Journal ArticleN C Med J · 2003
Type 2 diabetes is a spectacularly large and growing health problem. Patients with diabetes have healthcare expenditures that are twice those of the average citizen. We do not clearly understand the genetic predisposition that allows type 2 diabetes to dev ...
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Journal ArticleN C Med J · 2003
Type 2 diabetes is a spectacularly large and growing health problem. Patients with diabetes have healthcare expenditures that are twice those of the average citizen. We do not clearly understand the genetic predisposition that allows type 2 diabetes to dev ...
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Journal ArticleJ Behav Med · October 1993
Cluster analysis of the MMPI has been utilized widely in the chronic low back pain literature to try to identify reliable patient subtypes predictive of treatment outcome. We extended this methodology to patients with heterogeneous chronic medical conditio ...
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Journal ArticleMed Care · September 1990
In this study the relationship between four psychologic health constructs (depression, anxiety, patient response bias, and hostility) and the Sickness Impact Profile (SIP) measurement of functional status was evaluated. The SIP, Carroll Depression Rating S ...
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Journal ArticleSurgery · December 1989
We obtained serial serum and urine samples from 14 patients with primary hyperparathyroidism both before and 3 to 9 months after excision of their parathyroid adenomas to (1) determine whether the circadian rhythms for calcium, phosphorus, and parathyroid ...
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Journal ArticleJ Gen Intern Med · 1986
Observer variability in the pulmonary examination was assessed by having four blindfolded observers (two medical students and two pulmonary physicians) twice examine 31 patients with abnormal pulmonary findings. Examiners were consistent in the repetitive ...
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Journal ArticleArch Intern Med · July 1984
We used standard, large adult, and thigh-size cuffs in random order to take BPs in 470 patients. The prevalences of definite high BP [( HBP]), greater than or equal to 160/95 mm Hg) and borderline HBP [( BHBP ], greater than or equal to 140/90 less than 16 ...
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Journal ArticleArch Intern Med · May 1983
Many hypertensive patients, especially those in outpatient clinics at large teaching hospitals, do not achieve BP control. We incorporated a physician's associate into an existing house staff medical clinic and evaluated whether this improved BP control. I ...
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Journal ArticleJ R Coll Gen Pract · July 1981
During assessment of 55 outpatients, we recorded the numbers and kind of health problems noted during an open-ended interview and during an ;interrogation' based on a structured questionnaire. The combined strategies (interviews and questionnaires) identif ...
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Journal ArticleN Engl J Med · November 6, 1980
We evaluated water metabolism in 11 patients with hypothalamic-pituitary sarcoidosis. Seven patients had abnormal water metabolism: one had partial antidiuretic hormone (ADH) deficiency, one had severe ADH deficiency, one had severe ADH deficiency and defi ...
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Journal ArticleAnn Intern Med · May 1978
Ten patients with generalized sarcoidosis and hypopituitarism were studied. Six of these 10 patients presented with sarcoid involvement of the optic nerves resulting in asymmetric visual field defects. All patients had deficiencies of two or more anterior ...
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Journal ArticleJ Clin Invest · October 1977
Standard clearance studies were performed in mechanically ventilated intact and acutely thyroparathyroidectomized (TPTX) rats to document and characterize the effect of hypercapnia (HC) on urinary phosphorus excretion (U(P)V). HC as compared to normocapnia ...
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Journal ArticleJ Clin Endocrinol Metab · July 1977
A 17 year old man with longstanding hypocalcemia and hyperphosphatemia presented with incapacitating bone pain and progressive weakness nad bowing of the legs. The serum abnormalities were due to idiopathic hypoparathyroidism as evidenced by a decreased se ...
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Journal ArticleSouth Med J · June 1977
Two family members developed severe hepatitic dysfunction in association with infectious mononucleosis and acetaminophen administration. Since severe hepatitis is an extremely rare complication of infectious mononucleosis, we postulate that the hepatic dys ...
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Journal ArticleMetabolism · October 1976
Measurement of total urine cyclic 3':5'-adenosine monophosphate (cyclic AMP) only incompletely discriminates between normal, hyperparathyroid, and nonparathyroid hypercalcemic patients. Only a fraction of total urine cyclic AMP is contributed by parathyroi ...
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Journal ArticleArch Intern Med · September 1976
A 43-year-old woman had diabetes insipidus and amenorrhea. There was panhypopituitarism on endocrine testing and visual field examination showed inexorably progressive loss to bitemporal hemianopsia. All radiographic findings were normal, but craniotomy di ...
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Journal ArticleBiochim Biophys Acta · April 2, 1976
The role of cyclic AMP in the regulation of cartilage macromolecule synthesis in vitro was studied in pelvic cartilage from 10-12 day chick embryos. Incubation of cartilages in medium containing 0.5 mM cyclic AMP resulted in a 30% inhibition of 35SO4-2, [3 ...
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Journal ArticleJ Clin Endocrinol Metab · April 1976
Pseudohypoparathyroidism (PsH) is a genetic disease characterized by hypocalcemia, hyperphosphatemia, and metabolic unresponsiveness to parathyroid hormone (PTH). The administration of PTH elicits neither a significant rise in serum calcium (calcemic respo ...
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Book · January 1, 1976
Evidence is presented to show that cyclic AMP stimulates cartilage growth processes and that some or all of the actions of growth hormone dependent serum sulfation factor may be mediated by the generation of cyclic AMP. We have further presented a theoreti ...
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Journal ArticleBiochim Biophys Acta · November 18, 1975
Insulin has been isolated from pancreases of the Syrian hamster and from a transplantable islet-cell tumor of the hamster. Acid/ethanol extraction, ether precipitation, ion exchange and gel filtration chromatography gave preparations of suitable purity for ...
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Journal ArticleBiochim Biophys Acta · February 13, 1975
The effects of growth hormone-dependent serum factors on amino acid transport and on cartilage cyclic AMP levels in embryonic chicken cartilage were studied in vitro. Cartilages incubated in medium containing rat serum showed a significantly greater uptake ...
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Journal ArticleJournal of Biological Chemistry · January 1, 1973
The authors chromatographically purified butyrylated analogues of cyclic adenosine 3':5' monophosphate (cAMP) to displace [3H]cAMP bound to a partially purified bovine muscle protein kinase preparation. O2' Monobutyryl cAMP (O2MBC) showed a linear displace ...
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Journal ArticleFederation Proceedings · January 1, 1973
Insulin, isolated from hamster pancreata by acid ethanol extraction, membrane ultrafiltration, DEAE cellulose and Sephadex G50 chromatography, was pure and used for sequence studies. Amino acid sequence was established by tryptic cleavage and both manual a ...
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Journal ArticleScience · July 15, 1966
The separation of mixed oligoribonucleotides obtained from enzymatic digestion of soluble RNA into fractions containing mixed oligonucleotides of identical chain length is improved by absence of terminal phosphate. Each fraction may be separated into indiv ...
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