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Claude Lebernian Hughes Jr.

Consulting Professor of Obstetrics and Gynecology
Obstetrics and Gynecology
Duke Box 12194, Iqvia, Morrisville, NC 27560
5927 S. Miami Blvd., Iqvia, Morrisville, NC 27560

Selected Publications


Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada.

Journal Article Sci Rep · May 9, 2023 Gastroschisis has increased globally over recent decades, and this increase has not been explained by identified risk factors. We conducted a population-based study of infants born in Canada, 2004-2020. We used "winter" months (i.e., September through June ... Full text Open Access Link to item Cite

Pre-birth acquisition of personhood: Incremental accrual of attributes as the framework for individualization by serial and concurrently acting developmental factors.

Journal Article Front Reprod Health · 2023 Discrete events and processes influence development of individual humans. Attribution of personhood to any individual human being cannot be disconnected from the underlying biological events and processes of early human development. Nonetheless, the philos ... Full text Open Access Link to item Cite

Preface

Chapter · April 27, 2022 Cite

The Coronavirus Pandemic and the Future Virology, Epidemiology, Translational Toxicology and Therapeutics, Volume 2

Book · April 25, 2022 This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to ... ... Cite

Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: The special case of molnupiravir.

Journal Article Environ Mol Mutagen · January 2022 This review considers antiviral nucleoside analog drugs, including ribavirin, favipiravir, and molnupiravir, which induce genome error catastrophe in SARS-CoV or SARS-CoV-2 via lethal mutagenesis as a mode of action. In vitro data indicate that molnupiravi ... Full text Open Access Link to item Cite

The Coronavirus Pandemic and the Future Virology, Epidemiology, Translational Toxicology and Therapeutics, Volume 1

Book · December 14, 2021 By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public ... ... Cite

Ecological Analysis of Gastroschisis Incidence Decline in Liaoning, China, 2006-2016

Journal Article Global Clinical and Translational Research · December 30, 2020 Background: A gastroschisis incidence decline has recently been reported in Liaoning, China, from 2006-2015; we suspect that this decline could be associated with the fall in industrial manufacturing activities. Methods: The outcome variable, gast ... Full text Open Access Cite

Reflections and Forethoughts on Global Clinical and Translational Research

Journal Article Global Clinical and Translational Research · December 30, 2020 Full text Open Access Cite

Clinical Epidemiology of Coronavirus Disease 2019: Defined on Current Research

Journal Article Global Clinical and Translational Research · July 25, 2020 Full text Open Access Cite

A caution in association of ABO blood group with COVID-19

Journal Article Global Clinical and Translational Research · June 10, 2020 Full text Open Access Cite

Beyond p-value: the Rigor and Power of Study

Journal Article Global Clinical and Translational Research · January 10, 2020 There have been a series of recent discussions and debates on the p-value and statistical significance. These discussions, including publications of more than 40 papers in a special issue of the American Statistician, provide an excellent opportuni ... Full text Open Access Cite

Reply to Comments on "Beyond P-value: the Rigor and Power of Study"

Journal Article Global Clinical and Translational Research · January 10, 2020 We received commentaries that included comments on our paper. Here we provide replies to the comments in the order received. To avoid confusion, we made a revision in the Table 1 to assure that level of significance and power at specified effect si ... Full text Open Access Cite

Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada.

Journal Article Sci Rep · May 9, 2023 Gastroschisis has increased globally over recent decades, and this increase has not been explained by identified risk factors. We conducted a population-based study of infants born in Canada, 2004-2020. We used "winter" months (i.e., September through June ... Full text Open Access Link to item Cite

Pre-birth acquisition of personhood: Incremental accrual of attributes as the framework for individualization by serial and concurrently acting developmental factors.

Journal Article Front Reprod Health · 2023 Discrete events and processes influence development of individual humans. Attribution of personhood to any individual human being cannot be disconnected from the underlying biological events and processes of early human development. Nonetheless, the philos ... Full text Open Access Link to item Cite

Preface

Chapter · April 27, 2022 Cite

The Coronavirus Pandemic and the Future Virology, Epidemiology, Translational Toxicology and Therapeutics, Volume 2

Book · April 25, 2022 This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to ... ... Cite

Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: The special case of molnupiravir.

Journal Article Environ Mol Mutagen · January 2022 This review considers antiviral nucleoside analog drugs, including ribavirin, favipiravir, and molnupiravir, which induce genome error catastrophe in SARS-CoV or SARS-CoV-2 via lethal mutagenesis as a mode of action. In vitro data indicate that molnupiravi ... Full text Open Access Link to item Cite

The Coronavirus Pandemic and the Future Virology, Epidemiology, Translational Toxicology and Therapeutics, Volume 1

Book · December 14, 2021 By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public ... ... Cite

Ecological Analysis of Gastroschisis Incidence Decline in Liaoning, China, 2006-2016

Journal Article Global Clinical and Translational Research · December 30, 2020 Background: A gastroschisis incidence decline has recently been reported in Liaoning, China, from 2006-2015; we suspect that this decline could be associated with the fall in industrial manufacturing activities. Methods: The outcome variable, gast ... Full text Open Access Cite

Reflections and Forethoughts on Global Clinical and Translational Research

Journal Article Global Clinical and Translational Research · December 30, 2020 Full text Open Access Cite

