Scholars@Duke
Linda Gray Leithe

Linda Gray Leithe

Consulting Associate in the Department of Radiology
Radiology, Neuroradiology
linda.leithe@duke.edu
Box 3808 Med Ctr, Durham, NC 27710
1514A Hosp North, Durham, NC 27710

Selected Publications

CT Fluoroscopy-Guided Interlaminar Epidural Steroid Injections in the Cervical Spine: Rate of Nontarget Injection Into the Retrodural Space of Okada.

Journal Article AJR Am J Roentgenol · August 2018 OBJECTIVE: The purpose of this study was to assess the rate of inadvertent injection into the retrodural space of Okada during CT fluoroscopy-guided interlaminar epidural steroid injection in the cervical spine. MATERIALS AND METHODS: Images from cases of ... Full text Link to item Cite

Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions.

Journal Article Headache · July 2018 OBJECTIVE: To discuss common myths and misperceptions about spontaneous intracranial hypotension (SIH), focusing on common issues related to diagnosis and treatment, and to review the evidence that contradicts and clarifies these myths. BACKGROUND: Recogni ... Full text Link to item Cite

CSF Venous Fistulas in Spontaneous Intracranial Hypotension: Imaging Characteristics on Dynamic and CT Myelography.

Journal Article AJR Am J Roentgenol · December 2017 OBJECTIVE: The objective of this study is to describe the anatomic and imaging features of CSF venous fistulas, which are a recently reported cause of spontaneous intracranial hypotension (SIH). MATERIALS AND METHODS: We retrospectively reviewed the record ... Full text Link to item Cite

Incidence of Inadvertent Dural Puncture During CT Fluoroscopy-Guided Interlaminar Epidural Corticosteroid Injections in the Cervical Spine: An Analysis of 974 Cases.

Journal Article AJR Am J Roentgenol · September 2017 OBJECTIVE: The objective of this study is to determine the rate of inadvertent dural puncture during CT fluoroscopy-guided cervical interlaminar epidural corticosteroid injection. In addition, in a subanalysis, we aim to assess the rate of inadvertent dura ... Full text Link to item Cite

Update on the Diagnosis and Treatment of Spontaneous Intracranial Hypotension.

Journal Article Curr Pain Headache Rep · August 2017 PURPOSE OF REVIEW: The purpose of this study is to provide an update on recent developments in the understanding, diagnosis, and treatment of spontaneous intracranial hypotension (SIH). RECENT FINDINGS: SIH is an important cause of headaches caused by spin ... Full text Link to item Cite

Time-Dependent Changes in Dural Enhancement Associated With Spontaneous Intracranial Hypotension.

Journal Article AJR Am J Roentgenol · December 2016 OBJECTIVE: The objective of our study was to determine whether the presence of individual imaging signs of spontaneous intracranial hypotension (SIH) is correlated with increasing duration of headache symptoms. Of particular interest is the relationship of ... Full text Link to item Cite

How common is normal cerebrospinal fluid pressure in spontaneous intracranial hypotension?

Journal Article Cephalalgia · November 2016 Objectives To determine the proportion of patients with spontaneous intracranial hypotension (SIH) who had a cerebrospinal fluid (CSF) pressure >6 cm H2O and to investigate the clinical and imaging variables associated with CSF pressure ( PCSF) in this con ... Full text Link to item Cite

CT Fluoroscopy-Guided Blood Patching of Ventral CSF Leaks by Direct Needle Placement in the Ventral Epidural Space Using a Transforaminal Approach.

Journal Article AJNR Am J Neuroradiol · October 2016 BACKGROUND AND PURPOSE: Epidural blood patch treatment of spontaneous intracranial hypotension arising from ventral CSF leaks can be difficult secondary to challenges in achieving ventral spread of patching material. The purpose of this study was to determ ... Full text Link to item Cite

The "Hyperdense Paraspinal Vein" Sign: A Marker of CSF-Venous Fistula.

