abnormality is present in 83% to 100% of patients with X-linke ... Full text Link to item Cite

Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping. A pilot study.

Journal Article Ophthalmology · February 1998 OBJECTIVE: The posterior pole ganglion cell bodies form a substantial fraction of the retinal thickness, prompting the authors to study the feasibility of detecting, by scanning retinal thickness analysis, retinal changes at the posterior pole due to glauc ... Full text Link to item Cite

Serial optical sectioning of macular holes at different stages of development.

Journal Article Ophthalmology · January 1998 OBJECTIVE: This study aimed to examine the characteristics of intraretinal changes associated with macular holes and epiretinal membranes by scanning retinal thickness analysis. STUDY DESIGN: The study design was a nonconsecutive case series. PATIENTS: Fif ... Full text Link to item Cite

Feasibility of laser-targeted photoocclusion of the choriocapillary layer in rats.

Journal Article Invest Ophthalmol Vis Sci · December 1997 PURPOSE: A new method, laser-targeted photoocclusion, was developed to occlude choroidal neovascularization while minimizing damage to the overlying retina. The ability to occlude normal choriocapillary layer in rats was evaluated as a first test of the fe ... Link to item Cite

High resolution map of the normal retinal thickness at the posterior pole

Conference Investigative Ophthalmology and Visual Science · December 1, 1997 Purpose. Objective and sensitive measurements of the retinal thickness at the posterior pole are useful to detect and delineate macular edema or retinal atrophy. We have developed a method of rapid mapping of the retinal thickness and applied it to the stu ... Cite

Foveal optical sectioning with the retinal thickness analyzer in patients with juvenile x-linked retinoschisis

Conference Investigative Ophthalmology and Visual Science · December 1, 1997 Purpose. The nearly pathognomonic foveal abnormality present in 98 to !00% of patients with juvenile X-linked retinoschisis (XLRS) has not been demonstrated histopathologically. The retinal thickness analyzer (RTA) is a non-contact imaging technique that g ... Cite

Edematous retinal thickening does not correlate with clinically visible fundus pathologies in diabetic patients

Conference Investigative Ophthalmology and Visual Science · December 1, 1997 Purpose. The availability of a sensitive method to measure the retinal thickness allowed us to investigate the relationship between thickening and the underlying vascular pathology observed clinically. Methods- The measurements were performed on a non-scan ... Cite

Application of rapid scanning retinal thickness analysis in retinal diseases.

Journal Article Ophthalmology · July 1997 PURPOSE: The authors have further developed their method of retinal thickness analysis to rapidly generate multiple optical cross sections of the retina and provide thickness maps at the posterior pole. The potential use of this method was evaluated in a n ... Full text Link to item Cite

A new method for rapid mapping of the retinal thickness at the posterior pole.

Journal Article Invest Ophthalmol Vis Sci · September 1996 PURPOSE: An objective, quantitative, and sensitive method to map retinal thickness is needed to diagnose more effectively the conditions causing alterations in thickness, such as macular edema and neuroretinal atrophy. METHODS: An instrument, the retinal t ... Link to item Cite

Selective visualization of choroidal neovascular membranes.

Journal Article Invest Ophthalmol Vis Sci · July 1996 PURPOSE: Laser-targeted angiography has unique advantages over conventional angiography of the fundus. Its efficacy in visualizing choroidal neovascular membranes was tested in a rat model and compared to that of fluorescein angiography. METHOD: Laser-targ ... Link to item Cite

Detailed mapping of the normal posterior pole retinal thickness by the scanning retinal thickness analyzer

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: We have previously reported on the measurement of the retinal thickness at selected locations in the posterior pole with the aid of our method, the Retinal Thickness Analyzer (RTA). However, there is a clinical need to assess the area as well as t ... Cite

Sensitive, noninvasive and objective detection of glaucomatous damage based on the assessment of ganglion cell atrophy with the scanning retinal thickness analyzer

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Introduction: We have developed a method, the scanning Retinal Thickness Analyzer (RTA), to scan rapidly the posterior pole and generate a detailed map of the retinal thickness. The scanning RTA was applied in a pilot group of glaucoma patients to assess w ... Cite

Visualization of macular pathologies by rapid scanning retinal thickness analysis

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: In vivo cross section imaging of the retina may be useful for identifying, monitoring and quantitatively assessing macular diseases. Our method, the scanning Retinal Thickness Analyzer (RTA), provides rapid, multiple and non-contact cross sectiona ... Cite

Feasibility of selective occlusion of choriocapillaries by laser targeted photo-occlusion

Other Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: Photodynamic therapy (PDT) is being considered as a method to non-thermally occlude choroidal neovascular membranes. However, it may not preserve integrity of the RPE. We developed a new method, laser targeted photo-occlusion, which potentially ca ... Cite

Effects on the RPE following choriocapillaris occlusion induced by laser targeted photo-occlusion and conventional photodynamic therapy

Conference Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: Photodynamic therapy (PDT) is being evaluated as a method to non-thermally occlude choroidal neovascular membranes (CNVM), but it may not preserve RPE integrity. Our method, laser targeted photo-occlusion, might occlude CNVM selectively, while pos ... Cite

Management of bleb leaks after glaucoma filtering surgery. Use of autologous fibrin tissue glue as an alternative.

