Scholars@Duke
Jennifer K Plichta

Jennifer K Plichta

Associate Professor of Surgery
Surgical Oncology
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Selected Publications

Demographics and Clinical Decision Making in Patients with Germline Moderate Penetrance Non-BRCA Mutations in Breast Cancer Related Genes.

Journal Article Ann Surg Oncol · October 2024 BACKGROUND: Management of pathogenic variants in high penetrance genes related to breast cancer (BC), such as BRCA1 and BRCA2, are well established. However, moderate penetrance mutations are understudied. We aim to compare risk reduction decision-making p ... Full text Link to item Cite

Utility of Axillary Staging in Older Patients with HER2-Positive Breast Cancer.

Journal Article Ann Surg Oncol · October 2024 BACKGROUND: The utility of sentinel lymph node biopsy (SLNB) in older patients remains controversial. Advancements in human epidermal growth factor receptor 2 (HER2)-directed therapy have revolutionized disease response rates and prognosis, supporting effo ... Full text Link to item Cite

Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia.

Journal Article Ann Surg Oncol · October 2024 BACKGROUND: Proliferative breast atypical lesions, including atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), represent benign entities that confer an elevated risk of ductal carcinoma in situ (DCIS) and invasive breast cancer ... Full text Link to item Cite

Germline genetic mutations in a multi-center cohort of 248 phyllodes tumors.

Journal Article Breast Cancer Res Treat · September 13, 2024 PURPOSE: Germline genetic mutations in women with phyllodes tumors (PT) are understudied, although some describe associations of PT with various mutations. We sought to determine the prevalence of pathogenic/likely pathogenic (P/LP) variants in women with ... Full text Link to item Cite

Omission of Axillary Lymph Node Dissection in Patients with Residual Nodal Disease After Neoadjuvant Chemotherapy.

Conference Ann Surg Oncol · September 4, 2024 BACKGROUND: Axillary management after neoadjuvant chemotherapy (NAC) is evolving but axillary lymph node dissection (ALND) remains the standard of care for patients with residual nodal disease. The results of the Alliance A011202 trial evaluating the oncol ... Full text Link to item Cite

Surgical Perspectives on the Updated ASTRO Guideline on Partial Breast Irradiation for Breast Cancer.

Journal Article Ann Surg Oncol · September 2024 This is an executive summary of the most recent American Society for Radiation Oncology (ASTRO) guidelines on use of partial breast irradiation in early-stage breast cancer.In the conscientious pursuit of "right-sizing" the management of patients with earl ... Full text Link to item Cite

Triple-Negative Breast Cancer in Older Patients: Does SLNB Guide Therapy?

Journal Article Ann Surg Oncol · August 28, 2024 BACKGROUND: Older breast cancer patients represent a heterogeneous population. Studies demonstrate that sentinel lymph node biopsy (SLNB) omission may be appropriate in some clinical scenarios, yet patients with triple-negative breast cancer (TNBC) are oft ... Full text Link to item Cite

Rates of Pathologic Complete Response and Overall Survival in Patients with Inflammatory Breast Cancer: A National Cancer Database Study.

Conference Ann Surg Oncol · August 19, 2024 BACKGROUND: Patients with inflammatory breast cancer (IBC) have worse survival compared with stage III non-IBC matched cohorts; however, the prognostic significance of achieving pathologic complete response (pCR) in the setting of IBC is not well described ... Full text Link to item Cite

Comparison of incident breast cancer cases in the largest national US tumor registries.

Conference Cancer · August 18, 2024 BACKGROUND: This study compared incident breast cancer cases in the National Cancer Database (NCDB) and Surveillance, Epidemiology, End Results Program (SEER) to a national population cancer registry. METHODS: Patients with malignant or in situ breast canc ... Full text Link to item Cite

Assessment of Treatment Sequence in Patients With Stage III Breast Cancer.

Journal Article J Surg Res · August 14, 2024 INTRODUCTION: Stage III breast cancer is defined as locally advanced breast cancer and is treated with curative intent. Historically, overall survival (OS) did not differ based on treatment sequence (neoadjuvant chemotherapy [NAC] followed by surgery versu ... Full text Link to item Cite

Axillary nodal disease burden is not associated with an elevated 21-gene recurrence score in post-menopausal women presenting with a clinically negative axilla.

Journal Article Am J Surg · July 2024 BACKGROUND: The predictive and prognostic value of the recurrence score (RS) has emphasized the importance of tumor biology and has reduced the prognostic implications of limited nodal burden in post-menopausal women with HR+/HER2-invasive breast cancer (I ... Full text Link to item Cite

Clinical genetics in breast cancer.

Journal Article J Surg Oncol · July 2024 As genetic testing becomes increasingly more accessible and more applicable with a broader range of clinical implications, it may also become more challenging for breast cancer providers to remain up-to-date. This review outlines some of the current clinic ... Full text Link to item Cite

Clinical efficacy of CDK4/6 inhibitor plus endocrine therapy in HR-positive/HER2-0 and HER2-low-positive metastatic breast cancer: a secondary analysis of PALOMA-2 and PALOMA-3 trials.

Journal Article EBioMedicine · July 2024 BACKGROUND: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors in combination with traditional endocrine therapy (ET) are now the recommended first-line treatment for hormone receptor (HR)-positive and HER2-negative metastatic breast cancer (MBC). However, th ... Full text Link to item Cite

Demographics and Clinical Decision Making in Patients with Germline Moderate Penetrance Non-BRCA Mutations in Breast Cancer Related Genes.

Journal Article Ann Surg Oncol · October 2024 BACKGROUND: Management of pathogenic variants in high penetrance genes related to breast cancer (BC), such as BRCA1 and BRCA2, are well established. However, moderate penetrance mutations are understudied. We aim to compare risk reduction decision-making p ... Full text Link to item Cite

Utility of Axillary Staging in Older Patients with HER2-Positive Breast Cancer.

Journal Article Ann Surg Oncol · October 2024 BACKGROUND: The utility of sentinel lymph node biopsy (SLNB) in older patients remains controversial. Advancements in human epidermal growth factor receptor 2 (HER2)-directed therapy have revolutionized disease response rates and prognosis, supporting effo ... Full text Link to item Cite

Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia.

Journal Article Ann Surg Oncol · October 2024 BACKGROUND: Proliferative breast atypical lesions, including atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), represent benign entities that confer an elevated risk of ductal carcinoma in situ (DCIS) and invasive breast cancer ... Full text Link to item Cite

Germline genetic mutations in a multi-center cohort of 248 phyllodes tumors.

Journal Article Breast Cancer Res Treat · September 13, 2024 PURPOSE: Germline genetic mutations in women with phyllodes tumors (PT) are understudied, although some describe associations of PT with various mutations. We sought to determine the prevalence of pathogenic/likely pathogenic (P/LP) variants in women with ... Full text Link to item Cite

Omission of Axillary Lymph Node Dissection in Patients with Residual Nodal Disease After Neoadjuvant Chemotherapy.

