Ryan McNabb

Journal Article Sci Adv · May 9, 2025 Adaptive optics scanning light ophthalmoscopy (AOSLO) reveals individual retinal cells and their function, microvasculature, and micropathologies in vivo. As compared to the single-channel offset pinhole and two-channel split-detector nonconfocal AOSLO des ... Full text Link to item Cite

Mobile Robotic Optical Coherence Tomography System for Ophthalmic Imaging in Clinical Environments.

Journal Article Int Symp Med Robot · May 2025 Optical coherence tomography (OCT) is an indispensable imaging modality for the diagnosis and management of many common eye diseases. We previously presented a fixed-base robotic OCT system to enable automated imaging and alleviate the necessity for restri ... Full text Link to item Cite

Sensor-driven digital motion correction of robotically-aligned optical coherence tomography retinal volumes.

Journal Article Biomed Opt Express · April 1, 2025 Optical coherence tomography (OCT) has revolutionized diagnostics in retinal ophthalmology. Traditional OCT requires minimal relative motion between the subject and scanner, which is difficult to achieve with handheld devices and/or non-stabilized subjects ... Full text Link to item Cite

Pupil wobble in point-scanning retinal optical coherence tomography systems.

Journal Article Opt Lett · March 15, 2025 Optical coherence tomography (OCT) systems utilize 2D scanning methods to acquire reflectance-based volumetric images of samples, such as the human retina, with micrometer-scale depth resolution. A common method for performing this scanning at high speeds ... Full text Link to item Cite

Robotics and optical coherence tomography: current works and future perspectives [Invited].

Journal Article Biomed Opt Express · February 1, 2025 Optical coherence tomography (OCT) is an interferometric technique for micron-level imaging in biological and non-biological contexts. As a non-invasive, non-ionizing, and video-rate imaging modality, OCT is widely used in biomedical and clinical applicati ... Full text Link to item Cite

New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.

Journal Article Transl Vis Sci Technol · January 2, 2025 The introduction of optical coherence tomography (OCT) in the 1990s revolutionized diagnostic ophthalmic imaging. Initially, OCT's role was primarily in the adult ambulatory ophthalmic clinics. Subsequent advances in handheld form factors, integration into ... Full text Link to item Cite

Improving Artificial Intelligence-based Microbial Keratitis Screening Tools Constrained by Limited Data Using Synthetic Generation of Slit-Lamp Photos.

Journal Article Ophthalmol Sci · 2025 OBJECTIVE: We developed a novel slit-lamp photography (SLP) generative adversarial network (GAN) model using limited data to supplement and improve the performance of an artificial intelligence (AI)-based microbial keratitis (MK) screening model. DESIGN: C ... Full text Link to item Cite

Distortion-Corrected Posterior Ocular Shape in Myopic Eyes Assessed by Ultrawide OCT Detects Deformations Associated With Vision-Threatening Changes.

Journal Article Invest Ophthalmol Vis Sci · November 4, 2024 PURPOSE: To develop a quantitative tool for assessing the posterior ocular shape using widefield, volumetric optical coherence tomography (OCT) in eyes with myopia. METHODS: This observational, cross-sectional study included 178 eyes from 113 participants. ... Full text Link to item Cite

RobOCTNet: Robotics and Deep Learning for Referable Posterior Segment Pathology Detection in an Emergency Department Population.

Journal Article Transl Vis Sci Technol · March 1, 2024 PURPOSE: To evaluate the diagnostic performance of a robotically aligned optical coherence tomography (RAOCT) system coupled with a deep learning model in detecting referable posterior segment pathology in OCT images of emergency department patients. METHO ... Full text Link to item Cite

NOVEL METHOD FOR VISUALIZING PERIPHERAL RETINAL STRUCTURES WITH MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retin Cases Brief Rep · July 1, 2023 BACKGROUND/PURPOSE: Visualization of peripheral retinal structures with optical coherence tomography (OCT) can be challenging but can offer valuable clinical information. We describe a method for intraoperative OCT of the peripheral retina. METHODS: An inv ... Full text Link to item Cite

Robotic Optical Coherence Tomography Retinal Imaging for Emergency Department Patients: A Pilot Study for Emergency Physicians' Diagnostic Performance.

