Scholars@Duke
Robert Ellis Reiman Jr.

Robert Ellis Reiman Jr.

Associate Professor of Radiology
Radiology
robert.reiman@duke.edu
Box 3155 Med Ctr, Durham, NC
409 Elf Street, Durham, NC 27705
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Selected Publications

Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers.

Journal Article Sci Rep · February 22, 2022 Radiopharmaceutical therapy (RPT) is an attractive strategy for treatment of disseminated cancers including those overexpressing the HER2 receptor including breast, ovarian and gastroesophageal carcinomas. Single-domain antibody fragments (sdAbs) exemplifi ... Full text Link to item Cite

Seven-Pinhole Versus Single-Pinhole SPECT for Thyroid Imaging

Conference 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020 · January 1, 2020 To compare 7-pinhole and single-pinhole SPECT thyroid imaging under conditions of equal total detector area. A phantom was generated using XCAT software. Trajectories of 7-pinhole and single-pinhole detectors were developed for 2 scenarios: (i) minimum rad ... Full text Cite

Improved Dose Estimates for Fluoroscopically Guided Lumbar Epidural Injections.

Journal Article Pain Med · May 1, 2019 OBJECTIVE: The goal of the study was to determine the potential impact of system inaccuracies and table attenuation on fluoroscope-reported dose values. DESIGN: An Institutional Review Board-approved study was conducted to collect detailed acquisition and ... Full text Link to item Cite

Predictors of Survival in 211 Patients with Stage IV Pulmonary and Gastroenteropancreatic MIBG-Positive Neuroendocrine Tumors Treated with 131I-MIBG.

Journal Article J Nucl Med · November 2018 This retrospective analysis identifies predictors of survival in a cohort of patients with meta-iodobenzylguanidine (MIBG)-positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with 131I-MIBG therapy, to inform tre ... Full text Open Access Link to item Cite

Synthesis and Preliminary Evaluation of 5-[18F]fluoroleucine.

Journal Article Curr Radiopharm · 2017 BACKGROUND: Amino acid transporters, such as LAT1, are overexpressed in aggressive prostate and breast carcinomas, directly influencing pathways of growth and proliferation. OBJECTIVE: The purpose of this study was to synthesize and characterize a novel 18 ... Full text Open Access Link to item Cite

A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance.

Journal Article SAGE Open Med Case Rep · 2017 In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method ... Full text Open Access Link to item Cite

Lifetime Attributable Risk of Cancer From Radiation Exposure During Parathyroid Imaging: Comparison of 4D CT and Parathyroid Scintigraphy.

Journal Article AJR Am J Roentgenol · May 2015 OBJECTIVE: The purpose of this study is to measure the organ doses and effective dose (ED) for parathyroid 4D CT and scintigraphy and to estimate the lifetime attributable risk of cancer incidence associated with imaging. MATERIALS AND METHODS: Organ radia ... Full text Link to item Cite

Medical imaging safety in the developing world

Chapter · October 1, 2014 Attention to matters of safety is important in any imaging facility. In the context of the developing world, limited resources may complicate the attempt to set up and operate an imaging facility with the highest standards of safety, but it is nonetheless ... Full text Cite

Cumulative radiation exposure and cancer risk estimation in children with heart disease.

Journal Article Circulation · July 8, 2014 BACKGROUND: Children with heart disease are frequently exposed to imaging examinations that use ionizing radiation. Although radiation exposure is potentially carcinogenic, there are limited data on cumulative exposure and the associated cancer risk. We ev ... Full text Link to item Cite

The effect of dose heterogeneity on radiation risk in medical imaging.

Journal Article Radiat Prot Dosimetry · June 2013 Featured Publication The current estimations of risk associated with medical imaging procedures rely on assessing the organ dose via direct measurements or simulation. The dose to each organ is assumed to be homogeneous. To take into account the differences in radiation sensit ... Full text Link to item Cite

Informed consent in human research: what to say and how to say it.