Conference Ann Surg Oncol · September 4, 2024 BACKGROUND: Axillary management after neoadjuvant chemotherapy (NAC) is evolving but axillary lymph node dissection (ALND) remains the standard of care for patients with residual nodal disease. The results of the Alliance A011202 trial evaluating the oncol ... Full text Link to item Cite

Surgical Perspectives on the Updated ASTRO Guideline on Partial Breast Irradiation for Breast Cancer.

Journal Article Ann Surg Oncol · September 2024 This is an executive summary of the most recent American Society for Radiation Oncology (ASTRO) guidelines on use of partial breast irradiation in early-stage breast cancer.In the conscientious pursuit of "right-sizing" the management of patients with earl ... Full text Link to item Cite

Triple-Negative Breast Cancer in Older Patients: Does SLNB Guide Therapy?

Journal Article Ann Surg Oncol · August 28, 2024 BACKGROUND: Older breast cancer patients represent a heterogeneous population. Studies demonstrate that sentinel lymph node biopsy (SLNB) omission may be appropriate in some clinical scenarios, yet patients with triple-negative breast cancer (TNBC) are oft ... Full text Link to item Cite

Rates of Pathologic Complete Response and Overall Survival in Patients with Inflammatory Breast Cancer: A National Cancer Database Study.

Conference Ann Surg Oncol · August 19, 2024 BACKGROUND: Patients with inflammatory breast cancer (IBC) have worse survival compared with stage III non-IBC matched cohorts; however, the prognostic significance of achieving pathologic complete response (pCR) in the setting of IBC is not well described ... Full text Link to item Cite

Comparison of incident breast cancer cases in the largest national US tumor registries.

Conference Cancer · August 18, 2024 BACKGROUND: This study compared incident breast cancer cases in the National Cancer Database (NCDB) and Surveillance, Epidemiology, End Results Program (SEER) to a national population cancer registry. METHODS: Patients with malignant or in situ breast canc ... Full text Link to item Cite

Assessment of Treatment Sequence in Patients With Stage III Breast Cancer.

Journal Article J Surg Res · August 14, 2024 INTRODUCTION: Stage III breast cancer is defined as locally advanced breast cancer and is treated with curative intent. Historically, overall survival (OS) did not differ based on treatment sequence (neoadjuvant chemotherapy [NAC] followed by surgery versu ... Full text Link to item Cite

Axillary nodal disease burden is not associated with an elevated 21-gene recurrence score in post-menopausal women presenting with a clinically negative axilla.

Journal Article Am J Surg · July 2024 BACKGROUND: The predictive and prognostic value of the recurrence score (RS) has emphasized the importance of tumor biology and has reduced the prognostic implications of limited nodal burden in post-menopausal women with HR+/HER2-invasive breast cancer (I ... Full text Link to item Cite

Clinical genetics in breast cancer.

Journal Article J Surg Oncol · July 2024 As genetic testing becomes increasingly more accessible and more applicable with a broader range of clinical implications, it may also become more challenging for breast cancer providers to remain up-to-date. This review outlines some of the current clinic ... Full text Link to item Cite

Clinical efficacy of CDK4/6 inhibitor plus endocrine therapy in HR-positive/HER2-0 and HER2-low-positive metastatic breast cancer: a secondary analysis of PALOMA-2 and PALOMA-3 trials.

Journal Article EBioMedicine · July 2024 BACKGROUND: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors in combination with traditional endocrine therapy (ET) are now the recommended first-line treatment for hormone receptor (HR)-positive and HER2-negative metastatic breast cancer (MBC). However, th ... Full text Link to item Cite

Survival among patients with untreated metastatic breast cancer: "What if I do nothing?".

Journal Article Breast Cancer Res Treat · June 2024 PURPOSE: We sought to assess survival outcomes of patients with de novo metastatic breast cancer (dnMBC) who did not receive treatment irrespective of the reason. METHODS: Adults with dnMBC were selected from the NCDB (2010-2016) and stratified based on re ... Full text Link to item Cite

Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy.

Journal Article J Clin Oncol · May 10, 2024 PURPOSE: Black women have higher rates of death from triple-negative breast cancer (TNBC) than White women. We hypothesized that pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) may vary by race/ethnicity in pa ... Full text Link to item Cite

Society of Surgical Oncology Breast Disease Site Working Group Statement on Contralateral Mastectomy: Indications, Outcomes, and Risks.

Journal Article Ann Surg Oncol · April 2024 Rates of contralateral mastectomy (CM) among patients with unilateral breast cancer have been increasing in the United States. In this Society of Surgical Oncology position statement, we review the literature addressing the indications, risks, and benefits ... Full text Link to item Cite

Anatomy Versus Biology: What Guides Chemotherapy Decisions in Older Patients With Breast Cancer?

Journal Article J Surg Res · April 2024 INTRODUCTION: With the increasing utilization of genomic assays, such as the Oncotype DX recurrence score (RS), the relevance of anatomic staging has been questioned for select older patients with breast cancer. We sought to evaluate differences in chemoth ... Full text Link to item Cite

Digital Health Platforms for Breast Cancer Care: A Scoping Review.

Journal Article J Clin Med · March 27, 2024 Breast cancer is a significant global health concern affecting millions of women each year. Digital health platforms are an easily accessible intervention that can improve patient care, though their efficacy in breast cancer care is unknown. This scoping r ... Full text Link to item Cite

Germline Testing in Patients With Breast Cancer: ASCO-Society of Surgical Oncology Guideline.

Journal Article J Clin Oncol · February 10, 2024 PURPOSE: To develop recommendations for germline mutation testing for patients with breast cancer. METHODS: An ASCO-Society of Surgical Oncology (SSO) panel convened to develop recommendations based on a systematic review and formal consensus process. RESU ... Full text Link to item Cite

Implementation of a novel peer review academy by Surgery and the Association of Women Surgeons.

Journal Article Surgery · February 2024 BACKGROUND: A novel Peer Review Academy was developed as a collaborative effort between the Association of Women Surgeons and the journal Surgery to provide formal training in peer review. We aimed to describe the outcomes of this initiative using a mixed ... Full text Link to item Cite

Impact of HER2-low status for patients with early-stage breast cancer and non-pCR after neoadjuvant chemotherapy: a National Cancer Database Analysis.

Journal Article Breast Cancer Res Treat · February 2024 PURPOSE: To investigate potential differences in pathological complete response (pCR) rates and overall survival (OS) between HER2-low and HER2-zero patients with early-stage hormone receptor (HR)-positive and triple-negative breast cancer (TNBC), in the n ... Full text Open Access Link to item Cite

BRCA1/2 mutation carriers & risk reducing mastectomy: Who undergoes surgery and potential benefits.

