Scholars@Duke
Felix De bie

Felix De bie

House Staff
Surgery

Selected Publications

High-fidelity, low-cost synthetic training model for fetoscopic spina bifida repair.

Journal Article American journal of obstetrics & gynecology MFM · March 2024 BackgroundFetoscopic spina bifida repair is increasingly being practiced, but limited skill acquisition poses a barrier to widespread adoption. Extensive training in relevant models, including both ex vivo and in vivo models may help. To address t ... Full text Cite

Prenatal treprostinil improves pulmonary arteriolar hypermuscularization in the rabbit model of congenital diaphragmatic hernia.

Journal Article Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · January 2024 Congenital diaphragmatic hernia (CDH) is a congenital malformation characterized by pulmonary hypoplasia, pulmonary hypertension, and cardiac dysfunction. Pulmonary hypertension represents the major cause of neonatal mortality and morbidity. Prenatal diagn ... Full text Cite

The artificial placenta and EXTEND technologies: one of these things is not like the other.

Journal Article Journal of perinatology : official journal of the California Perinatal Association · November 2023 The so called "Artificial Placenta" and "Artificial Womb" (EXTEND) technologies share a common goal of improving outcomes for extreme premature infants. Beyond that goal, they are very dissimilar and, in our view, differ sufficiently in their technology, i ... Full text Cite

Duration of fetoscopic spina bifida repair does not affect the central nervous system in fetal lambs.

Journal Article American journal of obstetrics & gynecology MFM · November 2023 BackgroundPrenatal spina bifida aperta repair improves neurologic outcomes yet comes with a significant risk of prematurity and uterine scar-related complications. To reduce such complications, different fetoscopic techniques, for example, with va ... Full text Cite

Core outcome set for perinatal interventions for congenital diaphragmatic hernia.

Journal Article Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · September 2023 ObjectiveTo develop a core set of prenatal and neonatal outcomes for clinical studies evaluating perinatal interventions for congenital diaphragmatic hernia, using a validated consensus-building method.MethodsAn international steering gro ... Full text Cite

Treprostinil in Neonates with Congenital Diaphragmatic Hernia-Related Pulmonary Hypertension.

Journal Article The Journal of pediatrics · August 2023 ObjectiveTo describe our experience with treprostinil, evaluate correlations with cardiac function, and assess for adverse effects in neonates with congenital diaphragmatic hernia-related pulmonary hypertension (CDH-PH).Study designA retr ... Full text Cite

Maternal-fetal surgery as part of pediatric palliative care.

Journal Article Semin Fetal Neonatal Med · June 2023 Maternal-fetal surgical interventions have become a more common part of prenatal care. This third option, beside termination or post-natal interventions, complicates prenatal decision-making: while interventions may be lifesaving, survivors may face a life ... Full text Link to item Cite

Ethics Considerations Regarding Artificial Womb Technology for the Fetonate.

Journal Article The American journal of bioethics : AJOB · May 2023 Since the early 1980's, with the clinical advent of in vitro fertilization resulting in so-called "test tube babies," a wide array of ethical considerations and concerns regarding artificial womb technology (AWT) have been described. Recent breakthroughs i ... Full text Cite

Long-term outcomes of bilateral thoracoscopic T3 sympathectomy for primary focal hyperhidrosis in children.

Journal Article Journal of pediatric surgery · January 2023 BackgroundThoracoscopic bilateral T3 sympathectomy for primary focal palmar hyperhidrosis in children has excellent short-term outcomes. However, data in the literature, on the long-term outcomes of the operation are scarce.MethodsWe cond ... Full text Cite

Neonatal and fetal therapy of congenital diaphragmatic hernia-related pulmonary hypertension.

Journal Article Archives of disease in childhood. Fetal and neonatal edition · September 2022 Congenital diaphragmatic hernia (CDH) is a complex malformation characterised by a triad of pulmonary hypoplasia, pulmonary hypertension (PH) and cardiac ventricular dysfunction. Much of the mortality and morbidity in CDH is largely accounted for by PH, es ... Full text Cite

Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations.

