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Mitchell Knisely

Mitchell Knisely

Associate Professor in the School of Nursing
School of Nursing
mitchell.knisely@duke.edu
DUMC 3322, 307 Trent Drive, Office 3120, Durham, NC 27710
307 Trent Drive, DUMC 3322, Durham, NC 27710

Selected Publications

Disparities, Inequities, and Injustices in Populations With Pain: An ASPMN Position Statement.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · April 2025 Disparities, inequities, and injustices in populations with pain are historically pervasive and lead to deleterious patient outcomes and perpetuate systemic barriers to achieving equitable pain management. The American Society for Pain Management Nursing ( ... Full text Cite

Disparities, Inequities, and Injustices in Populations With Pain: Nursing Recommendations Supporting ASPMN's 2024 Position Statement.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · April 2025 The American Society for Pain Management Nursing (ASPMN) upholds the principle that all persons with pain have equal rights to evidence-based, high quality pain assessment, management, and treatment. This practice recommendation's goals are to 1) summarize ... Full text Cite

Patient-reported pregnancy loss and maternal complications: Insights from the sickle cell disease implementation consortium.

Journal Article Int J Gynaecol Obstet · March 2025 OBJECTIVE: Sickle cell disease (SCD) is associated with complications during pregnancy and can negatively influence maternal outcomes. Our study aimed to determine the prevalence and predictors of maternal morbidity among participants enrolled in an eight- ... Full text Link to item Cite

Collection of Patient-Reported Outcome Measures in Rural and Underserved Populations.

Journal Article Appl Clin Inform · March 2025 BACKGROUND:  The NIH Pragmatic Trials Collaboratory supports the design and conduct of 31 embedded pragmatic clinical trials, and many of these trials use patient-reported outcome measures (PROMs) to provide valuable information about the patients' health ... Full text Link to item Cite

Opioid-related Transitions for Chronic Pain Management: A Concept Analysis.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · March 2025 BackgroundPeople who are prescribed opioids for pain management may undergo transitions of care. However, little is known about transitions of care that involve a prescribed opioid, which may have significant consequences for people with chronic p ... Full text Cite

Participant experiences receiving acupuncture for acute musculoskeletal pain in an emergency department: A qualitative evaluation.

Journal Article PLoS One · 2025 OBJECTIVE: Acupuncture is an evidence-based pain treatment in clinic settings, but its optimal delivery has not been established in emergency departments (EDs). As part of an adaptive pragmatic randomized controlled trial of ED acupuncture for acute muscul ... Full text Link to item Cite

Exploring Perceived Barriers and Facilitators for Implementing Acute Pain Clinical Trials: A Mixed-Methods Analysis of Ketamine Infusions for Sickle Cell Pain.

Journal Article J Pain Res · 2025 OBJECTIVE: Vaso-occlusive events (VOEs) are the primary cause of acute pain in individuals with sickle cell disease (SCD), where high-dose opioids are the current standard treatment. Ketamine, a non-opioid analgesic, holds potential for managing acute SCD ... Full text Link to item Cite

Barriers and Facilitators to Integrating Acupuncture into the U.S. Health Care System: A Scoping Review.

Journal Article Journal of integrative and complementary medicine · December 2024 Background: Acupuncture is a widely practiced complementary and integrative health modality that has multiple clinical applications. The use of acupuncture in the United States is rapidly increasing. Although studies have shown the efficacy a ... Full text Cite

Comparison of Measures of Pain Intensity During Sickle Cell Disease Vaso-Occlusive Episodes.

Journal Article J Pain · December 2024 We aimed to determine the minimal clinically important difference (MCID) in pain severity and agreement between the visual analog scale (VAS) and the verbal numeric rating scale (NRS) in people with sickle cell disease (SCD) experiencing an acute vaso-occl ... Full text Link to item Cite

Black Americans With Sickle Cell Disease (SCD) Demonstrate Accelerated Epigenetic Pace of Aging Compared to Black Americans Without SCD.

Journal Article J Gerontol A Biol Sci Med Sci · November 1, 2024 BACKGROUND: Sickle cell disease (SCD) is a chronic medical condition characterized by red blood cell sickling, vaso-occlusion, hemolytic anemia, and subsequently, end-organ damage and reduced survival. Because of this significant pathophysiology and early ... Full text Link to item Cite

Epigenetic Aging Associations With Psychoneurological Symptoms and Social Functioning in Adults With Sickle Cell Disease.

