Scholars@Duke
Lynne Michelle Hurwitz Koweek

Lynne Michelle Hurwitz Koweek

Professor of Radiology
Radiology, Cardiothoracic Imaging
lynne.koweek@duke.edu
Box 3808 Med Ctr, Durham, NC 27710
Hosp North Box 3808, Department of Radiology, Durham, NC 27710

Selected Publications

Standardized medical terminology for cardiac computed tomography 2023 update: An Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT), American Association of Physicists in Medicine (AAPM), American College of Radiology (ACR), North American Society for Cardiovascular Imaging (NASCI) and Radiological Society of North America (RSNA) with endorsement by the Asian Society of Cardiovascular Imaging (ASCI), the European Association of Cardiovascular Imaging (EACI), and the European Society of Cardiovascular Radiology (ESCR).

Journal Article J Cardiovasc Comput Tomogr · 2023 Since the emergence of cardiac computed tomography (Cardiac CT) at the turn of the 21st century, there has been an exponential growth in research and clinical development of the technique, with contributions from investigators and clinicians from varied ba ... Full text Link to item Cite

CAD-RADS™ 2.0 - 2022 Coronary Artery Disease-Reporting and Data System: An Expert Consensus Document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Cardiology (ACC), the American College of Radiology (ACR), and the North America Society of Cardiovascular Imaging (NASCI).

Journal Article J Cardiovasc Comput Tomogr · 2022 Coronary Artery Disease Reporting and Data System (CAD-RADS) was created to standardize reporting system for patients undergoing coronary CT angiography (CCTA) and to guide possible next steps in patient management. The goal of this updated 2022 CAD-RADS 2 ... Full text Link to item Cite

Coronary artery calcium: A technical argument for a new scoring method.

Journal Article J Cardiovasc Comput Tomogr · 2019 Coronary artery calcium (CAC) is a strong predictor for future cardiovascular events. Traditionally CAC has been quantified using the Agatston score, which was developed in the late 1980s for electron beam tomography (EBT). While EBT has been completely re ... Full text Link to item Cite

ACR Appropriateness Criteria® Chronic Chest Pain-Noncardiac Etiology Unlikely-Low to Intermediate Probability of Coronary Artery Disease.

Journal Article J Am Coll Radiol · November 2018 Chronic chest pain (CCP) of a cardiac etiology is a common clinical problem. The diagnosis and classification of the case of chest pain has rapidly evolved providing the clinician with multiple cardiac imaging strategies. Though scintigraphy and rest echoc ... Full text Link to item Cite

ACR Appropriateness Criteria® Suspected New-Onset and Known Nonacute Heart Failure.

Journal Article J Am Coll Radiol · November 2018 While there is no single diagnostic test for heart failure (HF), imaging plays a supportive role beginning with confirmation of HF, especially by detecting ventricular dysfunction (Variant 1). Ejection fraction (EF) is important in HF classification, and i ... Full text Link to item Cite

Metal Artifact-Free and Dose-Efficient Computed Tomography Imaging of a Cardiac Prosthetic Valve Using Spectral Shaping of the X-ray Beam: A Case Report.

Journal Article J Comput Assist Tomogr · 2018 Bioprosthetic valve (BPV) thrombosis can be challenging to diagnose with cardiac computed tomography owing to metal artifacts of the BPV. In this case report, an optimized metal artifact reduction protocol using a third-generation dual-source multidetector ... Full text Link to item Cite

Whole-Body High-Pitch CT Angiography: Strategies to Reduce Radiation Dose and Contrast Volume.

Journal Article AJR Am J Roentgenol · December 2017 OBJECTIVE: The purpose of this study was to assess the noninferiority of dual-source high-pitch CT angiography (CTA) performed with high-concentration (iopamidol 370) low-volume (60 mL) iodinated contrast material at low voltage (100 kVp) in comparison wit ... Full text Link to item Cite

ACR Appropriateness Criteria® Imaging for Transcatheter Aortic Valve Replacement.