Journal Article Ann Emerg Med · April 2023 STUDY OBJECTIVE: To evaluate the diagnostic performance of emergency physicians' interpretation of robotically acquired retinal optical coherence tomography images for detecting posterior eye abnormalities in patients seen in the emergency department (ED). ... Full text Link to item Cite

Robotic Optical Coherence Tomography of Human Subjects with Posture-Invariant Head and Eye Alignment in Six Degrees of Freedom.

Conference Int Symp Med Robot · April 2023 Ophthalmic optical coherence tomography (OCT) has achieved remarkable clinical success but remains sequestered in ophthalmology specialty offices. Recently introduced robotic OCT systems seek to expand patient access but fall short of their full potential ... Full text Link to item Cite

Contactless, autonomous robotic alignment of optical coherence tomography for in vivo evaluation of diseased retinas.

Preprint · January 9, 2023 Full text Link to item Cite

Dual modality handheld adaptive optics optical coherence tomography probe for in vivo 3-D photoreceptor imaging

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2023 Adaptive optics optical coherence tomography (AO-OCT) has allowed for the reliable 3-D imaging of individual retinal cells. The current AO-OCT systems are limited to tabletop implementation due to their size and complexity. This work describes the design a ... Full text Cite

Adaptive point-scan imaging beyond the frame rate-resolution limit with scene-reactive scan trajectories.

Journal Article Optica · November 20, 2022 Point-scanned imaging modalities, such as optical coherence tomography (OCT), are subject to frame rate limits governed by image resolution, sampling rate, and scanner dynamics. For scenes with dynamic features on static backgrounds, adaptive scanning esca ... Full text Link to item Cite

Optical coherence tomography refraction and optical path length correction for image-guided corneal surgery.

Journal Article Biomed Opt Express · September 1, 2022 Optical coherence tomography (OCT) may be useful for guidance of ocular microsurgeries such as deep anterior lamellar keratoplasty (DALK), a form of corneal transplantation that requires delicate insertion of a needle into the stroma to approximately 90% o ... Full text Link to item Cite

Computational 3D microscopy with optical coherence refraction tomography.

Journal Article Optica · June 20, 2022 Optical coherence tomography (OCT) has seen widespread success as an in vivo clinical diagnostic 3D imaging modality, impacting areas including ophthalmology, cardiology, and gastroenterology. Despite its many advantages, such as high sensitivity, speed, a ... Full text Link to item Cite

Practice Patterns of Fundoscopic Examination for Diabetic Retinopathy Screening in Primary Care.

Journal Article JAMA Netw Open · June 1, 2022 IMPORTANCE: Primary care professionals (PCPs) have a central role in screening for diabetic retinopathy (DR), especially in settings where access to specialty eye care is limited. Data on current DR screening practice patterns in primary care are needed to ... Full text Link to item Cite

Assessment of deep learning-based triage for robotically acquired retinal optical coherence tomography (OCT) images in an emergency department population

Conference Investigative Ophthalmology and Visual Science · June 1, 2022 Link to item Cite

Autonomous Robotically Aligned OCT Enables Remote, Telehealth Retinal Imaging and Angiography

Conference Investigative Ophthalmology and Visual Science · June 1, 2022 Link to item Cite

Data from: Computational 3D microscopy with optical coherence refraction tomography

Dataset · April 12, 2022 This repository contains multi-angle volumetric OCT datasets for 3D OCRT reconstruction of four biological samples (zebrafish larva, fruit fly, mouse esophagus, and mouse trachea). The OCT volumes were captured using a custom spectral domain OCT system wit ... Full text Cite

Nonlinear distortion correction for posterior eye segment optical coherence tomography with application to tree shrews.

