Scholars@Duke
Emily Reinke

Emily Reinke

Research Program Leader, Sr
Orthopaedic Surgery
emily.reinke@duke.edu
3475 Erwin Road, Wallace Building, Durham, NC 27705

Selected Publications

Outcomes Following Repair of Radial, Mid-Body Tears of the Lateral Meniscus in Adolescents

Journal Article Journal of the Pediatric Orthopaedic Society of North America · November 2023 Full text Cite

Early Initiation of Vestibular Therapy Following Sports-Related Concussions: A Retrospective Cohort Study.

Journal Article Cureus · May 2023 BackgroundVestibular dysfunction is common following sports-related concussions (SRC). Within the current practice, it is theorized that patients with vestibular dysfunction as sequelae of sports-related concussion have a prolonged recovery time c ... Full text Cite

Can Patient-Reported Outcome Measurement Information System Measures Differentiate Patients Who Will Undergo Hip and Knee Total Joint Arthroplasty: A Retrospective Case-Control Study.

Journal Article J Arthroplasty · June 2022 BACKGROUND: The Patient-Reported Outcome Measurement Information System (PROMIS) can be used to monitor patients in population-health-based programs. However, it is unknown which measures are most appropriate to differentiate patients who will undergo hip ... Full text Link to item Cite

Venous Thromboembolism Prophylaxis and Hormonal Contraceptive Management Practice Patterns in the Perioperative Period for Anterior Cruciate Ligament Reconstruction.

Journal Article Arthrosc Sports Med Rehabil · April 2022 PURPOSE: To evaluate the venous thromboembolism (VTE) prophylaxis practices of surgeons performing anterior cruciate ligament reconstruction (ACLR) in female patients using hormonal contraceptives. METHODS: Our research team designed an investigational sur ... Full text Open Access Link to item Cite

Meniscal Treatment as a Predictor of Worse Articular Cartilage Damage on MRI at 2 Years After ACL Reconstruction: The MOON Nested Cohort.

Journal Article The American journal of sports medicine · March 2022 BackgroundPatients undergoing anterior cruciate ligament reconstruction (ACLR) are at an increased risk for posttraumatic osteoarthritis (PTOA). While we have previously shown that meniscal treatment with ACLR predicts more radiographic PTOA at 2 ... Full text Cite

Medical Diagnoses in a University Athlete Training Room Clinic.

Journal Article Clin J Sport Med · January 1, 2022 INTRODUCTION: Approximately 560 000 student-athletes participate in university athletic programs every year. These athletes develop a variety of medical injuries and illnesses during their time at the university. There is currently a paucity of data with r ... Full text Link to item Cite

Protocol for a multicenter, randomised controlled trial of surgeon-directed home therapy vs. outpatient rehabilitation by physical therapists for reverse total shoulder arthroplasty: the SHORT trial.

Journal Article Arch Physiother · December 10, 2021 BACKGROUND: Reverse total shoulder arthroplasty (RTSA) has emerged as a successful surgery with expanding indications. Outcomes may be influenced by post-operative rehabilitation; however, there is a dearth of research regarding optimal rehabilitation stra ... Full text Link to item Cite

Hybrid Transtibial Femoral Preparation for Transphyseal Anterior Cruciate Ligament Reconstruction: A Radiographic Comparison With the Transtibial and Anteromedial Portal Techniques.

Journal Article Orthopaedic journal of sports medicine · November 2021 BackgroundTransphyseal anterior cruciate ligament (ACL) reconstruction remains the most commonly used technique for pubescent patients. The transtibial (TT) drilling technique creates vertical and central femoral tunnels to minimize the physeal ar ... Full text Cite

The Incidence of Post-Traumatic Osteoarthritis on Clinical Radiographs at 10 Years after Anterior Cruciate Ligament Reconstruction: Data from the MOON Nested Cohort (168)

Journal Article Orthopaedic journal of sports medicine · October 2021 Objectives: 1) To prospectively determine the incidence of post-traumatic osteoarthritis (PTOA) at 10 years after anterior cruciate ligament reconstruction (ACLR) in young athletic patients on clinical radiographs: and 2) to determine the average ... Cite

Use of Patient-Reported Outcomes Measurement Information System (PROMIS) measures to characterise health status for patients seeking care from an orthopaedic provider: a retrospective cohort study.

