Scholars@Duke
Carol Anne Hahn

Carol Anne Hahn

Professor Emeritus of Radiation Oncology
Radiation Oncology
Box 3085 Med Ctr, Durham, NC 27710
3404 Wake Forest Road, Mob 7, LL, Raleigh, NC 27609
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Selected Publications

A Multidisciplinary Consensus Recommendation on a Synoptic Radiation Treatment Summary: A Commission on Cancer Workgroup Report.

Journal Article Pract Radiat Oncol · 2020 PURPOSE: The radiation treatment summary provides a clinical and technical overview of a patient's full course of radiation therapy. Despite its importance to multiple stakeholders, there is no widely followed radiation treatment summary template. METHODS ... Full text Link to item Cite

Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline.

Journal Article Pract Radiat Oncol · 2018 INTRODUCTION: The purpose of this guideline is to offer recommendations on fractionation for whole breast irradiation (WBI) with or without a tumor bed boost and guidance on treatment planning and delivery. METHODS AND MATERIALS: The American Society for R ... Full text Link to item Cite

Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline.

Journal Article Pract Radiat Oncol · 2017 PURPOSE: The purpose is to provide an update the Bone Metastases Guideline published in 2011 based on evidence complemented by expert opinion. The update will discuss new high-quality literature for the 8 key questions from the original guideline and impli ... Full text Link to item Cite

“Choosing Wisely”: The American Society for Radiation Oncology’s Top 5 List

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Choosing wisely: the American Society for Radiation Oncology's top 5 list.

Journal Article Pract Radiat Oncol · 2014 PURPOSE: To highlight 5 interventions that patients should question, as part of the Choosing Wisely campaign. This initiative, led by the American Board of Internal Medicine Foundation, fosters conversations between physicians and patients about treatments ... Full text Link to item Cite

Adjuvant and salvage radiotherapy after prostatectomy: AUA/ASTRO Guideline.

Journal Article J Urol · August 2013 PURPOSE: The purpose of this guideline is to provide a clinical framework for the use of radiotherapy after radical prostatectomy as adjuvant or salvage therapy. MATERIALS AND METHODS: A systematic literature review using the PubMed®, Embase, and Cochrane ... Full text Link to item Cite

Adjuvant and salvage radiation therapy after prostatectomy: American Society for Radiation Oncology/American Urological Association guidelines.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2013 PURPOSE: The purpose of this guideline was to provide a clinical framework for the use of radiation therapy after radical prostatectomy as adjuvant or salvage therapy. METHODS AND MATERIALS: A systematic literature review using PubMed, Embase, and Cochrane ... Full text Link to item Cite

International practice survey on the management of brain metastases: Third International Consensus Workshop on Palliative Radiotherapy and Symptom Control.

Journal Article Clin Oncol (R Coll Radiol) · August 2012 AIM: To evaluate international patterns of practice for the management of metastatic disease to the brain. MATERIALS AND METHODS: An online international practice survey was conducted from April to June 2010. Most of the survey questions were based on comm ... Full text Link to item Cite

An international survey on liver metastases radiotherapy.

Journal Article Acta Oncol · May 2012 BACKGROUND: An international survey of radiation therapy (RT) of liver metastases was undertaken by the Liver Cancer Workgroup of the Third International Consensus on Metastases Workshop at the 2010 American Society for Radiation Oncology (ASTRO) meeting. ... Full text Link to item Cite

International practice survey on palliative lung radiotherapy: third international consensus workshop on palliative radiotherapy and symptom control.

Journal Article Clin Lung Cancer · May 2012 BACKGROUND: The purpose of this work was to disseminate international practice survey results created in conjunction with the Third International Lung Cancer Consensus Workshop. PATIENTS AND METHODS: In conjunction with the American Society for Radiation O ... Full text Link to item Cite

Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: To update the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases by surveying international experts regarding previous uncertainties within the 2002 consensus, changes that may be necessary b ... Full text Link to item Cite

Consensus statement on palliative lung radiotherapy: third international consensus workshop on palliative radiotherapy and symptom control.

Journal Article Clin Lung Cancer · January 2012 The purpose of this work is to disseminate a consensus statement on palliative radiotherapy (RT) of lung cancer created in conjunction with the Third International Lung Cancer Consensus Workshop. The palliative lung RT workshop committee agreed on 5 questi ... Full text Link to item Cite

Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline.