Journal Article AJNR Am J Neuroradiol · July 2016 CSF-venous fistula is a recently reported cause of spontaneous intracranial hypotension that may occur in the absence of myelographic evidence of CSF leak. Information about this entity is currently very limited, but it is of potential importance given the ... Full text Link to item Cite

Imaging Signs in Spontaneous Intracranial Hypotension: Prevalence and Relationship to CSF Pressure.

Journal Article AJNR Am J Neuroradiol · July 2016 BACKGROUND AND PURPOSE: Patients with spontaneous intracranial hypotension often exhibit low CSF pressure and changes on brain MR imaging and/or evidence of CSF leak on myelography. We investigated whether individual imaging signs of spontaneous intracrani ... Full text Link to item Cite

Atypical Presentations of Intracranial Hypotension: Comparison with Classic Spontaneous Intracranial Hypotension.

Journal Article AJNR Am J Neuroradiol · July 2016 BACKGROUND AND PURPOSE: Atypical clinical presentations of spontaneous intracranial hypotension include obtundation, memory deficits, dementia with frontotemporal features, parkinsonism, and ataxia. The purpose of this study was to compare clinical and ima ... Full text Link to item Cite

Myelographic Techniques for the Detection of Spinal CSF Leaks in Spontaneous Intracranial Hypotension.

Journal Article AJR Am J Roentgenol · January 2016 OBJECTIVE: Spinal leakage of CSF causes almost all cases of spontaneous intracranial hypotension. Leak detection and localization are important for both diagnosis and treatment. The myelographic appearance of the leaks may vary, however, depending on the c ... Full text Link to item Cite

Incidence of Inadvertent Intravascular Injection during CT Fluoroscopy-Guided Epidural Steroid Injections.

Journal Article AJNR Am J Neuroradiol · May 2015 BACKGROUND AND PURPOSE: Inadvertent intravascular injection during epidural steroid injection can result in complications and has been investigated previously with conventional fluoroscopy, but not CT fluoroscopy. The purpose of this study was to determine ... Full text Link to item Cite

Definitive diagnosis of cerebrospinal fluid leak into the pleural space using 111In-DTPA cisternography.

Journal Article Clin Nucl Med · March 2015 A 58-year-old woman with a calcified disk extrusion causing severe spinal stenosis underwent T8 to T9 diskectomy and spinal fusion. A postoperative pseudomeningocele was treated with lumbar drain and fibrin glue. Performed for persistent right pleural effu ... Full text Link to item Cite

Computed tomography-guided epidural patching of postoperative cerebrospinal fluid leaks.

Journal Article J Neurosurg Spine · November 2014 OBJECT: Cerebrospinal fluid leaks due to unrecognized durotomy during spinal surgery are often managed with a second surgery for dural closure. CT-guided percutaneous patching targeted to the dural defect offers an alternative to surgery since it can be pe ... Full text Link to item Cite

Rebound intracranial hypertension: a complication of epidural blood patching for intracranial hypotension.

Journal Article AJNR Am J Neuroradiol · June 2014 Rebound intracranial hypertension is a complication of epidural blood patching for treatment of intracranial hypotension characterized by increased intracranial pressure, resulting in potentially severe headache, nausea, and vomiting. Because the symptoms ... Full text Link to item Cite

Trends in spinal pain management injections in academic radiology departments.

Journal Article AJNR Am J Neuroradiol · January 2013 BACKGROUND AND PURPOSE: There is a paucity of information present in the current literature with regard to the role of SPMI performance in academic radiology centers. Our aim was to evaluate the current practice patterns for the performance of SPMIs in aca ... Full text Link to item Cite

Spinal meningeal diverticula in spontaneous intracranial hypotension: analysis of prevalence and myelographic appearance.

