Scholars@Duke
Michael Evan Lidsky

Michael Evan Lidsky

Associate Professor of Surgery
Surgical Oncology
michael.lidsky@duke.edu
Dept of Surgery, Box 3966, Durham, NC 27710

Selected Publications

Perioperative and Oncologic Outcomes of Hepatic Arterial Infusion (HAI) Pump Chemotherapy for Patients with Unresectable Colorectal Liver Metastases at an Expanding HAI Program.

Conference Ann Surg Oncol · November 20, 2024 BACKGROUND: Hepatic arterial infusion (HAI) is an established treatment for patients with unresectable colorectal liver metastases (uCRLM). Until recently, HAI was only performed at a limited number of centers. We previously reported early outcomes suggest ... Full text Link to item Cite

Market Factors, Not Quality, Influence Reimbursement for Pancreaticoduodenectomy in an Era of Price Transparency.

Journal Article Ann Surg Oncol · November 2024 BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) price transparency rule tries to facilitate cost-conscious decision-making. For surgical services, such as pancreaticoduodenectomy (PD), factors mediating transparency and real-world reimburs ... Full text Link to item Cite

Development and internal validation of individualized prediction models of overall survival and 6-month mortality among patients with synchronous early-onset colorectal liver metastases.

Journal Article HPB (Oxford) · November 2024 BACKGROUND: Early-onset colorectal cancer with synchronous liver metastasis (EO-CRLM) is a growing concern with a grim prognosis. METHODS: EO-CRLM patients were identified from the National Cancer Database. Random survival forest model and random forest (R ... Full text Link to item Cite

Evolution of Initial Treatment for Desmoid Tumors.

Journal Article Ann Surg Oncol · November 2024 INTRODUCTION: Desmoid tumors (DTs) are rare, fibroblastic cell proliferations that can exhibit locally aggressive behavior but lack metastatic potential. Initial management has traditionally involved upfront resection; however, contemporary guidelines and ... Full text Link to item Cite

Survival Outcomes and Genetic Characteristics of Resected Pancreatic Acinar Cell Carcinoma.

Journal Article Annals of surgical oncology · November 2024 BackgroundPancreatic acinar cell carcinoma (pACC) is a rare neoplasm of the exocrine pancreas. There is a dearth of information about tumor characteristics and patient outcomes. This study describes the clinical characteristics, genetic alteration ... Full text Cite

Genome-Derived Ampullary Adenocarcinoma Classifier and Postresection Prognostication.

Journal Article JAMA Surg · September 11, 2024 IMPORTANCE: Ampullary adenocarcinoma (AA) is characterized by clinical and genomic heterogeneity. A previously developed genomic classifier defined biologically distinct phenotypes with greater accuracy than standard histologic classification. External val ... Full text Link to item Cite

A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.

Journal Article Lancet Digit Health · July 2024 BACKGROUND: Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery to estimate the risk of postoperative pulmonary compl ... Full text Link to item Cite

Contemporary trends and outcomes after liver transplantation and resection for intrahepatic cholangiocarcinoma.

Journal Article J Gastrointest Surg · May 2024 BACKGROUND: Liver transplantation (LT) has been shown to be superior to resection in highly selected patients with perihilar cholangiocarcinoma (CCA), yet has traditionally been contraindicated for intrahepatic CCA (iCCA). Herein, we aimed to examine conte ... Full text Link to item Cite

Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer.

Journal Article HPB (Oxford) · April 2024 BACKGROUND: Radical cholecystectomy is recommended for T1B and greater gallbladder cancer, however, there are conflicting reports on the utility of extended resection for T1B disease. Herein, we characterize outcomes following simple and radical cholecyste ... Full text Link to item Cite

Defining the learning curve for robotic pancreaticoduodenectomy for a single surgeon following experience with laparoscopic pancreaticoduodenectomy.

