Scholars@Duke
Joel Charles Morgenlander

Joel Charles Morgenlander

Professor of Neurology
Neurology, General & Community Neurology
joel.morgenlander@duke.edu
Duke Box 3394, Durham, NC 27710
0395 Duke South, Durham, NC

Selected Publications

Neuropsychological normative standards for late career physicians.

Journal Article Clin Neuropsychol · November 2024 Objective: In the context of an aging, vital physician workforce, there is clear value in establishing a specialized neuropsychological normative dataset for the evaluation of late career physicians practicing clinical medicine. Methods: Physicians aged 60 ... Full text Link to item Cite

Letter to the Editor Response.

Journal Article J Neurosurg Case Lessons · October 14, 2024 Full text Link to item Cite

Early cerebral venous drainage associated with focal seizures: a correlation of digital subtraction angiography and electroencephalography. Illustrative case.

Journal Article J Neurosurg Case Lessons · April 29, 2024 BACKGROUND: Early venous drainage is a critical diagnostic feature of arteriovenous malformations (AVMs) and arteriovenous fistulas (AVFs). However, other conditions associated with early venous drainage can mimic AVMs and AVFs and mislead the treating phy ... Full text Link to item Cite

Yoga and Mindfulness Intervention for Concussion Recovery.

Journal Article Int J Yoga Therap · January 1, 2023 Concussion imposes a substantial global health burden, and few evidence-based treatments that approach concussion treatment holistically are available. Moreover, early intervention is important before concussion symptoms become chronic and more refractory ... Full text Link to item Cite

Multiple Cranial Neuropathies as the Initial Presentation of Primary Ductal Adenocarcinoma of the Lacrimal Gland.

Journal Article Ophthalmic Plast Reconstr Surg · May 2022 Primary ductal adenocarcinoma of the lacrimal gland is a rare, aggressive malignancy that clinically and histologically resembles salivary duct carcinoma. Similar to other malignant epithelial lacrimal gland tumors, ductal adenocarcinoma typically presents ... Full text Link to item Cite

The clinical presentation and treatment of MOG antibody disease at a single academic center: A case series.

Journal Article J Neuroimmunol · December 15, 2019 OBJECTIVES: To describe the clinical presentation of MOG antibody disease (MOG-AD) in a series of patients at a single academic center. METHODS: We performed a retrospective review of patients with MOG antibodies. RESULTS: We review the clinical presentati ... Full text Link to item Cite

Loss of Vestibular Ocular Reflex in Nonconvulsive Status Epilepticus.

Journal Article Neurocrit Care · June 2019 BACKGROUND: Electroencephalogram (EEG) findings of generalized periodic discharges (GPDs) with triphasic morphology were introduced as a metabolic phenomenon, but more recently have been associated with epileptic phenomenon. Resolution of EEG findings alon ... Full text Link to item Cite

Emerging Subspecialties in Neurology: Sports neurology training and certification: An overview in 2018.

Journal Article Neurology · November 20, 2018 Sports neurology is a relatively new specialty in neurology. Interested trainees may find it difficult to learn about issues in sports neurology both in medical school and residency. This review highlights what the current state is in medical school and re ... Full text Link to item Cite

Authors respond

Journal Article Neurology Clinical Practice · October 1, 2016 Full text Cite

The Duke neurology advanced practice provider residency: Its time has come.

Journal Article Neurol Clin Pract · June 2016 The acknowledgment that specialization in neurology based on a clinician's extensive background in neuroscience contributes to expertise in patient care was a motivating factor in developing neurology residency programs. The increasing demand for more and ... Full text Link to item Cite

Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS.

Journal Article Neurol Neuroimmunol Neuroinflamm · June 2015 OBJECTIVE: To assess the safety, tolerability, and preliminary efficacy of NP001, a novel immune regulator of inflammatory monocytes/macrophages, for slowing progression of amyotrophic lateral sclerosis (ALS). METHODS: This was a phase 2 randomized, double ... Full text Link to item Cite

The man with hemi-cape dysesthesias.

Journal Article Neurol Clin Pract · February 2013 Full text Link to item Cite

Time to diagnosis in the National Registry of Veterans with Amyotrophic Lateral Sclerosis.

