Scholars@Duke
Michael Tracey Stang

Michael Tracey Stang

Associate Professor of Surgery
Surgical Oncology
michaelt.stang@duke.edu
3404 Wake Forest Road, Suite 202, Raleigh, NC 27609

Selected Publications

Medullary thyroid cancer with RET V804M mutation: more indolent than expected?

Journal Article Surgery · January 2023 BACKGROUND: Significant genotype-phenotype variability among multiple endocrine neoplasia type 2A patients with a RET V804M mutation has been reported. METHODS: Patients with a RET V804M mutation treated at a single center were identified (January 1996-Dec ... Full text Link to item Cite

Guideline Adherence and Practice Patterns in the Management of Medullary Thyroid Cancer.

Journal Article J Surg Res · January 2023 INTRODUCTION: Little is known about nationwide practice patterns for the management medullary thyroid cancer (MTC) in relation to the 2015 American Thyroid Association guidelines and their impact on survival. METHODS: Using the Surveillance, Epidemiology, ... Full text Link to item Cite

Salvage Cryoablation for Local Recurrences of Thyroid Cancer Inseparable from the Trachea and Neurovascular Structures.

Journal Article J Vasc Interv Radiol · January 2023 PURPOSE: To demonstrate safety, feasibility, and effectiveness of cryoablation of recurrent papillary thyroid cancer ineligible for reoperation because of scarring, eligible for focal ablation as defined within 2015 American Thyroid Association guideline s ... Full text Link to item Cite

Outcomes of concurrent parathyroidectomy and thyroidectomy among CESQIP surgeons.

Journal Article Am J Surg · November 2022 BACKGROUND: Studies comparing endocrine-specific outcomes following parathyroidectomy (PTx) versus concurrent parathyroidectomy and thyroidectomy (PTx + Tx) are few. METHODS: 10,019 patients were selected from the Collaborative Endocrine Surgery Quality Im ... Full text Link to item Cite

Patient-Reported Outcomes Following Total Thyroidectomy for Graves' Disease.

Journal Article Thyroid · January 2022 Background: Graves' disease accounts for ∼80% of all cases of hyperthyroidism and is associated with significant morbidity and decreased quality of life. Understanding the association of total thyroidectomy with patient-reported quality-of-life and thyroid ... Full text Link to item Cite

Arterial Embolization for Thyroid Goiter, Graves’ Disease, and Thyroid Malignancy

Chapter · January 1, 2022 Minimally invasive endocrine interventions have the potential to complement and broaden options for thyroid care. Since the initial work in this field, there has been a technological renaissance allowing radial artery access, smaller microcatheter and embo ... Full text Cite

Severe Hypocalcemia After Thyroidectomy: An Analysis of 7366 Patients.

Journal Article Ann Surg · December 1, 2021 OBJECTIVE: The aim of the study was to determine severe hypocalcemia rate following thyroidectomy and factors associated with its occurrence. BACKGROUND: Hypocalcemia is the most common complication after thyroidectomy. Severe post-thyroidectomy hypocalcem ... Full text Link to item Cite

Postoperative Surveillance in Older Adults With T1N0M0 Low-risk Papillary Thyroid Cancer.

Journal Article J Surg Res · August 2021 BACKGROUND: The frequency and cost of postoperative surveillance for older adults (>65 y) with T1N0M0 low-risk papillary thyroid cancer (PTC) have not been well studied. METHODS: Using the SEER-Medicare (2006-2013) database, frequency and cost of surveilla ... Full text Link to item Cite

Recurrent Laryngeal Nerve Injury After Thyroid Surgery: An Analysis of 11,370 Patients.

Journal Article J Surg Res · November 2020 BACKGROUND: Recurrent laryngeal nerve (RLN) injury is a well-known, potentially serious complication of thyroid surgery. We investigated factors associated with RLN injury during thyroid surgery using a multi-institutional data set. MATERIALS AND METHODS: ... Full text Link to item Cite

Patient Preferences Around Extent of Surgery in Low-Risk Thyroid Cancer: A Discrete Choice Experiment.

Journal Article Thyroid · July 2020 Background: Patient preferences pertaining to surgical options for thyroid cancer management are not well studied. Our aim was to conduct a discrete choice experiment (DCE) to characterize participants' views on the relative importance of various risks and ... Full text Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Patient selection and outcomes of laparoscopic transabdominal versus posterior retroperitoneal adrenalectomy among surgeons in the Collaborative Endocrine Surgery Quality Improvement Program (CESQIP).

