Scholars@Duke
Henry Elliot Rice

Henry Elliot Rice

Professor of Surgery
Surgery, Pediatric General Surgery
rice0017@mc.duke.edu
Box 3815 Med Ctr, Durham, NC 27710
Room 6680, Hafs, Durham, NC 27710

Selected Publications

Correlation of Genetic Mutation With Outcomes in Children With Hereditary Spherocytosis Undergoing Partial Splenectomy: A Multicentre Study.

Journal Article J Pediatr Surg · April 2025 PURPOSE: Hereditary Spherocytosis (HS) is a common genetic hematological disorder causing a life-long hemolytic anemia, with sequela of hemolysis. Children with severe HS commonly undergo partial or total splenectomy (PS, TS); PS confers the theoretical ad ... Full text Link to item Cite

Predictors of Neurodevelopmental Impairment After Intestinal Resection for Necrotizing Enterocolitis: A Multicenter Retrospective Study.

Journal Article Ann Surg · February 10, 2025 OBJECTIVE: The aim of this study was to evaluate pre-resection risk factors for neurodevelopmental impairment (NDI) in infants with necrotizing enterocolitis (NEC) that might better inform the timing of intestinal resection. SUMMARY BACKGROUND DATA: Surgic ... Full text Link to item Cite

Financial impact and healthcare expenditures among surgical patients in Burundi.

Journal Article World J Surg · February 2025 BACKGROUND: The largest proportion of people at risk of catastrophic expenditures for surgical care live in low- and middle-income countries. This study aims to evaluate the financial impact among surgical patients at Kibuye Hope Hospital (KHH) in Burundi. ... Full text Link to item Cite

Surgical Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Lead to Severe Growth Failure in Infants.

Journal Article Ann Surg · September 1, 2024 OBJECTIVE: We aimed to determine the incidence of growth failure in infants with necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP) and whether initial laparotomy versus peritoneal drainage (PD) impacted the likelihood of growth fa ... Full text Link to item Cite

Impact of the COVID-19 pandemic in childhood and adolescent cancer care in northern Tanzania: a cross-sectional study.

Journal Article BMC Cancer · April 12, 2024 INTRODUCTION: The SARS-CoV-2 (COVID-19) pandemic has strained healthcare systems and presented unique challenges for children requiring cancer care, particularly in low- and middle-income countries. This study aimed to assess the impact of the COVID-19 pan ... Full text Link to item Cite

Contemporary trends in choledochal cyst excision: An analysis of the pediatric national surgical quality improvement program.

Journal Article World J Surg · April 2024 BACKGROUND: Choledochal cysts are rare congenital anomalies of the biliary tree that may lead to obstruction, chronic inflammation, infection, and malignancy. There is wide variation in the timing of resection, operative approach, and reconstructive techni ... Full text Link to item Cite

Effect of Early vs Late Inguinal Hernia Repair on Serious Adverse Event Rates in Preterm Infants: A Randomized Clinical Trial.

Journal Article JAMA · March 26, 2024 IMPORTANCE: Inguinal hernia repair in preterm infants is common and is associated with considerable morbidity. Whether the inguinal hernia should be repaired prior to or after discharge from the neonatal intensive care unit is controversial. OBJECTIVE: To ... Full text Link to item Cite

Modeling the global impact of reducing out-of-pocket costs for children's surgical care.

Journal Article PLOS Glob Public Health · 2024 Over 1.7 billion children lack access to surgical care, mostly in low- and middle-income countries (LMICs), with substantial risks of catastrophic health expenditures (CHE) and impoverishment. Increasing interest in reducing out-of-pocket (OOP) expenditure ... Full text Link to item Cite

Understanding family-level decision-making when seeking access to acute surgical care for children: Protocol for a cross-sectional mixed methods study.

Journal Article PLoS One · 2024 BACKGROUND: There is limited understanding of how social determinants of health (SDOH) impact family decision-making when seeking surgical care for children. Our objectives of this study are to identify key family experiences that contribute to decision-ma ... Full text Link to item Cite

Lived experiences of people impacted by gun violence: qualitative analysis of the prescriptions for repair project.

Journal Article Trauma Surg Acute Care Open · 2024 BACKGROUND: Restorative justice interventions can help address the harm created by gun violence, although few restorative justice programs focus solely on survivors or loved ones of victims of gun violence. Our aim was to assess how gun violence impacts th ... Full text Link to item Cite

Towards attainment of the 2030 goal for childhood cancer survival for the World Health Organization Global Initiative for Childhood Cancer: An ecological, cross-sectional study.

Journal Article PLOS Glob Public Health · 2024 The World Health Organization (WHO) recently launched the Global Initiative for Childhood Cancer (GICC), with the goal of attaining at least 60% cancer survival for children worldwide by the year 2030. This study aims to describe the global patterns of chi ... Full text Link to item Cite

Assessment of anesthesia capacity for children in Somaliland.

Journal Article PLOS Glob Public Health · 2024 The burden of pediatric surgical conditions in Somaliland is high and the pediatric anesthesia capacity across the country remains poorly understood. The international standards developed by the World Health Organization and World Federation of Societies o ... Full text Link to item Cite

Cost effectiveness and return on investment analysis for surgical care in a conflict-affected region of Sudan.

Journal Article PLOS Glob Public Health · 2024 The delivery of healthcare in conflict-affected regions places tremendous strains to health systems, and the economic value of surgical care in conflict settings remains poorly understood. Our aims were to evaluate the cost-effectiveness, societal economic ... Full text Link to item Cite

"It's his cheerfulness that gives me hope": A qualitative analysis of access to pediatric cancer care in Northern Tanzania.

Journal Article PLOS Glob Public Health · 2024 Pediatric cancer is a significant and growing burden in low- and middle-income countries. The objective of this project was to describe the factors influencing access to pediatric cancer care in Northern Tanzania using the Three Delays Model. This was a cr ... Full text Link to item Cite

Defining Feasibility as a Criterion for Essential Surgery: A Qualitative Study with Global Children's Surgery Experts.

Journal Article World J Surg · December 2023 BACKGROUND: The Disease Control Priorities (DCP-3) group defines surgery as essential if it addresses a significant burden, is cost-effective, and is feasible-yet the feasibility component remains largely unexplored. The aim of this study was to develop a ... Full text Link to item Cite

Childhood and Adolescent Cancer Care at a Tertiary Hospital in Northern Tanzania: A Retrospective Study.

Journal Article JCO Glob Oncol · June 2023 PURPOSE: Over 400,000 children are diagnosed with cancer around the world each year, with over 80% of these children residing in low- and middle-income countries. This study aims to summarize the epidemiology and care patterns of newly diagnosed childhood ... Full text Link to item Cite

Does reducing out-of-pocket costs for children's surgical care protect families from poverty in Somaliland? A cross-sectional, national, economic evaluation modelling study.

Journal Article BMJ Open · May 2, 2023 OBJECTIVES: An estimated 1.7 billion children around the world do not have access to safe, affordable and timely surgical care, with the financing through out-of-pocket (OOP) expenses being one of the main barriers to care. Our study modelled the impact of ... Full text Link to item Cite

Delays in cancer care for children in low-income and middle-income countries: development of a composite vulnerability index.

Journal Article Lancet Glob Health · April 2023 BACKGROUND: Early access to diagnosis and care is essential to improve rates of survival from childhood cancer, particularly in low-income and middle-income countries (LMICs). Composite indices are increasingly used to compare country performance in many h ... Full text Link to item Cite

Determinants of delayed childhood cancer care in low- and middle-income countries: A systematic review.

Journal Article Pediatr Blood Cancer · March 2023 Early access to care is essential to improve survival rates for childhood cancer. This study evaluates the determinants of delays in childhood cancer care in low- and middle-income countries (LMICs) through a systematic review of the literature. We propose ... Full text Link to item Cite

Delays in care for hydrocephalus and spina bifida at a tertiary hospital in Somaliland.

Journal Article World J Pediatr Surg · 2023 BACKGROUND: Childhood neurosurgical conditions such as hydrocephalus and spina bifida represent a significant burden of death and disability worldwide, particularly in low and middle-income countries. However, there are limited data on the disease prevalen ... Full text Link to item Cite

With equity in mind: Evaluating an interactive hybrid global surgery course for cross-site interdisciplinary learners.