Journal Article Biol Res Nurs · October 2024 Objective: Sickle cell disease (SCD), the most common inherited blood disorder in the United States, is associated with severe psychoneurological symptoms. While epigenetic age acceleration has been linked to psychoneurological symptom burden in other dise ... Full text Link to item Cite

An Adaptive Pragmatic Randomized Controlled Trial of Emergency Department Acupuncture for Acute Musculoskeletal Pain Management.

Journal Article Ann Emerg Med · October 2024 STUDY OBJECTIVE: Acute musculoskeletal pain in emergency department (ED) patients is frequently severe and challenging to treat with medications alone. The purpose of this study was to determine the feasibility, acceptability, and effectiveness of adding E ... Full text Link to item Cite

Utilizing Academic Detailing Intervention to Increase Screening, Referral, and Treatment for Opioid Use Disorder Among Primary Care Providers in Randolph County.

Journal Article Journal of addictions nursing · October 2024 BackgroundOpioid use disorder is a national epidemic that has killed over one million United States residents since 1999. Randolph County, North Carolina (NC) has a significantly higher rate of drug overdose and emergency-department-related visits ... Full text Cite

Bridging the Gap: Role of Cultural Intelligence (CQ) in Addressing Pain Inequities.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · June 2024 Full text Cite

Ethical considerations and decision making in opioid prescribing for chronic pain: A case study in rheumatology practice.

Journal Article Journal of the American Association of Nurse Practitioners · May 2024 AbstractDilemmas regarding opioid prescribing for chronic pain frequently occur within health care settings. The ethical principles of autonomy, beneficence, nonmaleficence, and justice, as well as the principles of care ethics, can assist in addr ... Full text Cite

Altered pain processing and sensitization in sickle cell disease: a scoping review of quantitative sensory testing findings.

Journal Article Pain Med · February 1, 2024 OBJECTIVES: Over 50% of adults living with sickle cell disease (SCD) have chronic pain, but the underlying mechanisms of chronic pain in this population remain unclear. Quantitative sensory testing is an important measurement tool for understanding pain an ... Full text Link to item Cite

Characterizing epigenetic aging in an adult sickle cell disease cohort.

Journal Article Blood Adv · January 9, 2024 Sickle cell disease (SCD) affects ∼100 000 predominantly African American individuals in the United States, causing significant cellular damage, increased disease complications, and premature death. However, the contribution of epigenetic factors to SCD pa ... Full text Open Access Link to item Cite

Experiences of Pain Management Nurses during the COVID-19 Pandemic: A Qualitative Study.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · December 2023 BackgroundThe knowledge and skills of pain management nurses positions them well to manage people's pain and provide critical services to patients with COVID-19.AimTo understand the personal and professional experiences and the support pa ... Full text Cite

Monitoring and responding to signals of suicidal ideation in pragmatic clinical trials: Lessons from the GRACE trial for Chronic Sickle Cell Disease Pain.

Journal Article Contemp Clin Trials Commun · December 2023 Sickle cell disease (SCD) is a hemoglobin disorder and the most common genetic disorder that affects 100,000 Americans and millions worldwide. Adults living with SCD have pain so severe that it often requires opioids to keep it in control. Depression is a ... Full text Link to item Cite

Associations between Epigenetic Age Acceleration and Psychoneurological Symptoms in Sickle Cell Disease

Conference Blood · November 2, 2023 Introduction:Sickle cell disease (SCD) affects approximately 100,000 predominantly Black or African American individuals in the United States. The disease has several acute and chronic c ... Full text Cite

Developing an Implementation Blueprint for the NIH HEAL Initiative GRACE Trial: Perspectives on Acupuncture and Guided Relaxation for Chronic Sickle Cell Disease Pain.

Journal Article J Integr Complement Med · October 2023 Objective: This study aimed to explore perspectives of people living with sickle cell disease (SCD) and SCD clinic providers and staff about the use of acupuncture and guided relaxation for treating chronic SCD pain. Data obtained were to inform an impleme ... Full text Link to item Cite

Videoconferencing of Movement-Based and Psychologically Informed Interventions for Chronic Pain: A Systematic Review and Horizon Scan.

Journal Article Telemed J E Health · September 2023 Introduction: With the coronavirus disease 2019 (COVID-19) pandemic, use of telehealth technology increased dramatically. Nonpharmacological approaches to pain management may be well suited for virtual care. Yet, it is not widely understood if this treatme ... Full text Link to item Cite

Opioid Prescribing and Process Improvement Project: A Quality Improvement Initiative

Journal Article Journal for Nurse Practitioners · September 1, 2023 Urine drug screens (UDS) and pain agreements (PAs) are important risk mitigation strategies for people on long-term opioid therapy (LTOT). This project sought to increase the use of UDS and PAs when LTOT is prescribed in outpatient settings. This quality i ... Full text Cite

Potential bias and lack of generalizability in electronic health record data: reflections on health equity from the National Institutes of Health Pragmatic Trials Collaboratory.