Journal Article J Robot Surg · March 16, 2024 Robotic pancreaticoduodenectomy (RPD) has a learning curve of approximately 30-250 cases to reach proficiency. The learning curve for laparoscopic pancreaticoduodenectomy (LPD) at Duke University was previously defined as 50 cases. This study describes the ... Full text Link to item Cite

Concordance in Oncogenic Alterations Between the Primary Tumor and Advanced Disease: Insights Into the Heterogeneity of Intrahepatic Cholangiocarcinoma.

Journal Article JCO Precis Oncol · February 2024 PURPOSE: Intrahepatic cholangiocarcinoma (ICCA) is characterized by significant phenotypic and clinical heterogeneities and poor response to systemic therapy, potentially related to underlying heterogeneity in oncogenic alterations. We aimed to characteriz ... Full text Link to item Cite

Impact of primary tumor resection and metastasectomy among gastroentero-pancreatic neuroendocrine tumors with liver metastases only on survival.

Journal Article HPB (Oxford) · January 2024 BACKGROUND: Despite recommendations for primary tumor resection (PTR) with or without liver resection (LR) in the patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and isolated liver metastases, there are conflicting data for their impa ... Full text Open Access Link to item Cite

International Hepato-Pancreato-Billiary Association (IHPBA) registry study on COVID-19 infections in HPB surgery patients.

Journal Article HPB (Oxford) · January 2024 BACKGROUND: In response to the pandemic, the International Hepato-Pancreato-Biliary Association (IHPBA) developed the IHPBA-COVID Registry to capture data on HPB surgery outcomes in COVID-positive patients prior to mass vaccination programs. The aim was to ... Full text Link to item Cite

Tumor size and survival in intrahepatic cholangiocarcinoma treated with surgical resection or ablation.

Journal Article J Surg Oncol · December 2023 OBJECTIVES: We performed a retrospective analysis within a national cancer registry on outcomes following resection or ablation for intrahepatic cholangiocarcinoma (iCCA). METHODS: The National Cancer Database was queried for patients with clinical stage I ... Full text Link to item Cite

Current Practices in Hepatic Artery Infusion (HAI) Chemotherapy: An International Survey of the HAI Consortium Research Network.

Journal Article Ann Surg Oncol · November 2023 BACKGROUND: An increasing number of hepatic artery infusion (HAI) programs have been established worldwide. Practice patterns for this complex therapy across these programs have not been reported. This survey aimed to identify current practice patterns in ... Full text Link to item Cite

Comparing Survival After Resection, Ablation, and Radiation in Small Intrahepatic Cholangiocarcinoma.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Hepatectomy is the cornerstone of curative-intent treatment for intrahepatic cholangiocarcinoma (ICC). However, in patients unable to be resected, data comparing efficacy of alternatives including thermal ablation and radiation therapy (RT) rem ... Full text Open Access Link to item Cite

Impact of Tumor Size and Management on Survival in Small Gastric Gastrointestinal Stromal Tumors.

Journal Article J Gastrointest Surg · October 2023 BACKGROUND: Society guidelines remain inconsistent on the role of endoscopic and radiographic surveillance as an alternative to surgical resection of small gastric gastrointestinal stromal tumors (GISTs). Herein, we aimed to assess survival among patients ... Full text Link to item Cite

Impact of surgical approach on short- and long-term outcomes in gastroenteropancreatic neuroendocrine carcinomas.

Journal Article HPB (Oxford) · October 2023 BACKGROUND: Literature is lacking on the impact of advancements in minimally invasive surgery (MIS) on outcomes for patients with gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs). Herein, we compared perioperative and oncologic outcomes among pa ... Full text Open Access Link to item Cite

Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers.

Journal Article Ann Surg Oncol · August 2023 BACKGROUND: Resection remains the cornerstone of curative-intent treatment for biliary tract cancers (BTCs). However, recent randomized data also support a role for adjuvant chemotherapy (AC). This study aimed to characterize trends in the use of AC and su ... Full text Link to item Cite

Hepatic artery infusion for unresectable colorectal cancer liver metastases: Palliation and conversion.

