Scholars@Duke
Kaveh Ardalan

Kaveh Ardalan

Assistant Professor of Pediatrics
Pediatrics, Rheumatology
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Selected Publications

Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework.

Journal Article Pediatr Rheumatol Online J · July 10, 2024 BACKGROUND: The American College of Rheumatology (ACR)/Childhood Arthritis and Rheumatology Research Alliance (CARRA) Mentoring Interest Group (AMIGO) is an inter-institutional mentorship program launched to target mentorship gaps within pediatric rheumato ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Link to item Cite

Mental health in paediatric and adult myositis-related diseases: current state of research, interventions, and future steps from the MIHRA Psychological Impact Scientific Working Group.

Journal Article Clin Exp Rheumatol · February 2024 Psychological and emotional well-being are critical aspects of overall health for individuals with chronic rheumatologic conditions. Mental health-related literature, however, predominantly focuses on systemic lupus erythematosus or rheumatoid arthritis, w ... Full text Link to item Cite

The impact of the COVID-19 pandemic on pediatric rheumatology practice: an international, cross-sectional survey study.

Journal Article Semin Arthritis Rheum · December 2023 OBJECTIVE: The COVID-19 pandemic has affected patient care in general. We aimed to analyze the impact of the pandemic on pediatric rheumatology practice. METHODS: An online survey including 22 questions was created by the representatives of the Emerging Rh ... Full text Link to item Cite

Cross-sectional quantitative validation of the paediatric Localized Scleroderma Quality of Life Instrument (LoSQI): A disease-specific patient-reported outcome measure.

Conference J Eur Acad Dermatol Venereol · July 2023 BACKGROUND: The Localized Scleroderma Quality of Life Instrument (LoSQI) is a disease-specific patient-reported outcome (PRO) measure designed for children and adolescents with localized scleroderma (LS; morphea). This tool was developed using rigorous PRO ... Full text Link to item Cite

Barriers to care in juvenile localized and systemic scleroderma: an exploratory survey study of caregivers' perspectives.

Journal Article Pediatr Rheumatol Online J · April 25, 2023 BACKGROUND: Juvenile localized scleroderma (LS) and systemic sclerosis (SSc) are rare pediatric conditions often associated with severe morbidities. Delays in diagnosis are common, increasing the risk for permanent damage and worse outcomes. This study exp ... Full text Link to item Cite

Comparison of Patient-Reported Outcomes Measurement Information System Computerized Adaptive Testing Versus Fixed Short Forms in Juvenile Myositis.

Journal Article Arthritis Care Res (Hoboken) · February 2023 OBJECTIVE: Patient-Reported Outcomes Measurement Information System (PROMIS) measures can be administered via computerized adaptive testing (CAT) or fixed short forms (FSFs), but the empirical benefits of CAT versus FSFs are unknown in juvenile myositis (J ... Full text Link to item Cite

The Effect of Psychiatric Comorbidity on Healthcare Utilization for Youth With Newly Diagnosed Systemic Lupus Erythematosus.

Journal Article J Rheumatol · February 2023 OBJECTIVE: To examine the effect of psychiatric diagnoses on healthcare use in youth with systemic lupus erythematosus (SLE) during their first year of SLE care. METHODS: We conducted a retrospective cohort study using claims from 2000 to 2013 from Clinfor ... Full text Link to item Cite

Cross-sectional characteristics of pediatric-onset discoid lupus erythematosus: Results of a multicenter, retrospective cohort study.

Journal Article J Am Acad Dermatol · September 2022 BACKGROUND: The incidence of systemic lupus in children with discoid lupus is unknown. OBJECTIVE: This study assessed the baseline characteristics of patients with pediatric discoid lupus erythematosus (pDLE). METHODS: Medical records at 17 sites were revi ... Full text Link to item Cite

Baseline characteristics of children with juvenile dermatomyositis enrolled in the first year of the new Childhood Arthritis and Rheumatology Research Alliance registry.