Journal Article BMJ Open · September 2, 2021 OBJECTIVES: Characterise the health status of patients newly consulting an orthopaedic specialist across eight clinical subspecialties. DESIGN: Retrospective cohort. SETTING: 18 orthopaedic clinics, including 8 subspecialties (14 ambulatory and 4 hospital ... Full text Open Access Link to item Cite

Neither Residual Anterior Knee Laxity Up to 6 mm nor a Pivot Glide Predict Patient-Reported Outcome Scores or Subsequent Knee Surgery Between 2 and 6 Years After ACL Reconstruction.

Journal Article The American journal of sports medicine · August 2021 BackgroundA primary goal of anterior cruciate ligament reconstruction (ACLR) is to reduce pathologically increased anterior and rotational laxity of the knee, but the effects of residual laxity on patient-reported outcomes (PROs) after ACLR remain ... Full text Cite

Establishing Age- and Sex-Specific Norms for Pediatric Return-to-Sports Physical Performance Testing.

Journal Article Orthop J Sports Med · August 2021 BACKGROUND: Graft tears and contralateral anterior cruciate ligament (ACL) tears are common in pediatric athletes after ACL reconstruction. Use of objective return-to-sports (RTS) criteria, in particular physical performance tests (PPTs), is believed to re ... Full text Link to item Cite

Composite psychosocial risk based on the fear avoidance model in patients undergoing anterior cruciate ligament reconstruction: Cluster-based analysis.

Journal Article Phys Ther Sport · July 2021 OBJECTIVES: To examine associations between preoperative fear-avoidance model (FAM) risk subgroup status and patient expectation of surgical success with postoperative outcomes at 6 and 12 months after anterior cruciate ligament reconstruction (ACLR). DESI ... Full text Link to item Cite

Can PROMIS measures be used to create subgroups for patients seeking orthopaedic care?

Journal Article Bone Jt Open · July 2021 AIMS: Patient-reported outcome measures have become an important part of routine care. The aim of this study was to determine if Patient-Reported Outcomes Measurement Information System (PROMIS) measures can be used to create patient subgroups for individu ... Full text Open Access Link to item Cite

ESTIMATED PERFORMANCE FOR AGE: A NOVEL CRITERION FOR RETURN TO SPORT AFTER ANTERIOR CRUCIATE RECONSTRUCTION AND ITS PERFORMANCE COMPARED TO LIMB SYMMETRY INDICES

Journal Article Orthopaedic journal of sports medicine · July 2021 INTRODUCTION: The use of physical performance tests (PPT) for assessing readiness for return to sport (RTS) after ACL reconstruction in children is typically assessed based on a limb symmetry index (LSI). However, recent data show that: 1) healthy ... Cite

Electronic health record-integrated approach for collection of patient-reported outcome measures: a retrospective evaluation.

Journal Article BMC health services research · June 2021 BackgroundThe integration of Patient Reported Outcome Measures (PROMs) into clinical care presents many challenges for health systems. PROMs provide quantitative data regarding patient-reported health status. However, the most effective model for ... Full text Cite

Comparison of the accuracy of telehealth examination versus clinical examination in the detection of shoulder pathology.

Journal Article J Shoulder Elbow Surg · May 2021 HYPOTHESIS/BACKGROUND: In 2017, the American Orthopaedic Association advocated for the increased use of telehealth as an assessment and treatment platform, and demand has significantly increased during the coronavirus disease 2019 pandemic. Diagnostic effe ... Full text Link to item Cite

The Clinical Radiographic Incidence of Posttraumatic Osteoarthritis 10 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON Nested Cohort.

Journal Article The American journal of sports medicine · April 2021 BackgroundThe incidence of posttraumatic osteoarthritis (PTOA) based on clinical radiographic grading criteria at 10 years after anterior cruciate ligament (ACL) reconstruction (ACLR) has not been well-defined in a prospective cohort of young athl ... Full text Cite

Do Bone-Patellar Tendon-Bone ACL-Reconstructed Knees Have More Signs of Patellofemoral Posttraumatic Osteoarthritis Than Their Uninjured Contralateral Knees at 2 Years?

Journal Article Orthopaedic journal of sports medicine · January 2021 BackgroundThe prevalence of patellofemoral joint (PFJ) osteoarthritis ranges from 8% to 47% at 7 to 10 years after anterior cruciate ligament reconstruction (ACLR) using bone-patellar tendon-bone (BTB) autograft. In performing BTB ACLR, some hypot ... Full text Cite

Healthy Pediatric Athletes Have Significant Baseline Limb Asymmetries on Common Return-to-Sport Physical Performance Tests.

