Journal ArticleAm J Kidney Dis · January 2026
Skin disorders occur commonly in patients with chronic kidney disease (CKD) and may greatly impact their quality of life. These skin disorders have varying underlying pathophysiologies, but there are a few common mechanisms including the accumulation of ur ...
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Journal ArticleCurrent Dermatology Reports · December 1, 2025
Purposeof Review: Panniculitis presents a diagnostic challenge due to the diverse array of conditions that manifest with a similar clinical picture. Often, these diseases have ties to systemic issues and can be clues to underlying systemic ailments. This a ...
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Journal ArticleCurrent Infectious Disease Reports · December 1, 2025
Purpose of Review: Skin infections account for a substantial amount of healthcare visits within the pediatric population, contributing to significant healthcare costs and associated morbidity. We aim to describe the most common infections with a focus on r ...
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Journal ArticleCurrent Dermatology Reports · December 1, 2025
Purpose of Review: An effective transition from inpatient to outpatient care is pivotal in ensuring successful recovery following hospitalization and preventing readmission. This review discusses potential discharge pitfalls for patients with skin disease ...
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Journal ArticlePediatr Dermatol · November 20, 2025
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis in infancy, often misdiagnosed due to overlap with infectious and inflammatory conditions. We review existing literature on neonatal and infantile PG and present a case of a previously healthy 6-m ...
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Journal ArticleJ Am Acad Dermatol · October 2025
BACKGROUND: Current understanding of calciphylaxis pathogenesis and treatment has advanced, with lower mortality. OBJECTIVE: To provide an updated report of calciphylaxis risk factors and outcomes in a large and diverse multicenter American validated cohor ...
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Journal ArticleAm J Clin Dermatol · July 2025
Cellulitis, a bacterial skin infection most frequently caused by group A streptococci (Streptococcus pyogenes) and less so by Staphylococcus aureus, commonly occurs in pediatric patients. The non-specific clinical presentation of poorly demarcated, expandi ...
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Journal ArticleJ Am Acad Dermatol · November 2024
BACKGROUND: Calciphylaxis patients historically have experienced diagnostic challenges and high morbidity; however limited data is available examining these characteristics over time. OBJECTIVE: The primary goals were to a) investigate factors associated w ...
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Journal ArticleInt J Gynaecol Obstet · August 2024
The aim of this review is to increase obstetrician awareness of pregnancy-associated Sweet syndrome. Patients present with fever, leukocytosis, and skin eruption, which can mimic other infectious or inflammatory conditions, but do not respond to antibiotic ...
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Journal ArticleCutis · June 2024
Inpatient hospitalization of individuals with hidradenitis suppurativa (HS) has increased. Inpatient services may not be familiar enough with this disease to understand how to manage severe HS and/or HS flares. It would be beneficial to the inpatient medic ...
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Journal ArticleJ Allergy Clin Immunol Pract · May 2024
When approaching a case of apparent drug allergy, the consulting clinician should consider a broad differential diagnosis. This article presents a series of cases that could be commonly referred to an allergist for assessment as "drug allergy," however, a ...
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Journal ArticleJ Immunother Cancer · April 10, 2024
With an increasing number of patients eligible for immune checkpoint inhibitors, the incidence of immune-related adverse events (irAEs) is on the rise. Dermatologic immune-related adverse events (D-irAEs) are the most common and earliest to manifest, often ...
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ConferenceJ Am Acad Dermatol · January 2024
BACKGROUND: Calciphylaxis is a thrombotic vasculopathy characterized by painful necrotic ulcerations. There are no Food and Drug Administration approved therapies despite high mortality. OBJECTIVE: To compare mortality and wound healing outcomes in patient ...
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Chapter · January 1, 2024
Cutaneous deposition of calcium has a range of manifestations, from mild to fatal, and a number of etiologies. It is categorized as dystrophic if calcium deposits within pre-existing damaged skin, metastatic if it results from a calcium and/or phosphate im ...
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Journal ArticleJ Pediatr · November 2023
OBJECTIVE: To assess cellulitis in the neonatal intensive care unit (NICU) setting and identify risk factors for its disease severity and whether cellulitis influences length of stay (LOS). STUDY DESIGN: In this retrospective study, patients with celluliti ...
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Journal ArticleBurns Open · October 1, 2023
Epidermolysis bullosa acquisita is a rare mucocutaneous autoimmune blistering disorder which usually presents in adulthood. The disease is mediated by antibodies against type VII collagen, though the precise inciting factors for autoantibody formation are ...
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Journal ArticleCurrent Dermatology Reports · September 1, 2023
Purpose of Review: Necrotizing neutrophilic dermatoses are frequently misdiagnosed as necrotizing fasciitis, resulting in inappropriate surgical intervention and amputation leading to unnecessary morbidity. This paper reviews recent literature to highlight ...
