Scholars@Duke
Kenneth Gregory Morris

Kenneth Gregory Morris

Associate Professor of Medicine
Medicine, Cardiology
kenneth.morris@duke.edu
A3002 VA Med Ctr 111A, 508 Fulton St, Durham, NC
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Selected Publications

Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomised study.

Journal Article Lancet · July 16, 2005 BACKGROUND: Data from a pilot study suggested that noetic therapies-healing practices that are not mediated by tangible elements-can reduce preprocedural distress and might affect outcomes in patients undergoing percutaneous coronary intervention. We under ... Full text Link to item Cite

Correlations between preprocedure mood and clinical outcome in patients undergoing coronary angioplasty.

Journal Article Cardiol Rev · 2003 We studied the relationship between mood and mood shift immediately before percutaneous coronary intervention (PCI) and 3 end points: total ischemic burden during PCI, adverse cardiac end points (ACE) after PCI, and death by 6-month follow up. Patients (n ... Full text Link to item Cite

Integrative noetic therapies as adjuncts to percutaneous intervention during unstable coronary syndromes: Monitoring and Actualization of Noetic Training (MANTRA) feasibility pilot.

Journal Article Am Heart J · November 2001 BACKGROUND: Patients undergoing percutaneous coronary intervention (PCI) for unstable coronary syndromes have substantial emotional and spiritual distress that may promote procedural complications. Noetic (nonpharmacologic) therapies may reduce anxiety, pa ... Full text Link to item Cite

Spinal-flexibility-plus-aerobic versus aerobic-only training: effect of a randomized clinical trial on function in at-risk older adults.

Journal Article J Gerontol A Biol Sci Med Sci · July 1999 BACKGROUND: As exercise is associated with favorable health outcomes, impaired older adults may benefit from specialized exercise interventions to achieve gains in function. The purpose of this study was to determine the added benefit of a spinal flexibili ... Full text Link to item Cite

Lossy (15:1) JPEG compression of digital coronary angiograms does not limit detection of subtle morphological features.

Journal Article Circulation · August 19, 1997 BACKGROUND: Development of the "all-digital" cardiac catheterization laboratory has been slowed by substantial computer archival and transfer requirements. Lossy data compression reduces this burden but creates irreversible changes in images, potentially i ... Full text Link to item Cite

Compression of digital coronary angiograms does not affect visual or quantitative assessment of coronary artery stenosis severity.

Journal Article Am J Cardiol · July 15, 1996 Digital coronary angiographic techniques are now widely used in many cardiac catheterization laboratories. However, the full potential of digital imaging technology remains to be achieved because of its enormous storage and exchange requirements. Compressi ... Full text Link to item Cite

Impact of an interactive video on decision making of patients with ischemic heart disease.

Journal Article J Gen Intern Med · June 1996 An experimental pilot study using repeated measures to examine the impact of an interactive video program on the decision making of patients with ischemic heart disease was carried on at a tertiary care center and a Veterans Affairs hospital. The patients ... Full text Link to item Cite

Application of quantitative coronary angiography in a cineless environment: in vivo assessment of a fully automated system for clinical use.

Journal Article Am Heart J · February 1995 The accuracy and precision of a fully automated quantitative coronary angiography (QCA) algorithm for use in a cineless environment were determined in phantom studies and in an in vivo canine preparation. Imaging studies of 118 coronary segments in six ane ... Full text Link to item Cite

Postmortem validation of the automated coronary analysis (ACA) software package.

Journal Article Int J Card Imaging · June 1994 Goal of this study was to compare the quantitative coronary arteriographic (QCA) results obtained with the Philips DCI/ACA analytical software package with those from postmortem casts in an animal experimental setting. Standard digital coronary arteriogram ... Full text Link to item Cite

An image processing algorithm for the determination of changes in coronary blood flow from digital coronary angiograms

Journal Article Computers in Cardiology · May 1, 1991 A method for measuring regional variation in coronary blood flow has been developed using image processing techniques applied to sequences of digital coronary angiograms. A series of digital subtraction angiography images is used as a basic data set to for ... Cite

Quantitative analysis of cardiac images: Application in the clinical environment

Journal Article MedicaMundi · January 1, 1991 This article describes the application of quantitative cardiac analysis in a high volume clinical environment. Computerized evaluation is applied for measurement of coronary artery stenoses, and for determination of global and regional ventricular function ... Cite

Multiuser environment for the display and processing of digital cardiac angiographic images

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1990 The increased application of digital imaging techniques to diagnostic cardiology requires the resolution of several remaining problems involving the transmission, display and storage of clinical image data. A Digital Imaging Laboratory is being assembled f ... Cite

Randomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiography.

