Scholars@Duke
Michael Paul Carboni

Michael Paul Carboni

Associate Professor of Pediatrics
Pediatrics, Cardiology
michael.carboni@duke.edu
Box 3090 Med Ctr, Durham, NC
Dept of Pediatrics, Durham, NC

Selected Publications

School age and adolescent heart failure following the Norwood procedure.

Journal Article J Heart Lung Transplant · March 2024 BACKGROUND: Heart failure results in significant morbidity and mortality for young children with hypoplastic left heart syndrome (HLHS) following the Norwood procedure. The trajectory in later childhood is not well described. METHODS: We studied the outcom ... Full text Link to item Cite

Partial Heart Transplant in a Neonate With Irreparable Truncal Valve Dysfunction.

Journal Article JAMA · January 2, 2024 IMPORTANCE: The treatment of neonates with irreparable heart valve dysfunction remains an unsolved problem because there are no heart valve implants that grow. Therefore, neonates with heart valve implants are committed to recurrent implant exchanges until ... Full text Link to item Cite

Racial and socioeconomic disparities in pediatric heart transplant outcomes in the era of anti-thymocyte globulin induction.

Conference J Heart Lung Transplant · December 2022 BACKGROUND: Black race is associated with worse outcomes across solid organ transplantation. Augmenting immunosuppression through antithymocyte globulin (ATG) induction may mitigate organ rejection and graft loss. We investigated whether racial and socioec ... Full text Link to item Cite

Relationship of ventricular assist device support duration with pediatric heart transplant outcomes.

Journal Article J Heart Lung Transplant · January 2022 BACKGROUND: There is wide variability in the timing of heart transplant (HTx) after pediatric VAD implant. While some centers wait months before listing for HTx, others accept donor heart offers within days of VAD surgery. We sought to determine if HTx wit ... Full text Open Access Link to item Cite

Practice variation in the diagnosis of acute rejection among pediatric heart transplant centers: An analysis of the pediatric heart transplant society (PHTS) registry.

Journal Article J Heart Lung Transplant · December 2021 BACKGROUND: Freedom from rejection in pediatric heart transplant recipients is highly variable across centers. This study aimed to assess the center variation in methods used to diagnose rejection in the first-year post-transplant and determine the impact ... Full text Open Access Link to item Cite

ATP1A3-Encoded Sodium-Potassium ATPase Subunit Alpha 3 D801N Variant Is Associated With Shortened QT Interval and Predisposition to Ventricular Fibrillation Preceded by Bradycardia.

Journal Article J Am Heart Assoc · September 7, 2021 Background Pathogenic variation in the ATP1A3-encoded sodium-potassium ATPase, ATP1A3, is responsible for alternating hemiplegia of childhood (AHC). Although these patients experience a high rate of sudden unexpected death in epilepsy, the pathophysiologic ... Full text Open Access Link to item Cite

Cardiac phenotype in ATP1A3-related syndromes: A multicenter cohort study.

Journal Article Neurology · November 24, 2020 OBJECTIVE: To define the risks and consequences of cardiac abnormalities in ATP1A3-related syndromes. METHODS: Patients meeting clinical diagnostic criteria for rapid-onset dystonia-parkinsonism (RDP), alternating hemiplegia of childhood (AHC), and cerebel ... Full text Open Access Link to item Cite

Abstract 13291: Impact of VAD Support Duration on Pediatric Heart Transplant Outcomes

Conference Circulation · November 17, 2020 Introduction: There is wide variability in the timing of heart transplant (HT) listing and consideration of organ offers after ventricular assist device (VAD) implant in children. While some centers w ... Full text Cite

New-onset diabetes after pediatric heart transplantation: A review of the Pediatric Heart Transplant Study.

Journal Article Pediatr Transplant · August 2019 NDT is a well-defined complication after solid organ transplantation. Little has been published describing the incidence, risk factors, and effect on outcome after pediatric heart transplantation. We performed a retrospective evaluation of pediatric patien ... Full text Link to item Cite

Variability in radiation dose and image quality: A comparison across fluoroscopy-system vendors, generations of equipment and institutions.

Journal Article Catheter Cardiovasc Interv · December 1, 2018 OBJECTIVES: To evaluate differences in radiation dose and image quality across institutions, fluoroscope vendors and generations of fluoroscopes for pediatric cardiac catheterization. BACKGROUND: Increased recognition of the potentially harmful effects of ... Full text Link to item Cite

Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial.

