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Carlene D Moore

Assistant Professor in Neurology
Neurology, Headache and Pain
Bryan Res Bldg Room 249, Box 2900, Durham, NC 27710

Selected Publications

OnabotulinumtoxinA effects on trigeminal nociceptors.

Journal Article Cephalalgia · February 2023 BACKGROUND: OnabotulinumtoxinA (onabotA) is approved globally for prevention of chronic migraine; however, the classical mechanism of action of onabotA in motor and autonomic neurons cannot fully explain the effectiveness of onabotulinumtoxinA in this sens ... Full text Link to item Cite

The role of TRPV4 channels in cutaneous epithelia.

Journal Article Curr Top Membr · 2022 Transient receptor potential vanilloid 4 (TRPV4) channels are multi-modally activated cation permeable channels that are expressed most organ tissues including the skin. TRPV4 is highly expressed in the skin and functions in skin resident cells such as epi ... Full text Link to item Cite

Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.

Journal Article Gastroenterology · July 2021 BACKGROUND & AIMS: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. METHODS: ... Full text Link to item Cite

Regulation of Pain and Itch by TRP Channels.

Journal Article Neurosci Bull · February 2018 Nociception is an important physiological process that detects harmful signals and results in pain perception. In this review, we discuss important experimental evidence involving some TRP ion channels as molecular sensors of chemical, thermal, and mechani ... Full text Link to item Cite

TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.

Journal Article J Invest Dermatol · April 2017 Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 ... Full text Link to item Cite

TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.

Journal Article Pain · December 2014 Detection of external irritants by head nociceptor neurons has deep evolutionary roots. Irritant-induced aversive behavior is a popular pain model in laboratory animals. It is used widely in the formalin model, where formaldehyde is injected into the roden ... Full text Open Access Link to item Cite

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.

Journal Article Proc Natl Acad Sci U S A · August 20, 2013 At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin cells and known to function in se ... Full text Open Access Link to item Cite

Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.

Journal Article Pain · August 2013 Temporomandibular joint disorder (TMJD) is known for its mastication-associated pain. TMJD is medically relevant because of its prevalence, severity, chronicity, the therapy-refractoriness of its pain, and its largely elusive pathogenesis. Against this bac ... Full text Open Access Link to item Cite

The neuronal Arf GAP centaurin α1 modulates dendritic differentiation

Journal Article Journal of Cell Science · August 1, 2007 Centaurin α1 is an Arf GTPase-activating protein (GAP) that is highly expressed in the nervous system. In the current study, we show that endogenous centaurin α1 protein is localized in the synaptosome fraction, with peak expression in early postna ... Full text Cite

Transgenic Rescue ofataxiaMice with Neuronal-Specific Expression of Ubiquitin-Specific Protease 14

Journal Article The Journal of Neuroscience · November 1, 2006 Theataxiamutation (axJ) is a recessive neurological mutation that results in reduced growth, ataxia, and hindlimb muscle wasting in mice. TheaxJ Full text Cite

Osmomechanical-Sensitive TRPV Channels in Mammals

Journal Article CRC Press/Taylor & Francis Full text Cite