Alan David Proia

Journal Article Ophthalmic Plast Reconstr Surg · March 2025 A woman in her early 20s underwent excision of a 6-mm diameter, tender, mobile mass in the temporal left upper eyelid associated with eyelid swelling and blurred vision. Surgery disclosed a large tarsal lesion that appeared to be a cyst but was found to be ... Full text Link to item Cite

Dermoid Cyst of Conjunctival Origin Attached to the Tarsus in a Pediatric Patient.

Journal Article Ophthalmic Plast Reconstr Surg · March 2025 Dermoid cysts of cutaneous origin are common orbital lesions, whereas dermoid cysts of conjunctival origin are rare. The authors present a case of a dermoid cyst of conjunctival origin that was attached to the tarsus in a pediatric patient. A 2-year-old bo ... Full text Link to item Cite

Primary Conjunctival Rhabdomyosarcoma Presenting as an Enlarging Papillomatous Lesion in a 3-Year-Old.

Journal Article JAMA Ophthalmol · March 1, 2025 Full text Link to item Cite

Strongyloides stercoralis Choroiditis.

Journal Article JAMA Ophthalmol · January 1, 2025 Full text Link to item Cite

PRIMARY VITREORETINAL LYMPHOMA MASQUERADING AS POSTOPERATIVE ENDOPHTHALMITIS IN A PREGNANT PATIENT WITH LONG-STANDING IDIOPATHIC PANUVEITIS.

Journal Article Retin Cases Brief Rep · July 1, 2024 PURPOSE: To report primary vitreoretinal lymphoma after surgical 0.59 mg fluocinolone acetonide implant (FAi) exchange in a patient treated with adalimumab for idiopathic bilateral panuveitis. METHODS: Retrospective case review. RESULTS: A 37-year-old woma ... Full text Link to item Cite

Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2.

Journal Article J Exp Med · March 4, 2024 Outer retinal degenerations, including age-related macular degeneration (AMD), are characterized by photoreceptor and retinal pigment epithelium (RPE) atrophy. In these blinding diseases, macrophages accumulate at atrophic sites, but their ontogeny and nic ... Full text Link to item Cite

Lasiodiplodia theobromae keratitis: A rare tropical fungal keratitis in a non-tropical climate.

Journal Article Am J Ophthalmol Case Rep · December 2023 PURPOSE: We present the clinical and histopathological findings of a geographically unique Lasiodiplodia theobromae fungal keratitis case in North Carolina. L. theobromae is a rare cause of fungal keratitis, and all but one of the 51 previously reported ca ... Full text Link to item Cite

Eccrine Ductal Carcinoma of the Eyelid.

Journal Article Ophthalmic Plast Reconstr Surg · November 2023 The authors present the third example of an eccrine ductal carcinoma of the eyelid. A woman in her early 70s presented with a lesion of the central right lower eyelid margin in the vicinity where an actinic keratosis was diagnosed by biopsy 2.75 years prev ... Full text Link to item Cite

Green algae keratitis.

Journal Article Can J Ophthalmol · October 2023 Full text Link to item Cite

Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 Interactions.

Journal Article bioRxiv · July 19, 2023 Degenerative diseases of the outer retina, including age-related macular degeneration (AMD), are characterized by atrophy of photoreceptors and retinal pigment epithelium (RPE). In these blinding diseases, macrophages are known to accumulate ectopically at ... Full text Link to item Cite

Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy.

Journal Article JCI Insight · June 22, 2023 Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR and a ... Full text Link to item Cite

A CASE OF HIGH-RISK CILIARY BODY MELANOMA ARISING IN AN EYE AFTER RESECTION OF AN IRIDOCILIARY MELANOCYTOMA.

Journal Article Retin Cases Brief Rep · March 1, 2023 PURPOSE: To report a case of a benign iridociliary melanocytoma recurring as malignant melanoma after excision. METHODS: Observational case report with clinical data, slit-lamp examination findings, ultrasound biomicroscopy results, and histopathological a ... Full text Link to item Cite

Spindle Cell/Sclerosing Rhabdomyosarcoma of the Orbit.

Journal Article Ophthalmic Plast Reconstr Surg · January 2023 A 3-year-old boy developed proptosis over 3 weeks. CT and MRI disclosed a 3.2 × 1.9 cm soft-tissue mass of the right extraconal and intraconal orbit with sphenoid bone erosion. After debulking through an upper eyelid crease incision, the tumor was diagnose ... Full text Open Access Link to item Cite

Molecular Signature of Subretinal Microglia Signifies an Adaptive Response that is Protective in Retinal Degeneration (RD) Mice and is Conserved in Human AMD

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2023 Cite

Histopathological characterization of connective tissue growth factor (CTGF) expression in human eyes with age-related macular degeneration and diabetic retinopathy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2023 Cite

A Pruritic Eyelid Lesion Followed by Conjunctival Swelling.

Journal Article JAMA Ophthalmol · October 1, 2022 Full text Link to item Cite

Error in Figure Caption

Journal Article JAMA Ophthalmology · October 1, 2022 Full text Cite

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.

Journal Article Immunity · September 13, 2022 The apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms remain poorly understood. Here, we found that in two mouse glaucoma models, microglia transitione ... Full text Link to item Cite

Multiple Cranial Neuropathies as the Initial Presentation of Primary Ductal Adenocarcinoma of the Lacrimal Gland.

Journal Article Ophthalmic Plast Reconstr Surg · May 2022 Primary ductal adenocarcinoma of the lacrimal gland is a rare, aggressive malignancy that clinically and histologically resembles salivary duct carcinoma. Similar to other malignant epithelial lacrimal gland tumors, ductal adenocarcinoma typically presents ... Full text Link to item Cite

Mönckeberg sclerosis with giant cells as a masquerade of giant cell arteritis.

Journal Article Eur J Rheumatol · April 2022 Giant cell arteritis (GCA) is the most common type of vasculitis in adults, which is classified as a large/medium vessel vasculitis. It has a predilection for the ophthalmic circulation and extracranial carotid system. Temporal artery biopsy specimens can ... Full text Link to item Cite

Corneal neurotization

Chapter · January 31, 2022 Corneal neurotization is an exciting and powerful means of improving vision in patients with neurotrophic keratitis, although much remains to be clarified about the procedure. The evolution of the procedure and its results are discussed herein. ... Full text Cite

The Role of the STING/Type I IFN Signaling Pathway in Diabetic Retinopathy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

The Role of the STING/Type I IFN Signaling Pathway in Diabetic Retinopathy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

Monocyte Biomarkers of Early-Intermediate Age-Related Macular Degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

A Pruritic Eyelid Lesion Followed by Conjunctival Swelling (vol 140, pg 1017, 2022)

Journal Article JAMA OPHTHALMOLOGY · 2022 Full text Cite

Non-neoplastic Pathology of the Uveal Tract

Chapter · January 1, 2022 The uveal tract is a highly vascular structure consisting of the iris, ciliary body, and choroid. The uveal tract may be involved by developmental abnormalities, noninfectious and infectious inflammation (uveitis), systemic diseases, vascular disorders, de ... Full text Cite

Clinical Reasoning: A 64-Year-Old Man With Multiple Cranial Neuropathies.

