Scholars@Duke
Jessica Seidelman

Jessica Seidelman

Associate Professor of Medicine
Medicine, Infectious Diseases

Selected Publications

Impact of Wound Closure Technique on Surgical Site Infection After Lower Extremity Bypass Surgery.

Journal Article Ann Vasc Surg · December 2024 BACKGROUND: Surgical site infections (SSIs) are among the most common complications after lower extremity bypass (LEB). Both patient and hospital-related factors have been associated with SSI after LEB; however, the impact of surgical closure technique on ... Full text Link to item Cite

Diagnosis and Management of Hand Infections.

Journal Article J Hand Surg Am · December 2024 Hand and upper-extremity infections span a broad spectrum of presentations for the hand surgeon, primary care provider, and emergency medicine practitioner. As many hand infections arise from penetrating trauma, knowledge of the offending pathogen, locatio ... Full text Link to item Cite

Characterizing Early-Onset Surgical Site Infection After Lower Extremity Bypass Surgery.

Journal Article Ann Vasc Surg · November 22, 2024 BACKGROUND: Surgical site infections (SSI) are the most common complication following lower extremity bypass (LEB) surgery. SSIs contribute to significant patient morbidity and healthcare expenditure, and accurate detection of SSIs remains an important ste ... Full text Link to item Cite

Static Versus Articulating Spacer: Does Infectious Pathogen Type Affect Treatment Success?

Journal Article Clin Orthop Relat Res · October 1, 2024 BACKGROUND: Treatment with a static or an articulating antibiotic-containing spacer is a common strategy for treating periprosthetic joint infection (PJI), yet many patients have persistent infections after spacer treatment. Although previous studies have ... Full text Link to item Cite

Blood culture algorithm implementation in emergency department patients as a diagnostic stewardship intervention.

Journal Article Am J Infect Control · September 2024 OBJECTIVE: Blood cultures (BCx) are important for selecting appropriate antibiotic treatment. Ordering BCx for conditions with a low probability of bacteremia has limited utility, thus improved guidance for ordering BCx is needed. Inpatient studies have im ... Full text Link to item Cite

The Effect of Nutritional Status in the Treatment of Periprosthetic Joint Infections in Total Hip Arthroplasty.

Journal Article J Arthroplasty · September 2024 BACKGROUND: Periprosthetic joint infections (PJIs) continue to be a complication that plagues arthroplasty. Albumin is a surrogate marker for nutrition as well as chronic inflammation, and hypoalbuminemia increases the risk of complications in arthroplasty ... Full text Link to item Cite

Clinic of Hope: bridging infectious disease and orthopaedic surgery in prosthetic joint infection management.

Journal Article BMJ Open Qual · August 21, 2024 Prosthetic joint infections (PJIs) following total joint arthroplasty are a significant and costly complication. To address fragmented care typically seen with separate management, we established a combined infectious disease and orthopaedic surgery clinic ... Full text Link to item Cite

Native Joint Septic Arthritis

Journal Article Antibiotics · July 1, 2024 Native joint septic arthritis (NJSA) is a severe and rapidly progressing joint infection, predominantly bacterial but also potentially fungal or viral, characterized by synovial membrane inflammation and joint damage, necessitating urgent and multidiscipli ... Full text Cite

Multisite Study of the Management of Musculoskeletal Infection After Trauma: The MMUSKIT Study.

Journal Article Open Forum Infect Dis · June 2024 BACKGROUND: The optimal duration and choice of antibiotic for fracture-related infection (FRI) is not well defined. This study aimed to determine whether antibiotic duration (≤6 vs >6 weeks) is associated with infection- and surgery-free survival. The seco ... Full text Link to item Cite

Outcomes After Pseudomonas Prosthetic Joint Infections.

Journal Article J Am Acad Orthop Surg · May 15, 2024 BACKGROUND: Pseudomonas species are a less common but devastating pathogen family in prosthetic joint infections (PJIs). Despite advancements in management, Pseudomonas PJIs remain particularly difficult to treat because of limited antibiotic options and r ... Full text Link to item Cite

A cluster of three extrapulmonary Mycobacterium abscessus infections linked to well-maintained water-based heater-cooler devices.

