Yangzhong Huang

Journal Article Neuropharmacology · May 1, 2020 Traumatic brain injury (TBI) and status epilepticus (SE) have both been linked to development of human epilepsy. Although distinct etiologies, current research has suggested the convergence of molecular mechanisms underlying epileptogenesis following these ... Full text Link to item Cite

Regression of Epileptogenesis by Inhibiting Tropomyosin Kinase B Signaling following a Seizure.

Journal Article Ann Neurol · December 2019 OBJECTIVE: Temporal lobe epilepsy (TLE) is a devastating disease in which seizures persist in 35% of patients despite optimal use of antiseizure drugs. Clinical and preclinical evidence implicates seizures themselves as one factor promoting epilepsy progre ... Full text Open Access Link to item Cite

TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.

Journal Article J Neurosci · June 5, 2019 Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy for which only symptomatic therapy is available. One cause of TLE is an episode of de novo prolonged seizures [status epilepticus (SE)]. Understanding the molecular si ... Full text Open Access Link to item Cite

Vagal nerve stimulation modifies neuronal activity and the proteome of excitatory synapses of amygdala/piriform cortex.

Journal Article J Neurochem · February 2017 Vagal Nerve Stimulation (VNS) Therapy® is a United States Food and Drug Administration approved neurotherapeutic for medically refractory partial epilepsy and treatment-resistant depression. The molecular mechanisms underlying its beneficial effects are un ... Full text Link to item Cite

A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.

Journal Article Neuron · November 4, 2015 The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in both health and disease. Excessive activation of TrkB caused by status epilepticus promotes development of temporal lobe epilepsy (TLE), revealing TrkB as a therapeutic target fo ... Full text Open Access Link to item Cite

Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo.

Journal Article J Comp Neurol · December 1, 2014 The neurotrophin receptor, TrkB receptor tyrosine kinase, is critical to central nervous system (CNS) function in health and disease. Elucidating the ligands mediating TrkB activation in vivo will provide insights into its diverse roles in the CNS. The can ... Full text Link to item Cite

Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB.

Journal Article J Neurosci · October 31, 2012 Reactive oxygen species (ROS) have diverse biological consequences in the mammalian CNS, but the molecular targets mediating these pleiotropic effects are incompletely understood. Like ROS, the neurotrophin receptor, TrkB receptor tyrosine kinase, has dive ... Full text Link to item Cite

RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB.

Journal Article Mol Pharmacol · October 2012 Many cell surface signaling receptors, such as the neurotrophin receptor, TrkB, have emerged as potential therapeutic targets for diverse diseases. Reduced activation of TrkB in particular is thought to contribute to neurodegenerative diseases. Unfortunate ... Full text Link to item Cite

Mutual regulation of Src family kinases and the neurotrophin receptor TrkB.

Journal Article J Biol Chem · March 12, 2010 The neurotrophin receptor tyrosine kinase TrkB is critical to diverse biological processes. We investigated the interplay of Src family kinases (SFKs) and TrkB to better understand mechanisms of TrkB signaling in physiological and pathological conditions. ... Full text Link to item Cite

Targeting inhibition of GluR1 Ser845 phosphorylation with an RNA aptamer that blocks AMPA receptor trafficking.

Journal Article J Neurochem · January 2009 Phosphorylation at glutamate receptor subunit 1(GluR1) Ser845 residue has been widely accepted to involve in GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking, but the in vivo evidence has not yet been es ... Full text Link to item Cite

Plasticity of dentate granule cell mossy fiber synapses: A Putative mechanism of limbic epileptogenesis

Journal Article · December 1, 2008 The epilepsies constitute the third most common serious neurological disorder. Among the more than 40 different types of epilepsy, limbic epilepsy is the single most common and devastating form. Antiseizure drugs provide symptomatic relief, in that they su ... Full text Cite

Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse.

Journal Article Neuron · February 28, 2008 The receptor tyrosine kinase, TrkB, is critical to diverse functions of the mammalian nervous system in health and disease. Evidence of TrkB activation during epileptogenesis in vivo despite genetic deletion of its prototypic neurotrophin ligands led us to ... Full text Link to item Cite

Neuregulin-1 enhances depolarization-induced GABA release.

Journal Article Neuron · May 24, 2007 Neuregulin-1 (NRG1), a regulator of neural development, has been shown to regulate neurotransmission at excitatory synapses. Although ErbB4, a key NRG1 receptor, is expressed in glutamic acid decarboxylase (GAD)-positive neurons, little is known about its ... Full text Link to item Cite

Inhibiting glycolysis to reduce seizures: how it might work.

Journal Article Nat Neurosci · November 2006 Full text Link to item Cite

Molecular signaling mechanisms underlying epileptogenesis.