Journal Article J Am Coll Cardiol · October 1990 To evaluate the effectiveness and cost of low osmolarity, nonionic contrast agents for cardiac angiography, 443 patients were randomized to receive either iopamidol or diatrizoate. All adverse events that occurred within 24 h of the procedure were recorded ... Full text Link to item Cite

Effects of atrial natriuretic peptide on the coronary arterial vasculature in humans.

Journal Article Circulation · December 1989 The effects of the synthetic 28-amino-acid alpha-human atrial natriuretic peptide (ANP) on the proximal coronary arteries and coronary blood flow were evaluated in 17 patients. Proximal coronary dimension was quantitated by digital angiography, and coronar ... Full text Link to item Cite

Contrast nephrotoxicity.

Journal Article N Engl J Med · August 10, 1989 Full text Link to item Cite

Contrast nephrotoxicity: a randomized controlled trial of a nonionic and an ionic radiographic contrast agent.

Journal Article N Engl J Med · January 19, 1989 Experimental studies have suggested that nonionic contrast agents are less nephrotoxic than ionic contrast agents. To examine the relative nephrotoxicity of the two types of agents, we randomly assigned 443 patients to receive either iopamidol (nonionic) o ... Full text Link to item Cite

Chronic stable angina monotherapy. Nifedipine versus propranolol.

Journal Article Am J Med · January 16, 1989 A placebo-controlled, double-blind, crossover study was conducted to determine the effects of nifedipine (60 to 90 mg per day) monotherapy and propranolol (240 mg per day) monotherapy on symptoms, angina threshold, and cardiac function in patients with chr ... Full text Link to item Cite

Cardiovascular and renal toxicity of a nonionic radiographic contrast agent after cardiac catheterization. A prospective trial.

Journal Article Ann Intern Med · January 15, 1989 STUDY OBJECTIVE: To determine the incidence of cardiovascular and renal toxicity of a nonionic contrast agent when used for cardiac catheterization, and to assess the value of electrolytes and urinalysis results as predictors of nephropathy induced by a co ... Full text Link to item Cite

Clinical chemistry outside laboratories: report of a second survey.

Journal Article Med Lab Sci · January 1989 The growth in the use of small portable analysers outside hospital laboratories has been a cause of concern to laboratory practitioners. This has been partly because of a perceived threat to laboratory careers and partly because of fears that the quality o ... Link to item Cite

Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomised study.

Journal Article Lancet · July 16, 2005 BACKGROUND: Data from a pilot study suggested that noetic therapies-healing practices that are not mediated by tangible elements-can reduce preprocedural distress and might affect outcomes in patients undergoing percutaneous coronary intervention. We under ... Full text Link to item Cite

Correlations between preprocedure mood and clinical outcome in patients undergoing coronary angioplasty.

Journal Article Cardiol Rev · 2003 We studied the relationship between mood and mood shift immediately before percutaneous coronary intervention (PCI) and 3 end points: total ischemic burden during PCI, adverse cardiac end points (ACE) after PCI, and death by 6-month follow up. Patients (n ... Full text Link to item Cite

Integrative noetic therapies as adjuncts to percutaneous intervention during unstable coronary syndromes: Monitoring and Actualization of Noetic Training (MANTRA) feasibility pilot.

Journal Article Am Heart J · November 2001 BACKGROUND: Patients undergoing percutaneous coronary intervention (PCI) for unstable coronary syndromes have substantial emotional and spiritual distress that may promote procedural complications. Noetic (nonpharmacologic) therapies may reduce anxiety, pa ... Full text Link to item Cite

Spinal-flexibility-plus-aerobic versus aerobic-only training: effect of a randomized clinical trial on function in at-risk older adults.

Journal Article J Gerontol A Biol Sci Med Sci · July 1999 BACKGROUND: As exercise is associated with favorable health outcomes, impaired older adults may benefit from specialized exercise interventions to achieve gains in function. The purpose of this study was to determine the added benefit of a spinal flexibili ... Full text Link to item Cite

Lossy (15:1) JPEG compression of digital coronary angiograms does not limit detection of subtle morphological features.

Journal Article Circulation · August 19, 1997 BACKGROUND: Development of the "all-digital" cardiac catheterization laboratory has been slowed by substantial computer archival and transfer requirements. Lossy data compression reduces this burden but creates irreversible changes in images, potentially i ... Full text Link to item Cite

Compression of digital coronary angiograms does not affect visual or quantitative assessment of coronary artery stenosis severity.