Journal Article PLOS Glob Public Health · 2023 There is limited understanding of the role of transcultural, cross-site educational partnerships for global surgery training between high- and low- or middle-income country (LMIC) institutions. We describe the development, delivery, and appraisal of a hybr ... Full text Link to item Cite

Modeling the Scale-up of Surgical Services for Children with Surgically Treatable Congenital Conditions in Somaliland.

Journal Article World J Surg · October 2022 BACKGROUND: Congenital conditions comprise a significant portion of the global burden of surgical conditions in children. In Somaliland, over 250,000 children do not receive required surgical care annually, although the estimated costs and benefits of scal ... Full text Link to item Cite

Defining Surgical Workforce Density Targets to Meet Child and Neonatal Mortality Rate Targets in the Age of the Sustainable Development Goals: A Global Cross-Sectional Study.

Journal Article World J Surg · September 2022 OBJECTIVES: To reduce preventable deaths of newborns and children, the United Nations set a target rate per 1000 live births of 12 for neonatal mortality (NMR) and 25 for under-5 mortality (U5MR). The purpose of this paper is to define the minimum surgical ... Full text Link to item Cite

Implementation challenges to patient safety in Guatemala: a mixed methods evaluation.

Journal Article BMJ Qual Saf · May 2022 BACKGROUND: Little is known about factors affecting implementation of patient safety programmes in low and middle-income countries. The goal of our study was to evaluate the implementation of a patient safety programme for paediatric care in Guatemala. MET ... Full text Open Access Link to item Cite

Factors contributing to delayed childhood cancer care in low- and middle-income countries: A systematic review protocol.

Journal Article Pediatr Blood Cancer · May 2022 BACKGROUND: Significant disparities exist for timely access to cancer care for children, with the highest disparities in low- and middle-income countries (LMICs). This study aims to conduct a systematic review that identifies the factors contributing to de ... Full text Link to item Cite

Surgical Site Infection in Children with Neuromuscular Disorders after Laparoscopic Gastrostomy: A Propensity-Matched National Surgical Quality Improvement Program Pediatrics Database Analysis.

Journal Article Surg Infect (Larchmt) · April 2022 Background: Prior studies have demonstrated that children with neuromuscular scoliosis have a higher incidence of infection after spine surgery. The purpose of the study is to determine whether children with neuromuscular disorders (NMDs) have higher rate ... Full text Link to item Cite

Biliary atresia in a neonate with a history of COVID-19: A case report.

Journal Article Int J Surg Case Rep · January 2022 INTRODUCTION AND IMPORTANCE: Biliary Atresia is the progressive destruction of the neonatal intra- and extra- hepatic bile ducts. The novel coronavirus has shown dramatic hepatic tropism, and patients experiencing liver injury appear to have worse outcomes ... Full text Link to item Cite

The epidemiology of pediatric traumatic brain injury presenting at a referral center in Moshi, Tanzania.

Journal Article PLoS One · 2022 BACKGROUND: Over 95% of childhood injury deaths occur in low- and middle-income countries (LMICs). Patients with severe traumatic brain injury (TBI) have twice the likelihood of dying in LMICs than in high-income countries (HICs). In Africa, TBI estimates ... Full text Link to item Cite

Assessing the cost and economic impact of tertiary-level pediatric cancer care in Tanzania.

Journal Article PLoS One · 2022 BACKGROUND: Worldwide, an estimated 400,000 children develop cancer each year. The bulk of the mortalities from these cases occur in low-and-middle-income countries (LMICs). In Sub-Saharan Africa, there is a tremendous need to strengthen the capacity of he ... Full text Link to item Cite

Challenges with pediatric surgical financing and universal health coverage in Guatemala: A qualitative analysis.

Journal Article PLOS Glob Public Health · 2022 The financing of surgical care for children in low- and middle-income countries (LMICs) remains challenging and may restrict adherence to universal health coverage (UHC) frameworks. Our aims were to describe Guatemala's national pediatric surgical financin ... Full text Link to item Cite

Surgical Disorders of the Spleen

Chapter · January 1, 2022 Splenectomy is often considered for children with various benign and malignant conditions. Total splenectomy (TS) or partial splenectomy (PS) can safely be performed in children with minimal risks, although understanding the indications, expected benefits, ... Full text Cite

Association between government policy and delays in emergent and elective surgical care during the COVID-19 pandemic in Brazil: a modeling study.

Journal Article Lancet Reg Health Am · November 2021 BACKGROUND: The impact of public health policy to reduce the spread of COVID-19 on access to surgical care is poorly defined. We aim to quantify the surgical backlog during the COVID-19 pandemic in the Brazilian public health system and determine the relat ... Full text Link to item Cite

Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial.

Journal Article Ann Surg · October 1, 2021 OBJECTIVE: The aim of this study was to determine which initial surgical treatment results in the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with necrotizing enterocolitis (NEC) or isolated intestinal perforation (IP). ... Full text Link to item Cite

Potentially Avertable Child Mortality Associated with Surgical Workforce Scale-up in Low- and Middle-Income Countries: A Global Study.

Conference World J Surg · September 2021 BACKGROUND: Expansion of access to surgical care can improve health outcomes, although the impact that scale-up of the surgical workforce will have on child mortality is poorly defined. In this study, we estimate the number of child deaths potentially aver ... Full text Link to item Cite

Open versus minimally-invasive surgical techniques in pediatric renal tumors: A population-level analysis of in-hospital outcomes.

Journal Article J Pediatr Urol · August 2021 INTRODUCTION: Minimally-invasive surgery (MIS) has been adopted slowly in pediatric oncology. We attempted to describe contemporary national trends in MIS use; we hypothesized that adolescents (who are more likely to have relatively small renal cell carcin ... Full text Link to item Cite

Geospatial analysis of pediatric surgical need and geographical access to care in Somaliland: a cross-sectional study.

Journal Article BMJ Open · July 21, 2021 BACKGROUND: The global burden of disease in children is large and disproportionally affects low-income and middle-income countries (LMICs). Geospatial analysis offers powerful tools to quantify and visualise disparities in surgical care in LMICs. Our study ... Full text Link to item Cite

Global and regional overview of the inclusion of paediatric surgery in the national health plans of 124 countries: an ecological study.

Journal Article BMJ Open · June 16, 2021 OBJECTIVE: This study evaluates the priority given to surgical care for children within national health policies, strategies and plans (NHPSPs). PARTICIPANTS AND SETTING: We reviewed the NHPSPs available in the WHO's Country Planning Cycle Database. Countr ... Full text Link to item Cite

Development of an Interactive Global Surgery Course for Interdisciplinary Learners.

Journal Article Ann Glob Health · March 31, 2021 INTRODUCTION: Global surgical care is increasingly recognized in the global health agenda and requires multidisciplinary engagement. Despite high interest among medical students, residents and other learners, many surgical faculty and health experts remain ... Full text Open Access Link to item Cite

Interpreting the Lancet surgical indicators in Somaliland: a cross-sectional study.

Journal Article BMJ Open · December 29, 2020 BACKGROUND: The unmet burden of surgical care is high in low-income and middle-income countries. The Lancet Commission on Global Surgery (LCoGS) proposed six indicators to guide the development of national plans for improving and monitoring access to essen ... Full text Link to item Cite

Pancreaticoduodenectomy for the treatment of pancreatic neoplasms in children: A Pediatric Surgical Oncology Research Collaborative study.

Journal Article Pediatr Blood Cancer · September 2020 BACKGROUND: To better characterize short-term and long-term outcomes in children with pancreatic tumors treated with pancreaticoduodenectomy (PD). METHODS: Patients 21 years of age or younger who underwent PD at Pediatric Surgical Oncology Collaborative (P ... Full text Link to item Cite

LONG-TERM HEMATOLOGIC AND CLINICAL OUTCOMES OF SPLENECTOMY IN CHILDREN WITH HEREDITARY SPHEROCYTOSIS AND SICKLE CELL DISEASE.