Journal Article Surgery · January 2020 BACKGROUND: Laparoscopic adrenalectomy can be performed using a transabdominal or posterior retroperitoneal approach. Choosing the optimal approach can be challenging. METHODS: Using data from the Collaborative Endocrine Surgery Quality Improvement Program ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Adequacy of Lymph Node Yield for Papillary Thyroid Cancer: An Analysis of 23,131 Patients.

Journal Article J Surg Res · December 2019 BACKGROUND: Threshold numbers for defining adequacy of lymph node (LN) yield have been determined for evaluation of occult nodal disease during papillary thyroid cancer (PTC) surgery. This study assesses the prevalence of adequate LN yield and estimates it ... Full text Link to item Cite

Extent of surgery for low-risk thyroid cancer in the elderly: Equipoise in survival but not in short-term outcomes.

Journal Article Surgery · November 2019 BACKGROUND: Total thyroidectomy is more common than lobectomy for low-risk papillary thyroid cancer, despite equipoise in survival. Because postoperative morbidity increases with age, we aimed to investigate how the extent of thyroidectomy affects short-te ... Full text Link to item Cite

A DIRECT COMPARISON OF THE ATA AND TI-RADS ULTRASOUND SCORING SYSTEMS.

Journal Article Endocr Pract · May 2019 Objective: This study compares the American Thyroid Association (ATA) classification system with the 2017 American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) for predicting cancer risk in thyroid nodules. Methods: This i ... Full text Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

The devil is in the details: Assessing treatment and outcomes of 6,795 patients undergoing remedial parathyroidectomy in the Collaborative Endocrine Surgery Quality Improvement Program.

Journal Article Surgery · January 2019 BACKGROUND: Multi-institutional data describing remedial parathyroidectomy compared with index parathyroidectomy are scarce. METHODS: Using data in the Collaborative Endocrine Surgery Quality Improvement Program (2014-2017), baseline characteristics and ou ... Full text Link to item Cite

Gasless Transaxillary Endoscopic Thyroidectomy with Robotic Assistance: A High-Volume Experience in North America.

Journal Article Thyroid · December 2018 BACKGROUND: Since its introduction nine years ago, gasless transaxillary thyroidectomy with robotic assistance (RT) has achieved a relatively limited application in North America. This study aimed to assess the outcomes of RT in a recent large, diverse Nor ... Full text Link to item Cite

Impact of Micro- and Macroscopically Positive Surgical Margins on Survival after Resection of Adrenocortical Carcinoma.

Journal Article Ann Surg Oncol · May 2018 PURPOSE: Adrenocortical carcinoma (ACC) is a rare, aggressive cancer; complete surgical resection offers the best chance for long-term survival. The impact of surgical margin status on survival is poorly understood. Our objective was to determine the assoc ... Full text Link to item Cite

Each procedure matters: threshold for surgeon volume to minimize complications and decrease cost associated with adrenalectomy.

Journal Article Surgery · January 2018 BACKGROUND: An association has been suggested between increasing surgeon volume and improved patient outcomes, but a threshold has not been defined for what constitutes a "high-volume" adrenal surgeon. METHODS: Adult patients who underwent adrenalectomy by ... Full text Link to item Cite

Subtotal vs. total parathyroidectomy with autotransplantation for patients with renal hyperparathyroidism have similar outcomes.

Journal Article Am J Surg · November 2017 BACKGROUND: The optimal surgery for patients with renal hyperparathyroidism has been controversial, as either subtotal parathyroidectomy (subtotal PTX) or total parathyroidectomy with auto-transplantation (total PTX-AT) may be employed. METHODS: Adult pati ... Full text Link to item Cite

Projecting Survival in Papillary Thyroid Cancer: A Comparison of the Seventh and Eighth Editions of the American Joint Commission on Cancer/Union for International Cancer Control Staging Systems in Two Contemporary National Patient Cohorts.

Journal Article Thyroid · November 2017 BACKGROUND: This study aims to compare the seventh and eighth editions of the American Joint Commission on Cancer/Union for International Cancer Control (AJCC/UICC) tumor, node, metastasis staging system for patients with papillary thyroid cancer (PTC) in ... Full text Link to item Cite

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.