Journal Article Infect Control Hosp Epidemiol · May 2024 BACKGROUND: Various water-based heater-cooler devices (HCDs) have been implicated in nontuberculous mycobacteria outbreaks. Ongoing rigorous surveillance for healthcare-associated M. abscessus (HA-Mab) put in place following a prior institutional outbreak ... Full text Link to item Cite

The impact of minimally invasive surgical approaches on surgical-site infections.

Journal Article Infect Control Hosp Epidemiol · May 2024 We performed a literature review to describe the risk of surgical-site infection (SSI) in minimally invasive surgery (MIS) compared to standard open surgery. Most studies reported decreased SSI rates among patients undergoing MIS compared to open procedure ... Full text Link to item Cite

Implementation of a diagnostic stewardship intervention to improve blood-culture utilization in 2 surgical ICUs: Time for a blood-culture change.

Journal Article Infect Control Hosp Epidemiol · April 2024 OBJECTIVE: We compared the number of blood-culture events before and after the introduction of a blood-culture algorithm and provider feedback. Secondary objectives were the comparison of blood-culture positivity and negative safety signals before and afte ... Full text Link to item Cite

Comparative epidemiology of hospital-onset bloodstream infections (HOBSIs) and central line-associated bloodstream infections (CLABSIs) across a three-hospital health system.

Journal Article Infect Control Hosp Epidemiol · March 20, 2024 OBJECTIVE: To evaluate the comparative epidemiology of hospital-onset bloodstream infection (HOBSI) and central line-associated bloodstream infection (CLABSI). DESIGN AND SETTING: Retrospective observational study of HOBSI and CLABSI across a three-hospita ... Full text Link to item Cite

How We Approach Suppressive Antibiotic Therapy Following Debridement, Antibiotics, and Implant Retention for Prosthetic Joint Infection.

Journal Article Clin Infect Dis · January 25, 2024 The optimal treatment of prosthetic joint infection (PJI) remains uncertain. Patients undergoing debridement, antibiotics, and implant retention (DAIR) receive extended antimicrobial treatment, and some experts leave patients at perceived highest risk of r ... Full text Link to item Cite

Using clinical decision support to improve urine testing and antibiotic utilization.

Journal Article Infect Control Hosp Epidemiol · October 2023 OBJECTIVE: Urine cultures collected from catheterized patients have a high likelihood of false-positive results due to colonization. We examined the impact of a clinical decision support (CDS) tool that includes catheter information on test utilization and ... Full text Open Access Link to item Cite

Colon surgical-site infections and the impact of "present at the time of surgery (PATOS)" in a large network of community hospitals.

Journal Article Infect Control Hosp Epidemiol · August 2023 OBJECTIVES: To describe the epidemiology of complex colon surgical procedures (COLO), stratified by present at time of surgery (PATOS) surgical-site infections (SSIs) and non-PATOS SSIs and their impact on the epidemiology of colon-surgery SSIs. DESIGN: Re ... Full text Link to item Cite

Cutibacterium positive cultures in total joint arthroplasty: a comparison of the hip, knee, and shoulder.

Journal Article Int Orthop · August 2023 PURPOSE: Cutibacterium spp. (formerly Propionibacterium) is a slow growing, Gram-positive, anaerobic bacteria and is an emerging clinical entity in prosthetic joint infection (PJI). This study compares the presentation, surgical management, and post-operat ... Full text Link to item Cite

The impact of a comprehensive coronavirus disease 2019 (COVID-19) infection prevention bundle on non-COVID-19 hospital-acquired respiratory viral infection (HA-RVI) rates.

Journal Article Infect Control Hosp Epidemiol · June 2023 After implementing a coronavirus disease 2019 (COVID-19) infection prevention bundle, the incidence rate ratio (IRR) of non-severe acute respiratory coronavirus virus 2 (non-SARS-CoV-2) hospital-acquired respiratory viral infection (HA-RVI) was significant ... Full text Link to item Cite

D-Dimer, Erythrocyte Sedimentation Rate, and C-Reactive Protein Sensitivities for Periprosthetic Joint Infection Diagnosis.

