Scholars@Duke
Debra L Sudan

Debra L Sudan

Professor of Surgery
Surgery, Abdominal Transplant Surgery
debra.sudan@duke.edu
Box 3512 Med Ctr, Durham, NC 27710
223 Hanes House, Durham, NC 27710

Selected Publications

Trends in the Perioperative Practices for Immunological Assessment and Immunosuppression Strategies for Patients Undergoing Intestinal Transplantation at American Transplant Centers.

Journal Article Transplant Proc · January 30, 2025 BACKGROUND: Intestinal transplantation (IT) is a complex procedure that requires nuanced immunosuppressive strategies to optimize patient outcomes. Despite advancements, significant variability remains in immunosuppressive protocols across transplant cente ... Full text Link to item Cite

Racial Disparities in Liver Transplant for Hepatitis C-Associated Hepatocellular Carcinoma.

Journal Article Ann Surg Oncol · January 2025 BACKGROUND: In the United States, hepatitis C virus-associated hepatocellular carcinoma incidence and mortality are highest among minorities. Socioeconomic constraints play a major role in inequitable treatment. We evaluated the association between race/et ... Full text Link to item Cite

Transforming the logistics of liver transplantation with normothermic machine perfusion: Clinical impact versus cost.

Journal Article Liver Transpl · December 25, 2024 Normothermic machine perfusion (NMP) facilitates utilization of marginal liver allografts. It remains unknown whether clinical benefits offset additional costs in the real-world setting. We performed a comparison of outcomes and hospitalization costs for d ... Full text Link to item Cite

Hepatic Resection as the Primary Treatment Method for Hepatocellular Carcinoma After Orthotopic Liver Transplantation.

Journal Article Ann Surg Oncol · December 2024 BACKGROUND: Liver transplantation (LT) is the treatment of choice for end-stage liver disease and certain malignancies such as hepatocellular carcinoma (HCC). Data on the surgical management of de novo or recurrent tumors that develop in the transplanted a ... Full text Link to item Cite

Risk Factors for Invasive Surgical Site Infections Among Adult Single Liver Transplant Recipients at Duke University Hospital in the Period 2015-2020.

Journal Article Transplant Direct · December 2024 BACKGROUND: Invasive primary surgical site infections (IP-SSI) are a severe complication of liver transplant surgery. Identification of risk factors for IP-SSI is critical to IP-SSI prevention. METHODS: All adult single liver transplants performed at Duke ... Full text Link to item Cite

Normothermic Preservation of the Intestinal Allograft.

Journal Article Gastroenterol Clin North Am · June 2024 Intestinal allotransplantation was first described in the 1960s and successfully performed in the 1980s. Since that time, less progress has been made in the preservation of the allograft before transplantation and static cold storage remains the current st ... Full text Link to item Cite

Late surgical site infections among solid organ transplant recipients: an unrecognized clinical entity.

Journal Article Infect Control Hosp Epidemiol · May 24, 2024 This study identified 26 late invasive primary surgical site infection (IP-SSI) within 4-12 months of transplantation among 2073 SOT recipients at Duke University Hospital over the period 2015-2019. Thoracic organ transplants accounted for 25 late IP-SSI. ... Full text Link to item Cite

Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability.

Conference Am J Transplant · April 2024 Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for intestinal allografts. However, CS and subsequent transplantation induce ischemia-reperfusion injury ... Full text Link to item Cite

Endoscopic Surveillance of the Intestinal Allograft: Recommendations From the Intestinal Rehabilitation and Transplant Association Working Group.

Journal Article Transplantation · April 1, 2024 Intestinal transplant (ITx) rejection lacks a reliable noninvasive biomarker and rejection surveillance relies on serial endoscopies and mucosal biopsies followed by histologic assessment. Endoscopic biopsies are also essential for identifying other ITx-re ... Full text Link to item Cite

Discussion.

Journal Article J Am Coll Surg · April 1, 2024 Full text Link to item Cite

Discussion.

Journal Article J Am Coll Surg · April 1, 2024 Full text Link to item Cite

Limitations of antifungal prophylaxis in preventing invasive Candida surgical site infections after liver transplant surgery.

Journal Article Antimicrob Agents Chemother · March 6, 2024 Invasive primary Candida surgical site infections (IP-SSIs) are a common complication of liver transplantation, and targeted antifungal prophylaxis is an efficient strategy to limit their occurrence. We performed a retrospective single-center cohort study ... Full text Link to item Cite

Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients.

Journal Article Am J Transplant · December 2023 Older compatible living donor kidney transplant (CLDKT) recipients have higher mortality and death-censored graft failure (DCGF) compared to younger recipients. These risks may be amplified in older incompatible living donor kidney transplant (ILDKT) recip ... Full text Link to item Cite

Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.

Journal Article Ann Surg · November 1, 2023 OBJECTIVE: To compare conventional low-temperature storage of transplant donor livers [static cold storage (SCS)] with storage of the organs at physiological body temperature [normothermic machine perfusion (NMP)]. BACKGROUND: The high success rate of live ... Full text Link to item Cite

Predictors of 1-year enteral autonomy in children with intestinal failure: A descriptive retrospective cohort study.

Journal Article JPEN J Parenter Enteral Nutr · November 2023 INTRODUCTION: The International Intestinal Failure Registry (IIFR) is an international consortium to study intestinal failure (IF) outcomes in a large contemporary pediatric cohort. We aimed to identify predictors of early (1-year) enteral autonomy. METHOD ... Full text Link to item Cite

Real-world Experiences in the Transplantation of Hepatitis C-NAAT-positive Organs.

Journal Article Transplant Direct · November 2023 BACKGROUND: Hepatitis C virus (HCV) nucleic acid amplification test (NAAT)-positive donors have increased the organ pool. Direct-acting antivirals (DAAs) have led to high rates of treatment success and sustained virologic response (SVR) in recipients with ... Full text Link to item Cite

Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: Analysis of the US Multicenter HCC Transplant Consortium.

Journal Article Liver Transpl · July 1, 2023 HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT HCC recurrence risk remains an important need. Clinico-radiologic and pathologic data of 4981 pa ... Full text Link to item Cite

Discussion.

Journal Article J Am Coll Surg · April 1, 2023 Full text Link to item Cite

Discussion.

Journal Article J Am Coll Surg · April 1, 2023 Full text Link to item Cite

Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study.

Journal Article Transplant Proc · March 2023 Intestinal transplant and multivisceral transplant were originally in pediatric populations and are relatively new procedures in adults. Despite increasing success rates in the immediate post-transplant period, infectious complications and acute and chroni ... Full text Link to item Cite

An appraisal of technical variant grafts compared to whole liver grafts in pediatric liver transplant recipients: Multicenter analysis from the SPLIT registry.

Journal Article Pediatr Transplant · February 2023 BACKGROUND: Shortages of liver allografts for children awaiting transplantation have led to high LT waitlist mortality. Prior studies have shown that usage of TVG can reduce waiting time and waitlist mortality, but their use is not universal. We sought to ... Full text Link to item Cite

Outcomes in liver transplant recipients with nonalcoholic fatty liver disease-related HCC: results from the US multicenter HCC transplant consortium.

Journal Article Liver Transpl · January 1, 2023 NAFLD will soon be the most common indication for liver transplantation (LT). In NAFLD, HCC may occur at earlier stages of fibrosis and present with more advanced tumor stage, raising concern for aggressive disease. Thus, adult LT recipients with HCC from ... Full text Link to item Cite

Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.

Journal Article Am J Transplant · December 2022 Surgical site infections (SSI) are severe complications of solid organ transplant (SOT). This retrospective study assessed the epidemiology of and outcomes associated with invasive primary SSI (IP-SSI) occurring within 3 months of transplantation in adult ... Full text Open Access Link to item Cite

Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion.

Journal Article Transplant Direct · November 2022 UNLABELLED: Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis and allograft rejection. Improved graft preservation may expand transplantable gra ... Full text Open Access Link to item Cite

Surgical complications after living and deceased donor liver transplant: The NSQIP transplant experience.

Journal Article Clin Transplant · June 2022 This study used the prospective National Surgical Quality Improvement Program (NSQIP) Transplant pilot database to analyze surgical complications after liver transplantation (LT) in LT recipients from 2017to 2019. The primary outcome was surgical complicat ... Full text Link to item Cite

Biliary atresia in a neonate with a history of COVID-19: A case report.

