Scholars@Duke
Manisha Palta

Manisha Palta

Associate Professor of Radiation Oncology
Radiation Oncology
manisha.palta@duke.edu
Dept of Radiation Oncology, BOX_3085, Durham, NC 27710

Selected Publications

An Organized Approach to Ablative Radiation Therapy.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2025 Full text Link to item Cite

Stereotactic body radiotherapy with or without selective dismutase mimetic in pancreatic adenocarcinoma: an adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial.

Journal Article Lancet Oncol · December 2023 BACKGROUND: Stereotactic body radiotherapy (SBRT) has the potential to ablate localised pancreatic ductal adenocarcinoma. Selective dismutase mimetics sensitise tumours while reducing normal tissue toxicity. This trial was designed to establish the efficac ... Full text Link to item Cite

Comparing Survival After Resection, Ablation, and Radiation in Small Intrahepatic Cholangiocarcinoma.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Hepatectomy is the cornerstone of curative-intent treatment for intrahepatic cholangiocarcinoma (ICC). However, in patients unable to be resected, data comparing efficacy of alternatives including thermal ablation and radiation therapy (RT) rem ... Full text Open Access Link to item Cite

NCCN Guidelines® Insights: Biliary Tract Cancers, Version 2.2023.

Journal Article J Natl Compr Canc Netw · July 2023 In 2023, the NCCN Guidelines for Hepatobiliary Cancers were divided into 2 separate guidelines: Hepatocellular Carcinoma and Biliary Tract Cancers. The NCCN Guidelines for Biliary Tract Cancers provide recommendations for the evaluation and comprehensive c ... Full text Link to item Cite

CT-derived body composition measurements as predictors for neoadjuvant treatment tolerance and survival in gastroesophageal adenocarcinoma.

Journal Article Abdom Radiol (NY) · January 2023 PURPOSE: Treatment for gastroesophageal adenocarcinomas can result in significant morbidity and mortality. The purpose of this study is to supplement methods for choosing treatment strategy by assessing the relationship between CT-derived body composition, ... Full text Link to item Cite

Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis.

Journal Article Cancers (Basel) · May 13, 2022 PURPOSE: We previously reported on the clinical outcomes of treating oligometastases with radiation using an elective simultaneous integrated boost technique (SIB), delivering higher doses to known metastases and reduced doses to adjacent bone or nodal bas ... Full text Link to item Cite

Transfer learning for fluence map prediction in adrenal stereotactic body radiation therapy.

Conference Phys Med Biol · December 6, 2021 Objective:To design a deep transfer learning framework for modeling fluence map predictions for stereotactic body radiation therapy (SBRT) of adrenal cancer and similar sites that usually have a small number of cases.Approach:We developed a transfer learni ... Full text Link to item Cite

Machine Learning Algorithm Prospectively Predicts Survival for High-Risk Patients Undergoing Radiotherapy: A Survival Analysis of SHIELD-RT.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Mortality prediction is critical to appropriate cancer care planning. This has become a topic of interest, with machine learning (ML) tools demonstrating accurate binary predictions for mortality at specific time points. There ... Full text Cite

Oligometastases Treated With an Elective Simultaneous Integrated Boost Have Reduced Marginal Recurrence Rates.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Radiation is increasingly used to treat oligometastatic patients (OM). Following metastasis directed radiation therapy, progression in nearby nodal basins or bones is common. We previously reported clinical outcomes of OM treat ... Full text Cite

Survey of Healthcare Providers Utilization and Perception of Telehealth On-Treatment Visits During COVID-19 Pandemic.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Patients undergoing radiotherapy during the COVID-19 pandemic have experienced unique changes to care, including increased use of telehealth for radiotherapy on-treatment visits (OTVs). The objective of this study was to determ ... Full text Cite

The Role of Hypofractionated Radiation Therapy in the Management of Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Management of HCC without surgical resection or transplantation is poorly defined with no standard. Stereotactic body radiation therapy (SBRT) or hypofractionated image-guided radiotherapy (HIGRT), is an evolving, non-invasive, ... Full text Cite

Toxicity and Dosimetric Parameters of Ablative Radiation Therapy in the Management of Patients with Child-Pugh B/C Liver Function and Unresectable Hepatocellular Carcinoma (HCC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)To date there is no clear standard non-surgical therapeutic option for HCC patients. Ablative radiation therapy (SBRT/HIGRT) is an emerging non-invasive treatment for patients with HCC. However, there is concern about the risk ... Full text Cite

Evolving role of an oncology telehealth nurse at an NCI-designated cancer institute.

Conference Journal of Clinical Oncology · October 1, 2021 277 Background: Oncology telehealth (TH) services may improve access, mitigate care delays, and augment care in select settings. However, logistical and workflow barriers hinder the sustainable adoption of TH services by provider ... Full text Cite

Impact of machine learning-directed on-treatment evaluations on cost of acute care visits: Economic analysis of SHIELD-RT.

Conference Journal of Clinical Oncology · May 20, 2021 1509 Background: SHIELD-RT was a randomized controlled quality improvement study (NCT03775265) that implemented electronic health record-based machine learning (ML) to direct supplemental visits for high risk (HR) patients underg ... Full text Cite

Maximizing Tumor Control and Limiting Complications With Stereotactic Body Radiation Therapy for Pancreatic Cancer.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2021 PURPOSE: Stereotactic body radiation therapy (SBRT) and stereotactic ablative body radiation therapy is being increasingly used for pancreatic cancer (PCa), particularly in patients with locally advanced and borderline resectable disease. A wide variety of ... Full text Link to item Cite

Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

Journal Article J Natl Compr Canc Netw · May 1, 2021 The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging, treatment, and management of hepatocellular carcinoma (HCC), gallbladder cancer, and cancer of the bile ducts (intrahepatic and extrahepatic cholangiocarcinoma). Due ... Full text Link to item Cite

An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2021 PURPOSE: Pancreas stereotactic body radiation therapy (SBRT) treatment planning requires planners to make sequential, time-consuming interactions with the treatment planning system to reach the optimal dose distribution. We sought to develop a reinforcemen ... Full text Link to item Cite

Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma.