Journal Article J Arthroplasty · May 2023 BACKGROUND: There is contradicting evidence on the diagnostic value of inflammatory biomarkers for periprosthetic joint infection (PJI). We sought to quantify the sensitivity of D-dimer for acute and chronic PJI diagnosis and evaluate D-dimer lab values in ... Full text Link to item Cite

Use of Statistical Process Control Methods for Early Detection of Healthcare Facility-Associated Nontuberculous Mycobacteria Outbreaks: A Single-Center Pilot Study.

Journal Article Clin Infect Dis · April 17, 2023 BACKGROUND: Nontuberculous mycobacteria (NTM) are emerging pathogens increasingly implicated in healthcare facility-associated (HCFA) infections and outbreaks. We analyzed the performance of statistical process control (SPC) methods in detecting HCFA NTM o ... Full text Link to item Cite

Surgical site infection trends in community hospitals from 2013 to 2018.

Journal Article Infect Control Hosp Epidemiol · April 2023 OBJECTIVE: Sparse recent data are available on the epidemiology of surgical site infections (SSIs) in community hospitals. Our objective was to provide updated epidemiology data on complex SSIs in community hospitals and to characterize trends of SSI preva ... Full text Link to item Cite

Antimicrobial treatment of patients with a periprosthetic joint infection: basic principles.

Journal Article Arthroplasty · March 2, 2023 The antibiotic treatment of periprosthetic joint infections (PJI) is complicated by the presence of biofilm produced by bacteria on the abiotic surface of the implant. Bacteria within the deeper layers of the biofilm become metabolically less active, resul ... Full text Link to item Cite

Surgical Site Infection Prevention: A Review.

Journal Article JAMA · January 2023 ImportanceApproximately 0.5% to 3% of patients undergoing surgery will experience infection at or adjacent to the surgical incision site. Compared with patients undergoing surgery who do not have a surgical site infection, those with a surgical si ... Full text Cite

Using the COM-B model to identify barriers to and facilitators of evidence-based nurse urine-culture practices.

Journal Article Antimicrob Steward Healthc Epidemiol · 2023 Our surveys of nurses modeled after the Capability, Opportunity, and Motivation Model of Behavior (COM-B model) revealed that opportunity and motivation factors heavily influence urine-culture practices (behavior), in addition to knowledge (capability). Un ... Full text Open Access Link to item Cite

The Great Hypocrisy: Neoliberalism’s Critique of Modern Monetary Theory

Journal Article Journal of Economic Issues · January 1, 2023 There is something disingenuous, something hypocritical in the vociferous critiques of Modern Monetary Theory (MMT). The hypocrisy among neoliberal economists reveals itself in tacitly accepting quantitative easing (QE) while criticizing MMT. QE involves c ... Full text Cite

MYCOBACTERIAL CULTURES COMING IN HANDY: TUBERCULOSIS OSTEOMYELITIS OF THE WRIST

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · 2023 Cite

Challenges in hospital-acquired coronavirus disease 2019 (COVID-19) surveillance and attribution of infection source.

Journal Article Infect Control Hosp Epidemiol · December 2022 We performed surveillance for hospital-acquired COVID-19 (HA-COVID-19) and compared time-based, electronic definitions to real-time adjudication of the most likely source of acquisition. Without real-time adjudication, nearly 50% of HA-COVID-19 cases ident ... Full text Link to item Cite

An analysis of 90-day emergency department visits after peripherally inserted central catheter (PICC) placement for prosthetic joint infection.

Journal Article Infect Control Hosp Epidemiol · December 2022 OBJECTIVE: Research on complications with peripherally inserted central catheter (PICC) lines that are placed for the treatment of prosthetic joint infection (PJI) after total hip arthroplasty (THA) and total knee arthroplasty (TKA) is scarce. We investiga ... Full text Link to item Cite

Comparison of metrics used to track central-line-associated bloodstream infections (CLABSIs) and catheter-associated urinary tract infections (CAUTIs) across a regional network.