Journal Article Am J Surg · January 2024 BACKGROUND: Risk-reducing mastectomy (RRM) is the most effective breast cancer risk-reduction strategy in BRCA1/2 mutation carriers. We examined factors associated with RRM and its relationship with overall survival (OS). METHODS: Patients aged 18-80y at d ... Full text Link to item Cite

Germline Genetic Testing for Patients with Breast Atypia

Conference ANNALS OF SURGICAL ONCOLOGY · 2024 Cite

Immune Phenotype and Postoperative Complications After Elective Surgery.

Journal Article Ann Surg · December 1, 2023 OBJECTIVES: To characterize and quantify accumulating immunologic alterations, pre and postoperatively in patients undergoing elective surgical procedures. BACKGROUND: Elective surgery is an anticipatable, controlled human injury. Although the human respon ... Full text Link to item Cite

Breast Cancer Risk Assessment and Screening Practices Reported Via an Online Survey.

Journal Article Annals of surgical oncology · October 2023 BackgroundBreast cancer screening guidelines differ between organizations, and significant variations in practice patterns exist. Previous evidence suggests that provider-level factors are the greatest contributors to risk assessment and screening ... Full text Cite

Neoadjuvant Chemotherapy and Endocrine Therapy for Older Patients with Estrogen Receptor Positive Breast Cancer: Comparison of Approaches.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Benefits of a pathologic complete response (pCR) following neoadjuvant therapy are well established, yet outcomes for older women are understudied. We sought to examine the pCR and overall survival (OS) rates of women with estrogen receptor (ER ... Full text Link to item Cite

Contralateral Prophylactic Mastectomy Decision-Making: The Partners' Perspective.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: The rate of contralateral prophylactic mastectomy (CPM) continues to rise despite no improvement in survival, an increased risk of surgical complications, and negative effects on quality of life. This study explored the experiences of the partn ... Full text Link to item Cite

NCCN Guidelines® Insights: Breast Cancer Screening and Diagnosis, Version 1.2023.

Journal Article J Natl Compr Canc Netw · September 2023 The NCCN Guidelines for Breast Cancer Screening and Diagnosis provide health care providers with a practical, consistent framework for screening and evaluating a spectrum of clinical presentations and breast lesions. The NCCN Breast Cancer Screening and Di ... Full text Link to item Cite

Prognostic Tools for Older Women with Breast Cancer: A Systematic Review.

Journal Article Medicina (Kaunas) · August 30, 2023 Background: Breast cancer is the most common cancer in women, and older patients comprise an increasing proportion of patients with this disease. The older breast cancer population is heterogenous with unique factors affecting clinical decision making. Whi ... Full text Link to item Cite

Novel Prognostic Staging System for Patients With De Novo Metastatic Breast Cancer.

Journal Article J Clin Oncol · May 10, 2023 PURPOSE: Given the heterogeneity and improvement in outcomes for metastatic breast cancer (MBC), we developed a staging system that refines prognostic estimates for patients with metastatic cancer at the time of initial diagnosis, de novo MBC (dnMBC), on t ... Full text Link to item Cite

Survival Benefit of Chemotherapy According to 21-Gene Recurrence Score in Young Women with Breast Cancer.

Journal Article Ann Surg Oncol · April 2023 BACKGROUND: Initial trials evaluating Oncotype DX, reported as a recurrence score (RS) from 0 to 100, were not powered to evaluate overall survival, and premenopausal women were underrepresented. The purpose of this study was to explore the benefit of chem ... Full text Link to item Cite

Risk factors for persistent pain after breast cancer surgery: a multicentre prospective cohort study.

Journal Article Anaesthesia · April 2023 Identifying factors associated with persistent pain after breast cancer surgery may facilitate risk stratification and individualised management. Single-population studies have limited generalisability as socio-economic and genetic factors contribute to pe ... Full text Link to item Cite

Surgery in the Setting of Metastatic Breast Cancer

Journal Article Current Breast Cancer Reports · March 1, 2023 Purpose of Review: Among individuals with metastatic breast cancer, surgical resection of the primary tumor remains controversial, and its benefit is unclear. In this review, we highlight select retrospective and prospective studies which have sought to ad ... Full text Cite

Abstract P3-05-20: Low 21-Gene Recurrence Score Is Not Associated with a High Axillary Nodal Burden in Post-Menopausal Women Presenting with a Clinically Negative Axilla

Conference Cancer Research · March 1, 2023 AbstractBackground: The predictive and prognostic value of the 21-gene recurrence score (RS) has emphasized the importance of tumor biology and minimized the credence of a limited (1-3 positive) nodal burden ... Full text Cite

Abstract P1-06-02: The effect of race on pathologic complete response rates and overall survival in patients with triple negative breast cancer

Conference Cancer Research · March 1, 2023 AbstractIntroduction: Despite the recent overall improvement in survival for patients with breast cancer, racial disparities in outcomes persist. While studies have demonstrated that socioeconomic factors an ... Full text Cite

Genetics of Breast Cancer: Risk Models, Who to Test, and Management Options.

Journal Article Surg Clin North Am · February 2023 Genetic testing plays an important role in assessing breast cancer risk and often the risk of other types of cancers. Accurate risk assessment and stratification represents a critical element of identifying who is best served by increased surveillance and ... Full text Link to item Cite

Concordance Between Genomic Alterations Detected by Tumor and Germline Sequencing: Results from a Tertiary Care Academic Center Molecular Tumor Board.

Journal Article Oncologist · January 18, 2023 OBJECTIVE: The majority of tumor sequencing currently performed on cancer patients does not include a matched normal control, and in cases where germline testing is performed, it is usually run independently of tumor testing. The rates of concordance betwe ... Full text Open Access Link to item Cite

The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

Conference Am J Surg · January 2023 BACKGROUND: We investigated whether tumor phenotype influences surgical decision-making, and how that may impact overall survival (OS) for early-stage breast cancer. METHODS: Women aged 18-69 with cT0-2/cN0/cM0 breast cancer in the National Cancer Database ... Full text Link to item Cite

Implications of missing data on reported breast cancer mortality.

Journal Article Breast Cancer Res Treat · January 2023 BACKGROUND: National cancer registries are valuable tools to analyze patterns of care and clinical outcomes; yet, missing data may impact the accuracy and generalizability of these data. We sought to evaluate the association between missing data and overal ... Full text Open Access Link to item Cite

Changing Demographics in Young Women with Breast Cancer Suggest Improved Access to Screening

Conference JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS · 2023 Cite

ShouldStage IA Breast Cancerbe Expanded?

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

High Risk Screening in Women with BRCA1/2 Mutations Age 70 and Above

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

The art of peer review: Guidelines to become a credible and constructive peer reviewer.

Journal Article Semin Vasc Surg · December 2022 Peer review is a learned skill set that requires knowledge of study design, review construct, ethical considerations, and general expertise in a field of study. Participating in peer review is a rewarding and valuable experience in which all academic physi ... Full text Link to item Cite

The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions.

