Heberto Suarez Roca

Conference The journal of pain · January 2024 Excessive postoperative pain can lead to extended hospitalization and increased expenses, but factors that predict its severity are still unclear. Baroreceptor function could influence postoperative pain by modulating nociceptive processing and vagal-media ... Full text Cite

Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.

Conference J Pain · January 2024 Excessive postoperative pain can lead to extended hospitalization and increased expenses, but factors that predict its severity are still unclear. Baroreceptor function could influence postoperative pain by modulating nociceptive processing and vagal-media ... Full text Link to item Cite

Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.

Journal Article Compr Physiol · February 12, 2021 Baroreceptors are mechanosensitive elements of the peripheral nervous system that maintain cardiovascular homeostasis by coordinating the responses to external and internal environmental stressors. While it is well known that carotid and cardiopulmonary ba ... Full text Link to item Cite

Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.

Journal Article Anesthesiology · April 2019 Featured Publication Baroreceptors are mechanosensitive elements of the peripheral nervous system that maintain homeostasis by coordinating physiologic responses to external and internal stimuli. While it is recognized that carotid and cardiopulmonary baroreceptor reflexes mod ... Full text Link to item Cite

Addicted to Compulsions: A Complex Case Study of Obsessive and Compulsive Disorder Treated with Acceptance and Commitment Therapy (ACT) and Exposure Therapy (ERP)

Journal Article Drug Dependence and Addiction - Open Access Journal · January 21, 2019 Full text Open Access Cite

Psychological intervention based on psychoneuroimmunology improves clinical evolution, quality of life, and immunity of children with leukemia: A preliminary study.

Journal Article Health psychology open · January 2019 We conducted a non-randomized, open-label clinical trial to assess whether a psychoneuroimmunology-based intervention enhanced immunity in children with acute lymphoblastic leukemia undergoing chemotherapy. In total, 16 children (44% female) received psych ... Full text Cite

Impact of two therapeutic interventions in patients with non-specific low back pain

Journal Article Salud Uninorte · May 1, 2018 Objective: To evaluate the impact of two therapeutic interventions in patients with non-specific low back pain. Materials and methods: Prospective study, in which in 20 subjects from both genders assigned through consecutive sampling of the two interventio ... Full text Cite

Magnesium sulfate prevents the development of forced swim induced hyperalgesia in rats

Journal Article Investigacion Clinica (Venezuela) · January 1, 2018 The present study evaluated the effect of magnesium sulfate (MgSO4) on forced swim-induced thermal hyperalgesia in male Sprague-Dawley rats. Two schemes of MgSO4 administration were used: a preemptive scheme (100 mg/kg i.p. before each forced swim) and a t ... Full text Cite

[Novel central dopaminergic agents derived from atypical di-substituted 2-aminoindane-4, 7. Synthesis and central pharmacological profile].

Journal Article Investigacion clinica · June 2015 In recent decades, many compounds with central dopaminergic activity have been designed, synthesized and evaluated pharmacologically. However, it has not been possible to obtain a drug able to improve or cure diseases involving dopaminergic regulation in t ... Cite

Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.

Journal Article Neuroscience letters · March 2015 Featured Publication We evaluated the association between spinal PGE2 and thermal hyperalgesia following repeated stress. Thermal nociception was determined in male Sprague-Dawley rats using the hot-plate test, before and after forced-swimming; non-conditioned rats served as c ... Full text Cite

Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia.

Journal Article Brain research bulletin · January 2014 Featured Publication Although it is widely known that immunological, hormonal and nociceptive mechanisms are altered by exposure to repeated stress, the interplaying roles of each function in the development of post-stress hyperalgesia are not completely clear. Thus, we wanted ... Full text Cite

Synthesis and preliminary pharmacological evaluation of methoxilated indoles with possible dopaminergic central action

Journal Article Latin American Journal of Pharmacy · December 1, 2011 Compounds 5-7 were synthesized from 4-tetralones with o-iodoanilines by a radical nucleophilic substitution or SRN1 reaction, and were pharmacologically evaluated in order to establish their possible antagonistic action on the central dopaminergic receptor ... Cite

Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.

Journal Article Pain · August 2011 Featured Publication GABA and glutamate are both affected by stress and are involved in nociception. Thus, we determined whether stress-induced enhancement of inflammatory hyperalgesia is mediated by an imbalance between glutamate and GABA neurotransmission. Male rats were sub ... Full text Cite

Enhanced central thermal nociception in mildly depressed nonpatients and transiently sad healthy subjects.