Journal Article Orthop J Sports Med · January 2021 BACKGROUND: Return to sport (RTS) after anterior cruciate ligament (ACL) reconstruction in children is associated with a much higher risk (∼30%) of subsequent ACL injury than in adults. Most RTS testing protocols use a limb symmetry index (LSI) ≥90% on phy ... Full text Link to item Cite

Development of Concise Physical Performance Test Batteries in Young Athletes.

Journal Article Med Sci Sports Exerc · December 2020 PURPOSE: This study aimed 1) to define the principal components of physical function assessed by 10 common lower extremity physical performance tests and 2) to derive a reduced-item set of physical performance tests that efficiently and accurately measures ... Full text Link to item Cite

Reporting and utilization of Patient-Reported Outcomes Measurement Information System® (PROMIS®) measures in orthopedic research and practice: a systematic review.

Journal Article J Orthop Surg Res · November 23, 2020 BACKGROUND: The Patient-Reported Outcomes Measurement Information SystemⓇ (PROMISⓇ) is a dynamic system of psychometrically sound patient-reported outcome (PRO) measures. There has been a recent increase in the use of PROMIS measures, yet little has been w ... Full text Open Access Link to item Cite

Incidence and Predictors of Subsequent Surgery After Anterior Cruciate Ligament Reconstruction: A 6-Year Follow-up Study.

Journal Article The American journal of sports medicine · August 2020 BackgroundThe cause of subsequent surgery after anterior cruciate ligament (ACL) reconstruction varies, but if risk factors for specific subsequent surgical procedures can be identified, we can better understand which patients are at greatest risk ... Full text Cite

Relationship Between Pain Catastrophizing and 6-Month Outcomes Following Anterior Cruciate Ligament Reconstruction.

Journal Article Journal of sport rehabilitation · August 2020 BackgroundPain catastrophizing predicts poor outcomes following orthopedic procedures for patients with chronic conditions; however, limited research has focused on acute injuries. This study aimed to quantify the progression of Pain Catastrophizi ... Full text Cite

Do BTB ACLR Knees have more MRI signs of PTOA than their Contralateral Normal Knee at 2 Years?

Journal Article Orthopaedic journal of sports medicine · July 2020 Objectives: The prevalence of patellofemoral joint (PFJ) osteoarthritis (OA) ranges from 8-47% 7-10 years after anterior cruciate ligament reconstructions (ACLR) using bone-patellar tendon-bone (BTB) autograft. In performing BTB ACLR, some hypothe ... Cite

GRAFT CHOICE FOR ACL RECONSTRUCTION IN YOUNG ACTIVE PATIENTS – USE OF QUADRICEPS TENDON AUTOGRAFT INCREASED LIKELIHOOD OF MEETING RETURN TO PLAY CRITERIA AT 6 MONTHS POST SURGERY

Journal Article Orthopaedic journal of sports medicine · April 2020 Background: ACL graft tears and contralateral injuries are problematic in pediatric sports medicine, with a combined incidence of 25-35%. Recent publications have highlighted a high failure rate with hamstring autografts in young patients, while o ... Cite

Anterior Cruciate Ligament Reconstruction in High School and College-Aged Athletes: Does Autograft Choice Influence Anterior Cruciate Ligament Revision Rates?

Journal Article Am J Sports Med · February 2020 BACKGROUND: Physicians' and patients' decision-making process between bone-patellar tendon-bone (BTB) and hamstring tendon autografts for anterior cruciate ligament (ACL) reconstruction (ACLR) may be influenced by a variety of factors in the young, active ... Full text Link to item Cite

Mid-Term Clinical Outcomes of Intraarticular Injection of Platelet Rich Plasma and Adipose-Derived MesenchymalStem Cells for the Treatment of Intra articular Pathology of the Knee, Hip and Shoulder

Journal Article Journal of Embryology & Stem Cell Research · October 22, 2019 Introduction:Intraarticular injections of platelet rich plasma (PRP) and adipose-derived mesenchymalstem cells (AD-MSCs) have individually shown potential benefit in the treatment of intraarticular pathology of the knee, hip and shoulder. ... Link to item Cite

Establishing an Antimicrobial Stewardship Collaborative Across a Large, Diverse Health Care System.

Journal Article Joint Commission journal on quality and patient safety · September 2019 Alarming trends in antibiotic resistance sparked a National Action Plan endorsing antimicrobial stewardship programs (ASPs) in health care facilities. Atrium Health consists of 28 acute care facilities with varying levels of ASP maturity. The organization ... Full text Cite

Predictors of Radiographic Osteoarthritis 2 to 3 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON On-site Nested Cohort.