Journal Article Int J Surg Case Rep · January 2022 INTRODUCTION AND IMPORTANCE: Biliary Atresia is the progressive destruction of the neonatal intra- and extra- hepatic bile ducts. The novel coronavirus has shown dramatic hepatic tropism, and patients experiencing liver injury appear to have worse outcomes ... Full text Link to item Cite

Left lateral segment liver volume is not correlated with anthropometric measures.

Journal Article HPB (Oxford) · December 2021 BACKGROUND: Liver transplantation is definitive therapy for end stage liver disease in pediatric patients. Living donor liver transplantation (LDLT) with the left lateral segment (LLS) is often a feasible option. However, the size of LLS is an important fa ... Full text Link to item Cite

Optimal Timing of Administration of Direct-acting Antivirals for Patients With Hepatitis C-associated Hepatocellular Carcinoma Undergoing Liver Transplantation.

Journal Article Ann Surg · October 1, 2021 OBJECTIVE: To investigate the optimal timing of direct acting antiviral (DAA) administration in patients with hepatitis C-associated hepatocellular carcinoma (HCC) undergoing liver transplantation (LT). SUMMARY OF BACKGROUND DATA: In patients with hepatiti ... Full text Link to item Cite

Using Radiographic Domain for Evaluating Indications in Abdominal Wall Transplantation.

Journal Article Ann Plast Surg · September 1, 2021 BACKGROUND: There is currently no description of abdominal domain changes in small bowel transplantation population or consensus of criteria regarding which patients are at high risk for immediate postoperative abdominal wall complications or would benefit ... Full text Link to item Cite

Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe.

Journal Article J Biomed Opt · September 2021 SIGNIFICANCE: The current gold standard for monitoring small intestinal transplant (IT) rejection is endoscopic visual assessment and biopsy of suspicious lesions; however, these lesions are only superficially visualized by endoscopy. Invasive biopsies pro ... Full text Link to item Cite

The Impact of the 2017 Kidney Allocation Policy Change on Simultaneous Liver-Kidney Utilization and Outcomes.

Journal Article Liver Transpl · August 2021 Historically in the United States, kidneys for simultaneous liver-kidney transplantation (SLKT) candidates were allocated with livers, prioritizing SLKT recipients over much of the kidney waiting list. A 2017 change in policy delineated renal function crit ... Full text Link to item Cite

Need for improvements in simultaneous heart-kidney allocation: The limitation of pretransplant glomerular filtration rate.

Journal Article Am J Transplant · July 2021 The incidence of simultaneous heart-kidney transplant (SHK) has increased markedly in the last 15 years. There are no universally agreed upon indications for SHK vs. heart alone (HA) transplant, and center evaluation processes vary widely. We utilized Scie ... Full text Link to item Cite

Efficacy and safety of mammalian target of rapamycin inhibitors following intestinal and multivisceral transplantation.

Journal Article Clin Transplant · July 2021 This is a descriptive study reviewing the outcomes of mammalian target of rapamycin inhibitors (mTORs) in intestinal (IT) and multivisceral transplantation (MVT). This study included 22 patients, 20 adults, and two children, and an overall mean age of 46 y ... Full text Link to item Cite

Transplant social worker and donor financial assistance to increase living donor kidney transplants among African Americans: The TALKS Study, a randomized comparative effectiveness trial.

Journal Article Am J Transplant · June 2021 Lack of donors hinders living donor kidney transplantation (LDKT) for African Americans. We studied the effectiveness of a transplant social worker intervention (TALK SWI) alone or paired with living donor financial assistance to activate African Americans ... Full text Link to item Cite

Posttransplant Outcomes in Older Patients With Hepatocellular Carcinoma Are Driven by Non-Hepatocellular Carcinoma Factors.

Journal Article Liver Transpl · May 2021 The incidence of hepatocellular carcinoma (HCC) is growing in the United States, especially among the elderly. Older patients are increasingly receiving transplants as a result of HCC, but the impact of advancing age on long-term posttransplant outcomes is ... Full text Link to item Cite

Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.

Journal Article World J Surg · May 2021 BACKGROUND: "Textbook outcome" (TO) is a novel composite quality measure that encompasses multiple postoperative endpoints, representing the ideal "textbook" hospitalization for complex surgical procedures. We defined TO for kidney transplantation using a ... Full text Link to item Cite

Understanding the Impact of Pneumonia and Other Complications in Elderly Liver Transplant Recipients: An Analysis of NSQIP Transplant.

Journal Article Transplant Direct · May 2021 UNLABELLED: Despite an increasing demand for liver transplantation in older patients, our understanding of posttransplant outcomes in older recipients is limited to basic recipient and graft survival. Using National Surgical Quality Improvement Program Tra ... Full text Link to item Cite

Delayed graft function and acute rejection following HLA-incompatible living donor kidney transplantation.

Journal Article Am J Transplant · April 2021 Incompatible living donor kidney transplant recipients (ILDKTr) have pre-existing donor-specific antibody (DSA) that, despite desensitization, may persist or reappear with resulting consequences, including delayed graft function (DGF) and acute rejection ( ... Full text Link to item Cite

African Americans' discussions about living-donor kidney transplants with family or friends: Who, what, and why not?

Journal Article Clin Transplant · April 2021 BACKGROUND: Although discussions with family or friends can improve access to living-donor kidney transplantation (LDKT), they remain an understudied step in the LDKT process. METHODS: Among 300 African American transplant candidates, we examined how socio ... Full text Link to item Cite

Preemptive VAE-An Important Tool for Managing Blood Loss in MVT Candidates With PMT.

Journal Article Transplant Direct · March 2021 UNLABELLED: Explantation of native viscera in multivisceral transplant candidates, particularly in those with extensive portomesenteric thrombosis (PMT), carries considerable morbidity due to extensive vascularized adhesions. Preemptive visceral angioembol ... Full text Link to item Cite

Center-level Variation in HLA-incompatible Living Donor Kidney Transplantation Outcomes.

Journal Article Transplantation · February 1, 2021 BACKGROUND: Desensitization protocols for HLA-incompatible living donor kidney transplantation (ILDKT) vary across centers. The impact of these, as well as other practice variations, on ILDKT outcomes remains unknown. METHODS: We sought to quantify center- ... Full text Link to item Cite

Liver Transplantation Outcomes in a U.S. Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria.

Journal Article Hepatology · December 2020 BACKGROUND AND AIMS: The Organ Procurement and Transplantation Network recently approved liver transplant (LT) prioritization for patients with hepatocellular carcinoma (HCC) beyond Milan Criteria (MC) who are down-staged (DS) with locoregional therapy (LR ... Full text Link to item Cite

Abdominal Wall Transplantation: Indications and Outcomes

Journal Article Current Transplantation Reports · December 1, 2020 Purpose of Review: This article aims to review published outcomes associated with full-thickness vascularized abdominal wall transplantation, with particular emphasis on advances in the field in the last 3 years. Recent Findings: Forty-six full-thickness v ... Full text Cite

Textbook Outcomes in Liver Transplantation.

Journal Article World J Surg · October 2020 BACKGROUND: Textbook outcome (TO) is an emerging concept within multiple surgical domains, which represents a novel effort to define a standardized, composite quality benchmark based on multiple postoperative endpoints that represent the ideal "textbook" h ... Full text Link to item Cite

Surgical Techniques for Revascularization in Abdominal Wall Transplantation.

Journal Article J Reconstr Microsurg · September 2020 BACKGROUND:  Abdominal wall vascularized composite allotransplantation (AW-VCA) can be considered as a technically feasible option for abdominal wall reconstruction in patients whose abdomen cannot be closed using traditional methods. However, successful i ... Full text Open Access Link to item Cite

Outcomes in Kidney Transplantation Between Veterans Affairs and Civilian Hospitals: Considerations in the Context of the MISSION Act.

Journal Article Ann Surg · September 1, 2020 OBJECTIVE: We sought to compare kidney transplantation outcomes between Veterans Affairs (VA) and non-VA transplant centers. SUMMARY BACKGROUND DATA: Transplant care at the VA has previously been scrutinized due to geographic and systematic barriers. The r ... Full text Link to item Cite

Synchronous Abdominal Wall and Small-bowel Transplantation: A 1-year Follow-up.

