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Deb Ashish Bhowmick

Associate Professor of Neurosurgery
Neurosurgery

Selected Publications


Machine learning for automated and real-time two-dimensional to three-dimensional registration of the spine using a single radiograph.

Journal Article Neurosurg Focus · June 2023 OBJECTIVE: The goal of this work was to methodically evaluate, optimize, and validate a self-supervised machine learning algorithm capable of real-time automatic registration and fluoroscopic localization of the spine using a single radiograph or fluorosco ... Full text Link to item Cite

Minimally invasive modification of the Goel-Harms atlantoaxial fusion technique: a case series and illustrative guide.

Journal Article Neurosurg Focus · March 2023 OBJECTIVE: The Goel-Harms atlantoaxial screw fixation technique for the treatment of atlantoaxial instability and unstable odontoid fractures is reliable and reproducible for a variety of anatomies. The drawbacks of the technique are the potential for sign ... Full text Link to item Cite

Novel use of percutaneous cervical pedicle inlet screws for supplemental posterior fixation after anterior cervical deformity correction

Journal Article Journal of Craniovertebral Junction and Spine · July 1, 2021 Introduction: Correction of cervical deformity can be achieved using anterior cervical fixation and fusion techniques. However, supplemental posterior fixation is a critical component for ensuring biomechanical longevity and favorable patient outcomes. We ... Full text Cite

Limitations on Postoperative Opioid Prescriptions and Effects on Health Care Resource Use Following Elective Anterior Cervical Discectomy and Fusion.

Journal Article World Neurosurg · February 2021 OBJECTIVE: To curb the misuse of postoperative prescription opioids, the state of North Carolina enacted the Strengthen Opioid Misuse Prevention (STOP) Act of 2017 limiting the duration of initial postoperative opioid prescriptions. The purpose of this stu ... Full text Link to item Cite

SI Joint Fixation

Chapter · January 1, 2021 Surgical fixation of the sacroiliac joint (SIJ) has increased in popularity over the last few decades, especially with the recent emergence of minimally invasive techniques. The indications for this procedure are expanding and include joint dysfunction, de ... Full text Cite

Gender Disparities in Surgical Treatment of Axis Fractures in Older Adults

Journal Article Global Spine Journal · January 1, 2021 Study Design: Retrospective cohort study. Objectives: Gender appears to play in important role in surgical outcomes following acute cervical spine trauma, with current literature suggesting males have a significantly higher mortality following spine surger ... Full text Cite

1-Year Mortality and Surgery Incidence in Older US Adults with Cervical Spine Fracture.

Journal Article World Neurosurg · September 2020 BACKGROUND: Traumatic cervical spinal cord injuries (SCIs) can be lethal and are especially dangerous for older adults. Falls from standing and risk factors for a cervical fracture and spinal cord injury increase with age. This study estimates the 1-year m ... Full text Link to item Cite

Comparative Propensity-Weighted Mortality After Isolated Acute Traumatic Axis Fractures in Older Adults

Journal Article Geriatric Orthopaedic Surgery and Rehabilitation · January 1, 2020 Introduction: In older patients with axis fractures, the survival benefit from surgery is unclear due to high baseline mortality. Comparative effectiveness research can provide evidence from population level cohorts. Propensity weighting is the preferred m ... Full text Cite

Use of C2 vertebroplasty and stereotactic radiosurgery for treatment of lytic metastasis of the odontoid process

Journal Article Journal of Craniovertebral Junction and Spine · July 1, 2017 Improvements in cancer therapy have led to increased patient survival times in spite of metastatic spinal disease in many forms of cancer. Conventional treatment methods often employ radiotherapy with or without surgery depending on the neurological status ... Full text Cite

Variant prostate carcinoma and elevated serum CA-125.