Conference Ann Surg Oncol · October 2022 BACKGROUND: Multiple studies have demonstrated a link between obesity and breast cancer; however, the potential association between obesity and atypical high-risk breast lesions has not been well characterized. We sought to evaluate the characteristics and ... Full text Link to item Cite

Surgical Treatment of de novo Metastatic Breast Cancer

Journal Article Current Breast Cancer Reports · September 1, 2022 Purpose of review: De novo metastatic breast cancer (dnMBC) accounts for approximately 6% of all new breast cancers each year. While the survival benefits from removing the primary tumor in patients with MBC remain unclear, many patients still undergo surg ... Full text Cite

Design and Evaluation of a Computational Phenotype to Identify Patients With Metastatic Breast Cancer Within the Electronic Health Record.

Journal Article JCO Clin Cancer Inform · September 2022 PURPOSE: Outcomes for patients with metastatic breast cancer (MBC) are continually improving as more effective treatments become available. Granular data sets of this unique population are lacking, and the standard method for data collection relies largely ... Full text Link to item Cite

Which Factors Are Important to Women When Choosing a Breast Reconstruction Surgeon?

Journal Article Plast Reconstr Surg · July 1, 2022 BACKGROUND: Women undergoing breast reconstruction often research their health care provider options. The authors studied which factors may influence how a woman selects a plastic surgeon for breast reconstruction surgery. METHODS: An online survey was dis ... Full text Link to item Cite

Disparities at the Intersection of Race and Ethnicity: Examining Trends and Outcomes in Hispanic Women With Breast Cancer.

Journal Article JCO Oncol Pract · May 2022 PURPOSE: We sought to examine tumor subtype, stage at diagnosis, time to surgery (TTS), and overall survival (OS) among Hispanic patients of different races and among Hispanic and non-Hispanic (NH) women of the same race. METHODS: Women 18 years of age or ... Full text Link to item Cite

Malignant phyllodes tumor and primary breast sarcoma; distinct rare tumors of the breast.

Conference J Surg Oncol · May 2022 BACKGROUND: Malignant phyllodes (MP) and primary breast sarcomas (PBS) are rare neoplasms with overlapping histopathologic features. We compared overall survival (OS) and estimated the association of surgery and therapies with OS. METHODS: We utilized the ... Full text Link to item Cite

A Comparison of Complications in Therapeutic versus Contralateral Prophylactic Mastectomy Reconstruction: A Paired Analysis.

Journal Article Plast Reconstr Surg · May 1, 2022 BACKGROUND: Although breast reconstruction after bilateral mastectomies including a contralateral prophylactic mastectomy is known to have a higher overall complication profile, whether reconstructive complication rates differ between the therapeutic maste ... Full text Link to item Cite

A Novel Staging System for De Novo Metastatic Breast Cancer Refines Prognostic Estimates.

Journal Article Ann Surg · April 1, 2022 OBJECTIVE: We aim to identify prognostic groups within a de novo metastatic cohort, incorporating both anatomic and biologic factors. BACKGROUND: Staging for breast cancer now includes anatomic and biologic factors, although the guidelines for stage IV dis ... Full text Link to item Cite

Disease characteristics and mortality among Asian women with breast cancer.

Conference Cancer · March 1, 2022 BACKGROUND: Asian women with breast cancer are often studied in aggregate, belying significant intragroup diversity. The authors sought to examine differences in breast cancer characteristics and outcomes among Asian women. METHODS: Asian, non-Hispanic Bla ... Full text Link to item Cite

Utilization of neoadjuvant chemotherapy in high-risk, node-negative early breast cancer.

Journal Article Cancer Med · February 2022 BACKGROUND: Controversy exists regarding the optimal sequence of chemotherapy among women with operable node-negative breast cancers with high-risk tumor biology. We evaluated national patterns of neoadjuvant chemotherapy (NACT) use among women with early- ... Full text Link to item Cite

Metastatic breast cancer: Who benefits from surgery?

Journal Article Am J Surg · January 2022 BACKGROUND: We sought to identify characteristics of metastatic breast cancer (MBC) patients who may benefit most from primary tumor resection. METHODS: Recursive partitioning analysis (RPA) was used to categorize non-surgical patients with de novo MBC in ... Full text Link to item Cite

Disparities in Genetic Testing for Heritable Solid-Tumor Malignancies.

Journal Article Surg Oncol Clin N Am · January 2022 Genetic testing offers providers a potentially life saving tool for identifying and intervening in high-risk individuals. However, disparities in receipt of genetic testing have been consistently demonstrated and undoubtedly have significant implications f ... Full text Link to item Cite

Genetic Counseling and Testing in African American Patients With Breast Cancer: A Nationwide Survey of US Breast Oncologists.

Journal Article J Clin Oncol · December 20, 2021 PURPOSE: To determine if physicians' self-reported knowledge, attitudes, and practices regarding genetic counseling and testing (GCT) vary by patients' race. METHODS: We conducted a nationwide 49-item survey among breast oncology physicians in the United S ... Full text Link to item Cite

Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.

Journal Article Br J Surg · December 1, 2021 BACKGROUND: This study aimed to determine the impact of pulmonary complications on death after surgery both before and during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. METHODS: This was a patient-level, comparative analysis ... Full text Link to item Cite

Survival Outcomes Among Patients with Metastatic Breast Cancer: Review of 47,000 Patients.

Conference Ann Surg Oncol · November 2021 BACKGROUND: Although metastatic breast cancer (MBC) remains incurable, advances in therapies have improved survival. Using a contemporary dataset of de novo MBC patients, we explore how overall (OS) and cancer-specific survival (CSS) changed over time. MET ... Full text Link to item Cite

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.

Journal Article Lancet Oncol · November 2021 BACKGROUND: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during ... Full text Link to item Cite

Mortality in Older Patients with Breast Cancer Undergoing Breast Surgery: How Low is "Low Risk"?

Conference Ann Surg Oncol · October 2021 BACKGROUND: Breast surgery carries a low risk of postoperative mortality. For older patients with multiple comorbidities, even low-risk procedures can confer some increased perioperative risk. We sought to identify factors associated with postoperative mor ... Full text Link to item Cite

Contralateral Axillary Nodal Metastases: Stage IV Disease or a Manifestation of Progressive Locally Advanced Breast Cancer?

Conference Ann Surg Oncol · October 2021 BACKGROUND: Contralateral axillary nodal metastases (CAM) is classified as stage IV disease, although many centers treat CAM with curative intent. We hypothesized that patients with CAM, treated with multimodality therapy, would have improved overall survi ... Full text Link to item Cite

Mobile Health Application for Patients Undergoing Breast Cancer Surgery: Feasibility Study.

Journal Article JCO Oncol Pract · September 2021 PURPOSE: Contemporary breast cancer surgery often requires hospital stays of 1 day or less, presenting challenges to delivery of high-quality care. Without sufficient time for proper education and guidance, patients may delay seeking care, experience anxie ... Full text Link to item Cite

Characterizing participants in the North Carolina Breast and Cervical Cancer Control Program: A retrospective review of 90,000 women.