Journal Article Surgery · August 2023 Patients with unresectable colorectal liver metastases are commonly treated with systemic chemotherapy to convert their disease to an operable state. Unfortunately, many patients remain unresectable after first-line chemotherapy and resort to second- and t ... Full text Link to item Cite

Primary tumor resection improves survival of gastrointestinal neuroendocrine carcinoma patients with nonresected liver metastases.

Journal Article J Surg Oncol · May 2023 BACKGROUND: The role of primary tumor resection (PTR) in the survival of gastrointestinal neuroendocrine carcinoma (GI-NEC) patients with liver metastases only remains poorly defined. Therefore, we investigated the impact of PTR on the survival of GI-NEC p ... Full text Open Access Link to item Cite

Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians.

Journal Article CA Cancer J Clin · March 2023 Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor and remains a fatal malignancy in the majority of patients. Approximately 20%-30% of patients are eligible for resection, which is considered the only potentially curative ... Full text Link to item Cite

Colorectal Cancer Liver Metastases: Multimodal Therapy.

Journal Article Surg Oncol Clin N Am · January 2023 Despite a steady decline in incidence and mortality rates, colorectal cancer (CRC) remains the second most common cancer diagnosis in women and the third most common in men worldwide. Notably, the liver is recognized as the most common site of CRC metastas ... Full text Open Access Link to item Cite

Evolution in Management of Upfront Treatment For Desmoid Tumors

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

Impact of Tumor Size and Management on Survival in Gastric GIST

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

Considerations and barriers to starting a new HAI pump program: an international survey of the HAI Consortium Research Network.

Journal Article HPB (Oxford) · December 2022 BACKGROUND: Widespread implementation of HAI pump chemotherapy has been limited by logistic and feasibility concerns. Recent studies demonstrating excellent outcomes have fueled renewed enthusiasm and multiple new programs have emerged. This survey aims to ... Full text Link to item Cite

Hepatic Artery Infusion Pumps: A Surgical Toolkit for Intraoperative Decision-Making and Management of Hepatic Artery Infusion-Specific Complications.

Journal Article Ann Surg · December 1, 2022 BACKGROUND: Hepatic artery infusion (HAI) is a liver-directed therapy that delivers high-dose chemotherapy to the liver through the hepatic arterial system for colorectal liver metastases and intrahepatic cholangiocarcinoma. Utilization of HAI is rapidly e ... Full text Link to item Cite

Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies.

Journal Article NPJ Precis Oncol · October 23, 2022 Intrahepatic cholangiocarcinoma (ICC) remains a deadly malignancy lacking systemic therapies for advanced disease. Recent advancements include selective FGFR1-3 inhibitors for the 15% of ICC patients harboring fusions, although survival is limited by poor ... Full text Link to item Cite

Surgical resection is associated with improved long-term survival of patients with resectable pancreatic head cancer compared to multiagent chemotherapy.

Journal Article HPB (Oxford) · July 2022 BACKGROUND: Standard of care for resectable pancreatic cancer is a combination of surgical resection (SR) and multiagent chemotherapy (MCT). We aim to determine whether SR or MCT is associated with superior survival for patients receiving only single-modal ... Full text Link to item Cite

Combined Primary Resection with Hepatic Artery Infusion Pump Implantation Is Safe for Unresectable Colorectal Liver Metastases.

Journal Article J Gastrointest Surg · April 2022 BACKGROUND: Colorectal liver metastases (CRLM) are the most common cause of disease-specific mortality in patients with colorectal cancer. Hepatic artery infusion (HAI) combined with systemic chemotherapy improves survival for these patients. The safety of ... Full text Link to item Cite

Perioperative and oncologic outcomes of hepatic artery infusion pump therapy at an expanding HAI program.