Journal Article Biomed Opt Express · February 1, 2022 We propose an empirical distortion correction approach for optical coherence tomography (OCT) devices that use a fan-scanning pattern to image the posterior eye segment. Two types of reference markers were used to empirically estimate the distortion correc ... Full text Link to item Cite

Robotically-Aligned Optical Coherence Tomography with Gaze Tracking for Live Image Montaging of the Retina

Conference Proceedings IEEE International Conference on Robotics and Automation · January 1, 2022 Optical coherence tomography (OCT) has revolutionized diagnostics in ophthalmology. However, it requires pa-tient cooperation to fixate on multiple targets and stabilize their head utilizing both chin and forehead rests. Patient cooperation is particularly ... Full text Cite

In vivo recumbent photoreceptor imaging using the first handheld adaptive optics optical coherence tomography probe

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

Head orientation-independent optical coherence tomography with a robotically-aligned scanner

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

Robotically Aligned OCT Enables Synthetically Increased Field-of-View on Automatically Acquired Retinal Images

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

Automated visualization of Henle's fiber layer and outer nuclear layer in retinal volumes using robotically-aligned optical coherence tomography

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

High-speed multiview imaging approaching 4pi steradians using conic section mirrors: theoretical and practical considerations.

Journal Article J Opt Soc Am A Opt Image Sci Vis · December 2021 Illuminating or imaging samples from a broad angular range is essential in a wide variety of computational 3D imaging and resolution-enhancement techniques, such as optical projection tomography, optical diffraction tomography, synthetic aperture microscop ... Full text Link to item Cite

High-speed multiview imaging approaching 4pi steradians using conic section mirrors: theoretical and practical considerations

Journal Article Journal of the Optical Society of America A · December 1, 2021 Illuminating or imaging samples from a broad angular range is essential in a wide variety of computational 3D imaging and resolution-enhancement techniques, such as optical projection tomography, optical diffraction tomography, synthetic aperture m ... Full text Cite

Robotically aligned optical coherence tomography with 5 degree of freedom eye tracking for subject motion and gaze compensation.

Journal Article Biomed Opt Express · December 1, 2021 Optical coherence tomography (OCT) has revolutionized diagnostics in ophthalmology. However, OCT requires a trained operator and patient cooperation to carefully align a scanner with the subject's eye and orient it in such a way that it images a desired re ... Full text Link to item Cite

Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT).

Journal Article Biomed Opt Express · September 1, 2021 Ocular deformation may be associated with biomechanical alterations in the structures of the eye, especially the cornea and sclera in conditions such as keratoconus, congenital glaucoma, and pathological myopia. Here, we propose a method to estimate ocular ... Full text Link to item Cite

Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner.

Journal Article Nat Biomed Eng · July 2021 Clinical systems for optical coherence tomography (OCT) are used routinely to diagnose and monitor patients with a range of ocular diseases. They are large tabletop instruments operated by trained staff, and require mechanical stabilization of the head of ... Full text Link to item Cite

QUANTITATIVE TOPOGRAPHIC CURVATURE MAPS OF THE POSTERIOR EYE UTILIZING OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retina · April 1, 2021 PURPOSE: Deformations of the retina such as staphylomas in myopia or scleral flattening in high intracranial pressure can be challenging to quantify with en face imaging. We describe an optical coherence tomography-based method for the generation of quanti ... Full text Open Access Link to item Cite

In vivo quantitative analysis of anterior chamber white blood cell mixture composition using spectroscopic optical coherence tomography.

Journal Article Biomed Opt Express · April 1, 2021 Anterior uveitis is the most common form of intraocular inflammation, and one of its main signs is the presence of white blood cells (WBCs) in the anterior chamber (AC). Clinically, the true composition of cells can currently only be obtained using AC para ... Full text Link to item Cite