Scholars@Duke
Rong Jiang

Rong Jiang

Assistant Professor in Head and Neck Surgery & Communication Sciences
Head & Neck Surgical Oncology
rong.jiang@duke.edu
40 Duke Medicine Circle, DUMC 3805, Durham, NC 27710

Selected Publications

Predicting physical activity by the personality styles of the five-factor model.

Journal Article Health Psychol · October 2024 OBJECTIVE: Low neuroticism, high extraversion, and high conscientiousness are related to physical activity (PA). We tested whether the small size and heterogeneity of these relationships result because personality traits influence one another as well as be ... Full text Link to item Cite

Improving Health Literacy of Elective Procedures in Pediatric Otolaryngology.

Journal Article Otolaryngol Head Neck Surg · August 2024 OBJECTIVE: To identify if the addition of supplementary material, such as video or written resources, to the consent process, can improve a patient's or guardian's health literacy in pediatric otolaryngology. STUDY DESIGN: Prospective randomized crossover ... Full text Link to item Cite

Genome-Wide Genetic Analysis of Dropout in a Controlled Exercise Intervention in Sedentary Adults With Overweight or Obesity and Cardiometabolic Disease.

Journal Article Ann Behav Med · April 11, 2024 BACKGROUND: Despite the benefits of exercise, many individuals are unable or unwilling to adopt an exercise intervention. PURPOSE: The purpose of this analysis was to identify putative genetic variants associated with dropout from exercise training interve ... Full text Open Access Link to item Cite

Malnutrition and Adverse Outcomes After Surgery for Head and Neck Cancer.

Journal Article JAMA Otolaryngol Head Neck Surg · January 1, 2024 IMPORTANCE: Patients with head and neck cancer (HNC) have an increased risk of malnutrition, partly due to disease location and treatment sequelae. Although malnutrition is associated with adverse outcomes, there is little data on the extent of outcomes an ... Full text Open Access Link to item Cite

Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses.

Journal Article Alzheimers Dement · July 2023 INTRODUCTION: Our understanding of the genetic predisposition for age-at-onset (AAO) of Alzheimer's disease (AD) is limited. Here, we sought to identify genes modifying AAO and examined whether any have sex-specific effects. METHODS: Genome-wide associatio ... Full text Link to item Cite

Integrated Health Maintenance Reminders for Improved HPV Vaccine Administration: Toward Improvements in Completion Disparities.

Journal Article Otolaryngol Head Neck Surg · July 2023 OBJECTIVE: To evaluate the effect of a health maintenance reminder (HMR) on human papillomavirus (HPV) vaccine administration and completion across different age, insurance, and race cohorts. STUDY DESIGN: Retrospective pre-post analysis. SETTING: Academic ... Full text Link to item Cite

Effect of behavioral weight-loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial.

Journal Article Obesity (Silver Spring) · February 2023 OBJECTIVE: This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12-month behavioral weight-loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers. M ... Full text Open Access Link to item Cite

The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes.

Journal Article Clin Epigenetics · December 3, 2022 BACKGROUND: Epigenetic age is a DNA methylation-based biomarker of aging that is accurate across the lifespan and a range of cell types. The difference between epigenetic age and chronological age, termed age acceleration (AA), is a strong predictor of lif ... Full text Open Access Link to item Cite

Combining quantitative and survival trait analyses identifies novel general and sex-specific genes for age-at-onset of Alzheimer’s disease

Journal Article Alzheimer's and Dementia · December 1, 2022 Background: Alzheimer’s disease (AD) has high genetic heritability for both disease risk and age-at-onset (AAO) of AD. However, our understanding of genetics of AAO of AD lags behind AD risk. Here, we utilized two statistical approaches to identify genes m ... Full text Cite

Determinants of Dropout from and Variation in Adherence to an Exercise Intervention: The STRRIDE Randomized Trials.

Journal Article Transl J Am Coll Sports Med · 2022 PURPOSE: This study aimed to characterize the timing and self-reported determinants of exercise dropout among sedentary adults with overweight or obesity. We also sought to explore variations in adherence among individuals who completed a 6- to 8-month str ... Full text Open Access Link to item Cite

Racial and Ethnic Disparities among Thoracic Surgery Patients

Conference ANESTHESIA AND ANALGESIA · 2022 Cite

Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.