Journal Article The journal of pain · March 2011 Featured Publication UnlabelledEvidence of support for sensory changes during minor depression and sadness is scarce and the neural mechanisms are unclear. We assessed central pain processing engaged in nociceptive C-fiber polymodal activity by examining the perceptio ... Full text Cite

[Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism].

Journal Article Investigacion clinica · September 2009 Some cases of autism could be linked to viral infections able to induce autoimmune mechanisms directed against the encephalon. Neurothophic virus infections in animals are associated with clinical signs that are similar to those observed in neurodevelopmen ... Cite

Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib.

Journal Article Brain research bulletin · August 2009 Non-steroidal anti-inflammatory drugs (NSAIDs) are thought to exert their pharmacological actions by a common mechanism: inhibition of cyclooxygenase (COX)-mediated prostanoid synthesis. Yet, differences and dissociation between their analgesic and anti-in ... Full text Cite

Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.

Journal Article Behavioural brain research · May 2008 Featured Publication We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect ... Full text Cite

Analgesic efficacy of milnacipran in animal models of chronic pain

Conference BIOLOGICAL PSYCHIATRY · April 1, 2008 Link to item Cite

Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans.

Journal Article Bioorganic & medicinal chemistry · March 2008 Brain dopaminergic system has a crucial role in the etiology of several neuropsychiatric disorders, including Parkinson's disease, depression, and schizophrenia. Several dopaminergic drugs are used to treat these pathologies, but many problems are attribut ... Full text Cite

[The Zung's autoscale for depression as predictor of sensorial and autonomic alterations to pain].

Journal Article Investigacion clinica · December 2007 Clinical and experimental evidence support a relationship between susceptibility to chronic pain and a subjacent depression. Nevertheless, it's not clear if the currently available clinical evaluation instruments for depression allow for linking both disor ... Cite

Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.

Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.

Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.

Addicted to Compulsions: A Complex Case Study of Obsessive and Compulsive Disorder Treated with Acceptance and Commitment Therapy (ACT) and Exposure Therapy (ERP)

Journal Article Drug Dependence and Addiction - Open Access Journal · January 21, 2019 Full text Open Access Cite

Psychological intervention based on psychoneuroimmunology improves clinical evolution, quality of life, and immunity of children with leukemia: A preliminary study.

Impact of two therapeutic interventions in patients with non-specific low back pain

Magnesium sulfate prevents the development of forced swim induced hyperalgesia in rats

[Novel central dopaminergic agents derived from atypical di-substituted 2-aminoindane-4, 7. Synthesis and central pharmacological profile].

Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.

Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia.

Synthesis and preliminary pharmacological evaluation of methoxilated indoles with possible dopaminergic central action

Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.

Enhanced central thermal nociception in mildly depressed nonpatients and transiently sad healthy subjects.

[Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism].

Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib.

Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.

Analgesic efficacy of milnacipran in animal models of chronic pain

Conference BIOLOGICAL PSYCHIATRY · April 1, 2008 Link to item Cite

Synthesis, dopaminergic profile, and molecular dynamics calculations of N-aralkyl substituted 2-aminoindans.

[The Zung's autoscale for depression as predictor of sensorial and autonomic alterations to pain].

Antinociceptive activity of Syzygium jambos leaves extract on rats.

Journal Article Journal of ethnopharmacology · June 2007 Syzygium jambos (L.) Alston (Myrtaceae) (syn Eugenia jambos) is a widespread medicinal plant traditionally used in sub-Saharan Africa to treat several diseases. The analgesic potential of leaf hydro-alcoholic extracts was assessed in rats. Hot plate and fo ... Full text Cite

Stress-induced muscle and cutaneous hyperalgesia: differential effect of milnacipran.

Journal Article Physiology & behavior · June 2006 We previously demonstrated that repeated swim stress produces long-term cutaneous hyperalgesia in rats. We have now determined the effect of stress upon muscle nociception and the anti-nociceptive efficacy of the norepinephrine-serotonin reuptake inhibitor ... Full text Cite

Role of mu-opioid and NMDA receptors in the development and maintenance of repeated swim stress-induced thermal hyperalgesia.

Journal Article Behavioural brain research · February 2006 Repeated exposure to swimming stress induces a long-lasting hyperalgesia in the rat by mechanisms to be elucidated. Since opioid and glutamate neurotransmitter systems modulate pain, we now evaluated the effect of pharmacological blockade of opioid and glu ... Full text Cite

Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals.

