Scholars@Duke
Jeffrey Charles Gadsden

Jeffrey Charles Gadsden

Professor of Anesthesiology
Anesthesiology, Regional

Selected Publications

A Phase I Study of the Pharmacokinetics, Pharmacodynamics, and Safety of Liposomal Bupivacaine for Sciatic Nerve Block in the Popliteal Fossa for Bunionectomy.

Journal Article J Clin Pharmacol · November 8, 2024 This trial assessed the pharmacokinetics, pharmacodynamics, and safety of liposomal bupivacaine given via ultrasound-guided popliteal sciatic nerve block with or without immediate-release bupivacaine hydrochloride in adults having bunionectomies. Forty-fiv ... Full text Link to item Cite

Standardizing nomenclature in regional anesthesia: an ASRA-ESRA Delphi consensus study of upper and lower limb nerve blocks.

Journal Article Reg Anesth Pain Med · November 4, 2024 BACKGROUND: Inconsistent nomenclature and anatomical descriptions of regional anesthetic techniques hinder scientific communication and engender confusion; this in turn has implications for research, education and clinical implementation of regional anesth ... Full text Link to item Cite

Single-shot interscalene block with liposomal bupivacaine vs. non-liposomal bupivacaine in shoulder arthroplasty.

Journal Article J Shoulder Elbow Surg · July 20, 2024 BACKGROUND: Regional anesthesia is a valuable component of multimodal pain control in total shoulder arthroplasty (TSA), and multiple interscalene block anesthetic options exist, including nonliposomal interscalene bupivacaine (NLIB) and liposomal intersca ... Full text Link to item Cite

Relationship between injectate volume and disposition in erector spinae plane block: a cadaveric study.

Journal Article Reg Anesth Pain Med · July 8, 2024 INTRODUCTION: Erector spinae plane (ESP) blocks can be used to provide analgesia following thoracoabdominal and lumbar spine surgical procedures. However, the influence of injectate volume and injection location on the spread of anesthetic with ESP blocks ... Full text Link to item Cite

A phase 3 active-controlled trial of liposomal bupivacaine via sciatic nerve block in the popliteal fossa after bunionectomy.

Journal Article J Clin Anesth · June 2024 STUDY OBJECTIVE: To investigate the efficacy, safety, pharmacodynamics, and pharmacokinetics of liposomal bupivacaine (LB) administered via ultrasound-guided sciatic nerve block in the popliteal fossa in participants undergoing bunionectomy. DESIGN: Two-pa ... Full text Link to item Cite

Practice 'safe scans': why ultrasound transducer covers should be considered best practice.

Journal Article Reg Anesth Pain Med · May 21, 2024 Single-injection, ultrasound-guided nerve block procedures involve puncturing the skin in close proximity to an ultrasound transducer, creating a potential vector for transmission of microbial organisms when skin flora and blood come into contact with the ... Full text Link to item Cite

Cognitive and Cerebrospinal Fluid Alzheimer's Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls.

Conference Anesthesiology · May 1, 2024 BACKGROUND: Anesthesia and/or surgery accelerate Alzheimer's disease pathology and cause memory deficits in animal models, yet there is a lack of prospective data comparing cerebrospinal fluid (CSF) Alzheimer's disease-related biomarker and cognitive traje ... Full text Link to item Cite

Infraclavicular versus costoclavicular approaches to ultrasound-guided brachial plexus block: a systematic review and meta-analysis.

Journal Article Braz J Anesthesiol · 2024 BACKGROUND: The costoclavicular approach to brachial plexus block may have a more favorable anatomy than the classic infraclavicular approach. However, there are conflicting results in the literature regarding the comparative effectiveness of these two tec ... Full text Link to item Cite

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders among Older Noncardiac Surgery Patients: A Cohort Study

Journal Article Anesthesia and Analgesia · January 1, 2024 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Cite

Pericapsular Nerve Group (PENG) Block

Chapter · January 1, 2024 The pericapsular nerve group (or PENG) block is a regional anesthesia technique designed to anesthetize a number of small articular nerve branches that supply the anterior and medial joint capsule as well as much of the articular surfaces of the femur and ... Full text Cite

Superior Trunk Block Is an Effective Phrenic-Sparing Alternative to Interscalene Block for Shoulder Arthroscopy: A Systematic Review and Meta-Analysis.