Journal Article International journal of environmental research and public health · September 2022 Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical ... Full text Cite

Prenatal treprostinil reduces the pulmonary hypertension phenotype in the rat model of congenital diaphragmatic hernia.

Journal Article EBioMedicine · July 2022 BackgroundPersistent pulmonary hypertension (PH) causes significant mortality and morbidity in infants with congenital diaphragmatic hernia (CDH). Since pulmonary vascular abnormalities in CDH develop early during foetal development, we hypothesiz ... Full text Cite

The EXTrauterine Environment for Neonatal Development: Present and Future.

Journal Article Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society · May 2022 Despite advances in clinical care and modest improvement in mortality rates for extreme prematurity, morbidity remains a significant challenge. The ideal environment to support prematurity would be fluidic and rely on natural fetal circulation to mimic the ... Full text Cite

Pneumatosis intestinalis in children beyond the neonatal period: is it always benign?

Journal Article Pediatric surgery international · March 2022 PurposeThe significance and management of pediatric pneumatosis intestinalis (PI) remains poorly defined. We sought to add clarity in children beyond the neonatal period.MethodsPediatric patients 3 months-18 years admitted to a quaternary ... Full text Cite

An Examination of General Surgery Residency Programs with a Rural Track.

Journal Article Journal of surgical education · March 2022 BackgroundThere is a steady decline in the general surgery workforce in rural areas of the United States. In response, some surgery residency programs have developed rural tracks to encourage rural practice and adequately prepare trainees for this ... Full text Cite

Fetoscopic insufflation of heated-humidified carbon dioxide during simulated spina bifida repair is safe under controlled anesthesia in the fetal lamb.

Journal Article Prenatal diagnosis · February 2022 ObjectiveTo assess the safety of Partial-Amniotic-Insufflation-of-heated-humidified-CO2 (hPACI) during fetoscopic spina bifida repair (fSB-repair).MethodA simulated fSB-repair through an exteriorized uterus under hPACI was perf ... Full text Cite

Prenatal treprostinil crosses the placenta in rats and is well tolerated by mother and fetus

Conference AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · 2022 Cite

Pharmacokinetics and pharmacodynamics of sildenafil in fetal lambs on extracorporeal support.

Journal Article Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · November 2021 BackgroundMaternal transplacental administration of sildenafil is being considered for a variety of fetal conditions. Clinical translation also requires evaluation of fetal safety in a higher species, such as the fetal lamb. Experiments with the p ... Full text Cite

Long-term core outcomes of patients with simple gastroschisis.

Journal Article Journal of pediatric surgery · August 2021 PurposeTo report the long-term core outcome set of patients with simple gastroschisis.MethodsThis was a retrospective chart review of all patients with simple gastroschisis managed at our hospital between August 2008 and July 2016. We col ... Full text Cite

In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease.

Journal Article Nature communications · July 2021 In utero base editing has the potential to correct disease-causing mutations before the onset of pathology. Mucopolysaccharidosis type I (MPS-IH, Hurler syndrome) is a lysosomal storage disease (LSD) affecting multiple organs, often leading to early postna ... Full text Cite

Validation of a high-fidelity training model for fetoscopic spina bifida surgery.

Journal Article Scientific reports · March 2021 Open fetal surgery for spina bifida (SB) is safe and effective yet invasive. The growing interest in fetoscopic SB repair (fSB-repair) prompts the need for appropriate training. We aimed to develop and validate a high-fidelity training model for fSB-repair ... Full text Cite

Study protocol: a core outcome set for perinatal interventions for congenital diaphragmatic hernia.

Journal Article Trials · February 2021 BackgroundCongenital diaphragmatic hernia (CDH) is, depending of the severity, a birth defect associated with significant mortality and morbidity. Prenatal screening by ultrasound may detect this condition and comprehensive assessment of severity ... Full text Cite

Fetoscopic insufflation modeled in the extrauterine environment for neonatal development (EXTEND): Fetoscopic insufflation is safe for the fetus.