Journal Article J Am Med Inform Assoc · August 18, 2023 Embedded pragmatic clinical trials (ePCTs) play a vital role in addressing current population health problems, and their use of electronic health record (EHR) systems promises efficiencies that will increase the speed and volume of relevant and generalizab ... Full text Link to item Cite

Patterns of patient-reported symptoms and association with sociodemographic and systemic sclerosis disease characteristics: a scleroderma Patient-centered Intervention Network (SPIN) Cohort cross-sectional study.

Journal Article EClinicalMedicine · August 2023 BACKGROUND: Systemic sclerosis is a heterogenous disease in which little is known about patterns of patient-reported symptom clusters. We aimed to identify classes of individuals with similar anxiety, depression, fatigue, sleep disturbance, and pain sympto ... Full text Link to item Cite

Infertility and treatment-seeking practices among females and males with sickle cell disease in the Sickle Cell Disease Implementation Consortium registry.

Journal Article Pediatr Blood Cancer · July 2023 OBJECTIVE: To describe the prevalence of infertility and infertility treatment seeking among people enrolled in the Sickle Cell Disease Implementation Consortium (SCDIC) registry and identify sociodemographic and clinical correlates of infertility. DESIGN: ... Full text Link to item Cite

Equity and bias in electronic health records data.

Journal Article Contemp Clin Trials · July 2023 Embedded pragmatic clinical trials (ePCTs) are conducted during routine clinical care and have the potential to increase knowledge about the effectiveness of interventions under real world conditions. However, many pragmatic trials rely on data from the el ... Full text Link to item Cite

Original Research: The Impact of COVID-19 on Pain Care Among Older Adults.

Journal Article The American journal of nursing · June 2023 PurposeIn this qualitative descriptive study, we sought to understand the professional experiences and perceptions of pain management nurses who cared for older adults in the United States during the height of the COVID-19 pandemic.Methods Full text Cite

Hybrid effectiveness-implementation trial of guided relaxation and acupuncture for chronic sickle cell disease pain (GRACE): A protocol.

Journal Article Contemporary clinical trials communications · April 2023 BackgroundPeople with sickle cell disease frequently use complementary and integrative therapies to cope with their pain, yet few studies have evaluated their effectiveness. The 3-arm, 3-site pragmatic Hybrid Effectiveness-implementation Trial of ... Full text Cite

Evaluating Associations between Average Pain Intensity and Genetic Variation in People with Sickle Cell Disease: An Exploratory Study.

Journal Article Pain Manag Nurs · February 2023 BACKGROUND: Pain is one of the most common and deleterious symptoms experienced by individuals with sickle cell disease (SCD). There is a paucity of studies identifying potential genetic mechanisms of pain in this population. AIM: Examine associations betw ... Full text Link to item Cite

The Role of Biomarkers in Understanding and Managing Pain: Nursing Contributions in the Precision Health Era.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · February 2023 Full text Cite

Acupuncture for acute musculoskeletal pain management in the emergency department and continuity clinic: a protocol for an adaptive pragmatic randomised controlled trial.

Journal Article BMJ Open · September 23, 2022 INTRODUCTION: Chronic musculoskeletal pain causes a significant burden on health and quality of life and may result from inadequate treatment of acute musculoskeletal pain. The emergency department (ED) represents a novel setting in which to test non-pharm ... Full text Link to item Cite

Evaluation of the Use of Telehealth Video Visits for Veterans With Chronic Pain.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · August 2022 BackgroundTelehealth video visits are essential for delivering timely care while mitigating exposure during the COVID-19 pandemic. Telehealth video visits have the potential to improve missed appointments, reduce costs associated with Veterans Aff ... Full text Cite

Pain Management Nurses' Roles During the COVID-19 Pandemic.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · February 2022 BackgroundMillions of people globally have been affected by the Covid-19 pandemic. It's impact on pain management nurses roles' remains unknown.AimsTo explore role changes among pain management nurses performing patient care during the Co ... Full text Cite

Brief Behavioral Therapy and Bupropion for Sleep and Fatigue in Young Adults With Crohn's Disease: An Exploratory Open Trial Study.