Journal Article JAMA Cardiol · July 1, 2017 IMPORTANCE: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal genetic arrhythmia syndrome characterized by polymorphic ventricular tachycardia with physical or emotional stress, for which current therapy with β-blockers i ... Full text Link to item Cite

Abstract 12670: Variability in Radiation Dose and Image Quality: A Comparison Across Fluoroscopy-system Vendors and Generations of Equipment.

Journal Article Circulation · November 11, 2016 INTRODUCTION: Increased recognition of the potentially harmful effects of ionizing radiation has spurred technological advances to reduce exposure during fluoroscopy. However there is currently little understanding of the dose-image quality (IQ) relationsh ... Link to item Cite

Quinidine in the treatment of KCNT1-positive epilepsies.

Journal Article Ann Neurol · December 2015 We report 2 patients with drug-resistant epilepsy caused by KCNT1 mutations who were treated with quinidine. Both mutations manifested gain of function in vitro, showing increased current that was reduced by quinidine. One, who had epilepsy of infancy with ... Full text Link to item Cite

Fontan-associated protein-losing enteropathy and heart transplant: A Pediatric Heart Transplant Study analysis.

Journal Article J Heart Lung Transplant · September 2015 BACKGROUND: Post-Fontan protein-losing enteropathy (PLE) is associated with significant morbidity and mortality. Although heart transplantation (HTx) can be curative, PLE may increase the risk of morbidity before and after HTx. This study analyzed the infl ... Full text Link to item Cite

Outcomes after percutaneous coronary artery revascularization procedures for cardiac allograft vasculopathy in pediatric heart transplant recipients: A multi-institutional study.

Conference J Heart Lung Transplant · September 2015 BACKGROUND: Cardiac allograft vasculopathy is an important cause of long-term graft loss. In adults, percutaneous revascularization procedures (PRPs) have variable success with high restenosis rates and little impact on graft survival. Limited data exist i ... Full text Open Access Link to item Cite

Improved Detection of Cardiac Allograft Vasculopathy: A Multi-Institutional Analysis of Functional Parameters in Pediatric Heart Transplant Recipients.

Journal Article J Am Coll Cardiol · August 4, 2015 BACKGROUND: Recent guidelines recommend assessment of systolic function and filling pressures to augment angiographic grading of cardiac allograft vasculopathy (CAV); however, no data exist on the utility of these guidelines. OBJECTIVES: The aims of this s ... Full text Link to item Cite

Management of pediatric tachyarrhythmias on mechanical support.

Journal Article Circ Arrhythm Electrophysiol · August 2014 BACKGROUND: Pediatric patients with persistent arrhythmias may require mechanical cardiopulmonary support. We sought to classify the population, spectrum, and success of current treatment strategies. METHODS AND RESULTS: A multicenter retrospective chart r ... Full text Link to item Cite

Laser lead extraction in congenital heart disease: a case-controlled study.

Journal Article Pacing Clin Electrophysiol · March 2013 INTRODUCTION: Patients with congenital heart disease (CHD) and implanted cardiac rhythm management devices have a high rate of endocardial lead issues requiring lead extraction. Laser lead extraction (LLE) is a promising modality for lead management though ... Full text Link to item Cite

82-P

Conference Human Immunology · October 2012 Full text Cite

7-OR

Conference Human Immunology · October 2012 Full text Cite

The ventricular volume variability study of the Pediatric Heart Network: study design and impact of beat averaging and variable type on the reproducibility of echocardiographic measurements in children with chronic dilated cardiomyopathy.

Journal Article J Am Soc Echocardiogr · August 2012 BACKGROUND: Clinical trials often rely on echocardiographic measures of left ventricular size and function as surrogate end points. However, the quantitative impact of factors that affect the reproducibility of these measures is unknown. To address this is ... Full text Link to item Cite

Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay.

Journal Article Circulation · January 3, 2012 BACKGROUND: Brugada syndrome is a potentially serious channelopathy that usually presents in adulthood and has only rarely been described in infancy. In the absence of metabolic or structural cardiac disease, rapid ventricular tachycardia (>200 bpm) and pr ... Full text Link to item Cite

Preoperative diagnosis of long QT syndrome in an infant with tetralogy of Fallot.

Journal Article Pediatr Cardiol · August 2011 Long QT syndrome is a well-described entity in infants. Its presentation in the context of congenital heart disease is rare and is almost exclusively diagnosed postoperatively. For patients undergoing surgical intervention, preoperative knowledge of the di ... Full text Link to item Cite

Two children with "dropped head" syndrome due to lamin A/C mutations.