Clinical Epidemiology of Coronavirus Disease 2019: Defined on Current Research

Journal Article Global Clinical and Translational Research · July 25, 2020 Full text Open Access Cite

A caution in association of ABO blood group with COVID-19

Journal Article Global Clinical and Translational Research · June 10, 2020 Full text Open Access Cite

Beyond p-value: the Rigor and Power of Study

Journal Article Global Clinical and Translational Research · January 10, 2020 There have been a series of recent discussions and debates on the p-value and statistical significance. These discussions, including publications of more than 40 papers in a special issue of the American Statistician, provide an excellent opportuni ... Full text Open Access Cite

Reply to Comments on "Beyond P-value: the Rigor and Power of Study"

Journal Article Global Clinical and Translational Research · January 10, 2020 We received commentaries that included comments on our paper. Here we provide replies to the comments in the order received. To avoid confusion, we made a revision in the Table 1 to assure that level of significance and power at specified effect si ... Full text Open Access Cite

Prenatal Environment and Perinatal Factors Associated with Autism Spectrum Disorder

Journal Article Global Clinical and Translational Research · September 30, 2019 Background: Both genetic and epidemiological studies have indicated that environmental factors play an essential role in the development of autism spectrum disorder (ASD). We conducted this study to identify maternal exposure to environmental facto ... Full text Open Access Cite

Interpretation of the Environmental Impact on Autism Spectrum Disorder

Journal Article Global Clinical and Translational Research · September 30, 2019 Comments on Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders. Cell Res. 2019. https://www.nature.com/articles/s41422-019-0220-1, PMID:31462724 ... Full text Open Access Cite

Reporting standards for clinical and translational research

Journal Article Global Clinical and Translational Research · April 16, 2019 Full text Open Access Cite

New Journal Launch: Global Clinical and Translational Research

Journal Article Global Clinical and Translational Research · March 30, 2019 We are proud to announce the launch of Global Clinical and Translational Research, a new journal that aims to promote clinical and translational research in the genomic era from a global perspective. The journal will (1) provide a unified platform ... Full text Open Access Cite

What Stressors Cause Cancer and When?

Chapter · November 21, 2016 Translational biomedical research seeks to move laboratory findings based on models (in silico, in vitro, and in vivo) into human clinical trials to more expeditiously develop specific therapeutics, and then back again to the laboratory to inform future di ... Full text Cite

Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer

Book · November 21, 2016 Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that ... Full text Cite

Translational Toxicology Defining a New Therapeutic Discipline

Book · March 23, 2016 Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, ... ... Cite

The opportunity to translate developmental toxicology into a therapeutic discipline

Chapter · January 1, 2016 Since presentation of our view of translational developmental toxicology in 2013, numerous investigations from a wide range of approaches have added to the evidence underlying our core premise; namely that as the potential adverse developmental effects fro ... Full text Cite

Ligand-mediated toxicology: Characterization and translational prospects

Chapter · January 1, 2016 In biochemistry a ligand is a molecule that binds to a receptor or other biomolecule that forms a complex and produces a biological effect. We live in a world of exposure to exogenous ligands and there are three long-established strands of biological resea ... Full text Cite

Preface

Book · January 1, 2016 Cite

Application of the estrogen threshold hypothesis to the physiologic hypoestrogenemia of lactation.

Journal Article Breastfeed Med · March 2015 OBJECTIVE: This study determined the impact of breastfeeding on hypoestrogenic symptoms among women in the postpartum period and correlated these findings with the Estrogen Threshold Hypothesis, which postulates that the hypoestrogenic symptoms experienced ... Full text Open Access Link to item Cite

An Update on Surgical versus Expectant Management of Ovarian Endometriomas in Infertile Women.

Journal Article Biomed Res Int · 2015 Ovarian endometriomas are a common manifestation of endometriosis that can represent a more severe stage of the disease. There is much debate over the treatment of these cysts in infertile women, particularly before use of assisted reproductive technologie ... Full text Open Access Link to item Cite

The Impact of Endometriosis across the Lifespan of Women: Foreseeable Research and Therapeutic Prospects.

Journal Article Biomed Res Int · 2015 In addition to estrogen dependence, endometriosis is characterized by chronic pelvic inflammation. The impact of the chronic pelvic inflammatory state on other organ systems and women's health is unclear. Endometriosis associated chronic inflammation and p ... Full text Open Access Link to item Cite

Modeling endocrine control of the pituitary-ovarian axis: androgenic influence and chaotic dynamics.

Journal Article Bull Math Biol · January 2014 Mathematical models of the hypothalamus-pituitary-ovarian axis in women were first developed by Schlosser and Selgrade in 1999, with subsequent models of Harris-Clark et al. (Bull. Math. Biol. 65(1):157-173, 2003) and Pasteur and Selgrade (Understanding th ... Full text Open Access Link to item Cite

Translational toxicology: a developmental focus for integrated research strategies.

Journal Article BMC Pharmacol Toxicol · September 30, 2013 BACKGROUND: Given that toxicology studies the potential adverse effects of environmental exposures on various forms of life and that clinical toxicology typically focuses on human health effects, what can and should the relatively new term of "translationa ... Full text Open Access Link to item Cite

Effects of Dietary Chromium Methionine on Growth Performance, Carcass Composition, Meat Colour and Expression of the Colour-related Gene Myoglobin of Growing-finishing Pigs.