Journal Article Cureus · November 2023 The interscalene block (ISB) is the standard regional anesthesia for shoulder arthroscopy. However, the superior trunk block (STB) is an alternative with a potentially safer profile. This meta-analysis aimed to compare the incidence and degree of hemidiaph ... Full text Link to item Cite

Lower Extremity Peripheral Nerve Blocks for Patients at Risk for Acute Compartment Syndrome.

Journal Article Orthop Clin North Am · October 2023 A delayed acute compartment syndrome (ACS) diagnosis often results in devastating complications; however, the sensitivity of the classic signs and symptoms is very low. All analgesic modalities have been implicated in delaying the diagnosis, but there is v ... Full text Link to item Cite

Awake Spinal Fusion Is Associated with Reduced Length of Stay, Opioid Use, and Time to Ambulation Compared to General Anesthesia: A Matched Cohort Study.

Journal Article World Neurosurg · August 2023 OBJECTIVE: There is increasing interest in performing awake spinal fusion under spinal anesthesia (SA). Evidence supporting SA has been positive, albeit limited. The authors set out to investigate the effects of SA versus general anesthesia (GA) for spinal ... Full text Open Access Link to item Cite

Awake spinal anesthesia facilitates spine surgery in poor surgical candidates: A case series.

Journal Article Neurochirurgie · May 2023 BACKGROUND: Annually, hundreds of thousands of patients undergo surgery for degenerative spine disease (DSD). This represents only a fraction of patients that present for surgical consideration. Procedures are often avoided due to comorbidities that make p ... Full text Open Access Link to item Cite

The failed peripheral nerve block.

Journal Article BJA Educ · March 2023 Full text Link to item Cite

Interscalene block with liposomal bupivacaine versus continuous interscalene catheter in primary total shoulder arthroplasty.

Journal Article J Shoulder Elbow Surg · October 2022 BACKGROUND: Multimodal pain regimens in total shoulder arthroplasty (TSA) now include regional anesthetic techniques. Historically, regional anesthesia for extended postoperative pain control in TSA was administered using a continuous interscalene catheter ... Full text Link to item Cite

Recommendations for effective documentation in regional anesthesia: an expert panel Delphi consensus project.

Journal Article Reg Anesth Pain Med · May 2022 BACKGROUND AND OBJECTIVES: Documentation is important for quality improvement, education, and research. There is currently a lack of recommendations regarding key aspects of documentation in regional anesthesia. The aim of this study was to establish recom ... Full text Link to item Cite

Regional Anesthesia Associated With Decreased Inpatient and Outpatient Opioid Demand in Tibial Plateau Fracture Surgery.

Journal Article Anesth Analg · May 1, 2022 BACKGROUND: Regional anesthesia (RA) has been used to reduce pain and opioid usage in elective orthopedic surgery. The hypothesis of this study was that RA would be associated with decreased opioid demand in tibial plateau fracture surgery. METHODS: Inpati ... Full text Link to item Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.

Journal Article Br J Anaesth · December 2021 BACKGROUND: Cognitive dysfunction after surgery is a major issue in older adults. Here, we determined the effect of APOE4 on perioperative neurocognitive function in older patients. METHODS: We enrolled 140 English-speaking patients ≥60 yr old scheduled fo ... Full text Open Access Link to item Cite

Ultrasound-guided genicular nerve blocks following total knee arthroplasty: a randomized, double-blind, placebo-controlled trial.

Journal Article Reg Anesth Pain Med · October 2021 INTRODUCTION: Local anesthetic blockade of the genicular nerves, known targets of radiofrequency ablative techniques for knee pain, has not previously been studied in a randomized controlled trial evaluating acute pain after knee arthroplasty. We hypothesi ... Full text Link to item Cite

Standardizing nomenclature in regional anesthesia: an ASRA-ESRA Delphi consensus study of abdominal wall, paraspinal, and chest wall blocks.

Journal Article Reg Anesth Pain Med · July 2021 BACKGROUND: There is heterogeneity in the names and anatomical descriptions of regional anesthetic techniques. This may have adverse consequences on education, research, and implementation into clinical practice. We aimed to produce standardized nomenclatu ... Full text Link to item Cite

A Case Report of Bilateral Phrenic Nerve Dysfunction After Unilateral Supraclavicular Brachial Plexus Block: Unveiling Preexisting Diaphragmatic Dysfunction.

Journal Article A A Pract · March 30, 2021 A 48-year-old woman with a history of cardiac surgery developed severe dyspnea and anxiety following right-sided supraclavicular nerve block for hand surgery. In this case, right phrenic nerve blockade from a supraclavicular block unmasked a subclinical he ... Full text Link to item Cite

Femoral artery block (FAB) attenuates thigh tourniquet-induced hypertension: a prospective randomized, double-blind, placebo-controlled trial.

