Scholars@Duke
Carlene D Moore

Carlene D Moore

Assistant Professor in Neurology
Neurology, Translational Brain Sciences
Bryan Res Bldg Room 249, Box 2900, Durham, NC 27710

Selected Publications

TRPV4-Mast Cell Interactions in Neurogenic Inflammation and Chronic Diseases: A Narrative Review.

Journal Article Int J Mol Sci · March 21, 2026 Transient receptor potential vanilloid 4 (TRPV4) is a polymodal cation channel that is widely expressed in sensory neurons, immune cells, and structural tissues, where it integrates mechanical, osmotic, and chemical stimuli to regulate both physiological r ... Full text Link to item Cite

Triptan Initiation and Cerebrovascular Events in Patients With Migraine: A Nationwide Cohort Study.

Journal Article J Am Heart Assoc · February 17, 2026 BACKGROUND: Triptan medications are proposed as an association of cerebral ischemic stroke in patients with migraine, but population-based data on this are lacking. METHODS: A retrospective, observational, cohort study was performed using computerized clai ... Full text Link to item Cite

Calcitonin Gene-Related Peptide Inhibitors and Cardiovascular Events in Patients With Migraine: A Retrospective, Observational Cohort Study.

Journal Article Neurology · February 10, 2026 BACKGROUND AND OBJECTIVES: Calcitonin gene-related peptide (CGRP) inhibitors have entered widespread use in the United States for treatment of migraine, but data on their cardiovascular risk profile are lacking. The objective of this study was to determine ... Full text Link to item Cite

Abstract 4363087: Calcitonin Gene-Related Peptide (CGRP) Inhibitor Use Is Associated With Increased Cardiovascular Event Risk in Patients with Migraine: A Nationwide Study

Conference Circulation · November 4, 2025 Introduction: Calcitonin gene-related peptide (CGRP) inhibitors are increasingly used in the United States (US) for the prevention and treatment of migraine, but population-based data ... Full text Cite

IHC 2025 late-breaking abstracts.

Journal Article Cephalalgia · November 2025 Full text Link to item Cite

OnabotulinumtoxinA effects on trigeminal nociceptors.

Journal Article Cephalalgia · February 2023 BACKGROUND: OnabotulinumtoxinA (onabotA) is approved globally for prevention of chronic migraine; however, the classical mechanism of action of onabotA in motor and autonomic neurons cannot fully explain the effectiveness of onabotulinumtoxinA in this sens ... Full text Link to item Cite

The role of TRPV4 channels in cutaneous epithelia.

Journal Article Curr Top Membr · 2022 Transient receptor potential vanilloid 4 (TRPV4) channels are multi-modally activated cation permeable channels that are expressed most organ tissues including the skin. TRPV4 is highly expressed in the skin and functions in skin resident cells such as epi ... Full text Link to item Cite

Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.

Journal Article Gastroenterology · July 2021 BACKGROUND & AIMS: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. METHODS: ... Full text Link to item Cite

Regulation of Pain and Itch by TRP Channels.

Journal Article Neurosci Bull · February 2018 Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important experimental evidence involving some TRP ion channels as molecular sensors of chemical, thermal, and mechani ... Full text Link to item Cite

TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.

Journal Article J Invest Dermatol · April 2017 Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 ... Full text Link to item Cite

The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.

Journal Article Front Cell Neurosci · 2016 AGAP1 is an Arf1 GTPase activating protein that interacts with the vesicle-associated protein complexes adaptor protein 3 (AP-3) and Biogenesis of Lysosome Related Organelles Complex-1 (BLOC-1). Overexpression of AGAP1 in non-neuronal cells results in an a ... Full text Link to item Cite

TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.

Journal Article Pain · December 2014 Detection of external irritants by head nociceptor neurons has deep evolutionary roots. Irritant-induced aversive behavior is a popular pain model in laboratory animals. It is used widely in the formalin model, where formaldehyde is injected into the roden ... Full text Open Access Link to item Cite

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.

Journal Article Proc Natl Acad Sci U S A · August 20, 2013 At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin cells and known to function in se ... Full text Open Access Link to item Cite

Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.

Journal Article Pain · August 2013 Temporomandibular joint disorder (TMJD) is known for its mastication-associated pain. TMJD is medically relevant because of its prevalence, severity, chronicity, the therapy-refractoriness of its pain, and its largely elusive pathogenesis. Against this bac ... Full text Open Access Link to item Cite

The neuronal Arf GAP centaurin alpha1 modulates dendritic differentiation.

Journal Article J Cell Sci · August 1, 2007 Centaurin alpha1 is an Arf GTPase-activating protein (GAP) that is highly expressed in the nervous system. In the current study, we show that endogenous centaurin alpha1 protein is localized in the synaptosome fraction, with peak expression in early postna ... Full text Link to item Cite

Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14.

Journal Article J Neurosci · November 1, 2006 The ataxia mutation (axJ) is a recessive neurological mutation that results in reduced growth, ataxia, and hindlimb muscle wasting in mice. The axJ gene encodes ubiquitin-specific protease 14 (Usp14), a deubiquitinating enzyme (DUB) that associates with th ... Full text Link to item Cite

The arf6 GAP centaurin alpha-1 is a neuronal actin-binding protein which also functions via GAP-independent activity to regulate the actin cytoskeleton.

Journal Article Eur J Cell Biol · October 2004 Centaurin alpha-1 is a high-affinity PtdIns(3,4,5)P3-binding protein enriched in brain. Sequence analysis indicates centaurin alpha-1 contains two pleckstrin homology domains, ankyrin repeats and an Arf GAP homology domain, placing it in the AZAP family of ... Full text Link to item Cite

Osmomechanical-Sensitive TRPV Channels in Mammals

Journal Article CRC Press/Taylor & Francis Full text Cite