Scholars@Duke
Elizabeth Ray DeLong

Elizabeth Ray DeLong

Professor Emeritus of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
delon001@mc.duke.edu
Duke Box 2721, Durham, NC 27710
11072 Hock Plaza, Durham, NC 27710

Selected Publications

Empirical use of causal inference methods to evaluate survival differences in a real-world registry vs those found in randomized clinical trials.

Journal Article Stat Med · September 30, 2020 With heighted interest in causal inference based on real-world evidence, this empirical study sought to understand differences between the results of observational analyses and long-term randomized clinical trials. We hypothesized that patients deemed "eli ... Full text Link to item Cite

I-CARE randomized clinical trial integrating depression and acute coronary syndrome care in low-resource hospitals in China: Design and rationale.

Journal Article Am Heart J · August 2018 Depression and acute coronary syndromes (ACS) are both common public health challenges. Patients with ACS often develop depression, which in turn adversely affects prognosis. Low-cost, sustainable, and effective service models that integrate depression car ... Full text Link to item Cite

An evaluation of constrained randomization for the design and analysis of group-randomized trials with binary outcomes.

Journal Article Stat Med · October 30, 2017 Group-randomized trials are randomized studies that allocate intact groups of individuals to different comparison arms. A frequent practical limitation to adopting such research designs is that only a limited number of groups may be available, and therefor ... Full text Link to item Cite

Statistical lessons learned for designing cluster randomized pragmatic clinical trials from the NIH Health Care Systems Collaboratory Biostatistics and Design Core.

Journal Article Clin Trials · October 2016 BACKGROUND/AIMS: Pragmatic clinical trials embedded within health care systems provide an important opportunity to evaluate new interventions and treatments. Networks have recently been developed to support practical and efficient studies. Pragmatic trials ... Full text Link to item Cite

An evaluation of constrained randomization for the design and analysis of group-randomized trials.

Journal Article Stat Med · May 10, 2016 In group-randomized trials, a frequent practical limitation to adopting rigorous research designs is that only a small number of groups may be available, and therefore, simple randomization cannot be relied upon to balance key group-level prognostic factor ... Full text Link to item Cite

Evaluating Academic Scientists Collaborating in Team-Based Research: A Proposed Framework.

Journal Article Acad Med · October 2015 Criteria for evaluating faculty are traditionally based on a triad of scholarship, teaching, and service. Research scholarship is often measured by first or senior authorship on peer-reviewed scientific publications and being principal investigator on extr ... Full text Link to item Cite

Composite outcomes in coronary bypass surgery versus percutaneous intervention.

Journal Article Ann Thorac Surg · June 2014 BACKGROUND: Recent observational studies show that patients with multivessel coronary disease have a long-term survival advantage with coronary artery bypass grafting (CABG) compared with percutaneous coronary intervention (PCI). Important nonfatal outcome ... Full text Link to item Cite

Population impact of a high cardiovascular risk management program delivered by village doctors in rural China: design and rationale of a large, cluster-randomized controlled trial.

Journal Article BMC Public Health · April 11, 2014 BACKGROUND: The high-risk strategy has been proven effective in preventing cardiovascular disease; however, the population benefits from these interventions remain unknown. This study aims to assess, at the population level, the effects of an evidence-base ... Full text Open Access Link to item Cite

Angiographic validation of the American College of Cardiology Foundation-the Society of Thoracic Surgeons Collaboration on the Comparative Effectiveness of Revascularization Strategies study.

Journal Article Circ Cardiovasc Interv · February 2014 BACKGROUND: The goal of this study was to compare angiographic interpretation of coronary arteriograms by sites in community practice versus those made by a centralized angiographic core laboratory. METHODS AND RESULTS: The study population consisted of 20 ... Full text Link to item Cite

Predictors of long-term survival after coronary artery bypass grafting surgery: results from the Society of Thoracic Surgeons Adult Cardiac Surgery Database (the ASCERT study).

Journal Article Circulation · March 27, 2012 BACKGROUND: Most survival prediction models for coronary artery bypass grafting surgery are limited to in-hospital or 30-day end points. We estimate a long-term survival model using data from the Society of Thoracic Surgeons Adult Cardiac Surgery Database ... Full text Link to item Cite

Prediction of long-term mortality after percutaneous coronary intervention in older adults: results from the National Cardiovascular Data Registry.

Journal Article Circulation · March 27, 2012 BACKGROUND: The purpose of this study was to develop a long-term model to predict mortality after percutaneous coronary intervention in both patients with ST-segment elevation myocardial infarction and those with more stable coronary disease. METHODS AND R ... Full text Link to item Cite

ACCF/AHA methodology for the development of quality measures for cardiovascular technology: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures.

Journal Article Circulation · September 27, 2011 Consistent with the growing national focus on healthcare quality, the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) have taken a leadership role over the past decade in developing measures of the quality of cardi ... Full text Link to item Cite

ACCF/AHA methodology for the development of quality measures for cardiovascular technology: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures.

Journal Article J Am Coll Cardiol · September 27, 2011 Consistent with the growing national focus on healthcare quality, the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) have taken a leadership role over the past decade in developing measures of the quality of cardi ... Full text Link to item Cite

Secondary prevention after coronary artery bypass graft surgery: findings of a national randomized controlled trial and sustained society-led incorporation into practice.

Journal Article Circulation · January 4, 2011 BACKGROUND: Despite evidence supporting the use of aspirin, β-blockers, angiotensin-converting enzyme inhibitors, and lipid-lowering therapies in eligible patients, adoption of these secondary prevention measures after coronary artery bypass grafting has b ... Full text Link to item Cite

Delay from symptom onset to hospital presentation for patients with non-ST-segment elevation myocardial infarction.

Journal Article Arch Intern Med · November 8, 2010 BACKGROUND: Secular trends and factors associated with delay time from symptom onset to hospital presentation are known for patients with ST-segment elevation myocardial infarction (STEMI) but are less well-described for non-STEMI. METHODS: We studied 104 ... Full text Link to item Cite

Contemporary mortality risk prediction for percutaneous coronary intervention: Results from 588, 398 procedures in the national cardiovascular data registry

Journal Article Revista Portuguesa de Cardiologia · November 1, 2010 Objectives: We sought to create contemporary models for predicting mortality risk following percutaneous coronary intervention (PCI). Background: There is a need to identifiy PCI risk factors and accurately quantify procedural risks to facilitate comparati ... Cite

Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.

Journal Article Am Heart J · September 2010 BACKGROUND: Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification. METHODS: Horizon 1 of the Measurement to Understand the Reclassification of Disea ... Full text Link to item Cite

Contemporary mortality risk prediction for percutaneous coronary intervention: results from 588,398 procedures in the National Cardiovascular Data Registry.

Journal Article J Am Coll Cardiol · May 4, 2010 OBJECTIVES: We sought to create contemporary models for predicting mortality risk following percutaneous coronary intervention (PCI). BACKGROUND: There is a need to identify PCI risk factors and accurately quantify procedural risks to facilitate comparativ ... Full text Link to item Cite

Influence of clinical trial participation on subsequent antithrombin use.