Journal Article AJNR Am J Neuroradiol · 2013 BACKGROUND AND PURPOSE: Spinal meningeal diverticula have been implicated in the pathogenesis of spontaneous intracranial hypotension and have been proposed as both diagnostic features of and therapeutic targets for the condition. We compared the prevalenc ... Full text Link to item Cite

Reply

Journal Article American Journal of Neuroradiology · December 1, 2012 Full text Cite

CT-guided lumbar nerve root injections: are we using the correct radiation dose settings?

Journal Article AJNR Am J Neuroradiol · November 2012 BACKGROUND AND PURPOSE: Selecting a lower tube current for CT fluoroscopic spine injections is a method of radiation dose reduction. Ideally tube current should be tailored to the patient's body habitus, but a greater influence on tube current may be the p ... Full text Link to item Cite

CT fluoroscopy-guided cervical interlaminar steroid injections: safety, technique, and radiation dose parameters.

Journal Article AJNR Am J Neuroradiol · August 2012 BACKGROUND AND PURPOSE: Cervical epidural steroid injections are approached with trepidation because of concerns over safety, including direct spinal cord injury. CT fluoroscopy is an alternative to conventional fluoroscopy that could potentially help redu ... Full text Link to item Cite

Radiographic progression of a Chiari I malformation after minor head trauma: Final increment of obstruction to create pathophysiology

Journal Article Journal of Surgical Radiology · December 1, 2011 Introduction The Chiari I malformation is a rare pathological condition that is characterized by a downward herniation of the cerebellar tonsils and brainstem through the foramen magnum. The transformation from an asymptomatic to symptomatic Chiari I malfo ... Cite

Radiation dose exposure for lumbar spine epidural steroid injections: a comparison of conventional fluoroscopy data and CT fluoroscopy techniques.

Journal Article AJR Am J Roentgenol · October 2011 OBJECTIVE: The purpose of this article is to compare the radiation dose of conventional fluoroscopy-guided lumbar epidural steroid injections (ESIs) and CT fluoroscopy (CTF)-guided lumbar ESI using both clinical data and anthropomorphic phantoms. MATERIALS ... Full text Link to item Cite

Resolution of syringohydromyelia with targeted CT-guided epidural blood patching.

Journal Article J Neurosurg · September 2011 In the scientific literature, syringohydromyelia has only rarely been reported in association with spontaneous intracranial hypotension. Management of the syringohydromyelia in these patients has heretofore involved relatively invasive surgical procedures. ... Full text Link to item Cite

CT-guided epidural blood patching of directly observed or potential leak sites for the targeted treatment of spontaneous intracranial hypotension.

Journal Article AJNR Am J Neuroradiol · May 2011 BACKGROUND AND PURPOSE: Optimal diagnosis and management of spontaneous intracranial hypotension remains uncertain. CT-guided blood patching has been described but has not been evaluated in larger case series. We sought to evaluate the efficacy of CT-guide ... Full text Link to item Cite

CT fluoroscopy-assisted cervical transforaminal steroid injection: tips, traps, and use of contrast material.

Journal Article AJR Am J Roentgenol · October 2010 OBJECTIVE: CT fluoroscopy-assisted cervical transforaminal steroid injection is an effective therapeutic option for cervical radiculopathy, yet it is approached with trepidation by some interventionalists. CT fluoroscopy is superior to conventional fluoros ... Full text Link to item Cite

Guidelines for the management of obstructive hydrocephalus from suprasellar-prepontine arachnoid cysts using endoscopic third ventriculocystocisternostomy.

Journal Article Surg Innov · September 2010 Intracranial endoscopy has emerged as an innovative surgical tool for various intracranial procedures, but its use remains limited to neurosurgeons trained in this minimally invasive technique. Complex, skull base arachnoid cysts represent one entity that ... Full text Link to item Cite

Kerma area product method for effective dose estimation during lumbar epidural steroid injection procedures: phantom study.