Journal Article Pract Radiat Oncol · 2012 PURPOSE: To systematically review the evidence for the radiotherapeutic and surgical management of patients newly diagnosed with intraparenchymal brain metastases. METHODS AND MATERIALS: Key clinical questions to be addressed in this evidence-based Guideli ... Full text Link to item Cite

Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2011 Featured Publication PURPOSE: In patients with early-stage breast cancer treated with breast-conserving surgery, randomized trials have found little difference in local control and survival outcomes between patients treated with conventionally fractionated (CF-) whole breast i ... Full text Link to item Cite

Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2011 Featured Publication PURPOSE: To present guidance for patients and physicians regarding the use of radiotherapy in the treatment of bone metastases according to current published evidence and complemented by expert opinion. METHODS AND MATERIALS: A systematic search of the Nat ... Full text Link to item Cite

Palliative thoracic radiotherapy in lung cancer: An American Society for Radiation Oncology evidence-based clinical practice guideline.

Journal Article Pract Radiat Oncol · 2011 PURPOSE: To provide guidance to physicians and patients with regard to the use of external beam radiotherapy, endobronchial brachytherapy, and concurrent chemotherapy in the setting of palliative thoracic treatment for lung cancer, based on available evide ... Full text Link to item Cite

Radiation dose-volume effects in the brain.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 Featured Publication We have reviewed the published data regarding radiotherapy (RT)-induced brain injury. Radiation necrosis appears a median of 1-2 years after RT; however, cognitive decline develops over many years. The incidence and severity is dose and volume dependent an ... Full text Link to item Cite

Imaging for assessment of radiation-induced normal tissue effects.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 Featured Publication Imaging can provide quantitative assessment of radiation-induced normal tissue effects. Identifying an early sign of normal tissue damage with imaging would have the potential to predict organ dysfunction, thereby allowing reoptimization of treatment strat ... Full text Link to item Cite

A Multidisciplinary Consensus Recommendation on a Synoptic Radiation Treatment Summary: A Commission on Cancer Workgroup Report.

Journal Article Pract Radiat Oncol · 2020 PURPOSE: The radiation treatment summary provides a clinical and technical overview of a patient's full course of radiation therapy. Despite its importance to multiple stakeholders, there is no widely followed radiation treatment summary template. METHODS ... Full text Link to item Cite

Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline.

Journal Article Pract Radiat Oncol · 2018 INTRODUCTION: The purpose of this guideline is to offer recommendations on fractionation for whole breast irradiation (WBI) with or without a tumor bed boost and guidance on treatment planning and delivery. METHODS AND MATERIALS: The American Society for R ... Full text Link to item Cite

Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline.

Journal Article Pract Radiat Oncol · 2017 PURPOSE: The purpose is to provide an update the Bone Metastases Guideline published in 2011 based on evidence complemented by expert opinion. The update will discuss new high-quality literature for the 8 key questions from the original guideline and impli ... Full text Link to item Cite

“Choosing Wisely”: The American Society for Radiation Oncology’s Top 5 List

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Choosing wisely: the American Society for Radiation Oncology's top 5 list.

Journal Article Pract Radiat Oncol · 2014 PURPOSE: To highlight 5 interventions that patients should question, as part of the Choosing Wisely campaign. This initiative, led by the American Board of Internal Medicine Foundation, fosters conversations between physicians and patients about treatments ... Full text Link to item Cite

Adjuvant and salvage radiotherapy after prostatectomy: AUA/ASTRO Guideline.

Journal Article J Urol · August 2013 PURPOSE: The purpose of this guideline is to provide a clinical framework for the use of radiotherapy after radical prostatectomy as adjuvant or salvage therapy. MATERIALS AND METHODS: A systematic literature review using the PubMed®, Embase, and Cochrane ... Full text Link to item Cite

Adjuvant and salvage radiation therapy after prostatectomy: American Society for Radiation Oncology/American Urological Association guidelines.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2013 PURPOSE: The purpose of this guideline was to provide a clinical framework for the use of radiation therapy after radical prostatectomy as adjuvant or salvage therapy. METHODS AND MATERIALS: A systematic literature review using PubMed, Embase, and Cochrane ... Full text Link to item Cite

International practice survey on the management of brain metastases: Third International Consensus Workshop on Palliative Radiotherapy and Symptom Control.

Journal Article Clin Oncol (R Coll Radiol) · August 2012 AIM: To evaluate international patterns of practice for the management of metastatic disease to the brain. MATERIALS AND METHODS: An online international practice survey was conducted from April to June 2010. Most of the survey questions were based on comm ... Full text Link to item Cite

An international survey on liver metastases radiotherapy.

Journal Article Acta Oncol · May 2012 BACKGROUND: An international survey of radiation therapy (RT) of liver metastases was undertaken by the Liver Cancer Workgroup of the Third International Consensus on Metastases Workshop at the 2010 American Society for Radiation Oncology (ASTRO) meeting. ... Full text Link to item Cite

International practice survey on palliative lung radiotherapy: third international consensus workshop on palliative radiotherapy and symptom control.