Journal Article Clin Cardiol · March 2010 BACKGROUND: Results from the Superior Yield of the New Strategy of Enoxaparin, Revascularization, and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial showed that the low-molecular-weight heparin (LMWH) enoxaparin was non-inferior compared with unfractiona ... Full text Link to item Cite

Reprint-AACVPR/ACCF/AHA 2010 update: Performance measures on cardiac rehabilitation for referral to cardiac rehabilitation/secondary prevention services

Journal Article Physical Therapy · January 1, 2010 Endorsed by the American College of Chest Physicians, the American College of Sports Medicine, the American Physical Therapy Association, the Canadian Association of Cardiac Rehabilitation, the European Association for Cardiovascular Prevention and Rehabil ... Full text Cite

Hypercholesterolemia paradox in relation to mortality in acute coronary syndrome.

Journal Article Clin Cardiol · September 2009 Featured Publication BACKGROUND: Hypercholesterolemia is a risk factor for coronary artery disease, yet is associated with lower risk of adverse outcomes in patients with acute coronary syndromes (ACS). HYPOTHESIS: We explored this paradox in 84,429 patients with non-ST-segmen ... Full text Link to item Cite

Assessing the economic attractiveness of coronary artery revascularization in chronic kidney disease patients.

Journal Article J Med Syst · August 2009 Featured Publication Chronic kidney disease (CKD) is associated with increased morbidity and mortality in coronary artery disease (CAD) patients. We compared the economic attractiveness of CAD revascularization procedures in patients with and without CKD. Our population includ ... Full text Link to item Cite

The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 1--coronary artery bypass grafting surgery.

Journal Article Ann Thorac Surg · July 2009 Featured Publication BACKGROUND: The first version of The Society of Thoracic Surgeons National Adult Cardiac Surgery Database (STS NCD) was developed nearly 2 decades ago. Since its inception, the number of participants has grown dramatically, patient acuity has increased, an ... Full text Link to item Cite

The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2--isolated valve surgery.

Journal Article Ann Thorac Surg · July 2009 Featured Publication BACKGROUND: Adjustment for case-mix is essential when using observational data to compare surgical techniques or providers. That is most often accomplished through the use of risk models that account for preoperative patient factors that may impact outcome ... Full text Link to item Cite

The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 3--valve plus coronary artery bypass grafting surgery.

Journal Article Ann Thorac Surg · July 2009 Featured Publication BACKGROUND: Since 1999, The Society of Thoracic Surgeons (STS) has published two risk models that can be used to adjust the results of valve surgery combined with coronary artery bypass graft surgery (CABG). The most recent was developed from data for pati ... Full text Link to item Cite

Strategies for analyzing multilevel cluster-randomized studies with binary outcomes collected at varying intervals of time.

Journal Article Stat Med · December 20, 2008 Featured Publication Frequently, studies are conducted in a real clinic setting. When the outcome of interest is collected longitudinally over a specified period of time, this design can lead to unequally spaced intervals and varying numbers of assessments. In our study, these ... Full text Link to item Cite

ACC/AHA classification of care metrics: performance measures and quality metrics: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.

Journal Article J Am Coll Cardiol · December 9, 2008 The American College of Cardiology (ACC) and the American Heart Association (AHA) have provided leadership in enhancing the quality of cardiovascular care, including the development of clinical performance measures and clinical registries that permit the e ... Full text Link to item Cite

ACC/AHA classification of care metrics: performance measures and quality metrics: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures.

Journal Article Circulation · December 9, 2008 The American College of Cardiology (ACC) and the American Heart Association (AHA) have provided leadership in enhancing the quality of cardiovascular care, including the development of clinical performance measures and clinical registries that permit the e ... Full text Link to item Cite

Patterns of transfer for patients with non-ST-segment elevation acute coronary syndrome from community to tertiary care hospitals.

Journal Article Am Heart J · July 2008 Featured Publication BACKGROUND: Practice guidelines for non-ST-segment elevation acute coronary syndromes (NSTE ACS) recommend early invasive management (cardiac catheterization and revascularization within 48 hours of hospital presentation) for high-risk patients, but interh ... Full text Link to item Cite

Impact of case volume on hospital performance assessment.

Journal Article Arch Intern Med · June 23, 2008 Featured Publication BACKGROUND: Process performance measures are increasingly used to assess and reward hospital quality. The impact of small hospital case volumes on such measures is not clear. METHODS: Using data from the Hospital Quality Alliance, we examined hospital perf ... Full text Link to item Cite

Exploring the behavior of hospital composite performance measures: an example from coronary artery bypass surgery.

Journal Article Circulation · December 18, 2007 Featured Publication BACKGROUND: Composite scores that combine several performance measures into a single ranking are becoming the accepted metric for assessing hospital performance. In particular, the Centers for Medicare & Medicaid Services Hospital Quality Incentive Demonst ... Full text Link to item Cite

Pay for performance, quality of care, and outcomes in acute myocardial infarction.

Journal Article JAMA · June 6, 2007 Featured Publication CONTEXT: Pay for performance has been promoted as a tool for improving quality of care. In 2003, the Centers for Medicare & Medicaid Services (CMS) launched the largest pay-for-performance pilot project to date in the United States, including indicators fo ... Full text Link to item Cite

Is early too early? Effect of shorter stays after bypass surgery.

Journal Article Ann Thorac Surg · January 2007 Featured Publication BACKGROUND: Postoperative stays after coronary artery bypass graft surgery (CABG) decreased substantially in the 1990s. Although shorter stays offer clinical benefits, premature discharge could increase adverse events and offset initial savings. This study ... Full text Link to item Cite

Trends in postoperative length of stay after bypass surgery.

Journal Article Am Heart J · December 2006 Featured Publication BACKGROUND: Although single-site studies have reported reductions in coronary artery bypass graft (CABG) surgery length of stay (LOS) over the last 15 years, less information is available regarding overall temporal trends and interhospital variability. Thi ... Full text Link to item Cite

Insurance coverage and care of patients with non-ST-segment elevation acute coronary syndromes.

Journal Article Ann Intern Med · November 21, 2006 Featured Publication BACKGROUND: The impact of insurance coverage on the care of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) is unclear. OBJECTIVE: To compare NSTE ACS care patterns by insurance type. DESIGN: Comparison of Medicaid patients young ... Full text Link to item Cite

Selection of surgical or percutaneous coronary intervention provides differential longevity benefit.

Journal Article Ann Thorac Surg · October 2006 Featured Publication BACKGROUND: Treatment of coronary artery disease (CAD) is evolving with better medications, improvements in percutaneous coronary intervention (PCI), and enhanced techniques for coronary artery bypass grafting (CABG). METHODS: In this study, 18,481 patient ... Full text Link to item Cite

Multifaceted intervention to promote beta-blocker use in heart failure.

Journal Article Am Heart J · May 2006 Featured Publication BACKGROUND: Despite a survival benefit and guideline recommendation for beta-blockers in left ventricular systolic dysfunction, beta-blockers are underused in clinical practice. METHODS: Medical practices with > or = 15 patients with heart failure (HF) in ... Full text Link to item Cite

How obesity affects the cut-points for B-type natriuretic peptide in the diagnosis of acute heart failure. Results from the Breathing Not Properly Multinational Study.

