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Kate B Nooner

Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
601 South College Road, College of Science & Engineering, Wilmington, NC 28409

Selected Publications


Identifying high school risk factors that forecast heavy drinking onset in understudied young adults.

Journal Article Dev Cogn Neurosci · August 2024 Heavy alcohol drinking is a major, preventable problem that adversely impacts the physical and mental health of US young adults. Studies seeking drinking risk factors typically focus on young adults who enrolled in 4-year residential college programs (4YCP ... Full text Link to item Cite

How Do Anger and Impulsivity Impact Fast-Food Consumption in Transitional Age Youth?

Journal Article AJPM Focus · June 2024 INTRODUCTION: Consumption of fast food has been linked to psychiatric distress, violent behaviors, and impulsivity in adolescents. The relationship between eating fast food, anger, and impulsivity has not been widely investigated. The National Consortium o ... Full text Link to item Cite

Brain structural covariance network features are robust markers of early heavy alcohol use.

Journal Article Addiction · January 2024 BACKGROUND AND AIMS: Recently, we demonstrated that a distinct pattern of structural covariance networks (SCN) from magnetic resonance imaging (MRI)-derived measurements of brain cortical thickness characterized young adults with alcohol use disorder (AUD) ... Full text Link to item Cite

Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples.

Journal Article Dev Cogn Neurosci · October 2023 Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. Howe ... Full text Link to item Cite

Effects of emerging alcohol use on developmental trajectories of functional sleep measures in adolescents.

Journal Article Sleep · September 8, 2023 STUDY OBJECTIVES: Adolescence is characterized by significant brain development, accompanied by changes in sleep timing and architecture. It also is a period of profound psychosocial changes, including the initiation of alcohol use; however, it is unknown ... Full text Link to item Cite

The Link between Suicidality and Electroencephalography Asymmetry: A Systematic Review and Meta-analysis.

Journal Article Clin Psychopharmacol Neurosci · August 31, 2023 As one of the leading causes of death globally, suicide has been researched extensively to better understand factors that confer risk or resilience for suicidality. Promising areas of the literature have focused on brain-based factors that might indicate s ... Full text Link to item Cite

Changes in Electroencephalography Alpha Associated With Childhood Neglect and Adolescent Alcohol Use.

Journal Article Child Maltreat · May 2023 The present pilot study is interested in the relationship between childhood neglect, brain function, and alcohol use in adolescence. The goal is to guide future prevention and intervention efforts related to alcohol use following childhood neglect. This pi ... Full text Link to item Cite

Risk for depression tripled during the COVID-19 pandemic in emerging adults followed for the last 8 years.

Journal Article Psychol Med · April 2023 BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has significantly increased depression rates, particularly in emerging adults. The aim of this study was to examine longitudinal changes in depression risk before and during COVID-19 in a cohort ... Full text Link to item Cite

Adverse Childhood Experiences and Binge Drinking in Adolescence: the Role of Impulsivity and PTSD Symptoms.

Journal Article J Pediatr Neuropsychol · March 2023 BACKGROUND: The present study examines impulsivity and posttraumatic stress disorder (PTSD) symptoms as factors that may help understand the relationship between adverse childhood experiences (ACEs) and adolescent binge drinking. METHODS: Data were drawn f ... Full text Link to item Cite

Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach.

Journal Article Neuropsychopharmacology · January 2023 Cortical thickness changes dramatically during development and is associated with adolescent drinking. However, previous findings have been inconsistent and limited by region-of-interest approaches that are underpowered because they do not conform to the u ... Full text Link to item Cite

Earlier Bedtime and Effective Coping Skills Predict a Return to Low-Risk of Depression in Young Adults during the COVID-19 Pandemic.

Journal Article Int J Environ Res Public Health · August 18, 2022 To determine the persistent effects of the pandemic on mental health in young adults, we categorized depressive symptom trajectories and sought factors that promoted a reduction in depressive symptoms in high-risk individuals. Specifically, longitudinal an ... Full text Link to item Cite

Did the acute impact of the COVID-19 pandemic on drinking or nicotine use persist? Evidence from a cohort of emerging adults followed for up to nine years.