Journal Article Clin Lung Cancer · May 2012 BACKGROUND: The purpose of this work was to disseminate international practice survey results created in conjunction with the Third International Lung Cancer Consensus Workshop. PATIENTS AND METHODS: In conjunction with the American Society for Radiation O ... Full text Link to item Cite

Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2012 PURPOSE: To update the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases by surveying international experts regarding previous uncertainties within the 2002 consensus, changes that may be necessary b ... Full text Link to item Cite

Consensus statement on palliative lung radiotherapy: third international consensus workshop on palliative radiotherapy and symptom control.

Journal Article Clin Lung Cancer · January 2012 The purpose of this work is to disseminate a consensus statement on palliative radiotherapy (RT) of lung cancer created in conjunction with the Third International Lung Cancer Consensus Workshop. The palliative lung RT workshop committee agreed on 5 questi ... Full text Link to item Cite

Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): An American Society for Radiation Oncology evidence-based guideline.

Journal Article Pract Radiat Oncol · 2012 PURPOSE: To systematically review the evidence for the radiotherapeutic and surgical management of patients newly diagnosed with intraparenchymal brain metastases. METHODS AND MATERIALS: Key clinical questions to be addressed in this evidence-based Guideli ... Full text Link to item Cite

Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2011 Featured Publication PURPOSE: In patients with early-stage breast cancer treated with breast-conserving surgery, randomized trials have found little difference in local control and survival outcomes between patients treated with conventionally fractionated (CF-) whole breast i ... Full text Link to item Cite

Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2011 Featured Publication PURPOSE: To present guidance for patients and physicians regarding the use of radiotherapy in the treatment of bone metastases according to current published evidence and complemented by expert opinion. METHODS AND MATERIALS: A systematic search of the Nat ... Full text Link to item Cite

Palliative thoracic radiotherapy in lung cancer: An American Society for Radiation Oncology evidence-based clinical practice guideline.

Journal Article Pract Radiat Oncol · 2011 PURPOSE: To provide guidance to physicians and patients with regard to the use of external beam radiotherapy, endobronchial brachytherapy, and concurrent chemotherapy in the setting of palliative thoracic treatment for lung cancer, based on available evide ... Full text Link to item Cite

Radiation dose-volume effects in the brain.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 Featured Publication We have reviewed the published data regarding radiotherapy (RT)-induced brain injury. Radiation necrosis appears a median of 1-2 years after RT; however, cognitive decline develops over many years. The incidence and severity is dose and volume dependent an ... Full text Link to item Cite

Imaging for assessment of radiation-induced normal tissue effects.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2010 Featured Publication Imaging can provide quantitative assessment of radiation-induced normal tissue effects. Identifying an early sign of normal tissue damage with imaging would have the potential to predict organ dysfunction, thereby allowing reoptimization of treatment strat ... Full text Link to item Cite

Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy.

Journal Article Neuro Oncol · February 2010 Featured Publication The aim of the study was to determine if biochemical changes indicative of injury, assessed using magnetic resonance spectroscopic imaging (SI), are observed after stereotactic radiosurgery (SRS). The study included patients who underwent SI immediately be ... Full text Link to item Cite

In Reply to Dr. Beal et al

Journal Article International Journal of Radiation Oncology Biology Physics · February 1, 2010 Full text Cite

Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO).

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2009 Featured Publication PURPOSE: To present guidance for patients and physicians regarding the use of accelerated partial-breast irradiation (APBI), based on current published evidence complemented by expert opinion. METHODS AND MATERIALS: A systematic search of the National Libr ... Full text Link to item Cite

Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2009 Featured Publication PURPOSE: A prospective study was performed to formally relate dose-dependent radiologically defined changes in normal brain induced by radiotherapy (RT) to neurocognitive dysfunction in subjects with primary brain tumors. METHODS AND MATERIALS: Adult patie ... Full text Link to item Cite

Morbidity and prostate-specific antigen control of external beam radiation therapy plus low-dose-rate brachytherapy boost for low, intermediate, and high-risk prostate cancer.

Journal Article Brachytherapy · 2009 Featured Publication PURPOSE: Dose escalation has been shown beneficial in prostate cancer. Brachytherapy (BT) provides an opportunity for dose escalation beyond what can be safely delivered using only teletherapy methods. The purpose of this study was to determine cancer cont ... Full text Link to item Cite

Bioimaging In Vivo to Discern the Evolution of Late Effects Temporally and Spatially

Conference CANCER SURVIVORSHIP RESEARCH AND EDUCATION: LATE EFFECTS ON NORMAL TISSUES, CURED II · January 1, 2008 Link to item Cite

A Randomized Prospective Trial of the Effect of Video Radiation Oncology Education on Patient Anxiety

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

The role of functional imaging in the diagnosis and management of late normal tissue injury.

Journal Article Semin Radiat Oncol · April 2007 Featured Publication Normal tissue injury after radiation therapy (RT) can be defined based on either clinical symptoms or laboratory/radiologic tests. In the research setting, functional imaging (eg, single-photon emission computed tomography [SPECT], positron-emission tomogr ... Full text Link to item Cite

Prospective trial of a video educational tool for radiation oncology patients.