Journal Article AJR Am J Roentgenol · June 2009 OBJECTIVE: The purpose of this study was to derive from the kerma area product the dose conversion coefficient for estimating the effective dose for lumbar epidural steroid injection procedures. MATERIALS AND METHODS: A mobile fluoroscopy system was used f ... Full text Link to item Cite

ACR Appropriateness Criteria on low back pain.

Journal Article J Am Coll Radiol · June 2009 Acute low back pain with or without radiculopathy is one of the most common health problems in the United States, with high annual costs of evaluation and treatment, not including lost productivity. Multiple reports show that uncomplicated acute low back p ... Full text Link to item Cite

Predicting aspiration in patients with ischemic stroke: comparison of clinical signs and aerodynamic measures of voluntary cough.

Journal Article Chest · March 2009 BACKGROUND: Clinical signs often fail to identify stroke patients who are at increased risk of aspiration. We hypothesized that objective measure of voluntary cough would improve the accuracy of the clinical evaluation of swallow to predict those patients ... Full text Link to item Cite

Reliability and diagnostic accuracy of clinical special tests for myelopathy in patients seen for cervical dysfunction.

Journal Article J Orthop Sports Phys Ther · March 2009 STUDY DESIGN: Case control study. BACKGROUND: Myelopathy is a clinical diagnosis based largely on initial examination findings during a clinical screen, followed by imaging verification of cord injury or compression. At present, few studies have examined t ... Full text Link to item Cite

Analysis of the anatomic changes of the aging facial skeleton using computer-assisted tomography.

Journal Article Ophthalmic Plast Reconstr Surg · 2009 PURPOSE: The bony skeleton serves as the scaffolding for the soft tissues of the face; however, age-related changes of bony morphology are not well defined. This study sought to compare the anatomic relationships of the facial skeleton and soft tissue stru ... Full text Link to item Cite

Computed tomography-guided bilateral transdiscal superior hypogastric plexus neurolysis.

Journal Article Pain Med · April 2008 OBJECTIVE: This report describes a case of computed tomography (CT)-guided bilateral posteromedian transdiscal approach to the superior hypogastric plexus with neurolysis for treatment of intractable abdominal pain secondary to metastatic prostate cancer. ... Full text Link to item Cite

Cholesterol granuloma of the lateral ventricle. Case report.

Journal Article J Neurosurg · February 2008 Cholesterol granulomas (CGs) are benign lesions resulting from an inflammatory reaction to cholesterol and hemosiderin. These masses most often arise within the temporal bone or nasal sinuses; intracerebral CGs are extremely rare. In this report the author ... Full text Link to item Cite

Subacute combined degeneration due to copper deficiency.

Journal Article J Neuroimaging · October 2007 There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill-defined in dist ... Full text Link to item Cite

Neuroimaging for acute ischemic stroke

Journal Article Emergency Medicine · January 1, 2007 Cite

Jugular tubercle: Morphometric analysis and surgical significance.

Journal Article J Neurosurg · November 2006 OBJECT: Maximizing intradural exposure via the extreme lateral infrajugular transcondylar-transtubercular exposure (ELITE) approach depends on understanding the fundamental anatomy of the jugular tubercle (JT). Drilling the JT can maximize the extent of ex ... Full text Link to item Cite

Three-dimensional computed tomographic analysis of the relationship between the arcuate eminence and the superior semicircular canal.

Journal Article Neurosurgery · July 2006 OBJECTIVE: The location of the superior semicircular canal (SSC) is often determined intraoperatively based on its topographic association with the arcuate eminence (AE). This determination is not always possible because of the potential variability in the ... Full text Link to item Cite

Dural ectasia: a likely cause of inadequate spinal anaesthesia in two parturients with Marfan's syndrome.