Journal Article Orthopaedic journal of sports medicine · August 2019 BackgroundMultiple studies have shown that patients are susceptible to posttraumatic osteoarthritis (PTOA) after an anterior cruciate ligament (ACL) injury, even with ACL reconstruction (ACLR). Prospective studies using multivariable analysis to i ... Full text Cite

Anterior and Rotational Knee Laxity Does Not Affect Patient-Reported Knee Function 2 Years After Anterior Cruciate Ligament Reconstruction.

Journal Article The American journal of sports medicine · July 2019 BackgroundWhile a primary goal of anterior cruciate ligament (ACL) reconstruction is to reduce pathologically increased anterior and rotational knee laxity, the relationship between knee laxity after ACL reconstruction and patient-reported knee fu ... Full text Cite

No Difference Between Posterolateral Corner Repair and Reconstruction With Concurrent ACL Surgery: Results From a Prospective Multicenter Cohort.

Journal Article Orthop J Sports Med · July 2019 BACKGROUND: Injuries to the posterolateral corner (PLC) may occur concurrently with anterior cruciate ligament (ACL) injury. PURPOSE/HYPOTHESIS: This study evaluated the outcomes of patients who underwent operative management of PLC injuries concurrently w ... Full text Link to item Cite

Neighborhood Socioeconomic Status Affects Patient-Reported Outcome 2 Years After ACL Reconstruction.

Journal Article Orthop J Sports Med · June 2019 BACKGROUND: Lower socioeconomic status (SES) is associated with worse patient-reported outcome (PRO) after orthopaedic procedures. In patients with anterior cruciate ligament (ACL) reconstruction, evaluating SES by use of traditional measures such as years ... Full text Link to item Cite

Outcomes of Grade III Medial Collateral Ligament Injuries Treated Concurrently With Anterior Cruciate Ligament Reconstruction: A Multicenter Study.

Journal Article Arthroscopy · May 2019 PURPOSE: To evaluate differences in repair and nonoperatively managed grade III medial collateral ligament (MCL) injuries during anterior cruciate ligament (ACL) reconstruction. METHODS: Patients enrolled in a multicenter prospective longitudinal group who ... Full text Link to item Cite

Development of the KOOSglobal Platform to Measure Patient-Reported Outcomes After Anterior Cruciate Ligament Reconstruction.

Journal Article Am J Sports Med · October 2018 BACKGROUND: The Knee injury and Osteoarthritis Outcome Score (KOOS) has demonstrated inferior psychometric properties when compared with the International Knee Documentation Committee (IKDC) subjective knee form when assessing outcomes after anterior cruci ... Full text Link to item Cite

Effect of High-Grade Preoperative Knee Laxity on 6-Year Anterior Cruciate Ligament Reconstruction Outcomes.

Journal Article Am J Sports Med · October 2018 BACKGROUND: Knee laxity in the setting of anterior cruciate ligament (ACL) injury is often assessed through physical examination using the Lachman, pivot shift, and anterior drawer tests. The degree of laxity noted on these examinations may influence treat ... Full text Link to item Cite

Differences in the Lateral Compartment Joint Space Width After Anterior Cruciate Ligament Reconstruction: Data From the MOON Onsite Cohort.

Journal Article The American journal of sports medicine · March 2018 BackgroundAnterior cruciate ligament (ACL) reconstruction can effectively return athletes to the playing field, but they are still at risk of developing posttraumatic osteoarthritis (PTOA). No studies have used multivariable analysis to evaluate t ... Full text Cite

Ten-Year Outcomes and Risk Factors After Anterior Cruciate Ligament Reconstruction: A MOON Longitudinal Prospective Cohort Study.

Journal Article Am J Sports Med · March 2018 BACKGROUND: The long-term prognosis and risk factors for quality of life and disability after anterior cruciate ligament (ACL) reconstruction remain unknown. Hypothesis/Purpose: Our objective was to identify patient-reported outcomes and patient-specific r ... Full text Link to item Cite

Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study.

Journal Article Biomed Res Int · 2018 BACKGROUND: The majority of patients develop posttraumatic osteoarthritis within 15 years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative biomarkers have been associated with both pain and the progression of osteoarthritis; ... Full text Open Access Link to item Cite

Change in Anterior Cruciate Ligament Graft Choice and Outcomes Over Time.

Journal Article Arthroscopy · November 2017 PURPOSE: To analyze failure rate in 2-year increments to determine if graft choice changed over time and graft failure rate. METHODS: A prospective 2002-2008 database was used to identify risk factors for anterior cruciate ligament (ACL) retear. Subjects w ... Full text Link to item Cite

Are Bone Bruise Characteristics and Articular Cartilage Pathology Associated with Inferior Outcomes 2 and 6 Years After Anterior Cruciate Ligament Reconstruction?