Journal Article Addict Behav · August 2022 OBJECTIVE: This study examined the impact of the COVID-19 pandemic on drinking and nicotine use through June of 2021 in a community-based sample of young adults. METHOD: Data were from 348 individuals (49% female) enrolled in a long-term longitudinal study ... Full text Link to item Cite

Prior test experience confounds longitudinal tracking of adolescent cognitive and motor development.

Journal Article BMC Med Res Methodol · June 24, 2022 BACKGROUND: Accurate measurement of trajectories in longitudinal studies, considered the gold standard method for tracking functional growth during adolescence, decline in aging, and change after head injury, is subject to confounding by testing experience ... Full text Link to item Cite

Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume.

Journal Article Cereb Cortex · June 7, 2022 The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though binge drinking is a health crisis among adolescents. The impact of binge drinking on gray matter volume (GMV) development was ... Full text Link to item Cite

Self-reported sleep and circadian characteristics predict alcohol and cannabis use: A longitudinal analysis of the National Consortium on Alcohol and Neurodevelopment in Adolescence Study.

Journal Article Alcohol Clin Exp Res · May 2022 BACKGROUND: Growing evidence indicates that sleep characteristics predict future substance use and related problems. However, most prior studies assessed a limited range of sleep characteristics, studied a narrow age span, and included few follow-up assess ... Full text Link to item Cite

Growth trajectories of cognitive and motor control in adolescence: How much is development and how much is practice?

Journal Article Neuropsychology · January 2022 ObjectiveExecutive control continues to develop throughout adolescence and is vulnerable to alcohol use. Although longitudinal assessment is ideal for tracking executive function development and onset of alcohol use, prior testing experience must ... Full text Cite

A Longitudinal Examination of Alcohol-Related Blackouts as a Predictor of Changes in Learning, Memory, and Executive Function in Adolescents.

Journal Article Frontiers in psychiatry · January 2022 IntroductionIn adolescents, the relationship between alcohol-related blackouts (ARBs) and distinct cognitive changes lasting beyond intoxication is unclear. We examined ARBs as a predictor of persistent changes in the development of learning, memo ... Full text Cite

Associations of developmental imbalance between sensation seeking and premeditation in adolescence and heavy episodic drinking in emerging adulthood.

Journal Article Alcohol Clin Exp Res · June 2021 BACKGROUND: Dual systems theories suggest that greater imbalance between higher reward sensitivity and lower cognitive control across adolescence conveys risk for behaviors such as heavy episodic drinking (HED). Prior research demonstrated that psychologic ... Full text Link to item Cite

Association of Heavy Drinking With Deviant Fiber Tract Development in Frontal Brain Systems in Adolescents.

Journal Article JAMA Psychiatry · April 1, 2021 IMPORTANCE: Maturation of white matter fiber systems subserves cognitive, behavioral, emotional, and motor development during adolescence. Hazardous drinking during this active neurodevelopmental period may alter the trajectory of white matter microstructu ... Full text Link to item Cite

Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.

Journal Article Addict Biol · March 2021 Exogenous causes, such as alcohol use, and endogenous factors, such as temperament and sex, can modulate developmental trajectories of adolescent neurofunctional maturation. We examined how these factors affect sexual dimorphism in brain functional network ... Full text Link to item Cite

Identifying high school risk factors that forecast heavy drinking onset in understudied young adults.

Journal Article Dev Cogn Neurosci · August 2024 Heavy alcohol drinking is a major, preventable problem that adversely impacts the physical and mental health of US young adults. Studies seeking drinking risk factors typically focus on young adults who enrolled in 4-year residential college programs (4YCP ... Full text Link to item Cite

How Do Anger and Impulsivity Impact Fast-Food Consumption in Transitional Age Youth?

