David Keith Walmer

Adjunct Professor of Global Health

Duke Global Health Institute

310 Trent Drive, Box 90517, Durham, NC 27708

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2. Previous Appointments & Affiliations

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1. Global Scholarship

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1. Selected Grants

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1. Selected Publications

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Selected Publications

Improving IVF Utilization with Patient-Centric Artificial Intelligence-Machine Learning (AI/ML): A Retrospective Multicenter Experience.

Journal Article Journal of clinical medicine · June 2024 Objectives: In vitro fertilization (IVF) has the potential to give babies to millions more people globally, yet it continues to be underutilized. We established a globally applicable and locally adaptable IVF prognostics report and framework to supp ... Full text Cite

Perceived Feasibility, Acceptability, and Cultural Adaptation for a Mental Health Intervention in Rural Haiti.

Journal Article Culture, medicine and psychiatry · March 2020 Mental healthcare is largely unavailable throughout Haiti, particularly in rural areas. The aim of the current study is to explore perceived feasibility, acceptability, and effectiveness of potential culturally adapted interventions to improve mental healt ... Full text Cite

Prevalence of hypertension and peripheral arterial disease in adults in Léogâne, Haiti

Journal Article Journal of Global Health Reports · May 1, 2019 Full text Open Access Cite

Head and Neck Cancer in Haiti: A Case Series from Hopital de L'Universite d'Etat d'Haiti.

Journal Article International journal of otolaryngology · January 2018 This manuscript characterizes the demographics, presenting symptoms and risk factors of patients diagnosed with head and neck cancer at Hopital de L'Universite d'Etat d'Haiti (HUEH), Haiti's single largest healthcare facility. We conducted a prospective st ... Full text Open Access Cite

The socioeconomic impact of international aid: a qualitative study of healthcare recovery in post-earthquake Haiti and implications for future disaster relief.

Journal Article Global public health · May 2017 We assessed healthcare provider perspectives of international aid four years after the Haiti Earthquake to better understand the impact of aid on the Haitian healthcare system and learn best practices for recovery in future disaster contexts. We conducted ... Full text Cite

Otorhinolaryngology/Head and Neck Surgery in a low income country: The Haitian experience.

Journal Article International journal of pediatric otorhinolaryngology · February 2017 ObjectiveLittle is known regarding the diagnosis and management of pediatric surgical conditions of the head and neck in low-income countries. Haiti, the western hemisphere's poorest country, recently developed its first Otorhinolaryngology (ORL) ... Full text Cite

Vaginal Self-Sampling for Human Papillomavirus Infection as a Primary Cervical Cancer Screening Tool in a Haitian Population.

Journal Article Sex Transm Dis · November 2015 BACKGROUND: Human papillomavirus (HPV) testing as primary cervical cancer screening has not been studied in Caribbean women. We tested vaginal self-collection versus physician cervical sampling in a population of Haitian women. METHODS: Participants were s ... Full text Open Access Link to item Cite

International aid and natural disasters: a pre- and post-earthquake longitudinal study of the healthcare infrastructure in Leogane, Haiti.

Journal Article The American journal of tropical medicine and hygiene · February 2015 The reconstruction of healthcare systems in developing countries after natural disasters is poorly understood. Using data collected before and after the 2010 Haiti earthquake, we detail the response of aid agencies and their interaction with local healthca ... Full text Cite

Human papillomavirus prevalence in a population of women living in Port-au-Prince and Leogane, Haiti.

Journal Article PloS one · January 2013 BackgroundThere have been no published studies of carcinogenic human papillomavirus (HPV)--the necessary cause of cervical cancer--in Haiti, a nation that has one of the greatest burdens of cervical cancer globally.ObjectiveCharacterize p ... Full text Cite

Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements.

Journal Article Reproductive toxicology (Elmsford, N.Y.) · July 2012 A total of 256 men were studied to evaluate whether serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) impacted semen quality or reproductive hormones. Blood and semen were collected and analyzed for perfluorochemicals a ... Full text Cite

Unmet health needs identified by Haitian women as priorities for attention: a qualitative study.

Journal Article Reprod Health Matters · June 2012 This 2009 qualitative study investigated Haitian women's most pressing health needs, barriers to meeting those needs and proposed solutions, and how they thought the community and outside organizations should be involved in addressing their needs. The impe ... Full text Link to item Cite

Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure.