Journal Article Can J Urol · October 2014 INTRODUCTION: About 10% of tumors derived from nongynecologic, noncoelomic tissues react with the OC125 antibody. Some patients with advanced prostate cancer were found to have elevated serum CA-125 level. MATERIALS AND METHODS: We examined the clinical hi ... Link to item Cite

Biomechanical analysis of the upper thoracic spine after decompressive procedures.

Journal Article Spine J · June 1, 2014 BACKGROUND CONTEXT: Decompressive procedures such as laminectomy, facetectomy, and costotransversectomy are routinely performed for various pathologies in the thoracic spine. The thoracic spine is unique, in part, because of the sternocostovertebral articu ... Full text Link to item Cite

Minimally invasive, robot-assisted, anterior lumbar interbody fusion: a technical note.

Journal Article J Neurol Surg A Cent Eur Neurosurg · July 2013 BACKGROUND: Minimally invasive techniques in spine surgery have gained significant popularity due to decreased tissue dissection and destruction, postoperative pain, and hospital stay. The laparoscopic anterior lumbar interbody fusion (ALIF), an innovation ... Full text Link to item Cite

Salvage C2 ganglionectomy after C2 nerve root decompression provides similar pain relief as a single surgical procedure for intractable occipital neuralgia.

Journal Article World Neurosurg · February 2012 OBJECTIVE: To determine the effectiveness of C2 nerve root decompression and C2 dorsal root ganglionectomy for intractable occipital neuralgia (ON) and C2 ganglionectomy after pain recurrence following initial decompression. METHODS: A retrospective review ... Full text Link to item Cite

Da Vinci Robot-assisted transoral odontoidectomy for basilar invagination.

Journal Article ORL J Otorhinolaryngol Relat Spec · 2010 The transoral approach is an effective way to decompress the craniocervical junction due to basilar invagination. This approach has been described and refined, but significant limitations and technical challenges remain. Specifically, should the transoral ... Full text Link to item Cite

Treatment of pediatric atlantoaxial instability with traditional and modified Goel-Harms fusion constructs.

Journal Article Eur Spine J · June 2009 There are several treatment options for rigid fixation at C1-C2 including Brooks and Gallie type wired fusions and C1-2 transarticular screws. The use of a Goel-Harms type fusion, a construct with C1 lateral mass screws and C2 pedicle screws, has not been ... Full text Link to item Cite

Symptomatic high-flow arteriovenous fistula after a C-2 fracture. Case report.

Journal Article J Neurosurg Spine · April 2008 Spinal arteriovenous fistulas (AVFs) are relatively uncommon lesions that are often diagnosed in a delayed fashion. The authors present a cause of a symptomatic high-flow AVF that developed in a patient after traumatic injury to the upper cervical spine. T ... Full text Link to item Cite

Protein patterns and proteins that identify subtypes of glioblastoma multiforme.

Journal Article Oncogene · September 2, 2004 Glioblastoma multiforme (GBM) has been subdivided into two types based on clinical and genetic findings: primary tumors, which arise de novo, and secondary tumors, which progress from lower grade gliomas to GBMs. To analyse this dichotomy at the protein le ... Full text Link to item Cite

Machine learning for automated and real-time two-dimensional to three-dimensional registration of the spine using a single radiograph.

Journal Article Neurosurg Focus · June 2023 OBJECTIVE: The goal of this work was to methodically evaluate, optimize, and validate a self-supervised machine learning algorithm capable of real-time automatic registration and fluoroscopic localization of the spine using a single radiograph or fluorosco ... Full text Link to item Cite

Minimally invasive modification of the Goel-Harms atlantoaxial fusion technique: a case series and illustrative guide.

