Geraldine Dawson

Journal Article Sci Rep · October 25, 2024 A concern in the field of autism electroencephalography (EEG) biomarker discovery is their lack of reproducibility. In the present study, we considered the problem of learning reproducible associations between multiple features of resting state (RS) neural ... Full text Link to item Cite

Digital Phenotyping based on a Mobile App Identifies Distinct and Overlapping Features in Children Diagnosed with Autism versus ADHD

Conference The 37th Annual ACM Symposium on User Interface Software and Technology · October 13, 2024 Full text Cite

Factors Associated with Caregivers' Decisions to Pursue a Diagnostic Evaluation After a Positive Autism Screen in Primary Care.

Journal Article J Autism Dev Disord · October 7, 2024 PURPOSE: We sought to understand whether a child's sex, age, race, ethnicity, caregiver education, family income, and/or number of endorsed autism signs are associated with a caregiver's decision to pursue an autism diagnostic evaluation after their child ... Full text Link to item Cite

Automated Video Tracking of Autistic Children's Movement During Caregiver-Child Interaction: An Exploratory Study.

Journal Article J Autism Dev Disord · October 2024 Objective, quantitative measures of caregiver-child interaction during play are needed to complement caregiver or examiner ratings for clinical assessment and tracking intervention responses. In this exploratory study, we examined the feasibility of using ... Full text Link to item Cite

Integrating tailored approaches in perioperative care strategies for neurodivergent individuals.

Journal Article EClinicalMedicine · October 2024 Neurodivergent (ND) individuals exhibit variations in communication, behaviors, and cognition, which present both opportunities and challenges in healthcare settings. Anesthesiologists can offer personalized and compassionate care to ND patients throughout ... Full text Open Access Link to item Cite

Clinician-caregiver informant discrepancy is associated with sex, diagnosis age, and intervention use among autistic children.

Journal Article Autism · September 30, 2024 In some cases, a clinician's perceptions of a child's autism-related behaviors are not the same as the child's caregiver's perceptions. Identifying how these discrepancies relate to the characteristics of the child is critical for ensuring that diagnosis p ... Full text Link to item Cite

Behavioral characteristics of toddlers later identified with an autism diagnosis, ADHD symptoms, or combined autism and ADHD symptoms.

Journal Article J Child Psychol Psychiatry · September 3, 2024 BACKGROUND: Autism commonly co-occurs with attention-deficit/hyperactivity disorder (ADHD), but less is known regarding how ADHD symptoms impact the early presentation of autism. This study examined early behavioral characteristics of a community sample of ... Full text Link to item Cite

Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms.

Journal Article J Autism Dev Disord · September 2024 Attention-deficit/hyperactivity disorder (ADHD) symptoms affect 40-60% of autistic children and have been linked to differences in adaptive behavior. It is unclear whether adaptive behavior in autistic youth is directly impacted by co-occurring ADHD sympto ... Full text Link to item Cite

Parsing evoked and induced gamma response differences in Autism: A visual evoked potential study.

Journal Article Clin Neurophysiol · September 2024 OBJECTIVE: Electroencephalography (EEG) measures of visual evoked potentials (VEPs) provide a targeted approach for investigating neural circuit dynamics. This study separately analyses phase-locked (evoked) and non-phase-locked (induced) gamma responses w ... Full text Link to item Cite

A conditional multi-label model to improve prediction of a rare outcome: An illustration predicting autism diagnosis.

Journal Article J Biomed Inform · September 2024 OBJECTIVE: This study aimed to develop a novel approach using routinely collected electronic health records (EHRs) data to improve the prediction of a rare event. We illustrated this using an example of improving early prediction of an autism diagnosis, gi ... Full text Link to item Cite

Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.

Journal Article Nat Commun · August 9, 2024 One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable genome-editing-mediated approach to target 14 high-confidence autism ri ... Full text Link to item Cite

Modeling intra-individual inter-trial EEG response variability in autism.

Journal Article Stat Med · July 30, 2024 Autism spectrum disorder (autism) is a prevalent neurodevelopmental condition characterized by early emerging impairments in social behavior and communication. EEG represents a powerful and non-invasive tool for examining functional brain differences in au ... Full text Link to item Cite

Brief Report: Relationships Between Caregiver-Reported Externalizing and Internalizing Behaviors and the Modified Checklist for Autism in Toddlers.

Journal Article J Autism Dev Disord · July 12, 2024 PURPOSE: Early detection and intervention are associated with improved outcomes for autistic children. Thus, it is important to understand factors influencing early screening tools designed to detect autism. This study examined the relationship between car ... Full text Link to item Cite

Cognitive Disengagement Syndrome in Young Autistic Children, Children with ADHD, and Autistic Children with ADHD.

Journal Article J Clin Child Adolesc Psychol · June 20, 2024 OBJECTIVE: Cognitive Disengagement Syndrome (CDS; previously called Sluggish Cognitive Tempo) refers to a constellation of cognitive and motor behaviors characterized by a predisposition toward mind wandering (cognitive subdomain) and slowed motor behavior ... Full text Link to item Cite

Computer Vision Analysis of Caregiver-Child Interactions in Children with Neurodevelopmental Disorders: A Preliminary Report.

Journal Article J Autism Dev Disord · June 2024 We report preliminary results of computer vision analysis of caregiver-child interactions during free play with children diagnosed with autism (N = 29, 41-91 months), attention-deficit/hyperactivity disorder (ADHD, N = 22, 48-100 months), or combined autis ... Full text Link to item Cite

Large-scale Validation of a Scalable and Portable Behavioral Digital Screening Tool for Autism at Home

Conference Conference on Human Factors in Computing Systems - Proceedings · May 11, 2024 Autism, characterized by challenges in socialization and communication, benefits from early detection for prompt and timely intervention. Traditional autism screening questionnaires often exhibit reduced accuracy in primary care settings and significantly ... Full text Cite

Autistic Individuals Do Not Alter Visual Processing Strategy During Encoding Versus Recognition of Faces: A Hidden Markov Modeling Approach.