Journal Article J Am Coll Radiol · November 2017 Aortic stenosis is a common valvular condition with increasing prevalence in aging populations. When severe and symptomatic, the downstream prognosis is poor without surgical or transcatheter aortic valve replacement. Transcatheter aortic valve replacement ... Full text Link to item Cite

MRI of the Central Lymphatic System: Indications, Imaging Technique, and Pre-Procedural Planning.

Journal Article Top Magn Reson Imaging · August 2017 Magnetic resonance imaging is increasingly being used to evaluate the lymphatic system. Advances in magnetic resonance (MR) software and hardware allow improved visualization of lymph nodes and lymphatic vessels. We describe how MR lymphangiography can be ... Full text Link to item Cite

MR Venography of the Central Veins of the Thorax.

Journal Article Topics in magnetic resonance imaging : TMRI · August 2017 While imaging of the central venous system has traditionally been performed with conventional venography, MR venography (MRV) has emerged as an important modality as techniques and validation studies have evolved over time. While magnetic resonance angiogr ... Full text Cite

Dual-Source Single-Energy Multidetector CT Used to Obtain Multiple Radiation Exposure Levels within the Same Patient: Phantom Development and Clinical Validation.

Journal Article Radiology · May 2017 Purpose To develop, in a phantom environment, a method to obtain multidetector computed tomographic (CT) data sets at multiple radiation exposure levels within the same patient and to validate its use for potential dose reduction by using different image r ... Full text Link to item Cite

ACR Appropriateness Criteria® Dyspnea-Suspected Cardiac Origin.

Journal Article J Am Coll Radiol · May 2017 This article discusses imaging guidelines for five dyspnea variants: (1) dyspnea due to heart failure, ischemia not excluded; (2) dyspnea due to suspected nonischemic heart failure, ischemia excluded; (3) dyspnea due to suspected valvular heart disease, is ... Full text Link to item Cite

Use of Preprocedural MDCT for Cardiac Implantable Electric Device Lead Extraction: Frequency of Findings That Change Management.

Journal Article AJR Am J Roentgenol · April 2017 OBJECTIVE: Five percent of cardiac implantable electric devices (CIEDs) are removed each year. Percutaneous extraction is preferred but can be complicated if the leads adhere to the vasculature or perforate. The goal of this study is to assess the frequenc ... Full text Link to item Cite

Imaging Surveillance After Proximal Aortic Operations: Is it Necessary?

Journal Article Ann Thorac Surg · March 2017 BACKGROUND: Current guidelines for imaging surveillance after proximal aortic repair are not evidence based. This study sought to characterize the incidence and causes of reintervention after proximal aortic operations to provide data to guide the frequenc ... Full text Link to item Cite

Resolution of severe hemolysis and paravalvular aortic regurgitation employing an Amplatzer Vascular Plug 4: the importance of detailed pre-procedural planning using CT angiography.

Journal Article Cardiovasc Interv Ther · January 2017 A 76-year-old woman presented with progressive heart failure and transfusion-dependent hemolytic anemia due to severe paravalvular aortic regurgitation 4 years after bioprosthetic aortic valve replacement. She was deemed not to be a candidate for redo card ... Full text Link to item Cite

Non-dysbaric arterial gas embolism associated with chronic necrotizing pneumonia, bullae and coughing: a case report.

Journal Article Undersea Hyperb Med · 2017 Arterial gas embolism (AGE) can be clinically devastating, and is most often associated with exposure to changes in ambient pressure, medical procedure or congenital malformation. Here we report a case of AGE in a 78-year-old male without these traditional ... Full text Link to item Cite

Patient-specific quantification of image quality: An automated method for measuring spatial resolution in clinical CT images.

Journal Article Med Phys · October 2016 PURPOSE: To develop and validate an automated technique for evaluating the spatial resolution characteristics of clinical computed tomography (CT) images. METHODS: Twenty one chest and abdominopelvic clinical CT datasets were examined in this study. An alg ... Full text Link to item Cite

Regional Mapping of Aortic Wall Stress by Using Deformable, Motion-coherent Modeling based on Electrocardiography-gated Multidetector CT Angiography: Feasibility Study.