Journal Article Optics express · September 2011 Quantitative optical spectroscopy has the potential to provide an effective low cost, and portable solution for cervical pre-cancer screening in resource-limited communities. However, clinical studies to validate the use of this technology in resource-limi ... Full text Open Access Cite

A pilot analytic study of a research-level, lower-cost human papillomavirus 16, 18, and 45 test.

Journal Article Journal of virological methods · September 2011 The analytic performance of a low-cost, research-stage DNA test for the most carcinogenic human papillomavirus (HPV) genotypes (HPV16, HPV18, and HPV45) in aggregate was evaluated among carcinogenic HPV-positive women, which might be used to decide who nee ... Full text Cite

Endometrial injury via saline-infusion sonohysterogram (SIS) performed within one month of cycle start does not improve live birth rate

Conference Fertility and Sterility · September 2011 Full text Cite

Calibration schemes of a field-compatible optical spectroscopic system to quantify neovascular changes in the dysplastic cervix

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 2, 2011 A significant challenge in detecting cervical pre-cancer in low-resource settings is the lack of effective screening facilities and trained personnel to detect the disease before it is advanced. Light based technologies, particularly quantitative optical s ... Full text Cite

A feasibility study to evaluate pelvic peritoneal anatomy with a saline intraperitoneal sonogram (SIPS).

Journal Article Fertility and sterility · December 2010 ObjectiveTo prove the safety and feasibility of evaluating pelvic anatomy with a new imaging technique called saline intraperitoneal sonogram (SIPS).DesignProspective clinical case series.SettingOutpatient fertility clinic.Pa ... Full text Cite

Pregnancy in the setting of low and undetectable serum anti-mullerian hormone (AMH)

Conference Fertility and Sterility · September 2010 Full text Cite

Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture.

Journal Article Cell Commun Signal · June 10, 2010 BACKGROUND: Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma- ... Full text Open Access Link to item Cite

Fertility patients' views about frozen embryo disposition: results of a multi-institutional U.S. survey.

Journal Article Fertil Steril · February 2010 OBJECTIVE: To describe fertility patients' preferences for disposition of cryopreserved embryos and determine factors important to these preferences. DESIGN: Cross-sectional survey conducted between June 2006 and July 2007. SETTING: Nine geographically div ... Full text Link to item Cite

Transport theory for HIV diffusion through in vivo distributions of topical microbicide gels.

Journal Article Biophysical journal · November 2009 Topical microbicide products are being developed for the prevention of sexually transmitted infections. These include vaginally-applied gels that deliver anti-HIV molecules. Gels may also provide partial barriers that slow virion diffusion from semen to vu ... Full text Cite

Improving IVF Utilization with Patient-Centric Artificial Intelligence-Machine Learning (AI/ML): A Retrospective Multicenter Experience.

Perceived Feasibility, Acceptability, and Cultural Adaptation for a Mental Health Intervention in Rural Haiti.

Prevalence of hypertension and peripheral arterial disease in adults in Léogâne, Haiti

Journal Article Journal of Global Health Reports · May 1, 2019 Full text Open Access Cite

Head and Neck Cancer in Haiti: A Case Series from Hopital de L'Universite d'Etat d'Haiti.

The socioeconomic impact of international aid: a qualitative study of healthcare recovery in post-earthquake Haiti and implications for future disaster relief.

Otorhinolaryngology/Head and Neck Surgery in a low income country: The Haitian experience.

Vaginal Self-Sampling for Human Papillomavirus Infection as a Primary Cervical Cancer Screening Tool in a Haitian Population.

International aid and natural disasters: a pre- and post-earthquake longitudinal study of the healthcare infrastructure in Leogane, Haiti.

Human papillomavirus prevalence in a population of women living in Port-au-Prince and Leogane, Haiti.

Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements.

Unmet health needs identified by Haitian women as priorities for attention: a qualitative study.

Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure.

A pilot analytic study of a research-level, lower-cost human papillomavirus 16, 18, and 45 test.

Endometrial injury via saline-infusion sonohysterogram (SIS) performed within one month of cycle start does not improve live birth rate

Conference Fertility and Sterility · September 2011 Full text Cite

Calibration schemes of a field-compatible optical spectroscopic system to quantify neovascular changes in the dysplastic cervix

A feasibility study to evaluate pelvic peritoneal anatomy with a saline intraperitoneal sonogram (SIPS).