Journal Article Health Phys · February 2013 Featured Publication To ensure that the possibility of harm to human research subjects is minimized, clinical trials and other research protocols are subject to oversight by Institutional Review Boards (IRBs). IRBs require that subjects be fully informed about the real or pote ... Full text Link to item Cite

Comparison of current and past surgical smoke control practices.

Journal Article AORN J · March 2012 In 2010, we teamed with AORN to repeat a simple web-based survey on surgical smoke control practices first conducted in 2007. This survey of AORN members assessed the level of compliance with established surgical smoke control measures (ie, use of wall suc ... Full text Link to item Cite

Nuclear medicine

Chapter · January 19, 2012 Cite

Nuclear medicine: Case 14

Chapter · January 19, 2012 Cite

Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.

Journal Article Curr Radiopharm · January 2012 PURPOSE: Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation. The purpose of this study is to report the novel synthesis of a chloroqui ... Full text Link to item Cite

Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers.

Journal Article Sci Rep · February 22, 2022 Radiopharmaceutical therapy (RPT) is an attractive strategy for treatment of disseminated cancers including those overexpressing the HER2 receptor including breast, ovarian and gastroesophageal carcinomas. Single-domain antibody fragments (sdAbs) exemplifi ... Full text Link to item Cite

Seven-Pinhole Versus Single-Pinhole SPECT for Thyroid Imaging

Conference 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2020 · January 1, 2020 To compare 7-pinhole and single-pinhole SPECT thyroid imaging under conditions of equal total detector area. A phantom was generated using XCAT software. Trajectories of 7-pinhole and single-pinhole detectors were developed for 2 scenarios: (i) minimum rad ... Full text Cite

Improved Dose Estimates for Fluoroscopically Guided Lumbar Epidural Injections.

Journal Article Pain Med · May 1, 2019 OBJECTIVE: The goal of the study was to determine the potential impact of system inaccuracies and table attenuation on fluoroscope-reported dose values. DESIGN: An Institutional Review Board-approved study was conducted to collect detailed acquisition and ... Full text Link to item Cite

Predictors of Survival in 211 Patients with Stage IV Pulmonary and Gastroenteropancreatic MIBG-Positive Neuroendocrine Tumors Treated with 131I-MIBG.

Journal Article J Nucl Med · November 2018 This retrospective analysis identifies predictors of survival in a cohort of patients with meta-iodobenzylguanidine (MIBG)-positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with 131I-MIBG therapy, to inform tre ... Full text Open Access Link to item Cite

Synthesis and Preliminary Evaluation of 5-[18F]fluoroleucine.

Journal Article Curr Radiopharm · 2017 BACKGROUND: Amino acid transporters, such as LAT1, are overexpressed in aggressive prostate and breast carcinomas, directly influencing pathways of growth and proliferation. OBJECTIVE: The purpose of this study was to synthesize and characterize a novel 18 ... Full text Open Access Link to item Cite

A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance.

Journal Article SAGE Open Med Case Rep · 2017 In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method ... Full text Open Access Link to item Cite

Lifetime Attributable Risk of Cancer From Radiation Exposure During Parathyroid Imaging: Comparison of 4D CT and Parathyroid Scintigraphy.

Journal Article AJR Am J Roentgenol · May 2015 OBJECTIVE: The purpose of this study is to measure the organ doses and effective dose (ED) for parathyroid 4D CT and scintigraphy and to estimate the lifetime attributable risk of cancer incidence associated with imaging. MATERIALS AND METHODS: Organ radia ... Full text Link to item Cite

Medical imaging safety in the developing world

Chapter · October 1, 2014 Attention to matters of safety is important in any imaging facility. In the context of the developing world, limited resources may complicate the attempt to set up and operate an imaging facility with the highest standards of safety, but it is nonetheless ... Full text Cite

Cumulative radiation exposure and cancer risk estimation in children with heart disease.