Journal Article Radiology · July 2016 Purpose To investigate the feasibility of deformable, motion-coherent modeling based on electrocardiography-gated multidetector computed tomographic (CT) angiography of the thoracic aorta and to evaluate whether quantifiable information on aortic wall stre ... Full text Link to item Cite

Application of a Novel CT-Based Iliac Artery Calcification Scoring System for Predicting Renal Transplant Outcomes.

Journal Article AJR Am J Roentgenol · February 2016 OBJECTIVE: The objective of our study was to assess whether the degree and distribution of iliac artery calcifications as determined by a CT-based calcium scoring system correlates with outcomes after renal transplant. MATERIALS AND METHODS: A retrospectiv ... Full text Link to item Cite

High-Pitch Dual-Source MDCT for Imaging of the Thoracoabdominal Aorta: Relationships Among Radiation Dose, Noise, Pitch, and Body Size in a Phantom Experiment and Clinical Study.

Journal Article AJR Am J Roentgenol · October 2015 OBJECTIVE: The purpose of this study was to investigate, both in a phantom experiment and a within-patient clinical study the relationships among radiation dose, image noise, pitch, and body size in MDCT angiography of the thoracoabdominal aorta, with the ... Full text Link to item Cite

Localization of pacing and defibrillator leads using standard x-ray views is frequently inaccurate and is not reproducible.

Journal Article J Interv Card Electrophysiol · June 2015 PURPOSE: While the accuracy of roentography for evaluation of lead tip position compared with three-dimensional imaging techniques has been well described, there remains considerable variability in the interpretation of the reproducibility of standard x-ra ... Full text Link to item Cite

Comparison of aortic annulus size by transesophageal echocardiography and computed tomography angiography with direct surgical measurement.

Journal Article Am J Cardiol · June 1, 2015 This study sought to compare the accuracy of 2-dimensional transesophageal echocardiography (TEE) and computed tomography angiography (CTA) for noninvasive aortic annular sizing as required for transcatheter aortic valve implantation (TAVI). Direct intraop ... Full text Link to item Cite

Characterizing search, recognition, and decision in the detection of lung nodules on CT scans: elucidation with eye tracking.

Journal Article Radiology · January 2015 PURPOSE: To determine the effectiveness of radiologists' search, recognition, and acceptance of lung nodules on computed tomographic (CT) images by using eye tracking. MATERIALS AND METHODS: This study was performed with a protocol approved by the institut ... Full text Link to item Cite

Effects of model-based iterative reconstruction on image quality for low-dose computed tomographic angiography of the thoracic aorta in a Swine model.

Journal Article J Comput Assist Tomogr · 2015 PURPOSE: The aim of the study was to assess the image quality of multi-detector-row computed tomography (CT) angiographic images of the thoracic aorta reconstructed with filtered back projection (FBP), adaptive statistical iterative reconstruction, and mod ... Full text Link to item Cite

Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement.

Journal Article J Comput Assist Tomogr · 2015 PURPOSE: This study aimed to assess vascular contrast opacification and homogeneity using single-bolus contrast administration with hybrid thoracic and abdominopelvic computed tomographic angiography in patients with severe aortic valve stenosis. MATERIALS ... Full text Link to item Cite

Preprocedural ECG-gated computed tomography for prevention of complications during lead extraction.

Journal Article Pacing Clin Electrophysiol · October 2014 BACKGROUND: Preprocedural multidetector computed tomography (MDCT) may identify patients at risk for mechanical complications during lead extraction. METHODS: To describe the use and feasibility of computed tomography scanning for preprocedural planning of ... Full text Link to item Cite

Assessment of vascular contrast and wall motion of the aortic root and ascending aorta on MDCT angiography: dual-source high-pitch vs non-gated single-source acquisition schemes.