Journal Article Br J Anaesth · April 2005 We report two cases of Caesarean section in patients with Marfan's syndrome where continuous subarachnoid anaesthesia failed to provide an adequate surgical block. This was possibly because of dural ectasia, which was confirmed by a computed tomography sca ... Full text Link to item Cite

Online medical teaching case database

Journal Article Proceedings of the IEEE Symposium on Computer-Based Medical Systems · September 29, 2004 Case-based teaching allows for the study of medicine through records of patient encounters. These cases, used for teaching purposes, are variably collected by clinicians as hard copies of patient files and radiology films. Currently, a single repository of ... Cite

Current practices in evaluating radiology residents, faculty, and programs: results of a survey of radiology residency program directors.

Journal Article Acad Radiol · July 2004 RATIONALE AND OBJECTIVES: We surveyed program directors to determine current radiology program practices in evaluating their residents, faculty, and program. MATERIALS AND METHODS: In January 2003, a 52-item Web-based survey was made available to program d ... Full text Link to item Cite

Sensitivity of spiral computed tomography scanning for detecting intraocular foreign bodies.

Journal Article Ophthalmology · December 2001 OBJECTIVE: The purpose of this study is to determine whether 3-mm computed tomography (CT) cuts are equivalent to 1-mm CT cuts for detecting small intraocular foreign bodies (IOFBs). DESIGN: Experimental instrument validation study. PARTICIPANTS: Seventy-t ... Full text Link to item Cite

Three-dimensional computed tomographic cranial base measurements for improvement of surgical approaches to the petrous carotid artery and apex regions.

Journal Article Neurosurgery · August 2001 OBJECTIVE: The bony and vascular anatomic features in the region of the petrous apex can vary significantly. These variations affect the operative view obtained via extended subtemporal or anterior transpetrosal approaches to cranial base lesions for indiv ... Full text Link to item Cite

Thoracic and lumbar spine trauma.

Journal Article Semin Ultrasound CT MR · April 2001 Complete thoracolumbar trauma evaluation incorporates radiographs, computed tomography, and magnetic resonance imaging. Primarily to localize the level of injury, diagnosis of thoracolumbar spine trauma begins with radiographs. Computed tomography with sag ... Full text Link to item Cite

Assessment of aspiration risk in stroke patients with quantification of voluntary cough.

Journal Article Neurology · February 27, 2001 BACKGROUND: Dysphagia and subsequent aspiration are serious complications of acute stroke that may be related to an impaired cough reflex. It was hypothesized that aspirating stroke patients would have impaired objective measures of voluntary cough as comp ... Full text Link to item Cite

Utility of three-dimensional computed tomographic angiography for assessment of relationships between the vertebrobasilar system and the cranial base.

Journal Article Neurosurgery · February 2001 OBJECTIVE: The optimal surgical exposure for basilar tip aneurysms is dictated by the relationship of the basilar bifurcation to the cranial base. This study was designed to evaluate three-dimensional computed tomographic angiography as a means of obtainin ... Full text Link to item Cite

Thoracic and lumbar spine trauma

Journal Article Neuroimaging Clinics of North America · January 1, 2001 Thoracic spine fractures are more difficult to diagnose and assess on conventional films. Lumbar fractures are easier to detect on radiographs. CT characterizes more fully the extent of all of the fractures, particularly those involving the posterior eleme ... Cite

Physician training requirements in sonography: how many cases are needed for competence?

Journal Article AJR Am J Roentgenol · May 2000 OBJECTIVE: Physician competence in the performance of sonographic studies was assessed after their involvement in predetermined increments of cases to determine whether the case volumes currently required by the American Institute of Ultrasound in Medicine ... Full text Link to item Cite

Parasitic lesion of the insula suggesting cerebral sparganosis: case report.

Journal Article Neuroradiology · March 2000 Cerebral sparganosis, a parasitic disease, rarely produces a chronic active inflammatory response in the brain. Clinically and radiographically the process may mimic a neoplasm. We report a 30-year-old man who underwent surgical exploration for a mass in t ... Full text Link to item Cite

Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.