Journal Article Nat Commun · October 3, 2017 Although diabetes results in part from a deficiency of normal pancreatic beta cells, inducing human beta cells to regenerate is difficult. Reasoning that insulinomas hold the "genomic recipe" for beta cell expansion, we surveyed 38 human insulinomas to obt ... Full text Link to item Cite

Controversies in the Management of Low-Risk Differentiated Thyroid Cancer.

Journal Article Endocr Rev · August 1, 2017 Controversy exists over optimal management of low-risk differentiated thyroid cancer. This controversy occurs in all aspects of management, including surgery, use of radioactive iodine for remnant ablation, thyroid hormone supplementation, and long-term su ... Full text Link to item Cite

Racial Disparities in Differentiated Thyroid Cancer: Have We Bridged the Gap?

Journal Article Thyroid · June 2017 BACKGROUND: Racial disparities in the management of differentiated thyroid cancer (DTC) exist in the United States. There is a paucity of data examining their temporal trends. It was hypothesized that racial disparities in care provided to patients with DT ... Full text Link to item Cite

Surgical management of medullary thyroid carcinoma.

Journal Article Updates Surg · June 2017 Medullary thyroid cancer (MTC) is a malignant tumor of the parafollicular C cells of the thyroid and comprises only 1-2% of all thyroid cancer cases. Unlike most differentiated thyroid cancer, MTC is associated with a mean survival of 8.6 years and account ... Full text Link to item Cite

Transiently expressed ATG16L1 inhibits autophagosome biogenesis and aberrantly targets RAB11-positive recycling endosomes.

Journal Article Autophagy · February 2017 The membrane source for autophagosome biogenesis is an unsolved mystery in the study of autophagy. ATG16L1 forms a complex with ATG12-ATG5 (the ATG16L1 complex). The ATG16L1 complex is recruited to autophagic membranes to convert MAP1LC3B-I to MAP1LC3B-II. ... Full text Link to item Cite

Comparative characteristics of primary hyperparathyroidism in pediatric and young adult patients.

Journal Article Surgery · October 2016 BACKGROUND: Primary hyperparathyroidism is rare in pediatric patients. Our study aim was to compare primary hyperparathyroidism in pediatric (<19 years) and young adult (19-29 years) patients. METHODS: A prospectively collected database from a single, high ... Full text Link to item Cite

T1a Versus T1b Differentiated Thyroid Cancers: Do We Need to Make the Distinction?

Journal Article Thyroid · August 2016 BACKGROUND: The 7th edition of the American Joint Committee on Cancer (AJCC) staging system trialed a subdivision of T1 tumors into T1a (<1 cm) and T1b (1.0-2 cm). The 2009 American Thyroid Association (ATA) guidelines recommended total thyroidectomy for t ... Full text Link to item Cite

Safety in Numbers: Progressive Implementation of a Robotics Program in an Academic Surgical Oncology Practice.

Journal Article Surg Innov · August 2016 Background Robotic-assisted surgery has potential benefits over laparoscopy yet little has been published on the integration of this platform into complex surgical oncology. We describe the outcomes associated with integration of robotics into a large surg ... Full text Link to item Cite

Management of the central and lateral neck in patients with differentiated thyroid cancer

Journal Article Current Surgery Reports · July 1, 2016 Purpose of Review The incidence of differentiated thyroid cancer, including papillary, follicular, and Hürthle cell histologies, is increasing rapidly in the United States. It is associated with significant risk of locoregional lymph node metastasis; this ... Full text Cite

American Thyroid Association Statement on Remote-Access Thyroid Surgery.

Journal Article Thyroid · March 2016 BACKGROUND: Remote-access techniques have been described over the recent years as a method of removing the thyroid gland without an incision in the neck. However, there is confusion related to the number of techniques available and the ideal patient select ... Full text Link to item Cite

Erratum.

Journal Article Autophagy · 2016 Full text Link to item Cite

Hürthle cell carcinoma: current perspectives.

Journal Article Onco Targets Ther · 2016 Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of ... Full text Open Access Link to item Cite

Current Guidelines for Postoperative Treatment and Follow-Up of Well-Differentiated Thyroid Cancer.

Journal Article Surg Oncol Clin N Am · January 2016 Well-differentiated thyroid cancer is increasing in incidence but the disease-specific mortality remains very low. The only effective adjuvant treatment is radioactive iodine ablation. Guidelines regarding the use and dosage of radioactive iodine depend on ... Full text Link to item Cite

Does impotence improve after parathyroidectomy in men with primary hyperparathyroidism?