Journal Article Investigacion clinica · December 2004 Lantana trifolia L. (Verbenaceae) is traditionally used as an anti-inflammatory medicinal plant in Venezuela. The methanol extract of the aerial parts of L. trifolia were assessed for the anti-inflammatory, anti-nociceptive and anti-pyretic properties. The ... Cite

Conformational theoretical study of substituted and non-substituted N-aralkyl-2-aminoindans and its relation with dopaminergic activity

Journal Article Journal of Molecular Structure: THEOCHEM · September 30, 2003 Ab initio molecular orbital calculations are presented for two isomers of nine derivatives from 2-aminoindan. The study is centered in the geometrical analysis of the structures with adequate conformation to interact with the dopaminergic receptor. Pharmac ... Full text Cite

Increased perception of post-ischemic paresthesias in depressed subjects.

Journal Article Journal of psychosomatic research · September 2003 A psychophysical assessment of sensory activity linked to unmyelinated and myelinated primary afferents was conducted by estimating the intensity of thermal and tactile post-ischemic paresthesias in 11 nontreated depressed subjects (Zung's index > or =50) ... Full text Cite

Repeated swim stress increases pain-induced expression of c-Fos in the rat lumbar cord.

Journal Article Brain research · March 2003 We have previously demonstrated that repeated swim stress produces a long-lasting cutaneous hyperalgesia in rats. We have now looked at c-Fos expression in the spinal lumbar cord of male Sprague-Dawley rats subjected to 10-20 min daily sessions of forced s ... Full text Cite

The selective serotonin reuptake inhibitor citalopram induces the storage of serotonin in catecholaminergic terminals.

Journal Article The Journal of pharmacology and experimental therapeutics · July 2002 We investigated whether selective inhibition of serotonin (5-hydroxytryptamine; 5-HT) transporter with citalopram leads to accumulation of 5-HT in catecholaminergic neurons. In the rabbit olfactory tubercle, citalopram (1-10 microM) inhibited [(3)H]5-HT up ... Full text Cite

Substance P and calcitonin gene-related peptide increase IL-1 beta, IL-6 and TNF alpha secretion from human peripheral blood mononuclear cells.

Journal Article Neurochemistry international · April 2002 We found that substance P (SP) and calcitonin gene-related peptide (CGRP) (0.3-1 microM) increased, in a concentration-dependent manner, the basal secretion of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF alpha ... Full text Cite

Long-lasting delayed hyperalgesia after subchronic swim stress.

Journal Article Pharmacology, biochemistry, and behavior · November 2000 Rats subjected to an inescapable subchronic stress, consisting of 10-20 min of forced swimming for 3 days, showed a thermal hyperalgesia and an enhanced nociceptive behavior to the subcutaneous administration of formalin 24 and 48 h, respectively, after th ... Full text Cite

Chemical composition and biological activity of extracts from arrabidaea bilabiata.

Journal Article Pharmaceutical biology · January 2000 Consumption of Arrabidaea bilabiata fresh leaves produces a paraplegic syndrome in cattle. For isolation of the active principle, isopropanol and methanol extracts were prepared from the aerial parts of the plant; these were administered to Sprague-Dawley ... Full text Cite

Reduced tolerance and cardiovascular response to ischemic pain in minor depression.

Journal Article Journal of affective disorders · December 1999 BackgroundA paradoxical association between a higher prevalence of clinical pain and a reduced sensitivity to brief experimental pain seems to exist during depression.MethodsWe assessed the responses to sustained ischemic pain produced by ... Full text Cite

Opposite modulation of capsaicin-evoked substance P release by glutamate receptors.

Journal Article Neurochemistry international · December 1999 Substance P and glutamate are present in primary afferent C-fibers and play important roles in persistent inflammatory and neuropathic pain. In the present study, we have examined whether activation of different glutamate receptor subtypes modulates the re ... Full text Cite

Multiphasic morphine modulation of substance P release from capsaicin-sensitive primary afferent fibers.

Journal Article Neurochemical research · October 1999 Morphine produces a multiphasic modulation of K+-evoked substance P release from trigeminal slices and dorsal root ganglion neurons in culture. We now found that the C-fiber stimulant, capsaicin (1 microM), evoked release of substance P that was inhibited, ... Full text Cite

Dynorphin A increases substance P release from trigeminal primary afferent C-fibers.