Journal Article Amyotroph Lateral Scler · 2010 Our objective was to determine the interval from symptom onset to diagnosis, and to evaluate associated factors in a cohort of U.S. Veterans with motor neuron diseases. We retrospectively evaluated 1359 patients enrolled in the National Registry of Veteran ... Full text Link to item Cite

Adult cases of leukoencephalopathy, cerebral calcifications, and cysts: expanding the spectrum of the disorder.

Journal Article J Neuropathol Exp Neurol · April 2009 Leukoencephalopathy with cerebral calcifications and cysts (LCC) was first reported in children who developed cognitive decline and variable extrapyramidal, cerebellar, and pyramidal signs, with or without seizures. Leukoencephalopathy with cerebral calcif ... Full text Link to item Cite

Education research: neurology residency training in the new millennium.

Journal Article Neurology · January 27, 2009 OBJECTIVE: To survey adult neurology program directors (ANPD) to identify their most pressing needs at a time of dramatic change in neurology resident education. METHODS: All US ANPD were surveyed in 2007 using an instrument adjusted from a 1999 survey ins ... Full text Link to item Cite

Factors associated with survival in the National Registry of Veterans with ALS.

Journal Article Amyotroph Lateral Scler · 2009 The clinical course of patients with ALS is highly variable. While the median survival time from symptom onset is 2-4 years, there are reports of survival ranging from less than a year to more than 40 years. Such variability makes planning difficult for pa ... Full text Link to item Cite

Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis: the GENEVA study. Rationale, study design and demographic characteristics.

Journal Article Neuroepidemiology · 2008 Recent reports of a potentially increased risk of amyotrophic lateral sclerosis (ALS) for veterans deployed to the 1990-1991 Persian Gulf War prompted the Department of Veterans Affairs to establish a National Registry of Veterans with ALS, charged with th ... Full text Link to item Cite

The National Registry of Veterans with amyotrophic lateral sclerosis.

Journal Article Neuroepidemiology · 2008 BACKGROUND: The Department of Veterans Affairs (VA) Cooperative Studies Program has established a National Registry of Veterans with Amyotrophic Lateral Sclerosis (ALS). This article describes the objectives, methods, and sample involved in the registry. M ... Full text Link to item Cite

APOE2 allele increased in tardive dyskinesia.

Journal Article Mov Disord · April 2006 Ninety-seven inpatients with tardive dyskinesia (average AIMS score = 13), the majority of whom were schizophrenic, were studied. Forty patients were Caucasian, and 57 were African-American. The APOE genotypes of these patients were compared to previously ... Full text Link to item Cite

Video/EEG monitoring in the evaluation of paroxysmal behavioral events: duration, effectiveness, and limitations.

Journal Article Epilepsy Behav · February 2006 To establish the number of monitoring days needed to distinguish psychogenic nonepileptic seizures (PNES) from epileptic seizures (ES) in adult patients admitted for video/EEG monitoring (VEM), we performed a retrospective chart review on 199 consecutive a ... Full text Link to item Cite

Friday night palsy: an unusual case of brachial plexus neuropathy.

Journal Article Clin Neurol Neurosurg · February 2006 Brachial plexopathy can result from traction injury, radiation injury, local or metastatic cancer, hereditary, or idiopathic causes. However, brachial plexopathy resulting from malposition of an arm during sleep, similar to Saturday night palsy, has not be ... Full text Link to item Cite

MNGIE neuropathy: five cases mimicking chronic inflammatory demyelinating polyneuropathy.

Journal Article Muscle Nerve · March 2004 We report five patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) who had demyelinating peripheral neuropathy. The MNGIE neuropathy had clinical and electrodiagnostic features typical of acquired, rather than inherited, etiologies. ... Full text Link to item Cite

The impact of bispectral index monitoring on rates of propofol administration.

Journal Article AACN Clin Issues · 2004 The purpose of this article is to examine the efficacy of Bispectral Index (BIS) monitoring as a tool for adjusting the amount of propofol patients receive to maintain a safe and adequate level of sedation in a neurocritical care setting. The BIS monitor i ... Full text Link to item Cite

APOE genotype is a risk factor for neuropathy severity in diabetic patients.

Journal Article Neurology · March 25, 2003 This cross-sectional study tested the hypothesis that APOE genotype is a risk factor for diabetic neuropathy severity. A model with age, duration of diabetes, and APOE genotype was found to predict (p = 0.0083) severity on the Neuropathy Impairment Score i ... Full text Link to item Cite

Guillain-Barre syndrome in organ and bone marrow transplant patients.