Journal Article Asian-Australas J Anim Sci · July 2013 To investigate the effect of dietary chromium (Cr) as Cr methionine (CrMet) on growth performance, carcass traits, pork quality, meat colour and expression of meat colour-related genes in growing-finishing pigs, 189 crossbred Duroc×(Landrace×Yorkshire) gro ... Full text Open Access Link to item Cite

Cigarette smoking and ovarian function

Chapter · January 1, 2013 The global prevalence of infertility is estimated to be 9% [1] and between 50 and 80 million people worldwide are infertile [2]. Advanced age, diet, prescription medication use, preexisting health status, and infections are among the known risk factors for ... Full text Cite

Inhibition of Neu-induced mammary carcinogenesis in transgenic mice expressing ERΔ3, a dominant negative estrogen receptor α variant.

Journal Article Horm Cancer · December 2012 The estrogen receptor α (ERα) splicing variant with an in-frame deletion of exon 3 (ERΔ3) is frequently expressed in the normal breast, but its influence on tumorigenesis has not been explored. In vitro, ERΔ3 has dominant negative activity, suggesting it m ... Full text Open Access Link to item Cite

Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults.

Journal Article J Gerontol A Biol Sci Med Sci · October 2011 Based on the multiple logistic regression analysis of data from a random sample of 1,023 old adults collected in Taiwan in 2000, we found that interactions between carrying the APOE4 allele and one of four life stress factors (relocated mainlander, living ... Full text Open Access Link to item Cite

Effects of dietary allicin on health and growth performance of weanling piglets and reduction in attractiveness of faeces to flies.

Journal Article Animal · February 2011 To investigate the effect of dietary allicin on health and growth performance of weanling piglets, at 21 days of age. Two hundred and twenty-five piglets were weaned and randomly allocated into five groups. Piglets in the control group were fed diets suppl ... Full text Open Access Link to item Cite

Alcohol, drugs, caffeine, tobacco, and environmental contaminant exposure: reproductive health consequences and clinical implications.

Journal Article Crit Rev Toxicol · August 2010 Reproductive function and fertility are thought to be compromised by behaviors such as cigarette smoking, substance abuse, and alcohol consumption; however, the strength of these associations are uncertain. Furthermore, the reproductive system is thought t ... Full text Open Access Link to item Cite

Interrelationships between ovarian and pituitary hormones in ovulatory menstrual cycles across reproductive age.

Journal Article J Clin Endocrinol Metab · January 2009 CONTEXT: Ovarian hormones regulate pituitary gonadotropin secretion across the menstrual cycle via negative and positive feedback mechanisms. The contribution of individual hormones is complex and is a continuing area of research. OBJECTIVE: The aim of the ... Full text Link to item Cite

Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition.

Journal Article Menopause · 2009 OBJECTIVE: The menopausal transition is characterized by irregular menstrual cycles and unpredictable hormone levels, including dramatic swings in estradiol (E2). An increasing number of studies have found variable high E2 and low luteal phase progesterone ... Full text Link to item Cite

Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2.

Journal Article Cancer Res · October 15, 2008 Black cohosh is an herbal extract that is often used as an alternative to estrogen-based replacement therapies to treat hot flushes that frequently accompany the transition to menopause. Although cancer-free women as well as breast cancer patients and surv ... Full text Open Access Link to item Cite

A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles.

Journal Article Menopause · 2008 OBJECTIVE: To characterize menstrual cycles in women in late reproductive age and the menopause transition, based on changes in serum hormone levels. DESIGN: Serum levels of estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone, ... Full text Link to item Cite

Endocrine features of menstrual cycles in middle and late reproductive age and the menopausal transition classified according to the Staging of Reproductive Aging Workshop (STRAW) staging system.

Journal Article J Clin Endocrinol Metab · August 2007 CONTEXT: Female reproductive aging based on changes in menstrual cycle length and frequency progresses through a number of stages as defined by the Stages of Reproductive Aging Workshop (STRAW) staging criteria. OBJECTIVE: This paper provides a comprehensi ... Full text Link to item Cite

Effect of the isoflavone genistein against galactose-induced cataracts in rats.

Journal Article Exp Biol Med (Maywood) · January 2007 Worldwide, ocular cataracts are a major cause of human blindness. A key goal of cataract-related research is to identify simple, cost-efficient but effective ways to prevent cataract formation or progression. Genistein is a naturally occurring dietary isof ... Link to item Cite

Bisphenol A: Vom Saal and Hughes respond [2]

Journal Article Environmental Health Perspectives · January 1, 2006 Full text Cite

Dietary galactose inhibits GDF-9 mediated follicular development in the rat ovary.

Journal Article Reprod Toxicol · January 2006 Clinical evidence suggests an association between galactosemia and premature ovarian failure, but the mechanism is still not fully understood. Growth differentiation factor-9 (GDF-9) is thought to be an obligatory growth factor during the gonadotropin-inde ... Full text Link to item Cite

Dioxin-like activity and maternal thyroid hormone levels in second trimester maternal serum.

Journal Article Am J Obstet Gynecol · December 2005 OBJECTIVE: Developmental exposure to dioxin-like compounds has been associated with cognitive and motor impairments in children. These toxicants have been shown to be thyroid toxicants in animal studies. Therefore, the objective of this study was to quanti ... Full text Link to item Cite

An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment.