Journal Article Circulation · July 8, 2014 BACKGROUND: Children with heart disease are frequently exposed to imaging examinations that use ionizing radiation. Although radiation exposure is potentially carcinogenic, there are limited data on cumulative exposure and the associated cancer risk. We ev ... Full text Link to item Cite

The effect of dose heterogeneity on radiation risk in medical imaging.

Journal Article Radiat Prot Dosimetry · June 2013 Featured Publication The current estimations of risk associated with medical imaging procedures rely on assessing the organ dose via direct measurements or simulation. The dose to each organ is assumed to be homogeneous. To take into account the differences in radiation sensit ... Full text Link to item Cite

Informed consent in human research: what to say and how to say it.

Journal Article Health Phys · February 2013 Featured Publication To ensure that the possibility of harm to human research subjects is minimized, clinical trials and other research protocols are subject to oversight by Institutional Review Boards (IRBs). IRBs require that subjects be fully informed about the real or pote ... Full text Link to item Cite

Comparison of current and past surgical smoke control practices.

Journal Article AORN J · March 2012 In 2010, we teamed with AORN to repeat a simple web-based survey on surgical smoke control practices first conducted in 2007. This survey of AORN members assessed the level of compliance with established surgical smoke control measures (ie, use of wall suc ... Full text Link to item Cite

Nuclear medicine

Chapter · January 19, 2012 Cite

Nuclear medicine: Case 14

Chapter · January 19, 2012 Cite

Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.

Journal Article Curr Radiopharm · January 2012 PURPOSE: Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation. The purpose of this study is to report the novel synthesis of a chloroqui ... Full text Link to item Cite

Radiation protection of technologists and ancillary personnel

Journal Article · December 1, 2011 Because PET-CT employs both radioactive material and x-rays in the same imaging suite, it presents special challenges for radiation protection. Diligent application of the As Low As Reasonably Achievable (ALARA) principle can minimize radiation doses to PE ... Full text Cite

Radiation dose estimates of [125I] and [131I] – iodoquine, a putative radiotracer targeting cells with high ALDH expression

Conference Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2009 Cite

Results of a survey on current surgical smoke control practices.

Journal Article AORN J · April 2008 Researchers at Duke University Medical Center, Durham, NC, conducted a simple, web-based survey of AORN members to evaluate surgical smoke control practices. Survey respondents from various medical specialties and facilities throughout North America indica ... Full text Link to item Cite

Radiation dose from contemporary cardiothoracic multidetector CT protocols with an anthropomorphic female phantom: implications for cancer induction.

Journal Article Radiology · December 2007 Featured Publication PURPOSE: To measure prospectively and directly both organ dose and effective dose (ED) for adult cardiac and pulmonary computed tomographic (CT) angiography by using current clinical protocols for 64-detector CT in an anthropomorphic female phantom and to ... Full text Link to item Cite

Radiation dose to the female breast from 16-MDCT body protocols.

Journal Article AJR Am J Roentgenol · June 2006 Featured Publication OBJECTIVE: The objective of our study was to determine the radiation dose to the female breast from current 16-MDCT body examinations. MATERIALS AND METHODS: Metal oxide semiconductor field effect transistor (MOSFET) detectors were placed in four quadrants ... Full text Link to item Cite

Radiation dose to the fetus from body MDCT during early gestation.

Journal Article AJR Am J Roentgenol · March 2006 Featured Publication OBJECTIVE: The purpose of our study was to determine radiation dose to the fetus at early gestation when contemporary MDCT scanners are used for common clinical indications. MATERIALS AND METHODS: Anthropomorphic phantoms were constructed to reflect a preg ... Full text Link to item Cite

TU‐B‐I‐611‐01: Releasing Nuclear Medicine Patients to the Public: Dose Computations and Discharge Instructions

Journal Article Medical Physics · January 1, 2005 Thousands of patients are treated annually in the United States with iodine‐131 for various medical conditions. Prior to 1996, patients treated with more than 30 millicuries of iodine‐131 were required to be hospitalized in a private room until their iodin ... Full text Cite

Pharmacokinetics and radiation dosimetry of 18F-fluorocholine.