Journal Article Neurology · July 13, 2021 Full text Link to item Cite

Uveal Melanoma Metastatic to the Cavernous Sinus: A Case Report.

Journal Article Ophthalmic Plast Reconstr Surg · March 2021 A woman in her early 50s previously treated 7 years prior with iodine-125 plaque brachytherapy without a biopsy for gene expression profiling for uveal melanoma in the left eye presented with a 3-week history of intermittent diplopia and headache. Ophthalm ... Full text Open Access Link to item Cite

Subretinal Mononuclear Cells in Coats' Disease Studied with RPE65 and CD163: Evidence for Histiocytoid Pigment Epithelial Cells.

Journal Article Am J Ophthalmol · February 2021 PURPOSE: To evaluate the mononuclear cells in the subretinal exudate in Coats' disease. DESIGN: Retrospective case series. METHODS: Five enucleated globes and 1 cytology sample from a patient with Coats' disease and 1 case of chronic retinal detachment fol ... Full text Link to item Cite

Markers of Protective Microglia in Mouse Models of Outer Retinal Degeneration Are Present in Human AMD

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2021 Cite

Clinical and Morphologic Outcomes of Minimally Invasive Direct Corneal Neurotization.

Journal Article Ophthalmic Plast Reconstr Surg · 2020 PURPOSE: To describe clinical outcomes of a minimally invasive technique for direct corneal neurotization to treat neurotrophic keratopathy. METHODS: All cases of corneal neurotization for neurotrophic keratopathy performed by a single surgeon using minima ... Full text Link to item Cite

Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.

Journal Article J Neurol · July 2019 Alzheimer's disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in ... Full text Link to item Cite

An Unusual Corneal Mass.

Journal Article JAMA Ophthalmol · June 1, 2019 Full text Link to item Cite

Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014).

Journal Article Biol Blood Marrow Transplant · April 2019 Infections and graft-versus-host disease (GVHD) have historically resulted in high mortality among children undergoing umbilical cord blood transplantation (UCBT). However, recent advances in clinical practice have likely improved outcomes of these patient ... Full text Open Access Link to item Cite

Idiopathic orbital inflammation with bone destruction and extension into the paranasal sinuses.

Journal Article Surv Ophthalmol · 2019 Idiopathic orbital inflammation developed in the right orbit of a woman in her mid-thirties, causing tearing, photophobia, diplopia, altered depth perception, proptosis, and pain on eye movements. Computed tomography disclosed a mass involving the intracon ... Full text Link to item Cite

CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma.

Journal Article Graefes Arch Clin Exp Ophthalmol · December 2018 PURPOSE: Prior research in animal models has shown that macrophages and microglia play an important role in pathogenesis of glaucoma, but the phenotype and distribution of macrophages in human glaucomatous tissue have not been sufficiently characterized. M ... Full text Link to item Cite

Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type.

Journal Article Ocul Oncol Pathol · November 2018 PURPOSE: To report a case of extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type metastatic to the space beneath the retinal pigment epithelium (RPE) with coincident paraneoplastic lymphoma-associated retinopathy. METHODS: Findings of clinical a ... Full text Link to item Cite

Utility of Autopsy among Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: One Last Chance to Learn?

Journal Article Biol Blood Marrow Transplant · September 2018 Autopsy may confirm clinical diagnoses or identify conditions that were not suspected prior to a patient's death. Previous studies evaluating the utility of autopsy in hematopoietic stem cell transplant (HSCT) recipients yielded conflicting results. We con ... Full text Open Access Link to item Cite

Ocular involvement in neurolymphomatosis.

Journal Article Am J Ophthalmol Case Rep · June 2018 PURPOSE: To describe the ophthalmic symptoms and histopathological findings in a case of primary neurolymphomatosis (NL). OBSERVATIONS: A man in his 60s with a prior diagnosis of chronic inflammatory demyelinating polyneuropathy developed facial numbness, ... Full text Link to item Cite

Solitary mastocytoma in the eyelid of an adult.

Journal Article Am J Ophthalmol Case Rep · March 2018 PURPOSE: To describe the ophthalmic symptoms and histopathological findings in a rare case of an eyelid mastocytoma in an adult. OBSERVATIONS: A man in his early 60s developed a painless, non-tender, non-pruritic, mobile nodule on the right lower eyelid be ... Full text Open Access Link to item Cite

Periocular necrotizing fasciitis in an infant.

Journal Article Surv Ophthalmol · 2018 Periocular necrotizing fasciitis developed in a 12-month-old boy with swelling of both eyes and redness and a discharge from the left eye approximately 36 hours after blunt trauma. Computed tomography revealed preseptal and soft-tissue edema on the left si ... Full text Link to item Cite

Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid Associated With Mucinous Adenocarcinoma.

Journal Article Ophthalmic Plast Reconstr Surg · 2018 Endocrine mucin-producing sweat gland carcinoma, a rare, low-grade neoplasm with predilection for the eyelids, has been posited as a precursor to invasive mucinous adenocarcinoma. Endocrine mucin-producing sweat gland carcinoma and its concurrence with muc ... Full text Link to item Cite

Seminoma Metastatic to the Orbit.

Journal Article Ophthalmic Plast Reconstr Surg · 2018 PURPOSE: Seminomas are solid tumors in young men, but which rarely metastasize to the orbit. The authors review the known literature on seminoma metastatic to the orbit, and describe an additional case in a 33-year-old man. METHODS: A literature search was ... Full text Link to item Cite

Adenocarcinoma of Pigmented Ciliary Epithelium in a Child With Aicardi Syndrome and Congenital Microphthalmia With Cyst.

Journal Article Ophthalmic Plast Reconstr Surg · 2018 A 5-year-old girl with Aicardi syndrome and microphthalmia with cyst of the OD presented with progressive enlargement of the cyst causing pain. Microophthalmia with inferior cyst (35 × 25 × 12 mm) was noted at birth, and Aicardi syndrome was diagnosed at 1 ... Full text Link to item Cite

Lacrimal Gland Tumors.

Journal Article Int Ophthalmol Clin · 2018 Full text Link to item Cite

Iris melanin pigment as a masquerade of Gram-positive cocci after penetrating ocular trauma.

Journal Article Digit J Ophthalmol · 2018 We describe a case of penetrating eye injury that resulted in a post-injury day 1 hypopyon, leading to concern for endophthalmitis and phacoanaphylaxis. A Gram stain prepared by the clinical microbiology laboratory was interpreted as Gram-positive cocci (G ... Full text Link to item Cite

Fontana-Masson stain in fungal infections.

Journal Article J Am Acad Dermatol · December 2017 BACKGROUND: Fontana-Masson (FM) staining is a histopathology technique used to identify dematiaceous fungi. The result often guides initial species identification and antifungal treatment; however, there is evidence that nondematiaceous fungi might react w ... Full text Link to item Cite

Pediatric conjunctival melanoma arising from a compound nevus.

Journal Article J AAPOS · October 2017 We present a rare case of conjunctival melanoma in a 9-year-old girl who presented with a conjunctival lesion of the left eye, growth of which was documented by patient photographs. Examination showed a raised pigmented lesion at the temporal limbus, with ... Full text Link to item Cite

Ocular Surface Epithelial Atypia Mimicking Squamous Neoplasia in Association With Ulcerative Colitis.