Journal Article Pediatr Rheumatol Online J · July 19, 2022 BACKGROUND: To report baseline characteristics, patient reported outcomes and treatment of children with Juvenile Dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. METHODS: Children newly diagnosed with J ... Full text Link to item Cite

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease.

Journal Article Arthritis Care Res (Hoboken) · April 2022 OBJECTIVE: To provide evidence-based recommendations and expert guidance for the management of Kawasaki disease (KD), focusing on clinical scenarios more commonly addressed by rheumatologists. METHODS: Sixteen clinical questions regarding diagnostic testin ... Full text Link to item Cite

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease.

Journal Article Arthritis Rheumatol · April 2022 OBJECTIVE: To provide evidence-based recommendations and expert guidance for the management of Kawasaki disease (KD), focusing on clinical scenarios more commonly addressed by rheumatologists. METHODS: Sixteen clinical questions regarding diagnostic testin ... Full text Link to item Cite

Cardiovascular Health in Pediatric Rheumatologic Diseases.

Journal Article Rheum Dis Clin North Am · February 2022 Cardiovascular disease risk is evident during childhood for patients with juvenile systemic lupus erythematosus, juvenile dermatomyositis, and juvenile idiopathic arthritis. The American Heart Association defines cardiovascular health as a positive health ... Full text Link to item Cite

International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis.

Journal Article Arthritis Rheumatol · February 2022 OBJECTIVE: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. METHODS: Parameters influencing cortico ... Full text Link to item Cite

Down Syndrome-Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes.

Conference Arthritis Care Res (Hoboken) · December 2021 OBJECTIVE: Down syndrome-associated arthritis (DA) is underrecognized, and current therapies used for juvenile idiopathic arthritis (JIA) appear to be poorly tolerated and less effective in patients with DA. The objective of this study was to characterize ... Full text Link to item Cite

Anxiety and depression in childhood rheumatologic conditions: A topical review

Journal Article Indian Journal of Rheumatology · September 1, 2021 This topical review summarizes recent literature on mental health symptoms experienced by children diagnosed with rheumatologic conditions including childhood-onset systemic lupus erythematosus (cSLE), juvenile idiopathic arthritis (JIA), and juvenile derm ... Full text Cite

Utility of patient-reported outcomes measurement information system (PROMIS) physical function form in inflammatory myopathy.

Journal Article Semin Arthritis Rheum · June 2021 OBJECTIVE: Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by muscle weakness, which limit activities of daily living. Patient Reported Outcomes Measurement Information System (PROMIS) is a set of outcome measures developed u ... Full text Link to item Cite

Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework.

Journal Article Pediatr Rheumatol Online J · July 10, 2024 BACKGROUND: The American College of Rheumatology (ACR)/Childhood Arthritis and Rheumatology Research Alliance (CARRA) Mentoring Interest Group (AMIGO) is an inter-institutional mentorship program launched to target mentorship gaps within pediatric rheumato ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Link to item Cite

Mental health in paediatric and adult myositis-related diseases: current state of research, interventions, and future steps from the MIHRA Psychological Impact Scientific Working Group.

Journal Article Clin Exp Rheumatol · February 2024 Psychological and emotional well-being are critical aspects of overall health for individuals with chronic rheumatologic conditions. Mental health-related literature, however, predominantly focuses on systemic lupus erythematosus or rheumatoid arthritis, w ... Full text Link to item Cite

The impact of the COVID-19 pandemic on pediatric rheumatology practice: an international, cross-sectional survey study.

Journal Article Semin Arthritis Rheum · December 2023 OBJECTIVE: The COVID-19 pandemic has affected patient care in general. We aimed to analyze the impact of the pandemic on pediatric rheumatology practice. METHODS: An online survey including 22 questions was created by the representatives of the Emerging Rh ... Full text Link to item Cite

Cross-sectional quantitative validation of the paediatric Localized Scleroderma Quality of Life Instrument (LoSQI): A disease-specific patient-reported outcome measure.