Journal Article J Nucl Med · January 2002 Featured Publication UNLABELLED: 18F-Fluorocholine (fluoromethyl-dimethyl-2-hydroxyethylammonium [FCH]) has been developed as an oncologic probe for PET. This study evaluates the kinetics and radiation dosimetry of 18F-FCH using murine and human biodistribution data. METHODS: ... Link to item Cite

Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.

Journal Article J Nucl Med · December 2001 UNLABELLED: Elevated levels of choline (trimethyl-2-hydroxyethylammonium) and choline kinase (CK) activity in neoplasms have motivated the development of positron-labeled choline analogs for noninvasive detection of cancer using PET. The aim of this study ... Link to item Cite

Intrathecal 131I-labeled antitenascin monoclonal antibody 81C6 treatment of patients with leptomeningeal neoplasms or primary brain tumor resection cavities with subarachnoid communication: phase I trial results.

Journal Article Clin Cancer Res · June 1996 We aimed to determine the maximum tolerated dose (MTD) of 131I-labeled 81C6 in patients with leptomeningeal neoplasms or brain tumor resection cavities with subarachnoid communication and to identify any objective responses. 81C6 is a murine IgG monoclonal ... Link to item Cite

Localization of technetium-99m-sestamibi in diffuse myelodysplastic processes.

Journal Article J Nucl Med · March 1996 Featured Publication Link to item Cite

Prognostic importance of restaging gallium scans following induction chemotherapy for advanced Hodgkin's disease.

Journal Article J Clin Oncol · February 1994 PURPOSE: This study was intended to assess the ability of restaging gallium scanning to distinguish between patients with residual radiographic abnormalities who still have active Hodgkin's disease (HD) and those who are truly complete responders. Early id ... Full text Link to item Cite

Imaging studies of patients with malignant fibrous histiocytoma using C-11-alpha-aminoisobutyric acid (AIB).

Journal Article Clin Nucl Med · January 1987 Alpha-aminoisobutyric acid (AIB), a synthetic, nonmetabolized amino acid which is rapidly transported into viable cells by the A-type or alanine-preferring amino acid transport system, has been labeled with the short-lived, positron-emitting radionuclide c ... Full text Link to item Cite

Imaging of human tumors and organs with N-13-labeled L-methionine.

Journal Article Am J Physiol Imaging · 1986 The work described herein is the first reported use of nitrogen-13-labeled L-methionine in human subjects. Three volunteers and 14 patients with a variety of solid tumors were scanned after intravenous administration of L-(N-13) methionine. In both volunte ... Link to item Cite

Use of sodium chromate Cr51 in diagnosing childhood idiopathic pulmonary hemosiderosis.

Journal Article Am J Dis Child · August 1984 The diagnosis of idiopathic pulmonary hemosiderosis (IPH) may be elusive. A 6-year-old boy had microcytic hypochromic anemia and a hemolytic component. Hemosiderin-laden macrophages were not found in the gastric aspirate. He had no pulmonary signs or sympt ... Full text Link to item Cite

Intratumoral consumption of indium-111 labeled platelets in a patient with hemangiomatosis and intravascular coagulation (Kasabach-Merritt syndrome).

Journal Article Cancer · December 15, 1983 Previous studies regarding sites of platelet destruction in patients with the Kasabach-Merritt syndrome are conflicting. The authors recently studied an adult patient with multiple large hemangiomata, thrombocytopenia, and intravascular coagulation by exte ... Full text Link to item Cite

Quantitative scanning of soft-tissue sarcomas with nitrogen-13-labeled L-glutamate.

Journal Article Cancer Invest · 1983 Nitrogen-13-L-glutamate, a labeled amino acid enzymatically synthesized from cyclotron-produced N-13 ammonia and alpha-ketoglutaric acid, was used as an imaging agent in 14 patients with soft-tissue sarcomas. Concentration of nitrogen-13 label within the s ... Full text Link to item Cite

Imaging of brain tumors after administration of L-(N-13)glutamate: concise communication.