Journal Article Cornea · April 2017 PURPOSE: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). METHODS: Case re ... Full text Link to item Cite

Ocular histopathology in Eastern equine encephalitis: A case report.

Journal Article Am J Ophthalmol Case Rep · April 2017 PURPOSE: To describe the ophthalmic symptoms and histopathological findings in a human case of Eastern equine encephalitis (EEE). OBSERVATIONS: The patient was a septuagenarian male whose presentation and clinical course were thought to be most consistent ... Full text Link to item Cite

Staying away from the optic nerve: a formula for modifying glaucoma drainage device surgery in pediatric and other small eyes.

Journal Article J AAPOS · February 2017 PURPOSE: To provide guidelines for safe implantation of glaucoma drainage devices (GDDs) in small and pediatric eyes to avoid contact between the optic nerve (ON) and the posterior edge of the GDD plate. METHODS: We developed a formula for calculating limb ... Full text Link to item Cite

"Diagnostic Algorithm for Patients With Suspected Giant Cell Arteritis" Useful, but No Substitute for Thorough Histopathology: Response.

Other J Neuroophthalmol · September 2016 Full text Link to item Cite

Catastrophic antiphospholipid syndrome after cardiac surgery.

Journal Article J Card Surg · September 2016 We report a case of catastrophic antiphospholipid syndrome in a patient following mitral valve replacement. The pathophysiology and management of this rare condition is discussed. ... Full text Link to item Cite

Abundance of CD163+macrophages/microglia in the optic nerves of human post-mortem eyes with glaucoma

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

Identity of pigmented subretinal cells in age-related macular degeneration.

Other Graefes Arch Clin Exp Ophthalmol · June 2016 Full text Link to item Cite

Diagnostic Algorithm for Suspected Giant Cell Arteritis: Response.

Other J Neuroophthalmol · June 2016 Full text Link to item Cite

Clinical-Pathological Correlation of Vogt-Koyanagi-Harada Disease.

Journal Article JAMA Ophthalmol · March 2016 Full text Link to item Cite

Keratomalacia in a Patient With Psychogenic Vitamin A Deficiency.

Journal Article Cornea · March 2016 PURPOSE: To report the clinical and histopathological findings of a patient with bilateral keratomalacia arising from severe vitamin A deficiency from panic disorder-related malnutrition. METHODS: Case report. RESULTS: A 47-year-old male with panic disorde ... Full text Link to item Cite

Formation of Macular Inner Nuclear Layer Cysts in Optic Atrophy.

Other Invest Ophthalmol Vis Sci · March 2016 Full text Link to item Cite

Primary adenocarcinoma of pigmented ciliary epithelium in a phthisical eye.

Journal Article Surv Ophthalmol · 2016 We report a case of adenocarcinoma of the pigmented ciliary epithelium arising in a phthisical eye. A 92-year-old man who initially presented with severe ocular pain had calcification extending from the posterior pole to ciliary body on B-scan ultrasonogra ... Full text Link to item Cite

So-called massive retinal gliosis: A critical review and reappraisal.

Journal Article Surv Ophthalmol · 2016 Massive retinal gliosis, a nonneoplastic retinal glial proliferation, was first described in detail over 25 years ago, before the era of immunohistochemistry, in a series of 38 cases-to which can be added 30 case reports or small series (no more than 3 cas ... Full text Link to item Cite

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities.

Journal Article Neuropathology · December 2015 Intraocular medulloepithelioma (IO MEPL) is an uncommon embryonal neuroepithelial neoplasm of the eye. These ocular neoplasms have been compared with intracranial medulloepitheliomas or other histologic variants of CNS embryonal tumor with multilayered ros ... Full text Link to item Cite

Atypical Fibroxanthoma of the Bulbar Conjunctiva.

Journal Article Cornea · December 2015 PURPOSE: To report a rare case of atypical fibroxanthoma (AFX) of the bulbar conjunctiva, and to compare it with previously published cases of conjunctival AFX. METHODS: A 37-year-old woman developed a growth on the bulbar conjunctiva of her left eye that ... Full text Open Access Link to item Cite

Abundance of infiltrating CD163+ cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration.

Journal Article Graefes Arch Clin Exp Ophthalmol · November 2015 PURPOSE: Prior research in animal models has suggested that retinal macrophages play an important role in age-related macular degeneration (AMD), but studies have insufficiently characterized the distribution of retinal macrophages in various stages of hum ... Full text Link to item Cite

Diagnostic Algorithm for Patients With Suspected Giant Cell Arteritis.

Journal Article J Neuroophthalmol · September 2015 BACKGROUND: To identify clinical and laboratory factors contributing to the diagnosis of giant cell arteritis (GCA) and develop a diagnostic algorithm for the evaluation of GCA. METHODS: Retrospective review of 213 consecutive cases of temporal artery biop ... Full text Link to item Cite

Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC.

Journal Article Am J Ophthalmol · June 2015 PURPOSE: To compare immunohistochemical and genetic overlaps and differences between intraocular medulloepitheliomas and embryonal tumors with multilayered rosettes of the brain. DESIGN: Retrospective histopathologic, immunohistochemical, and genetic analy ... Full text Link to item Cite

Retinal Macrophages in Stages of Age-related Macular Degeneration

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.

Journal Article Am J Pathol · February 2015 Ocular hypertension arising from increased resistance to aqueous humor (AH) outflow through the trabecular meshwork is a primary risk factor for open-angle glaucoma, a leading cause of blindness. Ongoing efforts have found little about the molecular and ce ... Full text Link to item Cite

Postmortem Findings and Clinical Correlates in Individuals with Infantile-Onset Pompe Disease.

Journal Article JIMD Rep · 2015 Pompe disease (OMIM 232300), a glycogen storage disorder caused by deficiency in the lysosomal enzyme acid alpha-glucosidase (EC 3.2.1.20), results in weakness and cardiomyopathy in infants affected with the classic form. Although the primary disease manif ... Full text Link to item Cite

Erratum

Journal Article Cornea · January 2015 Full text Cite

Atypical lymphocytic angiitis of the optic nerve and central nervous system.

Journal Article JAMA Ophthalmol · November 2014 Full text Link to item Cite

Clinical course and origin of epithelium in cases of epithelial downgrowth after Descemet stripping automated endothelial keratoplasty.

Journal Article Cornea · November 2014 PURPOSE: The aim of this study was to report a case series of epithelial downgrowth associated with Descemet stripping automated endothelial keratoplasty (DSAEK) and to explore the origin of the anterior chamber corneal epithelium. METHODS: This is a case ... Full text Link to item Cite

Development of bilateral acquired toxoplasmic retinochoroiditis during erlotinib therapy.

Journal Article JAMA Ophthalmol · September 2014 Full text Link to item Cite

RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction.

Journal Article J Clin Invest · May 2014 Respiratory syncytial virus (RSV) infection is the major cause of bronchiolitis in young children. The factors that contribute to the increased propensity of RSV-induced distal airway disease compared with other commonly encountered respiratory viruses rem ... Full text Link to item Cite

Ocular and histologic findings in a series of children with infantile pompe disease treated with enzyme replacement therapy.