Journal Article Transplantation · April 27, 2001 BACKGROUND: Guillain-Barre Syndrome (GBS) is believed to be caused by autoimmune mechanisms that are predominantly T-cell mediated. We report GBS in organ transplant patients and bone marrow transplant patients, both of whom have iatrogenically suppressed ... Full text Link to item Cite

Use of specialized coagulation testing in the evaluation of patients with acute ischemic stroke.

Journal Article Neurology · March 13, 2001 OBJECTIVE: To investigate the use and appropriateness of specialized coagulation tests in the evaluation of patients with acute ischemic stroke and identify factors that influence test ordering. BACKGROUND: Coagulation abnormalities are a rare but recogniz ... Full text Link to item Cite

Apolipoprotein E and neuromuscular disease: a critical review of the literature.

Journal Article Arch Neurol · November 2000 Molecular mechanisms that alter the incidence and rate of neuromuscular disease progression are, in many cases, only partially understood. Several recent studies have asked whether apolipoprotein E (apoE for the protein, APOE for the gene) influences these ... Full text Link to item Cite

Cyclosporin A-related cerebral vasculopathy.

Journal Article Bone Marrow Transplant · October 2000 The use of cyclosporin A has been associated with several side-effects, including neurotoxicity. The mechanism of toxicity is not well known. We report two patients treated with cyclosporin A who developed lesions in the cerebral white matter associated wi ... Full text Link to item Cite

Ulnar nerve function following total elbow arthroplasty: a prospective study comparing preoperative and postoperative clinical and electrophysiologic evaluation in patients with rheumatoid arthritis.

Journal Article J Hand Surg Am · March 2000 A study was conducted to determine the incidence of ulnar and peripheral neuropathy in patients with rheumatoid arthritis undergoing total elbow arthroplasty and the effect it has on ulnar nerve function after surgery. Preoperative and postoperative clinic ... Full text Link to item Cite

Update on Alzheimer's disease. Promising advances in detection and treatment.

Journal Article Postgrad Med · October 15, 1999 In the past decade, significant progress has been made in the understanding and treatment of Alzheimer's disease. Modest success has been achieved using new drugs in treatment of mild symptoms of the disease. Vitamin E, estrogen, and NSAIDs may slow the pr ... Full text Link to item Cite

Managing common behavioral problems in dementia. How to improve quality of life for patients and families.

Journal Article Postgrad Med · October 15, 1999 Dementia is the most common reason for nursing home placement, and related behavioral symptoms are the primary factors precipitating the decision. Disruptive behaviors such as depression, sleep disturbance, agitation, aggression, and psychosis can tax fami ... Full text Link to item Cite

Determining the cause of memory loss in the elderly. From in-office screening to neuropsychological referral.

Journal Article Postgrad Med · October 15, 1999 Improved understanding of neurobehavior in normal aging, Alzheimer's disease, and late-life depression makes early detection of neurodegenerative conditions possible. Primary care physicians can screen patients' mental status and mood states with simple in ... Full text Link to item Cite

Initial evaluation of suspected dementia. Asking the right questions.

Journal Article Postgrad Med · October 15, 1999 The initial clinical approach to suspected dementia involves asking the right questions of the patient and a knowledgeable family member or caregiver. These questions should focus on the nature of the cognitive problem (e.g., the onset, duration, and sever ... Full text Link to item Cite

Dementia: A four-article symposium

Journal Article Postgraduate Medicine · October 15, 1999 Full text Cite

Electron microscopic diagnosis of human flavivirus encephalitis: use of confocal microscopy as an aid.

Journal Article Am J Surg Pathol · October 1999 The distinction between intracranial viral infections and inflammatory conditions requiring immunosuppression is important. Although specific laboratory reagents are readily available for some viruses, diagnosis of arbovirus infection is more difficult. Tr ... Full text Link to item Cite

Transient lumbosacral polyradiculopathy after prostatectomy: association with spinal stenosis.

