Scholars@Duke
Brian Sullivan

Brian Sullivan

Assistant Professor of Medicine
Medicine, Gastroenterology

Selected Publications

Diagnostic Performance of Stool-based Testing for Colorectal Lesions Among Average-risk Individuals: A Real-world Evidence Study.

Journal Article J Clin Gastroenterol · April 1, 2025 OBJECTIVE: We assessed the real-world performance of stool-based tests (SBTs) for colorectal cancer screening. MATERIALS AND METHODS: Retrospective review of average-risk individuals with positive SBT for advanced neoplasia (adenocarcinoma, advanced adenom ... Full text Link to item Cite

Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans.

Journal Article Cancer Epidemiol Biomarkers Prev · November 1, 2024 BACKGROUND: Risk for colorectal cancer may accumulate through multiple environmental factors. Understanding their effects, along with genetics, age, and family history, could allow improvements in clinical decisions for screening protocols. We aimed to ext ... Full text Link to item Cite

Supplementary Table S2 from Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans

Other · November 1, 2024 <p>Supplementary Table S2 shows the regression beta estimates and p-values for each e-Score risk factor for two training samples: 1) the Recalibrated MVP Male Training Sample, and 2) the GECCO Male Training Sample previously published by Jeon ... Full text Cite

Supplementary Table S3 from Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans

Other · November 1, 2024 <p>Supplementary Table S3 shows model fit statistics for five different sets if nested models calculated in this study: 1) Full Cohort; 2) Over 50 years old participants only; 3) Black race participants only; 4) Those who had at least one ide ... Full text Cite

Supplement S1 from Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans

Other · November 1, 2024 <p>Supplement S1: This document lists acknowledgements for the VA Million Veteran Program Core used in publications as of March 2024</p> ... Full text Cite

Data from Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans

Other · November 1, 2024 <div>AbstractBackground:<p>Risk for colorectal cancer may accumulate through multiple environmental factors. Understanding their effects, along with genetics, age, and family history, could allow improvements in clinical decisions for s ... Full text Cite

Supplementary Table S1 from Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans

Other · November 1, 2024 <p>Supplementary Table S1 shows demographic and lifestyle characteristics for the total sample for the female participants of the Million Veteran Program with complete lifestyle data and by colorectal cancer (CRC) cases versus those without C ... Full text Cite

Development and Validation of an Electronic Adverse Event Model for Patient Safety Surveillance in Interventional Radiology.

Journal Article Journal of the American College of Radiology : JACR · May 2024 BackgroundComprehensive adverse event (AE) surveillance programs in interventional radiology (IR) are rare. Our aim was to develop and validate a retrospective electronic surveillance model to identify outpatient IR procedures that are likely to h ... Full text Cite

Colon Polyp Surveillance: Separating the Wheat From the Chaff.

Journal Article Gastroenterology · May 2024 One goal of colorectal cancer (CRC) screening is to prevent CRC incidence by removing precancerous colonic polyps, which are detected in up to 50% of screening examinations. Yet, the lifetime risk of CRC is 3.9%-4.3%, so it is clear that most of these indi ... Full text Link to item Cite

Colorectal cancer screening uptake and adherence by modality at a large tertiary care center in the United States: a retrospective analysis.

Journal Article Curr Med Res Opin · March 2024 OBJECTIVE: Real-world data is crucial to inform existing opportunistic colorectal cancer (CRC) prevention programs. This study aimed to assess CRC screening adherence and utilization of various screening modalities within a Primary Care network over a thre ... Full text Link to item Cite

Colorectal Cancer Polygenic Risk Score Is Associated With Screening Colonoscopy Findings but Not Follow-Up Outcomes.

Journal Article Gastro Hep Adv · 2024 BACKGROUND AND AIMS: Colorectal cancer (CRC) polygenic risk scores (PRS) may help personalize CRC prevention strategies. We investigated whether an existing PRS was associated with advanced neoplasia (AN) in a population undergoing screening and follow-up ... Full text Link to item Cite

Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial.

Journal Article JAMA Netw Open · July 3, 2023 IMPORTANCE: The Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) randomized clinical trial sought to recruit 50 000 adults into a study comparing colorectal cancer (CRC) mortality outcomes after randomizat ... Full text Link to item Cite

Quality Improvement Training for Gastroenterology and Hepatology Fellowship: More Than Just a GME Requirement.