Journal Article Environ Health Perspect · August 2005 Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based polymers are subject to hydrolysis, ... Full text Open Access Link to item Cite

Ovarian effects of a high lactose diet in the female rat.

Journal Article Reprod Nutr Dev · 2005 Young women with galactosemia experience ovarian failure at a very early age raising concern about the ovarian toxicity of galactose. While galactose may be present in the diet as a monosaccharide, it is predominantly derived from cleavage of the disacchar ... Full text Link to item Cite

Weight of the evidence evaluation of low-dose reproductive and developmental effects of bisphenol A

Journal Article Human and Ecological Risk Assessment · October 1, 2004 A panel convened by the Harvard Center for Risk Analysis (HCRA) evaluated the weight of evidence for potential developmental and reproductive toxicity of bisphenol A (BPA, CASRN 80-05-7) in animals at doses well below the Lowest Observed Adverse Effect Lev ... Full text Cite

Effects of genistein or soy milk during late gestation and lactation on adult uterine organization in the rat.

Journal Article Exp Biol Med (Maywood) · January 2004 In utero and lactational exposure to estrogenic agents has been shown to influence morphological and functional development of reproductive tissues. Thus, consumption of dietary phytoestrogens, such as isoflavones, during pregnancy and lactation could infl ... Full text Link to item Cite

Mammary gland morphology in Sprague-Dawley rats following treatment with an organochlorine mixture in utero and neonatal genistein.

Journal Article Toxicol Sci · January 2004 In a related reproductive toxicology study designed to investigate the effects of in utero exposure to environmental toxicants and potential interaction with postnatal genistein, gross enlargement of thoracic mammary glands was observed in female offspring ... Full text Link to item Cite

Metabolic effects of dietary lactose in adult female rats.

Journal Article Reprod Nutr Dev · 2003 As an outgrowth of our interest in the potential toxicity of dietary galactose, we investigated the metabolic effects of high lactose diets in Long-Evans female rats. Seventy-five Long-Evans female rats (25-day-old) were randomized to receive one of 3 diet ... Full text Link to item Cite

Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency.

Journal Article J Med Food · 2003 Soy has received attention as an alternative to conventional hormone replacement therapy (HRT) largely because it is a unique dietary source of isoflavones. Isoflavones are diphenolic compounds that have both hormonal and nonhormonal properties and are con ... Full text Link to item Cite

Human developmental exposure to endocrine active compounds.

Journal Article Environ Toxicol Pharmacol · September 2002 Quantification of exposure to environmental contaminants such as endocrine active chemicals (EACs) during critical periods of development, particularly in utero, remains largely unexplored. Therefore, we tested the hypothesis that EACs can be detected and ... Full text Link to item Cite

Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium.

Journal Article Toxicol Sci · June 2002 The human population in the industrialized world is ubiquitously exposed to complex mixtures of persistent pollutants that contaminate food, water, and air. A large number of these contaminants have been shown to cause significant toxicity to the hypothala ... Full text Link to item Cite

Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: systemic, immune, and reproductive effects.

Journal Article Toxicol Sci · May 2002 Human populations throughout the world are exposed daily to low levels of environmental contaminants. The consequences of potential interactions of these compounds to human endocrine, reproductive, and immune function remain unknown. The current study exam ... Full text Link to item Cite

Detection of phytoestrogens in samples of second trimester human amniotic fluid.

Journal Article Toxicol Lett · March 28, 2002 There is widespread concern that fetal exposure to hormonally active chemicals may adversely affect development of the reproductive tract. Therefore, the present study was performed to develop the necessary analytical methods and test the hypothesis that d ... Full text Link to item Cite

Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta.

Journal Article J Natl Cancer Inst · January 2, 2002 BACKGROUND: Oral contraceptive (OC) use is associated with a reduced risk of ovarian cancer. An OC component, progestin, induces apoptosis in the primate ovarian epithelium. One regulator of apoptosis is transforming growth factor-beta (TGF-beta). We deter ... Full text Link to item Cite

Dietary compounds in relation to dietary diversity and human health.

Journal Article J Med Food · 2002 The human diet contains numerous endocrine-active compounds that influence mammalian physiology. The effects of these dietary compounds may be mediated by interaction with well-characterized intracellular hormone receptors or by other effects on patterns o ... Full text Link to item Cite

Extrapolation of rodent studies on amniotic fluid contaminants to human populations

Journal Article Human and Ecological Risk Assessment (HERA) · December 1, 2001 Cite

A double-blind randomized study on the effects of red clover isoflavones on the endometrium.

Journal Article Menopause · 2001 OBJECTIVE: To assess the effects of a red clover-derived isoflavone extract on the Ki-67 proliferative marker of endometrial biopsies in 45-to 50-year-old perimenopausal women. We hypothesized that we would be able to detect a decrease in the Ki-67 prolife ... Full text Link to item Cite

Detection of endocrine disrupting chemicals in samples of second trimester human amniotic fluid.

Journal Article J Clin Endocrinol Metab · August 2000 Man-made chemicals that have been shown to modulate endocrine function in animal models, so-called "endocrine disrupters", are suspected to play a role in the development of male reproductive tract abnormalities and neurobehaviroal deficits in children. Ho ... Full text Link to item Cite

Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary.