Journal Article Neurosurg Focus · March 2023 OBJECTIVE: The Goel-Harms atlantoaxial screw fixation technique for the treatment of atlantoaxial instability and unstable odontoid fractures is reliable and reproducible for a variety of anatomies. The drawbacks of the technique are the potential for sign ... Full text Link to item Cite

Novel use of percutaneous cervical pedicle inlet screws for supplemental posterior fixation after anterior cervical deformity correction

Journal Article Journal of Craniovertebral Junction and Spine · July 1, 2021 Introduction: Correction of cervical deformity can be achieved using anterior cervical fixation and fusion techniques. However, supplemental posterior fixation is a critical component for ensuring biomechanical longevity and favorable patient outcomes. We ... Full text Cite

Limitations on Postoperative Opioid Prescriptions and Effects on Health Care Resource Use Following Elective Anterior Cervical Discectomy and Fusion.

Journal Article World Neurosurg · February 2021 OBJECTIVE: To curb the misuse of postoperative prescription opioids, the state of North Carolina enacted the Strengthen Opioid Misuse Prevention (STOP) Act of 2017 limiting the duration of initial postoperative opioid prescriptions. The purpose of this stu ... Full text Link to item Cite

SI Joint Fixation

Chapter · January 1, 2021 Surgical fixation of the sacroiliac joint (SIJ) has increased in popularity over the last few decades, especially with the recent emergence of minimally invasive techniques. The indications for this procedure are expanding and include joint dysfunction, de ... Full text Cite

Gender Disparities in Surgical Treatment of Axis Fractures in Older Adults

Journal Article Global Spine Journal · January 1, 2021 Study Design: Retrospective cohort study. Objectives: Gender appears to play in important role in surgical outcomes following acute cervical spine trauma, with current literature suggesting males have a significantly higher mortality following spine surger ... Full text Cite

1-Year Mortality and Surgery Incidence in Older US Adults with Cervical Spine Fracture.

Journal Article World Neurosurg · September 2020 BACKGROUND: Traumatic cervical spinal cord injuries (SCIs) can be lethal and are especially dangerous for older adults. Falls from standing and risk factors for a cervical fracture and spinal cord injury increase with age. This study estimates the 1-year m ... Full text Link to item Cite

Comparative Propensity-Weighted Mortality After Isolated Acute Traumatic Axis Fractures in Older Adults

Journal Article Geriatric Orthopaedic Surgery and Rehabilitation · January 1, 2020 Introduction: In older patients with axis fractures, the survival benefit from surgery is unclear due to high baseline mortality. Comparative effectiveness research can provide evidence from population level cohorts. Propensity weighting is the preferred m ... Full text Cite

Use of C2 vertebroplasty and stereotactic radiosurgery for treatment of lytic metastasis of the odontoid process

Journal Article Journal of Craniovertebral Junction and Spine · July 1, 2017 Improvements in cancer therapy have led to increased patient survival times in spite of metastatic spinal disease in many forms of cancer. Conventional treatment methods often employ radiotherapy with or without surgery depending on the neurological status ... Full text Cite

Variant prostate carcinoma and elevated serum CA-125.

Journal Article Can J Urol · October 2014 INTRODUCTION: About 10% of tumors derived from nongynecologic, noncoelomic tissues react with the OC125 antibody. Some patients with advanced prostate cancer were found to have elevated serum CA-125 level. MATERIALS AND METHODS: We examined the clinical hi ... Link to item Cite

Biomechanical analysis of the upper thoracic spine after decompressive procedures.

Journal Article Spine J · June 1, 2014 BACKGROUND CONTEXT: Decompressive procedures such as laminectomy, facetectomy, and costotransversectomy are routinely performed for various pathologies in the thoracic spine. The thoracic spine is unique, in part, because of the sternocostovertebral articu ... Full text Link to item Cite

Minimally invasive, robot-assisted, anterior lumbar interbody fusion: a technical note.

Journal Article J Neurol Surg A Cent Eur Neurosurg · July 2013 BACKGROUND: Minimally invasive techniques in spine surgery have gained significant popularity due to decreased tissue dissection and destruction, postoperative pain, and hospital stay. The laparoscopic anterior lumbar interbody fusion (ALIF), an innovation ... Full text Link to item Cite

Salvage C2 ganglionectomy after C2 nerve root decompression provides similar pain relief as a single surgical procedure for intractable occipital neuralgia.