Conference Cancer · July 15, 2021 BACKGROUND: The North Carolina Breast and Cervical Cancer Control Program (NC BCCCP) provides breast cancer screening services to underserved women to mitigate disparities in access to care. The authors sought to characterize this understudied population. ... Full text Link to item Cite

Survival among patients with untreated metastatic breast cancer.

Conference Journal of Clinical Oncology · May 20, 2021 1095 Background: Treatments for metastatic breast cancer (MBC) have significantly improved survival for patients who receive treatment, yet data describing the prognosis for untreated patients is lacking. Therefore, we sought to ... Full text Cite

Treatment Patterns and Outcomes of Women with Breast Cancer and Supraclavicular Nodal Metastases.

Journal Article Ann Surg Oncol · April 2021 BACKGROUND: In 2002, breast cancer patients with supraclavicular nodal metastases (cN3c) were downstaged from AJCC stage IV to IIIc, prompting management with locoregional treatment. We sought to estimate the impact of multimodal therapy on overall surviva ... Full text Link to item Cite

Time to surgery among women treated with neoadjuvant systemic therapy and upfront surgery for breast cancer.

Journal Article Breast Cancer Res Treat · April 2021 PURPOSE: Time to surgery (TTS) is a potentially modifiable factor associated with survival after breast cancer diagnosis and can serve as a proxy for quality of oncologic care coordination. We sought to determine whether factors associated with delays in T ... Full text Link to item Cite

Pretransplant solid organ malignancy and organ transplant candidacy: A consensus expert opinion statement.

Journal Article Am J Transplant · February 2021 Patients undergoing evaluation for solid organ transplantation (SOT) often have a history of malignancy. Although the cancer has been treated in these patients, the benefits of transplantation need to be balanced against the risk of tumor recurrence, espec ... Full text Link to item Cite

Preexisting melanoma and hematological malignancies, prognosis, and timing to solid organ transplantation: A consensus expert opinion statement.

Journal Article Am J Transplant · February 2021 Patients undergoing evaluation for solid organ transplantation (SOT) frequently have a history of malignancy. Only patients with treated cancer are considered for SOT but the benefits of transplantation need to be balanced against the risk of tumor recurre ... Full text Link to item Cite

Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.

Journal Article The British journal of surgery · January 2021 BackgroundSurgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective can ... Full text Open Access Cite

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Journal Article J Clin Oncol · January 1, 2021 PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with ... Full text Link to item Cite

Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.

Journal Article Am J Pathol · December 2020 Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson disease. Although LRRK2-related Parkinson disease patients have a heightened risk of certain nonskin cancers, including breast cancer, it is unknown ... Full text Link to item Cite

Do Histopathology and Clinical Outcomes of Breast Atypia Vary by Race/Ethnicity?

Journal Article J Surg Res · November 2020 BACKGROUND: The clinical behavior of breast cancer varies by racial and ethnic makeup (REM), but the impact of REM on the clinical outcomes of breast atypia remains understudied. We examined the impact of REM on risk of underlying or subsequent carcinoma f ... Full text Link to item Cite

Surgery for Men with Breast Cancer: Do the Same Data Still Apply?

Journal Article Ann Surg Oncol · November 2020 BACKGROUND: Men represent a small proportion of breast cancer diagnoses, and they are often excluded from clinical trials. Current treatments are largely extrapolated from evidence in women. We compare practice patterns between men and women with breast ca ... Full text Link to item Cite

It's not you, It's me: The influence of patient and surgeon gender on patient satisfaction scores.

Journal Article Am J Surg · November 2020 BACKGROUND: Surgeons face the unique challenge of being responsible for both clinical encounters and surgical outcomes. We aim to explore how patient evaluations of surgeons may be influenced by patient and provider factors. METHODS: Patient responses from ... Full text Link to item Cite

Delaying surgery for patients with a previous SARS-CoV-2 infection.

Journal Article The British journal of surgery · November 2020 Full text Cite

Surgical Management of the Axilla in Elderly Women With Node-Positive Breast Cancer.

Journal Article J Surg Res · October 2020 BACKGROUND: Elderly women with clinically node-positive (cN+) breast cancer (BC) often have comorbidities that limit life expectancy and complicate treatment. We sought to determine whether the number of lymph nodes (LNs) retrieved among older women with n ... Full text Link to item Cite

Management of Male Breast Cancer: ASCO Guideline.

Journal Article J Clin Oncol · June 1, 2020 PURPOSE: To develop recommendations concerning the management of male breast cancer. METHODS: ASCO convened an Expert Panel to develop recommendations based on a systematic review and a formal consensus process. RESULTS: Twenty-six descriptive reports or o ... Full text Link to item Cite

A Tale of Two Sisters: Breast Reconstruction Options for Women With or at High Risk of Breast Cancer.

Journal Article J Adv Pract Oncol · March 2020 Breast reconstructive surgery has changed significantly over the past decade. The incidence of nipple-sparing procedures and prophylactic mastectomy has also increased significantly as women and their surgeons use shared decision-making strategies. The fol ... Full text Link to item Cite

Abstract P3-08-10: Characterization of oncotype DX recurrence score and chemotherapy utilization patterns in young women (≤40) with early stage ER+/HER-, lymph node negative breast cancer

Conference Cancer Research · February 15, 2020 AbstractBackground: Meta-analyses have demonstrated that young women ≤40 (YW) derive the most benefit from chemotherapy (EBCTCG, Lancet. 1998). Oncotype DX was designed to determine the benefit of chemothera ... Full text Cite

Abstract P1-21-07: The Patient-reported Outcomes after Routine Treatment of Atypical Lesions (PORTAL) study: Pain, psychosocial wellbeing, and quality of life among women undergoing guideline concordant care for DCIS vs. active surveillance for in situ and atypical lesions

Conference Cancer Research · February 15, 2020 AbstractBackground: Guideline-concordant care (GCC) for DCIS includes surgery, radiation, and endocrine treatment. Active surveillance (AS) is a strategy under study for management of low risk DCIS. The PORT ... Full text Cite

Axillary lymph node dissection in node-positive breast cancer: are ten nodes adequate and when is enough, enough?

Conference Breast Cancer Res Treat · February 2020 PURPOSE: National guidelines define adequate axillary lymph node dissections as those yielding ≥ 10 lymph nodes (LNs). We aimed to identify the optimal LN yield among node-positive patients. METHODS: Using the National Cancer Data Base (2010-2015), we cate ... Full text Link to item Cite

Breast cancer tumor histopathology, stage at presentation, and treatment in the extremes of age.