Journal Article J Pediatr Ophthalmol Strabismus · 2014 PURPOSE: To report the ophthalmologic and histologic findings in a series of children with infantile Pompe disease treated with enzyme replacement therapy (ERT). METHODS: Records of children with infantile Pompe disease treated with ERT who had at least on ... Full text Link to item Cite

An Epstein-Barr virus-positive diffuse large B-cell lymphoma presenting as multi-organ failure: a catastrophic lymphomatosis with fulminant visceral organ dissemination resulting in a precipitous death in a 59-year-old female with no identifiable etiology for immunodeficiency.

Journal Article Pathol Res Pract · January 2014 Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (EBV+ DLBCL) of the elderly is an aggressive B-cell neoplasm related to age-associated impaired immunity. We report such a case in a 59-year-old woman with a catastrophic disease course. The p ... Full text Link to item Cite

Late-onset melanopenic hypomelanosis as a complication of cosmetic eyeliner tattoo.

Other J Am Acad Dermatol · September 2013 Full text Link to item Cite

Clinically undiagnosed enteropathy associated T-cell lymphoma type II presenting with prolonged lower gastrointestinal tract symptoms: report of an autopsy case and review of diagnostic challenges and clinicopathological correlation.

Journal Article J Gastrointest Oncol · March 2013 An elderly patient with watery diarrhea for 3 months received extensive laboratory, radiographic and upper and lower gastrointestinal (GI) endoscopic work up including colonic biopsies, but a diagnosis was not established before death. At autopsy enteropat ... Full text Link to item Cite

Distinct, bilateral epithelioid hemangioma of the orbit.

Journal Article Orbit · February 2013 UNLABELLED: ABSTRACT Introduction: Epithelioid hemangioma (EH) is a benign abnormal proliferation of endothelial cells usually arising in the head and neck region and presenting clinically as raised cutaneous lesions. EH rarely involves the orbit and has n ... Full text Link to item Cite

CARDIAC PATHOLOGY AND CLINICAL FINDINGS COMPARISON IN PATIENTS AND DOGS WITH GLYCOGEN STORAGE DISEASE TYPE III

Conference JOURNAL OF INHERITED METABOLIC DISEASE · September 1, 2012 Link to item Cite

Autopsy findings in late-onset Pompe disease: a case report and systematic review of the literature.

Journal Article Mol Genet Metab · August 2012 BACKGROUND: Late-onset Pompe disease (LOPD) is a rare cause of declining proximal muscle strength and respiratory function that can also affect other organ systems. The development of enzyme replacement therapy has made it one of the few inherited muscle d ... Full text Link to item Cite

Primary Signet-Ring/Histiocytoid Carcinoma of the Eyelid

Conference LABORATORY INVESTIGATION · February 1, 2012 Link to item Cite

Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma.

Journal Article J Glaucoma · 2012 PURPOSE: To determine changes in the expression profile of RhoA and Rho kinase (ROCK-1 and ROCK-2) in the aqueous humor outflow pathway and optic nerve head (ONH) of human eyes with or without glaucoma to explore their potential involvement in glaucoma pat ... Full text Link to item Cite

Epithelioid hemangioma responsive to oral propranolol.

Journal Article Ophthalmic Plast Reconstr Surg · 2012 An 11-year-old boy presented with progressive right-sided proptosis and an orbital mass on neuroimaging. Incisional biopsy revealed an epithelioid hemangioma. The patient underwent an orbitotomy with subtotal excision of the mass. However, the tumor recurr ... Full text Link to item Cite

Primary Signet-Ring/Histiocytoid Carcinoma of the Eyelid

Conference MODERN PATHOLOGY · 2012 Cite

Cardiac Pathology in Glycogen Storage Disease Type III.

Journal Article JIMD Rep · 2012 PURPOSE: To investigate the distribution and clinical impact of glycogen accumulation on heart structure and function in individuals with GSD III. METHODS: We examined cardiac tissue and the clinical records of three individuals with GSD IIIa who died or u ... Full text Link to item Cite

Hematolymphoid malignancies with intraocular intravascular involvement: report of 2 cases.

Journal Article Ann Diagn Pathol · August 2011 The interaction between the endothelium and malignant hematolymphoid cells within vessels of the eye can result in focal or diffuse intravascular pathology. As a result, correlation of these findings with specific clinical and ophthalmologic features can v ... Full text Link to item Cite

Lesions of the lacrimal caruncle with an emphasis on oncocytoma.

Journal Article Am J Dermatopathol · May 2011 Lesions of the lacrimal caruncle vary widely due to its unique composition. Rarely, dermatologists and dermatopathologists encounter biopsies taken from this location. The aims of this study were to (1) retrospectively review caruncular lesions of the eye ... Full text Link to item Cite

Granulomatous choroiditis in Wegener granulomatosis.

Journal Article Arch Ophthalmol · April 2011 Full text Link to item Cite

Cutaneous lupus erythematosus of the eyelid as a mimic of squamous epithelial malignancies: a clinicopathologic study of 9 cases.

Journal Article Ophthalmic Plast Reconstr Surg · 2011 PURPOSE: To describe 9 cases of chronic cutaneous lupus of the eyelid, its potential similarities with squamous epithelial malignancies, and clinical and histopathologic features that assist in distinguishing lupus from epidermal neoplasia. METHODS: The au ... Full text Link to item Cite

A unique case of unilateral synophthalmia.

Journal Article Pediatr Dev Pathol · 2011 Developmental anomalies resulting in a single eye (cyclopia) or fusion of the eyes (synophthalmia) are rare. Examples of unilateral synophthalmia-in which there are 1 normal and 2 fused eyes from 3 anlagen in 2 orbits, 1 lateral proboscis, and 3 optic nerv ... Full text Link to item Cite

The effect of alpha1-adrenergic receptor antagonist tamsulosin (Flomax) on iris dilator smooth muscle anatomy.

Journal Article Ophthalmology · September 2010 PURPOSE: To characterize and determine the effect of tamsulosin (Flomax) on the human iris dilator muscle anatomy. DESIGN: Retrospective, case-control study. PARTICIPANTS: This study comprised 51 cadaveric eyes from 27 patients (14 with a history of tamsul ... Full text Link to item Cite

Primary mucinous carcinoma of the eyelid: a clinicopathologic and immunohistochemical study of 4 cases and an update on recurrence rates.

Journal Article Arch Ophthalmol · September 2010 OBJECTIVES: To report 4 cases of primary mucinous carcinoma of the eyelid, demonstrate how p63 expression aids diagnosis, and review the literature regarding the local recurrence potential of these eyelid tumors. METHODS: Since 1991, we have examined 4 cas ... Full text Link to item Cite

Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration.

Journal Article Invest Ophthalmol Vis Sci · August 2010 Featured Publication PURPOSE: To analyze serum cytokine levels in subjects with different stages of AMD and to study the expression of salient cytokines in postmortem eyes with AMD. METHODS: A suspension array system was used to analyze sera (n = 18 to 20/group) from control s ... Full text Link to item Cite

Neurothekeoma palpebrae: A report of 3 cases.

Journal Article Am J Dermatopathol · June 2010 Neurothekeoma palpebrae is the diagnostic term used to describe nerve sheath myxoma or neurothekeoma of the eyelid. Although these tumors are not uncommonly found in the head and neck region, eyelid involvement is very uncommon. We present 2 cases of cellu ... Full text Link to item Cite

Elevated Levels of RhoA in the Optic Nerve Head of Human Eyes With Glaucoma

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2010 Link to item Cite

Mixed tumor of the choroid.