Journal Article Pediatr Blood Cancer · August 2020 BACKGROUND: Total splenectomy (TS) and partial splenectomy (PS) are used for children with congenital hemolytic anemia (CHA), although the long-term outcomes of these procedures are poorly defined. This report describes long-term outcomes of children with ... Full text Link to item Cite

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study.

Journal Article Lancet · July 4, 2020 BACKGROUND: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmo ... Full text Link to item Cite

Implementation Analysis of a Perioperative Patient Safety Program in Guatemala.

Journal Article World J Surg · July 2020 BACKGROUND: The implementation of programs to improve patient safety remains challenging in low- and middle-income countries. The goal of our study was to define the barriers and facilitators to implementation of a perioperative patient safety program in G ... Full text Link to item Cite

Barriers to Surgical Care Among Children in Somaliland: An Application of the Three Delays Framework.

Journal Article World J Surg · June 2020 BACKGROUND: There are complex barriers that increase delays to surgical care in low- and middle-income countries, particularly among the vulnerable population of children. Understanding these barriers to surgical care can result in targeted and strategic i ... Full text Link to item Cite

Towards defining the surgical workforce for children: a geospatial analysis in Brazil.

Journal Article BMJ Open · March 24, 2020 OBJECTIVES: The optimal size of the health workforce for children's surgical care around the world remains poorly defined. The goal of this study was to characterise the surgical workforce for children across Brazil, and to identify associations between th ... Full text Link to item Cite

Waiting Too Long: The Contribution of Delayed Surgical Access to Pediatric Disease Burden in Somaliland.

Journal Article World J Surg · March 2020 BACKGROUND: Delayed access to surgical care for congenital conditions in low- and middle-income countries is associated with increased risk of death and life-long disabilities, although the actual burden of delayed access to care is unknown. Our goal was t ... Full text Link to item Cite

Perspectives on perioperative management of children's surgical conditions during the COVID-19 pandemic in low-income and middle-income countries: a global survey.

Journal Article World J Pediatr Surg · 2020 BACKGROUND: Many organizations have issued recommendations to limit elective surgery during the coronavirus disease 2019 (COVID-19) pandemic. We surveyed providers of children's surgical care working in low-income and middle-income countries (LMICs) to und ... Full text Link to item Cite

Partial and radical nephrectomy in children, adolescents, and young adults: Equivalent readmissions and postoperative complications.

Journal Article J Pediatr Surg · November 2019 OBJECTIVES: To compare and contrast the use of partial nephrectomy (PN) and radical nephrectomy (RN) in pediatric malignant renal tumors using a nationally representative database. METHODS: The 2010-2014 Nationwide Readmissions Database (NRD) was used to o ... Full text Link to item Cite

Provision of Surgical Care for Children Across Somaliland: Challenges and Policy Guidance.

Journal Article World J Surg · November 2019 BACKGROUND: Existing data suggest a large burden of surgical conditions in low- and middle-income countries (LMICs). However, surgical care for children in LMICs remains poorly understood. Our goal was to define the hospital infrastructure, workforce, and ... Full text Link to item Cite

Immune expression in children with Wilms tumor: a pilot study.

Journal Article J Pediatr Urol · October 2019 BACKGROUND: Given improvements in multimodality therapy, survival among children with Wilms tumor (WT) exceeds 90%. However, 15% of children with favorable histology and 50% of children with anaplastic WT experience recurrence or progression. Of patients w ... Full text Link to item Cite

Cervical seatbelt sign is not associated with blunt cerebrovascular injury in children: A review of the national trauma databank.

Journal Article Am J Surg · July 2019 BACKGROUND: Blunt cerebrovascular injury (BCVI) is a rare consequence of blunt trauma. There appears to be benefit to an aggressive approach to screening for BCVI due to catastrophic sequelae of unrecognized injury. However, screening for BCVI carries exte ... Full text Link to item Cite

Global Initiative for Children's Surgery: A Model of Global Collaboration to Advance the Surgical Care of Children.

Journal Article World J Surg · June 2019 BACKGROUND: Recommendations by the Lancet Commission on Global Surgery regarding surgical care in low- and middle-income countries (LMICs) require development to address the needs of children. The Global Initiative for Children's Surgery (GICS) was founded ... Full text Link to item Cite

Outcomes of laparoscopic resection of Meckel's diverticulum are equivalent to open laparotomy.

Journal Article J Pediatr Surg · March 2019 PURPOSE: Meckel's diverticulum (MD) is a common congenital anomaly caused by failure of involution of the omphalomesenteric duct. Enthusiasm for minimally invasive surgery (MIS) in children has burgeoned as technologies have advanced, but the outcomes of l ... Full text Link to item Cite

Global Surgery: Building Healthy Surgical Systems.

Journal Article J Pak Med Assoc · February 2019 Global Surgery (GS) is a movement that advocates access of every individual to safe and affordable surgery despite geographic location or socioeconomic status. It has recently received increased attention within the global health arena, but many patients a ... Link to item Cite

Prevalence of Pediatric Surgical Conditions Across Somaliland.

Journal Article JAMA Netw Open · January 4, 2019 IMPORTANCE: Although surgical conditions are increasingly recognized as causing a significant health care burden among adults in low- and middle-income countries (LMICs), the burden of surgical conditions among children in LMICs remains poorly defined. OBJ ... Full text Link to item Cite

Temporal Delays Along the Neurosurgical Care Continuum for Traumatic Brain Injury Patients at a Tertiary Care Hospital in Kampala, Uganda.

Journal Article Neurosurgery · January 1, 2019 BACKGROUND: Significant care continuum delays between acute traumatic brain injury (TBI) and definitive surgery are associated with poor outcomes. Use of the "3 delays" model to evaluate TBI outcomes in low- and middle-income countries has not been perform ... Full text Open Access Link to item Cite

Teaching patient safety in global health: lessons from the Duke Global Health Patient Safety Fellowship.

Journal Article BMJ Glob Health · 2019 Health systems in low-income and middle-income countries (LMICs) have a high burden of medical errors and complications, and the training of local experts in patient safety is critical to improve the quality of global healthcare. This analysis explores our ... Full text Link to item Cite

The contribution of pediatric surgery to poverty trajectories in Somaliland.

Journal Article PLoS One · 2019 BACKGROUND: The provision of health care in low-income and middle-income countries (LMICs) is recognized as a significant contributor to economic growth and also impacts individual families at a microeconomic level. The primary goal of our study was to exa ... Full text Link to item Cite

Developing a national patient safety plan in Guatemala.

Journal Article Rev Panam Salud Publica · 2019 OBJECTIVE: Patient safety is challenging for health systems around the world, particularly in low-and middleincome countries such as Guatemala. The goal of this report is to summarize a strategic planning process for a national patient safety plan in Guate ... Full text Link to item Cite

Disparities in surgical care for children across Brazil: Use of geospatial analysis.

Journal Article PLoS One · 2019 BACKGROUND: Health systems for surgical care for children in low- and middle-income countries remain poorly understood. Our goal was to characterize the delivery of surgical care for children across Brazil and to identify associations between surgical reso ... Full text Link to item Cite

Wilms Tumor After Orthotopic Liver Transplant in a Patient With Alagille Syndrome.

Journal Article Urology · November 2018 We present a case of Wilms Tumor in a patient with Alagille syndrome 10 months after liver transplant. We explore a suggested genetic connection between these 2 diseases. In children with Wilms Tumor, we propose a pathoembryologic explanation for not just ... Full text Link to item Cite

Racial/ethnic differences in necrotizing enterocolitis incidence and outcomes in premature very low birth weight infants.

Journal Article J Perinatol · October 2018 BACKGROUND: As advances in neonatal intensive care increase the survival of extremely premature infants, the at-risk population for necrotizing enterocolitis (NEC) continues to rise. Although racial health disparities in preterm births have been well docum ... Full text Link to item Cite

Disability Weights for Pediatric Surgical Procedures: A Systematic Review and Analysis.

Journal Article World J Surg · September 2018 BACKGROUND: Metrics to measure the burden of surgical conditions, such as disability weights (DWs), are poorly defined, particularly for pediatric conditions. To summarize the literature on DWs of children's surgical conditions, we performed a systematic r ... Full text Link to item Cite

Implementation of a colour-coded universal protocol safety initiative in Guatemala.