Journal Article Plast Reconstr Surg Glob Open · July 2020 Abdominal wall-vascularized composite allotransplantation (AW-VCA) has evolved as a technically feasible but challenging option in the rare event of abdominal wall reconstruction in patients whose abdomen cannot be closed by applying conventional methods. ... Full text Open Access Link to item Cite

Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome After Liver Transplantation for Hepatocellular Carcinoma: Analysis From the US Multicenter HCC Transplant Consortium.

Journal Article Ann Surg · April 2020 OBJECTIVE: The aim of the study was to determine the rate, predictors, and impact of complete pathologic response (cPR) to pretransplant locoregional therapy (LRT) in a large, multicenter cohort of hepatocellular carcinoma (HCC) patients undergoing liver t ... Full text Link to item Cite

Associations of perceived information adequacy and knowledge with pursuit of live donor kidney transplants and living donor inquiries among African American transplant candidates.

Journal Article Clin Transplant · March 2020 We studied associations between perceived adequacy of live donor kidney transplant (LDKT) information or knowledge with pursuit of LDKT or receipt of live donor inquiries among 300 African American kidney transplant candidates. Participants reported via qu ... Full text Link to item Cite

Society of pediatric liver transplantation: Current registry status 2011-2018.

Journal Article Pediatr Transplant · February 2020 BACKGROUND: SPLIT was founded in 1995 in order to collect comprehensive prospective data on pediatric liver transplantation, including waiting list data, transplant, and early and late outcomes. Since 2011, data collection of the current registry has been ... Full text Link to item Cite

Surgical Resection of Native Viscera to Manage Persistent Ascites after Multivisceral Transplant.

Journal Article Case Rep Transplant · 2020 Multivisceral transplantation is the therapy of choice in patients with diffuse portomesenteric thrombosis. In the present case, we describe a patient who had persistent ascites after multivisceral transplant. The patient was initially diagnosed with a chy ... Full text Link to item Cite

Planned right ventricular support for combined heart-liver transplantation.

Journal Article Interact Cardiovasc Thorac Surg · December 1, 2019 Right ventricular dysfunction post heart transplantation (HTx) is a common problem and its likelihood to occur after combined heart-liver transplantation is even higher. The placement of an extracorporeal planned right ventricular assist device following t ... Full text Link to item Cite

Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer.

Journal Article J Urol · September 2019 PURPOSE: Current trends in renal transplantation, such as improved allograft/recipient survival and expanded organ transplantation eligibility criteria in older recipients, are concomitant with increasingly detected low risk prostate cancer in candidates f ... Full text Link to item Cite

Safety of Everolimus With Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplants: An Analysis From the Randomized TRANSFORM Study.

Journal Article Transplantation · September 2019 BACKGROUND: The safety profiles of standard therapy versus everolimus with reduced-exposure calcineurin inhibitor (CNI) therapy using contemporary protocols in de novo kidney transplant recipients have not been compared in detail. METHODS: TRANSFORM was a ... Full text Link to item Cite

Improvement in Liver Transplant Outcomes From Older Donors: A US National Analysis.

Journal Article Ann Surg · August 2019 OBJECTIVE: To investigate trends in long-term graft and patient outcomes following liver transplantation using grafts from donors ≥60 years old. SUMMARY BACKGROUND DATA: The scarcity of donor livers has led to increased utilization of organs from donors ≥6 ... Full text Link to item Cite

Small bowel and abdominal wall transplantation: A novel technique for synchronous revascularization.

Journal Article Am J Transplant · July 2019 Abdominal wall transplantation (AWT) was introduced in 1999 in the context of reconstruction of complex abdominal wall defects in conjunction with visceral organ transplantation. As of recently, 38 cases of total AWT have been performed worldwide, about ha ... Full text Link to item Cite

Beyond death and graft survival-Variation in outcomes after liver transplant. Results from the NSQIP transplant beta phase.

Journal Article Am J Transplant · July 2019 The National Surgical Quality Program (NSQIP) Transplant program was designed by transplant surgeons from the ground up to track posttransplant outcomes beyond basic recipient and graft survival. After an initial pilot phase, the program has expanded to 29 ... Full text Link to item Cite

Infections after kidney transplantation. Does age matter?

Journal Article Clin Transplant · April 2019 Infections threaten successful outcomes after kidney transplantation. Our aim was to determine if the number, types of infections and the risk factors for common infections differed between older compared to younger kidney transplant (KT) recipients in the ... Full text Link to item Cite

Development of a Telehealth Intervention to Improve Access to Live Donor Kidney Transplantation.

Journal Article Transplant Proc · April 2019 BACKGROUND: Live donor kidney transplantation (LDKT) is underutilized by patients with end-stage kidney disease due to knowledge, communication, and logistical barriers. MATERIAL AND METHODS: The Talking About Live Kidney Donation Social Worker Interventio ... Full text Link to item Cite

Lymphocyte depletion and risk of acute rejection in renal transplant recipients at increased risk for delayed graft function.

Journal Article Am J Transplant · March 2019 Delayed graft function (DGF) is a risk factor for acute rejection (AR) in renal transplant recipients, and KDIGO guidelines suggest use of lymphocyte-depletion induction when DGF is anticipated. We analyzed the United Network for Organ Sharing/Organ Procur ... Full text Link to item Cite

The importance of drug safety and tolerability in the development of new immunosuppressive therapy for transplant recipients: The Transplant Therapeutics Consortium's position statement.

Journal Article Am J Transplant · March 2019 The Transplant Therapeutics Consortium (TTC) is a public-private partnership between the US Food and Drug Administration and the transplantation community including the transplantation societies and members of the biopharmaceutical industry. The TTC was fo ... Full text Link to item Cite

Small Bowel Transplantation.

Journal Article Surg Clin North Am · February 2019 Intestinal and multivisceral transplants are complex technical procedures that present unique challenges in the field of solid organ transplantation. This review aims to highlight the indications, techniques, outcomes, and complications specific to intesti ... Full text Link to item Cite

Single-center analysis of infectious complications in older adults during the first year after kidney transplantation.

Journal Article Eur J Clin Microbiol Infect Dis · January 2019 Infections are among the top three causes of death of older adults in the first year after kidney transplantation (KT). Our aim was to describe infectious complications among KT recipients aged ≥ 65 during the first 12 months post-transplant. Single-center ... Full text Link to item Cite

Comparison between liver transplantation and resection for hilar cholangiocarcinoma: A systematic review and meta-analysis.

Journal Article PLoS One · 2019 BACKGROUND: Hilar cholangiocarcinoma (hCCA) is a rare and aggressive malignancy with R0 resection being currently the only option for long-term survival. With the improvement in the outcomes of liver transplantation (LT), the indications for LT have expand ... Full text Link to item Cite

The Volume-outcome Relationship in Deceased Donor Kidney Transplantation and Implications for Regionalization.

Journal Article Ann Surg · June 2018 OBJECTIVE: The aim of this study was to investigate the volume-outcome relationship in kidney transplantation by examining graft and patient outcomes using standardized risk adjustment (observed-to-expected outcomes). A secondary objective was to examine t ... Full text Link to item Cite

Bleeding and thrombotic complications of pediatric liver transplant.

Journal Article Pediatr Blood Cancer · May 2018 BACKGROUND: Pediatric patients undergoing liver transplant are at significant risk for bleeding and thrombotic complications due to the complex nature of rebalanced hemostasis in patients with liver disease. METHODS/OBJECTIVES: We reviewed records of 92 pe ... Full text Link to item Cite

Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes.

Journal Article Transplant Direct · May 2018 BACKGROUND: Combined lung-liver transplantation (LLT) applies 2 technically challenging transplants in 1 patient with severe 2-organ failure. METHODS: Institutional medical records and United Network for Organ Sharing database were queried for patients at ... Full text Open Access Link to item Cite

Hospital readmissions following HLA-incompatible live donor kidney transplantation: A multi-center study.

Journal Article Am J Transplant · March 2018 Thirty percent of kidney transplant recipients are readmitted in the first month posttransplantation. Those with donor-specific antibody requiring desensitization and incompatible live donor kidney transplantation (ILDKT) constitute a unique subpopulation ... Full text Link to item Cite

Meeting Report of the XIV International Small Bowel Transplant Symposium: Summary of Presentations, Workshops, and Debates From a Comprehensive Meeting on Intestinal Failure, Rehabilitation, and Transplantation, Buenos Aires, Argentina, June 10-13, 2015.