Journal Article Clin Cancer Res · March 1, 2021 PURPOSE: In this prospective trial, we sought to assess the feasibility of concurrent administration of ipilimumab and radiation as adjuvant, neoadjuvant, or definitive therapy in patients with regionally advanced melanoma. PATIENTS AND METHODS: Twenty-fou ... Full text Link to item Cite

Deep Learning-Based Fluence Map Prediction for Pancreas Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a challenging task, especially with simultaneous integrated boost treatment approaches. We propose a deep learning (DL) framework to accurately predict fluence maps from ... Full text Link to item Cite

Natural language processing for abstraction of cancer treatment toxicities: accuracy versus human experts.

Journal Article JAMIA Open · December 2020 OBJECTIVES: Expert abstraction of acute toxicities is critical in oncology research but is labor-intensive and variable. We assessed the accuracy of a natural language processing (NLP) pipeline to extract symptoms from clinical notes compared to physicians ... Full text Link to item Cite

System for High-Intensity Evaluation During Radiation Therapy (SHIELD-RT): A Prospective Randomized Study of Machine Learning-Directed Clinical Evaluations During Radiation and Chemoradiation.

Journal Article J Clin Oncol · November 1, 2020 PURPOSE: Patients undergoing outpatient radiotherapy (RT) or chemoradiation (CRT) frequently require acute care (emergency department evaluation or hospitalization). Machine learning (ML) may guide interventions to reduce this risk. There are limited prosp ... Full text Link to item Cite

Interrater Reliability in Toxicity Identification: Limitations of Current Standards.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2020 PURPOSE: The National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) v5.0 is the standard for oncology toxicity encoding and grading, despite limited validation. We assessed interrater reliability (IRR) in multireviewer toxicity id ... Full text Link to item Cite

Mind the gap: Gendered publication trends in oncology.

Journal Article Cancer · June 15, 2020 BACKGROUND: Investigating scientific publication trends in the field of oncology may highlight opportunities for improved representation, mentorship, collaboration, and advancement for women. METHODS: We conducted a bibliometric analysis of Annals of Surgi ... Full text Link to item Cite

Evaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature.

Journal Article J Gastrointest Oncol · April 2020 BACKGROUND: Colorectal cancer is the third most common cancer in the United States and associated with significant morbidity and mortality. Within colorectal cancer histologies, squamous cell carcinomas (SCC) are rare compared to adenocarcinomas, with only ... Full text Link to item Cite

The Treatment of Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis.

Journal Article Am Soc Clin Oncol Educ Book · March 2020 Hepatocellular carcinoma (HCC) is the sixth most common cancer and third leading cause of cancer-related death worldwide. HCC is also is a tumor with a distinct ability to invade and grow within the hepatic vasculature. Approximately 20% of patients with H ... Full text Link to item Cite

Survival Advantage With Adjuvant Chemotherapy for Locoregionally Advanced Rectal Cancer: A Veterans Health Administration Analysis.

Journal Article J Natl Compr Canc Netw · January 2020 BACKGROUND: Adjuvant chemotherapy (AC) after chemoradiation (CRT) and surgery for locoregionally advanced rectal cancer (LARC) is a standard of care in the United States. This study examined the role, optimal regimen, and duration of AC using data from the ... Full text Link to item Cite

Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers.

Journal Article Front Oncol · 2020 Purpose: To perform a multi-institutional analysis of patients with synchronous prostate and rectosigmoid cancers. Materials and Methods: A retrospective review of Duke University and Durham Veterans Affairs Medical Center records was performed for men wit ... Full text Link to item Cite

Fluence Map Prediction for Fast Pancreas Stereotactic Body Radiation Therapy (SBRT) Planning via Deep Learning

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2020 Cite

Fluence Map Prediction Using Deep Learning Models - Direct Plan Generation for Pancreas Stereotactic Body Radiation Therapy.

Journal Article Front Artif Intell · 2020 Purpose: Treatment planning for pancreas stereotactic body radiation therapy (SBRT) is a difficult and time-consuming task. In this study, we aim to develop a novel deep learning framework to generate clinical-quality plans by direct prediction of fluence ... Full text Open Access Link to item Cite

Local Tumor Control and Patient Outcome Using Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: iRECIST as a Potential Substitute for Traditional Criteria.

Journal Article AJR Am J Roentgenol · December 2019 OBJECTIVE. The purpose of this study was to investigate whether, compared with traditional criteria, the modified Response Evaluation Criteria in Solid Tumors version 1.1 for immune-based therapeutics (iRECIST) improves prediction of local tumor control an ... Full text Link to item Cite

Accuracy of a Natural Language Processing Pipeline to Identify Patient Symptoms during Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · September 2019 Full text Cite

Mind the Gap: Gendered Publication Trends in Academic Oncology

Conference International Journal of Radiation Oncology*Biology*Physics · September 2019 Full text Cite

In Reply to Gerard.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2019 Full text Link to item Cite

Role of pelvic chemoradiation therapy in patients with initially metastatic anal canal cancer: A National Cancer Database review.