Journal Article AJPM Focus · June 2024 INTRODUCTION: Consumption of fast food has been linked to psychiatric distress, violent behaviors, and impulsivity in adolescents. The relationship between eating fast food, anger, and impulsivity has not been widely investigated. The National Consortium o ... Full text Link to item Cite

Brain structural covariance network features are robust markers of early heavy alcohol use.

Journal Article Addiction · January 2024 BACKGROUND AND AIMS: Recently, we demonstrated that a distinct pattern of structural covariance networks (SCN) from magnetic resonance imaging (MRI)-derived measurements of brain cortical thickness characterized young adults with alcohol use disorder (AUD) ... Full text Link to item Cite

Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples.

Journal Article Dev Cogn Neurosci · October 2023 Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. Howe ... Full text Link to item Cite

Effects of emerging alcohol use on developmental trajectories of functional sleep measures in adolescents.

Journal Article Sleep · September 8, 2023 STUDY OBJECTIVES: Adolescence is characterized by significant brain development, accompanied by changes in sleep timing and architecture. It also is a period of profound psychosocial changes, including the initiation of alcohol use; however, it is unknown ... Full text Link to item Cite

The Link between Suicidality and Electroencephalography Asymmetry: A Systematic Review and Meta-analysis.

Journal Article Clin Psychopharmacol Neurosci · August 31, 2023 As one of the leading causes of death globally, suicide has been researched extensively to better understand factors that confer risk or resilience for suicidality. Promising areas of the literature have focused on brain-based factors that might indicate s ... Full text Link to item Cite

Changes in Electroencephalography Alpha Associated With Childhood Neglect and Adolescent Alcohol Use.

Journal Article Child Maltreat · May 2023 The present pilot study is interested in the relationship between childhood neglect, brain function, and alcohol use in adolescence. The goal is to guide future prevention and intervention efforts related to alcohol use following childhood neglect. This pi ... Full text Link to item Cite

Risk for depression tripled during the COVID-19 pandemic in emerging adults followed for the last 8 years.

Journal Article Psychol Med · April 2023 BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has significantly increased depression rates, particularly in emerging adults. The aim of this study was to examine longitudinal changes in depression risk before and during COVID-19 in a cohort ... Full text Link to item Cite

Adverse Childhood Experiences and Binge Drinking in Adolescence: the Role of Impulsivity and PTSD Symptoms.

Journal Article J Pediatr Neuropsychol · March 2023 BACKGROUND: The present study examines impulsivity and posttraumatic stress disorder (PTSD) symptoms as factors that may help understand the relationship between adverse childhood experiences (ACEs) and adolescent binge drinking. METHODS: Data were drawn f ... Full text Link to item Cite

Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach.

Journal Article Neuropsychopharmacology · January 2023 Cortical thickness changes dramatically during development and is associated with adolescent drinking. However, previous findings have been inconsistent and limited by region-of-interest approaches that are underpowered because they do not conform to the u ... Full text Link to item Cite

Earlier Bedtime and Effective Coping Skills Predict a Return to Low-Risk of Depression in Young Adults during the COVID-19 Pandemic.

Journal Article Int J Environ Res Public Health · August 18, 2022 To determine the persistent effects of the pandemic on mental health in young adults, we categorized depressive symptom trajectories and sought factors that promoted a reduction in depressive symptoms in high-risk individuals. Specifically, longitudinal an ... Full text Link to item Cite

Did the acute impact of the COVID-19 pandemic on drinking or nicotine use persist? Evidence from a cohort of emerging adults followed for up to nine years.

Journal Article Addict Behav · August 2022 OBJECTIVE: This study examined the impact of the COVID-19 pandemic on drinking and nicotine use through June of 2021 in a community-based sample of young adults. METHOD: Data were from 348 individuals (49% female) enrolled in a long-term longitudinal study ... Full text Link to item Cite

Prior test experience confounds longitudinal tracking of adolescent cognitive and motor development.