Journal Article JPEN J Parenter Enteral Nutr · February 2018 The 2015 meeting of the Intestinal Transplant Association was held in Buenos Aires, Argentina. This was the 14th International Small Bowel Transplant Symposium, and it was the first meeting organized as a joint venture of the Transplantation Society, the I ... Full text Link to item Cite

The Incremental Cost of Incompatible Living Donor Kidney Transplantation: A National Cohort Analysis.

Journal Article Am J Transplant · December 2017 Incompatible living donor kidney transplantation (ILDKT) has been established as an effective option for end-stage renal disease patients with willing but HLA-incompatible living donors, reducing mortality and improving quality of life. Depending on antibo ... Full text Link to item Cite

Impact of Pretransplant Bridging Locoregional Therapy for Patients With Hepatocellular Carcinoma Within Milan Criteria Undergoing Liver Transplantation: Analysis of 3601 Patients From the US Multicenter HCC Transplant Consortium.

Journal Article Ann Surg · September 2017 OBJECTIVE: To evaluate the effect of pretransplant bridging locoregional therapy (LRT) on hepatocellular carcinoma (HCC) recurrence and survival after liver transplantation (LT) in patients meeting Milan criteria (MC). SUMMARY BACKGROUND DATA: Pre-LT LRT m ... Full text Link to item Cite

Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation.

Journal Article Transplantation · February 2017 BACKGROUND: A recent randomized phase III study of 719 de novo liver transplant recipients showed that early everolimus plus reduced-dose tacrolimus (EVR + rTAC) led to significantly better kidney function than standard TAC (TAC-C), without compromising ef ... Full text Link to item Cite

Could the Use of an Enhanced Recovery Protocol in Laparoscopic Donor Nephrectomy be an Incentive for Live Kidney Donation?

Journal Article Cureus · November 22, 2016 INTRODUCTION AND BACKGROUND: Gastrointestinal (GI) recovery after major abdominal surgery can be delayed from an ongoing need for narcotic analgesia thereby prolonging hospitalization. Enhanced recovery after surgery (ERAS) is a multimodal perioperative ca ... Full text Open Access Link to item Cite

Trends in Usage and Outcomes for Expanded Criteria Donor Kidney Transplantation in the United States Characterized by Kidney Donor Profile Index.

Journal Article Cureus · November 22, 2016 There has been increasing concern in the kidney transplant community about the declining use of expanded criteria donors (ECD) despite improvement in survival and quality of life. The recent introduction of the Kidney Donor Profile Index (KDPI), which prov ... Full text Link to item Cite

Effects of Ideal Versus Total Body Weight Dosage of Rabbit Antithymocyte Globulin on Outcomes of Kidney Transplant Patients With High Immunologic Risk.

Journal Article Exp Clin Transplant · October 2016 OBJECTIVES: The optimal dose of rabbit antithymocyte globulin induction therapy in kidney transplant recipients with high immunologic risk lacks consensus. The purpose of this study was to evaluate the effect of using ideal body weight rather than total bo ... Full text Link to item Cite

Intestinal transplantation.

Journal Article Best Pract Res Clin Gastroenterol · April 2016 Intestinal transplantation has now emerged as a lifesaving therapeutic option and standard of care for patients with irreversible intestinal failure. Improvement in survival over the years has justified expansion of the indications for intestinal transplan ... Full text Link to item Cite

Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial.

Journal Article Am J Kidney Dis · April 2016 BACKGROUND: 1-year data from this trial showed the noninferiority of a novel once-daily extended-release tacrolimus (LCPT; Envarsus XR) to immediate-release tacrolimus (IR-Tac) twice daily after kidney transplantation. STUDY DESIGN: Final 24-month analysis ... Full text Link to item Cite

Survival Benefit with Kidney Transplants from HLA-Incompatible Live Donors.

Journal Article N Engl J Med · March 10, 2016 BACKGROUND: A report from a high-volume single center indicated a survival benefit of receiving a kidney transplant from an HLA-incompatible live donor as compared with remaining on the waiting list, whether or not a kidney from a deceased donor was receiv ... Full text Link to item Cite

Pediatric small bowel transplantation: An update

Chapter · January 1, 2016 Most pediatric patients with irreversible intestinal failure are dependent on parenteral nutrition (PN) and eventually develop life-threatening complications from long-term PN. Intestinal transplantation is now an accepted treatment for the pediatric popul ... Full text Cite

Proceedings of the American Society for Enhanced Recovery/Evidence Based Peri-Operative Medicine 2016 Annual Congress of Enhanced Recovery and Perioperative Medicine: Washington, D.C., USA, 20–22 April 2016.

Journal Article Perioperative Medicine · January 2016 Table of contentsA1 Effects of enhanced recovery pathways on renal functionCharles R. Horres, Mohamed A. Adam, Zhifei Sun, Julie K. Thacker, Timothy J. Miller, Stuart A. GrantA2 Economic outcomes of enhanced recovery after surgery (ERAS)Jeffrey HuangA3 Wha ... Full text Cite

The TALKS study to improve communication, logistical, and financial barriers to live donor kidney transplantation in African Americans: protocol of a randomized clinical trial.

Journal Article BMC Nephrol · October 9, 2015 BACKGROUND: Live donor kidney transplantation (LDKT), an optimal therapy for many patients with end-stage kidney disease, is underutilized, particularly by African Americans. Potential recipient difficulties initiating and sustaining conversations about LD ... Full text Open Access Link to item Cite

Predictors of Enteral Autonomy in Children with Intestinal Failure: A Multicenter Cohort Study.

Journal Article J Pediatr · July 2015 OBJECTIVES: In a large cohort of children with intestinal failure (IF), we sought to determine the cumulative incidence of achieving enteral autonomy and identify patient and institutional characteristics associated with enteral autonomy. STUDY DESIGN: A m ... Full text Link to item Cite

Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement.

Journal Article Crit Care Med · June 2015 This document was developed through the collaborative efforts of the Society of Critical Care Medicine, the American College of Chest Physicians, and the Association of Organ Procurement Organizations. Under the auspices of these societies, a multidiscipli ... Full text Link to item Cite

Discussion.

Journal Article J Am Coll Surg · April 2015 Full text Link to item Cite

Intestinal Rehabilitation and Transplantation: Amazing!

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2015 Link to item Cite

Novel once-daily extended-release tacrolimus (LCPT) versus twice-daily tacrolimus in de novo kidney transplants: one-year results of Phase III, double-blind, randomized trial.

Journal Article Am J Transplant · December 2014 This Phase III randomized trial examined efficacy and safety of a novel once-daily extended-release tacrolimus formulation (LCP-Tacro [LCPT]) versus twice-daily tacrolimus in de novo kidney transplantation. Primary efficacy end point was proportion of pati ... Full text Link to item Cite

Race affects outcome among infants with intestinal failure.

Journal Article J Pediatr Gastroenterol Nutr · October 2014 OBJECTIVE: Intestinal failure (IF) is a rare, devastating condition associated with significant morbidity and mortality. We sought to determine whether ethnic and racial differences were associated with patient survival and likelihood of receiving an intes ... Full text Link to item Cite

Tacrolimus dose requirements in African-American and Caucasian kidney transplant recipients on mycophenolate and prednisone.

Journal Article Clin Transplant · July 2014 Racial differences among kidney transplant recipients may impact the total daily tacrolimus dose required to achieve therapeutic tacrolimus concentrations. Previous studies suggest that African Americans require higher doses to achieve similar therapeutic ... Full text Link to item Cite

Update on surgical therapies for intestinal failure.

Journal Article Curr Opin Organ Transplant · June 2014 PURPOSE OF REVIEW: Parenteral nutrition enables long-term survival in patients with intestinal failure; however, it is associated with life-threatening complications necessitating alternative techniques of management to enable weaning parenteral nutrition ... Full text Link to item Cite

Short bowel syndrome after laparoscopic procedures.

Journal Article Am Surg · April 2014 Short bowel syndrome (SBS) is a potential postoperative complication after intra-abdominal procedures. Whether the laparoscopic approach is as likely to result in SBS or the causative mechanisms are similar to open procedures is unknown. Our aim was to eva ... Link to item Cite

Renal function at two years in liver transplant patients receiving everolimus: results of a randomized, multicenter study.