Journal Article J Autism Dev Disord · March 2, 2024 PURPOSE: Visual face recognition-the ability to encode, discriminate, and recognize the faces of others-is fundamentally supported by eye movements and is a common source of difficulty for autistic individuals. We aimed to evaluate how visual processing st ... Full text Link to item Cite

Addressing the Gap in Research Training in Child Psychiatry and Neurodevelopment.

Journal Article J Am Acad Child Adolesc Psychiatry · February 2024 Psychiatric and neurodevelopmental conditions in children are common, often co-occur, and can be highly impairing. Moreover, psychiatric disorders that typically do not fully manifest until adulthood, such as schizophrenia, have their roots in early develo ... Full text Link to item Cite

Prevalence of bias against neurodivergence-related terms in artificial intelligence language models.

Journal Article Autism Res · February 2024 Given the increasing role of artificial intelligence (AI) in many decision-making processes, we investigate the presence of AI bias towards terms related to a range of neurodivergent conditions, including autism, ADHD, schizophrenia, and obsessive-compulsi ... Full text Link to item Cite

Autism Caregiver Coaching in Africa (ACACIA): Protocol for a type 1-hybrid effectiveness-implementation trial.

Journal Article PLoS One · 2024 BACKGROUND: While early autism intervention can significantly improve outcomes, gaps in implementation exist globally. These gaps are clearest in Africa, where forty percent of the world's children will live by 2050. Task-sharing early intervention to non- ... Full text Link to item Cite

Sex differences in the age of childhood autism diagnosis and the impact of co-occurring conditions.

Journal Article Autism Res · December 2023 Sex differences in the age of autism diagnosis during childhood have been documented consistently but remain poorly understood. In this study, we used electronic health records data from a diverse, academic medical center to quantify differences in the age ... Full text Link to item Cite

Prevalence and nature of prior developmental and medical concerns in toddlers who screen positive for autism in primary care.

Journal Article Autism · November 2023 The American Academy of Pediatrics recommends that all children be screened for autism at their 18- and 24-month well-child visit. For children who screen positive for autism, it is unknown whether this usually represents the first time a developmental con ... Full text Link to item Cite

Automated movement tracking of young autistic children during free play is correlated with clinical features associated with autism.

Journal Article Autism · November 2023 Play-based observations allow researchers to observe autistic children across a wide range of ages and skills. We recorded autistic children playing with toys in the center of a room and at a corner table while a caregiver remained seated off to the side a ... Full text Link to item Cite

The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) feasibility study.

Journal Article Autism Res · November 2023 The Selective Social Attention (SSA) task is a brief eye-tracking task involving experimental conditions varying along socio-communicative axes. Traditionally the SSA has been used to probe socially-specific attentional patterns in infants and toddlers who ... Full text Link to item Cite

Associations between executive function and attention abilities and language and social communication skills in young autistic children.

Journal Article Autism · October 2023 Executive functioning describes a set of cognitive processes that affect thinking and behavior. Past research has shown that autistic individuals often have delays in the acquisition of executive function abilities. Our study explored how differences in ex ... Full text Link to item Cite

Early detection of autism using digital behavioral phenotyping.

Journal Article Nat Med · October 2023 Early detection of autism, a neurodevelopmental condition associated with challenges in social communication, ensures timely access to intervention. Autism screening questionnaires have been shown to have lower accuracy when used in real-world settings, su ... Full text Link to item Cite

6.12 Home Video Analysis of Affect and Attention at 12 Months in ASD and ADHD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2023 Full text Cite

6.3 Early Motor and Communication Indicators of ASD and ADHD and Prediction of Later Skills Based on Home Video Coding at 12 Months

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2023 Full text Cite

Autism Caregiver Coaching in Africa (ACACIA): Protocol for a type 1-hybrid effectiveness-implementation trial.

Journal Article medRxiv · September 11, 2023 BACKGROUND: While early autism intervention can significantly improve outcomes, gaps in implementation exist globally. These gaps are clearest in Africa, where forty percent of the world's children will live by 2050. Task-sharing early intervention to non- ... Full text Link to item Cite

Could an Eye-Tracking Test Aid Clinicians in Making an Autism Diagnosis?: New Findings and a Look to the Future.

Journal Article JAMA · September 5, 2023 Full text Link to item Cite

Attention Allocation During Exploration of Visual Arrays in ASD: Results from the ABC-CT Feasibility Study.

Journal Article J Autism Dev Disord · August 2023 Visual exploration paradigms involving object arrays have been used to examine salience of social stimuli such as faces in ASD. Recent work suggests performance on these paradigms may associate with clinical features of ASD. We evaluate metrics from a visu ... Full text Link to item Cite

Enhancing early autism prediction based on electronic records using clinical narratives.

Journal Article J Biomed Inform · August 2023 Recent work has shown that predictive models can be applied to structured electronic health record (EHR) data to stratify autism likelihood from an early age (<1 year). Integrating clinical narratives (or notes) with structured data has been shown to impro ... Full text Link to item Cite

Relationship between quantitative digital behavioral features and clinical profiles in young autistic children.

Journal Article Autism Res · July 2023 Early behavioral markers for autism include differences in social attention and orienting in response to one's name when called, and differences in body movements and motor abilities. More efficient, scalable, objective, and reliable measures of these beha ... Full text Link to item Cite

Blink rate and facial orientation reveal distinctive patterns of attentional engagement in autistic toddlers: a digital phenotyping approach.