Journal Article Infect Control Hosp Epidemiol · November 2022 The paradoxical relationship between standardized infection ratio and standardized utilization ratio for catheter-associated urinary tract infections (CAUTIs) in contrast to central-line-associated bloodstream infections (CLABSIs), in addition to CAUTI def ... Full text Link to item Cite

In pursuit of the holy grail: Improving C. difficile testing appropriateness with iterative electronic health record clinical decision support and targeted test restriction.

Journal Article Infect Control Hosp Epidemiol · July 2022 OBJECTIVE: To determine the impact of electronic health record (EHR)-based interventions and test restriction on Clostridioides difficile tests (CDTs) and hospital-onset C. difficile infection (HO-CDI). DESIGN: Quasi-experimental study in 3 hospitals. SETT ... Full text Link to item Cite

The impact of patient-reported penicillin or cephalosporin allergy on surgical site infections.

Journal Article Infect Control Hosp Epidemiol · July 2022 OBJECTIVE: To determine the impact of a documented penicillin or cephalosporin allergy on the development of surgical site infections (SSIs). BACKGROUND: Appropriate preoperative antibiotic prophylaxis reduces SSI risk, but documented antibiotic allergies ... Full text Link to item Cite

Cutibacterium Positive Cultures in Total Hip Arthroplasty: Contaminant or Pathogen?

Journal Article J Arthroplasty · July 2022 BACKGROUND: Cutibacterium spp. is an emerging pathogen in total hip arthroplasty (THA) that is not well evaluated in the literature. This study reported on the presentation and management of THA complicated by positive intraoperative Cutibacterium cultures ... Full text Link to item Cite

Impact of Antibiotic Stewardship Rounds in the Intensive Care Setting: A Prospective Cluster-Randomized Crossover Study.

Journal Article Clin Infect Dis · June 10, 2022 BACKGROUND: Few groups have formally studied the effect of dedicated antibiotic stewardship rounds (ASRs) on antibiotic use (AU) in intensive care units (ICUs). METHODS: We implemented weekly ASRs using a 2-arm, cluster-randomized, crossover study in 5 ICU ... Full text Link to item Cite

Prosthetic Knee Infection With Coagulase-Negative Staphylococcus: A Harbinger of Poor Outcomes.

Journal Article J Arthroplasty · June 2022 BACKGROUND: Coagulase-negative staphylococci (CoNS) are biofilm-producing pathogens whose role in periprosthetic joint infection (PJI) is increasing. There is little data on the prognosis and treatment considerations in the setting of PJI. We sought to eva ... Full text Link to item Cite

Erratum to 'Corynebacterium Total Hip and Knee Arthroplasy Prosthetic Joint Infections' [Arthroplasty Today 6 (2020) 163-168].

Journal Article Arthroplast Today · June 2022 [This corrects the article DOI: 10.1016/j.artd.2020.03.008.]. ... Full text Link to item Cite

Endogenous Methicillin-Resistant Staphylococcus Aureus (MRSA) Endophthalmitis: A Six-year Series at a Tertiary Care Center.

Journal Article Ocul Immunol Inflamm · 2022 PURPOSE: To investigate the clinical outcomes of methicillin-resistant Staphylococcus aureus (MRSA) endophthalmitis. METHODS: Clinical courses were reviewed for 17 eyes (15 patients) with endogenous MRSA endophthalmitis based on positive blood and vitreous ... Full text Link to item Cite

Evaluation of Abbreviated HLD Protocols for Duodenoscopes With Disposable Tips

Conference AMERICAN JOURNAL OF GASTROENTEROLOGY · 2022 Cite

Surgical Site Infections.

Chapter · December 2021 Surgical site infections (SSIs) are among the most common and most costly health care-associated infections, leading to adverse patient outcomes and death. Wound contamination occurs with each incision, but proven strategies exist to decrease the risk of S ... Full text Link to item Cite

Surgical Site Infections

Journal Article Infectious Disease Clinics of North America · December 1, 2021 Full text Cite

Pseudo-outbreak of adenovirus in bronchoscopy suite.