Journal Article Am J Transplant · July 2013 In a 24-month prospective, randomized, multicenter, open-label study, de novo liver transplant patients were randomized at 30 days to everolimus (EVR) + Reduced tacrolimus (TAC; n = 245), TAC Control (n = 243) or TAC Elimination (n = 231). Randomization to ... Full text Link to item Cite

Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation.

Journal Article Am J Transplant · March 2013 Posterior reversible encephalopathy syndrome (PRES) is a small vessel microangiopathy of the cerebral vasculature that occurs in 0.5-5% of solid organ transplant recipients, most commonly associated with tacrolimus (Tac). Clinical manifestations include hy ... Full text Link to item Cite

Autologous gastrointestinal reconstruction: review of the optimal nontransplant surgical options for adults and children with short bowel syndrome.

Journal Article Nutr Clin Pract · February 2013 Short bowel syndrome (SBS) results in loss of absorptive capacity of the development of gut, leading to malabsorption due to protein, energy, fluid, and electrolyte loss and imbalance while on enteral diet alone. Various nonsurgical and surgical therapeuti ... Full text Link to item Cite

Liver failure

Chapter · January 1, 2013 Full text Cite

Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: a randomized controlled trial.

Journal Article Am J Transplant · November 2012 In a prospective, multicenter, open-label study, de novo liver transplant patients were randomized at day 30±5 to (i) everolimus initiation with tacrolimus elimination (TAC Elimination) (ii) everolimus initiation with reduced-exposure tacrolimus (EVR+Reduc ... Full text Link to item Cite

55-P

Conference Human Immunology · October 2012 Full text Cite

Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium.

Journal Article J Pediatr · October 2012 OBJECTIVE: To characterize the natural history of intestinal failure (IF) among 14 pediatric centers during the intestinal transplantation era. STUDY DESIGN: The Pediatric Intestinal Failure Consortium performed a retrospective analysis of clinical and out ... Full text Link to item Cite

Use of vascularized posterior rectus sheath allograft in pediatric multivisceral transplantation--report of two cases.

Journal Article Am J Transplant · August 2012 Restoring abdominal wall cover and contour in children undergoing bowel and multivisceral transplantation is often challenging due to discrepancy in size between donor and recipient, poor musculature related to birth defects and loss of abdominal wall inte ... Full text Link to item Cite

Multifactorial analysis of the learning curve for robot-assisted laparoscopic biliopancreatic diversion with duodenal switch.

Journal Article Ann Surg · May 2012 OBJECTIVE: To assess the impact of surgeon, patient, and case-specific factors on the learning curve of robot-assisted laparoscopic biliopancreatic diversion with duodenal switch (RA-LBPD/DS). BACKGROUND: The BPD/DS has better resolution of diabetes and hy ... Full text Link to item Cite

186 Long Term Mechanical Circulatory Support: What Are the Final Options?

Conference The Journal of Heart and Lung Transplantation · April 2012 Full text Cite

Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial.

Journal Article Am J Transplant · March 2012 A large prospective, open-label, randomized trial evaluated conversion from calcineurin inhibitor (CNI)- to sirolimus (SRL)-based immunosuppression for preservation of renal function in liver transplantation patients. Eligible patients received liver allog ... Full text Link to item Cite

Stool calprotectin monitoring after small intestine transplantation.

Journal Article Transplantation · May 27, 2011 BACKGROUND: Small intestine transplantation is the only life-saving therapy available for patients with intestinal failure and life-threatening complications of parenteral nutrition, but it is still plagued by high levels of early acute rejection. The abil ... Full text Link to item Cite

Results of a Survey of Transplant Center HCC Imaging Practices

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2011 Link to item Cite

A 25-year experience with postresection short-bowel syndrome secondary to radiation therapy.

Journal Article Am J Surg · December 2010 BACKGROUND: Short-bowel syndrome (SBS) can be caused by abdominal and pelvic malignancies treated by radiation therapy (XRT). The management and long-term outcome of these patients is poorly defined. METHODS: This was a retrospective observational study. W ... Full text Link to item Cite

Intestinal lengthening in adult patients with short bowel syndrome.

Journal Article J Gastrointest Surg · December 2010 INTRODUCTION: Limited information regarding the usefulness of bowel lengthening in adult patients with short bowel syndrome is available. METHODS: Retrospective review of a single center series of intestinal lengthening over 15-year period in patients ≥ 18 ... Full text Link to item Cite

Long-term patient outcome and quality of life after liver transplantation: analysis of 20-year survivors.

Other Ann Surg · October 2010 OBJECTIVE: To evaluate patient survival and allograft function and health-related quality of life (HRQOL) 20 years after orthotopic liver transplantation (LT). SUMMARY OF BACKGROUND DATA: Although LT is the established treatment of choice for acute and chr ... Full text Link to item Cite

The combination of donor and recipient age is critical in determining host immunoresponsiveness and renal transplant outcome.

Other Ann Surg · October 2010 OBJECTIVE: To evaluate the interaction of donor and recipient age on transplant outcome and immune response. SUMMARY BACKGROUND DATA: The age of donor and recipient is becoming increasingly important in organ transplantation. We tested the relevance and co ... Full text Link to item Cite

Adenovirus infections in pediatric small bowel transplant recipients.

Journal Article Transplantation · July 27, 2010 BACKGROUND: Adenovirus is commonly isolated from pediatric small bowel transplant recipients, but its clinical consequences remain poorly understood. METHODS: The medical records of pediatric small bowel transplant recipients transplanted between January 2 ... Full text Link to item Cite

Long-term outcomes and quality of life after intestine transplantation.

Journal Article Curr Opin Organ Transplant · June 2010 PURPOSE OF REVIEW: Over the past decade intestine transplantation has been accepted as standard therapy for patients with life-threatening complications of parenteral nutrition. For patients without life-threatening complications, continued therapy with pa ... Full text Link to item Cite

Cytomegalovirus infection increases the risk for inflammatory bowel disease.

Other Am J Pathol · June 2010 This letter discusses the paper by Onyeagocha et al published in the November 2009 issue of the AJP. ... Full text Link to item Cite

Sublingual Tacrolimus after High Risk Kidney Transplant

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2010 Link to item Cite

Underutilization of Potential Intestine Donors

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2010 Link to item Cite

Plasma nitrite and nitrate levels as a noninvasive marker of pathology after human small bowel transplantation.

Journal Article Transplantation · February 15, 2010 INTRODUCTION: Small bowel transplantation provides a potentially life-saving treatment of severe intestinal failure. Lack of a noninvasive marker of disease makes diagnosis of rejection dependent on frequent endoscopy and biopsy. We hypothesized that incre ... Full text Link to item Cite

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.

Journal Article Am J Physiol Gastrointest Liver Physiol · December 2009 Myofibroblastic hepatic stellate cells (MF-HSC) are derived from quiescent hepatic stellate cells (Q-HSC). Q-HSC express certain epithelial cell markers and have been reported to form junctional complexes similar to epithelial cells. We have shown that Hed ... Full text Link to item Cite

Long-term management of the liver transplant patient: recommendations for the primary care doctor.

Journal Article Am J Transplant · September 2009 No official document has been published for primary care physicians regarding the management of liver transplant patients. With no official source of reference, primary care physicians often question their care of these patients. The following guidelines h ... Full text Link to item Cite

Advances in the nontransplant medical and surgical management of intestinal failure.

Journal Article Curr Opin Organ Transplant · June 2009 PURPOSE OF REVIEW: Although intestinal transplantation is uniquely suited for the treatment of patients with intestinal failure suffering from life-threatening complications, patient survival at 5 years remains suboptimal at approximately 50-60%. RECENT FI ... Full text Link to item Cite

Recipient Characteristics

Chapter · May 5, 2009 Full text Cite

Safety in the OR: who's in and who's out?

Journal Article J Gastrointest Surg · January 2009 Full text Link to item Cite

Humoral Rejection after Liver Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2009 Link to item Cite

Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and review.

Journal Article Pediatr Infect Dis J · November 2008 INTRODUCTION: Infections caused by Leuconostoc species are rare with most reported cases occurring in immunocompromised patients. This article presents 6 new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia, and co ... Full text Link to item Cite

Comparison of short bowel syndrome acquired early in life and during adolescence.