Journal Article Surgery · January 2016 BACKGROUND: Erectile dysfunction (ED) is a common diagnosis associated with age, hypertension, cardiovascular disease, and diabetes. Primary hyperparathyroidism (PHP) is also seen with these comorbidities, but its association with ED has yet to be studied. ... Full text Link to item Cite

Adrenal Imaging Features Predict Malignancy Better than Tumor Size.

Journal Article Ann Surg Oncol · December 2015 INTRODUCTION: In adrenal tumors, size ≥ 4 cm has been an indication for adrenalectomy due to concern for malignancy. We compared mass size to imaging features (ImF) for accuracy in diagnosing adrenal malignancy. METHODS: Data were retrieved for 112 consecu ... Full text Link to item Cite

The clinical importance of parathyroid atypia: is long-term surveillance necessary?

Journal Article Surgery · October 2015 BACKGROUND: The uncommon diagnosis of atypical parathyroid adenoma (APA) creates a clinical conundrum for surveillance. We evaluated a large series of APA to determine long-term outcomes. METHODS: Prospectively collected data were retrieved for patients wi ... Full text Link to item Cite

Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients.

Journal Article Ann Surg · September 2015 OBJECTIVES: To correlate thyroid cancer genotype with histology and outcomes. BACKGROUND: The prognostic significance of molecular signature in thyroid cancer (TC) is undefined but can potentially change surgical management. METHODS: We reviewed a consecut ... Full text Link to item Cite

IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition.

Journal Article Cancer Biol Ther · 2015 Interferon Regulatory Factor (IRF)-1, originally identified as a transcription factor of the human interferon (IFN)-β gene, mediates tumor suppression and may inhibit oncogenesis. We have shown that IRF-1 in human breast cancer cells results in the down-re ... Full text Link to item Cite

Fibromyalgia symptoms and medication requirements respond to parathyroidectomy.

Journal Article Surgery · December 2014 BACKGROUND: Fibromyalgia (FM), an ill-defined symptom complex, is characterized by musculoskeletal pain, headache, depression, fatigue, and cognitive decline, symptoms also seen commonly in primary hyperparathyroidism (PHP). Prevalence of concurrent PHP an ... Full text Link to item Cite

Surgeon volume and adequacy of thyroidectomy for differentiated thyroid cancer.

Journal Article Surgery · December 2014 INTRODUCTION: We aimed to determine influence of surgeon volume on (1) frequency of appropriate initial surgery for differentiated thyroid cancer (DTC) and (2) completeness of resection. METHODS: We reviewed all initial thyroidectomies (Tx; lobectomy and t ... Full text Link to item Cite

PAX8/PPARγ rearrangement in thyroid nodules predicts follicular-pattern carcinomas, in particular the encapsulated follicular variant of papillary carcinoma.

Journal Article Thyroid · September 2014 BACKGROUND: PAX8/PPARγ rearrangement is a common genetic alteration in follicular thyroid carcinoma (FTC) and has been reported with variable frequency in papillary thyroid carcinoma (PTC). The diagnostic and phenotypic features of thyroid nodules positive ... Full text Link to item Cite

A clinical algorithm for fine-needle aspiration molecular testing effectively guides the appropriate extent of initial thyroidectomy.

Journal Article Ann Surg · July 2014 OBJECTIVE: To test whether a clinical algorithm using routine cytological molecular testing (MT) promotes initial total thyroidectomy (TT) for clinically significant thyroid cancer (sTC) and/or correctly limits surgery to lobectomy when appropriate. BACKGR ... Full text Link to item Cite

The small abnormal parathyroid gland is increasingly common and heralds operative complexity.

Journal Article World J Surg · June 2014 BACKGROUND: Over decades, improvements in presymptomatic screening and awareness of surgical benefits have changed the presentation and management of primary hyperparathyroidism (PHPT). Unrecognized multiglandular disease (MGD) remains a major cause of ope ... Full text Link to item Cite

Thyroid nodules (≥4 cm): can ultrasound and cytology reliably exclude cancer?

Journal Article World J Surg · March 2014 BACKGROUND: Whether a threshold nodule size should prompt diagnostic thyroidectomy remains controversial. We examined a consecutive series of patients who all had thyroidectomy for a ≥4 cm nodule to determine (1) the incidence of thyroid cancer (TC) and (2 ... Full text Link to item Cite

The final intraoperative parathyroid hormone level: how low should it go?