Journal Article Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · January 2022 Background/aimsSleep disturbances and fatigue are common symptoms amongst patients with Crohn's disease (CD). The aim of this study was to test the feasibility and effects of a pragmatic, stepped-care intervention for the treatment of poor sleep q ... Full text Cite

Severe Persistent Pain and Inflammatory Biomarkers in Sickle Cell Disease: An Exploratory Study.

Journal Article Biol Res Nurs · January 2022 BACKGROUND: Severe pain is among the most common and deleterious symptoms experienced by individuals with sickle cell disease (SCD), of whom more than 50% report chronic pain. Despite this, the understanding of the biological contributors to persistent sev ... Full text Link to item Cite

Transitioning your course to online: High-yield modifications for success.

Journal Article Currents in pharmacy teaching & learning · September 2021 IntroductionFaculty everywhere are struggling to transition their on-campus courses to an online format due to the COVID-19 pandemic. We transitioned our graduate pathophysiology and clinical pharmacology courses for advanced practice providers fr ... Full text Cite

Severe Pain Profiles and Associated Sociodemographic and Clinical Characteristics in Individuals With Sickle Cell Disease.

Journal Article Clin J Pain · September 1, 2021 OBJECTIVE: The aim of this study was to identify classes of individuals with sickle cell disease (SCD) who share distinct severe pain profiles and evaluate differences in demographic, clinical, and psychosocial characteristics between classes. METHODS: Thi ... Full text Link to item Cite

Engaging Pain Management Nurses in Research and Evidence-Based Practice.

Journal Article Pain management nursing : official journal of the American Society of Pain Management Nurses · June 2021 Full text Cite

Self-management interventions in systemic sclerosis: A systematic review.

Journal Article Res Nurs Health · April 2021 Systemic sclerosis is a rare and incurable autoimmune disease in which patients are challenged with self-managing their disease. Systematic evaluation of the essential self-management intervention components and self-management outcomes is necessary to ass ... Full text Link to item Cite

Pain and Self-Efficacy Among Patients With Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study.

Journal Article Nursing research · January 2021 BackgroundPain is one of the most common symptoms affecting patients with systemic sclerosis; however, little is known about the relationship between self-efficacy and pain and changes in pain over time.ObjectivesThe purpose of this study ... Full text Cite

Sex-based differences in the manifestations and complications of sickle cell disease: Report from the Sickle Cell Disease Implementation Consortium.

Journal Article PLoS One · 2021 INTRODUCTION: Sex-based clinical outcome differences in sickle cell disease (SCD) remain largely unknown despite evidence that female sex is associated with an increased lifespan. To better characterize sex-based differences in SCD, we assessed pain, treat ... Full text Link to item Cite

Sex Based Differences in Sickle Cell Disease

Conference Blood · November 5, 2020 IntroductionSickle cell disease (SCD) is the most common inherited blood disorders in the United States. The disease predominantly affects African Americans with 1 out of every 365 individuals born with SCD. The dis ... Full text Cite

Predictors of Maternal Morbidity Among Participants Enrolled in the Sickle Cell Disease Implementation Consortium Registry

Conference Blood · November 5, 2020 IntroductionPregnancy in sickle cell disease (SCD) is associated with an exacerbation of SCD-related complications and an increased risk of maternal complications. The increased risk is partly due to physiologic ada ... Full text Cite

Patient-reported outcomes in sickle cell disease and association with clinical and psychosocial factors: Report from the sickle cell disease implementation consortium.

Journal Article Am J Hematol · September 2020 Understanding patient experiences, quality of life, and treatment needs in individuals with sickle cell disease (SCD) is essential in promoting health and well-being. We used measures from the Adult Sickle Cell Quality of Life Measurement Information Syste ... Full text Link to item Cite

Cytokine Genetic Variants and Health-Related Quality of Life in Crohn's Disease: An Exploratory Study.

Journal Article Biological research for nursing · October 2019 BackgroundCrohn's disease (CD) is an inflammatory condition that has deleterious effects on patients' health-related quality of life (HRQoL). Demographic, clinical, and psychosocial factors contribute to variability in HRQoL; however, the influenc ... Full text Cite

Associations Between Catecholaminergic and Serotonergic Genes and Persistent Arm Pain Severity Following Breast Cancer Surgery.

Journal Article The journal of pain · September 2019 Persistent arm pain is a common problem after breast cancer surgery. Little is known about genetic factors that contribute to this type of postsurgical pain. Study purpose was to explore associations between persistent arm pain phenotypes and genetic polym ... Full text Cite

Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms.