Journal Article Transplantation · July 15, 2008 BACKGROUND: Prolonged survival in pediatric patients with short bowel syndrome (SBS) is now possible because of parenteral nutrition and small bowel transplantation. We hypothesized that there may be important differences between adult patients who develop ... Full text Link to item Cite

Collaborative strategies to reduce mortality and morbidity in patients with chronic intestinal failure including those who are referred for small bowel transplantation.

Journal Article Transplantation · May 27, 2008 UNLABELLED: Intestinal transplant wait-list mortality is higher than for other organ transplants. The objective of this workshop was to identify the main problems contributing to high mortality in adults and children candidates for intestinal transplantati ... Full text Link to item Cite

Repeat surgical bowel lengthening with the STEP procedure.

Journal Article Transplantation · May 15, 2008 BACKGROUND: Feasibility of repeat lengthening has been demonstrated in animals, but in humans, none of the three clinical case reports have achieved enteral autonomy after secondary lengthening with serial transverse enteroplasty (STEP). PATIENTS AND METHO ... Full text Link to item Cite

Short bowel syndrome after continence-preserving procedures.

Journal Article J Gastrointest Surg · January 2008 The short bowel syndrome (SBS) can result from a variety of conditions, including postoperative complications and malignancy. Continence-preserving operations are generally performed for either ulcerative colitis (UC) or familial polyposis (FAP). These pro ... Full text Link to item Cite

Intestinal lengthening for short bowel syndrome.

Journal Article Adv Surg · 2008 Our recommendation at this time is that surgical bowel lengthening be considered in any chronically PN-dependent patient when there is substantial bowel dilation, regardless of remnant bowel length. Timing is determined when maximal adaptation has been ach ... Full text Link to item Cite

What's new in childhood organ transplantation.

Journal Article Pediatr Rev · December 2007 Full text Link to item Cite

Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease

Conference EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY · October 1, 2007 Link to item Cite

Treatment of intestinal failure: intestinal transplantation.

Journal Article Nat Clin Pract Gastroenterol Hepatol · September 2007 Over the past 15 years, intestinal transplantation for the treatment of intestinal failure has changed from a desperate last-ditch effort into a standard therapy for which a good outcome is expected. Patient survival after intestinal transplantation has im ... Full text Link to item Cite

Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database.

Other Am J Transplant · September 2007 Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative facto ... Full text Link to item Cite

Calprotectin: a novel noninvasive marker for intestinal allograft monitoring.

Journal Article Ann Surg · August 2007 OBJECTIVE: To identify a noninvasive screening test for intestinal allograft monitoring. SUMMARY BACKGROUND DATA: Intestinal allograft rejection is difficult to distinguish from other causes of diarrhea and can rapidly lead to severe exfoliation or death. ... Full text Link to item Cite

Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantation.

Journal Article Liver Int · August 2007 BACKGROUND: This study examines the impact of donor liver macrovesicular steatosis on recurrence of hepatitis C virus (HCV) disease after liver transplantation. METHODS: Between 1998 and 2004, 113 patients underwent liver transplantation for HCV-related ci ... Full text Link to item Cite

Role of an intestinal rehabilitation program in the treatment of advanced intestinal failure.

Journal Article J Pediatr Gastroenterol Nutr · August 2007 OBJECTIVE: To analyze outcomes in children with intestinal failure treated by our Intestinal Rehabilitation Program (IRP) in a 4-year period. PATIENTS AND METHODS: A total of 51 parenteral nutrition (PN)-dependent patients (20 male) were enrolled in the IR ... Full text Link to item Cite

Impact of graft type on outcome in pediatric liver transplantation: a report From Studies of Pediatric Liver Transplantation (SPLIT).

Other Ann Surg · August 2007 OBJECTIVE: To examine the outcome of technical variant liver transplant techniques relative to whole organ liver transplantation in pediatric liver transplant recipients. BACKGROUND: Technical variant liver transplant techniques comprising split, reduced, ... Full text Link to item Cite

Robotically assisted biliary pancreatic diversion with a duodenal switch: a new technique.

Journal Article Surg Endosc · May 2007 BACKGROUND: Minimally invasive surgical techniques decrease the length of hospitalization and the morbidity for general surgery procedures. Application of minimally invasive techniques to obesity surgery had previously been limited to stapled techniques us ... Full text Link to item Cite

Short bowel syndrome following bariatric surgical procedures.

Journal Article Am J Surg · December 2006 BACKGROUND: Short bowel syndrome (SBS) is a potential postoperative complication that is occurring with increasing frequency after bariatric procedures (BP). As long-term follow-up data are available, unusual long-term complications are being identified. O ... Full text Link to item Cite

Transplantation for cholangiocarcinoma.

Journal Article Liver Transpl · November 2006 Full text Link to item Cite

Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome.

Journal Article Liver Transpl · July 2006 Infants with short bowel syndrome (SBS) and associated liver failure are often referred for combined liver/intestinal transplantation. We speculated that in some young children, nutritional autonomy would be possible with restoration of normal liver functi ... Full text Link to item Cite

Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease.

Journal Article Am J Transplant · June 2006 Inflammatory bowel disease (IBD) is associated with primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) and can recur or develop de novo after orthotopic liver transplantation (OLT). The aim of this study was to investigate the incidence an ... Full text Link to item Cite

Cost and quality of life after intestinal transplantation.

Journal Article Gastroenterology · February 2006 Intestinal transplantation has become a standard treatment for intestinal failure in patients with life-threatening complications of TPN. Although the long-term survival of patients with continued parenteral nutrition is higher than after intestinal transp ... Full text Link to item Cite

Predicting outcome of procedures to slow intestinal transit.

Journal Article Transplant Proc · 2006 Procedures designed to slow intestinal transit in patients with the short-bowel syndrome (SBS) have unpredictable outcomes. Our aim was to evaluate the outcome and predictive factors for this complication in SBS patients. Ten patients (37-61 years) underwe ... Full text Link to item Cite

Living and deceased donor liver transplantation for unresectable hepatoblastoma at a single center.

Journal Article Clin Transplant · December 2005 Hepatoblastoma (HB) is the most common malignant liver tumor in children. The application of living donor liver transplantation (LDLT) in the management of unresectable HB may add new therapeutic opportunities. We evaluated the outcomes of patients who und ... Full text Link to item Cite

Low-dose chemotherapy for Epstein-Barr virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation.

Journal Article J Clin Oncol · September 20, 2005 PURPOSE: To evaluate the efficacy of a low-dose chemotherapy regimen in children with Epstein-Barr virus (EBV) -positive, post-transplantation lymphoproliferative disease (PTLD) after organ transplantation who have experienced failure with front-line thera ... Full text Link to item Cite

Postoperative short bowel syndrome.

Journal Article J Am Coll Surg · July 2005 BACKGROUND: Unanticipated massive resection after intraabdominal procedures is an increasing cause of short bowel syndrome (SBS). Our aim was to determine the frequency and potential mechanisms of postoperative SBS. STUDY DESIGN: We reviewed retrospectivel ... Full text Link to item Cite

Small bowel transplantation: Current status and new developments in allograft monitoring

Journal Article Current Opinion in Organ Transplantation · June 1, 2005 Purpose of review: This review aims to summarize the current practices for intestinal allograft monitoring, including the newest developments in the past year. The gold standard has been histologic examination of endoscopy-directed allograft biopsy. Recent ... Full text Cite

A multidisciplinary approach to the treatment of intestinal failure.

Journal Article J Gastrointest Surg · February 2005 Intestinal failure is most commonly treated by the administration of total parenteral nutrition (TPN). In some patients, however, surgical therapy may increase the ability to use the intestine for nutrition and thereby decrease the complications of TPN the ... Full text Link to item Cite

Gallbladder pathology in morbid obesity.

Journal Article Obes Surg · February 2005 BACKGROUND: Obese patients are at increased risk for biliary disease. The prevalence and type of gallbladder pathology in morbidly obese patients was evaluated, and compared with a non-obese control group. METHODS: A consecutive series of obese patients (n ... Full text Link to item Cite

Quality of Life after Intestinal Transplantation

Journal Article Progress in Transplantation · December 2004 As technology introduces more advanced therapies, individuals have realized that quantity or length of life may not always be the ultimate goal in treating disease. The quality of life at times is as important as length of life. In this article, w ... Full text Cite

Short bowel syndrome after trauma.