Journal Article Arch Ophthalmol · March 2010 Featured Publication Full text Link to item Cite

Intraretinal neovascularization in diabetic retinopathy.

Journal Article Arch Ophthalmol · January 2010 Featured Publication Full text Link to item Cite

Clinical and histologic ocular findings in pompe disease.

Journal Article J Pediatr Ophthalmol Strabismus · 2010 PURPOSE: Limited information is available on the ocular findings in patients with Pompe disease. METHOD: This study summarizes this information with a systematic literature review; reports the ocular histologic findings seen in a deceased infant with Pompe ... Full text Link to item Cite

The histology of graft adhesion in descemet stripping with endothelial keratoplasty.

Journal Article Am J Ophthalmol · August 2009 Featured Publication PURPOSE: To describe the histologic findings of full-thickness corneas from penetrating keratoplasty (PK) in 10 patients with a prior history of Descemet stripping with endothelial keratoplasty. DESIGN: Retrospective review of the histopathology of 10 PK s ... Full text Link to item Cite

Comparison of sutures and dendritic polymer adhesives for corneal laceration repair in an in vivo chicken model.

Journal Article Arch Ophthalmol · April 2009 Featured Publication OBJECTIVE: To compare clinical and histologic healing of corneal lacerations repaired by sutures or a new polymeric adhesive. METHODS: A central full-thickness 4.1-mm laceration was made in the right eyes of 60 white leghorn chickens. Half of the wounds we ... Full text Link to item Cite

A previously unreported complication of apicoaortic conduit for severe aortic stenosis.

Journal Article Ann Thorac Surg · March 2009 Featured Publication Given the aging population, use of an apicoaortic conduit serves as an alternative method to treat severe aortic stenosis, especially in patients with a heavily calcified ascending aorta or prior cardiac surgery. Although an apicoaortic conduit fractionate ... Full text Link to item Cite

Candida glabrata endophthalmitis following penetrating keratoplasty.

Journal Article J Cataract Refract Surg · March 2009 Featured Publication We report a case of Candida glabrata endophthalmitis following penetrating keratoplasty in a 57-year-old man. The infection was thought to be treated successfully with intravitreal amphotericin B but flared 7 months later following cataract extraction and ... Full text Link to item Cite

The Duke Uterine Fibroid Tissue Repository - A Stepping Stone for Translational Research

Conference REPRODUCTIVE SCIENCES · March 1, 2009 Link to item Cite

Acne agminata limited to the eyelids.

Journal Article Ophthalmic Plast Reconstr Surg · 2009 Featured Publication A 45-year-old woman had a 1-year history of multiple small papules on both upper eyelids that waxed and waned in size and disappeared in the vicinity of a steroid injection site. Acne agminata (lupus miliaris disseminatus faciei, acnitis, papular tuberculi ... Full text Link to item Cite

Translocations and amplifications of chromosome 12 in liposarcoma demonstrated by the LSI CHOP breakapart rearrangement probe.

Journal Article Arch Pathol Lab Med · June 2008 CONTEXT: Liposarcomas display a number of molecular abnormalities involving chromosome 12. Myxoid and round cell liposarcomas are characterized by t(12;16)(q13; p11) or t(12;22)(q13;q12) translocations. Amplifications occur within the 12q13-15 region of at ... Full text Link to item Cite

Viral disease

Chapter · January 1, 2008 Ocular viral infections are a particularly complex topic for diagnosticians and clinicians alike. The eye’s component parts, though packed into a space measuring approximately one inch in diameter, are rich in diversity and varied in embryonic origin, invi ... Cite

Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome?

Journal Article Anesth Analg · January 2008 Featured Publication BACKGROUND: Perfluorocarbon (PFC) emulsions are artificial oxygen carriers that have been shown to attenuate the effects of air embolism. Cerebral air embolism, known to occur during cardiopulmonary bypass (CPB), may contribute to adverse cerebral outcomes ... Full text Link to item Cite

Striated muscle hamartoma of the eyelid in an adult woman.

Journal Article Ophthalmic Plast Reconstr Surg · 2008 Featured Publication A 57-year-old woman presented with a recurrent lower eyelid growth that was found to be a striated muscle hamartoma on surgical biopsy. This is a rare entity in adults with no history of congenital abnormality. Several other rare, benign lesions may be cli ... Full text Link to item Cite

Designing the "next generation" of medical information systems

Journal Article Proceedings 9th International Conference on Information Technology Icit 2006 · November 16, 2007 A new breed of medical information systems is required to more effectively address unresolved and newly emerging needs in the healthcare environment. This paper attempts to define those needs and describe the design and implementation of a solution. In ord ... Full text Cite

Viral disease

Chapter · November 1, 2007 Cite

Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.

Journal Article J Cutan Pathol · November 2007 Featured Publication AIM: Adnexal tumors with divergent lines of differentiation are uncommon. Herein, I report a hamartoma of the eyelid with follicular, sebaceous and apocrine differentiation that exhibited prominent melanin pigmentation. METHODS: A 63-year-old white woman h ... Full text Link to item Cite

Glycogen storage diseases

Chapter · January 1, 2007 Glycogen is the storage form of glucose in virtually all animal cells, but it is most abundant in liver and muscle (7,15,31). Glycogen is a highly branched polymer with a treelike structure that can accommodate up to 60,000 glucose units in a single globul ... Cite

Diagnostic Atlas of Common Eyelid Diseases

Book · January 1, 2007 Unlike any other source on the subject, this broad-ranging guide discusses the pathology, diagnosis, and treatment of 120 eyelid disorders including benign lesions, malignant tumors, and acquired and congenital malpositions and diseases. Written by leading ... Full text Cite

Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole.

Journal Article J Clin Oncol · July 1, 2006 Featured Publication PURPOSE: To investigate the impact of human epidermal growth factor receptor (HER) 1 and HER2 gene amplification on endocrine therapy responsiveness, a fluorescence in situ hybridization (FISH) study was conducted on tumor samples from 305 postmenopausal p ... Full text Link to item Cite

Recombinant tissue plasminogen activator injected into the vitreous cavity may penetrate the retinal veins of a porcine model of vascular occlusion.

Journal Article Br J Ophthalmol · July 2006 Featured Publication AIM: To determine if recombinant tissue plasminogen activator (rtPA) injected into the vitreous cavity can penetrate the retinal vessels of porcine eyes with or without vascular occlusion. METHODS: Eight eyes (group I) of four pigs underwent clamping of th ... Full text Link to item Cite

262: KI-67: A Potential Prognostic Biomarker for PSA Recurrence?

Conference Journal of Urology · April 2006 Full text Cite

Basal cell-signet-ring squamous cell carcinoma of the eyelid.

Journal Article Arch Pathol Lab Med · March 2006 Featured Publication A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fl ... Full text Link to item Cite

Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism.

Journal Article Cardiovasc Res · March 1, 2006 OBJECTIVE: Studies have reported that administration of stromal cell-derived factor-1 (SDF-1), the ligand for the G-protein coupled receptor CXCR4, increased collateral blood flow in a mouse model of vascular insufficiency via recruitment of endothelial pr ... Full text Link to item Cite

Fibrovascular ingrowth as a cause of Ahmed glaucoma valve failure in children.