Journal Article Cancer · June 15, 2019 BACKGROUND: Although the management of localized anal canal squamous cell carcinomas is well established, the role of pelvic chemoradiation (CRT) in the treatment of patients presenting with synchronous metastatic (stage IV) disease is poorly defined. This ... Full text Link to item Cite

Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: Current State and Future Opportunities.

Journal Article Dig Dis Sci · April 2019 Hepatocellular carcinoma is a rising cause of morbidity and mortality in the USA and around the world. Surgical resection and liver transplantation are the preferred management strategies; however, less than 30% of patients are eligible for surgery. Stereo ... Full text Link to item Cite

Guidelines Insights: Hepatobiliary Cancers, Version 2.2019.

Journal Article J Natl Compr Canc Netw · April 1, 2019 The NCCN Guidelines for Hepatobiliary Cancers provide treatment recommendations for cancers of the liver, gallbladder, and bile ducts. The NCCN Hepatobiliary Cancers Panel meets at least annually to review comments from reviewers within their institutions, ... Full text Link to item Cite

Long-term Clinical Outcomes of Nonoperative Management With Chemoradiotherapy for Locally Advanced Rectal Cancer in the Veterans Health Administration.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2019 PURPOSE: Standard therapy for locally advanced rectal cancer includes neoadjuvant chemoradiation and surgery. Complete response (CR) rates after chemoradiation can be as high as 29%, suggesting that nonoperative management (NOM) may be reasonable with appr ... Full text Link to item Cite

Multi-institutional analysis of synchronous prostate and rectosigmoid cancers.

Conference Journal of Clinical Oncology · March 1, 2019 33 Background: Synchronous prostate cancer (PC) and rectosigmoid (RS) cancer (RSC) is a challenging clinical situation. Methods: A retrospective review of Duke University and Durham VA charts was performed for men with adenocarci ... Full text Cite

Hypofractionated Image-Guided Radiation Therapy With Simultaneous-Integrated Boost Technique for Limited Metastases: A Multi-Institutional Analysis.

Journal Article Front Oncol · 2019 Purpose: To perform a multi-institutional analysis following treatment of limited osseous and/or nodal metastases in patients using a novel hypofractionated image-guided radiotherapy with simultaneous-integrated boost (HIGRT-SIB) technique. Methods: Consec ... Full text Open Access Link to item Cite

A Collimator Setting Optimization Algorithm for Dual-Arc Volumetric Modulated Arc Therapy in Pancreas Stereotactic Body Radiation Therapy

Conference Technology in Cancer Research and Treatment · January 1, 2019 Purpose: To optimize collimator setting to improve dosimetric quality of pancreas volumetric modulated arc therapy plan for stereotactic body radiation therapy. Materials and Methods: Fifty-five volumetric modulated arc therapy cases in stereotactic body r ... Full text Cite

A Collimator Setting Optimization Algorithm for Dual-Arc Volumetric Modulated Arc Therapy in Pancreas Stereotactic Body Radiation Therapy.

Journal Article Technol Cancer Res Treat · January 1, 2019 PURPOSE: To optimize collimator setting to improve dosimetric quality of pancreas volumetric modulated arc therapy plan for stereotactic body radiation therapy. MATERIALS AND METHODS: Fifty-five volumetric modulated arc therapy cases in stereotactic body r ... Full text Open Access Link to item Cite

Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.

Journal Article Pract Radiat Oncol · 2019 PURPOSE: This guideline systematically reviews the evidence for treatment of pancreatic cancer with radiation in the adjuvant, neoadjuvant, definitive, and palliative settings and provides recommendations on indications and technical considerations. METHOD ... Full text Link to item Cite

The multidisciplinary management of early-stage cervical esophageal cancer

Chapter · January 1, 2019 Cervical esophageal cancer (CEC) was historically treated with primary surgery, typically a pharyngo-laryngo-esophagectomy (PLE), a morbid procedure with substantial impact on a patient’s long-term quality of life. More recently, a paradigm shift has occur ... Full text Cite

Total Neoadjuvant Therapy (TNT) in Rectal Cancer

Journal Article Current Colorectal Cancer Reports · December 1, 2018 Purpose of Review: This review summarizes the relevant literature on the use of total neoadjuvant therapy (TNT) for patients with locally advanced rectal cancer. It highlights the most notable literature published and briefly discusses future directions. R ... Full text Cite

Predicting Emergency Visits and Hospital Admissions During Radiation and Chemoradiation: An Internally Validated Pretreatment Machine Learning Algorithm.

Journal Article JCO Clin Cancer Inform · December 2018 PURPOSE: Patients undergoing radiotherapy (RT) or chemoradiotherapy (CRT) may require emergency department evaluation or hospitalization. Early identification may direct preventative supportive care, improving outcomes and reducing health care costs. We de ... Full text Link to item Cite

Association of Interim FDG-PET Imaging During Chemoradiation for Squamous Anal Canal Carcinoma With Recurrence.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: Imaging parameters from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) before and after chemoradiation therapy (CRT) for anal canal cancer correlate with clinical outcomes. This prospective, hypothesis-generating pilot study inv ... Full text Link to item Cite

Intratreatment Response Assessment With 18F-FDG PET: Correlation of Semiquantitative PET Features With Pathologic Response of Esophageal Cancer to Neoadjuvant Chemoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2018 PURPOSE: This prospective study seeks to extract semiquantitative positron emission tomography (PET) features from 18F-fluorodeoxyglucose PET scans performed before and during neoadjuvant chemoradiotherapy for esophageal cancer and to compare their accurac ... Full text Link to item Cite

The role of external beam radiotherapy in the treatment of hepatocellular cancer.