Journal Article Journal of pediatric surgery · January 2021 BackgroundMinimally invasive fetal surgery, or fetoscopy, is an alternative to open fetal surgery to repair common birth defects like myelomeningocele. Although this hysterotomy-sparing approach reduces maternal morbidity, the effects of in utero ... Full text Cite

Artificial placenta and womb technology: Past, current, and future challenges towards clinical translation.

Journal Article Prenatal diagnosis · January 2021 Extreme prematurity remains a major cause of neonatal mortality and severe long-term morbidity. Current neonatal care is associated with significant morbidity due to iatrogenic injury and developmental immaturity of extreme premature infants. A more physio ... Full text Cite

Transplacental Transfer and Fetal Pharmacodynamics of Sildenafil in the Pregnant Sheep Model.

Journal Article Fetal diagnosis and therapy · January 2021 BackgroundSildenafil is a phosphodiesterase-5 inhibitor considered for antenatal use for a variety of indications. We sought to assess sildenafil pharmacokinetics in the pregnant ewe and fetus and evaluate its physiological fetal effects.Metho ... Full text Cite

Treprostinil Attains Clinically Therapeutic Concentrations in Neonates with Pulmonary Hypertension on Extracorporeal Membrane Oxygenation Support.

Journal Article Pharmacotherapy · October 2020 BackgroundTREPROSTINIL IS A PROSTACYCLIN ANALOG USED FOR TREATMENT OF PULMONARY HYPERTENSION (PH) IN ADULTS AND CHILDREN, CURRENTLY AWAITING CLINICAL ASSESSMENT FOR USE IN NEONATES.: OBJECTIVES: WE AIMED TO INVESTIGATE THE USE OF TREPROSTINIL IN N ... Full text Cite

Early surgical complications after congenital diaphragmatic hernia repair by thoracotomy vs. laparotomy: A bicentric comparison.

Journal Article Journal of pediatric surgery · October 2020 PurposeThe surgical strategy for congenital diaphragmatic hernia (CDH) repair remains debated and mainly depends on the training and preference of the surgeon. Our aim was to evaluate the occurrence and nature of surgical reinterventions within th ... Full text Cite

Reply.

Journal Article Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · October 2020 Full text Cite

Learning curves of open and endoscopic fetal spina bifida closure: systematic review and meta-analysis.

Journal Article Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · June 2020 ObjectiveThe Management of Myelomeningocele Study (MOMS) trial demonstrated the safety and efficacy of open fetal surgery for spina bifida aperta (SBA). Recently developed alternative techniques may reduce maternal risks without compromising the f ... Full text Cite

Management of Pneumatosis Intestinalis beyond the Neonatal Period

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2020 Cite

Prenatal diagnosis and management of congenital diaphragmatic hernia.

Journal Article Best practice & research. Clinical obstetrics & gynaecology · July 2019 Congenital diaphragmatic hernia is characterized by failed closure of the diaphragm, thereby allowing abdominal viscera to herniate into the thoracic cavity and subsequently interfering with normal lung development. At birth, pulmonary hypoplasia leads to ... Full text Cite

Sildenafil for Antenatal Treatment of Congenital Diaphragmatic Hernia: From Bench to Bedside.

Journal Article Current pharmaceutical design · January 2019 BackgroundPersistent pulmonary hypertension (PPH) is one of the main causes of mortality and morbidity in infants affected by congenital diaphragmatic hernia (CDH). Since the structural changes that lead to PPH take place already in utero, a treat ... Full text Cite

The multi-disciplinary management of complex congenital and acquired tracheo-oesophageal fistulae.

Journal Article Pediatric surgery international · January 2019 Aim of the studyComplex tracheo-oesophageal fistulae (TOF) are rare congenital or acquired conditions in children. We discuss here a multidisciplinary (MDT) approach adopted over the past 5 years.MethodsWe retrospectively collected data o ... Full text Cite

Safety and efficacy of fetal surgery techniques to close a spina bifida defect in the fetal lamb model: A systematic review.

Journal Article Prenatal diagnosis · March 2018 ObjectiveTo determine the safety and efficacy of different neurosurgical techniques for closure of spina bifida (SB) in the fetal lamb model.MethodSystematic review of studies reporting on fetal lambs undergoing induction and closure of S ... Full text Cite