Journal Article Reg Anesth Pain Med · March 2021 INTRODUCTION: Prolonged tourniquet inflation during surgery frequently leads to tourniquet hypertension (TH), which is thought to arise from compression of A-δ fibers leading to sympathetically mediated C fiber activation. In the lower extremity, C fibers ... Full text Link to item Cite

Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.

Journal Article Sci Rep · February 4, 2021 Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in perioperative neurocognitive disorders, yet th ... Full text Open Access Link to item Cite

The role of peripheral nerve stimulation in the era of ultrasound-guided regional anaesthesia.

Journal Article Anaesthesia · January 2021 With the widespread use of ultrasound for localising nerves during peripheral nerve blockade, the value of electrical nerve stimulation of evoked motor responses has been questioned. Studies continue to show that, compared with nerve stimulation, ultrasoun ... Full text Link to item Cite

Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2021 BACKGROUND: Postoperative cognitive dysfunction (POCD), a syndrome of cognitive deficits occurring 1-12 months after surgery primarily in older patients, is associated with poor postoperative outcomes. POCD is hypothesized to result from neuroinflammation; ... Full text Open Access Link to item Cite

Transversus Abdominis Plane Block With Liposomal Bupivacaine for Pain After Cesarean Delivery in a Multicenter, Randomized, Double-Blind, Controlled Trial.

Journal Article Anesth Analg · December 2020 BACKGROUND: In women undergoing cesarean delivery under spinal anesthesia with intrathecal morphine, transversus abdominis plane (TAP) block with bupivacaine hydrochloride (HCl) may not improve postsurgical analgesia. This lack of benefit could be related ... Full text Link to item Cite

The relative analgesic value of a femoral nerve block versus adductor canal block following total knee arthroplasty: a randomized, controlled, double-blinded study.

Journal Article Korean J Anesthesiol · October 2020 BACKGROUND: Multiple comparative studies report that adductor canal blocks provide similar pain relief to femoral nerve blocks following total knee arthroplasty. However, adductor canal blockade fails to anesthetize several important femoral nerve branches ... Full text Open Access Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Does Ultrasonographic Measurement of Gastric Content Influence Airway Management Decisions?

Journal Article AANA J · April 2020 The presence of gastric content before induction of general anesthesia is the primary modifiable risk factor in the prevention of pulmonary aspiration. The purpose of this project was to determine if ultrasonography could be routinely used to measure gastr ... Link to item Cite

Brachial Plexus Block with Liposomal Bupivacaine for Shoulder Surgery Improves Analgesia and Reduces Opioid Consumption: Results from a Multicenter, Randomized, Double-Blind, Controlled Trial.

Journal Article Pain Med · February 1, 2020 OBJECTIVE: The utility of single-injection and continuous peripheral nerve blocks is limited by short duration of analgesia and catheter-related complications, respectively. This double-blind, multicenter trial evaluated the efficacy, safety, and pharmacok ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.

Journal Article Anesth Analg · November 2019 Animal models suggest postoperative cognitive dysfunction may be caused by brain monocyte influx. To study this in humans, we developed a flow cytometry panel to profile cerebrospinal fluid (CSF) samples collected before and after major noncardiac surgery ... Full text Open Access Link to item Cite

Use of Near-Infrared Spectroscopy to Measure Tissue Oxygen Saturation During Total Knee Arthroplasty With Use of a Tourniquet.

Journal Article AANA J · June 2019 The primary purpose of this proof-of-concept quality improvement effort was to evaluate the practicality of using near-infrared spectroscopy (NIRS) to measure tissue oxygen saturation (Sto2) during total knee arthroplasty (TKA) with use of a tourniquet. NI ... Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Pressure monitoring: The evidence so far.

Journal Article Best Pract Res Clin Anaesthesiol · March 2019 Nerve injury is a relatively rare but devastating complication of peripheral nerve blockade (PNB). Monitoring injection pressure during PNB is one method advocated to prevent injury by detecting needle tip placement in a noncompliant position (intraneural ... Full text Link to item Cite

Updates in Enhanced Recovery Pathways for Total Knee Arthroplasty.

Journal Article Anesthesiol Clin · September 2018 Enhanced recovery after surgery (ERAS) programs for orthopedics involve a multidisciplinary approach to accelerating return to function, reducing pain, improving patient comfort and satisfaction, reducing complications from the surgical procedure, reducing ... Full text Link to item Cite

Current devices used for the monitoring of injection pressure during peripheral nerve blocks.