Conference Journal of Clinical Oncology · February 1, 2022 120 Background: Hepatic artery infusion (HAI) is a liver directed therapy to treat unresectable or resected colorectal liver metastases (CRLM) and unresectable intrahepatic cholangiocarcinoma (ICC). Historically, HAI has only bee ... Full text Cite

Empiric nasogastric decompression after pancreaticoduodenectomy is not necessary.

Journal Article HPB (Oxford) · December 2021 BACKGROUND: The aim of the present study was to evaluate the impact of routine NGT decompression after PD on postoperative outcomes in the era of an enhanced recovery after surgery (ERAS) protocol. MATERIALS AND METHODS: A retrospective review of all patie ... Full text Link to item Cite

Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.

Journal Article Br J Surg · December 1, 2021 BACKGROUND: This study aimed to determine the impact of pulmonary complications on death after surgery both before and during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. METHODS: This was a patient-level, comparative analysis ... Full text Link to item Cite

Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.

Journal Article Lancet Oncol · November 2021 BACKGROUND: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during ... Full text Link to item Cite

Validation of the 8th Edition American Joint Commission on Cancer (AJCC) Gallbladder Cancer Staging System: Prognostic Discrimination and Identification of Key Predictive Factors.

Journal Article Cancers (Basel) · February 1, 2021 The scope of our study was to compare the predictive ability of American Joint Committee on Cancer (AJCC) 7th and 8th edition in gallbladder carcinoma (GBC) patients, investigate the effect of AJCC 8th nodal status on the survival, and identify risk factor ... Full text Link to item Cite

Hepatic Arterial Infusion Pumps: What the Radiologist Needs to Know.

Journal Article Radiographics · 2021 Hepatic arterial infusion (HAI) entails the surgical implantation of a subcutaneous pump to deliver chemotherapeutic agents directly to the liver in the setting of primary or secondary liver cancer. The purpose of HAI chemotherapy is to maximize hepatic dr ... Full text Link to item Cite

Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.

Journal Article The British journal of surgery · January 2021 BackgroundSurgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective can ... Full text Open Access Cite

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Journal Article J Clin Oncol · January 1, 2021 PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with ... Full text Link to item Cite

Implementation of a Hepatic Artery Infusion Program: Initial Patient Selection and Perioperative Outcomes of Concurrent Hepatic Artery Infusion and Systemic Chemotherapy for Colorectal Liver Metastases.

Journal Article Ann Surg Oncol · December 2020 BACKGROUND: Hepatic artery infusion (HAI) combined with systemic chemotherapy is a treatment strategy for patients with unresectable liver-only or liver-dominant colorectal liver metastases (CRLM). Although HAI has previously been performed in only a few c ... Full text Link to item Cite

Short-Term Risk of Performing Concurrent Procedures with Hepatic Artery Infusion Pump Placement.

Journal Article Ann Surg Oncol · December 2020 BACKGROUND: Hepatic artery infusion pump (HAIP) chemotherapy is an advanced cancer therapy for primary and secondary hepatic malignancies. The risk of concurrent hepatic and/or colorectal operations with HAIP placement is unknown. Our objective was to char ... Full text Link to item Cite

Delaying surgery for patients with a previous SARS-CoV-2 infection.

Journal Article The British journal of surgery · November 2020 Full text Cite

Prevalence of Musculoskeletal Symptoms and Ergonomics Among Plastic Surgery Residents: Results of a National Survey and Analysis of Contributing Factors.

Journal Article Ann Plast Surg · September 2020 BACKGROUND: Musculoskeletal symptoms and injuries among surgeons are underestimated but are increasingly recognized to constitute a major problem. However, it has not been established when symptoms start and what factors contribute to the development of sy ... Full text Link to item Cite

CD226 Expression is Associated with Increased Survival in Pancreatic Cancer

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2020 Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Hospital Volume Threshold for the Treatment of Retroperitoneal Sarcoma.