Journal Article Eur Radiol · May 2014 OBJECTIVES: This retrospective study assessed whether dual-source high-pitch computed tomographic angiography (CTA) offered advantages over single-source standard-pitch techniques in the evaluation of the ascending aorta. METHODS: Twenty patients who recei ... Full text Link to item Cite

Frailty and risk in proximal aortic surgery.

Journal Article J Thorac Cardiovasc Surg · January 2014 OBJECTIVES: Although frailty has recently been examined in various populations as a predictor of morbidity and mortality, its effect on thoracic aortic surgery outcomes has not been studied. The objective of the present study was to evaluate the role of fr ... Full text Link to item Cite

Transcatheter aortic valve replacement: an update.

Journal Article Curr Cardiol Rep · June 2013 Aortic stenosis affects many people worldwide with a significant impact on morbidity and mortality with uncorrected, symptomatic aortic valve stenosis carrying mortality of 50% at one year. Degenerative calcific pathology, the most common cause of aortic s ... Full text Link to item Cite

Preliminary evaluation of biplane correlation (BCI) stereographic imaging for lung nodule detection.

Journal Article J Digit Imaging · February 2013 A biplane correlation (BCI) imaging system obtains images that can be viewed in stereo, thereby minimizing overlapping structures. This study investigated whether using stereoscopic visualization provides superior lung nodule detection compared to standard ... Full text Link to item Cite

SU‐D‐103‐06: Bismuth Shield Usage in MDCT Thoracic Scans: Organ Dose Vs. Image Quality

Conference Medical Physics · January 1, 2013 Purpose: To study Bismuth (Bi) shielding for the breast, organ dose and image quality were compared under the following conditions: (1) tube current modulation (TCM), (2) TCM with a Bi shield placed after topogram, and (3) manually reduced tube current (RT ... Full text Cite

Ascending thoracic aorta: postoperative imaging evaluation.

Journal Article Radiographics · 2013 Advances in computed tomography (CT) scanners and electrocardiographic gating techniques have resulted in superior image quality of the ascending aorta and increased the use of CT angiography for evaluating the postoperative ascending aorta. Several abnorm ... Full text Link to item Cite

The effects of ambient lighting in chest radiology reading rooms.

Journal Article J Digit Imaging · August 2012 Under typical dark chest radiography reading room conditions, a radiologist's pupils contract and dilate as their visual focus intermittently shifts between the high luminance monitor and the darker background wall, resulting in increased visual fatigue an ... Full text Link to item Cite

Radiation dose estimations to the thorax using organ-based dose modulation.

Journal Article AJR Am J Roentgenol · July 2012 OBJECTIVE: The purpose of this study was to assess the radiation dose distribution and image quality for organ-based dose modulation during adult thoracic MDCT. MATERIALS AND METHODS: Organ doses were measured using an anthropomorphic adult female phantom ... Full text Link to item Cite

Organ-based dose current modulation and thyroid shields: techniques of radiation dose reduction for neck CT.

Journal Article AJR Am J Roentgenol · May 2012 OBJECTIVE: The purpose of this study was to assess the difference in absorbed organ dose and image quality for MDCT neck protocols using automatic tube current modulation alone compared with organ-based dose modulation and in-plane thyroid bismuth shieldin ... Full text Link to item Cite

Variation in tube voltage for adult neck MDCT: effect on radiation dose and image quality.

Journal Article AJR Am J Roentgenol · March 2012 OBJECTIVE: The purpose of this study was to assess the effect of peak kilovoltage on radiation dose and image quality in adult neck MDCT. MATERIALS AND METHODS: An anthropomorphic phantom with metal oxide semiconductor field effect transistor detectors was ... Full text Link to item Cite

American Thoracic Society documents: an official American Thoracic Society/Society of Thoracic Radiology Clinical Practice Guideline--Evaluation of Suspected Pulmonary Embolism in Pregnancy.

Journal Article Radiology · February 2012 BACKGROUND: Pulmonary embolism (PE) is a leading cause of maternal mortality in the developed world. Along with appropriate prophylaxis and therapy, prevention of death from PE in pregnancy requires a high index of clinical suspicion followed by a timely a ... Full text Link to item Cite

Gray-scale inversion radiographic display for the detection of pulmonary nodules on chest radiographs.