Journal Article Infect Control Hosp Epidemiol · August 2021 Full text Link to item Cite

The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches.

Journal Article Genome Med · July 5, 2021 BACKGROUND: Candidemia is one of the most common nosocomial bloodstream infections in the United States, causing significant morbidity and mortality in hospitalized patients, but the breadth of the host response to Candida infections in human patients rema ... Full text Open Access Link to item Cite

Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel - 33 U.S. Sites, January-March 2021.

Journal Article MMWR Morb Mortal Wkly Rep · May 21, 2021 Throughout the COVID-19 pandemic, health care personnel (HCP) have been at high risk for exposure to SARS-CoV-2, the virus that causes COVID-19, through patient interactions and community exposure (1). The Advisory Committee on Immunization Practices recom ... Full text Link to item Cite

Early experience with universal preprocedural testing for SARS-CoV-2 in a relatively low-prevalence area.

Journal Article Infect Control Hosp Epidemiol · March 2021 We implemented universal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing of patients undergoing surgical procedures as a means to conserve personal protective equipment (PPE). The rate of asymptomatic coronavirus disease 2019 (COVID-19 ... Full text Open Access Link to item Cite

1.5-Stage Exchange Arthroplasty for Total Knee Arthroplasty Periprosthetic Joint Infections.

Journal Article J Arthroplasty · March 2021 BACKGROUND: Periprosthetic joint infection (PJI) in total knee arthroplasty (TKA) is a challenging problem. The purpose of this study was to outline a novel technique to treat TKA PJI. We define 1.5-stage exchange arthroplasty as placing an articulating sp ... Full text Link to item Cite

Endogenous Candida endophthalmitis: Who is really at risk?

Journal Article J Infect · February 2021 OBJECTIVES: The Infectious Disease Society of America recommends that all patients with candidemia undergo a dilated retinal exam to exclude endogenous Candida endophthalmitis. Our objective was to determine if there are significant risk factors in candide ... Full text Link to item Cite

Navigating reflex urine culture practices in community hospitals: Need for a validated approach.

Journal Article Am J Infect Control · December 2020 We performed a descriptive study of reflex urine culture (RUC) practices across 51 community hospitals in southeastern United States. We found that 26 unique reflexing criteria were used in 28 hospitals. Only 14% hospitals of hospitals that offered RUC res ... Full text Link to item Cite

Reduction of Central-Line–Associated Bloodstream Infections in a Spinal Cord Injury Unit

Conference Infection Control & Hospital Epidemiology · October 2020 Background: Central-line–associated bloodstream infections (CLABSIs) are a complication of indwelling central venous catheters, which increase morbidity, mortality, and cost to patients. Objective: Due ... Full text Cite

Comparison of Bacterial Contamination in a Children’s Outpatient Clinic: General Medicine Versus Pulmonary Units

Conference Infection Control & Hospital Epidemiology · October 2020 Background: The bacteria that inhabit outpatient healthcare facilities influence patient outcomes and recovery, although the diversity and quantity of these bacterial communities is largely unknown. Whether differences in bac ... Full text Cite

Catheter-Associated Urinary Tract Infections (CAUTIs) Reduction: A Multidisciplinary Approach

Conference INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY · October 2020 Link to item Cite

Comparison of Metrics Used to Track CLABSIs and CAUTIs Across a Regional Network

Conference Infection Control & Hospital Epidemiology · October 2020 Background: The standardized infection ratio (SIR) is the nationally adopted metric used to track and compare catheter-associated urinary tract infections (CAUTIs) and central-line– associated bloodstream infections (CLABSIs) ... Full text Cite

CAUTIs in Patients With Thoracic Epidurals

Conference Infection Control & Hospital Epidemiology · October 2020 Background: The Surgical Care Improvement Project 9 (SCIP 9) mandates the removal of urinary catheters within 48 hours following surgery to reduce the risk of catheter-associated urinary tract infections (CAUTIs). Although pa ... Full text Cite

Corynebacterium Total Hip and Knee Arthroplasy Prosthetic Joint Infections.