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Journal ArticleJAMA Dermatol · July 1, 2023
IMPORTANCE: Scoring systems for Stevens-Johnson syndrome and epidermal necrolysis (EN) only estimate patient prognosis and are weighted toward comorbidities and systemic features; morphologic terminology for EN lesions is inconsistent. OBJECTIVES: To estab ...
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Journal ArticleJAMA Netw Open · April 3, 2023
IMPORTANCE: Calciphylaxis is a rare disease with high mortality mainly involving patients with chronic kidney disease (CKD). Sodium thiosulphate (STS) has been used as an off-label therapeutic in calciphylaxis, but there is a lack of clinical trials and st ...
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Journal ArticleEmerg Infect Dis · April 2023
We describe a case of mpox characterized by a circularly distributed facial rash but no identified risk factors. Fomite transmission of monkeypox virus from contaminated linen at a massage spa was suspected. Clinicians should consider mpox in patients with ...
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Journal ArticleNephrol Dial Transplant · February 28, 2023
BACKGROUND: Vascular calcification (VC) is a common comorbidity among patients with chronic kidney disease (CKD), indicating major cardiovascular events. This study aimed to evaluate the effects and safety of intravenous sodium thiosulphate (STS) for VC in ...
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Journal ArticleMayo Clinic Proceedings Innovations Quality and Outcomes · February 1, 2023
Objective: To describe the pain intensity among hospitalized patients with calciphylaxis, elucidate the factors associated with pain improvement, and examine the link between pain improvement and clinical outcomes. Patients and Methods: Patients were ident ...
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Journal ArticlePediatr Dermatol · 2023
Isotretinoin is a systemic therapy approved for acne and has historically required lab monitoring in addition to adherence to the iPLEDGE Risk Evaluation and Mitigation Strategy (REMS) given the medication's teratogenic effects. The COVID-19 pandemic resul ...
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Journal ArticleFrontiers in Medicine · January 1, 2023
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a predominantly drug-induced disease, with a mortality rate of 15–20%, that engages the expertise of multiple disciplines: dermatology, allergy, immunology, clinical pharmacology, burn surger ...
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Chapter · January 1, 2023
Macular, papular, purpuric, vesiculobullous, and pustular diseases include exanthems, toxin-mediated diseases, primary skin infections, vasculitis, embolic phenomena, thrombotic sequelae, autoimmune blistering diseases, and hypersensitivity reactions. By u ...
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Journal ArticlePediatr Dermatol · November 2022
The emergency department (ED) is a frequent source of care for pediatric patients with dermatologic conditions, possibly owing to limited access to routine and urgent outpatient dermatology appointments. The demographics, clinical characteristics, follow-u ...
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Journal ArticleCutis · September 2022
Cellulitis is an infection of the skin and skin-associated structures with many clinical mimickers known collectively as pseudocellulitis. Dermatology or infectious disease consultation is considered the gold standard for diagnosis. We evaluated a prospect ...
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Journal ArticleCurrent Dermatology Reports · September 1, 2022
Purpose of Review: This article reviews the pathophysiology, clinical presentation, clinical mimickers, and management strategies for cellulitis in hospitalized patients. Recent Findings: Cellulitis is a common skin infection with increasing hospitalizatio ...
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Journal ArticleGenet Med · September 2022
PURPOSE: Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are genetically distinct tumor predisposition syndromes with overlapping phenotypes. We sought to update the diagnostic criteria for NF2 and SWN by incorporating recent advances in genetics, ...
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Journal ArticlePediatr Dermatol · July 2022
The clinical features of 588 pediatric inpatients admitted with a diagnosis of cellulitis were reviewed with attention to diagnostic accuracy of true cellulitis (95.1%) versus pseudocellulitis (4.9%) and utilization of specialist consultations (28.1% infec ...
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Journal ArticleJ Am Acad Dermatol · May 2022
Calciphylaxis is an uncommon but devastating disorder characterized by vascular calcification and subsequent cutaneous tissue necrosis. This results in exquisitely painful and slow healing wounds that portend exceptionally high morbidity and mortality. The ...
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Journal ArticleJ Am Acad Dermatol · May 2022
Calciphylaxis is a rare and devastating condition with important systemic ramifications. This second-part of our CME aims to educate the practicing dermatologist on the current standard of care once a diagnosis of calciphylaxis is confirmed or highly suspe ...
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Journal ArticleAliment Pharmacol Ther · May 2022
BACKGROUND AND AIMS: Extra-intestinal manifestations (EIMs) are a common complication of inflammatory bowel diseases (IBD), affecting up to half of the patients. Despite their high prevalence, information on standardised definitions, diagnostic strategies, ...