Journal Article European journal of pharmacology · January 1999 Dynorphin A-(1-17) has been found to produce spinal antianalgesia and allodynia. Thus, we studied whether dynorphin A-(1-17) modulates substance P release evoked by the C-fiber-selective stimulant capsaicin (1 microM) from trigeminal nucleus caudalis slice ... Full text Cite

Opposite opioid modulation of substance P-containing primary afferents

Conference NEW ADVANCES IN CARDIOVASCULAR PHYSIOLOGY AND PHARMACOLOGY · January 1, 1998 Link to item Cite

Opposite opioid modulation of SP-containing primary afferents

Chapter · 1998 Cite

Motor activity and quantitative autoradiographic analysis of muscarinic receptors in the brain of rats subjected to the forced swimming test.

Journal Article Brain research bulletin · January 1997 A cholinergic dysfunction has been involved in the neurobiological mechanisms of stress and depression. In the present study, we determined the autoradiographic distribution of muscarinic cholinergic receptors in the brain of rats subjected to the forced s ... Full text Cite

Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain.

Journal Article Investigacion clinica · December 1996 Manganese (Mn) poisoning is characterized by central nervous system manifestations, including psychiatric disturbances and extrapyramidal disorders. This metal is thought to produce neuronal degeneration due to cytotoxic products originated by oxidative st ... Cite

Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neurons.

Journal Article Neuroscience letters · July 1995 We have previously reported that morphine produces a concentration-dependent multiphasic modulation (inhibitions and facilitations) of substance P (SP) release from trigeminal nucleus caudalis slices by activation of distinct populations of mu-, delta- and ... Full text Cite

Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning.

Journal Article Life sciences · January 1995 Manganese (Mn) poisoning in man produces an early psychotic disorder that is later followed by a Parkinson-like syndrome. Since alterations in the brain DA system are thought to be involved, we assessed the presynaptic autoreceptor regulation of K(+)-evoke ... Full text Cite

Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices.

Journal Article The Journal of pharmacology and experimental therapeutics · February 1993 The modulation of the release of substance P (SP) from sensory primary afferents by activation of kappa opioid receptors is not only equivocal, but also contradictory. Thus, in the present study, we have determined the effect of nanomolar concentrations of ... Cite

Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices.

Journal Article European journal of pharmacology · December 1992 The release of substance P (SP) from spinal dorsal horn slices is partially inhibited by micromolar concentrations of selective delta-opioid receptor agonists. In the present study, we have examined the effect of nanomolar concentrations of [D-Pen2,D-Pen5] ... Full text Cite

Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptor subtypes.

Journal Article Brain research · May 1992 Morphine (MOR) produces a concentration-dependent multiphasic effect (inhibitions and facilitations) on K(+)-evoked substance P (SP) release from rat trigeminal nucleus slices. In this study, we tested the action of selective opioid receptor antagonists on ... Full text Cite

Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices.

Journal Article Brain research · May 1992 It is generally accepted that morphine acts presynaptically to inhibit substance P (SP) release from afferent terminals in the trigeminal nucleus. Recent studies, however, provide evidence that opioids produce both inhibitory and excitatory effects on SP r ... Full text Cite

Sensitizing effects of leukotriene B4 on intradental primary afferents.

Journal Article Pain · April 1992 Previous studies have established that leukotriene B4 (LTB4) sensitizes cutaneous nociceptors. In this study the effects of LTB4 on spontaneous and stimulus-evoked nerve activity from primary afferents innervating the dentin of canines in adult cats were e ... Full text Cite

[Spontaneous motor activity in mice overloaded with iron-dextran].

Journal Article Investigacion clinica · January 1992 We studied the spontaneous motor activity and the levels of iron in brain (frontal cortex and striatum) and liver of mice overloaded with iron dextran. Two groups of mice injected intraperitoneally with two different doses of iron and the control group wer ... Cite

Nutritional evaluation of Huntington disease patients.

Journal Article Am J Clin Nutr · July 1989 A nutritional survey and evaluation was made in Huntington disease patients by the 24-h-recall method. Control subjects and choreic patients consumed a diet that supplied all the essential amino acids. The diet was hypocaloric, rich in animal protein, and ... Full text Link to item Cite

Comparative dopamine-cholinergic mechanisms in the olfactory tubercle and the striatum: effects of metoclopramide.

Journal Article The Journal of pharmacology and experimental therapeutics · December 1987 The olfactory tubercle (OT) is a limbic structure containing high dopamine (DA) and acetylcholine (ACh) concentrations. We performed a comparative study of the DA-ACh interactions, the efficacy of autoreceptor control and the effects of metoclopramide in t ... Cite