Journal Article Muscle Nerve · November 2010 LMNA-related congenital muscular dystrophy (L-CMD) is a recently described disorder characterized by infantile-onset myopathy due to mutations in the lamin A/C (LMNA) gene. We report the genetic and clinical characteristics of two unrelated L-CMD patients. ... Full text Link to item Cite

Arrhythmias in children having a single left superior vena cava and minimal structural heart disease.

Journal Article J Cardiovasc Electrophysiol · February 2009 Featured Publication BACKGROUND: The presence of a single left superior vena cava in the absence of complex congenital heart disease is uncommon, and, in the absence of hemodynamic consequences, it would not be expected to result in cardiovascular signs or symptoms. Single cas ... Full text Link to item Cite

Pediatric Arrhythmias

Journal Article · December 1, 2006 Full text Cite

Ambulatory electrocardiogram analysis in infants treated with recombinant human acid alpha-glucosidase enzyme replacement therapy for Pompe disease.

Journal Article Genet Med · May 2006 Featured Publication PURPOSE: Infantile Pompe disease is caused by deficiency of lysosomal acid alpha-glucosidase. Trials with recombinant human acid alpha-glucosidase enzyme replacement therapy (ERT) show a decrease in left ventricular mass and improved function. We evaluated ... Full text Link to item Cite

Transthoracic percutaneous access for electroanatomic mapping and catheter ablation of atrial tachycardia in patients with a lateral tunnel Fontan.

Journal Article Heart Rhythm · January 2006 Featured Publication BACKGROUND: The incidence of atrial tachycardia following Fontan surgery is high, but access to the pulmonary venous atrium, a frequent site of arrhythmia origin, is limited. OBJECTIVES: The purpose of this study is to report our results with a novel trans ... Full text Link to item Cite

Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue.

Journal Article J Membr Biol · September 2005 Featured Publication Voltage- and/or conformation-dependent association and dissociation of local anesthetic-class drugs from a putative receptor site in domain IV S6 of the sodium channel and slow conformation transitions of the drug-associated channel have been proposed as m ... Full text Link to item Cite

Ventricular arrhythmia in the X-linked cardiomyopathy Barth syndrome.

Journal Article Pediatr Cardiol · 2005 Featured Publication Barth syndrome is an X-linked disorder characterized by dilated cardiomyopathy, cyclic neutropenia, skeletal myopathy, abnormal mitochondria, and growth deficiency. The primary defect is a mutation in the TAZ gene on the X chromosome at Xq28, resulting in ... Full text Link to item Cite

Endocardial atrial pacing lead implantation and midterm follow-up in young patients with sinus node dysfunction after the fontan procedure.

Journal Article Pacing Clin Electrophysiol · July 2004 Featured Publication The purpose of the study was to investigate the results of endocardial lead implantation, lead performance, and follow-up in young patients after the Fontan procedure. A retrospective study was conducted with patients who had endocardial atrial pacing for ... Full text Link to item Cite

Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation.

Journal Article J Clin Invest · October 2002 Featured Publication The function of the 12 positive charges in the 53-residue III/IV interdomain linker of the cardiac Na(+) channel is unclear. We have identified a four-generation family, including 17 gene carriers with long QT syndrome, Brugada syndrome, and conduction sys ... Full text Link to item Cite

Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells.

Journal Article Biophys J · December 2000 Featured Publication The role of inactivation as a central mechanism in blockade of the cardiac Na(+) channel by antiarrhythmic drugs remains uncertain. We have used whole-cell and single channel recordings to examine the block of wild-type and inactivation-deficient mutant ca ... Full text Link to item Cite

Radiofrequency catheter ablation of supraventricular tachycardia substrates after mustard and senning operations for d-transposition of the great arteries.

Journal Article J Am Coll Cardiol · February 2000 Featured Publication OBJECTIVES: The purpose of this study was to determine the efficacy and risks of radiofrequency ablation of various forms of supraventricular tachycardia after Mustard and Senning operations for d-transposition of the great arteries. BACKGROUND: In this pa ... Full text Link to item Cite

Chest pain in the adolescent and young adult.

Journal Article Cardiol Rev · 2000 Featured Publication Pediatric cardiologists and cardiologists who examine adults frequently receive referrals of adolescents and young adults with chest pain. Chest pain in this age group is most likely noncardiac in origin, which often creates a diagnostic dilemma for the co ... Full text Link to item Cite

Ductus arteriosus in premature infants beyond the second week of life.

Journal Article Pediatr Cardiol · 1997 Featured Publication Persistent patency of the ductus arteriosus (PDA), common in premature infants, is associated with severe respiratory distress. The likelihood and significance of finding PDA in premature infants beyond the second week of life is unknown. We retrospectivel ... Full text Link to item Cite