Scholars@Duke
Eric D. Carlsen

Eric D. Carlsen

Associate Professor of Pathology
Pathology
eric.carlsen@duke.edu
40 Duke Medicine Circle, Durham, NC 27710

Selected Publications

Distinct B/myeloid and T-lymphoblast populations at separate anatomic sites in mixed-phenotype acute leukemia with BCR::ABL1 fusion.

Journal Article J Hematop · September 22, 2025 The pluripotency of malignant blasts in acute leukemias is a growing area of scientific and clinical interest. Mixed-phenotype acute leukemias (MPALs) are defined by the presence of blasts showing evidence of differentiation along at least two lineages. Cu ... Full text Open Access Link to item Cite

Characteristics of isatuximab-derived interference in serum protein electrophoresis and immunofixation, and an absence of sustained in vivo interference due to belantamab mafodotin and denosumab.

Journal Article Clin Biochem · May 2024 OBJECTIVES: Some therapeutic monoclonal antibodies, like daratumumab and elotuzumab, produce interfering monoclonal bands on serum protein electrophoresis (SPEP) and immunofixation electrophoresis (IFE). Whether other common therapeutic antibodies also pro ... Full text Link to item Cite

Flow cytometry quantification of tumor-infiltrating lymphocytes to predict the survival of patients with diffuse large B-cell lymphoma.

Journal Article Front Immunol · 2024 INTRODUCTION: Our previous studies have demonstrated that tumor-infiltrating lymphocytes (TILs), including normal B cells, T cells, and natural killer (NK) cells, in diffuse large B-cell lymphoma (DLBCL) have a significantly favorable impact on the clinica ... Full text Open Access Link to item Cite

The Distinctive Nature of Thyroid MALT Lymphomas Including IRTA1 Expression.

Journal Article Am J Surg Pathol · March 1, 2023 Mucosa-associated lymphoid tissue (MALT) lymphomas often express IgM and IRTA1 with only a minority demonstrating plasmacytic differentiation. However, like primary cutaneous marginal zone lymphoproliferative disorders (PCMZLPD), thyroid MALT lymphomas (T- ... Full text Link to item Cite

Marrow cryptococcosis in an autologous stem cell transplant patient after standard therapy for cryptococcal meningitis

Journal Article Journal of Hematopathology · December 1, 2022 The patient is a woman in her 60s with a history of plasma cell myeloma, status post high-dose melphalan and autologous stem cell transplant, followed by maintenance lenalidomide. She was admitted for severe headaches with concern for meningitis. CSF cultu ... Full text Cite

Characterization of Casirivimab Plus Imdevimab, Sotrovimab, and Bamlanivimab Plus Etesevimab-Derived Interference in Serum Protein Electrophoresis and Immunofixation Electrophoresis.

Journal Article J Appl Lab Med · October 29, 2022 BACKGROUND: Therapeutic monoclonal antibodies can be a source of assay interference in clinical serum protein electrophoresis (SPEP) and immunofixation electrophoresis (IFE), producing monoclonal bands that can be misinterpreted as a monoclonal gammopathy ... Full text Open Access Link to item Cite

IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.

Journal Article J Cutan Pathol · January 2022 BACKGROUND: It has been proposed that primary cutaneous marginal zone lymphomas (PCMZLs) include a MALT-lymphoma-like IgM+ subset and a class-switched subset, which is unlike most other MALT lymphomas. Whether expression of the MALT lymphoma-associated bio ... Full text Link to item Cite

Clinicopathologic Characterization of Hypocellular Acute Myeloid Leukemia (AML) Showed Fewer Genetic Abnormalities Involving Cell Proliferation and NPM1 When Compared With Nonhypocellular AML

Journal Article American Journal of Clinical Pathology · February 11, 2021 AbstractObjectivesHypocellular acute myeloid leukemia (AML) is uncommon. Despite the prognostic and therapeutic importance of mutation ... Full text Cite

Class-switched Primary Cutaneous Marginal Zone Lymphomas Are Frequently IgG4-positive and Have Features Distinct From IgM-positive Cases

Journal Article American Journal of Surgical Pathology · October 2019 Primary cutaneous marginal zone lymphoma (PCMZL) can be subdivided into 2 groups based on immunoglobulin (Ig) heavy chain usage: IgM-positive cases that constitute a less common and more T-helper type 1–driven process, and more common heavy chain c ... Full text Cite

Utilization of GC-MS to Confirm Etiology in a Case of New-Onset Coagulopathy

Journal Article The Journal of Applied Laboratory Medicine · September 1, 2018 Full text Cite

mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production

Journal Article The Journal of Immunology · May 15, 2016 AbstractIt has been shown recently that neutrophils are able to produce IL-22 and IL-17, which differentially regulate the pathogenesis of inflammatory bowel disease. However, it is still largely unknown how ... Full text Cite

Permissive and protective roles for neutrophils in leishmaniasis

Journal Article Clinical and Experimental Immunology · October 13, 2015 SummaryLeishmania parasites are the causative agents of leishmaniasis, a neglected tropical disease that causes substantial morbidity and considerable mortality in many developing areas of the world. Recent estimates sugges ... Full text Cite

Interactions between Neutrophils and <b><i>Leishmania braziliensis</i></b> Amastigotes Facilitate Cell Activation and Parasite Clearance

Journal Article Journal of Innate Immunity · 2015 <i>Leishmania braziliensis</i> and <i>Leishmania amazonensis</i> are both causative agents of cutaneous leishmaniasis in South America. However, patient prognosis and the host immune response differ considerably depending on ... Full text Cite

Hepatocyte growth factor in dampening liver immune‐mediated pathology in acute viral hepatitis without compromising antiviral activity

Journal Article Journal of Gastroenterology and Hepatology · April 2014 AbstractBackground and AimHepatocyte growth factor (HGF) is a pleiotropic cytokine related with cell proliferation and surviva ... Full text Cite

Downregulation of micro‐107 in intestinal 11c+ myeloid cells in response to microbiota and proinflammatory cytokines increases ‐23p19 expression

Journal Article European Journal of Immunology · March 2014 Commensal flora plays an important role in the development of the mucosal immune system and in maintaining intestinal homeostasis. However, the mechanisms involved in regulation of host‐microbiota interaction are still not completely understood. In ... Full text Cite

Leishmania amazonensis Amastigotes Trigger Neutrophil Activation but Resist Neutrophil Microbicidal Mechanisms

Journal Article Infection and Immunity · November 2013 ABSTRACT Neutrophils are the first cells to infiltrate to the site of Leishm ... Full text Cite

Immunomodulatory and Antibacterial Effects of Cystatin 9 against Francisella tularensis

Journal Article Molecular Medicine · January 2013 AbstractCystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory effects that restrain inflammation, but its functions against bacterial infections are un ... Full text Cite

Differential Microbicidal Effects of Human Histone Proteins H2A and H2B on Leishmania Promastigotes and Amastigotes

Journal Article Infection and Immunity · March 2011 ABSTRACT Recent studies have shown that histone proteins can act as antimicrobial peptides in host defense against extracellular bacteria, fungi, and Leishmania ... Full text Cite