Journal Article Environ Health Perspect · June 2000 This work group report addresses the central question: What are the critical windows during development (preconception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health? The reproductive sy ... Full text Open Access Link to item Cite

Critical windows of exposure for children's health: the reproductive system in animals and humans.

Journal Article Environ Health Perspect · June 2000 Drugs and environmental chemicals can adversely affect the reproductive system. Currently, available data indicate that the consequences of exposure depend on the nature of the chemical, its target, and the timing of exposure relative to critical windows i ... Full text Open Access Link to item Cite

Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats.

Journal Article J Soc Gynecol Investig · 2000 OBJECTIVES: Oral contraceptive (OC) therapy has long been known to produce hypoandrogenemia. However, androgens are not part of any OC therapy available to women. This project was designed to evaluate the effects of low-estradiol containing OC, with or wit ... Link to item Cite

The role of isoflavones in menopausal health: consensus opinion of The North American Menopause Society.

Journal Article Menopause · 2000 OBJECTIVE: Given the increasing interest in the effect of isoflavones on menopause-related symptoms and diseases related to menopause/aging combined with the growing body of published literature on isoflavones, much of which presents conflicting data, The ... Link to item Cite

Galactose metabolism and ovarian toxicity.

Journal Article Reprod Toxicol · 2000 Galactose is an energy-providing nutrient and also a necessary basic substrate for the biosynthesis of many macromolecules in the body. Metabolic pathways for galactose are important not only for the provision of these pathways but also for the prevention ... Full text Link to item Cite

An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults.

Conference Environ Health Perspect · August 1999 The workshop "Characterizing the Effects of Endocrine Disruptors on Human Health at Environmental Exposure Levels" was held to provide a forum for discussions and recommendations of methods and data needed to improve risk assessments of endocrine disruptor ... Full text Open Access Link to item Cite

Environmental contaminants and body fat distribution.

Journal Article Cancer Epidemiol Biomarkers Prev · February 1999 The effect of body mass index (BMI) and waist:hip ratio (WHR) on plasma levels of organochlorines [i.e., 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE)] was investigated in a sample of black and white women drawn from a population-based study in North ... Link to item Cite

Metabolic strategy and social behavior in Lemuridae

Conference NEW DIRECTIONS IN LEMUR STUDIES · 1999 Cite

Effects of dietary soybean estrogens on the reproductive tract in female rats.

Journal Article Proc Soc Exp Biol Med · March 1998 The estrogenic actions of dietary phytoestrogens have raised concerns regarding the potential DES-like developmental effects on the female genital tract, but the growing evidence of cardioprotective benefits of dietary soybean estrogens provides the impetu ... Full text Link to item Cite

Effect of progestin on the ovarian epithelium of macaques: cancer prevention through apoptosis?

Journal Article J Soc Gynecol Investig · 1998 OBJECTIVE: The apoptosis pathway is a vital mechanism in vivo that functions to eradicate genetically damaged cells prone to malignancy. The purpose of this study was to determine whether oral contraceptives, which confer significant protection against sub ... Full text Link to item Cite

Environmental influences on ovarian aging

Conference PERIMENOPAUSE · 1997 Cite

Epithelial ovarian cancer risk among women with polycystic ovary syndrome.

Journal Article Obstet Gynecol · October 1996 OBJECTIVE: To investigate the relationship between polycystic ovary syndrome (PCOS) and ovarian cancer, and to present three hypotheses regarding hormonal factors and the risk of ovarian cancer in women. METHODS: Data were analyzed from a population-based, ... Full text Link to item Cite

Endocrine modulation of reproduction.

Conference Fundam Appl Toxicol · January 1996 The ability of foreign compounds to affect the functioning of various endocrine systems is currently thought responsible for a wide variety of effects. The presentations in this Symposium reviewed the evidence for and against the involvement of endocrine s ... Full text Link to item Cite

Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys.

Journal Article J Nutr · January 1996 Although the beneficial effects of dietary soybean protein compared with animal proteins on plasma lipids, lipoproteins and atherosclerosis have been known for about 50 years, it has been uncertain whether these effects are due to its amino acid concentrat ... Full text Link to item Cite

Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium.

Journal Article Food Chem Toxicol · January 1996 Two experiments evaluating functional endpoints pertaining to the developmental neuroendocrine effects of aluminum in the rat are reported. A total of 31 timed mated dams were fed by daily gastric gavage 0, 5, 25, 50, 250, 500 or 1000 mg/kg body weight/day ... Full text Link to item Cite

Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women.

Journal Article J Clin Endocrinol Metab · May 1995 We tested the hypothesis that postmenopausal women on a soy-supplemented diet show estrogenic responses. Ninety-seven postmenopausal women were randomized to either a group that was provided with soy foods for 4 weeks or a control group that was instructed ... Full text Link to item Cite

Follicle-stimulating hormone concentrations in relation to active and passive smoking.

Journal Article Obstet Gynecol · March 1995 OBJECTIVE: To determine the association between various forms of tobacco exposure and ovarian status, as measured by FSH concentrations, in women 38-49 years old. METHODS: Two hundred ninety women between 38-49 years old, who had not had hysterectomy or oo ... Full text Link to item Cite

The effect of prenatal exposure to the phytoestrogen genistein on sexual differentiation in rats.