Journal Article Arthroplast Today · June 2020 Prosthetic joint infections (PJIs) are typically caused by Staphylococcus aureus and coagulase-negative Staphylococci species. Corynebacterium species are microorganisms of the human skin and mucous membranes that are often considered contaminants when gro ... Full text Link to item Cite

Reflex Urine Culture Practices in a Regional Community Hospital Network

Conference Infection Control & Hospital Epidemiology · 2020 Background: Reflex urine cultures (RUCs) have the potential to reduce unnecessary urine cultures and antibiotic use. However, urinalysis parameters that best predict true infection are unknown. In this study, we surveyed different RUC practices in laborato ... Full text Link to item Cite

The Last Gasp of Neoliberalism

Journal Article Journal of Economic Issues · April 3, 2019 Abstract: The ideas of both Thorstein Veblen and Karl Polanyi shed light on understanding the last gasp of neoliberalism. The last gasp refers to Donald Trump’s abandonment of free trade, long considered a cornerstone of the neoliberal agenda, and his over ... Full text Cite

Mycobacterium avium pseudo-outbreak associated with an outpatient bronchoscopy clinic: Lessons for reprocessing.

Journal Article Infect Control Hosp Epidemiol · January 2019 We identified a pseudo-outbreak of Mycobacterium avium in an outpatient bronchoscopy clinic following an increase in clinic procedure volume. We terminated the pseudo-outbreak by increasing the frequency of automated endoscope reprocessors (AER) filter cha ... Full text Open Access Link to item Cite

Neurosurgical Device-Related Infections.

Journal Article Infect Dis Clin North Am · December 2018 In this review article, we discuss the epidemiology, microbiology, diagnosis, treatment and prevention of infections associated with cerebrospinal fluid shunts, cerebrospinal fluid drains, and deep brain stimulators. We also briefly discuss prevention stra ... Full text Link to item Cite

An educational initiative in response to identified PrEP prescribing needs among PCPs in the Southern U.S.

Journal Article AIDS Care · May 2018 Pre-exposure prophylaxis (PrEP) is an effective HIV prevention method, but many primary care physicians (PCPs) have not incorporated PrEP into practice. While PrEP may be a key strategy to reducing high HIV transmission rates in the southern US, knowledge ... Full text Link to item Cite

The Reply.

Journal Article Am J Med · June 2017 Full text Link to item Cite

A Veblenian Analysis of For-Profit Universities

Journal Article Journal of Economic Issues · April 3, 2017 Abstract: Education policy has been guided by two seemingly opposing forces: (i) broadening access to the community’s knowledge base and (ii) privatizing the costs of that access. Broadening access entails helping marginal students — the poor, minorities, ... Full text Cite

Milestones for Internal Medicine Sub-interns.

Journal Article Am J Med · July 2015 BACKGROUND: As residency programs move toward measuring milestones for competency-based education assessment, medical schools will need to collaborate with residencies to determine competencies for graduating students. The objective of this study is to def ... Full text Link to item Cite

A stochastic structural reliability model explains rotator cuff repair retears

Journal Article International Biomechanics · January 1, 2014 High rates of tendon retear following surgical repair of large rotator cuff tears have been reported. This study developed a probabilistic structural reliability model of retear with potential to guide quality improvement interventions. A probabilistic bio ... Full text Cite

Incidental, subsolid pulmonary nodules at CT: etiology and management.

Journal Article Cancer Imaging · September 23, 2013 Pulmonary nodules, both solid and subsolid, are common incidental findings on computed tomography (CT) studies. Subsolid nodules (SSNs) may be further classified as either pure ground-glass nodules or part-solid nodules. The differential diagnosis for an S ... Full text Link to item Cite

Closure of Gastro-pleuro-bronchial Fistula With Polymethyl Methacrolate and Endoclips: A Rare Complication of Gastric Bypass Surgery.

Journal Article J Bronchology Interv Pulmonol · January 2010 A unique noninvasive method was used to close a fistulous connection between the stomach and lung of a woman with recurrent bouts of pneumonia resulting from a rare complication of gastric bypass surgery. ... Full text Link to item Cite