Journal Article Am Heart J · May 2006 BACKGROUND: B-type natriuretic peptide (BNP) is valuable in diagnosing heart failure (HF), but its utility in obese patients is unknown. Studies have suggested a cut-point of BNP > or = 100 pg/mL for the diagnosis of HF; however, there is an inverse relati ... Full text Link to item Cite

Association between hospital process performance and outcomes among patients with acute coronary syndromes.

Journal Article JAMA · April 26, 2006 Featured Publication CONTEXT: Selected care processes are increasingly being used to measure hospital quality; however, data regarding the association between hospital process performance and outcomes are limited. OBJECTIVES: To evaluate contemporary care practices consistent ... Full text Link to item Cite

Determinants of operative mortality in valvular heart surgery.

Journal Article J Thorac Cardiovasc Surg · March 2006 Featured Publication OBJECTIVE: In some respects, outcome reporting in valvular surgery has been hampered by focusing on specific populations, reluctance to publish high-risk subgroups, and possibly skewed or inadequate samples. The goal of this study was to evaluate risk fact ... Full text Link to item Cite

Long-term adherence to evidence-based secondary prevention therapies in coronary artery disease.

Journal Article Circulation · January 17, 2006 Featured Publication BACKGROUND: Studies have examined the use of evidence-based therapies for coronary artery disease (CAD) in the short term and at hospital discharge, but few have evaluated long-term use. METHODS AND RESULTS: Using the Duke Databank for Cardiovascular Disea ... Full text Link to item Cite

Detecting pheochromocytoma: defining the most sensitive test.

Journal Article Ann Surg · January 2006 Featured Publication OBJECTIVE: To define the most sensitive biochemical test to establish the diagnosis of pheochromocytoma and also to assess the potential role of iodine 131-labeled metaiodobenzylguanidine scintigraphy (I-MIBG) in the diagnosis of this tumor. SUMMARY BACKGR ... Full text Link to item Cite

The evaluation of treatment when center-specific selection criteria vary with respect to patient risk.

Journal Article Biometrics · December 2005 Featured Publication Many standards of medical care are based on the demonstrated effects of various treatment strategies or processes. Unlike pharmacological treatments, these strategies or processes are not necessarily subjected to rigorous clinical trials and their benefit ... Full text Link to item Cite

Optimal timing of intervention in non-ST-segment elevation acute coronary syndromes: insights from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) Registry.

Journal Article Circulation · November 15, 2005 Featured Publication BACKGROUND: Recent studies indicate that a routine invasive approach for patients with unstable angina (UA) and non-ST-segment elevation myocardial infarction (NSTEMI) yields improved outcomes compared with a conservative approach, but the optimal timing o ... Full text Link to item Cite

Prognostic/Clinical Prediction Models: Using Observational Data to Estimate Prognosis: An Example Using a Coronary Artery Disease Registry

Chapter · August 24, 2005 With the proliferation of clinical data registries and the rising expense of clinical trials, observational data sources are increasingly providing evidence for clinical decision making. These data are viewed as complementary to randomized clinical trials ... Full text Cite

Predicting risk-adjusted mortality for CABG surgery: logistic versus hierarchical logistic models.

Journal Article Med Care · July 2005 Featured Publication BACKGROUND: In recent years, several studies in the medical and health service research literature have advocated the use of hierarchical statistical models (multilevel models or random-effects models) to analyze data that are nested (eg, patients nested w ... Full text Link to item Cite

Influence of racial disparities in procedure use on functional status outcomes among patients with coronary artery disease.

Journal Article Circulation · March 15, 2005 Featured Publication BACKGROUND: Although black cardiac patients receive fewer revascularization procedures than whites, it is unclear whether this has a detrimental impact on outcomes. The objective of our study was to compare 6-month functional status and angina outcomes amo ... Full text Link to item Cite

Research, managed care, and patient privacy: Challenges to successful collaboration

Journal Article Journal of Clinical Outcomes Management · March 1, 2005 • Objective: To illustrate the impact of increased patient privacy concerns on the conduct of research on managed care patients and to suggest mechanisms for successful collaboration between managed care organizations and academic research organizations. • ... Cite

The relation between angina, treatment and quality of life in cardiac patients

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2005 Link to item Cite

Mortality following blood culture in premature infants: increased with Gram-negative bacteremia and candidemia, but not Gram-positive bacteremia.

Journal Article J Perinatol · March 2004 OBJECTIVE: To describe survival following nosocomial bloodstream infections and quantify excess mortality associated with positive blood culture. STUDY DESIGN: Multicenter cohort study of premature infants. RESULTS: First blood culture was negative for 464 ... Full text Link to item Cite

Interpreting statistics in medical literature: a vade mecum for surgeons.

Journal Article J Am Coll Surg · March 2004 Featured Publication Full text Link to item Cite

Postconception age and other risk factors associated with mortality following Gram-negative rod bacteremia.

Journal Article J Perinatol · March 2004 Featured Publication BACKGROUND: Neonatal nosocomial Gram-negative rod bacteremia (GNR-b) is considered ominous. DESIGN: Multi-center cohort study of premature infants (N=6172) who had a blood culture after day of life 3 and whose birthweight was < or =1250 g. RESULTS: A total ... Full text Link to item Cite

1153-74 Physician counseling can influence health-related quality of life

Conference Journal of the American College of Cardiology · March 2004 Full text Cite

Economic effects of beta-blocker therapy in patients with heart failure.

Journal Article Am J Med · January 15, 2004 Featured Publication PURPOSE: Studies suggest that beta-blockers improve outcomes in heart failure patients and may be cost saving to society. However, many heart failure patients are not treated with beta-blockers. Economic incentives facing hospitals, physicians, payers, and ... Full text Link to item Cite

Procedural volume as a marker of quality for CABG surgery.

Journal Article JAMA · January 14, 2004 Featured Publication CONTEXT: There have been recent calls for using hospital procedural volume as a quality indicator for coronary artery bypass graft (CABG) surgery, but further research into analysis and policy implication is needed before hospital procedural volume is acce ... Full text Link to item Cite

Latent class analysis: an illustrative application for education in the assessment of resident otoscopic skills.

Journal Article Ambul Pediatr · 2004 BACKGROUND: There is no gold standard readily available in several components of the routine physical exam: one example is the otoscopic exam, where the gold standard is confirmation by tympanocentesis. Resident education does not typically include routine ... Full text Link to item Cite

ROC methodology within a monitoring framework.

Journal Article Stat Med · November 30, 2003 Featured Publication Receiver operating characteristic (ROC) methodology is widely used to evaluate and compare diagnostic tests. Generally, each diagnostic test is applied once to each subject in a population and the results, reported on a continuous scale, are used to constr ... Full text Link to item Cite

Evaluation of the dofetilide risk-management program.

Journal Article Am Heart J · November 2003 BACKGROUND: Dose-dependent torsades de pointes has been shown to occur with dofetilide (Tikosyn) and sotalol HCl (Betapace AF); thus, detailed dosing and monitoring recommendations to minimize this risk are included in the product labeling for both drugs. ... Full text Link to item Cite

Empirical therapy for neonatal candidemia in very low birth weight infants.

Journal Article Pediatrics · September 2003 Featured Publication OBJECTIVE: Neonatal candidemia is often fatal. Empirical antifungal therapy is associated with improved survival in neonates and patients with fever and neutropenia. Although guidelines for empirical therapy exist for patients with fever and neutropenia, t ... Full text Link to item Cite

Use of continuous quality improvement to increase use of process measures in patients undergoing coronary artery bypass graft surgery: a randomized controlled trial.