Journal Article World J Surg · March 2014 BACKGROUND: In minimally invasive surgery for primary hyperparathyroidism (HPT), intraoperative parathyroid hormone (IOPTH) monitoring assists in obtaining demonstrably better outcomes, but optimal criteria are controversial. METHODS: The outcomes of 1,108 ... Full text Link to item Cite

Outcome and prognostic factors after adrenalectomy for patients with distant adrenal metastasis.

Journal Article Ann Surg Oncol · October 2013 BACKGROUND: The purpose of this study was to describe a single-institution experience with adrenal metastasectomy and to elucidate factors that may bear prognostic significance. METHODS: This is a single-center, retrospective review of patients with adrena ... Full text Link to item Cite

Nodule size is an independent predictor of malignancy in mutation-negative nodules with follicular lesion of undetermined significance cytology.

Journal Article Surgery · October 2013 BACKGROUND: In thyroid nodule fine-needle aspiration (FNA) cytology, the atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category has a 5-15% malignancy risk that increases to 85-99% when mutation testing fo ... Full text Link to item Cite

RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers.

Journal Article J Clin Endocrinol Metab · May 2013 INTRODUCTION: RAS mutations are common in thyroid tumors and confer a high risk of cancer when detected in fine-needle aspiration (FNA) specimens. Specific characteristics of RAS-positive thyroid cancers are not well described. METHODS: From April 2007 to ... Full text Link to item Cite

Robotic-assisted minimally invasive central pancreatectomy: technique and outcomes.

Journal Article J Gastrointest Surg · May 2013 BACKGROUND: Central pancreatectomy is a definitive treatment for low-grade tumors of the pancreatic neck that preserves pancreatic and splenic function at the potential expense of postoperative pancreatic fistula. We analyzed outcomes after robot-assisted ... Full text Link to item Cite

BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer.

Journal Article Ann Surg Oncol · January 2013 PURPOSE: This study was designed to examine whether available preoperative clinical parameters, including B-type Raf kinase (BRAF) V600E mutation status, can identify patients at risk for central compartment lymph node metastasis (CLNM). METHODS: Under an ... Full text Link to item Cite

E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I.

Journal Article PLoS One · 2013 p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified. Further, the p62-mediated protein aggregation's effect on autophagy is ... Full text Link to item Cite

The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE.

Journal Article PLoS One · 2013 LC3 is widely used marker for macroautophagy assays. After translation pro-LC3 is processed by Atg4 to expose C-terminal glycine residue for downstream conjugation reactions to accomplish the conversion of LC3-I to LC3-II. SDS-PAGE based Western blot (Wb) ... Full text Link to item Cite

Intraoperative pathologic examination in the era of molecular testing for differentiated thyroid cancer.

Journal Article J Am Coll Surg · October 2012 BACKGROUND: Diagnostic thyroidectomy is typically indicated for indeterminate thyroid cytology results. Traditionally, intraoperative pathologic examination (IOPE) helped to guide the extent of initial surgery. Preoperative molecular testing (MT) of fine n ... Full text Link to item Cite

Immediate laparoscopic adrenalectomy versus observation: cost evaluation for incidental adrenal lesions with atypical imaging characteristics.

Journal Article Am J Surg · October 2012 BACKGROUND: Because of controversy in the management of nonfunctional adrenal masses <6 cm with lipid-poor imaging characteristics, the study was conducted to compare the costs of observation versus immediate laparoscopic adrenalectomy. METHODS: A total of ... Full text Link to item Cite

Positional dyspnea and tracheal compression as indications for goiter resection.

Journal Article Arch Surg · July 2012 HYPOTHESES: Goiter is a surgically reversible cause of positional dyspnea (PD). Substernal tracheal compression (TC) predicts PD relief after thyroidectomy (Tx). DESIGN: Retrospective analysis of a prospective structured management algorithm. SETTING: Endo ... Full text Link to item Cite

Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.

Journal Article Cancer Lett · June 1, 2012 We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protein (IAP) survivin and the induction of the cyclin-dependent kinase ... Full text Link to item Cite

Suspicious ultrasound characteristics predict BRAF V600E-positive papillary thyroid carcinoma.