Journal Article Cartilage · April 2017 Objective To determine (1) if bone bruise characteristics seen on magnetic resonance imaging are associated with patient-reported outcomes prior to and following anterior cruciate ligament reconstruction and (2) if the combined presence of bone bruises wit ... Full text Cite

Logistical challenges and design considerations for studies using acute anterior cruciate ligament injury as a potential model for early posttraumatic osteoarthritis.

Journal Article J Orthop Res · March 2017 Anterior cruciate ligament (ACL) injuries are common and lead to posttraumatic osteoarthritis (PTOA) in a high percentage of patients. Research has been ineffective in identifying successful treatment options for people suffering from symptomatic PTOA resu ... Full text Link to item Cite

Does the Chronicity of Anterior Cruciate Ligament Ruptures Influence Patient-Reported Outcomes Before Surgery?

Journal Article Am J Sports Med · March 2017 BACKGROUND: The time between an anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) may influence baseline knee-related and general health-related patient-reported outcome measures (PROMs). Despite the common use of PROMs as main outcomes ... Full text Link to item Cite

Biomarkers on the Day of ACL Reconstruction and Sex Predictive of Knee-related Quality of Life at 2-year Follow-up

Journal Article Orthopaedic journal of sports medicine · March 2017 Objectives: Regardless of surgical or conservative management, the majority of patients develop posttraumatic osteoarthritis (PTOA) within 15 years of anterior cruciate ligament (ACL) injury. In addition to MRI or radiographic evidence of cartilag ... Cite

A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear.

Journal Article Am J Sports Med · February 2017 BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression from an ... Full text Link to item Cite

Hiding in Plain Sight: Observations from a Review of Positive Urine Cultures Prior to an Antimicrobial Stewardship Program Campaign Targeting Asymptomatic Bacteriuria

Journal Article Open forum infectious diseases · January 2017 Abstract Background Data have shown that many patients with asymptomatic bacteriuria (ASB) receive unnecessary antibiotics, increasing risk of adverse events and resistance. Positive urine culture (PUC) and urinalysis (UA) results have been shown ... Cite

Effect of High-Grade Preoperative Knee Laxity on Anterior Cruciate Ligament Reconstruction Outcomes.

Journal Article Am J Sports Med · December 2016 BACKGROUND: Knee laxity in the setting of suspected anterior cruciate ligament (ACL) injury is frequently assessed through physical examination using the Lachman, pivot-shift, and anterior drawer tests. The degree of laxity noted on these examinations may ... Full text Link to item Cite

Predictors and Outcomes of Crossover to Surgery from Physical Therapy for Meniscal Tear and Osteoarthritis: A Randomized Trial Comparing Physical Therapy and Surgery.

Journal Article The Journal of bone and joint surgery. American volume · November 2016 BackgroundArthroscopic partial meniscectomy (APM) combined with physical therapy (PT) have yielded pain relief similar to that provided by PT alone in randomized trials of subjects with a degenerative meniscal tear. However, many patients randomiz ... Full text Cite

Predictors of Lateral Compartment Joint Space Difference at a Minimum of Two Years after ACL Reconstruction : Data from the Moon Onsite Cohort

Journal Article Orthopaedic journal of sports medicine · July 2016 Objectives: ACL reconstruction effectively restores knee stability and allows a return to athletic activities after ACL injury, but patients are still at higher risk of developing post-traumatic OA. Patient reported outcomes from the Multicenter O ... Cite

Does Choosing Autograft Hamstring vs. Patellar Tendon by Gender, Sport, Level of Competition or Laxity in High School and College Aged Athletes Improve KOOS, IKDC or Marx?

Journal Article Orthopaedic journal of sports medicine · July 2016 Objectives: Physicians’ and patients’ decision-making process between autograft hamstring (HG) vs. patellar tendon (BTB) for ACL reconstruction (ACLR) may be influenced by patient gender, laxity level, sport played, and/or competition level in the ... Cite

Factors Associated With High-Grade Lachman, Pivot Shift, and Anterior Drawer at the Time of Anterior Cruciate Ligament Reconstruction.

Journal Article Arthroscopy · June 2016 PURPOSE: To determine which patient and injury factors are associated with the detection of high-grade laxity on examination under anesthesia before anterior cruciate ligament (ACL) reconstruction. METHODS: We identified 2,318 patients who underwent primar ... Full text Link to item Cite

The Fate of Meniscus Tears Left In Situ at the Time of Anterior Cruciate Ligament Reconstruction: A 6-Year Follow-up Study From the MOON Cohort.