Journal Article Proc Soc Exp Biol Med · January 1995 Exposure to naturally occurring estrogens during critical periods of development can alter morphologic and physiologic markers of sexual differentiation. The current experiment characterizes the effects of in utero treatment with genistein, an isoflavonoid ... Full text Link to item Cite

The nonhuman primate model of the relationship between gonadal steroids and coronary heart disease.

Journal Article Prog Cardiovasc Dis · 1995 Experimental data derived from studies using cynomolgus macaque females provide strong evidence that estrogen influences both premenopausal and postmenopausal coronary artery atherosclerosis. Because the monkey studies are not hampered by selection bias, t ... Full text Link to item Cite

Estrogenic soybean isoflavones and chronic disease Risks and benefits.

Journal Article Trends Endocrinol Metab · 1995 Many edible plants contain natural estrogens called phytoestrogens. These compounds possess mixed estrogen agonist-antagonist properties that are organ-specific in vivo. We have focused on estrogenic soybean isoflavones because of their potential extensive ... Full text Link to item Cite

The effect of neonatal exposure to diethylstilbestrol, coumestrol, and beta-sitosterol on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat.

Journal Article Proc Soc Exp Biol Med · January 1995 The neonatal hormone environment influences the sexually differentiated patterns of development. Estrogens, derived from intracerebral aromatization, promote male pattern development of the central nervous system. The purpose of this study was to determine ... Full text Link to item Cite

Galactose consumption, metabolism, and follicle-stimulating hormone concentrations in women of late reproductive age.

Journal Article Fertil Steril · December 1994 OBJECTIVE: To test the hypothesis that high galactose consumption and low activity of galactose-1-phosphate uridyl transferase (transferase) is associated with early ovarian senescence among nongalactosemic women. DESIGN: Cross-sectional study. Data collec ... Link to item Cite

Serum progesterone for the exclusion of early pregnancy in women at risk for recurrent gestational trophoblastic neoplasia.

Journal Article Obstet Gynecol · November 1994 OBJECTIVE: To evaluate the utility of the serum progesterone level for discriminating pregnancy from gestational trophoblastic neoplasia. METHODS: Serum progesterone levels were measured in 61 women with histories of trophoblastic disease who developed a r ... Link to item Cite

The prognostic value of serum concentrations of progesterone, estradiol, and luteinizing hormone during superovulation with and without adjunctive leuprolide therapy.

Journal Article Fertil Steril · June 1993 OBJECTIVE: To determine the predictive value of preovulatory serum concentrations of P, E2, and LH for pregnancy achieved with IUI after superovulation with and without adjunctive leuprolide acetate (LA) therapy. DESIGN: Randomized, crossover study of supe ... Full text Link to item Cite

Effect of neonatal diethylstilbestrol exposure on volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus and pituitary responsiveness to gonadotropin-releasing hormone in female rats of known anogenital distance at birth.

Journal Article Biol Reprod · May 1993 The effects of neonatal diethylstilbestrol (DES) exposure on the volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus (SDN-POA) and on GnRH-stimulated LH secretion were investigated in castrated female rats of known anogenital ... Full text Link to item Cite

hCG, progesterone, alpha-fetoprotein, and estradiol in the identification of ectopic pregnancy.

Journal Article Obstet Gynecol · May 1993 OBJECTIVE: To enhance the laboratory diagnosis of ectopic pregnancy by determining levels of hCG, progesterone, estradiol (E2), and alpha-fetoprotein (AFP). METHODS: Serum samples and medical records were retrospectively analyzed from 100 gynecologic patie ... Link to item Cite

Effect of neonatal diethylstilbestrol exposure on luteinizing hormone secretion following ketamine anesthesia and gonadotropin-releasing hormone in castrated postpubertal rats.

Journal Article Biol Reprod · April 1993 Neonatal diethylstilbestrol (DES) exposure diminishes pituitary responsiveness to GnRH in castrated postpubertal rats 4 h after placement of intra-atrial cannulae under ketamine anesthesia. Ketamine anesthesia has been reported to blunt the preovulatory LH ... Full text Link to item Cite

Dose-response characteristics of neonatal exposure to genistein on pituitary responsiveness to gonadotropin releasing hormone and volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) in postpubertal castrated female rats.

Journal Article Reprod Toxicol · 1993 Estrogen exposure during critical periods of development promotes androgenization of the brain, which is reflected in altered morphology, behavior, and cyclic hormone secretion in females. Previous work in our laboratory demonstrated that neonatal female r ... Full text Link to item Cite

Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone.

Journal Article Endocrinology · September 1992 Lactoferrin (LTF), an iron-binding glycoprotein present in most exocrine secretions and in the secondary granules of polymorphonuclear leucocytes (PMN), is regulated by estrogen in the mouse reproductive tract. We investigated the expression of LTF mRNA an ... Full text Link to item Cite

Anogenital distance at birth as a predictor of volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus and pituitary responsiveness in castrated adult rats.

Journal Article Biol Reprod · January 1992 Variation in anogenital distance (AGD) in female newborn rats depends upon androgenization secondary to transplacental/transmembraneous testosterone from adjacent intrauterine male siblings. Since the size of the sexually dimorphic nucleus of the preoptic ... Full text Link to item Cite

The effect of neonatal exposure to diethylstilbestrol, genistein, and zearalenone on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat.