Journal Article Thyroid · June 2012 BACKGROUND: Current American Thyroid Association (ATA) guidelines recommend routine cervical ultrasound (US) in thyroid nodule evaluation. Specific US characteristics can help diagnose papillary thyroid carcinoma (PTC). The aim of this blinded cohort study ... Full text Link to item Cite

Cost impact of molecular testing for indeterminate thyroid nodule fine-needle aspiration biopsies.

Journal Article J Clin Endocrinol Metab · June 2012 INTRODUCTION: Molecular testing of fine-needle aspiration (FNA) results helps diagnose thyroid cancer, although the additional cost of this adjunct has not been studied. We hypothesized that FNA molecular testing of two indeterminate categories (follicular ... Full text Link to item Cite

A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinoma.

Journal Article Cancer · April 15, 2012 BACKGROUND: Thyroid papillary microcarcinoma (TPMC) is an incidentally discovered papillary carcinoma that measures ≤1.0 cm in size. Most TPMCs are indolent, whereas some behave aggressively. The objective of the study was to evaluate whether the combinati ... Full text Link to item Cite

Both BRAF V600E mutation and older age (≥ 65 years) are associated with recurrent papillary thyroid cancer.

Journal Article Ann Surg Oncol · December 2011 PURPOSE: This study was designed to examine the aggressive features of BRAF-positive papillary thyroid cancer (PTC) and association with age. METHODS: We compared the clinicopathologic parameters and BRAF V600E mutation status of 121 elderly (age ≥65 years ... Full text Link to item Cite

Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples.

Journal Article J Clin Endocrinol Metab · November 2011 CONTEXT: Thyroid nodules are common in adults, but only a small fraction of them is malignant. Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminat ... Full text Link to item Cite

Thyroid carcinoma: the surgeon's perspective.

Journal Article Radiol Clin North Am · May 2011 Surgery is often needed to diagnose thyroid cancer, but is also the initial therapeutic modality. Several current imaging techniques are important for preoperative risk stratification. By optimizing initial thyroidectomy and lymphadenectomy, accurate and a ... Full text Link to item Cite

Genotype-phenotype correlations of pheochromocytoma in two large von Hippel-Lindau (VHL) type 2A kindreds with different missense mutations.

Journal Article Am J Med Genet A · January 2011 Von Hippel-Lindau (VHL) disease type 2A is an inherited tumor syndrome characterized by predisposition to pheochromocytoma (pheo), retinal hemangioma (RA), and central nervous system hemangioblastoma (HB). Specific VHL subtypes display genotype-phenotype c ... Full text Link to item Cite

Cytoplasmic overexpression of CD95L in esophageal adenocarcinoma cells overcomes resistance to CD95-Mediated apoptosis

Journal Article Neoplasia · January 1, 2011 INTRODUCTION: The CD95/CD95L pathway plays a critical role in tissue homeostasis and immune system regulation; however, the function of this pathway in malignancy remains poorly understood. We hypothesized that CD95L expression in esophageal adenocarcinoma ... Full text Cite

Medication discontinuation after curative surgery for sporadic primary hyperparathyroidism.

Journal Article Surgery · December 2010 BACKGROUND: Although parathyroidectomy (Ptx) for sporadic primary hyperparathyroidism (PH) improves comorbidities and symptoms, routine Ptx for minimally symptomatic PH remains controversial. Whether successful Ptx translates into discontinuation or dose-r ... Full text Link to item Cite

Single nucleotide polymorphisms act as modifiers and correlate with the development of medullary and simultaneous medullary/papillary thyroid carcinomas in 2 large, non-related families with the RET V804M proto-oncogene mutation.

Journal Article Surgery · December 2010 BACKGROUND: Single nucleotide polymorphisms (SNPs) may function as modifiers of the RET proto-oncogene, resulting in the expression of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC). We present 2 non-related Italian-American famili ... Full text Link to item Cite

Recurrent hyperparathyroidism and forearm parathyromatosis after total parathyroidectomy.

Journal Article Surgery · October 2010 BACKGROUND: In multiple endocrine neoplasia type I and renal failure, the type of initial parathyroidectomy for hyperparathyroidism may influence the operative risks and development of recurrence. We compared subtotal parathyroidectomy with total parathyro ... Full text Link to item Cite

The adrenal mass: correlation of histopathology with imaging.