Journal Article Anticancer Res · April 2019 BACKGROUND: Retroperitoneal sarcomas (RPS) are rare, histologically heterogeneous, and anatomically complex tumors. National Comprehensive Cancer Network guidelines recommend evaluation and management by multidisciplinary teams with experience in sarcoma. ... Full text Link to item Cite

Surgical management of hilar cholangiocarcinoma at Memorial Sloan Kettering Cancer Center.

Journal Article Ann Gastroenterol Surg · July 2018 Hilar cholangiocarcinoma, which represents approximately 60% of biliary tract malignancies, is increasing in incidence and presents an ongoing challenge for patients and hepatobiliary surgeons. Although the majority of patients present with advanced diseas ... Full text Link to item Cite

Association of Integrated Care Coordination With Postsurgical Outcomes in High-Risk Older Adults: The Perioperative Optimization of Senior Health (POSH) Initiative.

Journal Article JAMA Surg · May 1, 2018 IMPORTANCE: Older adults undergoing elective surgery experience higher rates of preventable postoperative complications than younger patients. OBJECTIVE: To assess clinical outcomes for older adults undergoing elective abdominal surgery via a collaborative ... Full text Link to item Cite

Going the Extra Mile: Improved Survival for Pancreatic Cancer Patients Traveling to High-volume Centers.

Conference Ann Surg · August 2017 OBJECTIVE: This study compares outcomes following pancreaticoduodenectomy (PD) for patients treated at local, low-volume centers and those traveling to high-volume centers. BACKGROUND: Although outcomes for PD are superior at high-volume institutions, not ... Full text Link to item Cite

Subtotal cholecystectomy for the hostile gallbladder: failure to control the cystic duct results in significant morbidity.

Journal Article HPB (Oxford) · June 2017 BACKGROUND: Outcomes following the inability to control the cystic duct due to a hostile triangle of Calot during cholecystectomy remain unknown. The purpose of this study was to analyze the safety and efficacy of subtotal cholecystectomy, with attention t ... Full text Link to item Cite

An outlook on precision surgery.

Journal Article Eur J Surg Oncol · May 2017 Full text Link to item Cite

Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma.

Journal Article Ann Surg · February 2015 OBJECTIVE: We investigate the mechanism through which N-cadherin disruption alters the effectiveness of regional chemotherapy for locally advanced melanoma. BACKGROUND: N-cadherin antagonism during regional chemotherapy has demonstrated variable treatment ... Full text Link to item Cite

Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells.

Journal Article J Biol Chem · October 3, 2014 Although targeting the V600E activating mutation in the BRAF gene, the most common genetic abnormality in melanoma, has shown clinical efficacy in melanoma patients, response is, invariably, short lived. To better understand mechanisms underlying this acqu ... Full text Link to item Cite

Multi-institutional analysis of recurrence and survival after hepatectomy for fibrolamellar carcinoma.

Journal Article J Surg Oncol · September 2014 BACKGROUND AND OBJECTIVES: Fibrolamellar carcinoma (FLC) presents in young, otherwise-healthy individuals. This study examined recurrence and survival characteristics after surgical resection for FLC by utilizing an international multi-institutional databa ... Full text Link to item Cite

Emerging role of contrast-enhanced MRI in diagnosing vascular malformations.

Journal Article Future Cardiol · July 2014 Vascular malformations comprise a diverse and rare group of lesions which generally pose a formidable treatment challenge. Requisite for optimal surgical planning are imaging modalities capable of delineating involved anatomy and malformation flow characte ... Full text Link to item Cite

Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma.

Journal Article Ann Surg Oncol · May 2014 BACKGROUND: There is increasing evidence that tumor hypoxia plays a significant role in the chemoresistance of melanoma, but to our knowledge, real-time tumor oxygenation during isolated limb infusion (ILI) has not been studied. We sought to demonstrate th ... Full text Link to item Cite

Does the presence of coronary artery disease impact perioperative outcomes following partial hepatectomy?