Journal Article Clin Imaging · 2012 The purpose of this study was to investigate gray-scale inversion in nodule detection on chest radiography. Simulated nodules were superimposed randomly onto normal chest radiographs. Six radiologists interpreted 144 chest radiographs during three reading ... Full text Link to item Cite

An official American Thoracic Society/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy.

Journal Article Am J Respir Crit Care Med · November 15, 2011 BACKGROUND: Pulmonary embolism (PE) is a leading cause of maternal mortality in the developed world. Along with appropriate prophylaxis and therapy, prevention of death from PE in pregnancy requires a high index of clinical suspicion followed by a timely a ... Full text Link to item Cite

Correlation of cross-sectional diameter with image quality and radiation exposure in MDCT examinations of the neck.

Journal Article AJR Am J Roentgenol · November 2011 OBJECTIVE: The purpose of this study was to identify an optimal cross-sectional neck diameter that correlates with image quality and radiation exposure in MDCT examinations of the neck performed with automatic tube current modulation. MATERIALS AND METHODS ... Full text Link to item Cite

Radiation dose exposure for lumbar spine epidural steroid injections: a comparison of conventional fluoroscopy data and CT fluoroscopy techniques.

Journal Article AJR Am J Roentgenol · October 2011 OBJECTIVE: The purpose of this article is to compare the radiation dose of conventional fluoroscopy-guided lumbar epidural steroid injections (ESIs) and CT fluoroscopy (CTF)-guided lumbar ESI using both clinical data and anthropomorphic phantoms. MATERIALS ... Full text Link to item Cite

Effects of iopamidol-370 versus iodixanol-320 on coronary contrast, branch depiction, and heart rate variability in dual-source coronary MDCT angiography.

Journal Article AJR Am J Roentgenol · September 2011 OBJECTIVE: The purpose of this article is to assess whether iopamidol-370 provides superior vascular contrast of the coronaries and depiction of anatomic detail without affecting heart rate and beat-to-beat variability during coronary dual-source MDCT comp ... Full text Link to item Cite

SU‐E‐I‐51: Estimating Effective Dose from Phantom Dose Measurements in Atrial Fibrillation Ablation Procedures

Conference Medical Physics · January 1, 2011 Purpose: The purpose of this study was three‐fold: (a) to estimate organ doses and effective dose (ED) for atrial fibrillation (AF) ablation from clinical fluoro times, (b) to estimate carcinogenic risks for organ doses, and (c) to derive the dose conversi ... Full text Cite

Utility of FDG PET/CT in inflammatory cardiovascular disease.

Journal Article Radiographics · 2011 Inflammatory disorders of the cardiovascular system can affect the myocardium, pericardium, or vessel walls. Patients with myocardial and pericardial disease may present with chest pain, palpitations, and shortness of breath, symptoms resembling myocardial ... Full text Link to item Cite

Relation of size of secondary ventricles to exercise performance in children after fontan operation.

Journal Article Am J Cardiol · December 1, 2010 The effects of the nondominant or secondary ventricle on the Fontan circulation are not known. The present study used cardiac magnetic resonance imaging to investigate the relations between secondary ventricular size and global cardiac performance. The Fon ... Full text Link to item Cite

Dual energy versus single energy MDCT: measurement of radiation dose using adult abdominal imaging protocols.

Journal Article Acad Radiol · November 2009 RATIONALE AND OBJECTIVES: The aim of this study was to measure the radiation dose of dual-energy and single-energy multidetector computed tomographic (CT) imaging using adult liver, renal, and aortic imaging protocols. MATERIALS AND METHODS: Dual-energy CT ... Full text Link to item Cite

Comparison of echocardiographic and cardiac magnetic resonance imaging measurements of functional single ventricular volumes, mass, and ejection fraction (from the Pediatric Heart Network Fontan Cross-Sectional Study).