Journal Article Am J Ophthalmol · February 2006 Featured Publication PURPOSE: The purpose of this study is to document the presence of fibrovascular ingrowth into the Ahmed glaucoma valve (AGV) as a cause of AGV failure in the pediatric population. DESIGN: Retrospective case series. METHODS: Retrospective study of six child ... Full text Link to item Cite

Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome?

Journal Article Journal of Neurosurgical Anesthesiology · January 1, 2006 Full text Cite

Dermoid cyst of conjunctival origin.

Journal Article Ophthalmic Plast Reconstr Surg · 2006 Featured Publication A 22-year-old man with a recurrent intraconal cystic mass of the orbit presented with proptosis, motility restriction, and optic disc edema. On initial surgery, the cyst wall showed nonkeratinized cuboidal epithelium with adnexal structures. After recurren ... Full text Link to item Cite

Basal-like cells constitute the proliferating cell population in cystic fibrosis airways.

Journal Article Am J Respir Crit Care Med · October 15, 2005 Featured Publication RATIONALE: Cystic fibrosis airways are recurrently exposed to noxious stimuli, leading to epithelial injury. Previous reports suggest that cystic fibrosis airway epithelia may respond to injury by increasing proliferation. OBJECTIVES: We sought to determin ... Full text Link to item Cite

Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity.

Journal Article Leuk Lymphoma · October 2005 Featured Publication This study investigated stromal changes in expression of tenascin and vasculogenesis in lymphoma. Documenting the dynamic nature of the stromal changes in lymphoma in relation to response to therapy is helpful in planning new therapies directed at these ta ... Full text Link to item Cite

Collagen-rich crystalloids in a scarred vascularized cornea.

Journal Article Arch Pathol Lab Med · September 2005 Featured Publication Collagen-rich crystalloids, also referred to as collagenous crystalloids, are uncommon findings in benign salivary gland tumors with myoepithelial differentiation and in cutaneous neoplasms. Herein, we report the presence of collagen-rich crystalloids in t ... Full text Link to item Cite

Epithelioid hemangioma of the orbit

Journal Article Clinical and Surgical Ophthalmology · August 1, 2004 A 69-year-old African-American woman presented to the Duke University Eye Center with chief complaints of progressive swelling, occasional sharp pains, and a tender knot in the superomedial aspect of her right orbit for nine months. She denied fever and an ... Cite

HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors.

Journal Article Clin Cancer Res · June 15, 2004 PURPOSE: This study investigated the connection among HER-2 gene amplification, HER-2 protein expression, and markers of tumor angiogenesis and oxygenation in patients with operable, invasive breast tumors. EXPERIMENTAL DESIGN: From 1988 to 1995, 425 patie ... Full text Link to item Cite

A new paradigm for corneal wound healing research: the white leghorn chicken (Gallus gallus domesticus).

Journal Article Curr Eye Res · April 2004 PURPOSE: To evaluate the chicken cornea as a model for corneal wound healing research. METHODS: We conducted studies on normal chicken corneas and on corneas following mechanical debridement and photorefractive keratectomy (PRK). RESULTS: The chicken corne ... Full text Link to item Cite

PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity.

Journal Article Am J Physiol Renal Physiol · March 2004 Previous studies demonstrated that during cisplatin-induced acute renal failure, there is a significant reduction in proximal tubule fatty acid oxidation. We now report on the effects of peroxisome proliferator-activated receptor-alpha (PPAR alpha) ligand ... Full text Link to item Cite

Optic nerve compression in infantile malignant autosomal recessive osteopetrosis.

Journal Article J Pediatr Ophthalmol Strabismus · 2004 A 6-month-old infant was diagnosed with infantile malignant autosomal recessive osteopetrosis. An ophthalmologic examination revealed optic nerve pallor and computed tomography of the brain showed narrowing of the orbital fissure. Unrelated umbilical cord ... Full text Link to item Cite

Proteome analysis of the rat cornea during angiogenesis.

Journal Article Proteomics · November 2003 Angiogenesis is the formation of new blood vessels from the pre-existing vasculature. However, the study of this complex process is often hampered by the lack of a suitable cell-based model and the tools to study the biochemical events that lead to new blo ... Full text Link to item Cite

Recommendations for the reporting of tissues removed as part of the surgical treatment of common malignancies of the eye and its adnexa.

Journal Article Mod Pathol · July 2003 The Association of Directors of Anatomic and Surgical Pathology developed recommendations for the surgical pathology report for common malignant tumors. The recommendations for tumors of the eye and its adnexa are reported. ... Full text Link to item Cite

Recommendations for the reporting of tissues removed as part of the surgical treatment of common malignancies of the eye and its adnexa.

Journal Article Am J Surg Pathol · July 2003 The Association of Directors of Anatomic and Surgical Pathology developed recommendations for the surgical pathology report for common malignant tumors. The recommendations for tumors of the eye and its adnexa are reported. ... Full text Link to item Cite

Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA.

Journal Article Cancer Invest · June 2003 Immunizations with dendritic cells (DC) transfected with RNA encoding tumor antigens induce potent tumor antigen-specific immune responses in vitro and in murine models. We performed a phase I study of patients with advanced carcinoembryonic antigen (CEA)- ... Full text Link to item Cite

Corneal reepithelialization rates following application of bandage contact lens and eye lid tarsorraphy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2003 Link to item Cite

Recommendations for the reporting of tissues removed as part of the surgical treatment of common malignancies of the eye and its adnexa. The Association of Directors of Anatomic and Surgical Pathology.

Journal Article Hum Pathol · February 2003 Full text Link to item Cite

Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor.

Journal Article Clin Cancer Res · February 2003 PURPOSE: The purpose of this study was to evaluate the feasibility of incorporating a novel wound angiogenesis assay into a Phase I study of BMS-275291, a broad-spectrum matrix metalloproteinase inhibitor, and to determine whether the wound angiogenesis as ... Link to item Cite

Recommendations for the reporting of tissues removed as part of the surgical treatment of common malignancies of the eye and its adnexa.

Journal Article Am J Clin Pathol · February 2003 Full text Link to item Cite

A clinical model of dermal wound angiogenesis.

Journal Article Wound Repair Regen · 2003 Full-thickness dermal biopsies were performed in healthy volunteers to establish the range of angiogenic responses in wound healing in a normal population. Four-millimeter punch biopsies were made in the forearms of 15 healthy volunteers. Each wound was ev ... Full text Link to item Cite

Interlaboratory variation in results from immunohistochemical assessment of estrogen receptor status.

Journal Article Breast J · 2003 Full text Link to item Cite

Bilateral diffuse uveal melanocytic proliferation associated with pancreatic carcinoma: a case report and literature review of this paraneoplastic syndrome.

Journal Article Surv Ophthalmol · 2003 A case of a 64-year-old man with bilateral diffuse uveal melanocytic proliferation is presented. Bilateral diffuse uveal melanocytic proliferation is a rare paraneoplastic disorder where an underlying malignancy causes bilateral blindness by uveal thickeni ... Full text Link to item Cite

The CLN3 gene is a novel molecular target for cancer drug discovery.