Conference J Eur Acad Dermatol Venereol · July 2023 BACKGROUND: The Localized Scleroderma Quality of Life Instrument (LoSQI) is a disease-specific patient-reported outcome (PRO) measure designed for children and adolescents with localized scleroderma (LS; morphea). This tool was developed using rigorous PRO ... Full text Link to item Cite

Barriers to care in juvenile localized and systemic scleroderma: an exploratory survey study of caregivers' perspectives.

Journal Article Pediatr Rheumatol Online J · April 25, 2023 BACKGROUND: Juvenile localized scleroderma (LS) and systemic sclerosis (SSc) are rare pediatric conditions often associated with severe morbidities. Delays in diagnosis are common, increasing the risk for permanent damage and worse outcomes. This study exp ... Full text Link to item Cite

Comparison of Patient-Reported Outcomes Measurement Information System Computerized Adaptive Testing Versus Fixed Short Forms in Juvenile Myositis.

Journal Article Arthritis Care Res (Hoboken) · February 2023 OBJECTIVE: Patient-Reported Outcomes Measurement Information System (PROMIS) measures can be administered via computerized adaptive testing (CAT) or fixed short forms (FSFs), but the empirical benefits of CAT versus FSFs are unknown in juvenile myositis (J ... Full text Link to item Cite

The Effect of Psychiatric Comorbidity on Healthcare Utilization for Youth With Newly Diagnosed Systemic Lupus Erythematosus.

Journal Article J Rheumatol · February 2023 OBJECTIVE: To examine the effect of psychiatric diagnoses on healthcare use in youth with systemic lupus erythematosus (SLE) during their first year of SLE care. METHODS: We conducted a retrospective cohort study using claims from 2000 to 2013 from Clinfor ... Full text Link to item Cite

Cross-sectional characteristics of pediatric-onset discoid lupus erythematosus: Results of a multicenter, retrospective cohort study.

Journal Article J Am Acad Dermatol · September 2022 BACKGROUND: The incidence of systemic lupus in children with discoid lupus is unknown. OBJECTIVE: This study assessed the baseline characteristics of patients with pediatric discoid lupus erythematosus (pDLE). METHODS: Medical records at 17 sites were revi ... Full text Link to item Cite

Baseline characteristics of children with juvenile dermatomyositis enrolled in the first year of the new Childhood Arthritis and Rheumatology Research Alliance registry.

Journal Article Pediatr Rheumatol Online J · July 19, 2022 BACKGROUND: To report baseline characteristics, patient reported outcomes and treatment of children with Juvenile Dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. METHODS: Children newly diagnosed with J ... Full text Link to item Cite

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease.

Journal Article Arthritis Care Res (Hoboken) · April 2022 OBJECTIVE: To provide evidence-based recommendations and expert guidance for the management of Kawasaki disease (KD), focusing on clinical scenarios more commonly addressed by rheumatologists. METHODS: Sixteen clinical questions regarding diagnostic testin ... Full text Link to item Cite

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease.

Journal Article Arthritis Rheumatol · April 2022 OBJECTIVE: To provide evidence-based recommendations and expert guidance for the management of Kawasaki disease (KD), focusing on clinical scenarios more commonly addressed by rheumatologists. METHODS: Sixteen clinical questions regarding diagnostic testin ... Full text Link to item Cite

Cardiovascular Health in Pediatric Rheumatologic Diseases.

Journal Article Rheum Dis Clin North Am · February 2022 Cardiovascular disease risk is evident during childhood for patients with juvenile systemic lupus erythematosus, juvenile dermatomyositis, and juvenile idiopathic arthritis. The American Heart Association defines cardiovascular health as a positive health ... Full text Link to item Cite

International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis.

Journal Article Arthritis Rheumatol · February 2022 OBJECTIVE: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. METHODS: Parameters influencing cortico ... Full text Link to item Cite

Down Syndrome-Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes.