Conference Breast Cancer Res Treat · February 2020 BACKGROUND: Given presumed differences in disease severity between young (≤ 45 years) and elderly (≥ 75 years) women with breast cancer, we sought to compare tumor histopathology, stage at presentation, patterns of care, and survival at the extremes of age ... Full text Link to item Cite

Nodal Response to Neoadjuvant Chemotherapy Predicts Receipt of Radiation Therapy After Breast Cancer Diagnosis.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2020 BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) is associated with improved overall survival (OS) in patients with breast cancer, but it is unclear how post-NACT response influences radiation therapy administration in p ... Full text Open Access Link to item Cite

Extent of axillary surgery in inflammatory breast cancer: a survival analysis of 3500 patients.

Journal Article Breast Cancer Res Treat · February 2020 PURPOSE: Inflammatory breast cancer (IBC) is an aggressive variant for which axillary lymph node (LN) dissection following neoadjuvant chemotherapy (NACT) remains standard of care. But with increasingly effective systemic therapy, it is unclear whether mor ... Full text Link to item Cite

Implications for Breast Cancer Restaging Based on the 8th Edition AJCC Staging Manual.

Journal Article Ann Surg · January 2020 OBJECTIVE: We assessed the changes that have resulted from the latest breast cancer staging guidelines and the potential impact on prognosis. BACKGROUND: Contemporary data suggest that combining anatomic staging and tumor biology yields a predictive synerg ... Full text Link to item Cite

Surgery for Men with Breast Cancer: Do the Same Data Still Apply?

Conference ANNALS OF SURGICAL ONCOLOGY · 2020 Cite

Decreasing rates of axillary lymph node dissections over time: Implications for surgical resident exposure and operative skills development.

Conference Am J Surg · October 2019 BACKGROUND: Sentinel lymph node biopsy has supplanted axillary lymph node dissection (ALND) in clinically node-negative breast cancer and select node-positive disease. We hypothesized a decreasing rate of both ALND and resident exposure over time. METHODS: ... Full text Link to item Cite

DCIS with Microinvasion: Is It In Situ or Invasive Disease?

Conference Ann Surg Oncol · October 2019 BACKGROUND: Ductal carcinoma in situ (DCIS) with microinvasion (DCISM) can be challenging in balancing the risks of overtreatment versus undertreatment. We compared DCISM, pure DCIS, and small volume (T1a) invasive ductal carcinoma (IDC) as related to hist ... Full text Link to item Cite

Neoadjuvant Endocrine Therapy Versus Neoadjuvant Chemotherapy in Node-Positive Invasive Lobular Carcinoma.

Conference Ann Surg Oncol · October 2019 BACKGROUND: Neoadjuvant chemotherapy (NACT) is often recommended for patients with node-positive invasive lobular carcinoma (ILC) despite unclear benefit in this largely hormone receptor-positive (HR+) group. We sought to compare overall survival (OS) betw ... Full text Link to item Cite

Clinical and pathological stage discordance among 433,514 breast cancer patients.

Journal Article Am J Surg · October 2019 BACKGROUND: We aim to determine clinical and pathological stage discordance rates and to evaluate factors associated with discordance. METHODS: Adults with clinical stages I-III breast cancer were identified from the National Cancer Data Base. Concordance ... Full text Open Access Link to item Cite

Ductal Carcinoma In Situ Management: All or Nothing, or Something in between?

Journal Article Current Breast Cancer Reports · September 15, 2019 Purpose of Review: Standard treatment for ductal carcinoma in situ (DCIS) is similar to that of invasive carcinoma. However, there is significant controversy regarding the true clinical implications of DCIS, and thus, the best management strategy. The aim ... Full text Cite

The Influence of Age on the Histopathology and Prognosis of Atypical Breast Lesions.

Journal Article J Surg Res · September 2019 BACKGROUND: Although several prognostic variables and risk factors for breast cancer are age-related, the association between age and risk of cancer with breast atypia is controversial. This study aimed to compare the type of breast atypia and risk of unde ... Full text Open Access Link to item Cite

The impact of chemotherapy sequence on survival in node-positive invasive lobular carcinoma.

Journal Article J Surg Oncol · August 2019 BACKGROUND AND OBJECTIVES: We sought to evaluate the impact of chemotherapy sequence on survival by comparing node-positive invasive lobular carcinoma (ILC) patients who received neoadjuvant (NACT) and adjuvant (ACT) chemotherapy. METHODS: cT1-4c, cN1-3 IL ... Full text Open Access Link to item Cite

Germline Genetic Testing: What the Breast Surgeon Needs to Know.

Journal Article Ann Surg Oncol · July 2019 PURPOSE: The American Society of Breast Surgeons (ASBrS) sought to provide educational guidelines for breast surgeons on how to incorporate genetic information and genomics into their practice. METHODS: A comprehensive nonsystematic review was performed of ... Full text Open Access Link to item Cite

Ductal carcinoma in situ in the elderly: what is the ideal treatment plan?

Journal Article Journal of Unexplored Medical Data · March 27, 2019 Full text Cite

Surgical Resection of the Primary Tumor in Women With De Novo Stage IV Breast Cancer: Contemporary Practice Patterns and Survival Analysis.

Journal Article Ann Surg · March 2019 OBJECTIVE: We evaluated patterns of surgical care and their association with overall survival among a contemporary cohort of women with stage IV breast cancer. BACKGROUND: Surgical resection of the primary tumor remains controversial among women with stage ... Full text Link to item Cite

Abstract P3-08-07: Distinct biological signatures describe differences in BRCA mutated subgroups

Conference Cancer Research · February 15, 2019 AbstractBackground: BRCA mutated (BRCA+) breast cancers are expected to have increased activation of Homologous Recombination Deficiency (HRD) and altered DNA damage repair pathways when compared to BRCA wil ... Full text Cite

Reframing the conversation about contralateral prophylactic mastectomy: Preparing women for postsurgical realities.

Conference Psychooncology · February 2019 OBJECTIVE: Women with unilateral, early-stage breast cancer and low genetic risk are increasingly opting for contralateral prophylactic mastectomy (CPM), a concerning trend because CPM offers few clinical benefits while increasing risks of surgical complic ... Full text Link to item Cite

Multidisciplinary Management of the Axilla in Patients with cT1-T2 N0 Breast Cancer Undergoing Primary Mastectomy: Results from a Prospective Single-Institution Series.

Journal Article Ann Surg Oncol · November 2018 BACKGROUND: The after mapping of the axilla: radiotherapy or surgery (AMAROS) trial concluded that for patients with cT1-2 N0 breast cancer and one or two positive sentinel lymph nodes (SLNs), axillary radiotherapy (AxRT) provides equivalent locoregional c ... Full text Link to item Cite

Axillary Nodal Evaluation in Elderly Breast Cancer Patients: Potential Effects on Treatment Decisions and Survival.

Conference Ann Surg Oncol · October 2018 BACKGROUND: Recent studies suggest that surgical lymph node (LN) evaluation may be omitted in select elderly breast cancer patients as it may not influence adjuvant therapy decisions. To evaluate differences in adjuvant therapy receipt and overall survival ... Full text Link to item Cite

The Association of Extent of Axillary Surgery and Survival in Women with N2-3 Invasive Breast Cancer.