Journal Article Biol Reprod · October 1991 The neonatal hormone environment determines the sexually differentiated pattern of brain growth. Estrogens, derived from intracerebral aromatization of testosterone, promote male sexual central nervous system (CNS) development. Developing animals may also ... Full text Link to item Cite

Adjunctive leuprolide therapy does not improve cycle fecundity in controlled ovarian hyperstimulation and intrauterine insemination of subfertile women.

Journal Article Obstet Gynecol · August 1991 Problems arising from controlled ovarian hyperstimulation for intrauterine insemination, such as premature luteinization and asynchronous ovarian follicular development, are identical to those encountered with controlled ovarian hyperstimulation for in vit ... Link to item Cite

Reproductive hormone levels in gynecologic oncology patients undergoing surgical castration after spontaneous menopause.

Journal Article Gynecol Oncol · January 1991 The endocrine function of the ovary after menopause is perhaps less well understood than at any other time in the female life cycle. To evaluate the hormonal function of the ovary further at this stage of life, reproductive hormone levels were measured in ... Full text Link to item Cite

The effect of neonatal exposure to DES and o,p'-DDT on pituitary responsiveness to GnRH in adult castrated rats.

Journal Article Reprod Toxicol · 1991 While exposure of vertebrates to estrogens during early development has been shown to alter adult reproductive behavior, neuroanatomy, and neurophysiology, effects on gonadotropin secretion have not been studied. We conducted the present studies to assess ... Full text Link to item Cite

Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomized rat: Part 1.

Journal Article Reprod Toxicol · 1991 Acute pretreatment of ovariectomized rats with genistein (G) alters gonadotropin-releasing hormone-(GnRH)-induced LH secretion in a fashion comparable to estradiol (E2). In the present studies we wished to (A) determine whether G can acutely inhibit tonic ... Full text Link to item Cite

In reply

Journal Article Reproductive Toxicology · January 1, 1991 Full text Cite

Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomized rat: Part 2.

Journal Article Reprod Toxicol · 1991 Acute intravenous administration of the phytoestrogen genistein (G) blocks the gonadotropin-releasing hormone-(GnRH)-induced rise of luteinizing hormone (LH) in ovariectomized rats. The present experiments were performed to determine whether subacute admin ... Full text Link to item Cite

Relationship of laparoscopic findings to self-report of pelvic pain.

Journal Article Am J Obstet Gynecol · January 1991 An assessment battery including standardized measures of behavioral and psychosocial factors associated with other chronic pain conditions was administered to 102 women scheduled for laparoscopic surgery. Surgeons who were blinded to the patient's self-rep ... Full text Link to item Cite

The luteal phase in polycystic ovary syndrome during ovulation induction with human menopausal gonadotropin with and without leuprolide acetate.

Journal Article Fertil Steril · July 1990 Little data exist on the effects of adjunctive therapy with leuprolide acetate (LA) in the luteal phase of women with polycystic ovary syndrome (PCOS) undergoing ovulation induction with human menopausal gonadotropin (hMG). Additionally, it is not known wh ... Full text Link to item Cite

Utility of fluoroimmunoassay in detecting luteinizing hormone surges in spontaneous and human menopausal gonadotropin-stimulated menstrual cycles.

Journal Article J Reprod Med · March 1990 Luteinizing hormone (LH) levels measured with radioimmunoassay and time-resolved fluoroimmunoassay (FIA) in 274 serum samples correlated highly, with a linear correlation coefficient of 0.934. Through the analysis of serial samples from 43 women undergoing ... Link to item Cite

Synthetic estrogens suppress granulosa cell progesterone production in vitro.

Journal Article Reprod Toxicol · 1990 We evaluated the effect of commonly used pharmaceutical estrogens and zeranol, an estrogenic growth-promoting agent used in livestock, on progesterone (P) production by cultures of highly differentiated porcine granulosa cells (GC). The compounds were adde ... Full text Link to item Cite

Use of human cumulus granulosa cells for in vitro screening of reproductive toxicants.

Journal Article Reprod Toxicol · 1990 We investigated the possibility that human granulosa cells from the cumulus mass obtained during human in vitro fertilization/embryo transfer (IVF/ET) might be useful for screening of potential reproductive toxicants in vitro. The cumulus granulosa cells d ... Full text Link to item Cite

Reproductive effects of environmental agents

Journal Article Seminars in Reproductive Endocrinology · January 1, 1990 A comprehensive assessments of the effects of environmental agents (chemicals) on reproduction requires characterization of the context of exposure. Such contextual factors include general physical conditions (temperature, photoperiod, humidity, and so on) ... Full text Cite

Clinical characteristics of ovulation induction with human menopausal gonadotropins with and without leuprolide acetate in polycystic ovary syndrome.

Journal Article Fertil Steril · December 1989 Ovulation induction in polycystic ovary syndrome (PCOS) with human menopausal gonadotropins (hMG) results in suboptimal cycle fecundity and frequently is complicated by ovarian hyperstimulation. The use of a gonadotropin releasing-hormone agonist (Gn-RH-a) ... Full text Link to item Cite

Multiple gestation with intrauterine insemination and menotropin therapy (Reply)

Journal Article American Journal of Obstetrics and Gynecology · December 1, 1989 Cite

Reply

Journal Article American Journal of Obstetrics and Gynecology · December 1989 Full text Cite

Multiple pregnancies conceived with intrauterine insemination during superovulation: an evaluation of clinical characteristics and monitored parameters of conception cycles.