Journal Article JAMA · July 2, 2003 Featured Publication CONTEXT: A rigorous evaluation of continuous quality improvement (CQI) in medical practice has not been carried out on a national scale. OBJECTIVE: To test whether low-intensity CQI interventions can be used to speed the national adoption of 2 coronary art ... Full text Link to item Cite

The Society of Thoracic Surgeons: 30-day operative mortality and morbidity risk models.

Journal Article Ann Thorac Surg · June 2003 Featured Publication BACKGROUND: Although 30 day risk-adjusted operative mortality (ROM) has been used for quality assessment, it is not sufficient to describe the outcomes after coronary artery bypass grafting (CABG) surgery. Risk-adjusted major morbidity may differentially i ... Full text Link to item Cite

Home health care for coronary artery disease patients impacts quality of life

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 19, 2003 Link to item Cite

Hierarchical modeling: its time has come.

Journal Article Am Heart J · January 2003 Full text Link to item Cite

Percutaneous transluminal septal reduction for hypertrophic obstructive cardiomyopathy: report from an international pilot study.

Journal Article J Med Syst · August 2002 Featured Publication Assessing the effectiveness of newer treatments for rare diseases can be challenging because of the small number of patients treated at individual centers. We enrolled patients undergoing percutaneous transluminal septal myocardial ablation (PTSMA) for hyp ... Full text Link to item Cite

Hospital variability in length of stay after coronary artery bypass surgery: results from the Society of Thoracic Surgeon's National Cardiac Database.

Journal Article Ann Thorac Surg · August 2002 Featured Publication BACKGROUND: There is growing interest in comparing resource, as well as patient outcome metrics among coronary artery bypass graft surgery (CABG) providers, yet few tools exist for adjusting these provider comparisons for patient case-mix. In this study, w ... Full text Link to item Cite

Patient-reported frequency of taking aspirin in a population with coronary artery disease.

Journal Article Am J Cardiol · May 1, 2002 Featured Publication Despite the established benefits of antiplatelet agents in coronary artery disease (CAD), many appropriate patients are not receiving them. We investigated the prevalence of and factors associated with aspirin use and nonuse within a large referral populat ... Full text Link to item Cite

Association between pulse pressure and mortality in patients undergoing maintenance hemodialysis.

Journal Article JAMA · March 27, 2002 Featured Publication CONTEXT: Although increased blood pressure is associated with adverse outcomes in the general population, elevated blood pressure is associated with decreased mortality in patients with end-stage renal disease undergoing maintenance hemodialysis. Recent in ... Full text Link to item Cite

Underuse of aspirin in a referral population with documented coronary artery disease.

Journal Article Am J Cardiol · March 15, 2002 Featured Publication Despite substantial evidence that antiplatelet therapy saves lives and reduces adverse events in patients with coronary artery disease (CAD), use of the most widely available and lowest cost antiplatelet agent, aspirin, continues to be disappointingly low. ... Full text Link to item Cite

A decade of change--risk profiles and outcomes for isolated coronary artery bypass grafting procedures, 1990-1999: a report from the STS National Database Committee and the Duke Clinical Research Institute. Society of Thoracic Surgeons.

Journal Article Ann Thorac Surg · February 2002 Featured Publication BACKGROUND: The Society of Thoracic Surgeons National Adult Cardiac Database is the largest voluntary clinical database in medicine. Using this database we examined changes in the risk profile of patients undergoing isolated coronary artery bypass grafting ... Full text Link to item Cite

Variability in cost of coronary bypass surgery in New York State: potential for cost savings.

Journal Article Am Heart J · January 2002 Featured Publication OBJECTIVE: Previous analyses of variability in bypass resource use have not focused on hospital-level variation or adequately explored the influence of patient risk. We combined a clinical database with claims data to fully characterize patient level and h ... Full text Link to item Cite

The impact of statistical adjustment on economic profiles of interventional cardiologists.

Journal Article J Am Coll Cardiol · November 1, 2001 Featured Publication OBJECTIVES: The objective of this study was to identify preprocedure patient factors associated with percutaneous intervention costs and to examine the impact of these patient factors on economic profiles of interventional cardiologists. BACKGROUND: There ... Full text Link to item Cite

Using observational data to estimate prognosis: an example using a coronary artery disease registry.

Journal Article Stat Med · August 30, 2001 Featured Publication With the proliferation of clinical data registries and the rising expense of clinical trials, observational data sources are increasingly providing evidence for clinical decision making. These data are viewed as complementary to randomized clinical trials ... Full text Link to item Cite

Sex differences in neurological outcomes and mortality after cardiac surgery: a society of thoracic surgery national database report.

Journal Article Circulation · May 1, 2001 Featured Publication BACKGROUND: The purpose of this study was to evaluate whether women undergoing cardiac surgery are more likely to suffer neurological complications than men and whether these complications could explain, at least in part, their higher perioperative mortali ... Full text Link to item Cite

Prediction of operative mortality after valve replacement surgery.

Journal Article J Am Coll Cardiol · March 1, 2001 Featured Publication OBJECTIVES: We sought to develop national benchmarks for valve replacement surgery by developing statistical risk models of operative mortality. BACKGROUND: National risk models for coronary artery bypass graft surgery (CABG) have gained widespread accepta ... Full text Link to item Cite

A diagnostic for Cox regression with discrete failure-time models.

Journal Article Biometrics · December 2000 Changes in maximum likelihood parameter estimates due to deletion of individual observations are useful statistics, both for regression diagnostics and for computing robust estimates of covariance. For many likelihoods, including those in the exponential f ... Full text Link to item Cite

Challenges in comparing risk-adjusted bypass surgery mortality results: results from the Cooperative Cardiovascular Project.

Journal Article J Am Coll Cardiol · December 2000 OBJECTIVES: We sought to evaluate the predictive accuracy of four bypass surgery mortality clinical risk models and to examine the extent to which hospitals' risk-adjusted surgical outcomes vary depending on which risk-adjustment method is applied. BACKGRO ... Full text Link to item Cite

31 Statistical applications in cardiovascular disease

Journal Article Handbook of Statistics · December 1, 2000 Full text Cite

Prediction of operative mortality following valve replacement surgery

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2000 Link to item Cite

Determination of the potency of remifentanil compared with alfentanil using ventilatory depression as the measure of opioid effect.

Journal Article Anesthesiology · June 1999 BACKGROUND: Remifentanil is a new opioid with properties similar to other mu-specific agonists. To establish its pharmacologic profile relative to other known opioids, it is important to determine its potency. This study investigated the relative potency o ... Full text Link to item Cite

Acute and long-term cost implications of coronary stenting.

Journal Article J Am Coll Cardiol · May 1999 OBJECTIVES: We compared the acute and one year medical costs and outcomes of coronary stenting with those for balloon angioplasty (percutaneous transluminal coronary angioplasty) in contemporary clinical practice. BACKGROUND: While coronary stent implantat ... Full text Link to item Cite

A comparison of 0.5% bupivacaine, 0.5% ropivacaine, and 0.75% ropivacaine for interscalene brachial plexus block.