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Journal ArticleJ Cutan Pathol · December 2021
BACKGROUND: Symmetric drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous drug reaction characterized by gluteal/anogenital erythema and symmetric involvement of other intertriginous location(s) without systemic signs. Clinicopatholo ...
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Journal ArticleJ Am Acad Dermatol · December 2021
BACKGROUND: Calciphylaxis is an ischemic vasculopathy with high morbidity and mortality. Early and accurate diagnosis is critical to management of calciphylaxis. Clinical mimickers may contribute to delayed or misdiagnosis. OBJECTIVE: To assess the rate an ...
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Journal ArticleJ Am Acad Dermatol · November 2021
BACKGROUND: Calciphylaxis is a rare disorder characterized by skin necrosis caused by calcium deposition within vessels, thrombosis, and subsequent tissue ischemia. Penile involvement may rarely occur. OBJECTIVE: To identify risk factors, diagnosis, manage ...
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Journal ArticleJ Am Acad Dermatol · October 2021
BACKGROUND: Calciphylaxis is a rare thrombotic vasculopathy characterized by high morbidity and mortality. There is a paucity of studies examining longitudinal outcomes. OBJECTIVE: To assess mortality, days spent in the hospital, and amputations in patient ...
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Journal ArticlePediatr Dermatol · September 2021
BACKGROUND: Although dermatologic complaints are frequently encountered by pediatricians, access to pediatric dermatologists remains limited. Teledermatology has been proposed to expand access to dermatologic care for children. We report our experience wit ...
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Journal ArticleJ Am Acad Dermatol · September 2021
BACKGROUND: Biologic agents may predispose patients to skin and soft tissue infections (SSTIs). Guidelines recommend discontinuing the agent preoperatively; the true risk of infection is unclear. OBJECTIVES: To assess the incidence of SSTIs in patients rec ...
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Journal ArticleJ Am Acad Dermatol · September 2021
BACKGROUND: The yield of skin biopsies in the evaluation of intravascular lymphoma (IVL) is largely unknown in Western patients. Most data supporting this test come from Asian populations, in which both prevalence and disease presentation seem to differ. O ...
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Journal ArticleArch Dermatol Res · September 2021
Clinicians play a critical role in recognizing, initiating, and adopting innovative solutions to clinical problems. Increasing clinician involvement in problem-based innovation will help identify and solve unmet medical needs. The overall objective of our ...
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Journal ArticleJid Innovations · September 1, 2021
Cellulitis is frequently misdiagnosed owing to its clinical mimickers, collectively known as pseudocellulitis. This study investigated diffuse reflectance spectroscopy (DRS) alone and in combination with infrared thermography (IRT) for the differentiation ...
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Journal ArticleGenet Med · August 2021
PURPOSE: By incorporating major developments in genetics, ophthalmology, dermatology, and neuroimaging, to revise the diagnostic criteria for neurofibromatosis type 1 (NF1) and to establish diagnostic criteria for Legius syndrome (LGSS). METHODS: We used a ...
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Journal ArticleAm J Dermatopathol · July 1, 2021
Cutaneous reactions surrounding abdominal stoma sites are typically irritant, allergic, infectious, traumatic or pathergic in etiology. Pemphigus, which encompasses a group of vesiculobullous autoimmune skin disorders, is seldom encountered as a peristomal ...
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Journal ArticleMed Clin North Am · July 2021
Cellulitis is a common skin infection resulting in increasing hospitalizations and health care costs. There is no gold standard diagnostic test, making cellulitis a potentially challenging condition to distinguish from other mimickers. Physical examination ...
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Journal ArticlePediatr Dermatol · July 2021
The rapid rise of telemedicine during the COVID-19 pandemic raised the prospect of worsening health care disparities for vulnerable populations. We retrospectively compared pediatric teledermatology visits scheduled during the pandemic (03/17/2020-07/31/20 ...
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Journal ArticleJAMA Dermatol · June 1, 2021
IMPORTANCE: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is known to cause multiple end-organ complications in its acute phase, but less is known about the long-term association with patients' mental health and quality of life. OBJECTIVE: ...
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Journal ArticleJ Am Acad Dermatol · June 2021
BACKGROUND: Patient outcomes are improved when dermatologists provide inpatient consultations. Inpatient access to dermatologists is limited, illustrating an opportunity to use teledermatology. Little is known about the ability of dermatologists to accurat ...
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Journal ArticleJ Am Acad Dermatol · February 2021
Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the United States population. This guideline addresses important clinical questions that arise in psoriasis management and care and provides recommendations based on the a ...
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Journal ArticlePediatr Dermatol · September 2020
BACKGROUND/OBJECTIVES: Store-and-forward teledermatology provides pediatricians with specialist guidance in managing skin disease. This study evaluates wait times and face-to-face (FTF) dermatology visit avoidance associated with a pediatric dermatology eC ...