Journal Article BMC Med Res Methodol · June 24, 2022 BACKGROUND: Accurate measurement of trajectories in longitudinal studies, considered the gold standard method for tracking functional growth during adolescence, decline in aging, and change after head injury, is subject to confounding by testing experience ... Full text Link to item Cite

Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume.

Journal Article Cereb Cortex · June 7, 2022 The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though binge drinking is a health crisis among adolescents. The impact of binge drinking on gray matter volume (GMV) development was ... Full text Link to item Cite

Self-reported sleep and circadian characteristics predict alcohol and cannabis use: A longitudinal analysis of the National Consortium on Alcohol and Neurodevelopment in Adolescence Study.

Journal Article Alcohol Clin Exp Res · May 2022 BACKGROUND: Growing evidence indicates that sleep characteristics predict future substance use and related problems. However, most prior studies assessed a limited range of sleep characteristics, studied a narrow age span, and included few follow-up assess ... Full text Link to item Cite

Growth trajectories of cognitive and motor control in adolescence: How much is development and how much is practice?

Journal Article Neuropsychology · January 2022 ObjectiveExecutive control continues to develop throughout adolescence and is vulnerable to alcohol use. Although longitudinal assessment is ideal for tracking executive function development and onset of alcohol use, prior testing experience must ... Full text Cite

A Longitudinal Examination of Alcohol-Related Blackouts as a Predictor of Changes in Learning, Memory, and Executive Function in Adolescents.

Journal Article Frontiers in psychiatry · January 2022 IntroductionIn adolescents, the relationship between alcohol-related blackouts (ARBs) and distinct cognitive changes lasting beyond intoxication is unclear. We examined ARBs as a predictor of persistent changes in the development of learning, memo ... Full text Cite

Associations of developmental imbalance between sensation seeking and premeditation in adolescence and heavy episodic drinking in emerging adulthood.

Journal Article Alcohol Clin Exp Res · June 2021 BACKGROUND: Dual systems theories suggest that greater imbalance between higher reward sensitivity and lower cognitive control across adolescence conveys risk for behaviors such as heavy episodic drinking (HED). Prior research demonstrated that psychologic ... Full text Link to item Cite

Association of Heavy Drinking With Deviant Fiber Tract Development in Frontal Brain Systems in Adolescents.

Journal Article JAMA Psychiatry · April 1, 2021 IMPORTANCE: Maturation of white matter fiber systems subserves cognitive, behavioral, emotional, and motor development during adolescence. Hazardous drinking during this active neurodevelopmental period may alter the trajectory of white matter microstructu ... Full text Link to item Cite

Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.

Journal Article Addict Biol · March 2021 Exogenous causes, such as alcohol use, and endogenous factors, such as temperament and sex, can modulate developmental trajectories of adolescent neurofunctional maturation. We examined how these factors affect sexual dimorphism in brain functional network ... Full text Link to item Cite

Acceptability, Validity, and Engagement With a Mobile App for Frequent, Continuous Multiyear Assessment of Youth Health Behaviors (mNCANDA): Mixed Methods Study.

Journal Article JMIR Mhealth Uhealth · February 10, 2021 BACKGROUND: Longitudinal studies of many health behaviors often rely on infrequent self-report assessments. The measurement of psychoactive substance use among youth is expected to improve with more frequent mobile assessments, which can reduce recall bias ... Full text Link to item Cite

Acceptability, Validity, and Engagement With a Mobile App for Frequent, Continuous Multiyear Assessment of Youth Health Behaviors (mNCANDA): Mixed Methods Study (Preprint)

Journal Article · September 21, 2020 BACKGROUNDLongitudinal studies of many health behaviors often rely on infrequent self-report assessments. The measurement of psychoactive substance use among youth is expected to improve ... Full text Cite

Posttraumatic Stress Symptoms Predict Transition to Future Adolescent and Young Adult Moderate to Heavy Drinking in the NCANDA Sample.