Journal Article Ophthalmology · February 1996 PURPOSE: To study the nature of bleb leaks after contemporary glaucoma filtering surgery as well as to evaluate various treatment modalities, including autologous fibrin tissue glue (AFTG) prepared in a modified manner. METHODS: Patients who presented to a ... Full text Link to item Cite

Noninvasive visualization of blood flow in the choriocapillaris of the rat.

Journal Article Invest Ophthalmol Vis Sci · February 1996 PURPOSE: The rat has been used to generate models of various eye diseases. However, methods to study the choriocapillaris noninvasively have been inadequate in this species. Laser-targeted angiography was applied to generate local, repetitive angiograms of ... Link to item Cite

Feasibility of laser targeted photo-occlusion of ocular vessels.

Journal Article Br J Ophthalmol · August 1995 AIMS/BACKGROUND: Neovascularisation occurs in many major ocular diseases such as diabetes, age-related macular degeneration, and sickle cell disease. Laser photocoagulation is typically used to obliterate the vessels but it also causes severe damage to adj ... Full text Link to item Cite

Glaucoma after congenital cataract surgery.

Journal Article Ophthalmology · June 1995 OBJECTIVES: To study eyes that manifested glaucoma after congenital cataract surgery and to identify factors that might lead to better diagnosis and treatment of such glaucoma. DESIGN: A retrospective review of patients treated for glaucoma that developed ... Full text Link to item Cite

Local response of the primate retinal microcirculation to increased metabolic demand induced by flicker.

Journal Article Invest Ophthalmol Vis Sci · June 1995 PURPOSE: To study the response of the macular circulation to a local increase in metabolic demand created by a flickering source of illumination. METHODS: Laser-targeted angiography (release of a fluorescent dye from heat-sensitive liposomes using a laser ... Link to item Cite

Systemic toxicology and laser safety of laser targeted angiography with heat sensitive liposomes.

Journal Article J Ocul Pharmacol Ther · 1995 Angiography is currently limited by its lack of local and tissue specificity. The dye rapidly fills both the retinal and choroidal vessels and leaks out of the vessels thus hampering visualization of small vascular beds such as occult choroidal neovascular ... Full text Link to item Cite

Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty.

Journal Article Indian J Ophthalmol · September 1994 A new free radical scavenger, U74006F (Upjohn Company, Kalamazoo, MI, USA) was studied to determine if it would have a beneficial effect on preventing intraocular pressure (IOP) spikes and reducing blood-aqueous barrier (BAB) breakdown in rabbits after arg ... Link to item Cite

Noninvasive visualization of the choriocapillaris and its dynamic filling.

Journal Article Invest Ophthalmol Vis Sci · September 1994 PURPOSE: The choroidal microvasculature and its circulation are inadequately assessed by presently available techniques. Laser-targeted delivery was applied to generate local, repetitive angiograms of the choriocapillaris in primates. METHODS: Carboxyfluor ... Link to item Cite

THE VARIABILITY IN DIURNAL INTRAOCULAR-PRESSURE IS A RISK FACTOR FOR GLAUCOMATOUS PROGRESSION

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1994 Link to item Cite

EFFECT OF U74006F IN RABBIT EYES AFTER ARGON-LASER TRABECULOPLASTY

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1993 Link to item Cite

WAKING IOP SPIKES

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1993 Link to item Cite

Benign orbital neurilemmoma (a case report).

Journal Article J Postgrad Med · April 1991 Link to item Cite

MULTICOLOR IMAGING OF INNER RETINAL ALTERATIONS AFTER INTERNAL LIMITING MEMBRANE PEELING.

Journal Article Retin Cases Brief Rep PURPOSE: To characterize the appearance of inner retinal alterations after internal limiting membrane (ILM) peeling using multicolor confocal scanning laser ophthalmoscopy (cSLO). METHODS: Retrospective review of two eyes that underwent pars plana vitrecto ... Full text Link to item Cite