Journal Article Cancer · September 1, 2018 Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long-term survival has improved from 3% in 1970 to an 18% 5-year survival rate today. This is likely because of the introduction of well tolerated ... Full text Link to item Cite

The Selective Use of Radiation Therapy in Rectal Cancer Patients.

Journal Article Curr Oncol Rep · April 11, 2018 PURPOSE OF REVIEW: Colorectal cancer has a high global incidence, and standard treatment employs a multimodality approach. In addition to cure, minimizing treatment-related toxicity and improving the therapeutic ratio is a common goal. The following articl ... Full text Link to item Cite

Role of radiotherapy in locally advanced pancreatic cancer

Chapter · April 11, 2018 Pancreatic cancer carries a poor prognosis regardless of stage, and incidence and death rates are increasing. Pancreatic cancer is divided into four general categories, resectable, borderline resectable, locally advanced/unresectable, and metastatic. Only ... Full text Cite

Role of adjuvant chemotherapy following chemoradiation and surgery for locoregionally advanced rectal cancer: A Veterans Health Administration analysis.

Conference Journal of Clinical Oncology · February 1, 2018 741 Background: Adjuvant chemotherapy (AC) following chemoradiation (CRT) and total mesorectal excision (TME) for locoregionally advanced rectal cancer (LARC) is a standard of care in the United States despite limited data. The p ... Full text Cite

Pancreatic gross tumor volume contouring on computed tomography (CT) compared with magnetic resonance imaging (MRI): Results of an international contouring conference.

Journal Article Pract Radiat Oncol · 2018 PURPOSE: Accurate identification of the gross tumor volume (GTV) in pancreatic adenocarcinoma is challenging. We sought to understand differences in GTV delineation using pancreatic computed tomography (CT) compared with magnetic resonance imaging (MRI). M ... Full text Link to item Cite

The Impact of Biologically Equivalent Dose on Tumor Control in Unresectable Hepatocellular Carcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Non-operative Management for Locally Advanced Rectal Cancer in the Veterans Health Administration

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

The Role of Chemoradiation Therapy in Initially Metastatic Anal Canal Cancer Patients: A National Cancer Database Review

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2017 Link to item Cite

Neoadjuvant Chemoradiation Therapy in Nonpancreatic Periampullary Carcinoma: An Institutional Experience

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2017 Link to item Cite

Association Between Incomplete Neoadjuvant Radiotherapy and Survival for Patients With Locally Advanced Rectal Cancer.

Journal Article JAMA Surg · June 1, 2017 IMPORTANCE: Failing to complete chemotherapy adversely affects survival in patients with colorectal cancer. However, the effect of incomplete delivery of neoadjuvant radiotherapy is unclear. OBJECTIVE: To determine whether incomplete radiotherapy delivery ... Full text Link to item Cite

Total neoadjuvant therapy for rectal cancer: An emerging option.

Journal Article Cancer · May 1, 2017 The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metasta ... Full text Link to item Cite

NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017.

Journal Article J Natl Compr Canc Netw · May 2017 The NCCN Guidelines for Hepatobiliary Cancers provide treatment recommendations for cancers of the liver, gallbladder, and bile ducts. The NCCN Hepatobiliary Cancers Panel meets at least annually to review comments from reviewers within their institutions, ... Full text Link to item Cite

Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States.

Journal Article Cancer · April 15, 2017 BACKGROUND: Short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT) are accepted neoadjuvant treatments of rectal cancer. In the current study, the authors surveyed US radiation oncologists to assess practice patterns and attitudes reg ... Full text Link to item Cite

Role of Chemotherapy and Radiation Therapy in the Management of Gastric Adenocarcinoma.

Journal Article Surg Clin North Am · April 2017 Gastric adenocarcinoma is the fifth most common cancer worldwide and is often diagnosed at a late stage with nearly 50% of patients having locally advanced, unresectable, or metastatic disease at the time of presentation. Efforts to improve outcomes in pat ... Full text Link to item Cite

Retrospective four-dimensional magnetic resonance imaging with image-based respiratory surrogate: a sagittal-coronal-diaphragm point of intersection motion tracking method.

Journal Article J Med Imaging (Bellingham) · April 2017 A four-dimensional magnetic resonance imaging (4-D-MRI) technique with Sagittal-Coronal-Diaphragm Point-of-Intersection (SCD-PoI) as a respiratory surrogate is proposed. To develop an image-based respiratory surrogate, the SCD-PoI motion tracking method is ... Full text Link to item Cite

Four-dimensional diffusion-weighted MR imaging (4D-DWI): a feasibility study.

Journal Article Med Phys · February 2017 PURPOSE: Diffusion-weighted Magnetic Resonance Imaging (DWI) has been shown to be a powerful tool for cancer detection with high tumor-to-tissue contrast. This study aims to investigate the feasibility of developing a four-dimensional DWI technique (4D-DWI ... Full text Link to item Cite

Interim FDG-PET imaging during neoadjuvant chemoradiotherapy for esophageal cancer: Correlation with pathologic response.

Conference Journal of Clinical Oncology · February 1, 2017 175 Background: In this prospective study we evaluated whether changes in metabolic tumor parameters on interim flurodeoxyglucose positron emission tomography (FDG-PET) performed during neoadjuvant chemoradiotherapy (CRT) for eso ... Full text Cite

Triphasic contrast enhanced CT simulation with bolus tracking for pancreas SBRT target delineation.