Journal Article Am J Surg · December 2004 PURPOSE: Traumatic injury to the intestine and its vasculature is a potential cause of short bowel syndrome (SBS). Our aim was to determine the incidence and mechanisms of traumatic injury to the bowel resulting in massive resection. METHODS: We reviewed t ... Full text Link to item Cite

Quality of life after intestinal transplantation.

Journal Article Prog Transplant · December 2004 As technology introduces more advanced therapies, individuals have realized that quantity or length of life may not always be the ultimate goal in treating disease. The quality of life at times is as important as length of life. In this article, we review ... Full text Link to item Cite

Portosystemic shunts in children: a 15-year experience.

Journal Article J Am Coll Surg · August 2004 BACKGROUND: The role of portosystemic shunt (PSS) in children with portal hypertension has changed because of acceptance of liver transplantation and endoscopic hemostasis. We report our experience with PSS, mainly the distal splenorenal shunt, to define i ... Full text Link to item Cite

Quality of life after pediatric intestinal transplantation: the perception of pediatric recipients and their parents.

Journal Article Am J Transplant · March 2004 The objective was to examine the perception of physical and psychosocial functioning of pediatric intestinal transplant recipients who are beyond the perioperative period and compare these with normal and chronically ill children. Child and parent forms of ... Full text Link to item Cite

Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency.

Journal Article Blood · February 1, 2004 The syndrome of multiple intestinal atresia with immunodeficiency is a rare, invariably fatal congenital disorder. At 16 months of age, a child with this syndrome underwent liver-small bowel transplantation from a 1-of-6 HLA-matched donor. He acquired full ... Full text Link to item Cite

Should hepatocellular carcinoma be treated during the waiting list period?

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2004 Link to item Cite

Acute Budd-Chiari syndrome during pregnancy: surgical treatment and orthotopic liver transplantation with successful completion of the pregnancy.

Journal Article Liver Transpl · September 2003 A 26-year-old woman presented with acute Budd-Chiari syndrome 18 weeks into a pregnancy. She was found to be heterozygous for the G20210A prothrombin gene mutation. She was treated with portacaval shunt placement and successfully completed the pregnancy, w ... Full text Link to item Cite

[title field missing]

Journal Article Annals of Surgery · February 1, 2003 Full text Cite

Heart xenograft survival with chimeric pig donors and modest immune suppression.

Journal Article Ann Surg · February 2003 OBJECTIVE: To assess the use of donor pigs with cellular chimerism for prevention of acute rejection with modest immune suppression. The clinical use of pig organ xenografts is currently precluded by severe acute rejection, which resists standard immune su ... Full text Link to item Cite

Bronchoscopy in Liver Transplant Patient

Journal Article Chest · January 2003 Full text Cite

Pre-transplant analysis of accommodation in donor pigs.

Journal Article Xenotransplantation · January 2003 Accommodation could lead to xenograft acceptance without the need for severe immune suppression. Generally graft accommodation is appreciated in the sensitized recipient, after transplantation. By inducing accommodation in chimeric donors, however, the ris ... Full text Link to item Cite

Long-term outcomes in small bowel transplantation: Survival, nutrition, growth, and quality of life

Journal Article Current Opinion in Organ Transplantation · January 1, 2003 Traditional outcomes for transplant recipients include patient and graft survival. Currently, patient survival is between 60 and 75% at 1 year, which is dramatically improved since the introduction of intestinal transplantation just over 1 decade ago. Earl ... Full text Cite

Radiochemotherapy and transplantation allow long-term survival for nonresectable hilar cholangiocarcinoma.

Journal Article Am J Transplant · September 2002 Results of liver transplantation in the treatment of cholangiocarcinoma have been poor as a result of the high incidence of locoregional dissemination and tumor recurrence. This study evaluates the effect of neoadjuvant chemoradiation therapy combined with ... Full text Link to item Cite

Nutritional outcome and growth of children after intestinal transplantation.

Journal Article J Pediatr Surg · March 2002 PURPOSE: The aim of this study was to determine nutritional outcome and growth in children after successful intestinal transplantation. METHODS: Case-record review was conducted of all children who underwent intestinal transplantation at a single center an ... Full text Link to item Cite

Isolated liver transplantation in infants with end-stage liver disease associated with short bowel syndrome.

Journal Article Ann Surg · March 2002 OBJECTIVE: To evaluate experience with isolated orthotopic liver transplantation in children with liver failure associated with short bowel syndrome (SBS). SUMMARY BACKGROUND DATA: Infants who have liver failure as a result of SBS are frequently referred f ... Full text Link to item Cite

Omeprozole therapy in pediatric patients after liver and intestinal transplantation.

Journal Article J Pediatr Gastroenterol Nutr · February 2002 BACKGROUND: Proton pump inhibitors such as omeprazole are increasingly used to prevent stress-related gastric bleeding in critically ill patients. In this investigation, the acid-suppressive potency of omeprazole was assessed in one at-risk group, pediatri ... Full text Link to item Cite

Late graft loss and long-term outcome after isolated intestinal transplantation in children.

Journal Article J Pediatr Surg · February 2002 BACKGROUND/PURPOSE: The aim of this study was to determine causes of late graft loss and long-term outcome after isolated intestinal transplantation in children at a single center. METHODS: All children who underwent primary isolated intestinal transplanta ... Full text Link to item Cite

Small bowel transplantation: Who, when, where, and what organs?

Journal Article Clinical Perspectives in Gastroenterology · January 1, 2002 Small bowel transplantation has become standard therapy for patients with life-threatening complications from total parenteral nutrition (TPN). In some patients the small intestine may be transplanted alone. Combined liver and small bowel transplantation i ... Cite

A new technique for combined liver/small intestinal transplantation.

Journal Article Transplantation · December 15, 2001 The most common application of small bowel transplantation is for the patient with parenteral nutrition-induced liver failure. In this setting, the small intestine is transplanted simultaneously with the liver. We identified three technical problems that w ... Full text Link to item Cite

Treatment of multiple aneurysms of the splenic artery after liver transplantation by percutaneous embolization and laparoscopic splenectomy.

Journal Article Transplantation · September 15, 2001 A high incidence of aneurysms of the splenic artery is found in liver transplant patients. Their significance is related to the risk of rupture, particularly in the postoperative period. Classically, their management is surgical, with ligation or resection ... Full text Link to item Cite

Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection.

Journal Article Transplantation · April 27, 2001 INTRODUCTION: The enterocyte-specific protein, intestinal fatty acid binding protein (I-FABP), is detectable in serum only after intestinal injury. Previous studies in animals suggest that I-FABP might be a useful marker of intestinal allograft rejection. ... Full text Link to item Cite

Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation.

Journal Article Transplantation · April 15, 2001 BACKGROUND: Lipoatrophic diabetes is an insulin resistance syndrome characterized by the complete or partial lack of adipose tissue and disturbances in lipid and glucose metabolism. Nonalcoholic steatohepatitis (NASH) is a well-described change in liver pa ... Full text Link to item Cite

Long-term results of intestinal transplantation for pseudo-obstruction in children.

Journal Article J Pediatr Surg · January 2001 PURPOSE: The aim of this study was to determine long-term results of intestinal transplantation in children with pseudo-obstruction, particularly when stomach and colon are not part of the allograft. METHODS: The authors conducted a case-record review of a ... Full text Link to item Cite

Extracorporeal liver perfusion using human and pig livers for acute liver failure.

Journal Article Transplantation · November 27, 2000 BACKGROUND: Patients with fulminant hepatic failure (FHF) often die awaiting liver transplantation. Extracorporeal liver perfusion (ECLP) has been proposed as a method of "bridging" such patients to transplantation. We report the largest experience to date ... Full text Link to item Cite

Intestinal transplantation: a single-center experience.

Journal Article Transplant Proc · September 2000 Full text Link to item Cite

Isolated intestinal transplantation for intestinal failure

Journal Article The American Journal of Gastroenterology · June 2000 Full text Cite

Isolated intestinal transplantation for intestinal failure.