Journal Article Curr Addict Rep · June 2020 PURPOSE OF STUDY: Approximately two thirds of youth report experiencing or witnessing a trauma. It is not known whether trauma or the posttraumatic stress symptoms (PTSS) following trauma increases adolescent drinking risk. RECENT FINDINGS: We described tr ... Full text Link to item Cite

Impact of Childhood Trauma on Executive Function in Adolescence-Mediating Functional Brain Networks and Prediction of High-Risk Drinking.

Journal Article Biol Psychiatry Cogn Neurosci Neuroimaging · May 2020 BACKGROUND: Childhood trauma is known to impart risk for several adverse life outcomes. Yet, its impact during adolescent development is not well understood. We aimed to investigate the relationships among childhood trauma, functional brain connectivity, e ... Full text Link to item Cite

Alpha EEG asymmetry, childhood maltreatment, and problem behaviors: A pilot home-based study.

Journal Article Child Abuse Negl · March 2020 BACKGROUND: Child maltreatment, trauma symptoms, and alpha electroencephalography (EEG) asymmetry have been linked to problem behaviors and alcohol use disorders. OBJECTIVE: The goal of this pilot study was to clarify the role of alpha EEG asymmetry in the ... Full text Link to item Cite

Longitudinal Impact of Life Events on Adolescent Binge Drinking in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA).

Journal Article Subst Use Misuse · 2020 Background: Life events experienced during adolescence are associated with risk and resilience to heavy episodic drinking (HED; i.e. binge drinking). The current study builds on prior research using latent class analysis (LCA) to examine heterogeneity in p ... Full text Link to item Cite

Retaining Adolescent and Young Adult Participants in Research During a Pandemic: Best Practices From Two Large-Scale Developmental Neuroimaging Studies (NCANDA and ABCD).

Journal Article Front Behav Neurosci · 2020 The novel coronavirus pandemic that emerged in late 2019 (COVID-19) has created challenges not previously experienced in human research. This paper discusses two large-scale NIH-funded multi-site longitudinal studies of adolescents and young adults - the N ... Full text Open Access Link to item Cite

A Pilot Study of Neurocognitive Function and Brain Structures in Adolescents With Alcohol Use Disorders: Does Maltreatment History Matter?

Journal Article Child Maltreat · November 2019 Neurocognitive and brain structural differences are associated with adolescent onset alcohol use disorders (AUDs). Maltreatment histories may contribute to current results. To examine these issues, healthy adolescents (n = 31), adolescents without maltreat ... Full text Open Access Link to item Cite

Depression in Maltreated Children and Adolescents.

Journal Article Child Adolesc Psychiatr Clin N Am · July 2019 Maltreatment affects 9.1 to 17.1 of every 1000 US children and adolescents. Maltreated youth are at high risk for depression. Clinicians should screen young patients for maltreatment history. Depressed maltreated youth are at high risk for treatment resist ... Full text Link to item Cite

A dimensional examination of eating disorder symptoms in relation to cognitive processing: An event-related potentials study

Journal Article Journal of Applied Biobehavioral Research · September 1, 2018 Identifying neurocognitive mechanisms involved in individuals experiencing eating disorder (ED) symptoms may be important for preventing EDs and improving rates of recovery. The present pilot study assessed how cognitive functioning may be associated with ... Full text Cite

An examination of sex differences on neurocognitive functioning and behavior problems in maltreated youth.

Journal Article Psychol Trauma · July 2018 OBJECTIVE: In the developmental traumatology model, the biological construct of sex is considered a moderator that may negatively influence child maltreatment sequelae including those pertaining to neurocognitive function. METHOD: This study examined sex-d ... Full text Link to item Cite

Brain Function Associated with Cooccurring Trauma and Depression Symptoms in College Students

Journal Article Journal of Aggression, Maltreatment and Trauma · February 7, 2017 The goal of this pilot study was to determine if functional brain differences are present among individuals with high and low cooccurring trauma and depression symptoms. This pilot study examined how the P300 latency component of event-related potentials ( ... Full text Cite

Adolescent Executive Dysfunction in Daily Life: Relationships to Risks, Brain Structure and Substance Use.

