Potential bias and lack of generalizability in electronic health record data: reflections on health equity from the National Institutes of Health Pragmatic Trials Collaboratory.
Embedded pragmatic clinical trials (ePCTs) play a vital role in addressing current population health problems, and their use of electronic health record (EHR) systems promises efficiencies that will increase the speed and volume of relevant and generalizable research. However, as the number of ePCTs using EHR-derived data grows, so does the risk that research will become more vulnerable to biases due to differences in data capture and access to care for different subsets of the population, thereby propagating inequities in health and the healthcare system. We identify 3 challenges-incomplete and variable capture of data on social determinants of health, lack of representation of vulnerable populations that do not access or receive treatment, and data loss due to variable use of technology-that exacerbate bias when working with EHR data and offer recommendations and examples of ways to actively mitigate bias.
Duke Scholars
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- United States
- National Institutes of Health (U.S.)
- Medical Informatics
- Humans
- Health Equity
- Electronic Health Records
- Delivery of Health Care
- Bias
- 46 Information and computing sciences
- 42 Health sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- United States
- National Institutes of Health (U.S.)
- Medical Informatics
- Humans
- Health Equity
- Electronic Health Records
- Delivery of Health Care
- Bias
- 46 Information and computing sciences
- 42 Health sciences