Journal Article BMJ Qual Saf · August 2018 BACKGROUND: Universal protocol implementation can be challenging in low-income or middle-income countries, particularly when providers work together across language barriers. The aim of this quality improvement initiative was to test the implementation of ... Full text Link to item Cite

Freedom of choice, expressions of gratitude: Patient experiences of short-term surgical missions in Guatemala.

Journal Article Soc Sci Med · July 2018 Lack of surgical care has been highlighted as a critical global health problem, and short-term medical missions (STMMs) have become a de facto measure to address this shortfall. Participation in STMMs is an increasingly popular activity for foreign medical ... Full text Link to item Cite

A multi-institution analysis of predictors of timing of inguinal hernia repair among premature infants.

Journal Article J Pediatr Surg · April 2018 PURPOSE: Inguinal hernias are common in premature infants, but there is substantial variation with regards to timing of repair. We sought to quantify and explain this variation. METHODS: Cohort study of infants <34weeks gestation diagnosed with an inguinal ... Full text Link to item Cite

Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor.

Journal Article Pediatr Blood Cancer · January 2018 BACKGROUND: Minimally invasive surgery (MIS) has been widely adopted for common operations in pediatric surgery; however, its role in childhood tumors is limited by concerns about oncologic outcomes. We compared open and MIS approaches for pediatric neurob ... Full text Link to item Cite

Building a safety culture in global health: lessons from Guatemala.

Journal Article BMJ Glob Health · 2018 Programmes to modify the safety culture have led to lasting improvements in patient safety and quality of care in high-income settings around the world, although their use in low-income and middle-income countries (LMICs) has been limited. This analysis ex ... Full text Open Access Link to item Cite

A systematic review and quality analysis of pediatric traumatic brain injury clinical practice guidelines.

Journal Article PLoS One · 2018 BACKGROUND: Traumatic brain injuries (TBI) are a significant cause of mortality and morbidity for children globally. Adherence to evidence-based treatment guidelines have been shown to improve TBI outcomes. To inform the creation of a pediatric TBI managem ... Full text Link to item Cite

Renal medullary carcinoma: A national analysis of 159 patients.

Journal Article Pediatr Blood Cancer · November 2017 BACKGROUND: Renal medullary carcinoma (RMC) is an aggressive malignancy seen predominantly in young males with sickle cell trait. RMC is poorly understood, with fewer than 220 cases described in the medical literature to date. We used a large national regi ... Full text Link to item Cite

Outcomes following elective resection of congenital pulmonary airway malformations are equivalent after 3 months of age and a weight of 5 kg.

Journal Article J Pediatr Surg · October 9, 2017 PURPOSE: Resection of congenital pulmonary airway malformations (CPAMs) is often performed to reduce the risk of recurrent infection and malignant transformation. However, there is substantial variation in the timing of resection. This study was performed ... Full text Link to item Cite

Children Receiving Hematopoietic Stem Cell Transplantation are at Increased Risk of Onychocryptosis Requiring Surgical Management.

Journal Article J Pediatr Hematol Oncol · October 2017 PURPOSE: At our institution, a high proportion of children with onychocryptosis (ingrown toenail) requiring surgical intervention were noted to have a history of hematopoietic stem cell transplantation (HSCT). We analyzed the characteristics of patients wh ... Full text Link to item Cite

Thoracoscopic Approach Provides a Safe Alternative to Open Surgery in Elective Cases for Newborns

Conference Journal of the American College of Surgeons · October 2017 Full text Cite

ACR Appropriateness Criteria® Urinary Tract Infection-Child.

Journal Article J Am Coll Radiol · May 2017 Urinary tract infection (UTI) is common in young children and may cause pyelonephritis and renal scarring. Long-term complications from renal scarring are low. The role of imaging is to evaluate for underlying urologic abnormalities and guide treatment. In ... Full text Link to item Cite

Vascular Complications in Pediatric Port Removal.

Journal Article Am Surg · April 1, 2017 Link to item Cite

Vascular Complications in Pediatric Port Removal.

Journal Article Am Surg · April 1, 2017 Link to item Cite

Vascular Complications in Pediatric Port Removal.

Journal Article Am Surg · April 1, 2017 Link to item Cite

Perioperative outcomes for pediatric neurosurgical procedures: analysis of the National Surgical Quality Improvement Program-Pediatrics.

Journal Article J Neurosurg Pediatr · March 2017 OBJECTIVE Existing studies have shown a high overall rate of adverse events (AEs) following pediatric neurosurgical procedures. However, little is known regarding the morbidity of specific procedures or the association with risk factors to help guide quali ... Full text Link to item Cite

Gallbladder abnormalities in children with metachromatic leukodystrophy.

Journal Article J Surg Res · February 2017 BACKGROUND: Metachromatic leukodystrophy (MLD) is a lysosomal storage disease that leads to neurological deterioration and visceral involvement, including sulphatide deposition in the gallbladder wall. Using our institution's extensive experience in treati ... Full text Open Access Link to item Cite

Morbidity and healthcare costs of vascular anomalies: a national study.

Journal Article Pediatr Surg Int · February 2017 PURPOSE: This study aimed to define morbidities and costs related to modern-day medical care for children with vascular anomalies. METHODS: We reviewed the 2003-2009 Kids' Inpatient Database for pediatric patients (age < 21 years) hospitalized with hemangi ... Full text Link to item Cite

Onychocryptosis in the Pediatric Patient.

Journal Article Clin Pediatr (Phila) · February 2017 Full text Link to item Cite

Predictors of nodal metastasis in pediatric differentiated thyroid cancer.

Journal Article J Pediatr Surg · January 2017 BACKGROUND/PURPOSE: There are limited data identifying risk factors for nodal metastasis in children with differentiated thyroid cancer. METHODS: The 1998-2011 Surveillance, Epidemiology, and End Results Program database was queried for patients ≤18years o ... Full text Link to item Cite

Current use and outcomes of helicopter transport in pediatric trauma: a review of 18,291 transports.

Journal Article J Pediatr Surg · January 2017 PURPOSE: The role of helicopter emergency medical services (HEMS) in pediatric trauma remains controversial. We examined its use in pediatric trauma and its effectiveness in children with moderate/severe injuries. METHODS: All blunt/penetrating trauma pati ... Full text Link to item Cite

Influence of weight at enterostomy reversal on surgical outcomes in infants after emergent neonatal stoma creation.

Journal Article J Pediatr Surg · January 2017 PURPOSE: Neonates after emergent enterostomy creation frequently require reversal at low weight because of complications including cholestasis, dehydration, dumping, failure to thrive, and failure to achieve enteral independence. We investigated whether st ... Full text Link to item Cite

Extracorporeal life support use in pediatric trauma: a review of the National Trauma Data Bank.

Journal Article J Pediatr Surg · January 2017 PURPOSE: As the role of extracorporeal life support (ECLS) continues to evolve in the adult and pediatric populations, smaller studies and case reports have described successful use of ECLS in specific groups of pediatric trauma patients. To further define ... Full text Link to item Cite

A prospective neurosurgical registry evaluating the clinical care of traumatic brain injury patients presenting to Mulago National Referral Hospital in Uganda.

Journal Article PLoS One · 2017 BACKGROUND: Traumatic Brain Injury (TBI) is disproportionally concentrated in low- and middle-income countries (LMICs), with the odds of dying from TBI in Uganda more than 4 times higher than in high income countries (HICs). The objectives of this study ar ... Full text Open Access Link to item Cite

Postoperative Venous Thromboembolism in Children Is Increased in Setting of Cancer or Infection

Conference Blood · December 2, 2016 AbstractBackground: Venous thromboembolism (VTE) is an uncommon but clinically significant postoperative complication in children. Incidence of VTE in pediatric patients ranges from 34-58 per 10,000 hospital ... Full text Cite

Biomarkers for Wilms Tumor: A Systematic Review.

Journal Article J Urol · November 2016 PURPOSE: Wilms tumor is the most common childhood renal malignancy and the fourth most common childhood cancer. Many biomarkers have been studied but there has been no comprehensive summary. We systematically reviewed the literature on biomarkers in Wilms ... Full text Link to item Cite

Comparative effectiveness of treatment strategies for severe splenic trauma in the pediatric population.