Journal Article Front Behav Neurosci · 2017 During adolescence, problems reflecting cognitive, behavioral and affective dysregulation, such as inattention and emotional dyscontrol, have been observed to be associated with substance use disorder (SUD) risks and outcomes. Prior studies have typically ... Full text Open Access Link to item Cite

The Role of Early Experience and Cognitive Vulnerability: Presenting a Unified Model of the Etiology of Panic

Journal Article Cognitive Therapy and Research · August 22, 2015 Cognitive vulnerability models have been developed to explicate the etiology of panic and other anxiety disorders. This study takes a step forward by presenting a unified vulnerability model that incorporates a continuum of proximal and distal factors invo ... Full text Open Access Cite

A Pilot Investigation of Media Multitasking and Trauma Symptoms Among Adolescents

Journal Article Journal of Human Behavior in the Social Environment · August 18, 2015 Effective prevention and intervention for trauma symptoms are still needed, particularly for adolescents, in whom high-risk behavior is common. This pilot study examines how media multitasking may be related to trauma symptoms in a sample of adolescent col ... Full text Cite

Relationship of trauma symptoms to amygdala-based functional brain changes in adolescents.

Journal Article J Trauma Stress · December 2013 In this pilot study, amygdala connectivity related to trauma symptoms was explored using resting-state functional magnetic resonance imaging (R-fMRI) in 23 healthy adolescents ages 13-17 years with no psychiatric diagnoses. Adolescents completed a self-rep ... Full text Open Access Link to item Cite

Factors related to posttraumatic stress disorder in adolescence.

Journal Article Trauma Violence Abuse · July 2012 Studies of posttraumatic stress disorder (PTSD) in adolescence published from 2000 to 2011 indicate that adolescents are at greater risk of experiencing trauma than either adults or children, and that the prevalence of PTSD among adolescents is 3-57%. Age, ... Full text Open Access Link to item Cite

Dimensional brain-behavior relationships in children with attention-deficit/hyperactivity disorder.

Journal Article Biol Psychiatry · March 1, 2012 BACKGROUND: Emerging neuroscientific and genetic findings emphasize the dimensional rather than the categorical aspects of psychiatric disorders. However, the integration of dimensional approaches within the current categorical diagnostic framework remains ... Full text Link to item Cite

The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry.

Journal Article Front Neurosci · 2012 The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls for an acceleration of discovery and the delineation of developmental trajectories for risk and resilience across the lifespan. To attain these objectives, ... Full text Open Access Link to item Cite

Family functioning and anxiety in school age children: The mediating role of control cognitions

Journal Article International Journal of Cognitive Therapy · December 1, 2010 As a test of the cognitive vulnerability model proposed by Chorpita and Barlow, the present study examined the mediating role of control beliefs on the relationship between family functioning and childhood anxiety. The sample was composed of 147 children a ... Full text Open Access Cite

Treatment for PTSD related to childhood abuse: a randomized controlled trial.

Journal Article Am J Psychiatry · August 2010 OBJECTIVE: Posttraumatic stress disorder (PTSD) related to childhood abuse is associated with features of affect regulation and interpersonal disturbances that substantially contribute to impairment. Existing treatments do not address these problems or the ... Full text Link to item Cite

Youth self-report of physical and sexual abuse: a latent class analysis.

Journal Article Child Abuse Negl · March 2010 OBJECTIVE: To determine if meaningful groups of at-risk pre-adolescent youth could be identified based on their self-report of physical and sexual abuse histories. METHODS: Youth participating in a consortium of ongoing longitudinal studies were interviewe ... Full text Link to item Cite

Parents' and teachers' concordance with children's self-ratings of suicidality: findings from a high-risk sample.

Journal Article Suicide Life Threat Behav · April 2006 This study examined concordance between adult and child reports of child suicidality using a sample of 1,046 8-year-old children at risk for, or having experienced, maltreatment. Concordance was low with both caregivers and teachers. For children reporting ... Full text Link to item Cite