Journal Article Neurology · December 10, 1999 We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon4 carriers had a higher mortality rate than non-epsilon4 carriers (38 v ... Full text Link to item Cite

Three-dimensional ct angiography for evaluating anatomic variations of the skull base in the region of the intrapetrous carotid

Journal Article Skull Base Surgery · December 1, 1999 Introduction: We evaluated 3-D CTA as a means of obtaining detailed anatomic information regarding differences in bony landmarks and spatial relationships in the region of the petrous carotid. Methods: Thirty patients underwent CT angiography with 1-mm sli ... Cite

Meningioma of the fourth ventricle.

Journal Article Clin Neuropathol · 1999 Meningiomas are primary meningeal based tumors of the central nervous system that rarely are located strictly within the fourth ventricle. We report a 72-year-old man operated upon for such a tumor. The pre-operative magnetic resonance images revealed a we ... Link to item Cite

One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.

Journal Article J Inherit Metab Dis · December 1998 Non-ketotic hyperglycinaemia (NKH) is a rare, severe brain disease caused by deficient glycine cleavage enzyme complex activity resulting in elevated glycine concentrations. Recent experience suggests that factors in addition to glycine kinetics are involv ... Full text Link to item Cite

Dementia associated with hyperphosphatemic tumoral calcinosis.

Journal Article Clin Neurol Neurosurg · June 1998 Hyperphosphatemic tumoral calcinosis (HTC) is a rare inherited metabolic disorder manifested by pararticular calcification and hyperphosphatemia, caused by an elevated renal phosphate reabsorption threshold and elevated serum 1,25-dihydroxyvitamin D levels ... Full text Link to item Cite

Overview of diffusion imaging.

Journal Article Magn Reson Imaging Clin N Am · February 1998 Diffusion is a major advance in the continuing evolution of MR imaging. It provides contrasts and characterization between tissues at a cellular level that may imply differences in function as well as framework. With the development of echo-planar imaging ... Link to item Cite

Diagnosis of intracranial vasculitis: a multi-disciplinary approach.

Journal Article J Neuropathol Exp Neurol · January 1998 Intracranial vasculitis, or primary angiitis of the central nervous system (PACNS), is an uncommon, often fatal disorder that frequently responds to aggressive immunosuppressive therapy. Magnetic resonance imaging (MRI), cerebral angiography, and brain bio ... Full text Link to item Cite

Solitary fibrous tumor of the meninges occurring after irradiation of a mixed germ cell tumor of the pineal gland.

Journal Article Clin Neuropathol · 1998 Twenty-nine months after surgery, irradiation, and systemic chemotherapy for a pineal mixed germ cell tumor, an 11-year-old Caucasian male developed a 3 cm dural based nodule in the occipital lobe that proved to be a solitary fibrous tumor by immunohistoch ... Link to item Cite

High-dose gadolinium-enhanced MRI for diagnosis of meningeal metastases.

Journal Article Neuroradiology · January 1998 We compared high-dose (0.3 mmol/kg) and standard-dose (0.1 mmol/kg) gadolinium-enhanced MRI for diagnosis of meningeal metastases in 12 patients with suspected meningeal metastases. They were imaged with both standard-dose and high-dose gadolinium. All pat ... Full text Link to item Cite

Transcranial doppler sonography to monitor cerebral vasculitis.

Journal Article J Rheumatol · March 1996 We describe a patient with cerebral vasculitis treated with prednisone and cyclophosphamide and followed by serial transcranial Doppler sonography and arteriography. Proximal cerebral angiographic abnormalities correlated with transcranial Doppler abnormal ... Link to item Cite

Neuro-Behcet's disease in Japan - Reply

Journal Article NEUROLOGY · 1996 Full text Cite

Neuro-Behçet's disease: factors hampering proper diagnosis.