Pregnancy in the setting of low and undetectable serum anti-mullerian hormone (AMH)

Conference Fertility and Sterility · September 2010 Full text Cite

Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture.

Fertility patients' views about frozen embryo disposition: results of a multi-institutional U.S. survey.

Transport theory for HIV diffusion through in vivo distributions of topical microbicide gels.

Prevalence and severity of cervical squamous intraepithelial lesion in a tertiary hospital in northern Tanzania.

Journal Article Tanzania journal of health research · October 2009 Cervical cancer is the second most common cancer in women worldwide and the leading cause of cancer deaths in Tanzanian women. Prevention of cervical cancer relies on the detection and treatment of Squamous Intraepithelial Lesion (SIL), a premalignant dise ... Full text Cite

Heterotopic cervical pregnancy treated with transvaginal ultrasound-guided aspiration resulting in cervical site varices within the myometrium.

Journal Article Fertil Steril · March 2009 OBJECTIVE: To report a case of successful treatment of a heterotopic cervical pregnancy from IVF-embryo transfer and intracytoplasmic sperm injection (ICSI) that resulted in uterine varices at the cervical site. DESIGN: Case report. SETTING: Tertiary unive ... Full text Link to item Cite

Transport Theory For HIV Migration Through In Vivo Distributions Of Microbicide Epithelial Coating Layers

Conference Biophysical Journal · February 2009 Full text Cite

Simple vaginal mold for use in the postoperative care of patients with a transverse vaginal septum.

Journal Article Fertil Steril · May 2007 Severe vaginal stenosis is a potentially disabling complication of transverse vaginal septum resection due to the constriction of the resulting circular scar. We describe a vaginal mold that can be easily created by an occupational therapist, and used as a ... Full text Link to item Cite

Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome.

Journal Article Fertil Steril · November 2006 Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders seen among reproductive-age women, with a prevalence of 4%-9% depending on the criteria used to define the syndrome. The diagnostic criteria for PCOS have been surprisingly cont ... Full text Link to item Cite

Ectopic pregnancy in a preexisting hydrosalpinx during a spontaneous pregnancy.

Journal Article Fertil Steril · October 2006 OBJECTIVE: To discuss the possible role of abnormal embryo migration as a cause of ectopic pregnancy during IVF with hydrosalpinges. DESIGN: Case report. SETTING: University-based reproductive endocrinology and fertility clinic. PATIENT(S): A patient prese ... Full text Link to item Cite

P-672

Conference Fertility and Sterility · September 2006 Full text Cite

Factors that affect infertility patients' decisions about disposition of frozen embryos.

Journal Article Fertil Steril · June 2006 OBJECTIVE: To describe factors that affect infertility patients' decision making regarding their cryopreserved embryos. DESIGN: Forty-six semistructured in-depth interviews of individuals and couples participating in IVF programs. SETTING: Two major southe ... Full text Link to item Cite

Reply: Predictive value of the sperm chromatin assay in different populations [2]

Journal Article Fertility and Sterility · March 1, 2006 Full text Cite

Reply: Predictive value of the sperm chromatin assay in different populations [4]

Journal Article Fertility and Sterility · March 1, 2006 Full text Cite

Optical imaging and analysis of human vaginal coating by drug delivery gels

Journal Article Contraception · 2006 Cite

Relationship between pre-embryo pronuclear morphology (zygote score) and standard day 2 or 3 embryo morphology with regard to assisted reproductive technique outcomes.

Journal Article Fertil Steril · October 2005 OBJECTIVE: To test the hypothesis that pregnancy rates are low if grade Z1 pre-embryos are not available for transfer and to determine if pronuclear morphology is a better predictor of pregnancy than traditional embryo morphology. DESIGN: Prospective clini ... Full text Link to item Cite

Redefining the relationship between sperm deoxyribonucleic acid fragmentation as measured by the sperm chromatin structure assay and outcomes of assisted reproductive techniques.

Journal Article Fertil Steril · August 2005 OBJECTIVE: To test the hypothesis that couples with sperm chromatin structure assay (SCSA) DNA fragmentation index (DFI) values >27% would not achieve pregnancy with assisted reproductive techniques (ART) and to investigate how DFI and high DNA stainabilit ... Full text Link to item Cite

Mullerian agenesis and thrombocytopenia absent radius syndrome: a case report and review of syndromes associated with Mullerian agenesis.