Journal Article Pract Radiat Oncol · 2017 PURPOSE: Bolus-tracked multiphasic contrast computed tomography (CT) is often used in diagnostic radiology to enhance the visibility of pancreas tumors, but is uncommon in radiation therapy pancreas CT simulation, and its impact on gross tumor volume (GTV) ... Full text Link to item Cite

The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer.

Journal Article Ann Surg Oncol · October 2016 BACKGROUND: The optimal approach to patients with locally recurrent, non-metastatic rectal cancer is unclear. This study evaluates the outcomes and toxicity associated with pelvic re-irradiation. METHODS: Patients undergoing re-irradiation for locally recu ... Full text Link to item Cite

The Use of Reirradiation in Locally Recurrent, Nonmetastatic Rectal Cancer.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 Full text Link to item Cite

Development of an Ultra-Fast, High-Quality Whole-Breast Radiation Therapy Treatment Planning System

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · October 1, 2016 Link to item Cite

SU-F-T-544: Development of a Clinically Feasible Workflow of 4D MRI-Based Treatment Planning for Liver SBRT.

Journal Article Med Phys · June 2016 PURPOSE: To develop a clinically feasible workflow of 4D MRI-based treatment planning for liver SBRT. METHODS: A clinical workflow based on 4D MRI for liver SBRT was designed to largely simulate the same procedure as 4D CT for lung SBRT. Key features of th ... Full text Link to item Cite

SU-F-J-103: Assessment of Liver Tumor Contrast for Radiation Therapy: Inter-Patient and Inter-Sequence Variability.

Journal Article Med Phys · June 2016 PURPOSE: To determine the variation in tumor contrast between different MRI sequences and between patients for the purpose of MRI-based treatment planning. METHODS: Multiple MRI scans of 11 patients with cancer(s) in the liver were included in this IRB-app ... Full text Link to item Cite

WE-AB-209-05: Development of an Ultra-Fast High Quality Whole Breast Radiotherapy Treatment Planning System.

Journal Article Med Phys · June 2016 PURPOSE: To enable near-real-time (<20sec) and interactive planning without compromising quality for whole breast RT treatment planning using tangential fields. METHODS: Whole breast RT plans from 20 patients treated with single energy (SE, 6MV, 10 patient ... Full text Link to item Cite

In Reply to Fiorino and Cozzarini.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2016 Full text Link to item Cite

Role of Adjuvant Radiotherapy in Locally Advanced Colonic Carcinoma in the Modern Chemotherapy Era.

Journal Article Ann Surg Oncol · March 2016 BACKGROUND: The role of adjuvant radiation therapy (RT) in the treatment of resected, locally advanced colon cancer is unclear. One randomized controlled trial (Intergroup-0130) addressed this question but failed to meet its accrual goals. Since this trial ... Full text Link to item Cite

Image Guided Hypofractionated Postprostatectomy Intensity Modulated Radiation Therapy for Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2016 PURPOSE: Hypofractionated radiation therapy (RT) has promising long-term biochemical relapse-free survival (bRFS) with comparable toxicity for definitive treatment of prostate cancer. However, data reporting outcomes after adjuvant and salvage postprostate ... Full text Link to item Cite

Effect of combined neoadjuvant chemoradiation on overall survival for patients with locally advanced rectal cancer.

Conference Journal of Clinical Oncology · February 1, 2016 657 Background: Prospective randomized trials have demonstrated that neoadjuvant chemoradiation improves local control and results in a higher rate of sphincter-sparing surgery for patients with locally advanced rectal cancer. Ho ... Full text Cite

Nonoperative management of rectal cancer.

Journal Article Cancer · January 1, 2016 Surgery has long been the primary curative modality for localized rectal cancer. Neoadjuvant chemoradiation has significantly improved local control rates and, in a significant minority, eradicated all disease. Patients who achieve a pathologic complete re ... Full text Link to item Cite

A current perspective on stereotactic body radiation therapy for pancreatic cancer.

Journal Article Onco Targets Ther · 2016 Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is ... Full text Open Access Link to item Cite

Adjuvant radiation therapy for pancreatic cancer: a review of the old and the new.

Journal Article J Gastrointest Oncol · August 2015 Surgery represents the only potential curative treatment option for patients diagnosed with pancreatic adenocarcinoma. Despite aggressive surgical management for patients deemed to be resectable, rates of local recurrence and/or distant metastases remain h ... Full text Link to item Cite

Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2015 PURPOSE: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for ... Full text Link to item Cite

Human papillomavirus tumor infection in esophageal squamous cell carcinoma.

Journal Article J Gastrointest Oncol · June 2015 The association between human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) has been recognized for over three decades. Recently, multiple meta-analyses have drawn upon existing literature to assess the strength of the HPV-ESCC linkage ... Full text Link to item Cite

TH-CD-207-09: Retrospective 4D-MRI with a Novel Image-Based Surrogate: A Sagittal-Coronal-Diaphragm Point of Intersection (SCD-PoI) Motion Tracking Method.

Journal Article Med Phys · June 2015 PURPOSE: The unreliable stability of internal respiratory surrogates and inconvenience of external respiratory surrogates for current retrospective 4D-MRI techniques largely affects the image quality of 4D-MRI. This study aims at developing image-based sur ... Full text Link to item Cite

SU-F-303-13: Initial Evaluation of Four Dimensional Diffusion- Weighted MRI (4D-DWI) and Its Effect On Apparent Diffusion Coefficient (ADC) Measurement.