Journal Article Sci Rep · May 3, 2023 Differences in social attention are well-documented in autistic individuals, representing one of the earliest signs of autism. Spontaneous blink rate has been used to index attentional engagement, with lower blink rates reflecting increased engagement. We ... Full text Link to item Cite

Concomitant medication use in children with autism spectrum disorder: Data from the Autism Biomarkers Consortium for Clinical Trials.

Journal Article Autism · May 2023 Children with autism spectrum disorder are prescribed a variety of medications that affect the central nervous system (psychotropic medications) to address behavior and mood. In clinical trials, individuals taking concomitant psychotropic medications often ... Full text Link to item Cite

Eye-tracking measures of social versus nonsocial attention are related to level of social engagement during naturalistic caregiver-child interactions in autistic children.

Journal Article Autism Res · May 2023 Eye-tracking (ET) measures indexing social attention have been proposed as sensitive measures related to autism, but less is known about the relationship between social and nonsocial attention and naturalistic measures of social engagement and whether sex ... Full text Link to item Cite

Evaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials.

Journal Article Autism Res · May 2023 Clinical trials in autism spectrum disorder (ASD) often rely on clinician rating scales and parent surveys to measure autism-related features and social behaviors. To aid in the selection of these assessments for future clinical trials, the Autism Biomarke ... Full text Link to item Cite

A functional model for studying common trends across trial time in eye tracking experiments.

Journal Article Stat Biosci · April 2023 Eye tracking (ET) experiments commonly record the continuous trajectory of a subject's gaze on a two-dimensional screen throughout repeated presentations of stimuli (referred to as trials). Even though the continuous path of gaze is recorded during each tr ... Full text Link to item Cite

Prediction of autism in infants: progress and challenges.

Journal Article Lancet Neurol · March 2023 Autism spectrum disorder (henceforth autism) is a neurodevelopmental condition that can be reliably diagnosed in children by age 18-24 months. Prospective longitudinal studies of infants aged 1 year and younger who are later diagnosed with autism are eluci ... Full text Link to item Cite

A tablet-based game for the assessment of visual motor skills in autistic children.

Journal Article NPJ Digit Med · February 3, 2023 Increasing evidence suggests that early motor impairments are a common feature of autism. Thus, scalable, quantitative methods for measuring motor behavior in young autistic children are needed. This work presents an engaging and scalable assessment of vis ... Full text Open Access Link to item Cite

Predictive Value of Early Autism Detection Models Based on Electronic Health Record Data Collected Before Age 1 Year.

Journal Article JAMA Netw Open · February 1, 2023 IMPORTANCE: Autism detection early in childhood is critical to ensure that autistic children and their families have access to early behavioral support. Early correlates of autism documented in electronic health records (EHRs) during routine care could all ... Full text Link to item Cite

Exploring Complexity of Facial Dynamics in Autism Spectrum Disorder.

Journal Article IEEE Trans Affect Comput · 2023 Atypical facial expression is one of the early symptoms of autism spectrum disorder (ASD) characterized by reduced regularity and lack of coordination of facial movements. Automatic quantification of these behaviors can offer novel biomarkers for screening ... Full text Link to item Cite

Complexity analysis of head movements in autistic toddlers.

Journal Article J Child Psychol Psychiatry · January 2023 BACKGROUND: Early differences in sensorimotor functioning have been documented in young autistic children and infants who are later diagnosed with autism. Previous research has demonstrated that autistic toddlers exhibit more frequent head movement when vi ... Full text Link to item Cite

The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers.

Journal Article Am J Psychiatry · January 1, 2023 OBJECTIVE: Numerous candidate EEG biomarkers have been put forward for use in clinical research on autism spectrum disorder (ASD), but biomarker development has been hindered by limited attention to the psychometric properties of derived variables, inconsi ... Full text Link to item Cite

Constrained Multivariate Functional Principal Components Analysis for Novel Outcomes in Eye-Tracking Experiments

Journal Article Statistics in Biosciences · January 1, 2023 Individuals with autism spectrum disorder (ASD) tend to experience greater difficulties with social communication and sensory information processing. Of particular interest in ASD biomarker research is the study of visual attention, effectively quantified ... Full text Cite

Neurodiversity and Early Autism-Reply.

Journal Article JAMA Pediatr · December 1, 2022 Full text Link to item Cite

3.43 More Severe Executive Function Impairments Are Associated With Increases in Frontal Theta and Decreases in Beta and Gamma EEG Power in Young Children With ASD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2022 Full text Cite

3.40 Eye-Tracking Biomarkers of Social Attention Are Related to Naturalistic Social Interactions in Children With ASD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2022 Full text Cite

3.36 The Prevalence and Nature of Developmental Concerns Evident Prior to Receiving a Positive ASD Screening in Primary Care

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2022 Full text Cite

At a Crossroads-Reconsidering the Goals of Autism Early Behavioral Intervention From a Neurodiversity Perspective.

Journal Article JAMA Pediatr · September 1, 2022 Full text Link to item Cite

Multilevel hybrid principal components analysis for region-referenced functional electroencephalography data.

Journal Article Stat Med · August 30, 2022 Electroencephalography experiments produce region-referenced functional data representing brain signals in the time or the frequency domain collected across the scalp. The data typically also have a multilevel structure with high-dimensional observations c ... Full text Link to item Cite

Shorter average look durations to dynamic social stimuli are associated with higher levels of autism symptoms in young autistic children.

Journal Article Autism · August 2022 Many studies of autism look at the differences in how autistic research participants look at certain types of images. These studies often focus on where research participants are looking within the image, but that does not tell us everything about how much ... Full text Link to item Cite

The Early Start Denver Model Intervention and Mu Rhythm Attenuation in Autism Spectrum Disorders.