Journal Article Am J Cardiol · August 1, 2009 Assessment of the size and function of a functional single ventricle (FSV) is a key element in the management of patients after the Fontan procedure. Measurement variability of ventricular mass, volume, and ejection fraction (EF) among observers by echocar ... Full text Link to item Cite

Functional state following the Fontan procedure.

Journal Article Cardiol Young · August 2009 BACKGROUND: Despite improvements in outcomes after completion of the Fontan circulation, long-term functional state varies. We sought to identify pre- and postoperative characteristics associated with overall function. METHODS AND RESULTS: We analyzed data ... Full text Link to item Cite

MDCT angiography of thoracic aorta endovascular stent-grafts: pearls and pitfalls.

Journal Article AJR Am J Roentgenol · February 2009 OBJECTIVE: The objective of our study was to review expected findings and complications after thoracic endovascular aortic repair on CT angiography (CTA). CONCLUSION: Luminal and extraluminal changes to the thoracic aorta occur after endovascular stent-gra ... Full text Link to item Cite

MDCT angiography after open thoracic aortic surgery: pearls and pitfalls.

Journal Article AJR Am J Roentgenol · January 2009 OBJECTIVE: The purpose of this article is to review open thoracic aortic surgical techniques and to describe the range of postoperative findings on CT angiography (CTA). CONCLUSION: An understanding of surgical thoracic aortic procedures will allow appropr ... Full text Link to item Cite

Optimization of tube current in coronary multidetector computed tomography angiography: assessment of a standardized method to individualize current selection based on body habitus.

Journal Article J Comput Assist Tomogr · 2009 UNLABELLED: This study sought to extract information on individual patient habitus from scout imaging and to correlate radiograph tube current settings with enhancement of the coronaries as a function of patient profiles for coronary multidetector computed ... Full text Link to item Cite

Radiation dose savings for adult pulmonary embolus 64-MDCT using bismuth breast shields, lower peak kilovoltage, and automatic tube current modulation.

Journal Article AJR Am J Roentgenol · January 2009 OBJECTIVE: The purpose of this study was to assess whether radiation dose savings using a lower peak kilovoltage (kVp) setting, bismuth breast shields, and automatic tube current modulation could be achieved while preserving the image quality of MDCT scans ... Full text Link to item Cite

Evaluation of combined cardiac positron emission tomography and coronary computed tomography angiography for the detection of coronary artery disease.

Journal Article Nucl Med Commun · July 2008 BACKGROUND: Coronary artery disease is a leading cause of morbidity and mortality. Multiple imaging modalities are used to screen for significant coronary artery disease. We report the concordance between coronary computed tomography angiography (CTA) and ... Full text Link to item Cite

Response

Journal Article Radiology · July 1, 2008 Full text Cite

Early first-trimester fetal radiation dose estimation in 16-MDCT without and with automated tube current modulation.

Journal Article AJR Am J Roentgenol · April 2008 OBJECTIVE: The objective of our study was to correlate the estimated fetal absorbed radiation dose derived by directly measured uterine doses in the early first trimester and the volume CT dose index (CTDI(vol)) for 16-MDCT of the maternal chest, abdomen, ... Full text Link to item Cite

New classes of anticoagulation and antiplatelet agents: preprocedure management and safety guidelines for imaging-guided intervention.

Journal Article J Comput Assist Tomogr · 2008 OBJECTIVE: New medications are available for prophylaxis of deep venous thrombosis, the treatment of venous thromboembolism, and also to reduce the risk of acute coronary syndrome and stroke. The purpose of this review is to provide the radiologist a pract ... Full text Link to item Cite

Radiation dose from contemporary cardiothoracic multidetector CT protocols with an anthropomorphic female phantom: implications for cancer induction.

Journal Article Radiology · December 2007 PURPOSE: To measure prospectively and directly both organ dose and effective dose (ED) for adult cardiac and pulmonary computed tomographic (CT) angiography by using current clinical protocols for 64-detector CT in an anthropomorphic female phantom and to ... Full text Link to item Cite

Right heart dilatation in adults: congenital causes.