Journal Article Med Phys · June 2015 PURPOSE: Diffusion-weighted imaging(DWI) has been shown to have superior tumor-to-tissue contrast for cancer detection.This study aims at developing and evaluating a four dimensional DWI(4D-DWI) technique using retrospective sorting method for imaging resp ... Full text Link to item Cite

SU-E-J-223: A BOLD Contrast Imaging Sequence to Evaluate Oxygenation Changes Due to Breath Holding for Breast Radiotherapy: A Pilot Study.

Journal Article Med Phys · June 2015 PURPOSE: To develop a robust MRI sequence to measure BOLD breath hold induced contrast in context of breast radiotherapy. METHODS: Two sequences were selected from prior studies as candidates to measure BOLD contrast attributable to breath holding within t ... Full text Link to item Cite

Abstract P2-12-07: The association between exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy

Conference Cancer Research · May 1, 2015 AbstractPurpose/Objectives: RT is associated with acute treatment-related complications that can lead to poor quality of life (QOL) and fatigue. Exercise has been shown in other cancer treatment settings to ... Full text Cite

Abstract P1-15-10: Low utilization of hypofractionated radiotherapy for the treatment of early-stage breast cancer in the US

Conference Cancer Research · May 1, 2015 AbstractBackground: Large randomized controlled trials have shown that hypofractionated whole breast irradiation (HF-WBI) is not inferior to or more toxic than conventionally fractionated whole breast irradi ... Full text Cite

Abstract P1-10-02: Adjuvant radiation after lumpectomy: A cost comparison of treatment patterns in 43,247 women from the National Cancer Data Base

Conference Cancer Research · May 1, 2015 AbstractBACKGROUND: Breast cancer treatment contributes the greatest proportion of cancer-related health care spending in the United States. Locoregional therapy comprises a significant share of these costs. ... Full text Cite

The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: changes in practice patterns after publication of Cancer and Leukemia Group B 9343.

Conference Cancer · January 15, 2015 BACKGROUND: The Cancer and Leukemia Group B (CALGB) 9343 randomized phase 3 trial established lumpectomy and adjuvant therapy with tamoxifen alone, rather than both radiotherapy and tamoxifen, as a reasonable treatment course for women aged >70 years with ... Full text Link to item Cite

Exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: Radiation therapy is associated with acute treatment-related complications that can lead to decreased quality of life (QOL). Exercise has been shown in other cancer treatment settings to improve negative outcomes. We conducted a prospective pilot ... Full text Link to item Cite

A phase 1 trial of preoperative partial breast radiation therapy: Patient selection, target delineation, and dose delivery.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: Diffusion of accelerated partial breast irradiation into clinical practice is limited by the need for specialized equipment and training. The accessible external beam technique yields unacceptable complication rates, likely from large postoperativ ... Full text Link to item Cite

Anal canal cancer

Chapter · January 1, 2015 Radiation therapy with concurrent chemotherapy is the standard treatment for patients with nonmetastatic squamous cell carcinoma of the anal canal. In the studies that established this approach, high rates of locoregional control have been reported, but th ... Full text Cite

The multidisciplinary management 11 of early stage cervical esophageal cancer

Chapter · January 1, 2015 Cancer development in the cervical portion of the esophagus presents a unique challenge to management given the close proximity of critical structures in the head and neck. Cervical esophageal cancer (CEC) was historically approached with primarysurgery, p ... Full text Cite

Colon Cancer

Chapter · January 1, 2015 Full text Cite

Intraoperative Irradiation

Chapter · January 1, 2015 Full text Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma.

Journal Article J Gastrointest Oncol · December 2014 BACKGROUND: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Link to item Cite

Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience.

Journal Article J Gastrointest Oncol · December 2014 BACKGROUND: Ampullary adenocarcinoma is a rare malignancy associated with a relatively favorable prognosis. Given high survival rates in stage I patients reported in small series with surgery alone, adjuvant chemoradiotherapy (CRT) has traditionally been r ... Full text Link to item Cite

Intraoperative radiotherapy in the treatment of gastrointestinal malignancies

Journal Article Translational Cancer Research · December 1, 2014 Intraoperative radiotherapy (IORT) is a technique that allows delivery of a single high dose of radiation to a target volume during surgery. Where conventional external beam radiation therapy (EBRT) is limited by the normal tissue tolerance of abdominal an ... Full text Cite

Is diaphragm motion a good surrogate for liver tumor motion?

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2014 PURPOSE: To evaluate the relationship between liver tumor motion and diaphragm motion. METHODS AND MATERIALS: Fourteen patients with hepatocellular carcinoma (10 of 14) or liver metastases (4 of 14) undergoing radiation therapy were included in this study. ... Full text Link to item Cite

Investigation of sagittal image acquisition for 4D-MRI with body area as respiratory surrogate.

Journal Article Med Phys · October 2014 PURPOSE: The authors have recently developed a novel 4D-MRI technique for imaging organ respiratory motion employing cine acquisition in the axial plane and using body area (BA) as a respiratory surrogate. A potential disadvantage associated with axial ima ... Full text Link to item Cite

Radiosensitive orbital metastasis as presentation of occult colonic adenocarcinoma.

Journal Article BMJ Case Rep · September 19, 2014 An 82-year-old man presented with progressive right frontal headaches. The patient's history was significant for benign polyps on surveillance colonoscopy 2 years prior, without high-grade dysplasia or carcinoma. MRI revealed an enhancing lesion arising wi ... Full text Link to item Cite

Short-course versus long-course chemoradiation in rectal cancer--time to change strategies?