Journal Article Expert Rev Med Devices · August 2018 INTRODUCTION: Peripheral nerve blocks are generally safe. However, there is a small but real associated risk of needle-related complications such as nerve injury. Nerve injury has been associated with high pressure injections in animals, and some data supp ... Full text Link to item Cite

The Use of Liposomal Bupivacaine in Erector Spinae Plane Block to Minimize Opioid Consumption for Breast Surgery: A Case Report.

Journal Article A A Pract · May 1, 2018 The erector spinae plane block is a novel interfascial plane block that can provide thoracic and abdominal analgesia. We describe a patient with opioid intolerance scheduled for breast surgery who received an erector spinae plane block with liposomal bupiv ... Full text Link to item Cite

Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2018 Link to item Cite

Future trends in equipment

Chapter · March 28, 2018 Full text Cite

Multimodal Analgesia in Breast Surgical Procedures: Technical and Pharmacological Considerations for Liposomal Bupivacaine Use.

Journal Article Plast Reconstr Surg Glob Open · September 2017 Enhanced recovery after surgery is a multidisciplinary perioperative clinical pathway that uses evidence-based interventions to improve the patient experience as well as increase satisfaction, reduce costs, mitigate the surgical stress response, accelerate ... Full text Link to item Cite

Essentials of Our Current Understanding: Abdominal Wall Blocks.

Journal Article Reg Anesth Pain Med · 2017 Abdominal wall blocks rely on the spread of local anesthetic within musculofascial planes to anesthetize multiple small nerves or plexuses, rather than targeting specific nerve structures. Ultrasonography is primarily responsible for the widespread adoptio ... Full text Link to item Cite

Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.

Journal Article Front Syst Neurosci · 2017 Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality of life, early retirement, incr ... Full text Open Access Link to item Cite

Enhanced Recovery for Orthopedic Surgery.

Journal Article Int Anesthesiol Clin · 2017 Full text Link to item Cite

Pectoral Fascial (PECS) I and II Blocks as Rescue Analgesia in a Patient Undergoing Minimally Invasive Cardiac Surgery.

Journal Article Reg Anesth Pain Med · 2017 INTRODUCTION: Patients undergoing minimally invasive cardiac surgery have the potential for significant pain from the thoracotomy site. We report the successful use of pectoral nerve block types I and II (Pecs I and II) as rescue analgesia in a patient und ... Full text Link to item Cite

Peripheral nerve blocks in the management of postoperative pain: challenges and opportunities.

Journal Article J Clin Anesth · December 2016 Peripheral nerve blocks (PNBs) are increasingly used as a component of multimodal analgesia and may be administered as a single injection (sPNB) or continuous infusion via a perineural catheter (cPNB). We undertook a qualitative review focusing on sPNB and ... Full text Open Access Link to item Cite

High Opening Injection Pressure Is Associated With Needle-Nerve and Needle-Fascia Contact During Femoral Nerve Block.

Journal Article Reg Anesth Pain Med · 2016 BACKGROUND AND OBJECTIVES: High opening injection pressures (OIPs) have been shown to predict sustained needle tip contact with the roots of the brachial plexus. Such roots have a uniquely high ratio of fascicular versus connective tissue. It is unknown if ... Full text Link to item Cite

Time to Analgesia Onset and Pharmacokinetics After Separate and Combined Administration of Liposome Bupivacaine and Bupivacaine HCl: Considerations for Clinicians.

Journal Article Open Orthop J · 2016 BACKGROUND: Liposome bupivacaine is a prolonged-release bupivacaine formulation indicated for single-dose administration into the surgical site to produce postsurgical analgesia. METHODS: An overview of time to onset of analgesia observed with liposome bup ... Full text Open Access Link to item Cite

Injection pressure monitoring: no more excuses.

Journal Article J Clin Monit Comput · December 2015 Full text Link to item Cite

Evaluation of the eZono 4000 with eZGuide for ultrasound-guided procedures.

Journal Article Expert Rev Med Devices · May 2015 Ultrasound-guided procedures are increasingly common in a variety of acute care settings, such as the operating room, critical care unit and emergency room. However, accurate judgment of needle tip position using traditional ultrasound technology is freque ... Full text Link to item Cite

Regional anesthesia for the trauma patient: improving patient outcomes.