Journal Article Am J Surg · October 2016 BACKGROUND: Splenic angioembolization (SAE) is increasingly used in the management of splenic injuries in adults, although its value in pediatric trauma is unclear. We sought to assess outcomes related to splenectomy vs SAE. METHODS: The National Trauma Da ... Full text Link to item Cite

Laparoscopy Is Safe in Infants and Neonates with Congenital Heart Disease: A National Study of 3684 Patients.

Journal Article J Laparoendosc Adv Surg Tech A · October 2016 PURPOSE: Concerns have been raised about the use of laparoscopic surgery (LS) in infants with congenital heart disease (CHD) due to their unique physiology. Prior studies on the safety and effectiveness of laparoscopy in children with CHD are limited in sc ... Full text Link to item Cite

Management of blunt pancreatic trauma in children: Review of the National Trauma Data Bank.

Journal Article J Pediatr Surg · September 2016 PURPOSE: This study aims to examine the current management strategies and outcomes after blunt pancreatic trauma in children using a national patient registry. METHODS: Using the National Trauma Data Bank (NTDB) from 2007-2011, we identified all patients ≤ ... Full text Link to item Cite

ACR Appropriateness Criteria Fever Without Source or Unknown Origin-Child.

Journal Article J Am Coll Radiol · August 2016 The cause of fever in a child can often be determined from history, physical examination, and laboratory tests; infections account for the majority of cases. Yet in 20%, no apparent cause can be found, designated as fever without source (FWS). The yield of ... Full text Link to item Cite

Sentinel lymph node biopsy is a prognostic measure in pediatric melanoma.

Journal Article J Pediatr Surg · June 2016 BACKGROUND/PURPOSE: Sentinel lymph node biopsy (SLNB)-based management has been shown to improve disease-free survival in adult melanoma, but there is scant evidence regarding the utility of SLNB in pediatric melanoma. METHODS: The 2004-2011 Surveillance, ... Full text Link to item Cite

Nephron-sparing surgery for Wilms tumor: A systematic review.

Journal Article Urol Oncol · January 2016 INTRODUCTION: Radical nephrectomy (RN, or total nephrectomy) is the current gold-standard surgical treatment for children with Wilms tumors (WT). However, nephron-sparing surgery (NSS, or partial nephrectomy) has recently been gaining increasing attention. ... Full text Link to item Cite

Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia.

Journal Article J Pediatr Surg · January 2016 PURPOSE: The purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD). METHODS: The Splenectomy in Congenital Hemolytic An ... Full text Link to item Cite

Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB).

Journal Article J Pediatr Surg · January 2016 PURPOSE: Adrenocortical carcinoma (ACC) is a rare tumor in children with important distinctions from the adult disease. We reviewed the National Cancer Data Base (NCDB) to determine factors associated with long-term survival. METHODS: The NCDB was queried ... Full text Link to item Cite

Economic Analysis of Children's Surgical Care in Low- and Middle-Income Countries: A Systematic Review and Analysis.

Journal Article PLoS One · 2016 BACKGROUND: Understanding the economic value of health interventions is essential for policy makers to make informed resource allocation decisions. The objective of this systematic review was to summarize available information on the economic impact of chi ... Full text Open Access Link to item Cite

Surgical disorders of the spleen

Chapter · January 1, 2016 For children with many conditions, splenectomy can cure the disease or effectively control the associated clinical symptoms. However, the risks associated with splenectomy such as overwhelming postsplenectomy sepsis are not trivial, and there is increasing ... Full text Cite

Mycotic Saccular Abdominal Aortic Aneurysm in an Infant after Cardiac Catheterization: A Case Report.

Journal Article Ann Vasc Surg · October 2015 Abdominal aortic aneurysms (AAAs) are a rare entity in the pediatric population. Children with mycotic (infectious) AAA in particular are at risk of life-threatening rupture due to their rapid expansion coupled with aortic wall thinning and deterioration. ... Full text Link to item Cite

Value of surgical resection in children with high-risk neuroblastoma.

Journal Article Pediatr Blood Cancer · September 2015 BACKGROUND: The value of gross total resection (GTR) for children with high-risk neuroblastoma (NB) is controversial. We hypothesized that patients undergoing GTR would demonstrate improved overall survival (OS) compared those having Full text Link to item Cite

Use of patient registries and administrative datasets for the study of pediatric cancer.

Journal Article Pediatr Blood Cancer · September 2015 Analysis of data from large administrative databases and patient registries is increasingly being used to study childhood cancer care, although the value of these data sources remains unclear to many clinicians. Interpretation of large databases requires a ... Full text Link to item Cite

ACR Appropriateness Criteria Vomiting in Infants up to 3 Months of Age.

Journal Article J Am Coll Radiol · September 2015 Vomiting is a commonly reported symptom in infants less than three months of age. There are a multitude of pathologies to consider, both within and outside the gastrointestinal tract. In addition to conducting a thorough history and physical examination, a ... Full text Link to item Cite

Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry.

Journal Article Am J Hematol · March 2015 The outcomes of children with congenital hemolytic anemia (CHA) undergoing total splenectomy (TS) or partial splenectomy (PS) remain unclear. In this study, we collected data from 100 children with CHA who underwent TS or PS from 2005 to 2013 at 16 sites i ... Full text Link to item Cite

Self-reported barriers to pediatric surgical care in Guatemala.

Journal Article Am Surg · September 2013 Access to pediatric surgical care is limited in low- and middle-income countries. Barriers must be identified before improvements can be made. This pilot study aimed to identify self-reported barriers to pediatric surgical care in Guatemala. We surveyed 78 ... Link to item Cite

Pediatric injury patterns by year of age.

Journal Article J Pediatr Surg · June 2013 PURPOSE: Since trauma is the leading cause of death and disability among children, understanding injury patterns may reduce morbidity and mortality through targeted prevention efforts. The purpose of this study was to identify pediatric injury patterns by ... Full text Link to item Cite

Telephone follow-up for pediatric ambulatory surgery: parent and provider satisfaction.

Journal Article J Pediatr Nurs · December 2012 Traditional 4- to 6-week clinic follow-up after pediatric ambulatory surgery does not rapidly identify complications and is often a burden for parents. Telephone follow-up offers support and is preferred in a variety of adult populations, but there is litt ... Full text Link to item Cite

Evaluation of partial and total splenectomy in children with sickle cell disease using an Internet-based registry.

Journal Article Pediatr Blood Cancer · July 15, 2012 BACKGROUND: Clinical outcomes of children with sickle cell disease (SCD) who undergo total or partial splenectomy (PS) are poorly defined. The purpose of this retrospective study was to initiate an Internet-based registry to facilitate analysis of clinical ... Full text Link to item Cite

Comparative effectiveness of different types of splenectomy for children with congenital hemolytic anemias.

Journal Article J Pediatr · April 2012 OBJECTIVE: To compare the effectiveness of different types of splenectomy in children with congenital hemolytic anemias. STUDY DESIGN: We constructed key questions that addressed outcomes relevant to clinicians and families on effects of partial or total s ... Full text Link to item Cite

Disorders of the spleen

Journal Article · December 1, 2011 Knowledge of the unique splenic anatomy is essential to guide surgical therapy. The spleen develops within the dorsal mesogastrium during the fifth week of gestation and is located in the left upper quadrant of the abdomen. It abuts the diaphragm superiorl ... Full text Cite

Impact of hydroxyurea on perioperative management and outcomes in children with sickle cell anemia.

Journal Article J Pediatr Hematol Oncol · October 2011 Hydroxyurea has enhanced the treatment for children with sickle cell anemia. The objectives of this study were to compare perioperative transfusions and outcomes for children taking hydroxyurea versus those not taking hydroxyurea. We retrospectively review ... Full text Link to item Cite

Partial splenectomy but not total splenectomy preserves immunoglobulin M memory B cells in mice.