Journal Article Anesth Analg · December 1998 UNLABELLED: The onset time and duration of action of ropivacaine during an interscalene block are not known. The potentially improved safety profile of ropivacaine may allow the use of higher concentrations to try and speed onset time. We compared bupivaca ... Full text Link to item Cite

Use of an automated anesthesia information system to determine reference limits for vital signs during cesarean section.

Journal Article J Clin Monit Comput · December 1998 INTRODUCTION: We evaluated whether automated anesthesia information systems can be used to calculate reference limits (population-based "normal values") for vital signs. We considered four populations of women undergoing cesarean section: healthy under spi ... Full text Link to item Cite

Value of exercise treadmill testing in women.

Journal Article J Am Coll Cardiol · November 15, 1998 OBJECTIVES: We sought to determine the ability of a treadmill score to provide accurate diagnostic and prognostic risk estimates in women. BACKGROUND: Treadmill testing has been reported to have a lower accuracy for diagnosis of chest pain in women. The di ... Full text Link to item Cite

Use of a prognostic treadmill score in identifying diagnostic coronary disease subgroups.

Journal Article Circulation · October 20, 1998 BACKGROUND: Exercise testing is useful in the assessment of symptomatic patients for diagnosis of significant or extensive coronary disease and to predict their future risk of cardiac events. The Duke treadmill score (DTS) is a composite index that was des ... Full text Link to item Cite

The effects of New York's bypass surgery provider profiling on access to care and patient outcomes in the elderly.

Journal Article J Am Coll Cardiol · October 1998 OBJECTIVE: The aim of this study was to examine the effects of provider profiling on bypass surgery access and outcomes in elderly patients in New York. BACKGROUND: Since 1989, New York (NY) has compiled provider-specific bypass surgery mortality reports. ... Full text Link to item Cite

Aging profoundly decreases anesthetic requirement

Journal Article ANESTHESIOLOGY · September 1, 1998 Link to item Cite

Economic assessment of low-molecular-weight heparin (enoxaparin) versus unfractionated heparin in acute coronary syndrome patients: results from the ESSENCE randomized trial. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q wave Coronary Events [unstable angina or non-Q-wave myocardial infarction].

Journal Article Circulation · May 5, 1998 BACKGROUND: In the ESSENCE trial, subcutaneous low-molecular-weight heparin (enoxaparin) reduced the 30-day incidence of death, myocardial infarction, and recurrent angina relative to intravenous unfractionated heparin in 3171 patients with acute coronary ... Full text Link to item Cite

Do PTCA Mortality Outcomes Need to Be Risk-adjusted? Results From the National Cardiovascular Network (NCN)

Journal Article Journal of the American College of Cardiology · February 1998 Full text Cite

Predicting Mortality Following PTCA: Results From NCN

Journal Article Journal of the American College of Cardiology · February 1998 Full text Cite

Comparing risk-adjustment methods for provider profiling.

Journal Article Stat Med · December 15, 1997 Risk-adjustment and provider profiling have become common terms as the medical profession attempts to measure quality and assess value in health care. One of the areas of care most thoroughly developed in this regard is quality assessment for coronary arte ... Full text Link to item Cite

Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury.

Journal Article Osteoarthritis Cartilage · November 1997 OBJECTIVE: To examine the correlation between synovial fluid cartilage markers and degree of cartilage damage determined by arthroscopic evaluation in subjects with acute knee injury. DESIGN: Chondral damage was quantified using a validated arthroscopic sc ... Full text Link to item Cite

Relationship between diabetes mellitus and long-term survival after coronary bypass and angioplasty.

Journal Article Circulation · October 21, 1997 BACKGROUND: Recent subgroup analyses of randomized trials have suggested that percutaneous intervention in diabetic patients with multivessel disease results in higher mortality than coronary artery bypass graft surgery (CABG). We studied the relationship ... Full text Link to item Cite

Coronary stent costs completely recouped in six months

Journal Article CIRCULATION · October 21, 1997 Link to item Cite

Transportability of CABG mortality models

Journal Article CIRCULATION · October 21, 1997 Link to item Cite

Impact of early discharge after coronary artery bypass graft surgery on rates of hospital readmission and death. The Ischemic Heart Disease (IHD) Patient Outcomes Research Team (PORT) Investigators.

Journal Article J Am Coll Cardiol · October 1997 OBJECTIVES: This study examined the impact of early hospital discharge on short-term clinical outcomes of elderly patients treated with coronary artery bypass graft surgery (CABG) in the United States in 1992. BACKGROUND: Protocols that encourage earlier d ... Full text Link to item Cite

Racial variation in the use of coronary-revascularization procedures - Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · July 10, 1997 Link to item Cite

Relationship between physician and hospital coronary angioplasty volume and outcome in elderly patients.

Journal Article Circulation · June 3, 1997 BACKGROUND: With the expectation that physicians who perform larger numbers of coronary angioplasty procedures will have better outcomes, the American College of Cardiology/ American Heart Association guidelines recommend minimum physician volumes of 75 pr ... Full text Link to item Cite

Geographic variation in resource use for coronary artery bypass surgery. IHD Port Investigators.

Journal Article Med Care · April 1997 OBJECTIVES: The purpose of this study was to examine the national variability in patient-level cost and length of stay for coronary artery bypass grafting (CABG) in Medicare patients. METHODS: Retrospective multivariate regression analysis was done using M ... Full text Link to item Cite

Racial variation in the use of coronary-revascularization procedures. Are the differences real? Do they matter?

Journal Article N Engl J Med · February 13, 1997 BACKGROUND: Studies have reported that blacks undergo fewer coronary-revascularization procedures than whites, but it is not clear whether the clinical characteristics of the patients account for these differences or whether they indicate underuse of the p ... Full text Link to item Cite

Regional variation in post-MI testing: Results in 190,237 pts

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 1997 Link to item Cite

Outcome of acute myocardial infarction by physician specialty

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 1997 Link to item Cite

Post-MI testing in the elderly: Results in 190,135 patients

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 1997 Link to item Cite

Outcome of acute myocardial infarction according to the specialty of the admitting physician.

Journal Article N Engl J Med · December 19, 1996 BACKGROUND: In order to limit costs, health care organizations in the United States are shifting medical care from specialists to primary care physicians. Although primary care physicians provide less resource-intensive care, there is little information co ... Full text Link to item Cite

Identification of preoperative variables needed for risk adjustment of short-term mortality after coronary artery bypass graft surgery. The Working Group Panel on the Cooperative CABG Database Project.

Journal Article J Am Coll Cardiol · November 15, 1996 OBJECTIVES: The purpose of this consensus effort was to define and prioritize the importance of a set of clinical variables useful for monitoring and improving the short-term mortality of patients undergoing coronary artery bypass graft surgery (CABG). BAC ... Full text Link to item Cite

Can you believe your risk-adjusted outcomes

Journal Article CIRCULATION · October 15, 1996 Link to item Cite

Impact of an interactive video on decision making of patients with ischemic heart disease.

Journal Article J Gen Intern Med · June 1996 An experimental pilot study using repeated measures to examine the impact of an interactive video program on the decision making of patients with ischemic heart disease was carried on at a tertiary care center and a Veterans Affairs hospital. The patients ... Full text Link to item Cite

Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis.