Journal Article Obstet Gynecol Surv · July 2005 UNLABELLED: Mullerian agenesis, commonly referred to as Mayer-Rokitansky-Kuster-Hauser syndrome (MRKHS), is a congenital defect that is most commonly associated with renal and spinal malformations. It is very rare for Mullerian agenesis to be accompanied b ... Full text Link to item Cite

Optical instrument for measurement of vaginal coating thickness by drug delivery formulations

Journal Article Review of Scientific Instruments · March 1, 2005 An optical device has been developed for imaging the human vaginal epithelial surfaces, and quantitatively measuring distributions of coating thickness of drug delivery formulations-such as gels-applied for prophylaxis, contraception or therapy. The device ... Full text Cite

Successful pregnancies in patients with estrogenic anovulation after low-dose human chorionic gonadotropin therapy alone following hMG for controlled ovarian hyperstimulation.

Journal Article Journal of assisted reproduction and genetics · January 2005 ObjectiveTo demonstrate that folliculogenesis can be sustained with 200 IU human chorionic gonadotropins (hCG) after FSH-priming and result in pregnancy in women with estrogenic ovulatory dysfunction and risk factors for severe ovarian hyperstimul ... Full text Cite

Portable colposcopy in low-resource settings.

Journal Article Journal of acquired immune deficiency syndromes (1999) · October 2004 Screening for cervical dysplasia is an important public health effort worldwide. In unscreened populations, the incidence of cervical cancer ranges between 2 and 4% of the adult female population, whereas less than 0.1% of the screened population of Caucas ... Cite

The relationship between embryo pronuclear morphology (Zygote score) and standard day 2 or 3 embryo morphology on assisted reproductive technique outcomes

Conference Fertility and Sterility · September 2004 Full text Cite

Redefining the relationship between sperm DNA fragmentation as measured by the sperm chromatin structure assay (SCSA®) and outcomes of assisted reproductive techniques (ART)

Conference Fertility and Sterility · September 2004 Full text Cite

Portable colposcopy in low-resource settings

Journal Article Journal of Acquired Immune Deficiency Syndromes · 2004 Screening for cervical dysplasia is an important public health effort worldwide. In unscreened populations, the incidence of cervical cancer ranges between 2 and 4% of the adult female population, whereas less than 0.1% of the screened population of Caucas ... Cite

Insulin-like growth factor-1 regulates VEGF expression in primary human uterine epithelial cells.

Conference FERTILITY AND STERILITY · September 1, 2003 Link to item Cite

Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta.

Journal Article J Natl Cancer Inst · January 2, 2002 BACKGROUND: Oral contraceptive (OC) use is associated with a reduced risk of ovarian cancer. An OC component, progestin, induces apoptosis in the primate ovarian epithelium. One regulator of apoptosis is transforming growth factor-beta (TGF-beta). We deter ... Full text Link to item Cite

Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium.

Journal Article Molecular human reproduction · January 2002 We have previously shown that the estrogen responsiveness of the human lactoferrin gene in a transient transfection system is mediated through an imperfect estrogen response element (ERE) and a steroidogenic factor 1 binding element (SFRE) 26 bp upstream f ... Full text Cite

E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway.

Journal Article Endocrinology · September 2001 The insulin receptor substrates are docking proteins that bind various receptor tyrosine kinases and signaling proteins. Previous studies have shown that E2 or progesterone can regulate the relative abundance of insulin receptor substrate-1 and -2 in cells ... Cite

Posture influences vaginal gel distributions in women: in vivo studies.

Journal Article Fertility and Sterility · September 2001 Full text Cite

Sexual satisfaction and functioning in patients seeking infertility treatment.

Journal Article Fertility and Sterility · September 2001 Full text Cite

Advances in uterine leiomyoma research: conference overview, summary, and future research recommendations.

Journal Article Environ Health Perspect · October 2000 Uterine leiomyomas (fibroids, myomas) are the most common tumors occurring in the genital tract of women over 30 years of age. These benign uterine smooth-muscle tumors are estimated to be clinically significant in at least 25% of the American female popul ... Full text Link to item Cite

Advances in uterine leiomyoma research: Conference overview, summary, and future research recommendations

Journal Article Environmental Health Perspectives · 2000 Uterine leiomyomas (fibroids, myomas) are the most common tumors occurring in the genital tract of women over 30 years of age. These benign uterine smooth-muscle tumors are estimated to be clinically significant in at least 25% of the American female popul ... Cite

Evidence of juxtacrine signaling for transforming growth factor alpha in human endometrium.