Journal Article Ann Surg Oncol · March 2010 BACKGROUND: Computed tomography (CT) and magnetic resonance (MR) imaging can help diagnose benign adrenal adenomas, but prior studies rely on nonoperative follow-up as proof of a lesion's benign nature. We examined adrenalectomy tissues to determine if ima ... Full text Link to item Cite

Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation.

Journal Article Surgery · December 2009 BACKGROUND: To date, a mutation of the BRAF oncogene is the most common genetic alteration found in papillary thyroid carcinoma (PTC) and is associated with extrathyroidal extension, lymph node metastasis, and tumor recurrence. It is not known whether pre- ... Full text Link to item Cite

Recent developments in predicting thyroid malignancy.

Journal Article Curr Opin Oncol · January 2009 PURPOSE OF REVIEW: To provide an update on potential predictors of thyroid malignancy and how their use may alter clinical management. RECENT FINDINGS: As thyroid nodules become more prevalent clinicians are increasingly impelled to identify the optimal pr ... Full text Link to item Cite

Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells.

Journal Article Oncogene · September 27, 2007 Interferon (IFN) regulatory factor-1 (IRF-1) is a transcription factor that has apoptotic anti-tumor activity. In breast cancer cell types, IRF-1 is implicated in mediating apoptosis by both novel and established anti-tumor agents, including the anti-estro ... Full text Link to item Cite

Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma.

Journal Article Neoplasia · November 2006 The hepatocyte growth factor (HGF) receptor c-Met is a tyrosine kinase receptor with established oncogenic properties. We have previously shown that c-Met is usually overexpressed in esophageal adenocarcinoma (EA), yet the implications of c-Met inhibition ... Full text Link to item Cite

The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury.

Journal Article Am J Physiol Gastrointest Liver Physiol · June 2006 Hepatic ischemia occurs in the settings of trauma, transplantation, and elective liver resections. The initiating events that account for local organ damage are only partially understood. Interferon (IFN) regulatory factor-1 (IRF-1) is a transcription fact ... Full text Link to item Cite

Ad-IRF-1 induces apoptosis in esophageal adenocarcinoma.

Journal Article Neoplasia · January 2006 The nuclear transcription factor interferon regulatory factor-1 (IRF-1) is a putative tumor suppressor, but the expression and function of IRF-1 in esophageal adenocarcinoma (EA) remain unknown. We hypothesized that IRF-1 expression was reduced or lost in ... Full text Link to item Cite

Hyperthyroidism after parathyroid exploration.

Journal Article Surgery · December 2005 BACKGROUND: We hypothesized that hyperthyroidism after parathyroid exploration may be an underreported phenomenon with a course more severe than recognized previously. METHODS: We examined pre- and postoperative thyroid function and outcomes in 199 consecu ... Full text Link to item Cite

Autoimmunity - Endocrine

Chapter · December 1, 2005 This chapter discusses endocrine autoimmunity, with a particular focus on the autoimmune thyroid diseases (AITDs). Autoimmune diseases are characterized by autoreactive lymphocytes that can cause a spectrum of disease pathology, either through the formatio ... Full text Cite

Autoimmunity - Endocrine

Chapter · December 30, 2004 This chapter discusses endocrine autoimmunity, with a particular focus on the autoimmune thyroid diseases (AITDs). Autoimmune diseases are characterized by autoreactive lymphocytes that can cause a spectrum of disease pathology, either through the formatio ... Full text Cite

Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin.

Journal Article Cancer Res · November 15, 2004 The overexpression of the inhibitor of apoptosis protein, survivin, may provide tumor cells with a distinct survival advantage in situ; hence, therapeutic strategies have been designed to inhibit its expression. In this study, we ectopically expressed the ... Full text Link to item Cite

A c-Fos- and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming growth factor-beta1.

Journal Article Oncogene · April 10, 1997 Stimulation of quiescent mouse fibroblasts with TGF-beta1 and certain other growth factors result in cooperative activation of tissue factor (TF) gene transcription, an event accompanied by the rapid entry of c-Fos into specific AP-1 DNA-binding complexes ... Full text Link to item Cite

Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: paracrine regulation by carcinoma cell-derived members of the transforming growth factor beta family.

Journal Article Cancer Res · November 1, 1996 Tissue factor (TF), the cellular initiator of the protease blood coagulation cascade, has been shown to be expressed in a variety of solid tumors, particularly those of epithelial origin. However, the mechanisms that mediate TF expression in tumors, as wel ... Link to item Cite