Journal Article J Gastrointest Surg · April 2014 INTRODUCTION: Coronary artery disease (CAD) is often considered a contraindication to hepatectomy despite a lack of data to support this practice. The purpose of this study is to evaluate the impact of CAD on postoperative outcomes in patients undergoing h ... Full text Link to item Cite

Hepatic resection for hepatocellular carcinoma: do contemporary morbidity and mortality rates demand a transition to ablation as first-line treatment?

Journal Article J Am Coll Surg · April 2014 BACKGROUND: Despite the rising incidence of hepatocellular carcinoma (HCC), challenges and controversy persist in optimizing treatment. As recent randomized trials suggest that ablation can have oncologic equivalence compared with resection for early HCC, ... Full text Link to item Cite

SRC family kinase inhibition as a novel strategy to augment melphalan-based regional chemotherapy of advanced extremity melanoma.

Journal Article Ann Surg Oncol · March 2014 BACKGROUND: Src kinase inhibition has been shown to augment the efficacy of chemotherapy. Dasatinib, a dual Src/Abl kinase inhibitor approved for the treatment of CML, is under investigation as monotherapy for tumors with abnormal Src signaling, such as me ... Full text Link to item Cite

Isolated limb infusion as a model to test new agents to treat metastatic melanoma.

Journal Article J Surg Oncol · March 2014 The limb model of in-transit disease can expand our understanding of treating melanoma because of the ease of obtaining tissue biopsies for correlative studies and the availability of preclinical animal models that allow validation of novel therapeutic str ... Full text Link to item Cite

Predicting disease progression after regional therapy for in-transit melanoma.

Journal Article JAMA Surg · June 2013 IMPORTANCE: Although approximately 30% to 50% of patients experience a complete response after regional chemotherapy for in-transit melanoma, a subset of patients will develop rapidly progressive disease. In the current era of an expanding armamentarium, i ... Full text Link to item Cite

Examining reoperation and readmission after hepatic surgery.

Journal Article J Am Coll Surg · May 2013 BACKGROUND: Although the perioperative mortality from hepatic resection has improved considerably, this procedure is still associated with substantial morbidity and resource use. The goal of this investigation was to characterize the incidence, patterns, a ... Full text Link to item Cite

A collaborative care model for peri-operative care of older adults.

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2013 Link to item Cite

Simultaneous diaphragm and liver resection: a propensity-matched analysis of postoperative morbidity.

Journal Article J Am Coll Surg · March 2013 BACKGROUND: Although a concomitant diaphragm resection might be required at the time of hepatectomy to achieve tumor-free surgical margins, studies addressing its effect on postoperative morbidity and mortality have been inconclusive. The objective of this ... Full text Link to item Cite

Laparoscopic versus open Hartmann procedure for the emergency treatment of diverticulitis: a propensity-matched analysis.

Journal Article Dis Colon Rectum · January 2013 BACKGROUND: A laparoscopic approach has been proposed to reduce the high morbidity and mortality associated with the Hartmann procedure for the emergency treatment of diverticulitis. OBJECTIVE: The objective of our study was to determine whether a laparosc ... Full text Link to item Cite

A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion.

Journal Article Cancer · December 15, 2012 BACKGROUND: Although studies of melphalan-based isolated limb infusion (ILI) combine data from upper extremity (UE) treatments with those from lower extremity (LE) treatments, differences between the 2 may be clinically important. METHODS: Candidates for U ... Full text Link to item Cite

Management and recurrence patterns of desmoids tumors: a multi-institutional analysis of 211 patients.

Journal Article Ann Surg Oncol · December 2012 BACKGROUND: Desmoid tumors are rare soft-tissue neoplasms with limited data on their management. We sought to determine the rates of recurrence following surgery for desmoid tumors and identify factors predictive of disease-free survival. METHODS: Between ... Full text Link to item Cite

Analysis of the treatment of congenital vascular malformations using a multidisciplinary approach.