Journal Article World Neurosurg · February 2012 OBJECTIVE: To determine the effectiveness of C2 nerve root decompression and C2 dorsal root ganglionectomy for intractable occipital neuralgia (ON) and C2 ganglionectomy after pain recurrence following initial decompression. METHODS: A retrospective review ... Full text Link to item Cite

Da Vinci Robot-assisted transoral odontoidectomy for basilar invagination.

Journal Article ORL J Otorhinolaryngol Relat Spec · 2010 The transoral approach is an effective way to decompress the craniocervical junction due to basilar invagination. This approach has been described and refined, but significant limitations and technical challenges remain. Specifically, should the transoral ... Full text Link to item Cite

Treatment of pediatric atlantoaxial instability with traditional and modified Goel-Harms fusion constructs.

Journal Article Eur Spine J · June 2009 There are several treatment options for rigid fixation at C1-C2 including Brooks and Gallie type wired fusions and C1-2 transarticular screws. The use of a Goel-Harms type fusion, a construct with C1 lateral mass screws and C2 pedicle screws, has not been ... Full text Link to item Cite

Symptomatic high-flow arteriovenous fistula after a C-2 fracture. Case report.

Journal Article J Neurosurg Spine · April 2008 Spinal arteriovenous fistulas (AVFs) are relatively uncommon lesions that are often diagnosed in a delayed fashion. The authors present a cause of a symptomatic high-flow AVF that developed in a patient after traumatic injury to the upper cervical spine. T ... Full text Link to item Cite

Protein patterns and proteins that identify subtypes of glioblastoma multiforme.

Journal Article Oncogene · September 2, 2004 Glioblastoma multiforme (GBM) has been subdivided into two types based on clinical and genetic findings: primary tumors, which arise de novo, and secondary tumors, which progress from lower grade gliomas to GBMs. To analyse this dichotomy at the protein le ... Full text Link to item Cite

A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease.

Journal Article Cancer Res · February 15, 2004 Glioblastoma multiforme, the most aggressive form of primary brain tumor in adults, is nearly universally fatal, with 5-year survivals of <5% (P. Kleihues and W. K. Cavenee, eds., pp. 1-314, Lyon: IARC, 2000). Alterations in the epidermal growth factor rec ... Full text Link to item Cite

Somatic mutations in VHL germline deletion kindred correlate with mild phenotype.

Journal Article Ann Neurol · February 2004 Generally, von Hippel-Lindau (VHL) disease is caused by a germline mutation of the VHL gene (chromosome 3p), and tumorigenesis is initiated from a "second-hit" deletion. A subset of VHL patients have a germline deletion of the VHL gene, and the molecular e ... Full text Link to item Cite

Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene.

Journal Article Pediatr Neurosurg · 2004 A 4-week-old child presented with lethargy, emesis, decreased spontaneous movements, and a bulging fontanelle. Neuroimaging demonstrated a large, hemispheric, multicystic lesion with multiple enhancing nodules, which, on pathological examination, proved to ... Full text Link to item Cite

Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease.

Journal Article Cancer Res · November 1, 2003 The nature of the cell responsible for von Hippel-Lindau (VHL) disease-associated tumor formation has been controversial for decades. We demonstrate that VHL disease-associated central nervous system tumors are composed of developmentally arrested angiobla ... Link to item Cite

Prostate carcinoma with testicular or penile metastases. Clinical, pathologic, and immunohistochemical features.

Journal Article Cancer · May 15, 2002 BACKGROUND: Despite the proximity, prostate carcinoma seldom metastasizes to the penis or testis. METHODS: In the current study, the authors retrospectively examined the clinical history of 12 patients with prostate carcinoma and testicular or penile metas ... Full text Link to item Cite