Journal Article J Pediatr Surg · September 2011 PURPOSE: The mechanism by which partial splenectomy preserves splenic immune function is unknown. Immunoglobulin (Ig) M memory B cells are critical for the immune response against encapsulated bacteria and are reduced in asplenic patients, although it is u ... Full text Open Access Link to item Cite

Thermoregulation and thermography in neonatal physiology and disease.

Journal Article Biol Res Nurs · July 2011 INTRODUCTION: Infrared thermal imaging, or thermography, is a technique used to measure body surface temperature in the study of thermoregulation. Researchers are beginning to use this novel methodology to study cancer, peripheral vascular disease, and wou ... Full text Link to item Cite

Partial splenectomy for hereditary spherocytosis: a multi-institutional review.

Journal Article J Pediatr Surg · January 2011 BACKGROUND/PURPOSE: Partial splenectomy has emerged as a surgical option for selected children with hereditary spherocytosis, with the goal of reducing anemia while preserving splenic function. This multi-institutional study is the largest series to date e ... Full text Link to item Cite

Infrared thermal imaging (thermography) of the abdomen in extremely low birthweight infants.

Journal Article Journal of Surgical Radiology · October 2010 Introduction. Infrared thermal imaging (thermography) is a non-invasive method to measure skin temperature. The primary aim of this study was to examine the feasibility of thermography for the assessment of abdominal skin temperature in extremely low birth ... Link to item Cite

The Duke Abdominal Assessment Scale: initial experience.

Journal Article Expert Rev Gastroenterol Hepatol · October 2010 Plain abdominal radiographs are the current standard imaging modality of choice in the evaluation of patients with clinically suspected necrotizing enterocolitis. The time interval between radiographic exams varies with the severity of disease and may rang ... Full text Link to item Cite

Hereditary spherocytosis and partial splenectomy in children: review of surgical technique and the role of imaging.

Journal Article Pediatr Radiol · July 2010 The risks associated with total splenectomy, including overwhelming postsplenectomy infection, have led to an interest in the use of partial splenectomy as an alternative surgical option for children with congenital hemolytic anemias and hypersplenism. Par ... Full text Link to item Cite

Splenectomy and partial splenectomy improve hematopoietic stem cell engraftment in hypersplenic mice.

Journal Article J Pediatr Surg · June 2010 BACKGROUND: Hematopoietic stem cell (HSC) engraftment is delayed after transplantation in children with hypersplenism, increasing the morbidity and costs of care. Preliminary clinical data suggest that splenectomy before HSC transplantation may improve HSC ... Full text Open Access Link to item Cite

Protocolized approach to the management of congenital diaphragmatic hernia: benefits of reducing variability in care.

Journal Article J Pediatr Surg · June 2010 PURPOSE: Variable approaches to the care of infants with congenital diaphragmatic hernia (CDH) by multiple providers may contribute to inconsistent care. Our institution developed a comprehensive evidence-based protocol to standardize the management of CDH ... Full text Link to item Cite

Reply to letter to the editor by Fisk

Other Journal of Pediatric Surgery · May 1, 2010 Full text Cite

Preliminary observations of the use of high-frequency jet ventilation as rescue therapy in infants with congenital diaphragmatic hernia.

Journal Article J Pediatr Surg · April 2010 BACKGROUND/PURPOSE: Congenital diaphragmatic hernia (CDH) is associated with mortality of 10% to 50%. Several investigators have reported outcomes from centers using high-frequency oscillatory ventilation in their management of CDH, but there are no recent ... Full text Link to item Cite

Low volume is associated with worse patient outcomes for pediatric liver transplant centers.

Journal Article J Pediatr Surg · January 2010 BACKGROUND: An inverse association between hospital procedure volume and postoperative mortality has been demonstrated for a variety of pediatric surgical procedures. The objective of our study was to determine whether such an association exists for pediat ... Full text Link to item Cite

Radiographic predictors of disease severity in neonates and infants with necrotizing enterocolitis.

Journal Article AJR Am J Roentgenol · November 2009 OBJECTIVE: The objective of our study was to validate a radiographic scale, the Duke abdominal assessment scale (DAAS), as a tool for predicting the severity of disease in neonates and infants with suspected necrotizing enterocolitis (NEC). MATERIALS AND M ... Full text Link to item Cite

Use of allograft biopsies to assess thymopoiesis after thymus transplantation.

Journal Article J Immunol · May 1, 2008 Thymus allograft biopsies were performed in athymic infants with complete DiGeorge anomaly after thymus transplantation to assess whether the thymus allograft tissue was able to support thymopoiesis. Forty-four consecutive infants were treated with postnat ... Full text Link to item Cite

Partial splenectomy for hereditary spherocytosis.

Journal Article Pediatr Clin North Am · April 2008 The significant risks associated with total splenectomy have led to interest in the use of partial splenectomy as an alternative surgical therapy for children who have congenital hemolytic anemia. Partial splenectomy is designed to remove enough spleen to ... Full text Link to item Cite

Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly.

Journal Article J Pediatr Surg · March 2008 Partial splenectomy is an alternative to total splenectomy for the treatment of congenital hemolytic anemias (CHAs) in children, although the feasibility of this technique in the setting of massive splenomegaly is unknown. This study was designed to evalua ... Full text Link to item Cite

Dietary fat for infants with enterostomies.

Journal Article J Pediatr Surg · November 2007 BACKGROUND/PURPOSE: Infants with enterostomies frequently have signs of short bowel syndrome. Our goal was to assess the effect of dietary lipids on ostomy output and weight gain in infants with enterostomies. METHODS: We reviewed the medical records of 10 ... Full text Link to item Cite

Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia.

Journal Article J Hepatol · November 2007 BACKGROUND/AIMS: Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing. The objective of th ... Full text Link to item Cite

Congenital diaphragmatic hernia: a systematic review and summary of best-evidence practice strategies.

Journal Article J Perinatol · September 2007 OBJECTIVES: Recent reports suggest that specific care strategies improve survival of infants with congenital diaphragmatic hernia (CDH). This review presents details of care from centers reporting high rates of survival among CDH infants. STUDY DESIGN: We ... Full text Link to item Cite

Does this child have appendicitis?

Journal Article JAMA · July 25, 2007 CONTEXT: Evaluation of abdominal pain in children can be difficult. Rapid, accurate diagnosis of appendicitis in children reduces the morbidity of this common cause of pediatric abdominal pain. Clinical evaluation may help identify (1) which children with ... Full text Link to item Cite

Peer assessment of pediatric surgeons for potential risks of radiation exposure from computed tomography scans.

Journal Article J Pediatr Surg · July 2007 PURPOSE: Radiology literature reports potential cancer risk from radiation exposure from computed tomography (CT). We hypothesized that pediatric surgeons' knowledge of potential risks of radiation exposure from CT scan is limited. METHODS: We used an anon ... Full text Link to item Cite

Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants.

Journal Article Blood · May 15, 2007 The purpose of this study was to characterize a large group of infants with complete DiGeorge anomaly and to evaluate the ability of thymus transplantation to reconstitute immune function in these infants. DiGeorge anomaly is characterized by varying defec ... Full text Link to item Cite

Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice.

Journal Article AJR Am J Roentgenol · April 2007 OBJECTIVE: Adipose-derived stem cells are an alternative stem cell source for CNS therapies. The goals of the current study were to label adipose-derived stem cells with superparamagnetic iron oxide (SPIO) particles, to use MRI to guide the transplantation ... Full text Link to item Cite

Review of radiation risks from computed tomography: essentials for the pediatric surgeon.

Journal Article J Pediatr Surg · April 2007 BACKGROUND/PURPOSE: Over the past several years, increasing attention has been focused on the potential for radiation exposure from computed tomography (CT) for inducing the development of cancers. An understanding of these issues is important for the prac ... Full text Link to item Cite

Thoracoscopic resection of an apical extralobar pulmonary sequestration in an infant.

Journal Article J Laparoendosc Adv Surg Tech A · April 2007 Pulmonary sequestration is a form of bronchopulmonary-foregut malformation that is treated with surgical resection, either via a thoracotomy or the thoracoscopic approach. Apical extralobar pulmonary sequestrations are rare. We report a case of an apical p ... Full text Link to item Cite

Ingestion of unusual foreign bodies and malrotation: a "perfect storm".