Journal Article Biological research for nursing · July 2019 Incorporating biologically based data into symptom science research can contribute substantially to understanding commonly experienced symptoms across chronic conditions. The purpose of this literature review was to identify functional polymorphisms associ ... Full text Cite

Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery.

Journal Article The journal of pain · October 2018 Genetic variations in the catecholaminergic and serotonergic pathways may contribute to the development and severity of persistent breast pain. However, investigations of these associations are limited. The purpose of this study was to evaluate for associa ... Full text Cite

Opioid misuse in gastroenterology and non-opioid management of abdominal pain.

Journal Article Nature reviews. Gastroenterology & hepatology · March 2018 Opioids were one of the earliest classes of medications used for pain across a variety of conditions, but morbidity and mortality have been increasingly associated with their chronic use. Despite these negative consequences, chronic opioid use is increasin ... Full text Cite

CYP2D6 drug-gene and drug-drug-gene interactions among patients prescribed pharmacogenetically actionable opioids.

Journal Article Applied nursing research : ANR · December 2017 PurposeWhen codeine and tramadol are used for pain management, it is imperative that nurses are able to assess for potential drug-gene and drug-drug-gene interactions that could adversely impact drug metabolism and ultimately pain relief. Both dru ... Full text Cite

Cytokine Gene Polymorphisms Associated With Symptom Clusters in Oncology Patients Undergoing Radiation Therapy.

Journal Article Journal of pain and symptom management · September 2017 ContextMost of the reviews on the biological basis for symptom clusters suggest that inflammatory processes are involved in the development and maintenance of the symptom clusters. However, no studies have evaluated for associations between geneti ... Full text Cite

Pillbox intervention fidelity in medication adherence research: A systematic review.

Journal Article Nursing outlook · July 2017 BackgroundPillboxes are widely available, have evidence of effectiveness, but translating pillboxes in self-management interventions requires an understanding of intervention components.PurposeTo review components of intervention design, ... Full text Cite

Impact of Tobacco Quitlines on Smoking Cessation in Persons With Mental Illness: A Systematic Review.

Journal Article Journal of drug education · March 2017 Persons with mental illness smoke at rates two to four times higher than do persons without mental illness and comprise 30.9% of the U.S. tobacco market. Given the prevalence of mental illness and the known detrimental effects of tobacco, concerted efforts ... Full text Cite

Self-weighing in weight management interventions: A systematic review of literature.

Journal Article Obesity research & clinical practice · September 2016 BackgroundSelf-weighing increases a person's self-awareness of current weight and weight patterns. Increased self-weighing frequency can help an individual prevent weight gain. Literature, however, is limited in describing variability in self-weig ... Full text Cite

Using a Person-Oriented Approach in Nursing Research.

Journal Article Western journal of nursing research · April 2016 The purpose of this article was to provide an overview of the person-oriented approach, describe empirical examples of its use, and discuss how the approach may be used in nursing research. The person-oriented approach consists of theoretical and methodolo ... Full text Cite

Pharmacogenomically actionable medications in a safety net health care system.

Journal Article SAGE open medicine · January 2016 ObjectivePrior to implementing a trial to evaluate the economic costs and clinical outcomes of pharmacogenetic testing in a large safety net health care system, we determined the number of patients taking targeted medications and their clinical ca ... Full text Cite

Complexities of Medication Management Across Care Transitions: A Case Report.

Journal Article Clinical nurse specialist CNS · September 2015 PurposeThe purpose of this article is to identify medication-related considerations for clinical nurse specialist practice by presenting a case report detailing the complexities of medication management, unresolved medication discrepancies, and re ... Full text Cite

Perceived importance of teaching characteristics in clinical nurse specialist preceptors.

Journal Article Journal of professional nursing : official journal of the American Association of Colleges of Nursing · May 2015 UnlabelledAdvanced practice nursing education includes a minimum of 500 hours of supervised clinical practicum, with practicing clinicians serving as preceptors providing the bulk of the supervision. Preceptor behaviors and teaching skills can sig ... Full text Cite

Pharmacogenomics in the nursing literature: an integrative review.

Journal Article Nursing outlook · July 2014 BackgroundPharmacogenomics is a rapidly growing component of personalized health care, and nurses must be competent to deliver genomic-focused nursing care.MethodsWe conducted an integrative review of pharmacogenomics in the nursing liter ... Full text Cite

Exploring Characteristics of an Advanced Nursing Assessment

Conference CLINICAL NURSE SPECIALIST · May 1, 2012 Link to item Cite