Journal Article Ann Surg Oncol · October 2018 BACKGROUND: Although surgical management of the axilla for breast cancer continues to evolve, axillary lymphadenectomy remains the standard of care for women with advanced nodal disease. We sought to evaluate national patterns of care in axillary surgery, ... Full text Link to item Cite

The Clinical Significance of Breast-only and Node-only Pathologic Complete Response (pCR) After Neoadjuvant Chemotherapy (NACT): A Review of 20,000 Breast Cancer Patients in the National Cancer Data Base (NCDB).

Journal Article Ann Surg · October 2018 OBJECTIVE: To determine whether the association between overall survival (OS) and response to neoadjuvant chemotherapy (NACT) in breast cancer patients varies with tumor subtype and anatomic extent of pathologic complete response (pCR). BACKGROUND: pCR aft ... Full text Link to item Cite

It’s Not You, It’s Me: The Influence of Surgeon Gender on Patient Satisfaction Scores

Conference Journal of the American College of Surgeons · October 2018 Full text Cite

Metaplastic Breast Cancer Treatment and Outcomes in 2500 Patients: A Retrospective Analysis of a National Oncology Database.

Journal Article Ann Surg Oncol · August 2018 BACKGROUND: Metaplastic breast cancer (MBC) is characterized by chemoresistance and hematogenous spread. We sought to identify factors associated with improved MBC outcomes and increased likelihood of MBC diagnosis. METHODS: Women ≥ 18 years of age with st ... Full text Link to item Cite

Extent of axillary surgery in women with Stage IV breast cancer

Conference ANNALS OF SURGICAL ONCOLOGY · June 1, 2018 Link to item Cite

Immune profiling of BRCA-mutated breast cancers.

Conference Journal of Clinical Oncology · May 20, 2018 Full text Cite

Restaging de novo metastatic breast cancer to refine prognostic estimates.

Conference Journal of Clinical Oncology · May 20, 2018 Full text Cite

Seeking a no-regrets decision: Women's rationale for choosing contralateral prophylactic mastectomy (CPM).

Conference Journal of Clinical Oncology · March 1, 2018 152 Background: More women with early-stage unilateral breast cancer and low genetic risk are opting for CPM, despite their low risk of developing cancer in their healthy breast and evidence to demonstrate that CPM improves neith ... Full text Cite

Anatomy and Breast Cancer Staging: Is It Still Relevant?

Journal Article Surg Oncol Clin N Am · January 2018 Breast cancer staging concisely summarizes disease status, creating a framework for assessing and relaying prognostic information. The fundamental concepts and components of breast cancer staging are reviewed. The AJCC Cancer Staging Manual, which includes ... Full text Link to item Cite

Patient Age and Tumor Subtype Predict the Extent of Axillary Surgery Among Breast Cancer Patients Eligible for the American College of Surgeons Oncology Group Trial Z0011.

Journal Article Ann Surg Oncol · November 2017 BACKGROUND: The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial established the safety of omitting axillary lymph node dissection (ALND) for early-stage breast cancer patients with limited nodal disease undergoing lumpectomy. We examined t ... Full text Link to item Cite

Cost Effectiveness of Risk-Reducing Mastectomy versus Surveillance in BRCA Mutation Carriers with a History of Ovarian Cancer.

Journal Article Ann Surg Oncol · October 2017 BACKGROUND: The appropriate management of breast cancer risk in BRCA mutation carriers following ovarian cancer diagnosis remains unclear. We sought to determine the survival benefit and cost effectiveness of risk-reducing mastectomy (RRM) among women with ... Full text Link to item Cite

Cutaneous Burn Injury Promotes Shifts in the Bacterial Microbiome in Autologous Donor Skin: Implications for Skin Grafting Outcomes.

Journal Article Shock · October 2017 INTRODUCTION: The cutaneous microbiome maintains skin barrier function, regulates inflammation, and stimulates wound-healing responses. Burn injury promotes an excessive activation of the cutaneous and systemic immune response directed against commensal an ... Full text Link to item Cite

Oncologic Safety of Nipple-Sparing Mastectomy in Women with Breast Cancer.

Journal Article J Am Coll Surg · September 2017 BACKGROUND: Nipple-sparing mastectomy (NSM) has gained popularity for breast cancer treatment and prevention. There are limited data about long-term oncologic safety of this procedure. STUDY DESIGN: We reviewed oncologic outcomes of consecutive therapeutic ... Full text Link to item Cite

Risk assessment for breast cancer

Chapter · July 13, 2017 Genetic testing for individuals with familial or hereditary risk for breast cancer is essential to improving prevention and survival. Identifying unaffected BRCA1/2 mutation carriers before they develop breast cancer can reduce their risk and increase surv ... Full text Cite

Breast cancer risk models: a comprehensive overview of existing models, validation, and clinical applications.

Journal Article Breast Cancer Res Treat · July 2017 Numerous models have been developed to quantify the combined effect of various risk factors to predict either risk of developing breast cancer, risk of carrying a high-risk germline genetic mutation, specifically in the BRCA1 and BRCA2 genes, or the risk o ... Full text Link to item Cite

Cutaneous Burn Injury Modulates Urinary Antimicrobial Peptide Responses and the Urinary Microbiome.

Journal Article Crit Care Med · June 2017 OBJECTIVES: Characterization of urinary bacterial microbiome and antimicrobial peptides after burn injury to identify potential mechanisms leading to urinary tract infections and associated morbidities in burn patients. DESIGN: Retrospective cohort study u ... Full text Link to item Cite

A population-based analysis of treatment and outcomes in 2,500 metaplastic breast cancer patients.

Conference Journal of Clinical Oncology · May 20, 2017 532 Background: Metaplastic breast cancer (MBC) is a rare, aggressive variant that is often triple negative (TN). Current guidelines recommend use of standard receptor-based treatment for MBC despite evidence of chemoresistance. ... Full text Cite

The epidemiology of metaplastic breast cancer: A review of 2,500 cases from the national cancer database.

Conference Journal of Clinical Oncology · May 20, 2017 1570 Background: Metaplastic breast cancer (MBC) is a rare, aggressive, sarcomatoid breast cancer that was first described in 1973 but only became recognized as a histologically distinct entity in 2000. Given the paucity of data ... Full text Cite

Temporal associations between prognostic indicators and overall survival after breast cancer.

Conference Journal of Clinical Oncology · May 20, 2017 e18144 Background: Breast oncologists have little guidance on predicting long term outcomes after interval survival. We aim to evaluate the association of overall survival (OS) with select factors at multiple time points. Methods ... Full text Cite

Burn Injury Alters Epidermal Cholinergic Mediators and Increases HMGB1 and Caspase 3 in Autologous Donor Skin and Burn Margin.