Journal Article J Vasc Surg · November 2012 BACKGROUND: Vascular malformations are a rare and complex group of lesions which may present serious pitfalls in diagnosis and management. We sought to evaluate the efficacy and safety of our imaging protocol and therapeutic algorithm in the treatment of l ... Full text Link to item Cite

A comparison of tibial artery bypass performed with heparin-bonded expanded polytetrafluoroethylene and great saphenous vein to treat critical limb ischemia.

Journal Article J Vasc Surg · October 2012 BACKGROUND: Expanded polytetrafluoroethylene (ePTFE) bonded with heparin (HePTFE) has been reported to perform equivalent to saphenous vein graft (SVG) for below-knee bypass. This series examines outcomes for tibial artery bypass using HePTFE and SVG over ... Full text Link to item Cite

Advanced age is an independent predictor for increased morbidity and mortality after emergent surgery for diverticulitis.

Journal Article Surgery · September 2012 BACKGROUND: The objectives of our study were to determine the association between age and postoperative outcomes after emergency surgery for diverticulitis and to identify risk factors for postoperative mortality among elderly patients. METHODS: All patien ... Full text Link to item Cite

The role of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis and management of patients with vascular malformations.

Journal Article J Vasc Surg · September 2012 OBJECTIVE: Vascular malformations are uncommon but may confer significant morbidity. Limitations in diagnosis and treatment result from inadequate classification schema and diagnostic algorithms. The crucial distinction is between high-flow and low-flow le ... Full text Link to item Cite

An expanded series of distal bypass using the distal vein patch technique to improve prosthetic graft performance in critical limb ischemia.

Journal Article Eur J Vasc Endovasc Surg · August 2012 OBJECTIVES: The endovascular first approach has led to increasing complexity for surgical bypass especially in those patients without autogenous conduit. The use of vein interposed at the distal anastomosis has been reported to improve the results of prost ... Full text Link to item Cite

Impact of simultaneous diaphragm resection during hepatectomy for treatment of metastatic colorectal cancer.

Journal Article J Gastrointest Surg · August 2012 INTRODUCTION: For colorectal cancer patients with liver metastases involving the hepatic dome or invading the diaphragm, a concomitant diaphragm resection is often required to achieve negative surgical margins. The purpose of this study is to determine whe ... Full text Link to item Cite

A 6-year experience treating vascular malformations with foam sclerotherapy.

Journal Article Perspect Vasc Surg Endovasc Ther · June 2012 In this study, the authors present an analysis of the outcomes of 105 low-flow vascular malformation patients treated over a 6-year period and report specific lesion characteristics that correlate with those vascular malformations that will benefit from so ... Full text Link to item Cite

Abstract 2012: MAP kinase activation and suppression of anti-apoptotic Bcl-2 family members are associated with induction of apoptotic death in melanoma cells following down-regulation of glutathione S-transferase P1

Journal Article Cancer Research · April 15, 2012 AbstractIntroduction. The multifunctional protein, glutathione S-transferase P1, GSTP1, is frequently overexpressed in malignant melanoma and has been associated with increased tumor growth and resistance to ... Full text Cite

Airway interventions in children with Pierre Robin Sequence.

Journal Article Otolaryngol Head Neck Surg · June 2008 OBJECTIVE: To describe the interventions required for successful airway management in children with Pierre Robin Sequence (PRS). STUDY DESIGN: Case series. SUBJECTS AND METHODS: The records of both a cleft and craniofacial clinic and a pediatric otolaryngo ... Full text Link to item Cite

Resolving feeding difficulties with early airway intervention in Pierre Robin Sequence.

Journal Article Laryngoscope · January 2008 OBJECTIVES/HYPOTHESIS: To observe rates of gastrostomy tube (g-tube) placement in Pierre Robin Sequence (PRS) and to determine whether relieving airway obstruction solves feeding difficulties. STUDY DESIGN: All PRS referrals to a multidisciplinary cleft te ... Full text Link to item Cite