Huihua Li

Journal Article Cardiovasc Pathol · 2026 BACKGROUND: The pathologic definition for antibody-mediated rejection (AMR) includes both histopathological and immunopathological components. C4d is the most validated diagnostic marker for immunopathologic AMR; however, the clinical significance of early ... Full text Link to item Cite

Quantifying partial pathological response rate in prostate cancer patients who underwent neoadjuvant chemotherapy using a novel morphometric approach

Journal Article Journal of Pathology Informatics · November 1, 2025 Accurate assessment of partial pathological response rate (ppRR) to neoadjuvant chemotherapy (NAT) is critical for assessing the efficacy of therapy and for optimal clinical management. Because of a lack of accurate estimation of baseline cancer burden, as ... Full text Cite

Mechanisms of Cardiac Implantable Electronic Device Interference With the Tricuspid Valve Apparatus.

Journal Article Am J Cardiol · September 1, 2025 Cardiac implantable electronic devices (CIEDs) have been implicated in the development of tricuspid valve (TV) dysfunction. However, the mechanisms of dysfunction are not well characterized. We sought to define the prevalence, location and mechanisms of CI ... Full text Link to item Cite

Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial.

Journal Article Nat Commun · January 2, 2025 GT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor H that kills tumor cells and promotes anti-cancer immunity in preclinical models. We conducted a first-in-human phase 1b study dose escalation trial of GT103 in re ... Full text Open Access Link to item Cite

Recent trends in the causation of peritoneal mesothelioma: fiber burden analysis of ten cases.

Journal Article Ultrastruct Pathol · 2025 Mesothelioma in the past has been strongly associated with a history of asbestos exposure. Studies have shown that, on average, a higher dose of asbestos exposure is required for the development of peritoneal mesothelioma, and a smaller percentage of cases ... Full text Link to item Cite

Carcinoma of the Lung

Chapter · January 1, 2025 Carcinoma of the lung is the number one cause of cancer mortality in the United States. The primary cause of this highly fatal malignancy is cigarette smoking, which accounts for at least 85% of cases. Asbestos is a contributing factor in a small percentag ... Full text Cite

Asbestos Bodies and Non-asbestos Ferruginous Bodies

Chapter · January 1, 2025 Biopersistent mineral fibers deposited in the lower respiratory tract that measure 15–20 microns or greater in length are taken up by alveolar macrophages. In a process referred to as frustrated phagocytosis, these macrophages coat the fibers with an iron ... Full text Cite

Analysis of Tissue Mineral Fiber Content

Chapter · January 1, 2025 Mineral fibers may be identified in the lungs of most individuals from industrialized societies. When present in excessive amounts, the accumulation of these fibers may result in several diseases. At lower levels, there is an increased risk of mesothelioma ... Full text Cite

Nonmesothelial Spindle Cell Tumors of Pleura and Pericardium.

Journal Article Surg Pathol Clin · June 2024 Spindle cell lesions of the pleura and pericardium are rare. Distinction from sarcomatoid mesothelioma, which has a range of morphologic patterns, can be difficult, but accurate diagnosis matters. This article provides practical guidance for the diagnosis ... Full text Link to item Cite

Mesothelioma in situ of the peritoneum: report of three cases and review of the literature.

Journal Article Histopathology · February 2024 AIM: Diagnosis of mesothelioma in situ (MIS) is historically controversial and, until recently, specific features defining the entity have not been well characterized. Most reported cases of MIS occurred in the pleura; peritoneal MIS is very rare. This stu ... Full text Link to item Cite

Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice.

Journal Article Physiol Rep · January 2024 Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials with supplemental ... Full text Link to item Cite

BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection.

Journal Article Am J Physiol Lung Cell Mol Physiol · November 1, 2023 Basic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is emerging as an important regulator of the innate immune system. BATF2 is among the top upregulated genes in human alveolar macrophages treated with LPS, but the ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

Pulmonary Alveolar Proteinosis-associated Pulmonary Fibrosis: Evolutional Changes and Radiologic-Pathologic Correlation.

Journal Article Radiol Cardiothorac Imaging · October 2023 Pulmonary alveolar proteinosis (PAP) is a rare disease with frequently favorable outcomes. In a minority of patients with primary or secondary PAP, the disease course may be complicated by pulmonary fibrosis (PF) despite appropriate management. Imaging and ... Full text Link to item Cite

Mediastinal Synovial Sarcoma 14 Years After Talc Pleurodesis for Spontaneous Pneumothorax

Journal Article Annals of Thoracic Surgery Short Reports · September 2023 Full text Cite

Deep learning generates synthetic cancer histology for explainability and education.