Journal Article Am J Gastroenterol · June 2000 OBJECTIVE: Parenteral nutrition sustains life in patients with intestinal failure. However, some experience life-threatening complications from parenteral nutrition, and in these individuals intestinal transplantation may be lifesaving. METHODS: This is a ... Full text Link to item Cite

Long-term outcome of simultaneous kidney-pancreas transplantation: analysis of 61 patients with more than 5 years follow-up.

Journal Article Transplantation · February 27, 2000 BACKGROUND: The long-term outcome of simultaneous kidney pancreas transplant recipients is not well established. METHODS: We retrospectively reviewed all patients who underwent simultaneous kidney-pancreas transplantation with bladder drainage at our cente ... Full text Link to item Cite

Disaccharidase activities and fat assimilation in pediatric patients after intestinal transplantation.

Journal Article Transplantation · February 15, 2000 BACKGROUND: Intestinal transplantation has become an accepted therapy for short bowel syndrome and other types of intestinal failure. In order to assess digestive capabilities and feeding practices in a group of 22 pediatric patients after intestinal trans ... Full text Link to item Cite

Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts.

Journal Article Transplantation · January 27, 2000 BACKGROUND: Organ xenografts are fulminantly rejected by antibody-mediated vascular rejection. Surrogate tolerogenesis (ST), the induction of tolerance within the donor, is effective with aorta xenografts. This preliminary study assesses the effect of ST o ... Full text Link to item Cite

Liver and small bowel transplantation: therapeutic alternatives for the treatment of liver disease and intestinal failure.

Journal Article Semin Liver Dis · 2000 Intestinal transplantation is an established life-saving therapy for parenteral nutrition dependent patients suffering from severe complications of parenteral nutrition. Improvements in outcomes over the last decade have occurred with refinements in surgic ... Full text Link to item Cite

Infectious complications after transplantation

Journal Article Problems in General Surgery · October 21, 1998 Infection is one of the most common complications after solid organ transplantation. Patients awaiting transplantation are often quite debilitated from their disease, increasing the risk of infection and other complications during transplantation. Patients ... Cite

Correlation of mucosal disaccharidase activities with histology in evaluation of rejection following intestinal transplantation.

Journal Article Pediatr Transplant · May 1998 Following intestinal transplantation, we have found that recovery from severe rejection may be difficult to identify. In this study we sought to ascertain whether concurrent determination of mucosal disaccharidase activities and histologic assessment impro ... Link to item Cite

Protein kinase C isoforms in human aortic smooth muscle cells.

Journal Article J Vasc Surg · May 1998 PURPOSE: To identify the protein kinase C (PKC) isoforms in human arterial smooth muscle cells (SMC) and define their subcellular location in the resting state and in response to the PKC activator, 12-O-tetradecanoylphorbol 13-acetate (TPA). METHODS: Arter ... Full text Link to item Cite

Biliary atresia-polysplenia syndrome: surgical and clinical relevance in liver transplantation.

Journal Article Ann Surg · April 1998 OBJECTIVE: To review a single center's 10-year experience with liver transplantation (LTx) for the biliary atresia-polysplenia syndrome (BA-PS) and to define surgical and clinical guidelines for its management. SUMMARY BACKGROUND DATA: BA is the most commo ... Full text Link to item Cite

Causes of late mortality in pediatric liver transplant recipients.

Journal Article Ann Surg · February 1998 OBJECTIVE: This study was undertaken to review the incidence and causes of death in children who have survived long-term (more than 1 year) after liver transplantation (LT). SUMMARY BACKGROUND DATA: No studies of the causes of late mortality in pediatric L ... Full text Link to item Cite

A COMPARISON OF PEDIATRIC LIVER TRANSPLANT PATIENTS RECEIVING LIVE DONOR OR CADAVERIC ALLOGRAFTS

Journal Article Journal of Pediatric Gastroenterology and Nutrition · January 1, 1998 Full text Cite

Retransplantation in the diabetic patient with a pancreas allograft.

Journal Article Am J Surg · December 1997 BACKGROUND: Retransplantation has been considered a risk factor for both postoperative complications and diminished graft survival, especially in diabetic patients. METHODS: A retrospective survey was performed of a consecutive case series of 196 pancreas ... Full text Link to item Cite

Long-term follow-up of auxiliary orthotopic liver transplantation for the treatment of fulminant hepatic failure.

Journal Article Surgery · October 1997 BACKGROUND: Auxiliary orthotopic liver transplantation (AOLT) was investigated as a bridge to native liver recovery in patients with fulminant hepatic failure (FHF). METHODS: In the last 5 years seven patients with FHF were treated with AOLT at our institu ... Full text Link to item Cite

Surgical treatment of large hepatic adenomas.

Conference HEPATOLOGY · October 1, 1997 Link to item Cite

The role of liver transplantation in the management of portal hypertension.

Journal Article Clin Liver Dis · May 1997 Liver transplantation is the treatment of choice for end stage liver disease and not a treatment specifically for portal hypertension. A patient with complications of portal hypertension must be evaluated for the presence, etiology, and severity of liver d ... Full text Link to item Cite

Bench reconstruction of pancreas for transplantation: experience with 192 cases.

Journal Article Clin Transplant · April 1997 UNLABELLED: Whole organ pancreaticoduodenal transplantation with bladder drainage by the duodenal segment technique is currently the preferred method of vascularized pancreas transplantation but is associated with a finite risk of surgical complications. M ... Link to item Cite

Solitary pancreas transplantation. Experience with 62 consecutive cases.

Journal Article Diabetes Care · March 1997 OBJECTIVE: To determine the safety and efficacy of solitary pancreas transplantation in the treatment of IDDM. RESEARCH DESIGN AND METHODS: A single-center retrospective case series of 62 consecutive solitary pancreas transplants (20 sequential pancreas af ... Full text Link to item Cite

Experience with enteric conversion after pancreatic transplantation with bladder drainage.

Journal Article J Am Coll Surg · March 1997 BACKGROUND: Bladder drainage by the duodenal segment technique is currently the preferred method of handling the exocrine secretions after vascularized pancreatic transplantation. Despite improving results, however, the management of metabolic and urologic ... Link to item Cite

Duodenal segment complications in vascularized pancreas transplantation.

Journal Article J Gastrointest Surg · 1997 Bladder drainage by the duodenal segment (DS) technique is currently the preferred method of pancreas transplantation (PTX) but is associated with unique complications. Over a 7-year period, 191 diabetic patients underwent 201 whole-organ PTXs with bladder ... Full text Link to item Cite

Analysis of early readmissions after combined pancreas-kidney transplantation.

Journal Article Am J Kidney Dis · December 1996 Combined pancreas-kidney transplantation (PKT) has become generally accepted as an effective treatment option, but controversy exists regarding the early morbidity rate of the procedure. To address this issue, we retrospectively analyzed all readmissions o ... Full text Link to item Cite

Digestive function following intestinal transplantation.: Intestinal transplantation

Journal Article Journal of Pediatric Gastroenterology and Nutrition · January 1, 1996 Full text Cite

Experience with protocol biopsies after solitary pancreas transplantation.

Journal Article Transplantation · December 27, 1995 The early detection of allograft rejection remains elusive after solitary pancreas transplantation (PTX). We have previously described a modified technique of cystoscopic transduodenal PTX biopsy using the Biopty gun under ultrasound guidance. During the l ... Full text Link to item Cite

Experience with pancreas retransplantation.

Journal Article Transplant Proc · December 1995 Link to item Cite

Infection prophylaxis in pancreas transplant recipients.

Journal Article Transplant Proc · December 1995 Link to item Cite

Book Review

Journal Article The American Journal of Surgery · September 1995 Full text Cite

Pancreas transplantation: the Nebraska experience.

Journal Article Clin Transpl · 1994 In summary, we believe that combined PKT can be performed safely and effectively in the absence of uremia, thereby providing the potential for arresting the progression of diabetic complications prior to the development of ESRD. Furthermore, performing sol ... Link to item Cite

Colonoscopic indirect lymphangiography in a canine model.

Journal Article Surg Endosc · 1993 Colorectal malignancies metastasize most frequently to mesenteric lymph nodes. Preoperative staging of these nodes by current modalities is problematic. This study evaluates the feasibility of indirect mesenteric lymphangiography as a colonoscopic techniqu ... Full text Link to item Cite

Colonoscopic indirect lymphangiography.

Journal Article Gastrointest Endosc · 1993 Full text Link to item Cite