Conference Arthritis Care Res (Hoboken) · December 2021 OBJECTIVE: Down syndrome-associated arthritis (DA) is underrecognized, and current therapies used for juvenile idiopathic arthritis (JIA) appear to be poorly tolerated and less effective in patients with DA. The objective of this study was to characterize ... Full text Link to item Cite

Anxiety and depression in childhood rheumatologic conditions: A topical review

Journal Article Indian Journal of Rheumatology · September 1, 2021 This topical review summarizes recent literature on mental health symptoms experienced by children diagnosed with rheumatologic conditions including childhood-onset systemic lupus erythematosus (cSLE), juvenile idiopathic arthritis (JIA), and juvenile derm ... Full text Cite

Utility of patient-reported outcomes measurement information system (PROMIS) physical function form in inflammatory myopathy.

Journal Article Semin Arthritis Rheum · June 2021 OBJECTIVE: Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by muscle weakness, which limit activities of daily living. Patient Reported Outcomes Measurement Information System (PROMIS) is a set of outcome measures developed u ... Full text Link to item Cite

Engaging patients and parents to improve mental health intervention for youth with rheumatological disease.

Conference Pediatr Rheumatol Online J · February 23, 2021 BACKGROUND: Mental health disorders are common in youth with rheumatological disease yet optimal intervention strategies are understudied in this population. We examined patient and parent perspectives on mental health intervention for youth with rheumatol ... Full text Link to item Cite

Parent Perspectives on Addressing Emotional Health for Children and Young Adults With Juvenile Myositis.

Journal Article Arthritis Care Res (Hoboken) · January 2021 OBJECTIVE: To assess parent perspectives regarding the emotional health impact of juvenile myositis (JM) on patients and families, and to assess preferences for emotional health screening and interventions. METHODS: Parents of children and young adults wit ... Full text Link to item Cite

The importance of development standards for anchoring vignettes: an illustrative example from pediatric localized scleroderma quality of life.

Journal Article Qual Life Res · December 2020 PURPOSE: Anchoring vignettes (AVs) are a promising measurement technique to reduce bias in patient-reported outcome (PRO) measures by helping researchers understand differences in how individuals and groups interpret response options. However, little atten ... Full text Link to item Cite

Adverse Childhood Experiences Are Associated with Childhood-Onset Arthritis in a National Sample of US Youth: An Analysis of the 2016 National Survey of Children's Health.

Journal Article J Pediatr · November 2020 OBJECTIVES: To determine whether there is an association between adverse childhood experiences (ACEs) and childhood-onset arthritis, comparing youth with arthritis to both healthy youth and youth with other acquired chronic physical diseases (OCPD); and to ... Full text Link to item Cite

Exploring the impact of paediatric localized scleroderma on health-related quality of life: focus groups with youth and caregivers.

Journal Article Br J Dermatol · October 2020 BACKGROUND: Paediatric localized scleroderma (LS) can negatively impact health-related quality of life (HRQoL) by causing skin fibrosis, abnormal limb development, disfigurement, and side-effects from immunosuppressive treatment. Studies to date have rarel ... Full text Link to item Cite

A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity.

Journal Article Br J Dermatol · March 2020 BACKGROUND: According to current standards, no existing patient-reported outcome (PRO) measures have high-quality validity evidence for use with individuals diagnosed with paediatric localized scleroderma (LS). This severely hinders patient-centred LS-focu ... Full text Open Access Link to item Cite

Recurrent Fever and Interstitial Lung Disease

Conference JOURNAL OF CLINICAL IMMUNOLOGY · 2020 Cite

Practice-based differences in paediatric discoid lupus erythematosus.

Journal Article Br J Dermatol · October 2019 BACKGROUND: Children with discoid lupus erythematosus (DLE) are at risk for disfigurement and progression to systemic lupus erythematosus (SLE). Consensus is lacking regarding optimal care for children with DLE. OBJECTIVES: The aim of this study was to com ... Full text Link to item Cite

Research priorities in childhood-onset lupus: results of a multidisciplinary prioritization exercise.

Journal Article Pediatr Rheumatol Online J · July 1, 2019 BACKGROUND: Childhood-onset systemic erythematosus lupus (cSLE) is characterized by more severe disease, widespread organ involvement and higher mortality compared to adult-onset SLE. However, cSLE is largely underfunded to carry out necessary research to ... Full text Link to item Cite

Evaluation of the reliability and validity of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) in paediatric cutaneous lupus among paediatric dermatologists and rheumatologists.