Journal Article J Autism Dev Disord · July 2022 We examined the relationship between the Early start Denver model (ESDM) intervention and mu rhythm attenuation, an EEG paradigm reflecting neural processes associated with action perception and social information processing. Children were assigned to eith ... Full text Link to item Cite

Patterns of Intervention Utilization Among School-Aged Children with Autism Spectrum Disorder: Findings from a Multi-Site Research Consortium.

Journal Article Res Autism Spectr Disord · June 2022 When designing and interpreting results from clinical trials evaluating treatments for children on the autism spectrum, a complicating factor is that most children receive a range of concurrent treatments. Thus, it is important to better understand the typ ... Full text Link to item Cite

Harnessing the Power of Artificial Intelligence in Otolaryngology and the Communication Sciences.

Journal Article J Assoc Res Otolaryngol · June 2022 Use of artificial intelligence (AI) is a burgeoning field in otolaryngology and the communication sciences. A virtual symposium on the topic was convened from Duke University on October 26, 2020, and was attended by more than 170 participants worldwide. Th ... Full text Link to item Cite

Higher Risk of Mortality for Individuals Diagnosed With Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder Demands a Public Health Prevention Strategy.

Journal Article JAMA Pediatr · April 1, 2022 Full text Link to item Cite

The autism biomarkers consortium for clinical trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials.

Journal Article Mol Autism · March 21, 2022 BACKGROUND: Eye tracking (ET) is a powerful methodology for studying attentional processes through quantification of eye movements. The precision, usability, and cost-effectiveness of ET render it a promising platform for developing biomarkers for use in c ... Full text Link to item Cite

Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Africa.

Journal Article Autism · January 2022 COVID-19 caused many autism spectrum disorder caregiver-coaching studies to move to telehealth. Telehealth can increase the diversity of people who take part in research. This matters because most autism spectrum disorder studies have included people who h ... Full text Link to item Cite

Identifying Age Based Maturation in the ERP Response to Faces in Children With Autism: Implications for Developing Biomarkers for Use in Clinical Trials.

Journal Article Front Psychiatry · 2022 Recent proposals have suggested the potential for neural biomarkers to improve clinical trial processes in neurodevelopmental conditions; however, few efforts have identified whether chronological age-based adjustments will be necessary (as used in standar ... Full text Link to item Cite

ASSOCIATIONS BETWEEN SLEEP PROBLEMS AND ADHD SYMPTOMS IN EARLY CHILDHOOD: A LONGITUDINAL, PRIMARY-CARE BASED STUDY

Conference SLEEP · 2022 Cite

Changes in the geometry and robustness of diffusion tensor imaging networks: Secondary analysis from a randomized controlled trial of young autistic children receiving an umbilical cord blood infusion.

Journal Article Front Psychiatry · 2022 Diffusion tensor imaging (DTI) has been used as an outcome measure in clinical trials for several psychiatric disorders but has rarely been explored in autism clinical trials. This is despite a large body of research suggesting altered white matter structu ... Full text Link to item Cite

Distance from Typical Scan Path When Viewing Complex Stimuli in Children with Autism Spectrum Disorder and its Association with Behavior.

Journal Article J Autism Dev Disord · October 2021 Eye-tracking is often used to study attention in children with autism spectrum disorder (ASD). Previous research has identified multiple atypical patterns of attention in children with ASD based on areas-of-interest analysis. Fewer studies have investigate ... Full text Open Access Link to item Cite

Patterns of Health Services Use Before Age 1 in Children Later Diagnosed With ADHD.

Journal Article J Atten Disord · October 2021 Background: Children with ADHD have 2 to 3 times increased health care utilization and annual costs once diagnosed, but little is known about utilization patterns early in life, prior to diagnosis. Quantifying early health services use among children later ... Full text Link to item Cite

A scalable computational approach to assessing response to name in toddlers with autism.

Journal Article J Child Psychol Psychiatry · September 2021 BACKGROUND: This study is part of a larger research program focused on developing objective, scalable tools for digital behavioral phenotyping. We evaluated whether a digital app delivered on a smartphone or tablet using computer vision analysis (CVA) can ... Full text Link to item Cite

Corrigendum to "Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions. [European Neuropsychopharmacology Volume 48, July 2021, Pages 3-31]".

Journal Article Eur Neuropsychopharmacol · September 2021 Full text Link to item Cite

Computational Methods to Measure Patterns of Gaze in Toddlers With Autism Spectrum Disorder.

Journal Article JAMA Pediatr · August 1, 2021 IMPORTANCE: Atypical eye gaze is an early-emerging symptom of autism spectrum disorder (ASD) and holds promise for autism screening. Current eye-tracking methods are expensive and require special equipment and calibration. There is a need for scalable, fea ... Full text Link to item Cite

Visual Preference for Biological Motion in Children and Adults with Autism Spectrum Disorder: An Eye-Tracking Study.

Journal Article J Autism Dev Disord · July 2021 Participants with autism spectrum disorder (ASD) (n = 121, mean [SD] age: 14.6 [8.0] years) and typically developing (TD) controls (n = 40, 16.4 [13.3] years) were presented with a series of videos representing biological motion on one side of a computer m ... Full text Link to item Cite

Assessment of outcomes in autism clinical trials over the course of development.

Journal Article Eur Neuropsychopharmacol · July 2021 Full text Link to item Cite

Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.

Journal Article Eur Neuropsychopharmacol · July 2021 In 2017, facing lack of progress and failures encountered in targeted drug development for Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM with the ECNP created the ASD Working Group charged to identify barriers to progre ... Full text Link to item Cite

A Multisite Randomized Controlled Trial Comparing the Effects of Intervention Intensity and Intervention Style on Outcomes for Young Children With Autism.

