Journal ArticleArch Pathol Lab Med · September 2018
CONTEXT: - Graft-versus-host disease of the gastrointestinal tract is a common complication of hematopoietic stem cell transplant associated with significant morbidity and mortality. Accurate diagnosis can be difficult and is a truly clinicopathologic ende ...
Full textLink to itemCite
Journal ArticleBiol Blood Marrow Transplant · April 2018
Gastrointestinal (GI) complications including graft-versus-host disease (GVHD) are a major cause of morbidity and mortality in allogenic stem transplant recipients. Although several studies have previously looked into the acute GI complications, fewer smal ...
Full textLink to itemCite
Journal ArticleDig Dis Sci · March 2016
BACKGROUND: Graft-versus-host disease (GVHD) complicates half of hematopoietic stem cell transplants (HCT), and the gastrointestinal tract is commonly affected. Endoscopic biopsies have a key role in the diagnosis. The optimal procedure(s) to perform and s ...
Full textLink to itemCite
Journal ArticleLeuk Lymphoma · 2015
Idelalisib is a first-in-class selective, oral, phosphatidylinositol 3-kinase delta (PI3Kδ) inhibitor approved for the treatment of several types of blood cancer. Idelalisib has demonstrated significant efficacy and a tolerable safety profile in clinical t ...
Full textLink to itemCite
Journal ArticleJOP · September 10, 2012
CONTEXT: Animal studies have demonstrated a role for substance P binding to neurokinin-1 receptor in the pathogenesis of acute pancreatitis. OBJECTIVE: Our aim was to assess the efficacy of a neurokinin-1 receptor antagonist (aprepitant) at preventing post ...
Full textLink to itemCite
Journal Article · December 1, 2010
In 1884 Gallard wrote the first description of a patient with a Dieulafoy's lesion [1]. The lesion's name, however, comes from Paul Georges Dieulafoy (1839-1911), a professor of pathology at the Faculty of Medicine in Paris. In 1898 Dieulafoy described sev ...
Full textCite
Journal ArticleOncologist · 2010
INTRODUCTION: Bevacizumab is increasingly being tested with neoadjuvant regimens in patients with localized cancer, but its effects on metastasis and survival remain unknown. This study examines the long-term outcome of clinical stage II/III rectal cancer ...
Full textLink to itemCite
Journal ArticleOncologist · 2010
We explored plasma and urinary concentrations of two members of the vascular endothelial growth factor (VEGF) family and their receptors as potential response and toxicity biomarkers of bevacizumab with neoadjuvant chemoradiation in patients with localized ...
Full textLink to itemCite
Journal ArticleCancer Res · October 15, 2009
Clinical studies converge on the observation that circulating cytokines are elevated in most cancer patients by anti-vascular endothelial growth factor (VEGF) therapy. However, the source of these molecules and their relevance in tumor escape remain unknow ...
Full textLink to itemCite
Journal ArticleJ Clin Oncol · June 20, 2009
PURPOSE: To assess the safety and efficacy of neoadjuvant bevacizumab with standard chemoradiotherapy in locally advanced rectal cancer and explore biomarkers for response. PATIENTS AND METHODS: In a phase I/II study, 32 patients received four cycles of th ...
Full textLink to itemCite
Journal ArticleClin Immunol · September 2008
Inflammatory bowel disease (IBD) is a T cell driven inflammatory condition of the gut. Following solid organ transplantation (SOT), de novo IBD has been reported despite anti-T cell therapy for the prevention of organ rejection. This paradox is illustrated ...
Full textLink to itemCite
Journal ArticleJ Clin Gastroenterol · August 2008
GOALS: We aimed to evaluate the ability of capsule endoscopy (CE) to detect small intestine (SI) lesions, especially SI varices, in patients with intrahepatic cirrhosis, portal hypertension (PHTN), and chronic anemia. BACKGROUND: Gastroesophageal variceal ...
Full textLink to itemCite
Journal ArticleNat Clin Pract Oncol · May 2007
BACKGROUND: Localized rectal cancer responds well to 5-fluorouracil and radiation-based regimens. A phase I-II trial is currently testing the efficacy of adding bevacizumab, a VEGF-specific antibody, to standard chemoradiotherapy. The case presented here i ...
Full textLink to itemCite
Journal ArticleGastroenterology · April 1997
BACKGROUND & AIMS: The efficacy of mesalamine for the maintenance of remission in patients with Crohn's disease is controversial. The aim of this study was to conduct a double-blind, placebo-controlled study of mesalamine (750 mg four times a day for 48 we ...
Full textLink to itemCite
Journal ArticleDigestion · 1991
Featured Publication
The aim of this study was to examine the effects of varying doses of pirenzepine, a selective muscarinic subtype M1 antagonist, on the prevention of acute gastric mucosal lesions in male Sprague-Dawley rats subjected to spinal cord section at the C7 level. ...
Full textLink to itemCite
Journal ArticleProblems in General Surgery · January 1, 1987
Colorectal carcinoma fulfills most of the criteria for disease screening. It occurs frequently in the general population, early detection results in longer survival, and premalignant polyps can often be detected and eradicated. Occult blood testing is safe ...
Cite
Journal ArticleCan J Surg · March 1986
Featured Publication
It is common clinical practice to test stools for occult blood and to rely heavily upon the result in deciding whether to investigate further. Because the accuracy of such testing has been questioned, a study was conducted to estimate the sensitivity of th ...
Link to itemCite
Journal ArticleAm J Gastroenterol · February 1986
Featured Publication
To assess the efficacy of cimetidine versus Mylanta II in the prevention of stress erosions, 44 patients at risk were randomized to receive cimetidine 300 mg/6 h intravenously to a maximum of 400 mg/4 h; or Mylanta II 30 ml/h through a nasogastric tube to ...
Link to itemCite
Journal ArticleCancer · March 1978
By contract with the National Cancer Institute, the accuracy of diagnostic techniques was assessed in 184 patients suspected of having pancreas cancer. Of 138 patients who were operated upon, 89 were found to have pancreas duct cancer, 30 had cancer of a d ...
Full textLink to itemCite