Journal Article Am J Clin Oncol · December 2005 Featured Publication OBJECTIVES: Prospective assessment of the informational needs of radiation oncology patients and efficacy of an educational video in meeting them. METHODS: Subjects completed baseline self-administered questionnaires and subsequently viewed the patient edu ... Full text Link to item Cite

Dose-Dependent Effects of Radiation Therapy on Cerebral Blood Flow, Metabolism and Neurocognitive Dysfunction

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer.

Journal Article Int J Hyperthermia · June 2005 Featured Publication OBJECTIVE: A phase I/II study of Doxil combined with whole abdomen hyperthermia was conducted in patients with refractory ovarian cancer. Liposomal doxorubicin combined with hyperthermia has been shown to increase both liposomal delivery and drug extravasa ... Full text Link to item Cite

Prospective assessment of quality of life in ovarian cancer patients receiving whole abdomen hyperthermia and liposomal doxorubicin.

Journal Article Int J Hyperthermia · June 2005 Featured Publication PURPOSE: Prospective assessment of quality of life (QoL) in patients with refractory, residual or recurrent ovarian cancer receiving whole abdomen hyperthermia and intravenous liposomal doxorubicin chemotherapy. METHODS: Treatment consisted of six cycles o ... Full text Link to item Cite

SU‐FF‐T‐366: Radiation Dose Response Curve of Human Cerebral Cortex Measured with [F‐18]‐FDG and [O‐15]‐H2O PET Imaging

Conference Medical Physics · January 1, 2005 Purpose: To study radiotherapy (RT)‐induced dose‐dependent functional changes in the human cerebral cortex region using serial [formula omitted] and [formula omitted] PET imaging before and after RT. Method and Materials: Eleven human subjects were enrolle ... Full text Cite

Routine screening for depression in radiation oncology patients.

Journal Article Am J Clin Oncol · October 2004 Featured Publication PURPOSE: Depression is a debilitating illness with symptoms that overlap those of cancer and radiotherapy. We sought to measure the frequency of depression in adult radiation oncology patients. METHODS AND MATERIALS: The Beck Depression Inventory-II (BDI-I ... Full text Link to item Cite

Adjuvant and salvage radiotherapy following radical prostatectomy

Conference International Journal of Radiation OncologyBiologyPhysics · September 2004 Full text Cite

Prospective trial of a video educational tool for radiation oncology patients

Conference International Journal of Radiation OncologyBiologyPhysics · September 2004 Full text Cite

Phase I/II trial of intravenous liposomal doxorubicin and whole abdomen hyperthermia in patients with refractory ovarian cancer.

Journal Article J Clin Oncol · July 15, 2004 5089 Background: A phase I/II study of liposomal doxorubicin combined with whole abdominal hyperthermia was conducted in patients with refractory ovarian cancer. Liposomal doxorubicin combined with hyperthermia has been shown to increase liposomal extravas ... Link to item Cite

Breast conservation rates-barriers between tertiary care and community practice.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2003 Featured Publication PURPOSE: Low rates of breast conservation therapy (BCT) are reported in the southern United States. We evaluated the influence on BCT rates of opening a radiotherapy (RT) clinic at a community hospital in North Carolina. Before opening, RT was available 5 ... Full text Link to item Cite

Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2003 Featured Publication PURPOSE: To identify the characteristics of adult patients with newly diagnosed primary brain tumors associated with identifiable deficits in neuropsychologic function to target interventions to improve function and quality of life (QOL). MATERIALS AND MET ... Full text Link to item Cite

Gastrointestinal toxicity of transperineal interstitial prostate brachytherapy.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2002 Featured Publication PURPOSE: To characterize the severity and time course of rectal toxicity following transperineal prostate brachytherapy using prospectively recorded data, and to determine factors associated with toxicity. METHODS AND MATERIALS: One hundred thirty-four pat ... Full text Link to item Cite

External beam radiotherapy for thyroid eye disease

Chapter · January 1, 2002 Fractionated external beam radiotherapy is a commonly used treatment for Graves’-associated orbital disease. The data supporting this therapy largely reside in single-institution retrospective reviews. The limited randomized prospective data present a mixe ... Cite

Computed axial tomography tandem and ovoids (CATTO) dosimetry: three-dimensional assessment of bladder and rectal doses.

Journal Article Radiat Oncol Investig · 1998 Featured Publication The purpose of this work is to compare bladder and rectal dose rates in brachytherapy for carcinoma of the cervix using two different dosimetry systems: traditional orthogonal radiograph-based dosimetry vs. computed axial tomography tandem and ovoids (CATT ... Full text Link to item Cite