Journal Article Am J Sports Med · November 2015 BACKGROUND: The management of meniscus tears identified at the time of primary anterior cruciate ligament (ACL) reconstruction is highly variable and includes repair, meniscectomy, and nontreatment. HYPOTHESIS/PURPOSE: The purpose of this study was to dete ... Full text Link to item Cite

Risk Factors and Predictors of Subsequent ACL Injury in Either Knee After ACL Reconstruction: Prospective Analysis of 2488 Primary ACL Reconstructions From the MOON Cohort.

Journal Article Am J Sports Med · July 2015 BACKGROUND: Anterior cruciate ligament (ACL) reinjury results in worse outcomes and increases the risk of posttraumatic osteoarthritis. PURPOSE: To identify the risk factors for both ipsilateral and contralateral ACL tears after primary ACL reconstruction ... Full text Link to item Cite

Modification of Practice Patterns after Analysis of Risk Factors Improved ACLR Outcomes

Journal Article Orthopaedic journal of sports medicine · July 2015 Objectives: Retear of an ACL after an ACL reconstruction (ACLR) is devastating for all involved. Understanding risk factors and predictors of subsequent graft tear after an ACLR is vital for patient education of subsequent risk of injury and if mo ... Cite

Effect of High-Grade Pre-operative Knee Laxity on Outcomes of Anterior Cruciate Ligament Reconstruction

Journal Article Orthopaedic journal of sports medicine · July 2015 Objectives: Knee laxity in the setting of suspected anterior cruciate ligament (ACL) injury is frequently assessed through physical examination using the Lachman, pivot-shift, and anterior drawer tests. The degree of laxity noted on these examinat ... Cite

The Fate Of Meniscus Tears Left in situ At The Time Of Anterior Cruciate Ligament Reconstruction : A 6-year Follow-up Study From The Moon Cohort

Journal Article Orthopaedic journal of sports medicine · July 2015 Objectives: Meniscus tears frequently accompany acute anterior cruciate ligament ruptures. Management of meniscus tears is highly variable and includes repair, meniscectomy, and non-treatment of tears identified at the time of ACL reconstruction. ... Cite

Impact of Preoperative Expectations and Fear of Movement on Return to Sport and KOOS Scores at 6 Months following ACL Reconstruction

Journal Article Orthopaedic journal of sports medicine · July 2015 Objectives: Limited research has examined the independent relationship between psychosocial factors and patient-reported outcomes during the early postoperative period following ACL reconstruction (ACLR). The purpose of this study was to examine t ... Cite

Anterior Cruciate Ligament Reconstruction Rehabilitation: MOON Guidelines.

Journal Article Sports Health · May 2015 CONTEXT: Anterior cruciate ligament (ACL) reconstruction rehabilitation has evolved over the past 20 years. This evolution has been driven by a variety of level 1 and level 2 studies. EVIDENCE ACQUISITION: The MOON Group is a collection of orthopaedic surg ... Full text Link to item Cite

Baseline predictors of health-related quality of life after anterior cruciate ligament reconstruction: a longitudinal analysis of a multicenter cohort at two and six years.

Journal Article J Bone Joint Surg Am · April 1, 2015 BACKGROUND: Limited information exists regarding predictors of general quality of life following anterior cruciate ligament (ACL) reconstruction with up to six-year follow-up. We hypothesized that certain variables evaluated at the time of ACL reconstructi ... Full text Link to item Cite

Meniscus treatment and age associated with narrower radiographic joint space width 2-3 years after ACL reconstruction: data from the MOON onsite cohort.

Journal Article Osteoarthritis and cartilage · April 2015 ObjectiveTo identify risk factors for radiographic signs of post-traumatic osteoarthritis (OA) 2-3 years after anterior cruciate ligament (ACL) reconstruction through multivariable analysis of minimum joint space width (mJSW) differences in a spec ... Full text Cite

The Impact of the Multicenter Orthopaedic Outcomes Network (MOON) Research on Anterior Cruciate Ligament Reconstruction and Orthopaedic Practice.

Journal Article J Am Acad Orthop Surg · March 2015 With an estimated 200,000 anterior cruciate ligament reconstructions performed annually in the United States, there is an emphasis on determining patient-specific information to help educate patients on expected clinically relevant outcomes. The Multicente ... Full text Link to item Cite

Cost-Effectiveness Analysis of Early Reconstruction Versus Rehabilitation and Delayed Reconstruction for Anterior Cruciate Ligament Tears.