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Journal ArticleJ Am Acad Dermatol · June 2020
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions with high morbidity and mortality. Supportive care management of SJS/TEN is highly variable. A systematic review of the literature was performed by dermatol ...
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Journal ArticleJ Am Acad Dermatol · June 2020
Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world's population. In this guideline, we focus the discussion on systemic, nonbiologic medications for the treatment of this disease. We pro ...
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Journal ArticleJAMA Dermatol · June 1, 2020
This retrospective case-control study of 26 adults evaluates the use of cyclosporine A in the treatment of drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) compared with standard systemic glucocorticosteroids. ...
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Journal ArticleJ Am Acad Dermatol · June 2020
BACKGROUND: Renal involvement in adult Henoch-Schönlein purpura is a major cause of morbidity and can lead to significant long-term renal impairment. The prognostic significance of normal or minimal urinary abnormalities at diagnosis is unknown. OBJECTIVE: ...
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Journal ArticlePediatr Dermatol · May 2020
Little guidance on management of basal cell nevus syndrome in children exists. We report a case series of four patients diagnosed with BCNS in early childhood, in whom several highly suspicious lesions were biopsied, but several smaller and questionably co ...
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Journal ArticleJ Am Acad Dermatol · January 2020
Psoriasis is a chronic, multisystem, inflammatory disease that affects approximately 1% of children, with onset most common during adolescence. This guideline addresses important clinical questions that arise in psoriasis management and provides evidence-b ...
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Chapter · January 1, 2020
As major advancements in cancer treatment are being made, adverse effects including cutaneous ones are increased in parallel. The cutaneous adverse events result in declined quality of life as well as increased cost of health care. Awareness of the spectru ...
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Journal ArticleJ Am Acad Dermatol · December 2019
BACKGROUND: Cellulitis has many potential mimickers, and its misdiagnosis often leads to unnecessary hospitalizations and higher health care costs. The ALT-70 predictive model offers an objective tool to help differentiate between cellulitis and other clin ...
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Journal ArticleJ Am Acad Dermatol · September 2019
Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 3.2% of the world's population. In this section of the guidelines of care for psoriasis, we will focus the discussion on ultraviolet (UV) light-based t ...
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Journal ArticleJ Pediatr Surg · July 2019
PURPOSE: Carmi syndrome is a rare genetic disorder characterized by junctional epidermolysis bullosa (JEB) and pyloric atresia (PA). We reviewed the clinicopathologic and molecular features of patients with Carmi syndrome to identify predictors of clinical ...
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Journal ArticleJAMA Dermatol · April 1, 2019
IMPORTANCE: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a spectrum of severe mucocutaneous drug reaction associated with significant morbidity and mortality. A previously developed SJS/TEN-specific severity-of-illness model (Score of T ...
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Journal ArticleJ Am Acad Dermatol · April 2019
Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available e ...
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Journal ArticleJ Am Acad Dermatol · April 2019
Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations based on the available evide ...
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Journal ArticleDermatopathology (Basel) · 2019
Cutaneous reactions are among the most prevalent immune-related adverse events in patients treated with immunotherapy. Given that immunotherapies often act through blocking inhibitory signals on T cells, these treatments also have the potential to generate ...
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Journal ArticlePLoS One · 2019
Calciphylaxis is a rare and life-threatening disease that classically manifests with painful skin lesions. It occurs mainly in patients with end-stage renal disease (ESRD) treated with dialysis, has poor outcomes, and has no FDA-approved treatment. Our coh ...
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Journal ArticleDermatopathology (Basel) · 2019
A 69-year-old Vietnamese female presented with fever and new-onset tender subcutaneous nodules on her trunk and lower extremities initially thought to be clinically consistent with erythema nodosum. A biopsy showed an atypical, predominantly lobular lympho ...
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Journal ArticleDermatopathology (Basel) · 2019
Tumid lupus is a rare subtype of chronic cutaneous lupus that is characterized by urticaria-like photosensitive plaques. Unlike discoid lupus, it has minimal to no surface change and resolves without scarring. On pathological examination, it may be disting ...
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Journal ArticleDermatopathology (Basel) · 2019
Leukocytoclastic vasculitis (LCV) is a small-vessel vasculitis that most commonly affects the postcapillary venules in the skin. It classically presents with purpuric macules that progress to palpable purpura on the bilateral shins 7-10 days after an incit ...
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Journal ArticleDermatopathology (Basel) · 2019
Mycosis fungoides, the most common cutaneous T-cell lymphoma, is known to exhibit varied clinical presentations and mimic many other dermatoses. This morphological heterogeneity can often lead to initial misdiagnoses resulting in significant delays from sy ...
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Journal ArticleDermatopathology (Basel) · 2019
Hyperkeratotic Kaposi's sarcoma (KS) is a rare clinicopathologic variant of AIDS-related KS that typically presents with chronic lymphedema and diffuse hyperkeratotic plaques of the lower extremities. Histopathologically, this variant is defined by epiderm ...