Journal Article Curr Treat Options Oncol · September 2014 There is significant debate regarding the optimal neoadjuvant regimen for resectable rectal cancer patients. Short-course radiotherapy, a standard approach throughout most of northern Europe, is generally defined as 25 Gy in 5 fractions over the course of ... Full text Link to item Cite

Preoperative Partial Breast Radiation Therapy: One Year Outcomes and Radiation-Induced Changes in Gene Expression

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Definitive Chemoradiation Therapy for Cervical Esophageal Carcinoma: A Single-Institution Experience

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Low-Dose Consolidation Radiation Therapy for Early-Stage Unfavorable Hodgkin Lymphoma

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Patterns of recurrence after trimodality therapy for esophageal cancer.

Journal Article Cancer · July 15, 2014 BACKGROUND: Patterns of failure after neoadjuvant chemoradiotherapy and surgery for esophageal cancer are poorly defined. METHODS: All patients in the current study were treated with trimodality therapy for nonmetastatic esophageal cancer from 1995 to 2009 ... Full text Link to item Cite

Radiotherapy for Gastrointestinal Malignancies

Chapter · June 20, 2014 This chapter talks about four case studies of radiotherapy for gastrointestinal malignancies. One of the case study, a 65-year-old female presents with painless jaundice and diarrhea for 1 month. Labs show an elevation in liver function tests and total bil ... Full text Cite

MO-G-18C-04: Improved Synthetic 4D-MRI Using Linear Polynomial Fitting Model.

Journal Article Med Phys · June 2014 PURPOSE: To reduce deformable image registration error by fitting the displacement vector field (DVF) to smooth the motion trajectory of each pixel in synthetic 4D-MRI. METHODS: Five patients with cancers in the liver were enrolled in this study. For a 4D ... Full text Link to item Cite

SU-E-J-192: Verification of 4D-MRI Internal Target Volume Using Cine MRI.

Conference Med Phys · June 2014 PURPOSE: To investigate the accuracy of 4D-MRI in determining the Internal Target Volume (ITV) used in radiation oncology treatment planning of liver cancers. Cine MRI is used as the standard baseline in establishing the feasibility and accuracy of 4D-MRI ... Full text Link to item Cite

MO-C-17A-02: A Novel Method for Evaluating Hepatic Stiffness Based On 4D-MRI and Deformable Image Registration.

Journal Article Med Phys · June 2014 PURPOSE: Quantitative imaging of hepatic stiffness has significant potential in radiation therapy, ranging from treatment planning to response assessment. This study aims to develop a novel, noninvasive method to quantify liver stiffness with 3D strains li ... Full text Link to item Cite

SU-E-J-68: Evaluation of Liver Deformation During Breathing Using Deformable Image Registration: A Comparison Between 4D CT and 4D MRI.

Journal Article Med Phys · June 2014 PURPOSE: It is of clinical interest to study liver deformation during breathing by applying deformable image registration (DIR) on respiratory correlated 4D images. This study aims to evaluate and compare the accuracy of DIR-derived liver deformation based ... Full text Link to item Cite

WE-G-18C-06: Is Diaphragm Motion a Good Surrogate for Liver Tumor Motion?

Journal Article Med Phys · June 2014 PURPOSE: To investigate whether diaphragm motion is a good surrogate for liver tumor motion by comparing their motion trajectories obtained from cine-MRI. METHODS: Fourteen patients with hepatocellular carcinoma (10/14) or liver metastases (4/14) undergoin ... Full text Link to item Cite

SU-E-J-182: A Feasibility Study Evaluating Automatic Identification of Gross Tumor Volume for Breast Cancer Radiotherapy Using Dynamic Contrast-Enhanced MR Imaging.

Journal Article Med Phys · June 2014 PURPOSE: To develop a computerized pharmacokinetic model-free Gross Tumor Volume (GTV) segmentation method based on dynamic contrastenhanced MRI (DCE-MRI) data that can improve physician GTV contouring efficiency. METHODS: 12 patients with biopsy-proven ea ... Full text Link to item Cite

TH-E-BRF-10: Interim Esophageal Cancer Response Assessment Via 18FDG-PET Scanning During Radiation Therapy.

Journal Article Med Phys · June 2014 PURPOSE: Local failure occurs in a large proportion of esophageal cancer patients treated with chemoradiation. The treatment strategy for non-responders could potentially be modified if they are identified during therapy. This work investigates the utility ... Full text Link to item Cite

SU-D-9A-02: Relative Effects of Threshold Choice and Spatial Resolution Modeling On SUV and Volume Quantification in F18-FDG PET Imaging of Anal Cancer Patients.

Journal Article Med Phys · June 2014 PURPOSE: PET imaging with F18-FDG is utilized for treatment planning, treatment assessment, and prognosis. A region of interest (ROI) encompassing the tumor may be determined on the PET image, often by a threshold T on the PET standard uptake values (SUVs) ... Full text Link to item Cite

Stereotactic body radiotherapy: a critical review for nonradiation oncologists.

Journal Article Cancer · April 1, 2014 Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate de ... Full text Link to item Cite

The role of intraoperative radiation therapy in patients with pancreatic cancer.

Journal Article Semin Radiat Oncol · April 2014 Intraoperative radiation therapy (IORT) techniques allow for the delivery of high doses of radiation therapy while excluding part or all of the nearby dose-limiting sensitive structures. Therefore, the effective radiation dose is increased and local tumor ... Full text Link to item Cite

Incidence and prognostic impact of high-risk HPV tumor infection in cervical esophageal carcinoma

Journal Article Journal of Gastrointestinal Oncology · January 1, 2014 Background: Cervical esophageal carcinoma (CEC) is an uncommon malignancy. Limited data supports the use of definitive chemoradiotherapy (CRT) as primary treatment. Furthermore, the role of human papillomavirus (HPV) tumor infection in CEC remains unknown. ... Full text Cite

Reduced Volume Irradiation for Head-and-Neck Cancer of Unknown Primary (HNCUP)

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Early Results of a Randomized Trial to Identify an Optimal PTV in Stereotactic Radiosurgery of Brain Metastases

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

The role of local excision in invasive adenocarcinoma of the ampulla of Vater.