Journal Article J Am Acad Child Adolesc Psychiatry · June 2021 OBJECTIVE: This randomized, multisite, intent-to-treat study tested the effects of 2 levels of treatment intensity (number of hours) and 2 treatment styles on the progress of young children with autism spectrum disorder (ASD). We predicted that initial sev ... Full text Link to item Cite

Promoting social communication in young children with ASD

Chapter · June 2021 "The new edition of this practical accessible text introduces preservice SLPs to 12 evidence-based interventions that improve the communication and social skills of people with autism spectrum disorder"-- ... Cite

Digital Behavioral Phenotyping Detects Atypical Pattern of Facial Expression in Toddlers with Autism.

Journal Article Autism Res · March 2021 Commonly used screening tools for autism spectrum disorder (ASD) generally rely on subjective caregiver questionnaires. While behavioral observation is more objective, it is also expensive, time-consuming, and requires significant expertise to perform. As ... Full text Link to item Cite

Reply.

Journal Article J Pediatr · March 2021 Full text Link to item Cite

Gastrointestinal problems are associated with increased repetitive behaviors but not social communication difficulties in young children with autism spectrum disorders.

Journal Article Autism · February 2021 Individuals with autism spectrum disorder are more likely than typically developing individuals to experience a range of gastrointestinal abnormalities, including chronic diarrhea, constipation, food sensitivities, and abdominal pain. These gastrointestina ... Full text Link to item Cite

Computer Vision Analysis for Quantification of Autism Risk Behaviors.

Journal Article IEEE Trans Affect Comput · 2021 Observational behavior analysis plays a key role for the discovery and evaluation of risk markers for many neurodevelopmental disorders. Research on autism spectrum disorder (ASD) suggests that behavioral risk markers can be observed at 12 months of age or ... Full text Link to item Cite

A Scalable Off-the-Shelf Framework for Measuring Patterns of Attention in Young Children and its Application in Autism Spectrum Disorder.

Journal Article IEEE Trans Affect Comput · 2021 Autism spectrum disorder (ASD) is associated with deficits in the processing of social information and difficulties in social interaction, and individuals with ASD exhibit atypical attention and gaze. Traditionally, gaze studies have relied upon precise an ... Full text Link to item Cite

PROJECTING THE LONG-TERM CLINICAL AND ECONOMIC IMPACT OF AUTOLOGOUS CORD BLOOD INFUSION IN CHILDREN WITH AUTISM

Conference MEDICAL DECISION MAKING · 2021 Cite

Sleep Problems and Trajectories of Restricted and Repetitive Behaviors in Children with Neurodevelopmental Disabilities.

Journal Article J Autism Dev Disord · November 2020 Sleep problems are prevalent in children with neurodevelopmental disabilities and are associated with the expression of restricted and repetitive behaviors (RRBs). Children (n = 57) with autism spectrum disorder (ASD, n = 38) or developmental delay (DD, n ... Full text Link to item Cite

Health system utilization before age 1 among children later diagnosed with autism or ADHD.

Journal Article Sci Rep · October 19, 2020 Children with autism spectrum disorder (ASD) or attention deficit hyperactivity disorder (ADHD) have 2-3 times increased healthcare utilization and annual costs once diagnosed, but little is known about their utilization patterns early in life. Quantifying ... Full text Link to item Cite

Social attention to activities in children and adults with autism spectrum disorder: effects of context and age.

Journal Article Mol Autism · October 19, 2020 BACKGROUND: Diminished visual monitoring of faces and activities of others is an early feature of autism spectrum disorder (ASD). It is uncertain whether deficits in activity monitoring, identified using a homogeneous set of stimuli, persist throughout the ... Full text Link to item Cite

Impact of a digital Modified Checklist for Autism in Toddlers-Revised on likelihood and age of autism diagnosis and referral for developmental evaluation.

Journal Article Autism · October 2020 This was a project in primary care for young children (1-2 years old). We tested a parent questionnaire on a tablet. This tablet questionnaire asked questions to see whether the child may have autism. We compared the paper and pencil version of the questio ... Full text Link to item Cite

Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder.

Journal Article Stem Cells Transl Med · October 2020 Ongoing neuroinflammation may contribute to symptoms of autism spectrum disorder (ASD) in at least a portion of affected individuals. Mesenchymal stromal cells (MSCs) have demonstrated the capacity to modulate neuroinflammation, but safety and feasibility ... Full text Open Access Link to item Cite

BUILDING PROGRAMS THAT INCREASE ACCESS TO MENTAL HEALTH CARE FOR CHILDREN AND YOUTH, WHILE EXPANDING THE EVIDENCE BASE TO ENHANCE ACCESS AND IMPROVE DIAGNOSIS AND TREATMENT

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2020 Full text Cite

An Investigation of a Classroom-Based Specialized Music Therapy Model for Children With Autism Spectrum Disorder: Voices Together Using the VOICSS^™ Method

Journal Article Focus on Autism and Other Developmental Disabilities · September 1, 2020 Students with autism spectrum disorder (ASD) have marked deficits in social communication skills, which can challenge their ability to participate in academic and social activities. Music therapy is a popular intervention for children with ASD, and althoug ... Full text Cite

A Six-Minute Measure of Vocalizations in Toddlers with Autism Spectrum Disorder.

Journal Article Autism Res · August 2020 To improve early identification of autism spectrum disorder (ASD), we need objective, reliable, and accessible measures. To that end, a previous study demonstrated that a tablet-based application (app) that assessed several autism risk behaviors distinguis ... Full text Open Access Link to item Cite

Infant EEG theta modulation predicts childhood intelligence.

Journal Article Sci Rep · July 8, 2020 Intellectual functioning is a critical determinant of economic and personal productivity. Identifying early neural predictors of cognitive function in infancy will allow us to map the neurodevelopmental pathways that underpin individual differences in inte ... Full text Link to item Cite

Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.