Journal Article Pediatr Surg Int · October 2006 Management of foreign body ingestion is usually nonsurgical unless atypical foreign bodies or anatomical variants are suspected. The present article illustrates a case of atypical foreign bodies ingestion in the presence of intestinal malrotation. The pati ... Full text Link to item Cite

Electrocardiographic response to enzyme replacement therapy for Pompe disease.

Journal Article Genet Med · May 2006 PURPOSE: Electrocardiogram (ECG) abnormalities are universal in infantile Pompe disease or glycogen storage disease type II, a fatal genetic muscle disorder caused by deficiency of acid alpha-glucosidase (GAA). Hallmarks of this disease include a shortened ... Full text Link to item Cite

Ambulatory electrocardiogram analysis in infants treated with recombinant human acid alpha-glucosidase enzyme replacement therapy for Pompe disease.

Journal Article Genet Med · May 2006 PURPOSE: Infantile Pompe disease is caused by deficiency of lysosomal acid alpha-glucosidase. Trials with recombinant human acid alpha-glucosidase enzyme replacement therapy (ERT) show a decrease in left ventricular mass and improved function. We evaluated ... Full text Link to item Cite

Splenectomy

Chapter · January 1, 2006 The first attempt to define the role of the spleen was made by Hippocrates around 400BC, who taught that the spleen “drew the watery part of food from the stomach.” Aristotle believed that the spleen had no function, and the ancient Greeks felt that the we ... Full text Cite

Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease.

Journal Article Pediatr Blood Cancer · October 15, 2005 The risk of second malignancies after successful treatment for Hodgkin disease can be considerable. The most common malignancies are solid tumors arising in irradiated sites, such as the breast and thyroid gland after mantle field radiation. Sarcomas and o ... Full text Link to item Cite

Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34.

Journal Article Blood · July 1, 2005 A broad range of hematopoietic stem cells and progenitors reside within a fraction of umbilical cord blood (UCB) that exhibits low light scatter properties (SSC(lo)) and high expression of aldehyde dehydrogenase (ALDH(br)). Many SSC(lo) ALDH(br) cells coex ... Full text Link to item Cite

A study of 11,003 patients with hypertrophic pyloric stenosis and the association between surgeon and hospital volume and outcomes.

Journal Article J Pediatr Surg · June 2005 AIM: The availability of large clinical databases allows for careful evaluation of surgical practices, indicators of quality improvement, and cost. We used a large clinical database to compare the effect of surgeon and hospital volume for the care of child ... Full text Link to item Cite

Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells.

Journal Article Curr Drug Targets · February 2005 There is growing evidence to suggest that reservoirs of stem cells may reside in several types of adult tissue. These cells may retain the potential to transdifferentiate from one phenotype to another, presenting exciting possibilities for cellular therapi ... Full text Link to item Cite

Partial splenectomy before a hematopoietic stem cell transplantation in children.

Journal Article J Pediatr Surg · January 2005 UNLABELLED: Hematopoietic stem cell (HSC) engraftment is delayed in children with hypersplenism, and splenectomy may improve HSC engraftment. However, the use of total splenectomy in children is limited because of concerns for postsplenectomy sepsis. In th ... Full text Link to item Cite

Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerations.

Journal Article J Pediatr Surg · November 2004 BACKGROUND/PURPOSE: Complete DiGeorge syndrome results in the absence of functional T cells. Our program supports the transplantation of allogeneic thymic tissue in infants with DiGeorge syndrome to reconstitute immune function. This study reviews the mult ... Full text Link to item Cite

Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome.

Journal Article Blood · October 15, 2004 Complete DiGeorge syndrome is a fatal congenital disorder characterized by athymia, hypoparathyroidism, and heart defects. Less than half of patients are 22q11 hemizygous. The goal of this study was to assess if immune suppression followed by postnatal thy ... Full text Link to item Cite

Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells.

Journal Article Exp Neurol · June 2004 Neural tissue has limited capacity for intrinsic repair after injury, and the identification of alternate sources of neuronal stem cells has broad clinical potential. Preliminary studies have demonstrated that adipose-derived adult stromal (ADAS) cells are ... Full text Link to item Cite

Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases.

Journal Article J Allergy Clin Immunol · April 2004 BACKGROUND: Five patients with DiGeorge syndrome presented with infections, skin rashes, and lymphadenopathy after the newborn period. T-cell counts and function varied greatly in each patient. Initial laboratory testing did not suggest athymia in these pa ... Full text Link to item Cite

Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients.

Journal Article Blood · August 1, 2003 Complete DiGeorge syndrome is a fatal condition in which infants have no detectable thymus function. The optimal treatment for the immune deficiency of complete DiGeorge syndrome has not been determined. Safety and efficacy of thymus transplantation were e ... Full text Link to item Cite

Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children.

Journal Article Ann Surg · February 2003 Featured Publication OBJECTIVE: To assess the role of partial splenectomy for symptomatic children with various congenital hemolytic anemias. SUMMARY BACKGROUND DATA: The use of total splenectomy for symptomatic children with congenital hemolytic anemias is restricted by conce ... Full text Link to item Cite

A cost and outcomes comparison of a novel integrated pediatric air and ground transportation system.

Journal Article J Am Coll Surg · December 2002 Featured Publication BACKGROUND: The purpose of this study is to compare air transportation of critically ill pediatric patients with a mixed air-ground transportation system by evaluating timeliness, safety, and cost. The setting was a tertiary care "hub" center with three ou ... Full text Link to item Cite

Neurogenic differentiation of murine and human adipose-derived stromal cells.

Journal Article Biochem Biophys Res Commun · June 7, 2002 Featured Publication The identification of cells capable of neuronal differentiation has great potential for cellular therapies. We examined whether murine and human adipose-derived adult stem (ADAS) cells can be induced to undergo neuronal differentiation. We isolated ADAS ce ... Full text Link to item Cite

Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo.

Journal Article Biochem Biophys Res Commun · January 18, 2002 Featured Publication Articular cartilage exhibits little intrinsic repair capacity, and new tissue engineering approaches are being developed to promote cartilage regeneration using cellular therapies. The goal of this study was to examine the chondrogenic potential of adipose ... Full text Link to item Cite

Results of a pilot trial comparing prolonged intravenous antibiotics with sequential intravenous/oral antibiotics for children with perforated appendicitis.

Journal Article Arch Surg · December 2001 Featured Publication HYPOTHESIS: For children with perforated appendicitis, the use of a prolonged course of intravenous (i.v.) antibiotics is equivalent to a short course of i.v. antibiotics followed by sequential conversion to oral (PO) antibiotics. DESIGN: Prospective, rand ... Full text Link to item Cite

Management of cholelithiasis in pediatric patients who undergo bone marrow transplantation.

Journal Article J Pediatr Surg · January 2001 PURPOSE: The aim of this study was to determine the incidence, risk factors, and proper management for asymptomatic cholelithiasis in children undergoing bone marrow transplantation (BMT). METHODS: The authors reviewed retrospectively the records of 575 ch ... Full text Link to item Cite

Vascular control for resection of suprahepatic intracaval Wilms' tumor: technical considerations.

Journal Article J Pediatr Surg · December 2000 Featured Publication The surgical resection of Wilms' tumor can be complicated by tumor thrombus extension into the inferior vena cava. In cases of suprahepatic Wilms' tumor thrombus that may extend into the right atrium, a median sternotomy and cardiopulmonary bypass (CPB) ar ... Full text Link to item Cite

Multilineage hematopoietic development from umbilical cord blood cells with high aldehyde dehydrogenase activity

Conference Blood · December 1, 2000 We have previously described the isolation of early hematopoietic progenitors based on their high expression of aldehyde dehydrogenase (ALDHbr cells; Proc. Nail. Acad. Sci. USA 91:9118). In those studies, the ALDH" cells isolated from umbilical cord blood ... Cite

Juvenile papillomatosis of the breast in male infants: two case reports.

Journal Article Pediatr Surg Int · 2000 Featured Publication Juvenile papillomatosis of the breast ("Swiss cheese disease") is a benign localized proliferative condition of the breast which occurs almost exclusively in young adult women. Patients with this lesion often have a family history of breast carcinoma, and ... Full text Link to item Cite

Current management of pediatric inflammatory bowel disease.