Journal Article Am J Gastroenterol · April 1996 OBJECTIVES: Accurate preoperative prediction of choledocholithiasis is essential in order to minimize patient risk and curtail health care expenditures. This study was designed to identify independent risk factors for choledocholithiasis in patients who ha ... Link to item Cite

The ischemic heart disease port as related to guideline development

Conference AMERICAN STATISTICAL ASSOCIATION - 1996 PROCEEDINGS OF THE SECTION ON BAYESIAN STATISTICAL SCIENCE · January 1, 1996 Link to item Cite

Outcomes of coronary artery bypass graft surgery in 24,461 patients aged 80 years or older.

Journal Article Circulation · November 1, 1995 BACKGROUND: Coronary artery bypass graft surgery is increasingly common in patients of age > or = 80 years. Single-institution reviews have cited a wide range of mortality results after bypass surgery in this age group, in part because of limited sample si ... Full text Link to item Cite

VOLUME OF CORONARY ANGIOPLASTY PROCEDURES AND MORTALITY-RATES - REPLY

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · May 11, 1995 Link to item Cite

Measuring hospital mortality rates: are 30-day data enough? Ischemic Heart Disease Patient Outcomes Research Team.

Journal Article Health Serv Res · February 1995 OBJECTIVE: We compare 30-day and 180-day postadmission hospital mortality rates for all Medicare patients and those in three categories of cardiac care: coronary artery bypass graft surgery, acute myocardial infarction, and congestive heart failure. DATA S ... Link to item Cite

Measuring hospital mortality rates: Are 30-day data enough?

Journal Article Health Services Research · January 1, 1995 Objective. We compare 30-day and 180-day postadmission hospital mortality rates for all Medicare patients and those in three categories of cardiac care: coronary artery bypass graft surgery, acute myocardial infarction, and congestive heart failure. Data S ... Cite

The relation between the volume of coronary angioplasty procedures at hospitals treating Medicare beneficiaries and short-term mortality.

Journal Article N Engl J Med · December 15, 1994 BACKGROUND: Previous studies have found that hospitals at which more procedures, such as coronary-artery bypass grafting (CABG) and other vascular surgery, are performed have lower rates of mortality related to these procedures than hospitals where fewer s ... Full text Link to item Cite

Changes in mortality after myocardial revascularization in the elderly. The national Medicare experience.

Journal Article Ann Intern Med · December 15, 1994 OBJECTIVE: To examine secular changes in the use and outcome of percutaneous transluminal coronary angioplasty and cardiac bypass graft surgery in the elderly. DESIGN: A retrospective cohort study based on a longitudinal database created from the administr ... Full text Link to item Cite

OUTCOMES OF CORONARY-BYPASS SURGERY IN US OCTOGENARIANS

Journal Article CIRCULATION · October 1, 1994 Link to item Cite

Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty.

Journal Article Circulation · May 1994 BACKGROUND: Survival after coronary artery bypass graft surgery (CABG) and medical therapy in patients with coronary artery disease (CAD) has been studied in both randomized trials and observational treatment comparisons. Over the past decade, the use of c ... Full text Link to item Cite

Absence of sex bias in the referral of patients for cardiac catheterization.

Journal Article N Engl J Med · April 21, 1994 BACKGROUND: It has been suggested that women with clinical evidence of coronary artery disease are less often referred for cardiac catheterization than are men. To determine whether there is sex-related bias in referral for cardiac catheterization, we pros ... Full text Link to item Cite

Programmed Outcome Research Teams (PORTs) and implications for clinical practice.

Journal Article Am J Cardiol · March 10, 1994 The spiraling cost of health care has created a health care crisis. Concerns about the appropriate use of expensive medical technologies have been heightened by health services research studies that demonstrate widespread and dramatic geographic variabilit ... Full text Link to item Cite

DO WOMEN WITH CORONARY-DISEASE TRULY GET TREATED DIFFERENTLY THAN MEN

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 1994 Link to item Cite

THE NATIONAL MEDICARE EXPERIENCE - CHANGING PATTERNS OF MYOCARDIAL REVASCULARIZATION UTILIZATION AND OUTCOME

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 1994 Link to item Cite

Discordance of databases designed for claims payment versus clinical information systems. Implications for outcomes research.

Journal Article Ann Intern Med · October 15, 1993 OBJECTIVE: To determine the suitability of insurance claims information for use in clinical outcomes research in ischemic heart disease. DESIGN: Concordance study of two databases. SETTING: Tertiary care referral center. PATIENTS: A total of 12,937 consecu ... Full text Link to item Cite

ISCHEMIC HEART DISEASE PROGRAM OUTCOME RESEARCH TEAM (PORT)

Conference CANADIAN JOURNAL OF CARDIOLOGY, VOL 9, SUPPLEMENT D, MAY 1993 · January 1, 1993 Link to item Cite

Impact of glucose self-monitoring on non-insulin-treated patients with type II diabetes mellitus. Randomized controlled trial comparing blood and urine testing.

Journal Article Diabetes Care · October 1990 The goal of this study was to compare the relative efficacy and cost of self-monitoring of blood glucose (SMBG) with routine urine testing in the management of patients with type II (non-insulin-dependent) diabetes mellitus not treated with insulin. Fifty- ... Full text Link to item Cite

Transdermal viprostol in the treatment of male pattern baldness.

Journal Article J Am Acad Dermatol · September 1990 Fifty-seven men were randomly assigned for treatment of androgenetic alopecia with viprostol, vehicle, or placebo twice daily for 24 weeks. Nonvellus hair growth was assessed subjectively by both patient and investigator and objectively through hair counts ... Full text Link to item Cite

Randomized, double-blind, placebo-controlled, patient-initiated study of topical high- and low-dose interferon-alpha with nonoxynol-9 in the treatment of recurrent genital herpes.

Journal Article J Infect Dis · April 1990 To explore further topical antiviral therapy for recurrent genital herpes, 188 culture-proven patients were randomized to receive treatment with topical interferon-alpha in high-dose (10(6) IU/g with 1% nonoxynol-9 in 3.5% methylcellulose) or low-dose (10( ... Full text Link to item Cite

Five-year follow-up of men with androgenetic alopecia treated with topical minoxidil.

Journal Article J Am Acad Dermatol · April 1990 Thirty-one men with androgenetic alopecia completed 4 1/2 to 5 years of therapy with 2% and 3% topical minoxidil. Hair regrowth with topical minoxidil tended to peak at 1 year with a slow decline in regrowth over subsequent years. However, at 4 1/2 to 5 ye ... Full text Link to item Cite

A controlled trial of two low-dose heparin regimens for the prevention of postoperative deep vein thrombosis.

Journal Article Obstet Gynecol · April 1990 Venous thromboembolism is a serious complication following gynecologic surgery and is particularly common in patients with malignancy. A previous study of subcutaneous low-dose heparin given as one dose preoperatively and every 12 hours postoperatively fai ... Link to item Cite

Natural history of androgenetic alopecia.

Journal Article Clin Exp Dermatol · January 1990 Twenty-two men with patterns III-Va androgenetic alopecia were entered into a 10-month study aimed at establishing information on the natural progression of hair loss over a period of time typical of studies of hair growth promoters. The methodology employ ... Full text Link to item Cite

Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma.