Journal Article Neurology · September 1995 We reviewed the clinical course of nine patients with neuro-Behçet's disease to assess difficulties in making this diagnosis. Factors delaying proper diagnosis included lack of accurate history and physical examination, lack of recognition of an underlying ... Full text Link to item Cite

Stroke due to recurrent ipsilateral carotid artery dissection in a young adult.

Journal Article Stroke · March 1995 BACKGROUND: Extracranial carotid artery dissection is a well-recognized cause of ischemic stroke. Recurrent carotid artery dissections are infrequent. Recurrent ipsilateral dissection has only rarely been documented and has not been pathologically verified ... Full text Link to item Cite

Brain computerized tomography after hyperbaric oxygen therapy for carbon monoxide poisoning.

Journal Article Undersea Hyperb Med · March 1995 The role of brain computerized tomography (CT) imaging in predicting clinical outcome was investigated in patients receiving hyperbaric oxygen therapy for serious carbon monoxide (CO) poisoning. From a series of 48 consecutive patients suffering loss of co ... Link to item Cite

Preoperative transarterial embolization of spinal column neoplasms.

Journal Article J Vasc Interv Radiol · 1995 PURPOSE: To determine the safety and value of vertebral column embolization before surgical resection of vascular neoplastic disease. PATIENTS AND METHODS: Thirty preoperative embolization procedures were performed in 20 patients with vascular neoplasms of ... Full text Link to item Cite

Vascular malformations presenting as spinal cord neoplasms: case report.

Journal Article Neurosurgery · January 1995 Three cases of adult patients with subacute courses of progressive caudal spinal cord disease are presented. Computed tomography, magnetic resonance imaging, and myelographic studies were interpreted preoperatively as representing a spinal cord neoplasm in ... Full text Link to item Cite

The CERAD experience, Part VIII: Neuroimaging-neuropathology correlates of temporal lobe changes in Alzheimer's disease.

Journal Article Neurology · January 1995 We compared premortem neuroimaging findings with neuropathologic evidence of temporal lobe atrophy in 20 patients with Alzheimer's disease (AD) confirmed by autopsy. There were significant correlations between temporal horn enlargement observed by neuroima ... Full text Link to item Cite

Magnetic resonance imaging of medical diseases of the spine

Journal Article Seminars in Spine Surgery · January 1, 1995 In conclusion, MRI has been shown to be the most sensitive test for the evaluation of bone marrow. It is lacking in its ability to screen the entire skeleton, as can be done with BS. MRI, however, is more sensitive for identifying osteoclastic processes of ... Cite

Cerebral imaging of decompression injury patients with 18-F-2-fluoro-2-deoxyglucose positron emission tomography.

Journal Article Undersea Hyperb Med · June 1994 The objective assessment of the extent of cerebral insult and the effects of therapy in decompression injury patients has proven to be difficult by most imaging modalities. In this pilot study we evaluated the ability of 18-F-2-fluoro-2-deoxyglucose (FDG) ... Link to item Cite

Neuronal migration disorders: positron emission tomography correlations.

Journal Article Ann Neurol · March 1994 We analyzed the interictal [18F]fluoro-2-deoxy-D-glucose positron emission tomography (PET) findings of 17 epileptic patients with neuronal migration disorders (NMDs). Fifteen patients had abnormal PET findings, i.e., focal hypometabolism in 9 patients and ... Full text Link to item Cite

Mesenrhombencephalitis: MR findings in nine patients.

Journal Article AJR Am J Roentgenol · May 1993 OBJECTIVE: Mesenrhombencephalitis is a serious form of brainstem inflammation predominantly involving the deep and vital portions of the brain, that is, the mesencephalon (midbrain) and rhombencephalon (pons, medulla). Mesenrhombencephalitis is difficult t ... Full text Link to item Cite

FDG-PET in differentiating lymphoma from nonmalignant central nervous system lesions in patients with AIDS.