Journal Article Am J Sports Med · July 2014 BACKGROUND: An initial anterior cruciate ligament (ACL) tear can be treated with surgical reconstruction or focused rehabilitation. The KANON (Knee Anterior cruciate ligament, NON-surgical versus surgical treatment) randomized controlled trial compared reh ... Full text Link to item Cite

Risk Factors and Predictors Of Subsequent ACL Injury After ACL Reconstruction: Prospective Analysis Of 2801 Primary ACL Reconstructions

Journal Article Orthopaedic journal of sports medicine · July 2014 Objectives: Retear of an ACL after an ACL reconstruction (ACLR) is devastating for all involved. Understanding risk factors and predictors of subsequent ACL tear after an ACLR is vital for patient education of subsequent risk of injury and if a pr ... Cite

Are articular cartilage lesions and meniscus tears predictive of IKDC, KOOS, and Marx activity level outcomes after anterior cruciate ligament reconstruction? A 6-year multicenter cohort study.

Journal Article Am J Sports Med · May 2014 BACKGROUND: Identifying risk factors for inferior outcomes after anterior cruciate ligament reconstruction (ACLR) is important for prognosis and future treatment. HYPOTHESIS: Articular cartilage lesions and meniscus tears/treatment would predict Internatio ... Full text Link to item Cite

Do newer-generation bioabsorbable screws become incorporated into bone at two years after ACL reconstruction with patellar tendon graft?: A cohort study.

Journal Article The Journal of bone and joint surgery. American volume · February 2014 BackgroundBioabsorbable interference screws are used frequently for graft fixation in ACL (anterior cruciate ligament) reconstruction. The resorption properties of many available screws that are marketed as bioabsorbable are not well defined. The ... Full text Cite

Arthroscopic partial meniscectomy was not more effective than physical therapy for meniscal tear and knee osteoarthritis.

Journal Article The Journal of bone and joint surgery. American volume · November 2013 Full text Cite

The rate of subsequent surgery and predictors after anterior cruciate ligament reconstruction: two- and 6-year follow-up results from a multicenter cohort.

Journal Article Am J Sports Med · July 2013 BACKGROUND: Subsequent surgeries have a profound effect on patient satisfaction and outcome after primary anterior cruciate ligament reconstruction (ACLR). There have been no prospective studies to date describing the rate and predictors (surgical and pati ... Full text Link to item Cite

Surgery versus physical therapy for a meniscal tear and osteoarthritis.

Journal Article The New England journal of medicine · May 2013 BackgroundWhether arthroscopic partial meniscectomy for symptomatic patients with a meniscal tear and knee osteoarthritis results in better functional outcomes than nonoperative therapy is uncertain.MethodsWe conducted a multicenter, rand ... Full text Cite

Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studies.

Journal Article J Orthop Res · January 2013 Injury to the anterior cruciate ligament (ACL) threatens an active lifestyle and exposes the patient to risk of early osteoarthritis (OA). ACL reconstruction is typically chosen by individuals to allow a return to their previous work and sports activities. ... Full text Link to item Cite

Return to high school- and college-level football after anterior cruciate ligament reconstruction: a Multicenter Orthopaedic Outcomes Network (MOON) cohort study.

Journal Article Am J Sports Med · November 2012 BACKGROUND: There is a relative paucity of data regarding the effect of anterior cruciate ligament (ACL) reconstruction on the ability of American high school and collegiate football players to return to play at the same level of competition as before thei ... Full text Link to item Cite

Multi-investigator collaboration in orthopaedic surgery research compared to other medical fields.

Journal Article Journal of orthopaedic research : official publication of the Orthopaedic Research Society · October 2012 An increasing emphasis has been placed across health care on evidence-based medicine with higher level studies, such as randomized trials and prospective cohort studies. Historically, clinical research in orthopaedic surgery has been dominated by studies w ... Full text Cite

Hop tests correlate with IKDC and KOOS at minimum of 2 years after primary ACL reconstruction.

Journal Article Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · November 2011 PurposeThe hypothesis of this study was that single-legged horizontal hop test ratios would correlate with IKDC, KOOS, and Marx activity level scores in patients 2 years after primary ACL reconstruction.MethodsIndividual patient-reported ... Full text Cite

The prognosis and predictors of sports function and activity at minimum 6 years after anterior cruciate ligament reconstruction: a population cohort study.