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Journal ArticleCutis · December 2018
Calciphylaxis is a rare painful skin condition classically seen in patients with end-stage renal disease (ESRD), particularly those on chronic dialysis; however, it also has been increasingly reported in patients with normal renal function. Calciphylaxis i ...
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Journal ArticleJ Invest Dermatol · November 2018
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 ...
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Journal ArticleClin Case Rep · September 2018
Diffuse cutaneous mastocytosis (DCM) is a rare but potentially fatal condition when diagnosis and targeted treatments are delayed. This case illustrates the life-threatening complications in DCM and reviews the currently available treatments. To our knowle ...
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Journal ArticleMayo Clin Proc · September 2018
OBJECTIVE: To define concomitant risk factors, treatment, and outcomes for patients with nonnephrogenic calciphylaxis (NNC). PATIENTS AND METHODS: A retrospective review of Massachusetts General Hospital (MGH) medical records (January 1, 2014, through Febr ...
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Journal ArticleJAMA Intern Med · July 1, 2018
This cohort study examines the clinical usefulness and cost of blood cultures and imaging in patients with presumed cellulitis. ...
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Journal ArticleJAMA Dermatol · May 1, 2018
IMPORTANCE: Each year, cellulitis leads to 650 000 hospital admissions and is estimated to cost $3.7 billion in the United States. Previous literature has demonstrated a high misdiagnosis rate for cellulitis, which results in unnecessary antibiotic use and ...
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Journal ArticleInt J Dermatol · May 2018
BACKGROUND: Although considered an outpatient specialty, dermatology plays an important role in inpatient medicine. We characterized the activity and structure of dermatology consultation services in select U.S. hospitals. METHODS: In this cross sectional ...
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Journal ArticleJ Am Acad Dermatol · April 2018
BACKGROUND: Recurrent cellulitis is diagnosed in 22% to 49% of all cellulitis cases, but little is known about the costs associated with these cases. OBJECTIVE: To characterize patients with recurrent cellulitis in the outpatient setting and estimate the a ...
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Journal ArticleJ Invest Dermatol · March 2018
Warmth is a characteristic but nondiagnostic feature of cellulitis. We assessed the diagnostic utility of skin surface temperature in differentiating cellulitis from pseudocellulitis. Adult patients presenting to the emergency department of a large urban h ...
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Journal ArticleContact Dermatitis · March 2018
BACKGROUND: The use of metal-containing bio-devices is becoming increasingly common. Self-reported history of dermatitis with metal exposure is not established as being predictive for metal allergy. OBJECTIVES: To assess the validity of two screening quest ...
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Journal ArticleJAMA Dermatol · February 1, 2018
IMPORTANCE: Calciphylaxis is a rare skin disease with high morbidity and mortality that frequently affects patients with renal disease. Hypercoagulable conditions are frequently observed in both patients with calciphylaxis and those with chronic kidney dis ...
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Journal ArticleJ Pediatr · February 2018
We report a case of nonfatal junctional epidermolysis bullosa and pyloric atresia in a newborn. We identified a substitution (c.914C>T) for the integrin β4 gene that has been associated with favorable outcome. A novel mutation (c.2011T>G) of unknown signif ...
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Journal ArticleJ Cutan Pathol · February 2018
ALK rearrangements occur in up to 10% of spitzoid melanocytic neoplasms. No reported cases have shown homozygous deletion of 9p21 (CDKN2A) or gains of 6p25 (RREB1) or 11q13 (CCND1), which have been associated with aggressive clinical behavior. Here we repo ...
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Journal ArticleAm J Nephrol · 2018
Calciphylaxis is a disease of dermal arteriolar calcification that results in necrosis. It commonly occurs in individuals with end-stage renal disease (ESRD) on hemodialysis and is associated with a high morbidity and mortality. Warfarin use is an identifi ...
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Journal ArticleJ Am Acad Dermatol · January 2018
BACKGROUND: Henoch-Schönlein purpura (HSP) is a small vessel IgA-predominant vasculitis. OBJECTIVE: To describe adult patients with HSP and determine if the distribution of skin lesions (ie, purpura above the waist or purpura below the waist only), is a pr ...
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Journal ArticleClin Exp Dermatol · January 2018
BACKGROUND: Therapeutics targeting tumour necrosis factor (TNF)-α are effective for psoriasis; however, in patients treated for other disorders, psoriasis may worsen and psoriasiform dermatitis (PsoD) may arise. T helper (Th) cytokines in psoriasis upregul ...
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Journal ArticleDermatopathology (Basel) · 2018
Patients who present with papular rashes have a wide differential diagnosis particularly in the setting of immune compromise. A 30-year-old male diagnosed with HIV since 2009, never on antiretroviral therapy, with a nadir CD4 count of 333 cells/mm3 and a c ...