Journal Article Cancer Res · February 1, 2002 Juvenile Batten disease is a neurodegenerative disease caused by accelerated apoptotic death of photoreceptors and neurons attributable to defects in the CLN3 gene. CLN3 is antiapoptotic when overexpressed in NT2 neuronal precursor cells. CLN3 negatively m ... Link to item Cite

Histopathology of graves’ orbital disease

Chapter · January 1, 2002 The histopathology of Graves’ orbital disease has been studied extensively over many decades. The bulk of evidence indicates that the extraocular muscles are the primary site of immunological attack and the resulting myositis causes the exophthalmos noted ... Full text Cite

The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer.

Journal Article Int J Gastrointest Cancer · 2002 BACKGROUND: Resected pancreatic cancer has a high risk of recurrence and mortality despite the the use of chemoradiotherapy. Because pancreatic cancers express tumor antigens such as carcinoembryonic antigen (CEA), it may be possible to immunize patients t ... Full text Link to item Cite

Fulminant hepatic failure due to disseminated adenovirus infection in a patient with chronic lymphocytic leukemia.

Journal Article Cancer Control · 2002 Full text Link to item Cite

Epibulbar osseous choristoma: case report and review of the literature.

Journal Article Ophthalmic Surg Lasers · 2002 Epibulbar osseous choristoma is a choristomatous lesion of the conjunctiva containing bone. Originally called epibulbar osteoma, this lesion was first described by von Graefe in 1863. We discuss a case of a 4-year-old patient who presented with an epibulba ... Link to item Cite

Wound angiogenesis in healthy volunteers using OPSI technology: A potential surrogate marker for antiangiogenesis agents.

Other CLINICAL CANCER RESEARCH · November 1, 2001 Link to item Cite

Unexpected autopsy findings arising from postmortem ocular examination.

Journal Article Arch Pathol Lab Med · September 2001 BACKGROUND: A full autopsy at our institution includes removal of the eyes for pathologic examination. To our knowledge, the rate of ophthalmic findings at autopsy has not been documented previously. DESIGN: We retrospectively reviewed 277 consecutive auto ... Full text Link to item Cite

Type III collagen deposition in the chicken cornea following laser keratectomy.

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2001 Link to item Cite

Corneal wound healing in the anterior stroma following thin LASIK flap formation.

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2001 Link to item Cite

Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer.

Journal Article J Clin Oncol · December 1, 2000 PURPOSE: To evaluate preoperative dendritic cell (DC) mobilization and tumor infiltration after administration of Flt3 ligand (Flt3L) to patients with metastatic colon cancer. PATIENTS AND METHODS: Twelve patients with colon cancer metastatic to the liver ... Full text Link to item Cite

8(S)-hydroxyeicosatetraenoic acid is the lipoxygenase metabolite of arachidonic acid that regulates epithelial cell migration in the rat cornea.

Journal Article Cornea · May 2000 BACKGROUND: We previously found that the inhibition of lipoxygenases resulted in delayed epithelial wound closure in organ-cultured rat corneas. The present study was undertaken to determine the lipoxygenase enzyme and metabolite(s) responsible for regulat ... Full text Link to item Cite

Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure.

Journal Article Am J Physiol Renal Physiol · April 2000 Regulation of fatty acid beta-oxidation (FAO) represents an important mechanism for a sustained balance of energy production/utilization in kidney tissue. To examine the role of stimulated FAO during ischemia, Etomoxir (Eto), clofibrate, and WY-14,643 comp ... Full text Link to item Cite

An animal model for LASIK flap research: The White Leghorn chicken.

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2000 Link to item Cite

A comparative study of bovine pericardium (periguard) and homologous sclera as lower eyelid spacer graft analogs in New Zealand white rabbits.

Journal Article Ophthalmic Plast Reconstr Surg · March 2000 PURPOSE: To compare bovine pericardium (Periguard; Bio-Vascular, Inc., St. Paul, MN, U.S.A.) and homologous sclera as spacer graft analogs in a rabbit model. METHODS: A nonrandomized experimental animal study was conducted. Elliptical subconjunctival impla ... Full text Link to item Cite

Markers of angiogenesis, factor VIII and tenascin, correlate with disease activity in patients with Non-Hodgkin's Lymphoma.

Journal Article BLOOD · November 15, 1999 Link to item Cite

The influence of hyperbaric oxygen therapy and irradiation on hydroxyapatite ocular implant exposure and fibrovascular ingrowth in New Zealand white rabbits.

Journal Article Ophthalmic Plast Reconstr Surg · November 1999 PURPOSE: Lack of adequate fibrovascular ingrowth has been implicated as a cause of exposure of hydroxyapatite (HA) implants in anophthalmic sockets. We investigated the vasculopathic effects of external beam irradiation, and the fibrovascular-enhancement e ... Full text Link to item Cite

Bovine pericardium versus homologous sclera as wrapping materials for hydroxyapatite ocular implants: an animal study.

Journal Article Ophthalmic Plast Reconstr Surg · September 1999 PURPOSE: We compared bovine pericardium and homologous sclera as wrapping materials for hydroxyapatite (HA) ocular implants in enucleated New Zealand white rabbits. METHODS: Eighteen rabbits were unilaterally enucleated and the sockets implanted with 10-mm ... Full text Link to item Cite

Systematic infrared ablations with the mark III FEL at 2.94 μm in the chicken cornea

Journal Article Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment · January 1, 1999 Introduction. Previous studies with the free electron laser have only assessed the corneal tissue response in ex vivo models. This is the first free electron laser investigation that has examined the clinical and histologic response of the cornea in vivo. ... Full text Cite

Free electron laser: A system capable of determining the gold standard in laser vision correction

Journal Article Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment · January 1, 1999 Introduction. In laser vision correction surgery, lasers are generally utilized based on their beam-tissue interactions and corneal absorption characteristics. Therefore, the free electron laser, with its ability to provide broad wavelength tunability, is ... Full text Cite

Rate of vascularization of coralline hydroxyapatite spherical implants pretreated with saline/gentamicin, rTGF-beta 2, and autogenous plasma.

Journal Article Ophthalmic Plast Reconstr Surg · March 1998 Several authors have reported significant exposure rates using the hydroxyapatite orbital implant in the treatment of the anophthalmic socket. Histologic studies by ourselves and others have suggested that lack of fibrovascular ingrowth into the implants m ... Full text Link to item Cite

Clinicopathologic features and surgical management of dissecting glaucoma filtering blebs.

Journal Article Ophthalmic Surg Lasers · February 1997 Three patients are described in whom full-thickness glaucoma filtering procedures were complicated by marked extension of the bleb over the cornea, with subsequent symptoms that required surgical intervention. The surgical management in each case involved ... Link to item Cite

Ocular metastasis as the initial presentation of esophageal carcinoma.

Journal Article Can J Ophthalmol · February 1997 Link to item Cite

Transmission electron (TEM) and Light Microscopic (LM) analysis of hyperopic and myopic corrections induced by a photosensitizing dye and the argon laser in a rabbit model

Journal Article Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: To study the histopathologic effects and possible collagen fiber alterations in rabbits previously shown to exhibit refractive change by treatment with a photoactivated chromophore and the argon laser while maintaining clear corneas. Methods: Two ... Cite

Systematic free electron laser delivery of mid-infrared wavelengths to porcine corneas: Histologic analysis

Journal Article Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: To evaluate histologically the ablative properties of the mid-infrared range of wavelengths on corneal tissue, with specific regard to dimensions of ablation and extent of collateral damage. Methods: Free electron laser (FEL) generated wavelengths ... Cite

Transmission electron (TEM) and light microscopic (LM) analysis of hyperopic and myopic corrections induced by a photosensitizing dye and the argon laser in a rabbit model

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · February 15, 1996 Link to item Cite

Systematic free electron laser delivery of mid-infrared wavelengths to porcine corneas: Histologic analysis

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · February 15, 1996 Link to item Cite

Cytomegalovirus keratitis after penetrating keratoplasty.