Journal Article J Gastrointest Oncol · March 2013 BACKGROUND: Ampulla of Vater carcinomas are rare malignancies that have been traditionally treated with radical surgical resection. Given the mortality associated with pancreaticoduodenectomy, some patients may benefit from local resection. A single-instit ... Full text Link to item Cite

Preoperative chemoradiotherapy for locally advanced gastric cancer.

Journal Article Radiat Oncol · January 4, 2013 BACKGROUND: To examine toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer. METHODS: Patients with gastroesophageal (GE) junction (Siewert type II and III) or gastric adenocarcinoma who underwent neoadjuv ... Full text Link to item Cite

Patterns of Failure for Stage I Ampulla of Vater Adenocarcinoma: A Single Institutional Experience

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2013 Full text Cite

Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy.

Journal Article Ann Surg Oncol · May 2012 BACKGROUND: Ampullary carcinoma is a rare malignancy. Despite radical resection, survival rates remain low with high rates of local failure. We performed a single-institution outcomes analysis to define the role of concurrent chemoradiotherapy (CRT) in add ... Full text Link to item Cite

A phase I/II study of capecitabine (Cape), oxaliplatin (Ox), panitumumab (Pmab), and external beam radiation therapy (RT) for patients with esophagogastric carcinoma (EC).

Journal Article J Clin Oncol · February 2012 68 Background: EC is commonly managed with concurrent chemoradiotherapy, with or without surgical resection. The optimal combination and dose of agents is the subject of continued investigation. This study examines chemotherapeutic agents with known effica ... Link to item Cite

A phase I/II study of capecitabine (Cape), oxaliplatin (Ox), panitumumab (Pmab), and external beam radiation therapy (RT) for patients with esophagogastric carcinoma (EC).

Conference Journal of Clinical Oncology · February 1, 2012 68 Background: EC is commonly managed with concurrent chemoradiotherapy, with or without surgical resection. The optimal combination and dose of agents is the subject of continued investigation. This study examines chemotherapeut ... Full text Cite

Preoperative single fraction partial breast radiotherapy for early-stage breast cancer.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2012 PURPOSE: Several recent series evaluating external beam accelerated partial breast irradiation (PBI) have reported adverse cosmetic outcomes, possibly related to large volumes of normal tissue receiving near-prescription doses. We hypothesized that deliver ... Full text Link to item Cite

Dosimetric Comparison Of Radiotherapy For Left Sided Breast Cancer: Breath-hold versus Free Breathing

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Twenty Year Experience with Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of the Oropharynx

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Role of radiation therapy in patients with resectable pancreatic cancer

Journal Article Oncology · August 12, 2011 The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. Although surgical resection remains the cornerstone of treatment, local and distant failure rates are ... Cite

Role of radiation therapy in patients with resectable pancreatic cancer.

Journal Article Oncology (Williston Park) · July 2011 The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. Although surgical resection remains the cornerstone of treatment, local and distant failure rates are ... Link to item Cite

In response to Drs. Kim and Shaitelman

Journal Article International Journal of Radiation Oncology Biology Physics · May 1, 2011 Full text Cite

Carcinoma of the ampulla of Vater: Patterns of failure after resection and benefit of adjuvant radiotherapy.

Journal Article Journal of Clinical Oncology · February 1, 2011 254 Background: Ampullary carcinoma is a rare malignancy. Despite radical resection, survival rates remain low with high rates of local failure. To define the role of radiation therapy and chemotherapy with surgery, we performed ... Full text Cite

Carcinoma of the ampulla of Vater: Patterns of failure after resection and benefit of adjuvant radiotherapy.

Journal Article J Clin Oncol · February 2011 254 Background: Ampullary carcinoma is a rare malignancy. Despite radical resection, survival rates remain low with high rates of local failure. To define the role of radiation therapy and chemotherapy with surgery, we performed a single institution analys ... Link to item Cite

Primary meningeal rhabdomyosarcoma.

Journal Article Sarcoma · 2011 Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical ... Full text Link to item Cite

The development of oncology treatment guidelines: an analysis of the National Guidelines Clearinghouse.

Journal Article Pract Radiat Oncol · 2011 PURPOSE: In the last 2 decades, guidelines have been developed to improve quality of patient care. A recent editorial of guideline development procedures suggested the process has significant limitations that affect their scientific validity.(1) This promp ... Full text Link to item Cite

Carcinoma of the Ampulla of Vater: Patterns of Failure after Resection and Possible Benefit of Adjuvant Radiotherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy.

Journal Article Cancer · April 15, 2010 BACKGROUND: With breast-conserving therapy (BCT) as the standard of care for patients with noninvasive and early stage invasive breast cancer, a small incidence of post-BCT angiosarcoma has emerged. The majority of therapeutic interventions have been unsuc ... Full text Link to item Cite

A Systematic Review of Oncology Treatment Guidelines: A Passing Grade with Government Agencies Receiving the Highest Marks

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

A survey off methods for analyzing clustered binary response data

Journal Article International Statistical Review · January 1, 1996 A comprehensive survey of regression-type models for clusters of correlated binary outcomes, including longitudinal data, is presented. In particular, we focus on models which can accommodate both between- and within-cluster categorical and continuous cova ... Full text Cite