Journal Article Shock · February 2017 Burn wound healing complications, such as graft failure or infection, are a major source of morbidity and mortality in burn patients. The mechanisms by which local burn injury alters epidermal barrier function in autologous donor skin and surrounding burn ... Full text Link to item Cite

Local Burn Injury Promotes Defects in the Epidermal Lipid and Antimicrobial Peptide Barriers in Human Autograft Skin and Burn Margin: Implications for Burn Wound Healing and Graft Survival.

Journal Article J Burn Care Res · 2017 Burn injury increases the risk of morbidity and mortality by promoting severe hemodynamic shock and risk for local or systemic infection. Graft failure due to poor wound healing or infection remains a significant problem for burn subjects. The mechanisms b ... Full text Link to item Cite

Should New "No Ink On Tumor" Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: No consensus exists for clear margins for breast-conserving surgery for pure ductal carcinoma in situ (DCIS). We examined the implications of applying a "no ink on tumor" standard for pure DCIS by correlating clear margin width with rates of re ... Full text Link to item Cite

Factors Associated with Recurrence Rates and Long-Term Survival in Women Diagnosed with Breast Cancer Ages 40 and Younger.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: Young age at breast cancer diagnosis has been associated with increased risk of recurrence and mortality. We reevaluated this assumption in a large, modern cohort of women diagnosed with breast cancer at age ≤40 years. METHODS: We identified wo ... Full text Link to item Cite

What's New in Genetic Testing for Cancer Susceptibility?

Journal Article Oncology (Williston Park) · September 15, 2016 The advent of next-generation sequencing, and its transition further into the clinic with the US Food and Drug Administration approval of a cystic fibrosis assay in 2013, have increased the speed and reduced the cost of DNA sequencing. Coupled with a histo ... Link to item Cite

What’s new in genetic testing for cancer susceptibility?

Journal Article ONCOLOGY (United States) · September 15, 2016 Cite

Flame Burns

Chapter · 2016 Full text Cite

Abstract P1-10-04: Post-operative imaging after atypical ductal hyperplasia excision: The findings and costs

Conference Cancer Research · May 1, 2015 AbstractIntroduction: With a reported incidence of 2-12% in breast biopsy specimens, the appropriate management of atypical ductal hyperplasia (ADH) remains in evolution. At present, the optimal screening gu ... Full text Cite

Hospital Selection and Breast Cancer Patients: Who Goes Where

Conference ANNALS OF SURGICAL ONCOLOGY · May 1, 2015 Link to item Cite

Should all branch-duct intraductal papillary mucinous neoplasms be resected?

Journal Article Am J Surg · March 2015 BACKGROUND: The relationship between branch-duct intraductal papillary mucinous neoplasms (IPMNs) and malignancy remains controversial and difficult to assess. METHODS: Between January 1, 1999 and January 1, 2013, we identified 84 patients with IPMN who un ... Full text Link to item Cite

Does practice make perfect? Resident experience with breast surgery influences excision adequacy.

Journal Article Am J Surg · March 2015 BACKGROUND: The adequacy of breast-conserving surgery (BCS) for invasive or in situ disease is largely determined by the final surgical margins. Although margin status is associated with various clinicopathologic features, the influence of resident involve ... Full text Link to item Cite

The changing spectrum of surgically treated cystic neoplasms of the pancreas.

Journal Article HPB Surg · 2015 Introduction. While the incidence of pancreatic cystic lesions has steadily increased, we sought to evaluate the changes in their surgical management. Methods. Patients with pancreatic cystic lesions who underwent surgical resection from 2003 to 2013 were ... Full text Link to item Cite

Dynamic Role of Host Stress Responses in Modulating the Cutaneous Microbiome: Implications for Wound Healing and Infection.

Journal Article Adv Wound Care (New Rochelle) · January 1, 2015 Significance: Humans are under constant bombardment by various stressors, including psychological anxiety and physiologic injury. Understanding how these stress responses influence the innate immune system and the skin microbiome remains elusive due to the ... Full text Link to item Cite

Flame Burns

Chapter · 2015 Full text Cite

Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin.

Journal Article Crit Care Med · June 2014 OBJECTIVES: Our objective was to characterize the mechanisms by which local burn injury compromises epithelial barrier function in burn margin, containing the elements necessary for healing of the burn site, and in distal unburned skin, which serves as pot ... Full text Link to item Cite

Should All Branch-Duct IPMN's Be Resected?

Conference GASTROENTEROLOGY · May 1, 2014 Link to item Cite

Tu1631 Should All Branch-Duct IPMN's Be Resected?

Journal Article Gastroenterology · May 2014 Full text Cite

LOCAL BURN INJURY PROMOTES CHOLINERGIC DYSREGULATION IN HUMAN EPIDERMIS

Conference WOUND REPAIR AND REGENERATION · March 1, 2014 Link to item Cite

The Association between Survival and the Pathologic Features of Periampullary Tumors Varies over Time.

Journal Article HPB Surg · 2014 Introduction. Several histopathologic features of periampullary tumors have been shown to be correlated with prognosis. We evaluated their association with mortality at multiple time points. Methods. A retrospective chart review identified 207 patients wit ... Full text Link to item Cite

Quality of life after pancreaticoduodenectomy: what are the long-term effects?

Conference Journal of the American College of Surgeons · September 2013 Full text Cite

Post-operative Surveillance of Ductal Carcinoma In Situ

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2013 Link to item Cite

Chronic alcohol exposure renders epithelial cells vulnerable to bacterial infection.

Journal Article PLoS One · 2013 Despite two centuries of reports linking alcohol consumption with enhanced susceptibility to bacterial infections and in particular gut-derived bacteria, there have been no studies or model systems to assess the impact of long-term alcohol exposure on the ... Full text Link to item Cite

Nicotinic acetylcholine receptor stimulation impairs epidermal permeability barrier function and recovery and modulates cornified envelope proteins.

Journal Article Life Sci · November 27, 2012 AIM: To characterize how nicotinic acetylcholine receptors (nAChRs) influence epidermal barrier function and recovery following prolonged stress or direct nAChR activation or antagonism. MAIN METHODS: Mice were subjected to psychological stress or treated ... Full text Link to item Cite

Does atypical ductal hyperplasia require 6 months of postoperative surveillance?

Conference Journal of Clinical Oncology · September 20, 2012 60 Background: Standard follow-up imaging for women with a history of breast cancer is well defined, but the appropriate screening guidelines for other high risk breast lesions, such as atypical ductal hyperplasia (ADH), remain u ... Full text Cite

Local burn injury modulates global cutaneous barrier function

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · May 1, 2012 Link to item Cite

Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds.

Journal Article J Burn Care Res · 2012 Thousands of patients suffer from burn injuries each year, yet few therapies have been developed to accelerate the wound healing process. Most fibroblast growth factors (FGFs) have been extensively evaluated but only a few have been found to participate in ... Full text Link to item Cite

A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors.

Journal Article Nano Lett · December 2007 Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing ... Full text Link to item Cite