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Journal ArticleDermatopathology (Basel) · 2018
Churg-Strauss syndrome or eosinophilic granulomatosis with polyangiitis is a systemic vasculitis affecting the small and medium-sized vasculature. It is commonly associated with asthma and eosinophilia. Most patients are diagnosed at around the age of 40. ...
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Journal ArticlePediatr Dermatol · September 2017
BACKGROUND/OBJECTIVES: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are medical emergencies. Mainstays of treatment include removal of the offending agent, supportive care, and wound care. The use of immunosuppressive agents such as ...
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Journal ArticleJ Drugs Dermatol · July 1, 2017
BACKGROUND: Treatment of vitiligo is aimed at repigmentation and often consists of multiple modalities, none of which are universally or rapidly successful. Extensive cases are most often treated with ultraviolet light therapy, which can be both costly ...
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Journal ArticleAm J Clin Dermatol · June 2017
Immune disorders are associated with acne or acneiform lesions secondary to the occurrence of acne vulgaris or acneiform eruptions arising as a result of immunosuppressive medication or infection. In this review, we aim to provide an overview of acne and a ...
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Journal ArticleHernia · June 2017
INTRODUCTION: Delayed type IV hypersensitivity reactions are well established in the surgical setting with respect to external exposure via topical antibiotics and internal exposure via synthetic materials. In contrast, biologic matrix is derived from dece ...
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Journal ArticleJ Am Acad Dermatol · April 2017
BACKGROUND: Cellulitis has many clinical mimickers (pseudocellulitis), which leads to frequent misdiagnosis. OBJECTIVE: To create a model for predicting the likelihood of lower extremity cellulitis. METHODS: A cross-sectional review was performed of all pa ...
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Journal ArticleJAMA Dermatol · February 1, 2017
IMPORTANCE: Inflammatory dermatoses of the lower extremity are often misdiagnosed as cellulitis (aka "pseudocellulitis") and treated with antibiotics and/or hospitalization. There is limited data on the cost and complications from misdiagnosed cellulitis. ...
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Journal ArticleAm J Dermatopathol · February 2017
Over the past decade, numerous targeted therapeutic agents have become available for clinical use in the oncologic setting with the hopes of realizing personalized cancer treatment. These agents have achieved great improvements in clinical outcomes for pat ...
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Journal ArticlePediatr Dermatol · January 2017
Alopecia areata (AA) involves the immune-related destruction of hair follicles, resulting in patches of complete hair loss, most often on the scalp. The topical sensitizer squaric acid dibutylester (SADBE) is a popular treatment option given its low side-e ...
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Journal ArticleJAMA · July 19, 2016
IMPORTANCE: Cellulitis is an infection of the deep dermis and subcutaneous tissue, presenting with expanding erythema, warmth, tenderness, and swelling. Cellulitis is a common global health burden, with more than 650,000 admissions per year in the United S ...
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Journal ArticleAliment Pharmacol Ther · March 2016
BACKGROUND: Anti-tumour necrosis factor (anti-TNF) biologic associated psoriasis has been reported in inflammatory bowel disease (IBD) patients. However, little is known regarding its pathogenesis. AIM: To identify potential genetic predispositions to anti ...
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Journal ArticleInt J Dermatol · February 2016
BACKGROUND: The diagnosis of Lyme disease relies on the accurate diagnosis of erythema chronicum migrans (ECM) because serologic tests, culture, and polymerase chain reactions are often inaccurate. Although ECM is classically associated with a targetoid ra ...
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Journal ArticleJ Am Acad Dermatol · September 2015
BACKGROUND: Topical immunotherapy using potent contact allergens, such as squaric acid dibutylester (SADBE), can be used to treat alopecia areata. However, there are conflicting reports regarding the best protocol for its administration, particularly with ...
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Chapter · August 21, 2015
Acute generalized exanthematous pustulosis (AGEP) is an acute, selflimited, widespread cutaneous eruption characterized by the development of numerous, Non-Follicular, sterile pustules on a background of erythematous, edematous skin. The eruption usually d ...
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Journal ArticleJ Am Acad Dermatol · July 2015
BACKGROUND: Given its nonspecific physical examination findings, accurately distinguishing cellulitis from a cellulitis mimicker (pseudocellulitis) is challenging. OBJECTIVE: We sought to investigate the national incidence of cellulitis misdiagnosis among ...
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Journal ArticleJAMA Dermatol · July 2015
IMPORTANCE: Psoriasis and atopic dermatitis (AD) are inflammatory diseases thought to be mediated by helper T-cell subtypes 1 and 2 (TH1 and TH2), respectively. Although psoriasis and AD show histopathologic differences during chronic disease, they are dif ...