Journal Article Am J Cardiol · July 15, 1996 Digital coronary angiographic techniques are now widely used in many cardiac catheterization laboratories. However, the full potential of digital imaging technology remains to be achieved because of its enormous storage and exchange requirements. Compressi ... Full text Link to item Cite

Impact of an interactive video on decision making of patients with ischemic heart disease.

Journal Article J Gen Intern Med · June 1996 An experimental pilot study using repeated measures to examine the impact of an interactive video program on the decision making of patients with ischemic heart disease was carried on at a tertiary care center and a Veterans Affairs hospital. The patients ... Full text Link to item Cite

Application of quantitative coronary angiography in a cineless environment: in vivo assessment of a fully automated system for clinical use.

Journal Article Am Heart J · February 1995 The accuracy and precision of a fully automated quantitative coronary angiography (QCA) algorithm for use in a cineless environment were determined in phantom studies and in an in vivo canine preparation. Imaging studies of 118 coronary segments in six ane ... Full text Link to item Cite

Postmortem validation of the automated coronary analysis (ACA) software package.

Journal Article Int J Card Imaging · June 1994 Goal of this study was to compare the quantitative coronary arteriographic (QCA) results obtained with the Philips DCI/ACA analytical software package with those from postmortem casts in an animal experimental setting. Standard digital coronary arteriogram ... Full text Link to item Cite

An image processing algorithm for the determination of changes in coronary blood flow from digital coronary angiograms

Journal Article Computers in Cardiology · May 1, 1991 A method for measuring regional variation in coronary blood flow has been developed using image processing techniques applied to sequences of digital coronary angiograms. A series of digital subtraction angiography images is used as a basic data set to for ... Cite

Quantitative analysis of cardiac images: Application in the clinical environment

Journal Article MedicaMundi · January 1, 1991 This article describes the application of quantitative cardiac analysis in a high volume clinical environment. Computerized evaluation is applied for measurement of coronary artery stenoses, and for determination of global and regional ventricular function ... Cite

Multiuser environment for the display and processing of digital cardiac angiographic images

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1990 The increased application of digital imaging techniques to diagnostic cardiology requires the resolution of several remaining problems involving the transmission, display and storage of clinical image data. A Digital Imaging Laboratory is being assembled f ... Cite

Randomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiography.

Journal Article J Am Coll Cardiol · October 1990 To evaluate the effectiveness and cost of low osmolarity, nonionic contrast agents for cardiac angiography, 443 patients were randomized to receive either iopamidol or diatrizoate. All adverse events that occurred within 24 h of the procedure were recorded ... Full text Link to item Cite

Effects of atrial natriuretic peptide on the coronary arterial vasculature in humans.

Journal Article Circulation · December 1989 The effects of the synthetic 28-amino-acid alpha-human atrial natriuretic peptide (ANP) on the proximal coronary arteries and coronary blood flow were evaluated in 17 patients. Proximal coronary dimension was quantitated by digital angiography, and coronar ... Full text Link to item Cite

Contrast nephrotoxicity.

Journal Article N Engl J Med · August 10, 1989 Full text Link to item Cite

Contrast nephrotoxicity: a randomized controlled trial of a nonionic and an ionic radiographic contrast agent.

Journal Article N Engl J Med · January 19, 1989 Experimental studies have suggested that nonionic contrast agents are less nephrotoxic than ionic contrast agents. To examine the relative nephrotoxicity of the two types of agents, we randomly assigned 443 patients to receive either iopamidol (nonionic) o ... Full text Link to item Cite

Chronic stable angina monotherapy. Nifedipine versus propranolol.

Journal Article Am J Med · January 16, 1989 A placebo-controlled, double-blind, crossover study was conducted to determine the effects of nifedipine (60 to 90 mg per day) monotherapy and propranolol (240 mg per day) monotherapy on symptoms, angina threshold, and cardiac function in patients with chr ... Full text Link to item Cite

Cardiovascular and renal toxicity of a nonionic radiographic contrast agent after cardiac catheterization. A prospective trial.

Journal Article Ann Intern Med · January 15, 1989 STUDY OBJECTIVE: To determine the incidence of cardiovascular and renal toxicity of a nonionic contrast agent when used for cardiac catheterization, and to assess the value of electrolytes and urinalysis results as predictors of nephropathy induced by a co ... Full text Link to item Cite

Clinical chemistry outside laboratories: report of a second survey.

Journal Article Med Lab Sci · January 1989 The growth in the use of small portable analysers outside hospital laboratories has been a cause of concern to laboratory practitioners. This has been partly because of a perceived threat to laboratory careers and partly because of fears that the quality o ... Link to item Cite

Survival and cardiac event rates in the first year after emergency coronary angioplasty for acute myocardial infarction.