Journal Article Local Reg Anesth · 2015 Trauma is a significant health problem and a leading cause of death in all age groups. Pain related to trauma is frequently severe, but is often undertreated in the trauma population. Opioids are widely used to treat pain in injured patients but have a bro ... Full text Open Access Link to item Cite

Evolution of transversus abdominis plane infiltration techniques for postsurgical analgesia following abdominal surgeries.

Journal Article Local Reg Anesth · 2015 Transversus abdominis plane (TAP) infiltration is a regional anesthesia technique that has been demonstrated to be effective for management of postsurgical pain after abdominal surgery. There are several different clinical variations in the approaches used ... Full text Open Access Link to item Cite

Anesthesia considerations for musculoskeletal trauma

Chapter · January 1, 2015 Objectives Review the anesthetic considerations for complex musculoskeletal injuries including pelvic and long-bone fractures, traumatic amputations, and crush syndrome. Discuss issues related to the timing of surgical fixation of specific fractures. Discu ... Full text Cite

Opening injection pressure consistently detects needle-nerve contact during ultrasound-guided interscalene brachial plexus block.

Journal Article Anesthesiology · May 2014 BACKGROUND: Needle trauma may cause neuropathy after nerve blockade. Even without injection, nerve injury can result from forceful needle-nerve contact (NNC). High opening injection pressures (OIPs) have been associated with intrafascicular needle tip plac ... Full text Link to item Cite

Total ankle arthroplasty and perioperative pain.

Journal Article J Surg Orthop Adv · 2014 Total ankle arthroplasty is a procedure that has been shown to greatly improve patient quality of life. However, it is associated with moderate to severe postoperative pain. Commonly used strategies for pain control include opioids, multimodal analgesia wi ... Link to item Cite

Reply to Drs Egeler, Jayakumar, and Ford.

Journal Article Reg Anesth Pain Med · 2014 Full text Link to item Cite

Preface

Journal Article Methods in Molecular Biology · September 20, 2013 Cite

Regional anesthesia for trauma outside the operating theatre.

Journal Article Curr Opin Anaesthesiol · August 2013 PURPOSE OF REVIEW: Pain management in the trauma patient can be challenging, especially outside the operating room setting. Traditional analgesics such as opioids and NSAIDs are also problematic in trauma care. In this review, the use of regional anestheti ... Full text Link to item Cite

Reply to Drs Rowley and Emamdee.

Journal Article Reg Anesth Pain Med · 2013 Full text Link to item Cite

The effects of ultrasound-guided adductor canal block versus femoral nerve block on quadriceps strength and fall risk: a blinded, randomized trial of volunteers.

Journal Article Reg Anesth Pain Med · 2013 BACKGROUND AND OBJECTIVES: Adductor canal block (ACB) has been suggested as an analgesic alternative to femoral nerve block (FNB) for procedures on the knee, but its effect on quadriceps motor function is unclear. We performed a randomized, blinded study t ... Full text Link to item Cite

Fascia lliaca block for analgesia after hip arthroplasty: a randomized double-blind, placebo-controlled trial.

Journal Article Reg Anesth Pain Med · 2013 BACKGROUND AND OBJECTIVES: Fascia iliaca block (FIB) is often used to treat pain after total hip arthroplasty (THA), despite a lack of randomized trials to evaluate its efficacy for this indication. The objective of this study was to assess the analgesic b ... Full text Link to item Cite

Regional anesthesia for burns

Chapter · November 12, 2012 Full text Cite

Prehospital regional anesthesia

Chapter · November 12, 2012 Full text Cite

Introduction to pain management

Chapter · October 16, 2012 Cite

The sequence of administration of 1.5% mepivacaine and 0.5% bupivacaine does not affect latency of block onset or duration of analgesia in ultrasound-guided interscalene block.

Journal Article Anesth Analg · October 2012 BACKGROUND: During peripheral nerve blockade, different local anesthetics may be sequentially administered. Typically, a short- or intermediate-acting local anesthetic is administered before a long-acting local anesthetic to achieve a block with rapid onse ... Full text Link to item Cite

Regional anesthesia in trauma: A case-based approach

Book · January 1, 2012 The management of pain from acute injuries is a priority in trauma care. Regional analgesic techniques are very effective at treating acute pain and are gaining in popularity as recognition of their beneficial effects on morbidity increases. Regional Anest ... Full text Cite

Monitoring for regional anesthesia

Chapter · January 1, 2012 General anesthesia has become increasingly safe over the last two decades, largely due to improvements in monitoring such as pulse oximetry and capnography [1]. These technologies, which allow for early detection of potentially catastrophic adverse events ... Full text Cite

The effect of stimulating versus conventional perineural catheters on postoperative analgesia following ultrasound-guided femoral nerve localization.