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Journal ArticleAm J Kidney Dis · July 2015
Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in patients with chronic kidney failure treated wit ...
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ConferencePediatr Dermatol · 2015
Congenital dermal melanocytosis (CDM) is a birthmark composed of macular blue-grey hyperpigmentation commonly observed in the lumbosacral region of infants. Generally resolving by childhood, it is traditionally considered a benign condition, but it may be ...
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Chapter · January 1, 2015
Calcinosis cutis, or insoluble calcium salt deposition in the skin and subcutaneous tissue, results from local or systemic insults which disturb the factors regulating calcium. The condition is classified into four subtypes based on the presumed mechanism ...
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Journal ArticlePediatr Dermatol · 2015
Condylomata acuminata (CA), or anogenital warts, are typically benign lesions caused by human papillomavirus infection. Although they are rare, immunocompromised individuals are at a higher risk of CA undergoing transformation into invasive anal squamous c ...
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Journal ArticlePediatr Dermatol · 2015
Eczematid-like purpura of Doucas and Kapetanakis is a subtype of the pigmented purpuric dermatoses, a group of uncommon dermatoses of unclear etiology characterized by purpura, petechiae, and hyperpigmentation. The Doucas and Kapetanakis subtype is rare in ...
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Journal ArticleConsultant · January 1, 2015
Since prompt identification and treatment of cellulitis is critical, primary care physicians should be familiar with the condition and know when to reach out to a specialist for assessment to provide the patient with the most effective and cost-efficient t ...
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Journal ArticleJ Cutan Pathol · January 2015
BACKGROUND: Pseudolymphomatous folliculitis is a lymphoid proliferation that clinically and histopathologically mimics primary cutaneous extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In this study, we assessed the ...
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Chapter · January 1, 2015
Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (CD8+ AECTCL) is a rare, aggressive cutaneous T-cell lymphoma with a poor prognosis. Although CD8+ AECTCL typically initially presents on the skin, visceral dissemination is common. ...
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Journal ArticleDermatol Online J · December 14, 2014
Pemphigus vulgaris is an uncommon intraepidermal blistering disorder that typically presents with flaccid bullae or erosions. We report a patient with pemphigus vulgaris who presented with several unusual clinical features: tense bullae with dependently la ...
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Journal ArticleJ Am Acad Dermatol · December 2014
BACKGROUND: The management of dysplastic nevi (DN) is a highly debated and controversial topic within the dermatology community. Clinicians agree that margin-positive severely DN should be removed with a surgical margin, however, there is disagreement surr ...
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Journal ArticleJAMA Dermatol · October 2014
IMPORTANCE: Cellulitis is a common and costly problem, often diagnosed in the outpatient setting. Many cutaneous conditions may clinically mimic cellulitis, but little research has been done to assess the magnitude of the problem. OBJECTIVE: To determine i ...
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Chapter · August 19, 2014
Prepared by residents and attending physicians, this pocket-sized loose-leaf is created in the style of Pocket Medicine by providing key clinical data for students and residents and focuses on patient care in the ob/gyn setting. ...
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Journal ArticleJAMA Dermatol · July 2014
IMPORTANCE: Telaprevir, combined with pegylated interferon alfa and ribavirin, is an efficacious approach to treat hepatitis C virus infection. A morbilliform eruption associated with telaprevir is a common adverse effect experienced by patients. Current g ...
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Journal ArticlePediatr Dermatol · 2014
A number of lesions have been documented to arise within congenital melanocytic nevi (CMNs). Although the most frequent malignancy arising within a CMN is melanoma, the association between rhabdomyosarcoma and CMN has rarely been documented. We present a c ...
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Journal ArticlePediatr Dermatol · 2014
Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering disorder that occurs infrequently in children. Although typically associated with a good prognosis in children, there are rare cases that are refractory to treatment with conventional immuno ...
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Journal ArticleJ Am Acad Dermatol · December 2013
BACKGROUND: Levamisole is present as a contaminant or additive in most cocaine sold in the United States. Cases of agranulocytosis attributed to levamisole-tainted cocaine have been widely described. A vasculopathic reaction to levamisole has also been rep ...
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Journal ArticleJAMA Dermatol · August 2013
IMPORTANCE: Calciphylaxis is a potentially fatal disorder of abnormal calcium deposition. Patients commonly present with painful retiform to stellate purpuric lesions that often undergo ulceration and necrosis, increasing the risk of infection and life-thr ...
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Journal ArticleAm J Dermatopathol · July 2013
Calciphylaxis is a rare and life-threatening disease characterized by cutaneous necrosis and vascular calcification. Often, skin biopsy specimens are not diagnostic because of the limited depth of the specimen, biopsy site, and clinical stage. To better un ...