Journal Article J Clin Oncol · July 1989 We conducted a phase II study of intravenous (IV) melphalan in the treatment of children with recurrent medulloblastoma and in the initial treatment of children with poor-prognosis medulloblastoma and pineoblastoma. There was one complete response (CR) and ... Full text Link to item Cite

Effect of daily charge feedback on inpatient charges and physician knowledge and behavior.

Journal Article Arch Intern Med · February 1989 Concurrent charge feedback has gained widespread acceptance as a method of minimizing hospitals' losses under the Medicare prospective payment system despite the fact that its effect on patient outcomes, physician behavior, or charges has not been studied ... Link to item Cite

Impact of a medical journal club on house-staff reading habits, knowledge, and critical appraisal skills. A randomized control trial.

Journal Article JAMA · November 4, 1988 The journal club is an established teaching modality in many house-staff training programs. To determine if a journal club improves house-staff reading habits, knowledge of epidemiology and biostatistics, and critical appraisal skills, we randomized 44 med ... Link to item Cite

Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.

Journal Article Biometrics · September 1988 Methods of evaluating and comparing the performance of diagnostic tests are of increasing importance as new tests are developed and marketed. When a test is based on an observed variable that lies on a continuous or graded scale, an assessment of the overa ... Link to item Cite

Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit.

Journal Article Crit Care Med · July 1988 Patients with hepatic failure admitted to the medical ICU (MICU) generally have a poor prognosis. To determine if there were readily identifiable clinical factors associated with a high predictive value for outcome, we reviewed retrospectively the charts o ... Full text Link to item Cite

Erythrocyte anisocytosis. Visual inspection of blood films vs automated analysis of red blood cell distribution width.

Journal Article Arch Intern Med · April 1988 An improved anemia classification may be available by combining measures of red blood cell size variability with mean corpuscular volume. Visual inspection of the peripheral blood film allows semiquantitative description of anisocytosis while quantitative ... Full text Link to item Cite

Intestinal obstruction in patients with ovarian cancer. Variables associated with surgical complications and survival.

Journal Article Arch Surg · January 1988 Intestinal obstruction is frequently encountered in patients with ovarian cancer. Surgical correction of intestinal obstruction may allow the prolonged survival of some patients. We identified prognostic factors associated with operative complications and ... Full text Link to item Cite

Inter-examiner reproducibility of probing pocket depths in molar furcation sites.

Journal Article J Clin Periodontol · January 1988 This investigation was designed to determine the reproducibility of probing pocket depths in maxillary facial and mandibular facial and lingual grade II and III molar furcation sites. 80 untreated molar teeth with 102 furcation invasions due to periodontit ... Full text Link to item Cite

Effect of ultraviolet light on topical minoxidil-induced hair growth in advanced male pattern baldness.

Journal Article J Am Acad Dermatol · May 1987 Nine healthy men with type IVa or Va male pattern baldness completed a 4-month single-blinded controlled pilot study designed to assess the effect of ultraviolet light (UVL) on topical minoxidil-induced hair growth. Subjects applied 2% topical minoxidil so ... Full text Link to item Cite

Double-blind, placebo-controlled trial of potassium chloride in the treatment of mild hypertension.

Journal Article Hypertension · May 1987 Epidemiological and experimental data suggest blood pressure-lowering effects of dietary potassium. A randomized, double-blind clinical trial was used to assess blood pressure response to orally administered potassium, 120 mEq/day, and to placebo in 101 ad ... Full text Link to item Cite

Phase II diaziquone-based chemotherapy trials in patients with anaplastic supratentorial astrocytic neoplasms.

Journal Article J Clin Oncol · March 1987 We treated 103 patients with histologically confirmed anaplastic supratentorial astrocytic neoplasms with either diaziquone (AZQ) and carmustine (BCNU) or AZQ and procarbazine. There were 74 patients with glioblastoma multiforme (GBM) and 29 patients with ... Full text Link to item Cite

Long-term follow-up of men with male pattern baldness treated with topical minoxidil.

Journal Article J Am Acad Dermatol · March 1987 Forty-one men with male pattern baldness completed 132 study weeks (2 years 9 months) with topical minoxidil and had follow-up 1-inch target-area vertex scalp hair counts. Initially these men were treated with either twice-daily 2% topical minoxidil for 12 ... Full text Link to item Cite

A quantitative analysis of palliative care decisions in acute nonlymphocytic leukemia.

Journal Article J Am Geriatr Soc · February 1987 With the increasing incidence of cancer in elderly patients, decisions to adopt palliative care become particularly relevant to this patient population. In order to define characteristics of decisions to adopt palliative care, including those factors influ ... Full text Link to item Cite

Variables associated with postoperative deep venous thrombosis: a prospective study of 411 gynecology patients and creation of a prognostic model.

Journal Article Obstet Gynecol · February 1987 Deep venous thrombosis is a major complication following gynecologic surgery. Assessing a patient's risk of developing deep venous thrombosis is important for patient selection and in choosing appropriate prophylactic methods. Four hundred eleven patients ... Link to item Cite

Reply

Journal Article Journal of the American Academy of Dermatology · January 1, 1987 Full text Cite

Intermediate, indeterminate, and uninterpretable diagnostic test results.

Journal Article Med Decis Making · 1987 Diagnostic tests do not always yield positive or negative results; sometimes the results are intermediate, indeterminate, or uninterpretable. No consensus exists for the incorporation of such results into data assessment. Conventional Bayesian analysis lea ... Full text Link to item Cite

Surgical management of intestinal obstruction in ovarian cancer. I. Clinical features, postoperative complications, and survival.

Journal Article Gynecol Oncol · January 1987 The results of surgery to relieve intestinal obstruction in 49 patients who were known to have ovarian cancer were studied. All patients had received adjunctive chemotherapy and/or radiation therapy prior to bowel obstruction. Thirty patients had small bow ... Full text Link to item Cite

A comparison of methods for the estimation of plasma low- and very low-density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study.

Journal Article JAMA · November 7, 1986 Using data from over 10 000 men, women, and children who participated in the Lipid Research Clinics prevalence studies, we have examined the formula adopted by Friedewald et al for estimating plasma or serum concentrations of low-density lipoprotein choles ... Link to item Cite

RESIDENT TURNOVER - REPLY

Journal Article JOURNAL OF GENERAL INTERNAL MEDICINE · September 1, 1986 Link to item Cite

Dose-response study of topical minoxidil in male pattern baldness.

Journal Article J Am Acad Dermatol · July 1986 Eighty-nine healthy men with male pattern baldness completed a 6-month double-blind, placebo-controlled study of 0.01%, 0.1%, 1%, and 2% topical minoxidil. Subjects on 2% topical minoxidil had a statistically significant increase in mean total target area ... Full text Link to item Cite

ACCURACY AND RELIABILITY OF AUSCULTATION OF THE S3 GALLOP

Journal Article CLINICAL RESEARCH · April 1, 1986 Link to item Cite

The resident leaves the clinic: the effects of changing physicians on appointment-keeping behavior.

Journal Article J Gen Intern Med · 1986 To understand the effect that termination of an established physician-patient relationship has on patient attendance patterns in a medical clinic, appointment scheduling and patient attendance were measured for 210 patients before and after 11 senior resid ... Full text Link to item Cite

Observer variability in the pulmonary examination.

