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Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA.

Publication ,  Journal Article
Morse, MA; Nair, SK; Mosca, PJ; Hobeika, AC; Clay, TM; Deng, Y; Boczkowski, D; Proia, A; Neidzwiecki, D; Clavien, P-A; Hurwitz, HI; Schlom, J ...
Published in: Cancer Invest
June 2003

Immunizations with dendritic cells (DC) transfected with RNA encoding tumor antigens induce potent tumor antigen-specific immune responses in vitro and in murine models. We performed a phase I study of patients with advanced carcinoembryonic antigen (CEA)-expressing malignancies followed by a phase II study of patients with resected hepatic metastases of colon cancer to assess safety and feasibility of administering autologous DC loaded with CEA mRNA. The immunizations were well tolerated. Of the 24 evaluable patients in the dose-escalation phase, there was 1 complete response (by tumor marker), 2 minor responses, 3 with stable disease, and 18 with progressive disease. In the phase II study, 9 of 13 patients have relapsed at a median of 122 days. Evidence of an immunologic response was demonstrated in biopsies of DC injection sites and peripheral blood of selected patients. We conclude that it is feasible and safe to administer mRNA-loaded DC to patients with advanced malignancies.

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Published In

Cancer Invest

DOI

ISSN

0735-7907

Publication Date

June 2003

Volume

21

Issue

3

Start / End Page

341 / 349

Location

England

Related Subject Headings

  • Transplantation, Autologous
  • Transfection
  • Survival Analysis
  • Recombinant Proteins
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Leukapheresis
 

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Morse, M. A., Nair, S. K., Mosca, P. J., Hobeika, A. C., Clay, T. M., Deng, Y., … Lyerly, H. K. (2003). Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA. Cancer Invest, 21(3), 341–349. https://doi.org/10.1081/cnv-120018224
Morse, Michael A., Smita K. Nair, Paul J. Mosca, Amy C. Hobeika, Timothy M. Clay, Yuping Deng, David Boczkowski, et al. “Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA.Cancer Invest 21, no. 3 (June 2003): 341–49. https://doi.org/10.1081/cnv-120018224.
Morse MA, Nair SK, Mosca PJ, Hobeika AC, Clay TM, Deng Y, et al. Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA. Cancer Invest. 2003 Jun;21(3):341–9.
Morse, Michael A., et al. “Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA.Cancer Invest, vol. 21, no. 3, June 2003, pp. 341–49. Pubmed, doi:10.1081/cnv-120018224.
Morse MA, Nair SK, Mosca PJ, Hobeika AC, Clay TM, Deng Y, Boczkowski D, Proia A, Neidzwiecki D, Clavien P-A, Hurwitz HI, Schlom J, Gilboa E, Lyerly HK. Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA. Cancer Invest. 2003 Jun;21(3):341–349.
Journal cover image

Published In

Cancer Invest

DOI

ISSN

0735-7907

Publication Date

June 2003

Volume

21

Issue

3

Start / End Page

341 / 349

Location

England

Related Subject Headings

  • Transplantation, Autologous
  • Transfection
  • Survival Analysis
  • Recombinant Proteins
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Leukapheresis