Journal Article Br J Dermatol · January 2019 BACKGROUND: The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) is a reliable outcome measure for cutaneous lupus erythematosus (CLE) in adults used in clinical trials. However, it has not been validated in children, limiting clinical ... Full text Link to item Cite

Inpatient burden of juvenile dermatomyositis among children in the United States.

Journal Article Pediatr Rheumatol Online J · November 13, 2018 BACKGROUND: Juvenile dermatomyositis (JDM) is a rare autoimmune disease that causes significant morbidity and quality of life impairment. Little is known about the inpatient burden of JDM in the US. Our goal was to determine the prevalence and risk factors ... Full text Link to item Cite

Physical Function Trajectories in Children with Juvenile Myositis

Conference ARTHRITIS & RHEUMATOLOGY · September 1, 2018 Link to item Cite

Psychometric properties of the Children's Dermatology Life Quality Index in pediatric localized scleroderma.

Journal Article J Scleroderma Relat Disord · June 2018 INTRODUCTION: The Children's Dermatology Life Quality Index has been used to measure quality of life in studies of pediatric localized scleroderma, which suggested only modest effects on quality of life. However, the Children's Dermatology Life Quality Ind ... Full text Link to item Cite

Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample.

Journal Article Rheumatology (Oxford) · April 1, 2018 OBJECTIVE: JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is k ... Full text Link to item Cite

Morphea (Localized scleroderma)

Chapter · January 1, 2018 Cite

Longitudinal Predictors of Physical Function in Juvenile Myositis

Conference ARTHRITIS & RHEUMATOLOGY · October 1, 2017 Link to item Cite

Predictors of Hospitalization, Length of Stay, and Cost of Care Among Adults With Dermatomyositis in the United States.

Conference Arthritis Care Res (Hoboken) · September 2017 OBJECTIVE: To determine the prevalence and risk factors for hospitalization with dermatomyositis and assess inpatient burden of dermatomyositis. METHODS: Data on 72,651,487 hospitalizations from the 2002-2012 Nationwide Inpatient Sample, a 20% stratified s ... Full text Link to item Cite

Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma.

Journal Article Arthritis Care Res (Hoboken) · July 2017 OBJECTIVE: Localized scleroderma can negatively affect children's quality of life (QoL), but predictors of impact have not been well described. We sought to identify predictors of QoL impact in juvenile localized scleroderma patients. METHODS: We analyzed ... Full text Link to item Cite

Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America.

Journal Article Pediatr Rheumatol Online J · June 13, 2017 BACKGROUND: The prognosis of children with juvenile dermatomyositis (JDM) has improved remarkably since the 1960's with the use of corticosteroid and immunosuppressive therapy. Yet there remain a minority of children who have refractory disease. Since 2003 ... Full text Link to item Cite

176 Inpatient burden of dermatomyositis in united states adults

Conference Journal of Investigative Dermatology · May 2017 Full text Cite

Validation of International Classification of Diseases Codes for the Epidemiologic Study of Dermatomyositis.

Journal Article Arthritis Care Res (Hoboken) · May 2017 OBJECTIVE: To assess the validity of using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 710.3 to identify adult patients with dermatomyositis in outpatient and inpatient settings. METHODS: Electronic medic ... Full text Link to item Cite

Postoperative spinal fusion care in pediatric patients: Co-management decreases length of stay.

Journal Article Bull Hosp Jt Dis (2013) · 2014 BACKGROUND: Standardized pediatric hospitalist and orthopaedic co-management of spinal fusion patients may improve quality processes and outcomes. This approach has not been studied in a general academic center. OBJECTIVE: Estimate relative effects and fea ... Link to item Cite

Real world use of an Internet intervention for pediatric encopresis.

Journal Article J Med Internet Res · June 30, 2008 BACKGROUND: The Internet is a significant source of medical information and is now being shown to be an important conduit for delivering various health-related interventions. OBJECTIVE: This paper aimed to examine the utility and impact of an Internet inte ... Full text Link to item Cite