Journal Article J Am Coll Cardiol · June 1988 One year survival and event-free survival rates were analyzed in 342 patients with acute myocardial infarction who were consecutively enrolled in a treatment protocol of early intravenous thrombolytic therapy followed by emergency coronary angioplasty. Nin ... Full text Link to item Cite

Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase.

Journal Article Circulation · January 1988 Two hundred and sixteen patients with acute myocardial infarction were treated with immediate infusion of high-dose (1.5 million units) intravenous streptokinase followed by emergency coronary angioplasty. The infarct lesion was crossed and dilated in 99% ... Full text Link to item Cite

Hemodynamic effects of intravenous pirmenol

Journal Article Angiology · January 1, 1988 The hemodynamic effects of intravenous pirmenol were studied in 21 subjects instrumented with peripheral arterial, pulmonary artery, and left ventricular catheters. Baseline measurements of heart rate, cardiac output, pulmonary artery pressure, systemic ar ... Cite

A perspective: Designing the all digital cardiac catheterization laboratory

Journal Article American Journal of Cardiac Imaging · January 1, 1988 Cite

Digital subtraction angiography in angioplasty of total coronary artery occlusion.

Journal Article Chest · September 1987 This report describes a digital subtraction angiographic technique used to simultaneously display the proximal and distal segments of three totally occluded coronary arteries in two patients undergoing percutaneous transluminal coronary angioplasty (PTCA). ... Full text Link to item Cite

Recovery of systolic and diastolic left ventricular function after a 60-second coronary arterial occlusion during percutaneous transluminal coronary angioplasty for angina pectoris.

Journal Article Am J Cardiol · September 1, 1987 Recovery of global and regional systolic and global diastolic left ventricular (LV) function was examined after 60 seconds of coronary arterial occlusion in 9 men without myocardial infarction undergoing elective percutaneous transluminal coronary angiopla ... Full text Link to item Cite

Relation between myocardial perfusion and left ventricular function following acute coronary occlusion: disproportionate effects of anterior vs. inferior ischemia.

Journal Article Circ Res · January 1987 This study examined the relation between left ventricular (LV) function and the severity of acute myocardial ischemia in a conscious dog model. The LV ejection fraction (EF) was measured by multigated equilibrium radionuclide angiography, and regional myoc ... Full text Link to item Cite

Physiologic basis for the age-related decline in aerobic work capacity.

Journal Article Am J Cardiol · June 1, 1986 To determine the physiologic mechanisms of the decline in aerobic work performance with age, a cross-sectional study was performed. Twenty-four sedentary male volunteers, aged 20 to 50 years, underwent right-sided cardiac catheterization, arterial cannulat ... Full text Link to item Cite

Comparison of nifedipine alone with propranolol alone for stable angina pectoris including hemodynamics at rest and during exercise.

Journal Article Am J Cardiol · May 1, 1986 The effects of nifedipine (60 to 90 mg/day) and propranolol (240 mg/day) on symptoms, angina threshold and cardiac function were compared in a placebo-controlled, double-blind, crossover study. Five-week treatment periods with nifedipine and propranolol we ... Full text Link to item Cite

Value and limitation of biplane rest and exercise radionuclide angiography for assessing individual bypass grafts: a prospective study.

Journal Article J Am Coll Cardiol · May 1986 This prospective study evaluated the ability of serial biplane rest and exercise radionuclide angiography to predict the status of individual coronary bypass grafts in 20 patients 2 to 6 months after surgery. The preoperative coronary angiogram was used to ... Full text Link to item Cite

Regulation of stroke volume during submaximal and maximal upright exercise in normal man.

Journal Article Circ Res · February 1986 To characterize the hemodynamic factors that regulate stroke volume during upright exercise in normal man, 24 asymptomatic male volunteers were evaluated by simultaneous right heart catheterization, radionuclide angiography, and expired gas analysis during ... Full text Link to item Cite

Left ventricular ejection fraction after acute coronary occlusion in conscious dogs: relation to the extent and site of myocardial infarction.

Journal Article Circulation · September 1985 The change in left ventricular radionuclide ejection fraction after acute occlusion of the left anterior descending (LAD) or circumflex (LC) coronary artery was compared with the ultimate histologic extent of myocardial infarction in conscious dogs. The ac ... Full text Link to item Cite

Value of radionuclide angiography for predicting specific cardiac events after acute myocardial infarction.