Journal Article Cornea · November 1995 We report the development of cytomegalovirus (CMV) keratitis in the penetrating keratoplasty of a 59-year-old human immunodeficiency virus-negative woman after uncomplicated corneal transplantation. Immunosuppression with topical cyclosporine A 2% in corn ... Link to item Cite

Coordinated activation of corneal wound response genes in vivo as observed by in situ hybridization.

Journal Article Exp Eye Res · October 1995 We used subtractive screening of a cDNA library prepared from corneoscleral rims after cauterizing rat corneas. We identified 76 clones whose corresponding mRNA increased during the wound healing process in an in vivo model of injury which damages the corn ... Full text Link to item Cite

8-HETE IS THE LIPOXYGENASE METABOLITE OF ARACHIDONIC-ACID WHICH REGULATES CORNEAL EPITHELIAL WOUND-HEALING IN THE RAT

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1995 Link to item Cite

METABOLISM OF [H-3] LINOLEIC-ACID TO 13-HYDROXY-9,11-OCTADECADIENOIC ACID (13-HODE) BY RAT CORNEA

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1995 Link to item Cite

LENS EPITHELIAL HYPERPLASIA WITH NEW CAPSULAR FORMATION - POTENTIAL FOR OUTGROWTH OR REPAIR

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1995 Link to item Cite

Removal of optic disc stalks during diabetic vitrectomy.

Journal Article Retina · 1995 BACKGROUND: The morphologic features and clinical consequences of removing residual optic disc stalks during vitrectomy for complications of diabetic retinopathy have not been described. METHODS: Twenty-four residual optic disc stalks that were surgically ... Full text Link to item Cite

Pyogenic granuloma of the cornea induced by "snake oil".

Journal Article Cornea · May 1994 A pyogenic granuloma of the cornea developed on the vascularized cornea of a 79-year-old woman after "snake oil" accidentally dripped in her eye. The snake oil was being used to relieve forehead pain, which may have been referred. The five previously repor ... Full text Link to item Cite

A TISSUE-CULTURE ASSAY OF RAT CORNEAL EPITHELIAL WOUND CLOSURE

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1994 Link to item Cite

The effect of angiostatic steroids and beta-cyclodextrin tetradecasulfate on corneal neovascularization in the rat.

Journal Article Exp Eye Res · December 1993 Folkman and coworkers have described angiostatic steroids that markedly inhibit neovascularization of the rabbit cornea when given topically with beta-cyclodextrin tetradecasulfate (beta-CD), yet have minimal or no glucocorticoid or mineralocorticoid activ ... Full text Link to item Cite

The effect of prostaglandin E2 on corneal inflammation in the rat.

Journal Article Exp Eye Res · October 1993 Full text Link to item Cite

Effect of inhibitors of arachidonic acid metabolism on corneal reepithelialization in the rat.

Journal Article Exp Eye Res · June 1993 We examined the ability of inhibitors of arachidonic acid metabolism to influence the rate of healing of organ-cultured rat corneas with 3-mm diameter central epithelial abrasions. In control corneas, and in the presence of the cyclooxygenase inhibitors in ... Full text Link to item Cite

THE EFFECT OF PROSTAGLANDIN-E2 ON CORNEAL INFLAMMATION IN THE RAT

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1993 Link to item Cite

THE EFFECT OF PROTEIN-KINASE-C ACTIVATION ON CHOLINERGIC STIMULATION OF PHOSPHOLIPASE-D IN RAT CORNEAL EPITHELIUM

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1993 Link to item Cite

Calcific phacolysis.

Journal Article Ophthalmology · March 1993 BACKGROUND AND METHODS: The authors report the clinical and ocular histopathologic findings in three patients with longstanding unilateral post-traumatic blindness. After one or more decades, acute pain associated with conjunctival hyperemia and apparent k ... Full text Link to item Cite

Effect of protein kinase C inhibitors and activators on corneal re-epithelialization in the rat.

Journal Article Invest Ophthalmol Vis Sci · January 1993 PURPOSE: To examine the ability of protein kinase C (PKC) inhibitors and activators to influence the rate of corneal re-epithelialization in the rat. METHOD: Rat corneas with 3 mm diameter central epithelial abrasions were organ-cultured in control medium ... Link to item Cite

Histopathological variation in keratoconus.

Journal Article Cornea · November 1992 During examination of 131 penetrating keratoplasty specimens from patients with keratoconus obtained in an 11-year period, we observed two histopathologic variants based on the appearance of Bowman's layer and the corneal epithelium. "Typical" keratoconus ... Full text Link to item Cite

Inhibition of corneal neovascularization in the rat by SK&F 86002, a dual inhibitor of arachidonic acid metabolism.

Journal Article Exp Eye Res · July 1992 Full text Link to item Cite

Corneal argyrosis associated with silver soldering.

Journal Article Cornea · May 1992 We report a patient who developed corneal argyrosis secondary to occupational silver soldering. Clinically, the cornea was notable for a green-brown discoloration localized to Descemet's membrane by slit-lamp biomicroscopy. Silver particles were identified ... Link to item Cite

CHOLINERGIC ACTIVATION OF PHOSPHOLIPASE-D IN CULTURED HUMAN RETINAL-PIGMENT EPITHELIUM (RPE)

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1992 Link to item Cite

THE EFFECT OF ANGIOSTATIC STEROIDS AND BETA-CYCLODEXTRIN TETRADECASULFATE ON CORNEAL NEOVASCULARIZATION IN THE RAT

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1992 Link to item Cite

Cat keratoplasty wound healing and corneal astigmatism.

Journal Article Refract Corneal Surg · 1992 BACKGROUND: A major contributor to postkeratoplasty astigmatism may be donor/recipient disparity. Deficient or excess cornea at the wound is thought to influence the directions of the steep and flat meridians. Using an established model of penetrating kera ... Link to item Cite

Amyloid deposition in the eyelids.

Journal Article JAMA · November 20, 1991 Link to item Cite

The effect of total-body irradiation on corneal neovascularization in the Fischer 344 rat after chemical cauterization.

Journal Article Invest Ophthalmol Vis Sci · June 1991 Previous investigations of corneal neovascularization after irradiation yielded discordant results. Most studies indicated that new blood vessel formation in the cornea is inhibited by irradiation. However, others reported that angiogenesis after corneal c ... Link to item Cite

Retrobulbar anesthesia and eyelid closure--effect on corneal angiogenesis.

Journal Article Cornea · May 1991 We evaluated the effect of corneal anesthesia produced by retrobulbar injections of bupivicaine and epinephrine on corneal neovascularization in the rat. The eyelids were sutured closed to prevent dessication and ulceration of the insensitive corneas. The ... Full text Link to item Cite