Journal Article NPJ Precis Oncol · May 29, 2023 Artificial intelligence methods including deep neural networks (DNN) can provide rapid molecular classification of tumors from routine histology with accuracy that matches or exceeds human pathologists. Discerning how neural networks make their predictions ... Full text Link to item Cite

RNA sequencing analysis of hepatocellular carcinoma identified oxidative phosphorylation as a major pathologic feature.

Journal Article Hepatol Commun · August 2022 Dysregulation of expression of functional genes and pathways plays critical roles in the etiology and progression of hepatocellular carcinoma (HCC). Next generation-based RNA sequencing (RNA-seq) offers unparalleled power to comprehensively characterize HC ... Full text Link to item Cite

Primary lung secretory carcinoma: a case report

Journal Article Precision Cancer Medicine · March 1, 2022 Lung salivary gland-like tumors are histolgocaly similar to those found in the major and minor salivary glands of the head and neck region. These primary lung tumors are exceedingly rare, but various types of salivary gland-like carcinomas have been report ... Full text Cite

LncRNA expression and SDHB mutations in pheochromocytomas and paragangliomas.

Journal Article Ann Diagn Pathol · December 2021 Although pheochromocytomas and paragangliomas (PPGLs) are usual low-grade neoplasms, the metastatic forms of these lesions are associated with high morbidity and mortality. Recent studies have discovered multiple aberrantly expressed long non-coding RNAs ( ... Full text Link to item Cite

Plasmapheresis, Rituximab, and Ceftriaxone Provided Lasting Improvement for a 27-Year-Old Adult Male with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS).

Journal Article Case Rep Psychiatry · 2021 Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a specific autoimmune response to group-A streptococcal (GAS) infections in children and adolescents with a sudden onset of neuropsychiatric disorders incl ... Full text Link to item Cite

Increased Alternative Complement Pathway Function and Improved Survival during Critical Illness.

Journal Article Am J Respir Crit Care Med · July 15, 2020 Rationale: Complement is crucial for host defense but may also drive dysregulated inflammation. There is limited understanding of alternative complement function, which can amplify all complement activity, during critical illness.Objectives: We examined th ... Full text Link to item Cite

IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury.

Journal Article JCI Insight · March 21, 2019 Acute respiratory distress syndrome is an often fatal disease that develops after acute lung injury and trauma. How released tissue damage signals, or alarmins, orchestrate early inflammatory events is poorly understood. Herein we reveal that IL-33, an ala ... Full text Link to item Cite

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury.

Journal Article Blood Adv · February 12, 2019 Thrombocytopenia is associated with worse outcomes in patients with acute respiratory distress syndrome, which is most commonly caused by infection and marked by alveolar-capillary barrier disruption. However, the mechanisms by which platelets protect the ... Full text Link to item Cite

CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis.

Journal Article J Infect Dis · December 15, 2016 Klebsiella pneumoniae remains an important cause of intrapulmonary infection and invasive disease worldwide. K. pneumoniae can evade serum killing and phagocytosis primarily through the expression of a polysaccharide capsule, but its pathogenicity is also ... Full text Link to item Cite

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.

Journal Article J Biol Chem · April 8, 2016 Idiopathic pulmonary fibrosis is a disease characterized by progressive, unrelenting lung scarring, with death from respiratory failure within 2-4 years unless lung transplantation is performed. New effective therapies are clearly needed. Fibroblast activa ... Full text Link to item Cite

Effect of transporter and DNA repair gene polymorphisms to lung cancer chemotherapy toxicity.

Journal Article Tumour Biol · February 2016 Lung cancer is the first leading cause of cancer deaths. Chemotherapy toxicity is one of factors that limited the efficacy of platinum-based chemotherapy in lung cancer patients. Transporters and DNA repair genes play critical roles in occurrence of platin ... Full text Link to item Cite

Zinc Homeostasis in Lung

Chapter · March 18, 2015 Zinc is an essential trace metal whose intracellular levels ([Zn]i) are maintained by a dynamic process of transport, intracellular vesicular storage, and binding to a large number of proteins including metalloenzymes, structural proteins, and t ... Full text Cite

Zinc Homeostasis in Lung

Chapter · March 13, 2015 This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. ... Cite

Comparison of the relative propensities of isoamyl nitrite and sodium nitrite to ameliorate acute cyanide poisoning in mice and a novel antidotal effect arising from anesthetics.