Journal Article Am J Obstet Gynecol · August 1988 The use of human menopausal gonadotropins to induce superovulation in conjunction with intrauterine insemination as treatment for infertility is associated with an increased incidence of multiple gestation. Identification of clinical characteristics and/or ... Full text Link to item Cite

Phytochemical mimicry of reproductive hormones and modulation of herbivore fertility by phytoestrogens.

Journal Article Environ Health Perspect · June 1988 Plants have physical and chemical mechanisms for defense from attack by animals. Phytochemical defenses that protect plants from attack by insects include antifeedants, insecticides, and insect growth regulators. Phytochemical options exist by which plants ... Full text Open Access Link to item Cite

Monitoring of ovulation in the assessment of reproductive hazards in the workplace.

Journal Article Reprod Toxicol · 1988 If women are exposed to reproductive hazards in the workplace, some disturbances of ovulation are expected. Assessment of ovulation requires monitoring to distinguish normal and abnormal ovarian cycles. Menstrual interval and basal body temperature charts ... Full text Link to item Cite

Applications of hormone receptors in obstetrics and gynecology

Journal Article Adolescent and Pediatric Gynecology · 1988 Full text Cite

Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization.

Journal Article Fertil Steril · September 1987 In vitro fertilization and embryo transfer (IVF-ET) and gamete intrafallopian transfer (GIFT) are used to treat intractable infertility in women with no distortion of the pelvic viscera, despite the lack of controlled trials demonstrating efficacy. The mec ... Full text Link to item Cite

The effect of leuprolide acetate on ovulation induction with human menopausal gonadotropins in polycystic ovary syndrome.

Journal Article J Clin Endocrinol Metab · July 1987 The use of exogenous gonadotropins for treatment of clomiphene-resistant chronic anovulation in women with the polycystic ovary syndrome (PCO) is hazardous and often ineffective, possibly because of the abnormal endogenous gonadotropin secretion characteri ... Full text Link to item Cite

Treatment-independent, treatment-associated, and pregnancies after additional therapy in a program of in vitro fertilization and embryo transfer.

Journal Article Fertil Steril · April 1987 Although the technique of in vitro fertilization and embryo transfer (IVF-ET) was developed for couples with untreatable tubal factor infertility, IVF-ET is now being applied to women with other causes of infertility and normal pelvic anatomy. In an effort ... Full text Link to item Cite

Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro.

Journal Article Reprod Toxicol · 1987 We investigated the effects of a group of pharmaceutical agents commonly ingested by reproductive-aged women, acetaminophen and the nonsteroidal anti-inflammatory drugs (NSAID), on progesterone (P) production by cultures of highly differentiated porcine gr ... Full text Link to item Cite

Effects of phytoestrogens on GnRH-induced luteinizing hormone secretion in ovariectomized rats.

Journal Article Reprod Toxicol · 1987 Ovariectomized rats were pretreated with intravenous estradiol-17 beta (E2), coumestrol or genistein and were challenged 2 h later with GnRH (50 ng/kg BW, i.v.). Blood samples, drawn at the time of GnRH administration and 15 min afterwards, were assayed fo ... Full text Link to item Cite

Screening of potential reproductive toxicants by use of porcine granulosa cell cultures.

Journal Article Toxicology · April 2, 1984 While approximately 60 000 chemicals are in widespread use with 1000 new chemicals introduced into the environment each year, the biologic effects of these agents are poorly understood. With the specific goal of testing for potential reproductive toxicity, ... Full text Link to item Cite

Effects of (-)-trans- delta 9-tetrahydrocannabinol on serum prolactin in the pseudopregnant rat.

Journal Article Endocr Res Commun · 1982 Groups of pseudopregnant rats were injected intravenously with (-)-trans- delta 9-tetrahydrocannabinol (THC) to determine its effects on serum prolactin (PRL) and the maintenance of pseudopregnancy. A single injection of 4 mg THC/kg BW at 2400 h on the fir ... Full text Link to item Cite

Delta 9-tetrahydrocannabinol suppression of prolactin secretion in the rat: lack of direct pituitary effect.

Journal Article Endocrinology · September 1981 The effects of (--)trans-delta 9-tetrahydrocannabinol (THC) on tonic PRL secretion were investigated in long term ovariectomized or hypophysectomized/pituitary-autografted female rats and in flask incubations of anterior pituitary tissue. Intravenous injec ... Full text Link to item Cite

The function of the corpus luteum of pregnancy in ovulatory dysfunction and luteal phase deficiency.

Journal Article Fertil Steril · July 1981 Relatively little knowledge exists of corpus luteum function in early pregnancy after the successful treatment of ovulatory dysfunction or luteal phase deficiency. To assess the activity of the corpus luteum of such patients, human chorionic gonadotropin ( ... Full text Link to item Cite

Nausea and vomiting of pregnancy: role of human chorionic gonadotropin and 17-hydroxyprogesterone.

Journal Article Obstet Gynecol · June 1980 Although nausea and vomiting associated with early pregnancy are extremely common, the causal factors remain obscure. An endocrine etiology for this problem persists as a popular but unproved theory. The present study exn (hCG) and 17-hydroxyprogesterone ( ... Link to item Cite

Undergraduate research participation: A student's view

Journal Article Journal of Chemical Education · January 1, 1972 Full text Cite