Journal Article Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · June 2023 Full text Cite

Arteriovenous Graft Failure in the Veterans Health Administration: Outcome Disparities Associated with Race.

Journal Article Radiology · May 2023 Background Vascular access for ongoing hemodialysis often fails, frequently requiring repeated procedures to maintain vascular patency. While research has shown racial discrepancies in multiple aspects of renal failure treatment, there is poor understandin ... Full text Link to item Cite

Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder.

Journal Article Neurogastroenterol Motil · May 2023 BACKGROUND: Gulf War Illness (GWI) is a chronic, multi-symptom disorder affecting 25%-32% of Gulf War veterans. Veterans with GWI disproportionately suffer from gastrointestinal (GI) disorders. Given the increasing evidence supporting a gut-brain axis, we ... Full text Link to item Cite

Development of a Periprocedure Trigger for Outpatient Interventional Radiology Procedures in the Veterans Health Administration.

Journal Article J Patient Saf · April 1, 2023 OBJECTIVES: Interventional radiology (IR) is the newest medical specialty. However, it lacks robust quality assurance metrics, including adverse event (AE) surveillance tools. Considering the high frequency of outpatient care provided by IR, automated elec ... Full text Link to item Cite

Improving documentation of anticoagulation and antiplatelet recommendations after outpatientendoscopy.

Journal Article BMJ Open Qual · December 2022 Clear documentation of instructions for resuming anticoagulant and antiplatelet (AC/AP) medications after gastrointestinal endoscopy is essential for high-quality postprocedure care. Yet, these recommendations are frequently absent, which may impact patien ... Full text Link to item Cite

Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis.

Journal Article Am J Gastroenterol · November 1, 2022 INTRODUCTION: Germline variants in CDH1 are associated with elevated risks of diffuse gastric cancer and lobular breast cancer. It is uncertain whether there is an increased risk of colorectal neoplasia. METHODS: This was a retrospective analysis of colono ... Full text Link to item Cite

Response.

Journal Article Gastrointest Endosc · November 2022 Full text Link to item Cite

Longitudinal assessment of colonoscopy adverse events in the prospective Cooperative Studies Program no. 380 colorectal cancer screening and surveillance cohort.

Journal Article Gastrointest Endosc · September 2022 BACKGROUND AND AIMS: Data are limited regarding colonoscopy risk during long-term, programmatic colorectal cancer screening and follow-up. We aimed to describe adverse events during follow-up in a colonoscopy screening program after the baseline examinatio ... Full text Link to item Cite

Ten or More Cumulative Lifetime Adenomas Are Associated with Increased Risk for Advanced Neoplasia and Colorectal Cancer.

Journal Article Dig Dis Sci · June 2022 BACKGROUND: Colorectal cancer (CRC) screening guidelines recommend frequent colonoscopies and consideration of genetic testing in individuals with ≥10 cumulative adenomas. However, it is unclear how these guidelines apply to routine practice. AIMS: We esti ... Full text Link to item Cite

Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer.

Journal Article Gastrointest Endosc Clin N Am · April 2022 Colorectal cancer is the second leading cause of cancer-associated mortality, with a lifetime risk of approximately 4% to 5%. Colorectal cancer develops from the sequential acquisition of defined genetic mutations in the colonic epithelium. Tumorigenesis f ... Full text Link to item Cite

Screening Colonoscopy Findings Are Associated With Noncolorectal Cancer Mortality.

Journal Article Clin Transl Gastroenterol · April 1, 2022 INTRODUCTION: Controversy exists regarding the impact of various risk factors on noncolorectal cancer (CRC) mortality in healthy screening populations. We examined the impact of known CRC risk factors, including baseline colonoscopy findings, on non-CRC mo ... Full text Link to item Cite

Endoscopic Management and Surgical Considerations for Familial Adenomatous Polyposis.

Journal Article Gastrointest Endosc Clin N Am · January 2022 Familial adenomatous polyposis (FAP) is the development of many adenomatous colorectal polyps. Colonoscopy is recommended to start at age 10 to 12 years at intervals of 1 to 2 years. Colectomy is clearly indicated for malignancy or significant colorectal s ... Full text Link to item Cite

Characterizing chronological accumulation of comorbidities in healthy veterans: a computational approach.