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Journal ArticleJ Am Acad Dermatol · January 2013
BACKGROUND: Dermatologists provide the bulk of psychocutaneous care; however, recent studies suggest that dermatologists believe they are largely underprepared to treat most psychocutaneous conditions. OBJECTIVE: We sought to identify gaps in psychodermato ...
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Journal ArticleJ Am Acad Dermatol · November 2012
BACKGROUND: We report a series of patients initially given the diagnosis of necrotizing fasciitis whose course progressed despite surgical debridement, antibiotic therapy, or both, but who responded rapidly to systemic corticosteroids. OBJECTIVE: We sought ...
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Journal ArticleJ Pediatr · November 2012
We report the case of a 31-day-old girl presenting with severe respiratory distress and cutaneous lesions from Sweet syndrome. Pulmonary symptoms unresponsive to antibiotics in patients with Sweet syndrome should raise suspicion for neutrophilic infiltrati ...
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Journal ArticleAm J Dermatopathol · October 2012
In the last 2 decades the introduction new biologic agents such as tumor necrosis factor alpha inhibitors has resulted in potent disease modifying effects in a variety of immune-mediated diseases. In addition, there were major advancements in cancer treatm ...
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Journal ArticleJ Am Acad Dermatol · May 2012
BACKGROUND: The main morbidity associated with Henoch-Schonlein purpura (HSP) results from glomerulonephritis and associated renal symptoms; thus early and accurate diagnosis would have follow-up implications. OBJECTIVE: To determine the strength of associ ...
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Journal ArticleAliment Pharmacol Ther · December 2011
BACKGROUND Anti-tumour necrosis factor (TNF) antibodies are used to treat both psoriasis and inflammatory bowel disease. The seemingly paradoxical occurrence of psoriasis in patients treated with anti-TNF antibodies is increasingly recognised, but the dis ...
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Journal ArticleAm J Med Genet A · September 2011
Sotos syndrome is a well-described multiple anomaly syndrome characterized by overgrowth, distinctive craniofacial appearance, and variable learning disabilities. The diagnosis of Sotos syndrome relied solely on these clinical criteria until haploinsuffici ...
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Chapter · January 1, 2011
Acne is one of the most common skin infections, affecting approximately 85% of people at some point during their lives. The lesions consist of open and closed comedones (blackheads and whiteheads), papules, pustules, cysts, and/or nodules over the face, ch ...
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Journal ArticleDermatol Ther · 2011
Cellulitis is an acute infection of the dermal and subcutaneous layers of the skin, often occurring after a local skin trauma. It is a common diagnosis in both inpatient and outpatient dermatology, as well as in the primary care setting. Cellulitis classic ...
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Journal ArticleClin Dermatol · 2011
Iatrogenic skin injuries in hospitalized patients range from drug-related complications to those related to procedures. Common drug complications include drug reaction with eosinophilia and systemic symptoms (DRESS), linear immunoglobulin (Ig) A bullous de ...
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Journal ArticleJ Drugs Dermatol · January 2011
Herpes zoster is a skin disease encountered commonly in dermatologic practice. While post-herpetic neuralgia (PHN) is a familiar side effect of this condition, it is not the only neuropathic symptom that can result. Post-herpetic itch (PHI) is less well kn ...
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Journal ArticleSex Transm Dis · August 2009
BACKGROUND: Lues maligna (also known as malignant syphilis or ulceronodular syphilis) is a rare dermatologic manifestation of syphilis more commonly seen in patients with HIV infection. The classic lesion of lues maligna is an oval, papulopustular skin les ...
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Chapter · January 1, 2009
Bacterial infections represent the major cause of morbidity in patients undergoing solid organ transplantation (SOT). Soft tissue infections from bacteria generally occur in the first month after transplantation when the skin is disrupted by the surgery it ...
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Journal ArticleSemin Cutan Med Surg · September 2007
Dermatologists frequently are consulted in the evaluation and management of the patient with cellulitic-appearing skin. For routine cellulitis, the clinical presentation and patient symptoms are usually sufficient for an accurate diagnosis. However, when t ...
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Chapter · January 1, 2007
Topical retinoids are singularly important agents in the treatment of acne vulgaris. Any molecule having a biological effect through the binding and activation of retinoid receptors is considered a retinoid (1). This class of medications includes vitamin A ...
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Journal ArticleExpert Review of Dermatology · October 1, 2006
With the increased understanding and application of molecular genetics, exceptions to Mendelian genetics have been characterized. Uniparental disomy and genomic imprinting are two genetic mechanisms that often underlie these unusual patterns of inheritance ...
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Journal ArticleDermatol Ther · 2006
Rosacea is a condition most commonly associated with adults; however, various forms exist in the pediatric population and need to be considered when a child presents with a facial rash. Acne rosacea, steroid rosacea, granulomatous periorificial dermatitis, ...
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