Journal Article Sci STKE · October 10, 2006 Epilepsy, a disorder of recurrent seizures, is a common and frequently devastating neurological condition. Available therapy is only symptomatic and often ineffective. Understanding epileptogenesis, the process by which a normal brain becomes epileptic, ma ... Full text Link to item Cite

Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors.

Journal Article Mol Cell Neurosci · February 2005 Neuregulin-induced expression of the acetylcholine receptor (AChR) contributes to high concentration of the receptor at the neuromuscular junction (NMJ). Neuregulin-1 activates ErbB tyrosine kinases and subsequently intracellular kinases including Erk that ... Full text Link to item Cite

Ischemic stroke: "acidotoxicity" is a perpetrator.

Journal Article Cell · September 17, 2004 Ischemic stroke is a devastating neurological disease. The responsible mechanisms are not completely understood. In this issue of Cell, Xiong et al. (2004) elucidate a molecular mechanism by which acidosis damages the brain during ischemia. ... Full text Link to item Cite

Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.

Journal Article FASEB J · November 2003 Connector enhancer of KSR (CNK) is a multidomain protein that participates in Ras signaling in Drosophila eye development. In this report we identify the human homologue of CNK, termed CNK2A, and a truncated alternatively spliced variant, CNK2B. We charact ... Full text Link to item Cite

Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.

Journal Article J Neurosci · April 15, 2003 Neuregulin (NRG) regulates synapse formation and synaptic plasticity, but little is known about the regulation of NRG signaling at synapses. Here we show that the NRG receptor ErbB4 was localized in anatomically defined postsynaptic densities in the brain. ... Full text Link to item Cite

Erbin suppresses the MAP kinase pathway.

Journal Article J Biol Chem · January 10, 2003 We present evidence here that Erbin is a negative regulator of the Ras-Raf-Erk signaling pathway. Expression of Erbin decreases transcription of the AChR epsilon-subunit gene, an event that is mediated by Erk activation. Although it interacts with the ErbB ... Full text Link to item Cite

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

Journal Article J Biol Chem · February 22, 2002 An unusual protease gamma-secretase requires functional presenilins and cleaves substrates (e.g. amyloid beta-protein precursor and Notch) with very loose amino acid sequence specificity within the transmembrane region. Here we report that ErbB4, a tyrosin ... Full text Link to item Cite

Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.

Journal Article Int J Dev Neurosci · 2002 The synapse-specific synthesis of the acetylcholine receptor (AChR) is mediated by multiple mechanisms including compartmentalized signaling induced by neuregulin (NRG). This paper presents evidence that NRG receptors--ErbB receptor tyrosine kinases intera ... Full text Link to item Cite

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

Journal Article Cell · October 19, 2001 The Slit protein guides neuronal and leukocyte migration through the transmembrane receptor Roundabout (Robo). We report here that the intracellular domain of Robo interacts with a novel family of Rho GTPase activating proteins (GAPs). Two of the Slit-Robo ... Full text Link to item Cite

[Neuregulin/ErbB signal transduction pathway in the development of nervous system].

Journal Article Sheng Li Ke Xue Jin Zhan · July 2001 Neuregulins are a family of structurally-related polypeptides encoded by four distinct genes. Three isoforms of neuregulin (NRG1, 2, and 3) are highly expressed in the developing and adult brain, among which NRG1 is best characterized. NRG1 has multiple fu ... Link to item Cite

Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95.

Journal Article J Biol Chem · June 1, 2001 Neuregulin is a factor essential for synapse-specific transcription of acetylcholine receptor genes at the neuromuscular junction. Its receptors, ErbB receptor tyrosine kinases, are localized at the postjunctional membrane presumably to ensure localized si ... Full text Link to item Cite

Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.

Journal Article J Cell Biol · March 5, 2001 Proline-rich tyrosine kinase 2 (PYK2), a tyrosine kinase structurally related to focal adhesion kinase (FAK), is implicated in regulating cytoskeletal organization. However, mechanisms by which PYK2 participates in and regulates cytoskeletal organization r ... Full text Link to item Cite

Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.

Journal Article Neuron · May 2000 Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for neuronal development, but their functions in the adult CNS are unknown. We report that ErbB4 is enriched in the postsynaptic density (PSD) and associates with PSD- ... Full text Link to item Cite

Expression of PSD-95/SAP90 is critical for N-methyl-D-aspartate receptor-mediated thermal hyperalgesia in the spinal cord.

Journal Article Neuroscience · 2000 PSD-95/SAP90, a molecular scaffold protein, attaches the N-methyl-D-aspartate receptor to cellular signaling pathways through PSD-95/DLG/Z0-1 domain interactions at neuronal synapses.(5,9) This suggests that PSD-95/SAP90 might be involved in many physiolog ... Full text Link to item Cite