Journal Article Sci Rep · July 2, 2020 Ollivier-Ricci curvature is a method for measuring the robustness of connections in a network. In this work, we use curvature to measure changes in robustness of brain networks in children with autism spectrum disorder (ASD). In an open label clinical tria ... Full text Open Access Link to item Cite

The influence of background auditory noise on P50 and N100 suppression elicited by the paired-click paradigm

Journal Article Journal of Psychophysiology · July 1, 2020 Auditory sensory gating is commonly assessed using the Paired-Click Paradigm (PCP), an electroencephalography (EEG) task in which two identical sounds are presented sequentially and the brain's inhibitory response to the second sound is measured. Many clin ... Full text Cite

Social impairments in alternating hemiplegia of childhood.

Journal Article Dev Med Child Neurol · July 2020 AIM: To evaluate presence and severity of social impairments in alternating hemiplegia of childhood (AHC) and determine factors that are associated with social impairments. METHOD: This was a retrospective analysis of 34 consecutive patients with AHC (19 f ... Full text Link to item Cite

Duane F. Alexander, M.D.: August 11, 1940-February 16, 2020.

Journal Article J Autism Dev Disord · July 2020 Full text Link to item Cite

A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder.

Journal Article J Pediatr · July 2020 OBJECTIVE: To evaluate whether umbilical cord blood (CB) infusion is safe and associated with improved social and communication abilities in children with autism spectrum disorder (ASD). STUDY DESIGN: This prospective, randomized, placebo-controlled, doubl ... Full text Open Access Link to item Cite

The Early Start Denver Model (ESDM)

Chapter · June 23, 2020 Topics featured in this book include: Autism screening tools and interdisciplinary coordination of the processes. Dell Children’s (S)TAAR Model of Early Autism Assessment. The Early Start Denver Model (ESDM). ... Cite

Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder.

Journal Article J Autism Dev Disord · June 2020 There is a need for measures to track symptom change in autism spectrum disorder (ASD). We conducted a validation study on a revised version of the Autism Behavior Inventory (ABI), and a short form (ABI-S). Caregivers of individuals (6-54 years) with confi ... Full text Link to item Cite

Publisher Correction: ASPI: a public-private partnership to develop treatments for autism.

Journal Article Nat Rev Drug Discov · June 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability.

Journal Article Mol Autism · May 11, 2020 BACKGROUND: Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent of this discrepancy is limited and inconsistent. Use of automated facial expression detection techn ... Full text Link to item Cite

ASPI: a public-private partnership to develop treatments for autism.

Journal Article Nat Rev Drug Discov · April 2020 Full text Link to item Cite

Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Journal Article Neurology · March 3, 2020 OBJECTIVE: To review pharmacologic and nonpharmacologic strategies for treating sleep disturbances in children and adolescents with autism spectrum disorder (ASD) and to develop recommendations for addressing sleep disturbance in this population. METHODS: ... Full text Link to item Cite

Relative Average Look Duration and its Association with Neurophysiological Activity in Young Children with Autism Spectrum Disorder.

Journal Article Sci Rep · February 5, 2020 Autism Spectrum Disorder (ASD) is characterized by early attentional differences that often precede the hallmark symptoms of social communication impairments. Development of novel measures of attentional behaviors may lead to earlier identification of chil ... Full text Link to item Cite

Author Correction: Atypical postural control can be detected via computer vision analysis in toddlers with autism spectrum disorder.

Journal Article Sci Rep · January 14, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Link to item Cite

Relationship Between Sleep and Behavior in Autism Spectrum Disorder: Exploring the Impact of Sleep Variability.

Journal Article Front Neurosci · 2020 OBJECTIVE: The relationship between sleep (caregiver-reported and actigraphy-measured) and other caregiver-reported behaviors in children and adults with autism spectrum disorder (ASD) was examined, including the use of machine learning to identify sleep v ... Full text Link to item Cite

The Autism Biomarkers Consortium for Clinical Trials (ABC-CT): Scientific Context, Study Design, and Progress Toward Biomarker Qualification.

Journal Article Front Integr Neurosci · 2020 Clinical research in neurodevelopmental disorders remains reliant upon clinician and caregiver measures. Limitations of these approaches indicate a need for objective, quantitative, and reliable biomarkers to advance clinical research. Extant research sugg ... Full text Link to item Cite

Day-to-Day Test-Retest Reliability of EEG Profiles in Children With Autism Spectrum Disorder and Typical Development.

Journal Article Front Integr Neurosci · 2020 Biomarker development is currently a high priority in neurodevelopmental disorder research. For many types of biomarkers (particularly biomarkers of diagnosis), reliability over short periods is critically important. In the field of autism spectrum disorde ... Full text Link to item Cite

The early start denver model (ESDM)

Chapter · January 1, 2020 The Early Start DenverModel (ESDM; Rogers and Dawson in The Early Start Denver Model for Young Children with Autism: Promoting Language, Learning, and Engagement. Guilford Press, New York, 2010) is an evidence-based early intervention designed to promote d ... Full text Cite

1.14 GRAPH CURVATURE AS A METHOD FOR DISCERNING ROBUSTNESS IN BRAIN NETWORKS IN ASD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2019 Full text Cite

RELATIONSHIP BETWEEN SENSORY PROCESSING DIFFERENCES AND CLINICAL FEATURES OF CHILDREN WITH ASD

Conference JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY · October 1, 2019 Full text Link to item Cite

A Multisite Randomized Controlled Two-Phase Trial of the Early Start Denver Model Compared to Treatment as Usual.

Journal Article J Am Acad Child Adolesc Psychiatry · September 2019 OBJECTIVE: This single-blind, randomized, multisite, intent-to-treat study was designed to replicate and extend Dawson et al.'s (Pediatrics. 2010;125: e17-e23) randomized controlled trial testing the effects of the Early Start Denver Model (ESDM), an inten ... Full text Link to item Cite

Methodological considerations in the use of Noldus EthoVision XT video tracking of children with autism in multi-site studies.