Journal Article Genome Med · April 30, 2021 BACKGROUND: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly unde ... Full text Open Access Link to item Cite

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.

Journal Article Eur Heart J · March 1, 2021 AIMS: While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic factors which establish atheros ... Full text Open Access Link to item Cite

Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.

Journal Article Aging (Albany NY) · December 7, 2020 BACKGROUND: Accelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental exposures. METHODS: Using 497 participan ... Full text Open Access Link to item Cite

Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.

Journal Article Transl Psychiatry · October 20, 2020 In prior work, we identified a novel gene-by-stress association of EBF1's common variation (SNP rs4704963) with obesity (i.e., hip, waist) in Whites, which was further strengthened through multiple replications using our synthetic stress measure. We now ex ... Full text Open Access Link to item Cite

Abstract P461: Genome-wide Analysis in Sedentary Adults of Non-completion of a Controlled Exercise Intervention

Conference Circulation · March 3, 2020 A wide range of health benefits of exercise have been documented in clinical lifestyle medicine. However, many individuals fail to complete or maintain an exercise program. We hypothesized that this behavior has biological underpinning ... Full text Cite

Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.

Journal Article SSM Popul Health · December 2019 The present study used harmonized data from eight studies (N = 28,891) to examine the association between socioeconomic status (SES) and resting systolic blood pressure (SBP). The study replicates and extends our prior work on this topic by examining poten ... Full text Open Access Link to item Cite

Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.

Journal Article Front Genet · 2018 The serotonin receptor 5-HTR2C is thought to be involved in the function of multiple brain structures. Consequently, the HTR2C gene has been studied extensively with respect to its association with a variety of phenotypes. One coding variant in the HTR2C g ... Full text Open Access Link to item Cite

Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort.

Journal Article Am Heart J · August 2017 BACKGROUND: The rs6265 (Val66Met) single-nucleotide polymorphism in the BDNF gene has been related to a number of endophenotypes that have in turn been shown to confer risk for atherosclerotic cardiovascular disease (CVD). To date, however, very few studie ... Full text Link to item Cite

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.

Journal Article Psychoneuroendocrinology · May 2017 Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with cortisol responses to stress with gender differences reported, although the findings are not entirely consistent. To evaluate the role of Val66Met genotype and gender o ... Full text Link to item Cite

Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.

Journal Article Genet Epidemiol · September 2015 Chronic psychosocial stress adversely affects health and is associated with the development of disease [Williams, 2008]. Systematic epidemiological and genetic studies are needed to uncover genetic variants that interact with stress to modify metabolic res ... Full text Link to item Cite

Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.

Journal Article Eur J Hum Genet · June 2015 We performed gene-environment interaction genome-wide association analysis (G × E GWAS) to identify SNPs whose effects on metabolic traits are modified by chronic psychosocial stress in the Multi-Ethnic Study of Atherosclerosis (MESA). In Whites, the G × E ... Full text Open Access Link to item Cite

DRD2 SNP RS4586205, CHD METABOLIC RISK FACTORS IN NORMALS AND CLINICAL COURSE IN CHD PATIENTS

Conference INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE · August 1, 2014 Link to item Cite

A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.

Journal Article PLoS One · 2014 Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise caus ... Full text Open Access Link to item Cite

Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.

Journal Article Biol Psychol · April 2013 TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride level ... Full text Link to item Cite

Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms.

Journal Article J Psychiatr Res · February 2013 BACKGROUND: BDNF Val66Met by chronic stress interaction has been studied using childhood stress as a moderator, but has not been widely studied using chronic stress in adulthood. METHODS: Two independent samples were used: Duke-CG (238 Caucasians) and MESA ... Full text Link to item Cite

A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.

Journal Article PLoS One · 2013 Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (rs6318) of the 5HTR2C gene located on the X-chromosome is associated with hypothalamic-pituitary-adrenal axis response to a stress recall task, and with endophenotypes ... Full text Open Access Link to item Cite

Socioeconomic indices as independent correlates of C-reactive protein in the National Longitudinal Study of Adolescent Health.

Journal Article Psychosom Med · 2013 OBJECTIVES: To examine the association between socioeconomic status (SES) and C-reactive protein (CRP) to understand how SES may increase the risk of cardiovascular disease and thus identify targets for prevention measures. METHODS: Path models were used t ... Full text Link to item Cite