Journal Article Am J Sports Med · February 2011 BACKGROUND: The predictors of anterior cruciate ligament reconstruction (ACLR) outcome at 6 years as measured by validated patient-based outcome instruments are unknown. HYPOTHESIS: Certain variables evaluated at the time of ACLR will predict return to spo ... Full text Link to item Cite

Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner.

Journal Article Journal of immunology (Baltimore, Md. : 1950) · November 2008 Multiple sclerosis and an animal model resembling multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating diseases of the CNS that are suppressed by systemic mycobacterial infection in mice and BCG vaccination in ... Full text Cite

Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms.

Journal Article Journal of neuroimmunology · May 2007 The homophilic cell adhesion molecule PECAM-1 is a major participant in the migration of leukocytes across endothelium. We examined the ability of a chimeric soluble PECAM-1 fused to human IgG-Fc to impair leukocyte entry through the blood-brain barrier an ... Full text Cite

Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases.

Journal Article Journal of immunology (Baltimore, Md. : 1950) · January 2007 Dendritic cells (DCs) accumulate in the CNS during inflammatory diseases, but the exact mechanism regulating their traffic into the CNS remains to be defined. We now report that MIP-1alpha increases the transmigration of bone marrow-derived, GFP-labeled DC ... Full text Cite

Dendritic cells in the CNS: Immune regulators and therapeutic targets for multiple sclerosis treatment

Journal Article Future Neurology · January 1, 2007 Dendritic cells (DCs) are essential antigen-presenting cells responsible for initiating cellular immune responses. The increasing interest in the mechanisms of DC trafficking has created new and exciting opportunities for bench-to-bedside therapies to trea ... Full text Cite

Substance P receptor mediated maintenance of chronic inflammation in EAE.

Journal Article Journal of neuroimmunology · November 2006 Substance P (SP) is a modulatory, pro-inflammatory neuropeptide. We investigated the role of the SP receptor, neurokinin-1 (NK-1), in EAE. Our data show that in the chronic phase, mice lacking NK-1 have improved mobility and decreased numbers of LFA-1 high ... Full text Cite

Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells.

Journal Article Neurobiology of aging · June 2006 Overproduction of amyloid precursor protein (APP) and beta-amyloid likely contribute to neurodegeneration in Alzheimer's disease (AD). In an effort to understand neuronal APP gene regulation, we identified a 52 base element (52sce) immediately downstream f ... Full text Cite

Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides.

Journal Article Immunology letters · April 2006 Immune privilege in the central nervous system (CNS) is not maintained by immune ignorance of the CNS, but by CNS control over inflammatory processes. In this review we examine the role neuropeptides play in maintenance of immune privilege in the CNS. Vaso ... Full text Cite

Persistence of zinc-binding bacterial superantigens at the surface of antigen-presenting cells contributes to the extreme potency of these superantigens as T-cell activators.

Journal Article Infection and immunity · September 2005 Bacterial superantigen intoxication causes massive overactivation of T cells, which can result in potentially lethal toxic shock. Superantigens fall into two groups: superantigens such as staphylococcal enterotoxin B (SEB) that contain a single generic bin ... Full text Cite

T-Cell migration across the blood-brain barrier in CNS inflammatory diseases

Chapter · January 1, 2005 T-cell migration into the central nervous system (CNS) is a critical element in infiammatory and autoimmune diseases of the nervous tissue. Although several components involved in this process have been identified, we still lack a complete understanding of ... Cite

Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis.

Journal Article Clinical and diagnostic laboratory immunology · July 2003 Infectious agents have been proposed to influence susceptibility to autoimmune diseases such as multiple sclerosis. We induced a Th1-mediated central nervous system (CNS) autoimmune disease, experimental autoimmune encephalomyelitis (EAE) in mice with an o ... Full text Cite

Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization.

Journal Article International immunology · January 2003 Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS) characterized by chronic inflammatory demyelination of the central nervous system (CNS). The pathology of EAE involves autoimmune CD4(+) T(h)1 cells. There is a ... Full text Cite

Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.

Conference Immunology letters · June 2002 The 'hygiene hypothesis' has been proposed to explain apparent increases in autoimmune disease and allergy in areas of the world with improved health care and sanitation. This hypothesis proposes that the lack of serious childhood infections impairs develo ... Full text Cite

High-affinity, protective antibodies to the binding domain of botulinum neurotoxin type A.

Journal Article Infection and immunity · January 2001 Monoclonal antibodies (MAbs) were prepared against the putative binding domain of botulinum neurotoxin A (BoNT/A), a nontoxic 50-kDa fragment. Initially, all fusion products were screened against the holotoxin BoNT/A and against the binding fragment, BoNT/ ... Full text Cite