Journal Article Am J Cardiol · February 1, 1985 The value of rest and exercise radionuclide angiography (RNA) for predicting specific events including death, recurrent acute myocardial infarction (AMI), coronary care unit readmission for unstable chest pain, and medically refractory angina after AMI was ... Full text Link to item Cite

Sex-related differences in the normal cardiac response to upright exercise.

Journal Article Circulation · September 1984 In previous studies from this laboratory, we found that approximately 30% of women with chest pain and normal coronary arteries demonstrated either a decrease in or a failure to increase radionuclide ejection fraction during exercise. To examine the hypoth ... Full text Link to item Cite

Assessment of regional left ventricular function using gated radionuclide angiography.

Journal Article Am J Cardiol · August 1, 1984 A simple method for the assessment of regional left ventricular (LV) function using gated radionuclide angiography is described. The method divides the LV region of interest in the left anterior oblique view into quadrants using a count-weighted center poi ... Full text Link to item Cite

Clinical characteristics and long-term survival of patients with variant angina.

Journal Article Circulation · May 1984 We studied 109 consecutive patients with variant angina who underwent cardiac catheterization over an 11 year period. All patients were followed for at least 6 months or until death, and 46 patients (22 treated medically and 24 treated surgically) were fol ... Full text Link to item Cite

Relation between radionuclide angiographic regional ejection fraction and left ventricular regional ischemia in awake dogs.

Journal Article Am J Cardiol · January 15, 1984 Multigated equilibrium radionuclide angiography was used to quantitate global and regional ejection fraction (EF) in 26 awake dogs 10 minutes after distal and then proximal occlusion of the left anterior descending (LAD) or left circumflex (LC) coronary ar ... Full text Link to item Cite

Comparison of high-dose and medium-dose propranolol in the relief of exercise-induced myocardial ischemia.

Journal Article Am J Cardiol · July 1983 The effects of medium-dose (160 mg/day) and high-dose (480 mg/day) oral propranolol were compared in 22 patients who had typical angina pectoris and objective evidence of myocardial ischemia during exercise. Left ventricular (LV) ejection fraction (EF) and ... Full text Link to item Cite

Effect of rate-dependent left bundle branch block on global and regional left ventricular function.

Journal Article Circulation · May 1983 Seven subjects with rate-dependent left bundle branch block (RDLBBB) and 13 subjects with normal conduction (control group) underwent upright bicycle exercise radionuclide angiography to determine the effects of the development of RDLBBB on global and regi ... Full text Link to item Cite

Determinants of variable exercise performance among patients with severe left ventricular dysfunction.

Journal Article Am J Cardiol · January 1, 1983 The relation between bicycle exercise performance and determinants of central and peripheral cardiovascular function was assessed in 17 patients with class II to III heart failure and in 9 normal subjects. Proportional changes in oxygen consumption (VO2) f ... Full text Link to item Cite

Hemodynamic effects of the antiarrhythmic drug pirmenol.

Journal Article Clin Pharmacol Ther · August 1982 We examined the hemodynamic effects of pirmenol, a new antiarrhythmic drug, for the first time in man. Right and left heart pressures, Fick cardiac output, and radionuclide ejection fraction were measured before and during infusion of pirmenol in 10 patien ... Full text Link to item Cite

Subvalvular thrombotic obstruction of an aortic porcine heterograft.

Journal Article Chest · June 1982 A 48-year-old man had angina pectoris and symptoms of heart failure. Cardiac catheterization showed severe aortic stenosis and regurgitation, and he underwent aortic valve replacement in 1976 with a 23-mm Carpentier-Edwards aortic porcine heterograft. Init ... Full text Link to item Cite

A QRS scoring system for assessing left ventricular function after myocardial infarction.

Journal Article N Engl J Med · January 7, 1982 A QRS scoring system for estimating the size of a myocardial infarct was evaluated in 55 patients who did not have left ventricular hypertrophy or conduction abnormalities. Serial 12-lead surface electrocardiograms were scored according to a 29-point syste ... Full text Link to item Cite

Criteria for early discharge after acute myocardial infarction: validation in a community hospital.

Journal Article Arch Intern Med · January 1982 All patients admitted to a community hospital coronary care unit during an 18-month-period were studied to validate previously reported criteria for early hospital discharge after myocardial infarction. Factors present during the first four hospital days, ... Link to item Cite

Comparison of multigated radionuclide angiography with ultrasonic sonomicrometry over a wide range of ventricular function in the conscious dog.

Journal Article Am J Cardiol · December 1, 1980 This study compared the noninvasive assessment of left ventricular function with radionuclide angiography with that obtained with ultrasonic sonomicrometry. Left ventricular ejection fraction and rate of ventricular ejection (dV/dt) were measured with both ... Full text Link to item Cite