Journal Article Chem Res Toxicol · May 20, 2013 Isoamyl nitrite has previously been considered acceptable as an inhaled cyanide antidote; therefore, the antidotal utility of this organic nitrite compared with sodium nitrite was investigated. To facilitate a quantitative comparison, doses of both sodium ... Full text Link to item Cite

Caveolae-dependent and -independent uptake of albumin in cultured rodent pulmonary endothelial cells.

Journal Article PLoS One · 2013 Although a critical role for caveolae-mediated albumin transcytosis in pulmonary endothelium is well established, considerably less is known about caveolae-independent pathways. In this current study, we confirmed that cultured rat pulmonary microvascular ... Full text Link to item Cite

WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury.

Journal Article Am J Respir Cell Mol Biol · October 2012 Although strides have been made to reduce ventilator-induced lung injury (VILI), critically ill patients can vary in sensitivity to VILI, suggesting gene-environment interactions could contribute to individual susceptibility. This study sought to uncover c ... Full text Link to item Cite

Acute, sublethal cyanide poisoning in mice is ameliorated by nitrite alone: complications arising from concomitant administration of nitrite and thiosulfate as an antidotal combination.

Journal Article Chem Res Toxicol · July 18, 2011 Sodium nitrite alone is shown to ameliorate sublethal cyanide toxicity in mice when given from ∼1 h before until 20 min after the toxic dose as demonstrated by the recovery of righting ability. An optimum dose (12 mg/kg) was determined to significantly rel ... Full text Link to item Cite

Cytoprotective effects of albumin, nitrosated or reduced, in cultured rat pulmonary vascular cells.

Journal Article Am J Physiol Lung Cell Mol Physiol · April 2011 S-nitrosoalbumin (SNO-Alb) has been shown to be an efficacious cytoprotective molecule in acute lung injury, as well as ischemia-reperfusion injury in heart and skeletal muscle. Nonetheless, limited information is available on the cellular mechanism of suc ... Full text Link to item Cite

Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice.

Journal Article Anesthesiology · September 2010 BACKGROUND: The mechanisms of ventilator-induced lung injury, an iatrogenic inflammatory condition induced by mechanical ventilation, are not completely understood. Toll-like receptor 4 (TLR4) signaling via the adaptor protein myeloid differentiation facto ... Full text Link to item Cite

Nitric oxide and zinc homeostasis in pulmonary endothelium.

Journal Article Ann N Y Acad Sci · August 2010 We have shown that zinc-thiolate moieties of the metal binding protein metallothionein (MT) are critical targets for nitric oxide (NO) with resultant increases in intracellular labile zinc. Such an NO-MT-Zn signaling pathway appears to participate in impor ... Full text Link to item Cite

Effect of St. John's wort supplementation on the pharmacokinetics of bupropion in healthy male Chinese volunteers.

Journal Article Xenobiotica · April 2010 The objective of this study was to investigate the effects of continuous St. John's wort administration on single-dose pharmacokinetics of bupropion, a substrate of cytochrome P450 (CYP) 2B6, in healthy Chinese volunteers. Eighteen unrelated healthy male s ... Full text Link to item Cite

The effect of β3-AR Trp64Arg on rosiglitazone response in T2DM patients

Journal Article Chinese Pharmacological Bulletin · January 1, 2009 Aim: To explore the impact of β3-adrenergic receptor (ADRB3) genetic variation on therapeutic efficacy of rosiglitazone in Chinese T2DM patients. Methods: The genotypes of ADRB3 Trp64Arg in 255 T2DM patients and 148 healthy volunteers were deter ... Cite

Construction of high efficient eukaryotic expression vector carrying human β3-adrenoceptor gene and its significance

Journal Article Chinese Pharmacological Bulletin · January 1, 2008 Aim: A high efficient eukaryotic expression vector carrying human β3-adrenoceptor (AR) genes was constructed to investigate the function of human β3-AR and interaction between β3-AR and PPAR-γ2 gene. Methods: The paranephri ... Cite

Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes.

Journal Article Clin Chem Lab Med · 2007 BACKGROUND: The aim of the present study was to investigate whether histamine induces up-regulated expression of uncoupling protein 2 (UCP2) and fat acid-binding protein (aP2) in white adipocytes (differentiated 3T3-L1 cells). METHODS: Differentiation of 3 ... Full text Link to item Cite

The genetic polymorphisms of beta3-adrenergic receptor (AR) Trp64Arg and beta2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients.

Journal Article Clin Chem Lab Med · 2007 BACKGROUND: Genetic polymorphisms of beta3-adrenergic receptor (AR) Trp64Arg and beta2-AR Gln27Glu may result in significant change in the functions of these receptors. The aims of the present study were to investigate the association between Trp64Arg, Arg ... Full text Link to item Cite