Journal Article South Med J · August 1999 Mononeuropathies are common after pelvic surgery. They are usually the result of unnatural positioning during surgery or faulty restraining devices. Polyneuropathy in the postoperative setting is rare. We report two cases of polyradiculopathy after radical ... Full text Link to item Cite

Intravascular malignant lymphomatosis with neurologic presentation: factors facilitating antemortem diagnosis.

Journal Article South Med J · July 1998 Intravascular malignant lymphomatosis (IML) is a rare disorder of small and medium size vessels that frequently goes undiagnosed until the time of autopsy. The clinical courses of two such patients were examined to determine factors that would facilitate a ... Full text Link to item Cite

Concerns about meningitis.

Journal Article Postgrad Med · July 1998 Full text Link to item Cite

ELECTRON MICROSCOPIC DIAGNOSIS OF ARBOVIRAL MENINOOENCEPHALITIS

Journal Article Journal of Neuropathology and Experimental Neurology · May 1998 Full text Cite

Peripheral neuropathy and connective tissue disease. Watch for this twosome when hunting for a diagnosis.

Journal Article Postgrad Med · November 1997 Coexistent peripheral neuropathy and connective tissue disease is fairly common, possibly because immune-mediated factors are often present in both disorders. Awareness of the association between the two conditions can be important during diagnostic evalua ... Full text Link to item Cite

Surgical treatment of carpal tunnel syndrome in patients with peripheral neuropathy.

Journal Article Neurology · October 1997 Outcome after carpal tunnel surgery was studied retrospectively in 32 patients with peripheral neuropathy and carpal tunnel syndrome. Nocturnal paresthesias were almost universally relieved, followed in order of responsiveness by pain, numbness, and weakne ... Full text Link to item Cite

Peripheral neuropathy in patients with chronic renal failure. A treatable source of discomfort and disability.

Journal Article Postgrad Med · October 1997 Uremic polyneuropathy occurs in about half of patients undergoing dialysis and is characterized by axonal degeneration with secondary segmental demyelination. Hemodialysis or peritoneal dialysis halts the progress of polyneuropathy but usually does not bri ... Full text Link to item Cite

Endocrinologic causes of peripheral neuropathy. Pins and needles in a stocking-and-glove pattern and other symptoms.

Journal Article Postgrad Med · September 1997 In the Western world, diabetes is the biggest cause of peripheral neuropathy, usually distal symmetric polyneuropathy but some times another polyneuropathy or a focal neuropathy. In addition, hypothyroidism and acromegaly can cause carpal tunnel syndrome a ... Full text Link to item Cite

Recognizing peripheral neuropathy. How to read the clues to an underlying cause.

Journal Article Postgrad Med · September 1997 Several systemic diseases, including some common ones (eg, diabetes, rheumatoid arthritis, thyroid disease) can cause symptoms of peripheral nerve dysfunction. Efficient identification and treatment of the underlying disorder can avoid costly and unnecessa ... Full text Link to item Cite

A syndrome of concurrent central and peripheral nervous system involvement due to Epstein-Barr virus infection.

Journal Article Muscle Nerve · August 1996 Epstein-Barr virus infection can affect both the central and peripheral nervous system. In some patients this occurs concurrently. Two patients are presented with encephalopathy and acute quadriparesis with diminished reflexes. Positive serology for Epstei ... Full text Link to item Cite

Transcranial doppler sonography to monitor cerebral vasculitis.

Journal Article J Rheumatol · March 1996 We describe a patient with cerebral vasculitis treated with prednisone and cyclophosphamide and followed by serial transcranial Doppler sonography and arteriography. Proximal cerebral angiographic abnormalities correlated with transcranial Doppler abnormal ... Link to item Cite

Neuro-Behcet's disease in Japan - Reply

Journal Article NEUROLOGY · 1996 Full text Cite

Spontaneous vertebral dissection: clinical, conventional angiographic, CT, and MR findings.

Journal Article J Comput Assist Tomogr · 1996 OBJECTIVE: The purpose of this study was to determine if typical clinical and neuroradiologic patterns exist in patients with spontaneous vertebral artery (VA) dissection. MATERIALS AND METHODS: The medical records and neuroradiologic examinations of 14 pa ... Full text Link to item Cite

Neuro-Behçet's disease: factors hampering proper diagnosis.