Journal Article J Nucl Med · April 1993 Structural imaging studies such as CT or MRI are not able to accurately differentiate infectious from malignant cerebral lesions in patients with AIDS. We studied 11 individuals with AIDS and central nervous system (CNS) lesions with 18F-fluoro-2-deoxygluc ... Link to item Cite

False-positive MRI detection of recurrent or metastatic pediatric infratentorial tumors.

Journal Article Med Pediatr Oncol · 1993 Gadolinium-DTPA enhanced MRI is the modality of choice when imaging central nervous system infratentorial tumors in the pediatric population. The detection of a new enhancing lesion following initiation of therapy is typically considered pathognomonic for ... Full text Link to item Cite

Acute spinal ligament disruption: MR imaging with anatomic correlation.

Journal Article J Magn Reson Imaging · 1993 Disruption of spinal ligaments can lead to instability that jeopardizes the spinal cord and nerve roots. Magnetic resonance (MR) imaging can directly image spinal ligaments; however, the sensitivity with which this modality demonstrates ligament injury has ... Full text Link to item Cite

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part III. Reliability of a standardized MRI evaluation of Alzheimer's disease.

Journal Article Neurology · September 1992 The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) has developed procedures for standardized imaging and reporting of magnetic resonance (MR) findings in Alzheimer's disease (AD) for use by neuroradiologists in multiple medical centers ... Full text Link to item Cite

Stroke with negative brain magnetic resonance imaging.

Journal Article Stroke · May 1992 BACKGROUND AND PURPOSE: Magnetic resonance imaging (MRI) of the brain is replacing computed tomography in the diagnostic evaluation of acute ischemic strokes. Past studies have suggested that MRI may not visualize all acute strokes, but few clinical detail ... Full text Link to item Cite

Phase III clinical evaluation of gadoteridol injection: experience in pediatric neuro-oncologic MR imaging.

Journal Article Pediatr Radiol · 1992 Twenty-two pediatric patients with known CNS neoplasms underwent magnetic resonance (MR) imaging before and after intravenous injection of 0.1 mmol/kg gadoteridol injection as part of a Phase IIIB open label multicenter clinical trial. Intravenous administ ... Full text Link to item Cite

Aspiration after stroke: lesion analysis by brain MRI.

Journal Article Dysphagia · 1992 Aspiration is a common problem following stroke, resulting in feeding difficulties and aspiration pneumonia. Despite past studies using clinical assessments and computed tomographic (CT) scans of the head, the correlation of stroke location with aspiration ... Full text Link to item Cite

The role of torsion in cervical spine trauma.

Journal Article Spine (Phila Pa 1976) · August 1991 A dynamic servocontrolled torsion machine has been used to characterize cervical injury due to pure rotation of the head. Resultant force moment, torque, and applied rotation have been measured. Torque applied to the base of the skull resulted in injury to ... Full text Link to item Cite

Responses of the human cervical spine to torsion

Journal Article SAE Technical Papers · January 1, 1989 The passive torsional responses of the human cervical spine were investigated using unembalmed cervical spines in a dynamic test environment. Kinematic constraints were designed to simulate in vivo conditions. A physiologic axis of twist was determined bas ... Full text Cite

MR imaging of thoracic extradural arachnoid cysts.

Journal Article J Comput Assist Tomogr · 1988 Two extradural arachnoid cysts of the thoracic spine were studied with magnetic resonance imaging, myelography, and CT. Magnetic resonance imaging correctly characterized the extradural location of the cysts as well as the cyst contents as CSF, thus establ ... Full text Link to item Cite

Combined bending and axial loading responses of the human cervical spine

Journal Article SAE Technical Papers · January 1, 1988 The lateral, anterior and posterior passive bending responses of the human cervical spine were investigated using unembalmed cervical spinal elements obtained from cadavers. Bending stiffness was measured in six modes ranging from tension-extension through ... Full text Cite