Journal Article Sci Rep · April 14, 2021 Understanding patient accumulation of comorbidities can facilitate healthcare strategy and personalized preventative care. We applied a directed network graph to electronic health record (EHR) data and characterized comorbidities in a cohort of healthy vet ... Full text Open Access Link to item Cite

Esophageal contractile segment impedance from high-resolution impedance manometry correlates with mean nocturnal baseline impedance and acid exposure time from 24-hour pH-impedance monitoring.

Journal Article Dis Esophagus · December 7, 2020 Esophageal baseline impedance (BI) acquired during esophageal contraction (contractile segment impedance [CSI]) is proposed to improve BI accuracy in gastroesophageal reflux disease (GERD). We evaluated associations between CSI and conventional and novel G ... Full text Link to item Cite

Genetic Colorectal Cancer and Adenoma Risk Variants Are Associated with Increasing Cumulative Adenoma Counts.

Conference Cancer Epidemiol Biomarkers Prev · November 2020 BACKGROUND: The genetic basis for most individuals with high cumulative lifetime colonic adenomas is unknown. We investigated associations between known colorectal cancer-risk single-nucleotide polymorphisms (SNP) and increasing cumulative adenoma counts. ... Full text Link to item Cite

Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring.

Journal Article J Neurogastroenterol Motil · September 30, 2020 BACKGROUND/AIMS: Esophageal baseline impedance (BI) can be extracted from pH-impedance tracings as mean nocturnal baseline impedance (MNBI), and from high-resolution impedance manometry (HRIM), but it is unknown if values are similar between acquisition me ... Full text Link to item Cite

High-Risk Adenomas at Screening Colonoscopy Remain Predictive of Future High-Risk Adenomas Despite an Intervening Negative Colonoscopy.

Journal Article Am J Gastroenterol · August 2020 INTRODUCTION: Limited data inform the current postpolypectomy surveillance guidelines, which suggest a shortened interval to third colonoscopy after a negative second examination if high-risk adenomas (HRA) were present on the initial screening colonoscopy ... Full text Link to item Cite

Standardizing inpatient colonoscopy preparations improves quality and provider satisfaction.

Journal Article Int J Health Care Qual Assur · March 9, 2020 PURPOSE: Inpatient colonoscopy bowel preparation quality is frequently suboptimal. This quality improvement (QI) intervention is focused on regimenting this process to impact important outcomes. DESIGN/METHODOLOGY/APPROACH: Define, Measure, Analyze, Improv ... Full text Open Access Link to item Cite

Baseline Colonoscopy Findings Associated With 10-Year Outcomes in a Screening Cohort Undergoing Colonoscopy Surveillance.

Journal Article Gastroenterology · March 2020 BACKGROUND & AIMS: Few studies have evaluated long-term outcomes of ongoing colonoscopic screening and surveillance in a screening population. We aimed to determine the 10-year risk for advanced neoplasia (defined as adenomas ≥10mm, adenomas with villous h ... Full text Link to item Cite

Advanced neoplasia in Veterans at screening colonoscopy using the National Cancer Institute Risk Assessment Tool.

Journal Article BMC Cancer · November 12, 2019 BACKGROUND: Adapting screening strategy to colorectal cancer (CRC) risk may improve efficiency for all stakeholders however limited tools for such risk stratification exist. Colorectal cancers usually evolve from advanced neoplasms that are present for yea ... Full text Link to item Cite

Lymphogranuloma venereum (LGV) proctocolitis mimicking rectal lymphoma.

Journal Article Radiol Case Rep · December 2018 Lymphogranuloma venereum is a sexually transmitted infection caused by serotypes L1-3 of Chlamydia trachomatis and may present as hemorrhagic proctocolitis. The diagnosis of an active infection is difficult to establish, as confirmatory testing can be unre ... Full text Link to item Cite

An evaluation of physician predictions of discharge on a general medicine service.

Journal Article J Hosp Med · December 2015 The goal of this study was to evaluate general medicine physicians' ability to predict hospital discharge. We prospectively asked study subjects to predict whether each patient under their care would be discharged on the next day, on the same day, or neith ... Full text Open Access Link to item Cite