Journal Article Neurology · September 1995 We reviewed the clinical course of nine patients with neuro-Behçet's disease to assess difficulties in making this diagnosis. Factors delaying proper diagnosis included lack of accurate history and physical examination, lack of recognition of an underlying ... Full text Link to item Cite

Spinal dysraphism and epidural anesthesia.

Journal Article Anesthesiology · September 1994 Full text Link to item Cite

Lumbar puncture and CSF examination. Answers to three commonly asked questions.

Journal Article Postgrad Med · June 1994 The incidence of post-lumbar puncture headache has been shown to be reduced by using a higher-gauge (smaller-bore) needle and orienting the needle bevel parallel to the dural fibers. Incidence of headache is the same in patients given bed rest as in patien ... Link to item Cite

Letters to the editor

Journal Article Muscle Nerve · January 1, 1994 Full text Cite

Bell's palsy: an eponym that often leads to confusion.

Journal Article Muscle Nerve · January 1994 Link to item Cite

EKG abnormalities in pediatric patients with myotonic dystrophy.

Journal Article Pediatr Neurol · 1993 Electrocardiographic (EKG) abnormalities are frequent in patients with myotonic dystrophy; cardiac complications may lead to significant morbidity and mortality. The charts of 17 pediatric patients with myotonic dystrophy were reviewed to ascertain the fre ... Full text Link to item Cite

Posey palsy.

Journal Article Ann Intern Med · November 1, 1992 Full text Link to item Cite

Myotonic dystrophy.

Journal Article Semin Neurol · September 1991 Full text Link to item Cite

Recurrent transient ischemic attacks and stroke in association with an internal carotid artery web.

Journal Article Stroke · January 1991 Fibromuscular dysplasia is a nonatherosclerotic vascular disease that most commonly affects cervical carotid arteries at the C1-C2 level when cephalic arteries are involved. Several histopathologic and angiographic subtypes of fibromuscular dysplasia exist ... Full text Link to item Cite

Bell's palsy. Ensuring the best possible outcome.

Journal Article Postgrad Med · October 1990 Bell's palsy is thought to be an idiopathic polyneuritis and must be distinguished from other disorders that cause facial weakness. In most cases, differentiation can be accomplished on the basis of the history, physical examination, and clinical course. R ... Full text Link to item Cite

Disc space infection: a case report with MRI diagnosis.

Journal Article Am Fam Physician · October 1990 Vertebral disc space infection is an uncommon cause of back pain. Physical findings may be unimpressive and laboratory evaluation may only disclose an elevated erythrocyte sedimentation rate. Magnetic resonance imaging is particularly useful, since it reve ... Link to item Cite

Disc space infection: a case report with MRI diagnosis.

Journal Article American family physician · October 1990 Vertebral disc space infection is an uncommon cause of back pain. Physical findings may be unimpressive and laboratory evaluation may only disclose an elevated erythrocyte sedimentation rate. Magnetic resonance imaging is particularly useful, since it reve ... Cite

Surgical treatment of cluster headache.

Journal Article J Neurosurg · June 1990 Cluster headache is ordinarily managed medically, but may become refractory to such medical management. In this setting, surgical treatment has occasionally been performed, based on evidence that pertinent pain pathways and parasympathetic pathways may be ... Full text Link to item Cite

Aspergillus disc space infection: case report and review of the literature.

Journal Article Neurosurgery · July 1989 Aspergillus disc space infection is an unusual complication of the immunocompromised state. Magnetic resonance imaging may aid the clinician in arriving at a prompt diagnosis of discitis in affected patients. We report a case of systemically acquired Asper ... Link to item Cite

496-Cyclic voltammetric studies on the application of carbon elctrodes in the determination of oxalic acid

Journal Article Journal of Electroanalytical Chemistry · January 1, 1982 The application of carbon paste and glassy carbon electrodes in the analysis of oxalic acid was investigated by comparing the characteristics of cyclic voltammograms of oxalic acid obtained in various supporting electrolytes (acetate, borate, citrate, phos ... Full text Cite

Cyclic voltammetric studies on the application of carbon electrodes in the determination of oxalic acid

Journal Article Bioelectrochemistry and Bioenergetics · January 1, 1982 The application of carbon paste and glassy carbon electrodes in the analysis of oxalic acid was investigated by comparing the characteristics of cyclic voltammograms of oxalic acid obtained in various supporting electrolytes (acetate, borate, citrate, phos ... Full text Cite