Journal Article Biol Psychol · September 2019 Animal models of autism spectrum disorders (ASD) contribute to understanding of the role of genetics and the biological mechanisms underlying behavioral phenotypes and inform the development of potential treatments. Translational biomarkers are needed that ... Full text Link to item Cite

EEG AND PUPILLARY RESPONSE IN CHILDREN WITH AUTISM: RESULTS FROM THE AUTISM BIOMARKERS CONSORTIUM FOR CLINICAL TRIALS INTERIM ANALYSIS

Conference PSYCHOPHYSIOLOGY · September 1, 2019 Link to item Cite

A novel method for measuring learning opportunities provided by parents to young children with autism spectrum disorder.

Journal Article Autism · August 2019 The aim of this study was to develop a measurement approach to assess the learning opportunities provided by parents to their young children with autism spectrum disorder during a free play task and to examine the relationship between learning opportunitie ... Full text Link to item Cite

Implementing early intervention for autism spectrum disorder: a global perspective.

Journal Article Pediatr Med · August 2019 Full text Open Access Link to item Cite

Sensory Over-Responsivity: An Early Risk Factor for Anxiety and Behavioral Challenges in Young Children.

Journal Article J Abnorm Child Psychol · June 2019 Anxiety disorders are prevalent and significantly impact young children and their families. One hypothesized risk factor for anxiety is heightened responses to sensory input. Few studies have explored this hypothesis prospectively. This study had two goals ... Full text Link to item Cite

Increasing global access to early intervention for young children with ASD

Journal Article Pediatric Medicine · June 1, 2019 Full text Cite

Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors.

Journal Article Autism Res · May 2019 Full text Link to item Cite

Meeting the demands of msc production for clinical studies

Conference Cytotherapy · May 2019 Full text Cite

Computer vision analysis captures atypical attention in toddlers with autism.

Journal Article Autism · April 2019 To demonstrate the capability of computer vision analysis to detect atypical orienting and attention behaviors in toddlers with autism spectrum disorder. One hundered and four toddlers of 16-31 months old (mean = 22) participated in this study. Twenty-two ... Full text Link to item Cite

Brief Report: Pilot Study of a Novel Interactive Digital Treatment to Improve Cognitive Control in Children with Autism Spectrum Disorder and Co-occurring ADHD Symptoms.

Journal Article J Autism Dev Disord · April 2019 The presence of attention deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorder (ASD) is associated with worse cognitive control. Children with ASD and ADHD often respond poorly to medications, thus we need alternative tr ... Full text Link to item Cite

Potential for Digital Behavioral Measurement Tools to Transform the Detection and Diagnosis of Autism Spectrum Disorder.

Journal Article JAMA Pediatr · April 1, 2019 Full text Link to item Cite

Inappropriate Use of the Term Autism as Analogy.

Journal Article JAMA Pediatr · April 1, 2019 Full text Link to item Cite

On Target Shift in Adversarial Domain Adaptation.

Journal Article Proc Mach Learn Res · April 2019 Discrepancy between training and testing domains is a fundamental problem in the generalization of machine learning techniques. Recently, several approaches have been proposed to learn domain invariant feature representations through adversarial deep learn ... Link to item Cite

Caregiver Daily Reporting of Symptoms in Autism Spectrum Disorder: Observational Study Using Web and Mobile Apps.

Journal Article JMIR Ment Health · March 26, 2019 BACKGROUND: Currently, no medications are approved to treat core symptoms of autism spectrum disorder (ASD). One barrier to ASD medication development is the lack of validated outcome measures able to detect symptom change. Current ASD interventions are of ... Full text Link to item Cite

Computer vision and behavioral phenotyping: an autism case study.

Journal Article Curr Opin Biomed Eng · March 2019 Despite significant recent advances in molecular genetics and neuroscience, behavioral ratings based on clinical observations are still the gold standard for screening, diagnosing, and assessing outcomes in neurodevelopmental disorders, including autism sp ... Full text Link to item Cite

Enhancing Low-Intensity Coaching in Parent Implemented Early Start Denver Model Intervention for Early Autism: A Randomized Comparison Treatment Trial.

Journal Article J Autism Dev Disord · February 2019 Short-term low intensity parent implemented intervention studies for toddlers with autism spectrum disorder (ASD) have found it difficult to demonstrate significantly improved developmental scores or autism severity compared to community treatment. We cond ... Full text Link to item Cite

White Matter Tract Changes Associated with Clinical Improvement in an Open-Label Trial Assessing Autologous Umbilical Cord Blood for Treatment of Young Children with Autism.

Journal Article Stem Cells Transl Med · February 2019 Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by social communication deficits and the presence of restricted interests and repetitive behaviors. We have previously reported significant improvements in behavior ... Full text Open Access Link to item Cite

Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder.

Journal Article J Autism Dev Disord · January 2019 Facial expression is impaired in autism spectrum disorder (ASD), but rarely systematically studied. We focus on the ability of individuals with ASD to produce facial expressions of emotions in response to a verbal prompt. We used the Janssen Autism Knowled ... Full text Link to item Cite

An Observational Study With the Janssen Autism Knowledge Engine (JAKE®) in Individuals With Autism Spectrum Disorder.

Journal Article Front Neurosci · 2019 Objective: The Janssen Autism Knowledge Engine (JAKE®) is a clinical research outcomes assessment system developed to more sensitively measure treatment outcomes and identify subpopulations in autism spectrum disorder (ASD). Here we describe JAKE and prese ... Full text Link to item Cite

On Target Shift in Adversarial Domain Adaptation

Conference International Conference on Artificial Intelligence and Statistics · 2019 Cite

Biomarker Acquisition and Quality Control for Multi-Site Studies: The Autism Biomarkers Consortium for Clinical Trials.