Journal Article J Nucl Med · August 1982 Featured Publication Cyclotron-produced L-(N-13)glutamate was used to visualize malignant intracranial tumors in 12 pediatric patients who had evidence of recurrent disease as documented by computed transaxial tomography (TCT). Imaging was performed using a rectilinear scanner ... Link to item Cite

Scanning with L-(13 N) glutamate: Assessment of the response to chemotherapy of a patient with embryonal rhabdomyosarcoma.

Journal Article Am J Clin Oncol · June 1982 The use of (13) N-labeled L-glutamate as an imaging agent in a patient with embryonal rhabdomyosarcoma is described. Localization of (13)N in a large, poorly defined tumor of the left pectoral region was seen, and clinically occult right axilliary metastas ... Link to item Cite

Imaging of primary Ewing sarcoma with 13N-L-glutamate.

Journal Article Radiology · February 1982 Featured Publication Eleven patients with untreated primary Ewing sarcoma were studied with intravenously administered 13N-labeled L-glutamate. Seven were repeatedly scanned during chemotherapy using this agent and 99mTc-methylene diphosphonate (99mTc-MDP). The untreated prima ... Full text Link to item Cite

Quotient imaging with N-13 L-glutamate in osteogenic sarcoma: correlation with tumor viability.

Journal Article Cancer · November 1, 1981 Featured Publication An investigation was performed to correlate the regional uptake of N-13 L-glutamate with histologic changes in tumor tissue in patients undergoing adjuvant chemotherapy for osteogenic sarcoma. A parametric image was produced by calculating the ratio of N-1 ... Full text Link to item Cite

Tissue distribution studies of [18F]haloperidol, [18F]-beta-(4-fluorobenzoyl)propionic acid, and [82Br]bromperidol by external scintigraphy.

Journal Article J Pharm Sci · September 1981 Tissue distribution studies of [18F]haloperidol and [82Br]bromperidol, two potent neuroleptic drugs, were performed in rats by serial sacrifice. The usefulness of external scintigraphy in obtaining tissue distribution data in large animals is demonstrated ... Full text Link to item Cite

N-13-LABELED L-AMINO-ACIDS - ENZYMATIC SYNTHESES AND METABOLIC STUDIES

Journal Article ADVANCES IN CHEMISTRY SERIES · January 1, 1981 Link to item Cite

Imaging of the human heart after administration of L-(N-13)glutamate.

Journal Article J Nucl Med · October 1980 In normal volunteers and cancer patients, studies using L-(N-13)glutamate as an imaging agent showed localization of N-13 activity in the heart. Other organs that were well visualized include the liver, pancreas, and salivary glands. In ten subjects the av ... Link to item Cite

13N,15N isotope and kinetic evidence against hyponitrite as an intermediate in dentrification.

Journal Article J Biol Chem · June 10, 1980 13N- and 15N-labeling experiments were carried out with Paracoccus denitrificans, grown anaerobically on nitrate, to determine whether hyponitrite might be an obligatory intermediate in denitrification and a precursor of nitrous oxide. From experiments des ... Link to item Cite

Quantitative scanning of osteogenic sarcoma with nitrogen-13-labeled L-glutamate.

Journal Article J Nucl Med · July 1979 N-13 L-glutamate was used to image an osteogenic sarcoma in a 9-year-old patient. Serial quantitative measurements of the amount of N-13 taken up by the primary tumor showed a decrease of 40% after 10 wk of chemotherapy. Blood-clearance data obtained from ... Link to item Cite

The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia.

Journal Article J Clin Invest · March 1979 Featured Publication The cyclotron-produced radionuclide, 13N, was used to label ammonia and to study its metabolism in a group of 5 normal subjects and 17 patients with liver disease, including 5 with portacaval shunts and 11 with encephalopathy. Arterial ammonia levels were ... Full text Link to item Cite