Journal Article Biology of reproduction · December 1998 To determine the mechanism of signaling for transforming growth factor alpha (TGFalpha) in human endometrium, uterine luminal fluid proteins were retrieved by lavage followed by collection of the adjacent endometrium at hysterectomy. In the endometrium we ... Cite

Effects of dietary soybean estrogens on the reproductive tract in female rats.

Journal Article Proc Soc Exp Biol Med · March 1998 The estrogenic actions of dietary phytoestrogens have raised concerns regarding the potential DES-like developmental effects on the female genital tract, but the growing evidence of cardioprotective benefits of dietary soybean estrogens provides the impetu ... Full text Link to item Cite

Effect of progestin on the ovarian epithelium of macaques: cancer prevention through apoptosis?

Journal Article J Soc Gynecol Investig · 1998 OBJECTIVE: The apoptosis pathway is a vital mechanism in vivo that functions to eradicate genetically damaged cells prone to malignancy. The purpose of this study was to determine whether oral contraceptives, which confer significant protection against sub ... Full text Link to item Cite

Toxicity of methoxyacetic acid in cultured human luteal cells.

Journal Article Fundamental and applied toxicology : official journal of the Society of Toxicology · August 1997 Ethylene glycol monomethyl ether (EGME) and its proximate metabolite, 2-methoxyacetic acid (MAA), increase ovarian luteal cell progesterone production in the female rat in vivo and in cultured rat luteal cells in vitro, respectively. In order to better ass ... Full text Cite

Evaluation of the postcoital test in cycles involving exogenous gonadotropins.

Journal Article Obstetrics and gynecology · May 1997 ObjectiveTo evaluate the hypothesis that a postcoital test, optimally performed in the periovulatory period of cycles in which gonadotropin-induced superovulation was used, correlates with cycle fecundity.MethodsOf 1135 total consecutive ... Full text Cite

Advanced maternal age and perinatal outcome: oocyte recipiency versus natural conception.

Journal Article Obstet Gynecol · April 1997 OBJECTIVE: To compare perinatal outcome in older oocyte recipients with that in women of advanced maternal age who conceived without assisted reproductive technologies. METHODS: We performed a retrospective cohort study of 46 oocyte recipients and 49 women ... Full text Link to item Cite

Human endometrial transforming growth factor-alpha: a transmembrane, surface epithelial protein that transiently disappears during the midsecretory phase of the menstrual cycle.

Journal Article J Soc Gynecol Investig · 1997 OBJECTIVES: To characterize the forms of transforming growth factor-alpha (TGF-alpha) in normal human endometrium, to evaluate the regional and temporal changes in TGF-alpha expression, and to correlate the pattern of TGF-alpha expression with physiologic ... Full text Link to item Cite

p53lyn and p56lyn: a new signaling pathway in human endometrium and endometrial adenocarcinomas.

Journal Article J Soc Gynecol Investig · 1997 OBJECTIVE: To identify specific tyrosine kinases that are involved in endometrial signaling and to study their in vivo expression in normal and abnormal endometrium. We hypothesized that proteins that are differentially expressed would be more likely to be ... Link to item Cite

A method for observation and analysis of contraceptive gel spreading and retention on the vaginal epithelium.

Journal Article FERTILITY AND STERILITY · January 1, 1997 Link to item Cite

Potentiation of diethylstilbestrol-induced alterations in the female mouse reproductive tract by transforming growth factor-alpha transgene expression.

Journal Article Molecular carcinogenesis · November 1996 Neonatal estrogen exposure causes numerous abnormalities in the female reproductive tract, including carcinogenesis. One mechanism by which neonatal estrogen elicits teratogenic and carcinogenic effects is epigenetic and involves the modulation of a number ... Full text Cite

Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation.

Journal Article Endocrinology · November 1995 Previous investigation of ligand and receptor messenger RNA (mRNA) expression implicated the platelet-derived growth factor (PDGF) pathway as a participant in the maintenance of pregnancy and fetal development during the first half of murine gestation. We ... Full text Cite

Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein.