Journal Article Front Integr Neurosci · 2019 The objective of the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) is to evaluate a set of lab-based behavioral video tracking (VT), electroencephalography (EEG), and eye tracking (ET) measures for use in clinical trials with children with auti ... Full text Link to item Cite

Extracting Relationships by Multi-Domain Matching.

Journal Article Adv Neural Inf Process Syst · December 2018 In many biological and medical contexts, we construct a large labeled corpus by aggregating many sources to use in target prediction tasks. Unfortunately, many of the sources may be irrelevant to our target task, so ignoring the structure of the dataset is ... Link to item Cite

Atypical postural control can be detected via computer vision analysis in toddlers with autism spectrum disorder.

Journal Article Sci Rep · November 19, 2018 Evidence suggests that differences in motor function are an early feature of autism spectrum disorder (ASD). One aspect of motor ability that develops during childhood is postural control, reflected in the ability to maintain a steady head and body positio ... Full text Link to item Cite

Brief Report: A Survey of Autism Research Priorities Across a Diverse Community of Stakeholders.

Journal Article J Autism Dev Disord · November 2018 Inclusion of stakeholder voices in the allocation of research funding can increase the relevance of results and improve community engagement in research. We describe the results of an online survey that gathered input from community stakeholders regarding ... Full text Link to item Cite

Electrophysiological Biomarkers Predict Clinical Improvement in an Open-Label Trial Assessing Efficacy of Autologous Umbilical Cord Blood for Treatment of Autism.

Journal Article Stem Cells Transl Med · November 2018 This study was a phase I, single-center, and open-label trial of a single intravenous infusion of autologous umbilical cord blood in young children with autism spectrum disorder (ASD). Twenty-five children between the ages of 2 and 6 with a confirmed diagn ... Full text Open Access Link to item Cite

Visual Exploration in Autism Spectrum Disorder: Exploring Age Differences and Dynamic Features Using Recurrence Quantification Analysis.

Journal Article Autism Res · November 2018 Eye-tracking studies have demonstrated that individuals with autism spectrum disorder sometimes show differences in attention and gaze patterns. This includes preference for certain nonsocial objects, heightened attention to detail, and more difficulty wit ... Full text Link to item Cite

23.1 Autism and Beyond: Lessons From an Iphone Study of Young Children

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2018 Full text Cite

1.31 The Utility of Electroencephalogram (EEG) Beta Power as a Moderator of Treatment Response in ASD Clinical Trials Involving Young Children

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2018 Full text Cite

5.18 A Scalable Off-the-Shelf Framework for Measuring Children’s Direction of Attention in ASD

Conference Journal of the American Academy of Child & Adolescent Psychiatry · October 2018 Full text Cite

Caregiver Daily Reporting of Symptoms in Autism Spectrum Disorder: Observational Study Using Web and Mobile Apps (Preprint)

Journal Article · June 28, 2018 BACKGROUNDCurrently, no medications are approved to treat core symptoms of autism spectrum disorder (ASD). One barrier to ASD medication development is the lack of validated outcome measu ... Full text Cite

Analysis of shared heritability in common disorders of the brain.

Journal Article Science · June 22, 2018 Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 pa ... Full text Link to item Cite

Manufacturing of allogeneic human cord tissue mesenchymal stromal cells: Initial results of a phase I clinical trial in children with autism spectrum disorder

Conference Cytotherapy · May 2018 Full text Cite

Sensory hypersensitivity predicts enhanced attention capture by faces in the early development of ASD.

Journal Article Dev Cogn Neurosci · January 2018 Sensory sensitivity is prevalent among young children with ASD, but its relation to social communication impairment is unclear. Recently, increased sensory hypersensitivity has been linked to greater activity of the neural salience network (Green et al., 2 ... Full text Link to item Cite

Brief Report: Executive Function as a Predictor of Academic Achievement in School-Aged Children with ASD.

Journal Article J Autism Dev Disord · January 2018 The contributions of Executive Function (EF) to academic achievement in children with Autism Spectrum Disorder (ASD) are not well understood. Academic achievement and its association with EF is described in 32, 9-year-old children with ASD. EF at age 6 and ... Full text Link to item Cite

Validation of eye-tracking measures of social attention as a potential biomarker for autism clinical trials.

Journal Article Autism Res · January 2018 UNLABELLED: Social communication impairments are a core feature of autism spectrum disorder (ASD), and this class of symptoms is a target for treatments for the disorder. Measures of social attention, assessed via eye-gaze tracking (EGT), have been propose ... Full text Link to item Cite

Automatic emotion and attention analysis of young children at home: a ResearchKit autism feasibility study.

Journal Article NPJ Digit Med · 2018 Current tools for objectively measuring young children's observed behaviors are expensive, time-consuming, and require extensive training and professional administration. The lack of scalable, reliable, and validated tools impacts access to evidence-based ... Full text Open Access Link to item Cite

Extracting relationships by multi-domain matching

Conference Advances in Neural Information Processing Systems · 2018 Cite

Autism Behavior Inventory: A Novel Tool for Assessing Core and Associated Symptoms of Autism Spectrum Disorder.

Journal Article J Child Adolesc Psychopharmacol · November 2017 OBJECTIVE: Autism Behavior Inventory (ABI) is a new measure for assessing changes in core and associated symptoms of autism spectrum disorder (ASD) in participants (ages: 3 years-adulthood) diagnosed with ASD. It is a web-based tool with five domains (two ... Full text Link to item Cite

Phase I Open Label Trial of Autologous Cord Blood for Treatment of Autism: Correlations Between Behavioral Improvement and Increased White Matter Connectivity in Children With Autism

Conference NEUROPSYCHOPHARMACOLOGY · November 1, 2017 Link to item Cite