Journal Article J Clin Anesth · December 2011 STUDY OBJECTIVE: To test the hypothesis that, if the femoral nerve is correctly localized using ultrasound (US) guidance, the type of perineural catheter used has no effect on catheter success. DESIGN: Randomized controlled trial. SETTING: Post-anesthesia ... Full text Link to item Cite

Anesthesiology Oral Board Flash Cards

Book · September 15, 2011 Cite

The effect of mixing 1.5% mepivacaine and 0.5% bupivacaine on duration of analgesia and latency of block onset in ultrasound-guided interscalene block.

Journal Article Anesth Analg · February 2011 BACKGROUND: Short- and long-acting local anesthetics are commonly mixed to achieve nerve blocks with short onset and long duration. However, there is a paucity of data on advantages of such mixtures. We hypothesized that a mixture of mepivacaine and bupiva ... Full text Link to item Cite

Monitoring during peripheral nerve blockade.

Journal Article Curr Opin Anaesthesiol · October 2010 PURPOSE OF REVIEW: Objective monitors to warn against adverse events specific to the performance of nerve blockade are relatively unsophisticated compared with monitors used during general anesthesia. The purpose of this review is to outline the various mo ... Full text Link to item Cite

Do residency applicants know what the ACGME core competencies are? One program's experience.

Journal Article Acad Med · May 2010 PURPOSE: To determine the degree of knowledge that medical students applying to the St. Luke's-Roosevelt Hospital Center anesthesiology residency program had regarding the core physician competencies mandated by the Accreditation Council for Graduate Medic ... Full text Link to item Cite

Reply

Journal Article Journal of Clinical Anesthesia · March 1, 2010 Full text Cite

Intraneural injection with low-current stimulation during popliteal sciatic nerve block.

Journal Article Anesth Analg · August 2009 BACKGROUND: Prevention of an intraneural injection of a local anesthetic during peripheral nerve blockade is considered important to avoid neurologic injury. However, the needle-nerve relationship during low-current electrical nerve localization is not wel ... Full text Link to item Cite

Low interscalene block provides reliable anesthesia for surgery at or about the elbow.

Journal Article J Clin Anesth · March 2009 STUDY OBJECTIVE: To determine whether interscalene brachial plexus block (ISB) provides adequate anesthesia for surgery on or about the elbow. STUDY DESIGN: Case series. SETTING: Operating room of an academic teaching hospital. PATIENTS: 78 patients schedu ... Full text Link to item Cite

Blocks in anesthetized patients.

Journal Article Reg Anesth Pain Med · 2009 Full text Link to item Cite

Lumbar plexus or lumbar paravertebral blocks?

Journal Article Anesthesiology · January 1, 2009 Full text Cite

Lumbar plexus block using high-pressure injection leads to contralateral and epidural spread.

Journal Article Anesthesiology · October 2008 BACKGROUND: The main advantage of lumbar plexus block over neuraxial anesthesia is unilateral blockade; however, the relatively common occurrence of bilateral spread (up to 27%) makes this advantage unpredictable. The authors hypothesized that high injecti ... Full text Link to item Cite

Post-cesarean delivery analgesia.

Journal Article Anesth Analg · November 2005 Post-cesarean delivery pain relief is important. Good pain relief will improve mobility and can reduce the risk of thromboembolic disease, which is increased during pregnancy. Pain may also impair the mother's ability to optimally care for her infant in th ... Full text Link to item Cite

A survey of orthopedic surgeons' attitudes and knowledge regarding regional anesthesia.

Journal Article Anesth Analg · May 2004 UNLABELLED: We conducted a survey to explore the surgical attitudes and preferences regarding regional anesthesia among Canadian orthopedic surgeons. Surveys were returned by 468 (61%) of 768 surgeons. Forty-eight percent of respondents directed their pati ... Full text Link to item Cite

Acute upper airway angioedema secondary to acquired C1 esterase inhibitor deficiency: a case report.

Journal Article Can J Anaesth · November 2003 PURPOSE: Adverse reactions to local anesthetics are widely reported. We report a case of acute upper airway angioedema presumed to be due to the local anesthetic articaine, which was subsequently diagnosed as acquired C1 esterase inhibitor deficiency. CLIN ... Full text Link to item Cite