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Carolyn Louise Lekavich

Assistant Professor in Medicine
Medicine, Cardiology
DUMC Box 3126, Durham, NC 27710
200 Trent Drive, Duke South Rm 4228 Orange Zone, Durham, NC 27710

Selected Publications


Cognitive Impairment in Heart Failure: A Heart Failure Society of America Scientific Statement.

Journal Article J Card Fail · March 2024 Cognitive impairment is common among adults with heart failure (HF), as both diseases are strongly related to advancing age and multimorbidity (including both cardiovascular and noncardiovascular conditions). Moreover, HF itself can contribute to alteratio ... Full text Link to item Cite

Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association.

Journal Article Circulation · November 14, 2023 Cardiovascular-kidney-metabolic health reflects the interplay among metabolic risk factors, chronic kidney disease, and the cardiovascular system and has profound impacts on morbidity and mortality. There are multisystem consequences of poor cardiovascular ... Full text Link to item Cite

A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association.

Journal Article Circulation · November 14, 2023 A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led to the conceptualization of cardiovascular-kidney-metabolic syndrome. The c ... Full text Link to item Cite

Early Identification of Patients at Risk for Incident Heart Failure With Preserved Ejection Fraction: Novel Approach to Echocardiographic Trends.

Journal Article J Card Fail · September 2021 BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) continues to increase in prevalence with a 50% mortality rate within 3 years of diagnosis, but lacking effective evidence-based therapies. Specific echocardiographic markers are not typical ... Full text Link to item Cite

Aerobic Versus Resistance Training Effects on Ventricular-Arterial Coupling and Vascular Function in the STRRIDE-AT/RT Trial.

Journal Article Front Cardiovasc Med · 2021 Background: The goal was studying the differential effects of aerobic training (AT) vs. resistance training (RT) on cardiac and peripheral arterial capacity on cardiopulmonary (CP) and peripheral vascular (PV) function in sedentary and obese adults. Method ... Full text Link to item Cite

Applications of the Multisensor HeartLogic Heart Failure Monitoring Algorithm During the COVID-19 Global Pandemic.

Journal Article JACC Case Rep · November 18, 2020 In the COVID-19 era, the heart failure community has witnessed an unprecedented reduction in heart failure-related patient visits and hospitalizations. Social distancing measures present a dilemma for patients with heart failure who require frequent survei ... Full text Open Access Link to item Cite

Abstract P481: Early Recognition of Heart Failure With Preserved Ejection Fraction (HFpEF): Ventricular Elastance as a Predictive Marker for Prevention and Treatment

Conference Circulation · March 3, 2020 Introduction: Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, carries a 50% mortality rate within 3 years of diagnosis with evidence to support early l ... Full text Cite

Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America: This statement does not represent an update of the 2017 ACC/AHA/HFSA heart failure guideline update.

Journal Article Circulation · August 13, 2019 Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden o ... Full text Link to item Cite

Nutrition, Obesity, and Cachexia in Patients With Heart Failure: A Consensus Statement from the Heart Failure Society of America Scientific Statements Committee.

Journal Article J Card Fail · May 2019 Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive diets can lead to ... Full text Link to item Cite

Measures of Ventricular-Arterial Coupling and Incident Heart Failure With Preserved Ejection Fraction: A Matched Case-Control Analysis.

Conference J Card Fail · September 2017 BACKGROUND: Evidence continues to demonstrate increasing prevalence, cost, and mortality implications of heart failure with preserved ejection fraction (HFpEF), but clearly defined parameters that distinguish between control subjects and HFpEF have not bee ... Full text Link to item Cite

A Critical Evaluation of the Representation of Black Patients With Heart Failure and Preserved Ejection Fraction in Clinical Trials: A Literature Review.

Journal Article J Cardiovasc Nurs · 2016 BACKGROUND: In the United States, heart failure costs $34.4 billion annually and is associated with a mortality rate of 20% within 5 years of diagnosis. Heart failure preserved ejection fraction (HFpEF) accounts for 50% of all hospital admissions for heart ... Full text Link to item Cite

Heart failure preserved ejection fraction (HFpEF): an integrated and strategic review.

Journal Article Heart Fail Rev · November 2015 In the USA, 5.7 million Americans ≥20 years have heart failure (HF) and heart failure preserved ejection fraction (HFpEF) accounts for at least 50 % of all hospital admissions for HF. HFpEF has no single guideline for diagnosis or treatment, the patient po ... Full text Link to item Cite

Measures of Ventricular Arterial Elastance

Journal Article Journal of Cardiac Failure Cite