Journal Article J Gen Intern Med · 1986 Observer variability in the pulmonary examination was assessed by having four blindfolded observers (two medical students and two pulmonary physicians) twice examine 31 patients with abnormal pulmonary findings. Examiners were consistent in the repetitive ... Full text Link to item Cite

Effects of bombesin on fasting bile formation.

Journal Article Ann Surg · January 1986 Adult dogs were previously prepared by cholecystectomy, ligation of the lesser pancreatic duct, and insertion of cannulae into the duodenum and stomach. After a 2-week period of postoperative recovery and an overnight fast, bile ducts were cannulated, gast ... Full text Link to item Cite

Resident turnover.

Journal Article J Gen Intern Med · 1986 Full text Link to item Cite

ACCURACY AND RELIABILITY OF AUSCULTATION OF THE S3 GALLOP

Journal Article CLINICAL RESEARCH · January 1, 1986 Link to item Cite

Reply

Journal Article Journal of the American Academy of Dermatology · January 1, 1986 Full text Cite

Sensitivity and specificity of a monitoring test.

Journal Article Biometrics · December 1985 The usefulness of a diagnostic test is generally assessed by calculating the sensitivity and specificity, or the predictive value positive and predictive value negative of the test. When subjects are monitored periodically for evidence of disease, these ca ... Link to item Cite

Multiple myeloma and family history of cancer. A case-control study.

Journal Article Cancer · October 15, 1985 A hospital-based case-control study was done to examine the hypothesis that persons with a family history of multiple myeloma (MM) or other cancers are at increased risk of multiple myeloma. Study members were 439 cases of multiple myeloma and 1317 matched ... Full text Link to item Cite

Topical minoxidil in early male pattern baldness.

Journal Article J Am Acad Dermatol · August 1985 One-hundred twenty-six healthy men with early male pattern baldness completed a 12-month double-blind, controlled trial of 2% and 3% topical minoxidil. Subjects were initially randomly assigned to use placebo or 2% or 3% topical minoxidil. After 4 months o ... Full text Link to item Cite

Socioeconomic status and risk of multiple myeloma.

Journal Article J Epidemiol Community Health · June 1985 A case control study was conducted to test the hypothesis that socioeconomic status is positively associated with multiple myeloma incidence. One hundred and fifty-three myeloma cases and 459 controls were identified at the Duke University Medical Center a ... Full text Link to item Cite

Tumor-associated antigen TAG-72: correlation of expression in primary and metastatic breast carcinoma lesions.

Journal Article Breast Cancer Res Treat · 1985 Variability of tumor-associated antigens among and within human tumor cell groups presents a potential problem in the development and optimization of immunodiagnostic and therapeutic procedures for cancer. We determined the degree of expression of a tumor- ... Full text Link to item Cite

Renal transplant monitoring with serum β-2-microglobulin and creatinine

Journal Article Transplantation Proceedings · January 1, 1985 Cite

RENAL-TRANSPLANT MONITORING WITH SERUM BETA-2-MICROGLOBULIN AND CREATININE

Journal Article TRANSPLANTATION PROCEEDINGS · January 1, 1985 Link to item Cite

Complications of low-dose heparin prophylaxis in gynecologic oncology surgery.

Journal Article Obstet Gynecol · November 1984 The clinical and laboratory effects of low-dose heparin prophylaxis was prospectively studied in a controlled trial of 182 patients undergoing major surgery for gynecologic malignancy. Low-dose heparin was given in 5000 U subcutaneously two hours preoperat ... Link to item Cite

An approach to conducting epidemiologic research within cooperative clinical trials groups.

Journal Article J Clin Oncol · June 1984 Cooperative clinical trials groups offer exciting opportunities for conducting epidemiologic research for several reasons: they facilitate accrual of sufficient numbers of subjects in a short period of time, even for studies of rare diseases; they provide ... Full text Link to item Cite

Articulation development in children with cleft lip/palate.

Journal Article Cleft Palate J · April 1984 This longitudinal study analyzed the articulation development of 108 children with cleft lip/palate from three through eight years of age. The data suggest that as the severity of clefting increases the severity of the articulation deficit does also. Age a ... Link to item Cite

Climate, socioeconomic status and Hodgkin's disease mortality in the United States.

Journal Article J Chronic Dis · 1984 This study examines the relative effects of climate and socioeconomic status (SES) on standard mortality ratios (SMR) from both young adult and older adult Hodgkin's disease (HD) in the United States. Climate variables explain a greater percentage of the v ... Full text Link to item Cite

SPONTANEOUS LYMPHATIC METASTASIS BY HUMAN-PROSTATE CARCINOMA-CELLS IN TUMOR-BEARING ATHYMIC NUDE-MICE

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1984 Link to item Cite

Secular trends in ischemic heart disease mortality: regional variation.

Journal Article Circulation · July 1983 We compared secular trends in ischemic heart disease (IHD) mortality in four southeastern states (North Carolina, Georgia, South Carolina, and Virginia) with those in three selected other states (California, New York, and Utah). Mortality data were obtaine ... Full text Link to item Cite

The Extended Two-Sample Problem: Progressively Truncated Estimation Of P{X > Y}

Journal Article Statistics and Risk Modeling · January 1, 1983 The “two-samgle extended problem”, in which infer- ence concerning two distributions, F and G, is based on samples from distributions F* = Q1(F) and G* = Q2(G) (for known Q1, Q2 but unknown F and G), is viewed with respect to the estimation of P{X > Y} = ∫ ... Full text Cite

OBSERVER VARIABILITY AND RELIABILITY IN THE PULMONARY EXAM

Journal Article CLINICAL RESEARCH · January 1, 1983 Link to item Cite

AN APPROACH TO CONDUCTING EPIDEMIOLOGIC RESEARCH IN COOPERATIVE CLINICAL-TRIALS GROUPS

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · January 1, 1983 Link to item Cite

Environmental factors in the etiology of rhabdomyosarcoma in childhood.

Journal Article J Natl Cancer Inst · January 1982 In a case-control study of childhood rhabdomyosarcoma (RMS), families of 33 cases and 99 controls were interviewed. A relative risk (RR) of 3.9 was found associated with fathers' (but not mothers') cigarette smoking (P = 0.003). Cases had had fewer immuniz ... Link to item Cite

ANALYSES OF SECULAR TRENDS IN ISCHEMIC-HEART-DISEASE MORTALITY IN NORTH-CAROLINA

Journal Article AMERICAN JOURNAL OF EPIDEMIOLOGY · January 1, 1981 Link to item Cite

Estimation of p{x >y} based on progressively truncated versions of the wilcoxon-mann-whitney statistics

Journal Article Communications in Statistics - Theory and Methods · January 1, 1981 Stochastic processes related to some generalized U-statistics (with especial emphasis on the Wilcoxon-Mann-Whitney (WMW-) statistic), under progressive right censoring, are considered for prediction purposes. Their weak convergence results are incorporated ... Full text Cite

ENVIRONMENTAL-FACTORS IN THE ETIOLOGY OF CHILDHOOD RHABDOMYOSARCOMA

Journal Article AMERICAN JOURNAL OF EPIDEMIOLOGY · January 1, 1980 Link to item Cite