Journal Article Cancer Res · March 1, 1995 In the mouse uterus, lactoferrin is a major estrogen-inducible uterine secretory protein, and its expression correlates directly with the period of peak epithelial cell proliferation. In this study, we examine the expression of lactoferrin mRNA and protein ... Link to item Cite

Descriptive histology. The gold standard for clinically evaluating the endometrium

Journal Article Infertility and Reproductive Medicine Clinics of North America · January 1, 1995 Cite

The effect of neonatal exposure to diethylstilbestrol, coumestrol, and beta-sitosterol on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat.

Journal Article Proc Soc Exp Biol Med · January 1995 The neonatal hormone environment influences the sexually differentiated patterns of development. Estrogens, derived from intracerebral aromatization, promote male pattern development of the central nervous system. The purpose of this study was to determine ... Full text Link to item Cite

Transforming growth factors beta 1, beta 2, and beta 3 messenger RNA and protein expression in mouse uterus and vagina during estrogen-induced growth: a comparison to other estrogen-regulated genes.

Journal Article Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research · September 1994 Increasing evidence suggests that the differential regulation of multiple peptide growth factors by steroid hormones contributes significantly to the pleiotropic effects elicited in target tissues. We report here an evaluation of the effects of the potent ... Cite

Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse.

Journal Article Molecular endocrinology (Baltimore, Md.) · November 1992 The 5'-flanking region of the human lactoferrin gene was isolated from a human placental genomic library. This genomic clone contains a 16-kilobase pair (kbp) insert and produces seven fragments when digested with the SacI restriction enzyme. We sequenced ... Full text Cite

Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone.

Journal Article Endocrinology · September 1992 Lactoferrin (LTF), an iron-binding glycoprotein present in most exocrine secretions and in the secondary granules of polymorphonuclear leucocytes (PMN), is regulated by estrogen in the mouse reproductive tract. We investigated the expression of LTF mRNA an ... Full text Link to item Cite

Human granulosa-luteal and cumulus cells express transforming growth factors-beta type 1 and type 2 mRNA.

Journal Article J Clin Endocrinol Metab · February 1992 Human granulosa-luteal cells and cumulus cells obtained from women undergoing in vitro fertilization and embryo transfer (IVF-ET) were examined for the presence of TGF-beta 1 and TGF-beta 2 mRNA by reverse transcription-polymerase chain reaction (RT-PCR) a ... Full text Link to item Cite

Adjunctive leuprolide therapy does not improve cycle fecundity in controlled ovarian hyperstimulation and intrauterine insemination of subfertile women.

Journal Article Obstet Gynecol · August 1991 Problems arising from controlled ovarian hyperstimulation for intrauterine insemination, such as premature luteinization and asynchronous ovarian follicular development, are identical to those encountered with controlled ovarian hyperstimulation for in vit ... Link to item Cite

Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · January 1991 The in vivo studies presented here demonstrate that epidermal growth factor (EGF) is an important autocrine and/or paracrine mediator of estrogen-induced growth and differentiation in mouse uterus and vagina. An antibody specific for EGF significantly inhi ... Full text Cite

Utility of fluoroimmunoassay in detecting luteinizing hormone surges in spontaneous and human menopausal gonadotropin-stimulated menstrual cycles.

Journal Article J Reprod Med · March 1990 Luteinizing hormone (LH) levels measured with radioimmunoassay and time-resolved fluoroimmunoassay (FIA) in 274 serum samples correlated highly, with a linear correlation coefficient of 0.934. Through the analysis of serial samples from 43 women undergoing ... Link to item Cite

Ovarian hyperstimulation in polycystic ovary syndrome during therapy with leuprolide acetate.

Journal Article Fertility and sterility · November 1989 Continuous exposure to GnRH eliminates the pituitary as a source of gonadotropins and may have direct suppressive effects on the ovary. A woman with PCO syndrome received leuprolide acetate (1 mg/d SC) for 4 weeks before and simultaneously with hMG stimula ... Full text Cite

Enterococci in post-cesarean endometritis.

Journal Article Obstetrics and gynecology · February 1988 Three hundred eleven patients with post-cesarean endometritis were treated with clindamycin and gentamicin. Isolation of enterococci in the endometrium was associated with use of cephalosporin prophylaxis (P less than .001). Other risk factors for enteroco ... Cite