Journal Article AJR Am J Roentgenol · September 2007 OBJECTIVE: The purpose of this article is to illustrate the common congenital cardiac lesions that are characterized by right-sided heart enlargement that may be seen on routine thoracic or cardiac imaging. CONCLUSION: A systematic approach to the evaluati ... Full text Link to item Cite

Pediatric cardiac-gated CT angiography: assessment of radiation dose.

Journal Article AJR Am J Roentgenol · July 2007 OBJECTIVE: The purpose of our study was to determine a dose range for cardiac-gated CT angiography (CTA) in children. MATERIALS AND METHODS: ECG-gated cardiac CTA simulating scanning of the heart was performed on an anthropomorphic phantom of a 5-year-old ... Full text Link to item Cite

Noninvasive imaging for coronary artery disease: a technology assessment for the Medicare Coverage Advisory Commission.

Journal Article Am Heart J · February 2007 This report describes a review of the available scientific evidence through 2005 on direct noninvasive imaging tests (NITs) for coronary artery disease. In particular, the report addresses 6 key questions provided by the Agency for Healthcare Research and ... Full text Link to item Cite

Rapid detection of myocardial infarction by subsecond, free-breathing delayed contrast-enhancement cardiovascular magnetic resonance.

Journal Article Circulation · January 16, 2007 BACKGROUND: An ultrafast, delayed contrast-enhancement cardiovascular magnetic resonance technique that can acquire subsecond, "snapshot" images during free breathing (subsecond) is becoming widely available. This technique provides myocardial infarction ( ... Full text Link to item Cite

Effective dose determination using an anthropomorphic phantom and metal oxide semiconductor field effect transistor technology for clinical adult body multidetector array computed tomography protocols.

Journal Article J Comput Assist Tomogr · 2007 PURPOSE: To determine the organ doses and total body effective dose (ED) delivered to an anthropomorphic phantom by multidetector array computed tomography (MDCT) when using standard clinical adult body imaging protocols. MATERIALS AND METHODS: Metal oxide ... Full text Link to item Cite

Radiation dose to the female breast from 16-MDCT body protocols.

Journal Article AJR Am J Roentgenol · June 2006 OBJECTIVE: The objective of our study was to determine the radiation dose to the female breast from current 16-MDCT body examinations. MATERIALS AND METHODS: Metal oxide semiconductor field effect transistor (MOSFET) detectors were placed in four quadrants ... Full text Link to item Cite

Radiation dose to the fetus from body MDCT during early gestation.

Journal Article AJR Am J Roentgenol · March 2006 OBJECTIVE: The purpose of our study was to determine radiation dose to the fetus at early gestation when contemporary MDCT scanners are used for common clinical indications. MATERIALS AND METHODS: Anthropomorphic phantoms were constructed to reflect a preg ... Full text Link to item Cite

A 73-year-old woman with a cough.

Journal Article Chest · August 2005 Full text Link to item Cite

Practical injection-rate CT perfusion imaging: deconvolution-derived hemodynamics in a case of stroke.

Journal Article Neuroradiology · March 2001 Previously reported methods of dynamic, contrast-enhanced, CT perfusion imaging in acute stroke have been promising but substantially limited by their dependence on very rapid rates of injection (typically 10-20 ml/s in an arm vein). Newly available deconv ... Full text Link to item Cite

Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?

Journal Article Chem Biol · October 1997 The overexpression of specific transport proteins in the membrane of many cancer cells renders these cells resistant to many therapeutic drugs. Some lipid-modified cysteine compounds inhibit one drug-transporting protein, indicating the potential of develo ... Full text Link to item Cite

Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool.

Journal Article Am J Physiol · January 1992 We have investigated the role of the intracellular Ca2+ pool in regulating Ca2+ entry into vascular endothelial cells. The intracellular Ca2+ pool was mobilized using either thapsigargin (TG) or 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ), inhibitors ... Full text Link to item Cite