Journal Article Semin Pediatr Surg · November 1999 Inflammatory bowel disease (IBD) is a relatively rare condition of childhood, although the wide range of presenting complaints, scope of complications, and choices of therapy for this condition make it particularly difficult to treat in children. Novel app ... Full text Link to item Cite

Transplantation of thymus tissue in complete DiGeorge syndrome.

Journal Article N Engl J Med · October 14, 1999 BACKGROUND: The DiGeorge syndrome is a congenital disorder that affects the heart, parathyroid glands, and thymus. In complete DiGeorge syndrome, patients have severely reduced T-cell function. METHODS: We treated five infants (age, one to four months) wit ... Full text Link to item Cite

Does early ultrasonography affect management of pediatric appendicitis? A prospective analysis.

Journal Article J Pediatr Surg · May 1999 BACKGROUND: Appendicitis remains a difficult diagnosis in children. Ultrasonography is increasingly used for the diagnosis of appendicitis, although the proper clinical role for this test remains unclear. METHODS: To evaluate the clinical utility of ultras ... Full text Link to item Cite

Care of the surgical intensive care nursery graduate. The primary care pediatrician's perspective.

Journal Article Pediatr Clin North Am · December 1998 Care of the intensive care nursery graduate may be quite challenging. It is important that primary care pediatricians become familiar with the complications unique to surgical patients so that they may properly prepare and educate parents and provide appro ... Full text Link to item Cite

Fluid therapy for the pediatric surgical patient.

Journal Article Pediatr Clin North Am · August 1998 The fluid management of the pediatric surgical patient is a crucial aspect of surgical care. This article reviews the fundamental physiology of fluid replacement in children and highlights how standard formulas for fluid therapy can be modified to account ... Full text Link to item Cite

The biology and ethics of banking fetal liver hematopoietic stem cells for in utero transplantation.

Journal Article J Pediatr Surg · February 1998 BACKGROUND/PURPOSE: Transplantation of fetal liver hematopoietic stem cells (HSCs) in utero has the potential to treat a variety of hematologic, immunologic, and metabolic diseases. One prerequisite for broad clinical application is the establishment of a ... Full text Link to item Cite

Morbid prognostic features in patients with chronic liver failure undergoing nonhepatic surgery.

Journal Article Arch Surg · August 1997 BACKGROUND: Although the risk of portal decompression surgery is accurately predicted by objective scoring systems (Child classification and Pugh score), few useful prognostic criteria exist regarding nonhepatic surgery in patients with chronic liver failu ... Full text Link to item Cite

Ruptured Salmonella mycotic aneurysm of the extracranial carotid artery.

Journal Article Ann Vasc Surg · July 1997 Mycotic aneurysms of the extracranial carotid artery are rare and difficult to diagnose and can lead to significant medical morbidity. Treatment of these lesions requires expert surgical management and necessitates an assiduous search for an underlying sou ... Full text Link to item Cite

In utero hematopoietic stem cell transplants prolong survival of postnatal kidney transplantation in monkeys.

Journal Article J Pediatr Surg · July 1997 The authors hypothesized that in utero transplantation of T-cell-depleted paternal marrow into rhesus monkey fetuses would induce tolerance to postnatal kidney grafts from the marrow donor. T-cell-depleted paternal bone marrow was transplanted intraperiton ... Full text Link to item Cite

Familial diaphragmatic agenesis: an autosomal-recessive syndrome with a poor prognosis.

Journal Article J Pediatr Surg · February 1997 Diaphragmatic agenesis is a severe form of congenital diaphragmatic hernia for which an autosomal recessive form of inheritance has been proposed. The authors report six families with 13 pregnancies with diaphragmatic agenesis in which inheritance followed ... Full text Link to item Cite

Enhancement of human hematopoiesis by mast cell growth factor in human-sheep chimeras created by the in utero transplantation of human fetal hematopoietic cells.

Journal Article Exp Hematol · March 1995 We have previously described a unique model of long-term, multilineage, human hematopoietic chimerism in sheep created by the in utero transplantation of human hematopoietic stem cells (HSC) into pre-immune fetal lambs. In this study, we examined the effec ... Link to item Cite

Massive thymic hyperplasia: characterization of a rare mediastinal mass.

Journal Article J Pediatr Surg · December 1994 Thymic hyperplasia is a rare cause of an anterior mediastinal mass in children. True thymic hyperplasia is characterized by massive thymic hypertrophy with retention of normal thymic architecture, and must be distinguished from more commonly seen tumors of ... Full text Link to item Cite

An effective strategy for decontamination, ex vivo expansion, and storage of human fetal liver hematopoietic stem cells.

Journal Article Transplant Proc · December 1994 The transplantation of human fetal tissue has the potential to cure a variety of life-threatening diseases. The strategy for procurement, quality control, and functional assessment of human fetal liver HSC may prove useful for the transplantation of other ... Link to item Cite

Congenital cystic adenomatoid malformation: a sheep model of fetal hydrops.

Journal Article J Pediatr Surg · May 1994 Congenital cystic adenomatoid malformation (CCAM) can be diagnosed in utero. Nonimmune hydrops associated with CCAM is a predictor of fetal demise. Fetuses with prenatally diagnosed large CCAM tumors and hydrops have undergone successful in utero resection ... Full text Link to item Cite

Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep.

Journal Article J Clin Invest · March 1994 We previously reported on the successful engraftment and long-term multilineage expression (erythroid, myeloid, lymphoid) of human fetal liver hematopoietic stem cells in sheep after transplantation in utero. That the engraftment of long-term repopulating ... Full text Link to item Cite

Chronic fetal vascular access.

Journal Article Lancet · October 30, 1993 Intensive management of the fetus is limited by our inability to achieve access to the fetal circulation. Using laparoscopic surgery, we can maintain long-term access to the fetal circulation by extra-amniotic catheterisation of chorionic vessels in third- ... Full text Link to item Cite

Prenatal diagnosis: essentials for the pediatric surgeon.

Journal Article Semin Pediatr Surg · May 1993 Prenatal diagnosis is a rapidly growing field that has supported new treatments for the developing fetus. Improved methods of diagnosing anatomic, biochemical, and molecular defects of the fetus have fostered a parallel growth of better techniques of fetal ... Link to item Cite

Effect of xenogeneic chimerism in a human/sheep model on natural antibody.

Journal Article J Surg Res · April 1993 Xenogeneic transplantation is a potential solution to the severe shortage of donor organs for clinical transplantation. The primary limitation to xenogeneic transplantation between widely disparate species is hyperacute rejection, which is triggered by the ... Full text Link to item Cite

Bacterial and fungal contamination of human fetal liver collected transvaginally for hematopoietic stem cell transplantation.

Journal Article Fetal Diagn Ther · 1993 Transplantation of fetal hematopoietic stem cells is a new therapy for fetuses diagnosed in utero with inherited disorders. However, prior to transplantation of fetal stem cells, the cells must be free of microbial contamination. In order to investigate th ... Full text Link to item Cite

Evaluation of Nissen fundoplication in neurologically impaired children.

Journal Article J Pediatr Surg · June 1991 The value of performing Nissen fundoplication in neurologically impaired children is a controversial issue. To evaluate the benefit of fundoplication in these children, hospital records were reviewed for 77 children who underwent fundoplication for gastroe ... Full text Link to item Cite

Phenothiazines in murine African trypanosomiasis.

Journal Article Trans R Soc Trop Med Hyg · 1987 Full text Link to item Cite

Platelet alpha-2-adrenergic dysfunction in negative symptom schizophrenia: a preliminary study.

Journal Article Biol Psychiatry · May 1985 The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patient ... Full text Link to item Cite

Platelet alpha 2-adrenergic receptors in schizophrenic patients before and after phenothiazine treatment.

Journal Article Psychiatry Res · May 1984 The specific binding to isolated platelet membranes of 3H-clonidine, an alpha 2-adrenergic receptor partial agonist, and 3H-yohimbine, an alpha 2-adrenergic receptor antagonist, was measured in male, drug-free schizophrenic patients. The maximum number of ... Full text Link to item Cite